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[PMID]:28329478
[Au] Autor:António AM; Alves J; Barreiros H; Bártolo E
[Ad] Endereço:Dermatovenereology Department, Hospital Garcia de Orta, Almada, Portugal. anamartaantonio@gmail.com.
[Ti] Título:Eruptive collagenoma in a child.
[So] Source:Dermatol Online J;23(1), 2017 Jan 15.
[Is] ISSN:1087-2108
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Eruptive collagenoma is a rare entity, with unknownetiology, considered to be a type of connective tissuenevus composed of collagen. It is usually reported inyoung adults occurring predominantly on the trunkand extremities. Systemic findings and family historyof a similar condition are not typically associated andthe prognosis is excellent. There are few pediatric casesreported in literature. Herein we report an uncommoncase of eruptive collagenoma in a 12-year-old childand present a brief review of the literature.
[Mh] Termos MeSH primário: Doenças do Colágeno/diagnóstico
Neoplasias Primárias Múltiplas/diagnóstico
Nevo/diagnóstico
Neoplasias Cutâneas/diagnóstico
[Mh] Termos MeSH secundário: Criança
Doenças do Colágeno/patologia
Seres Humanos
Masculino
Neoplasias Primárias Múltiplas/patologia
Nevo/patologia
Neoplasias Cutâneas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE


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[PMID]:28320435
[Au] Autor:Gao P; Jing L; Huang H; Zhang C; Hao J
[Ad] Endereço:Department of Pathology, Yantai Affiliated Hospital of Binzhou Medical University, No. 717, Jinbu Street, Yantai, Shandong Province, 264100, China.
[Ti] Título:Case report: a case of eruptive collagenoma occurring in esophagus and intestine.
[So] Source:Diagn Pathol;12(1):30, 2017 Mar 20.
[Is] ISSN:1746-1596
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Eruptive collagenoma is a rare disease. All of the previously reported cases were located on the skin. Here we report such a case occurring in esophagus and intestine. CASE PRESENTATION: Our patient is a Chinese woman. Two years ago, hundreds of small nodules were identified in her esophagus and intestine. The lesions were characterized by thickened hyalinized collagen fibers and haphazard neoplastic stellate cells. The tumor cells showed generally positive for vimentin and negative for h-CALD, CD34, desmin, CD163, AE1/AE3, CK7 and CK20. The nodules were blue with Masson Trichrome stain. The clinicopathological, immunohistochemical and histochemical features of the tumor were consistent with eruptive collagenoma. The patient was not given specific treatment after diagnosis, and a routine examination indicated that there was no progress for 2 years. CONCLUSION: Hitherto, this is the first case of eruptive collagenoma to have been reported occurring in esophagus and intestine.
[Mh] Termos MeSH primário: Doenças do Colágeno/patologia
Doenças do Colo/patologia
Doenças do Esôfago/patologia
Hamartoma/patologia
Doenças do Íleo/patologia
[Mh] Termos MeSH secundário: Biomarcadores/análise
Biópsia
Doenças do Colágeno/metabolismo
Doenças do Colo/metabolismo
Endoscopia Gastrointestinal
Doenças do Esôfago/metabolismo
Feminino
Hamartoma/química
Seres Humanos
Doenças do Íleo/metabolismo
Imuno-Histoquímica
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1186/s13000-017-0617-4


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[PMID]:28247107
[Au] Autor:Maeda H; Kanzaki M; Sakamoto K; Isaka T; Oyama K; Murasugi M; Onuki T
[Ad] Endereço:Department of Surgery I, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
[Ti] Título:Effect of collagen vascular disease-associated interstitial lung disease on the outcomes of lung cancer surgery.
[So] Source:Surg Today;47(9):1072-1079, 2017 Sep.
[Is] ISSN:1436-2813
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:PURPOSE: This study compared the effect of collagen vascular disease-associated interstitial lung disease (CVD-ILD) with that of idiopathic interstitial pneumonias (IIPs) on the outcomes of lung cancer surgery. METHODS: This study retrospectively reviewed the medical records of patients who underwent surgery for non-small cell lung cancer (NSCLC) and compared the data of 16 patients with CVD-ILD with those of 70 patients with IIPs. The patterns of interstitial lung disease (ILD) on chest computed tomography were classified into usual interstitial pneumonia (UIP) and non-specific interstitial pneumonia (NSIP) patterns. RESULTS: The numbers of UIP and NSIP patterns were 10 (62.5%) and 6 (37.5%) patients in CVD-ILD group, and 62 (88.6%) and 8 (11.4%) patients in IIPs group, respectively. A postoperative acute exacerbation (AE) appeared in 1 patient (6.3%) in the CVD-ILD group and 6 patients (8.6%) in the IIPs group. No significant differences in the incidence of postoperative AE and mortalities were observed between the two groups. The five-year overall survival rates of the CVD-ILD and IIPs groups were 37.5 and 49.2%, respectively. CONCLUSIONS: Surgery for NSCLC in CVD-ILD patients appear to cause no increase in postoperative AE and mortality in comparison to that seen in IIPs patients. Similar to IIPs, CVD-ILD might therefore affect the prognosis of resected NSCLC.
[Mh] Termos MeSH primário: Carcinoma Pulmonar de Células não Pequenas/complicações
Carcinoma Pulmonar de Células não Pequenas/cirurgia
Doenças do Colágeno/complicações
Doenças Pulmonares Intersticiais/complicações
Neoplasias Pulmonares/cirurgia
Doenças Vasculares/complicações
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Carcinoma Pulmonar de Células não Pequenas/mortalidade
Doenças do Colágeno/diagnóstico por imagem
Feminino
Seres Humanos
Doenças Pulmonares Intersticiais/diagnóstico por imagem
Neoplasias Pulmonares/complicações
Neoplasias Pulmonares/mortalidade
Masculino
Meia-Idade
Estudos Retrospectivos
Taxa de Sobrevida
Tomografia Computadorizada por Raios X
Resultado do Tratamento
Doenças Vasculares/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE
[do] DOI:10.1007/s00595-017-1476-z


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[PMID]:28109507
[Au] Autor:Husain Q; Cho J; Neugarten J; Modi VK
[Ad] Endereço:Department of Otolaryngology - Head & Neck Surgery, Weill Cornell Medical College, New York, NY, USA.
[Ti] Título:Surgery of the head and neck in patient with Kniest dysplasia: Is wound healing an issue?
[So] Source:Int J Pediatr Otorhinolaryngol;93:97-99, 2017 Feb.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Kniest dysplasia is a type II collagen disorder that arises from a genetic mutation of the COL2A1 gene that results in short stature, midface anomalies, tracheomalacia, and hearing loss. Disruption of the normal collagen pathway can lead to many changes given its critical role in the body, and can cause complications with respect to wound healing. We present a case in which a patient with Kniest dysplasia successfully underwent multiple procedures in the head and neck region including cochlear implantation, mandibular distraction, palatoplasty, and laryngotracheal reconstruction. All procedures did not have any associated complications with respect to wound healing, indicating that surgery in this population can take place as indicated and surgery should not be contraindicated or delayed.
[Mh] Termos MeSH primário: Fissura Palatina/cirurgia
Implante Coclear
Doenças do Colágeno/cirurgia
Nanismo/cirurgia
Face/anormalidades
Doença da Membrana Hialina/cirurgia
Avanço Mandibular
Procedimentos Cirúrgicos Ortognáticos
Osteocondrodisplasias/cirurgia
Procedimentos Cirúrgicos Otorrinolaringológicos
Cicatrização
[Mh] Termos MeSH secundário: Face/cirurgia
Seres Humanos
Lactente
Masculino
Avanço Mandibular/métodos
Osteogênese por Distração
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170123
[St] Status:MEDLINE


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[PMID]:28329555
[Au] Autor:Rosenstein R; Martires K; Christman M; Terushkin V; Meehan SA; Seminara N; Golden BD; Franks AG
[Ad] Endereço:Ronald O. Perelman Department of Dermatology, NYU School of Medicine, NYU Langone Medical Center.
[Ti] Título:Dermatomyositis, clinically presenting with cutaneous ulcers, with histopathologic evidence of perforating collagenosis.
[So] Source:Dermatol Online J;22(12), 2016 Dec 15.
[Is] ISSN:1087-2108
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dermatomyositis is a systemic, autoimmune diseasewith a variety of clinical features that often includemyositis and characteristic cutaneous findings. Asubset of patients with dermatomyositis developcutaneous ulcers, often in the setting of vasculitis orvasculopathy. We present a case of dermatomyositiswith cutaneous ulcers that show perforatingcollagenosis on histopathologic examination.Acquired reactive perforating collagenosistypically occurs in the setting of diabetes mellitus,chronic renal failure, and other pruritic conditions,and this case represents a rare association withdermatomyositis, which may ultimately be helpful inelucidating the pathophysiology of this perforatingdisorder.
[Mh] Termos MeSH primário: Doenças do Colágeno/diagnóstico
Dermatomiosite/diagnóstico
Dermatoses Faciais/diagnóstico
Dermatoses da Mão/diagnóstico
Dermatoses do Couro Cabeludo/diagnóstico
Úlcera Cutânea/diagnóstico
[Mh] Termos MeSH secundário: Doenças do Colágeno/etiologia
Doenças do Colágeno/patologia
Dermatomiosite/complicações
Dermatomiosite/patologia
Extremidades
Dermatoses Faciais/etiologia
Dermatoses Faciais/patologia
Feminino
Dermatoses da Mão/etiologia
Dermatoses da Mão/patologia
Seres Humanos
Meia-Idade
Dermatoses do Couro Cabeludo/etiologia
Dermatoses do Couro Cabeludo/patologia
Úlcera Cutânea/etiologia
Úlcera Cutânea/patologia
Tronco
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE


  6 / 4744 MEDLINE  
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[PMID]:28300880
[Au] Autor:Fernandes KA; Lima LA; Guedes JC; Lima RB; D'Acri AM; Martins CJ
[Ad] Endereço:Universidade Federal do Estado do Rio de Janeiro (UNIRIO) - Rio de Janeiro (RJ), Brazil.
[Ti] Título:Acquired perforating dermatosis in a patient with chronic renal failure.
[So] Source:An Bras Dermatol;91(5 suppl 1):10-13, 2016 Sep-Oct.
[Is] ISSN:1806-4841
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Perforating dermatoses are a group of skin diseases characterized by transepidermal elimination of dermal material. The disease is divided into two groups: the primary group and the secondary group. The classical or primary perforating dermatoses are subdivided into four types according to the eliminated dermal materials: Kyrle disease, perforating reactive collagenosis, elastosis perforans serpiginosa, and perforating folliculitis. The secondary form is known as acquired perforating dermatosis. The term was proposed in 1989 by Rapini to designate the perforating dermatoses affecting adult patients with systemic disease, regardless of the dermal materials eliminated. This report describes a case of the disease with elimination of collagen and elastic fibers in a patient with chronic renal failure.
[Mh] Termos MeSH primário: Doenças do Colágeno/patologia
Epiderme/patologia
Falência Renal Crônica/complicações
Dermatopatias/etiologia
Dermatopatias/patologia
[Mh] Termos MeSH secundário: Colágeno
Tecido Elástico/patologia
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
9007-34-5 (Collagen)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170706
[Lr] Data última revisão:
170706
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE


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[PMID]:27981816
[Au] Autor:Mencarini J; Spinicci M; Bartalesi F
[Ad] Endereço:Infectious Diseases Unit, University of Florence. jessicamencarini@gmail.com.
[Ti] Título:Risk of cytomegalovirus reactivation in patients with immune-mediated inflammatory diseases undergoing biologic treatment: a real matter?
[So] Source:Reumatismo;68(3):144-147, 2016 Dec 16.
[Is] ISSN:0048-7449
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:The use of biological agents has grown exponentially in immune-mediated inflammatory diseases (IMID), often achieving a good control of disease progression and improving patients' quality of life. However, their use resulted in an increased risk of adverse events, including reactivation of chronic/latent infectious diseases. As for the risk of Cytomegalovirus (CMV) reactivation, very few data are available. We reviewed the literature reporting cases of CMV infection in IMID patients during biological therapy. Although the risk of CMV reactivation cannot be excluded, we concluded that there is no evidence to warrant CMV screening before starting a biological agent.
[Mh] Termos MeSH primário: Produtos Biológicos/efeitos adversos
Doenças do Colágeno/virologia
Infecções por Citomegalovirus/diagnóstico
Citomegalovirus
Imunossupressores/efeitos adversos
[Mh] Termos MeSH secundário: Doenças do Colágeno/tratamento farmacológico
Doenças do Colágeno/imunologia
Citomegalovirus/imunologia
Infecções por Citomegalovirus/imunologia
Infecções por Citomegalovirus/virologia
Seres Humanos
Prognóstico
Ativação Viral/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biological Products); 0 (Immunosuppressive Agents)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE
[do] DOI:10.4081/reumatismo.2016.897


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[PMID]:27670281
[Au] Autor:Iizuka Y; Iizuka H; Kaneko T; Mieda T; Takechi R; Suzuki H; Sorimachi Y; Suto T; Tachibana M; Yoneyama T; Omodaka T; Hashimoto S; Hamano N; Sakane H; Shimoyama D; Kohama I; Ohshima A; Nozaki T; Kamiyama M; Moteki T; Ohshima A; Takamine S; Honda A; Ueno A; Tajika T; Okamura K; Warita T; Yonemoto Y; Shitara H; Ohsawa T; Takagishi K
[Ad] Endereço:Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, 3-39-22, Showamachi, Maebashi, Gunma 371-8511, Japan. Electronic address: yoiizuka@gunma-u.ac.jp.
[Ti] Título:Bone turnover markers and the factors associated with atypical femur fractures among Japanese patients.
[So] Source:Injury;47(11):2484-2489, 2016 Nov.
[Is] ISSN:1879-0267
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Many previous reports have indicated that atypical femur fractures (AFFs) are associated with the administration of bisphosphonates (BPs). A number of risk factors and hypotheses regarding the pathogenesis of AFFs have been reported to date. The purpose of the present study was to identify the factors associated with AFFs in Japanese individuals and to elucidate the association between bone metabolism and AFFs by evaluating bone turnover markers (BTMs). We prospectively reviewed all patients with femur fractures and identified the patients with AFFs and typical femur fractures (TFFs). We collected the demographic and clinical data that were relevant to the present study, namely age, gender, affected side, affected site, concomitant medical history, and comorbid conditions, and measured the levels of BTMs within 24h after trauma. Welch's test and Fisher's exact probability test were used for the statistical analyses. A total of 338 patients, including 10 patients with AFFs and 328 patients with TFFs, were analyzed under the inclusion criteria. The use of BPs (p<0.001) and collagen disease and chronic granulomatous disease (CD/CGD) (p=0.025) were more frequently observed in patients with AFFs than in patients with TFFs, while the levels of BTMs, including N-terminal propeptides of type 1 procollagen (P1NP), isoform 5b of tartrate-resistant acid phosphatase (TRACP-5b) and undercarboxylated osteocalcin (ucOC) were significantly lower in patients with AFFs than in patients with TFFs. Furthermore, the level of TRACP-5b was found to be significantly lower in patients with atypical subtrochanteric fractures than in atypical diaphyseal fractures (p=0.025). Moreover, the levels of P1NP (p=0.016) and TRACP-5b (p=0.015) were found to be significantly lower in patients with AFFs than in patients with TFFs in a subgroup analysis of BPs users. The use of BPs was considered to be a factor associated with AFFs. Our comparison of the BTMs in patients with AFFs and TFFs indicated that the severe suppression of bone turnover was associated with the pathogenesis of AFFs. The extent of the influence of suppressed turnover on the pathogenesis of AFFs may differ depending on the fracture site.
[Mh] Termos MeSH primário: Conservadores da Densidade Óssea/efeitos adversos
Remodelação Óssea
Doenças do Colágeno/patologia
Difosfonatos/efeitos adversos
Fraturas do Fêmur/patologia
Consolidação da Fratura/fisiologia
Doença Granulomatosa Crônica/patologia
Osteoporose/patologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Grupo com Ancestrais do Continente Asiático
Biomarcadores/sangue
Remodelação Óssea/efeitos dos fármacos
Doenças do Colágeno/sangue
Doenças do Colágeno/epidemiologia
Comorbidade
Estudos Transversais
Feminino
Fraturas do Fêmur/sangue
Fraturas do Fêmur/epidemiologia
Doença Granulomatosa Crônica/sangue
Doença Granulomatosa Crônica/epidemiologia
Seres Humanos
Japão/epidemiologia
Masculino
Meia-Idade
Osteoporose/sangue
Osteoporose/tratamento farmacológico
Osteoporose/epidemiologia
Fragmentos de Peptídeos
Pró-Colágeno
Estudos Prospectivos
Fatores de Risco
Fosfatase Ácida Resistente a Tartarato
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Bone Density Conservation Agents); 0 (Diphosphonates); 0 (Peptide Fragments); 0 (Procollagen); 0 (procollagen Type I N-terminal peptide); EC 3.1.3.2 (ACP5 protein, human); EC 3.1.3.2 (Tartrate-Resistant Acid Phosphatase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160928
[St] Status:MEDLINE


  9 / 4744 MEDLINE  
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[PMID]:27659711
[Au] Autor:Vogel MN; Kreuter M; Kauczor HU; Heußel CP
[Ad] Endereço:Abteilung für Diagnostische und Interventionelle Radiologie mit Nuklearmedizin, Thoraxklinik, Universitätsklinikum Heidelberg, Röntgenstr. 1, 69126, Heidelberg, Deutschland. monika.vogel@med.uni-heidelberg.de.
[Ti] Título:[Pulmonary manifestations in collagen vascular diseases].
[Ti] Título:Pulmonale Manifestationen bei Kollagenosen..
[So] Source:Radiologe;56(10):910-916, 2016 Oct.
[Is] ISSN:1432-2102
[Cp] País de publicação:Germany
[La] Idioma:ger
[Ab] Resumo:CLINICAL/METHODICAL ISSUE: Pulmonary complications are frequent in patients with collagen vascular diseases (CVD). Frequent causes are a direct manifestation of the underlying disease, side effects of specific medications and lung infections. STANDARD RADIOLOGICAL METHODS: The standard radiological procedure for the work-up of pulmonary pathologies in patients with CVD is multidetector computed tomography (MDCT) with thin-slice high-resolution reconstruction. PERFORMANCE: The accuracy of thin-slice CT for the identification of particular disease patterns is very high. The pattern of usual interstitial pneumonia (UIP) representing the direct pulmonary manifestation of rheumatoid arthritis (RA) can be identified with a sensitivity of 45 % and a specificity of 96 %. ACHIEVEMENTS: Both direct pulmonary manifestations, drug-induced toxicity and certain infections can have a similar appearance in thin-slice MDCT in various forms of CVD. Knowledge of the patterns and causes contributes to the diagnostic certainty. PRACTICAL RECOMMENDATIONS: At first diagnosis of a CVD and associated pulmonary symptoms thin-slice MDCT is recommended. Clinical, lung function and imaging follow-up examinations should be performed every 6-12 months depending on the results of the MDCT. In every case the individual CT morphological patterns of pulmonary involvement must be identified. The combination of information on the anamnesis, clinical and imaging results is a prerequisite for an appropriate disease management.
[Mh] Termos MeSH primário: Doenças do Colágeno/diagnóstico por imagem
Doenças Pulmonares Intersticiais/diagnóstico por imagem
Tomografia Computadorizada Multidetectores/métodos
Doenças Vasculares/diagnóstico por imagem
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Seres Humanos
Radiografia Torácica/métodos
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160924
[St] Status:MEDLINE


  10 / 4744 MEDLINE  
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[PMID]:27472707
[Au] Autor:Fei C; Wang Y; Gong Y; Xu H; Yu Q; Shi Y
[Ad] Endereço:Department of Dermatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
[Ti] Título:Acquired reactive perforating collagenosis: A report of a typical case.
[So] Source:Medicine (Baltimore);95(30):e4305, 2016 Jul.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Reactive perforating collagenosis (RPC) is a rare form of transepithelial elimination, in which altered collagen is extruded through the epidermis. There are 2 types of RPC, acquired RPC (ARPC) and inherited RPC, while the latter is extremely rare. Here we report on 1 case of ARPC. METHODS: A 73-year-old female was presented with strongly itchy papules over her back and lower limbs for 3 months. She denied the history of oozing or vesiculation. A cutaneous examination showed diffusely distributed multiple well-defined keratotic papules, 4 to 10 mm in diameter, on the bilateral lower limbs and back as well as a few papules on her chest and forearm. Scratching scars were over the resolved lesions while Koebner phenomenon was negative. The patient had a history of type 2 diabetes for 15 years. Laboratory examinations showed elevated blood glucose level. Skin lesion biopsy showed a well-circumscribed area of necrosis filled with a keratotic plug. Parakeratotic cells and lymphocytic infiltration could be seen in the necrosed area. In dermis, sparse fiber bundles were seen perforating the epidermis. These degenerated fiber bundles were notarized as collagen fiber by elastic fiber stain, suggesting a diagnosis of RPC. RESULTS: Then a diagnosis of ARPC was made according to the onset age and the history of diabetes mellitus. She was treated with topical application of corticosteroids twice a day and oral antihistamine once a day along with compound glycyrrhizin tablets 3 times a day. And the blood glucose was controlled in a satisfying range. Two months later, a significant improvement was seen in this patient. CONCLUSION: Since there is no efficient therapy to RPC, moreover, ARPC is considered to be associated with some systemic diseases, the management of the coexisting disease is quite crucial. The patient in this case received a substantial improvement due to the control of blood glucose and application of compound glycyrrhizin tablets.
[Mh] Termos MeSH primário: Doenças do Colágeno/diagnóstico
Dermatopatias Papuloescamosas/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Anti-Inflamatórios/uso terapêutico
Doenças do Colágeno/tratamento farmacológico
Diagnóstico Diferencial
Quimioterapia Combinada
Feminino
Ácido Glicirrízico/uso terapêutico
Antagonistas dos Receptores Histamínicos/uso terapêutico
Seres Humanos
Dermatopatias Papuloescamosas/tratamento farmacológico
Esteroides/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Histamine Antagonists); 0 (Steroids); 6FO62043WK (Glycyrrhizic Acid)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160730
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000004305



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