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Pesquisa : C17.300.710 [Categoria DeCS]
Referências encontradas : 1437 [refinar]
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[PMID]:29288667
[Au] Autor:Oishi K; Ohyama S; Higo-Yamamoto S
[Ad] Endereço:Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan; Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda, Chiba, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan. Electronic address: k-ooishi@aist.go.jp.
[Ti] Título:Chronic sleep disorder induced by psychophysiological stress induces glucose intolerance without adipose inflammation in mice.
[So] Source:Biochem Biophys Res Commun;495(4):2616-2621, 2018 01 22.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sleep disturbances are associated with various metabolic diseases such as hypertension and diabetes. We had previously established a mouse model of a psychophysiological stress-induced chronic sleep disorder (CSD) characterized by disrupted circadian rhythms of wheel-running activity, core body temperature, and sleep-wake cycles. To evaluate the underlying mechanisms of metabolic disorders induced by CSD, we created mice with CSD for six weeks and fed them with a high-fat diet. Glucose intolerance with hyperglycemia resulted, although plasma insulin levels and body weight increases were identical between control and CSD mice. Gluconeogenesis and glycolysis were enhanced and suppressed, respectively, in the livers of CSD mice, because the mRNA expression of Pck1 was significantly increased, whereas that of Gck and Pklr were significantly decreased in the CSD mice. Adipose inflammation induced by the high-fat diet seemed suppressed by the CSD, because the mRNA expression levels of Adgre1, Ccl2, and Tnf were significantly downregulated in the adipose tissues of CSD mice. These findings suggest that CSD impair glucose tolerance by inducing gluconeogenesis and suppressing glycolysis. Hyperphasia with hypoleptinemia, hypercorticosteronemia, and increased plasma free fatty acids might be involved in the impaired glucose metabolism under a CSD. Further studies are needed to elucidate the endocrine and molecular mechanisms underlying the associations between sleep disorders and impaired glucose homeostasis that consequently causes diabetes.
[Mh] Termos MeSH primário: Intolerância à Glucose/etiologia
Intolerância à Glucose/fisiopatologia
Transtornos do Sono-Vigília/etiologia
Transtornos do Sono-Vigília/fisiopatologia
Estresse Psicológico/complicações
Estresse Psicológico/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Doença Crônica
Citocinas/metabolismo
Masculino
Camundongos
Paniculite/etiologia
Paniculite/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cytokines)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171231
[St] Status:MEDLINE


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[PMID]:29197574
[Au] Autor:Li C; Li S; Zhang F; Wu M; Liang H; Song J; Lee C; Chen H
[Ad] Endereço:Department of Cardiology, Peking University People's Hospital, Beijing, 100044, China; Beijing Key Laboratory of Early Prediction and Intervention of Acute Myocardial Infarction, Peking University People's Hospital, Beijing, 100044, China; Center for Cardiovascular Translational Research, Peking Uni
[Ti] Título:Endothelial microparticles-mediated transfer of microRNA-19b promotes atherosclerosis via activating perivascular adipose tissue inflammation in apoE mice.
[So] Source:Biochem Biophys Res Commun;495(2):1922-1929, 2018 01 08.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Microparticles(MPs) are the major carriers of circulating microRNAs. Our previous study has shown that microRNA (miR)-19b in endothelial cell-derived microparticles (EMPs) is significantly increased in patients with unstable angina. However, little is known about the relationship between miR-19b in EMPs and the progression of atherosclerosis. The aim of the present study was to define the role and potential mechanism of miR-19b incorporated in EMPs in the development of atherosclerosis. Western-diet-fed apoE mice were injected with phosphate buffered solution(PBS), EMP carrying microRNA control(EMP ) or miR-19b mimic (EMP ) intravenously. Systemic treatment with EMP significantly accelerated carotid artery atherosclerosis progression by increasing lipid, macrophages and smooth muscle cells and decreasing collagen content in atherosclerotic plaque. Fluorescence-labelled EMP injection proved that miR-19b could be transported into perivascular adipose tissue(PVAT) by EMPs. EMP treatment also promoted inflammatory cytokines secretion and macrophages infiltration in PVAT. In further experiment, apoE mice were divided into 3 groups: EMP PVAT(+), EMP PVAT(+) and EMP PVAT(-), based on removing or keeping pericarotid adipose tissue and injected with EMP or EMP . Loss of PVAT attenuated EMP -mediated effects on increasing carotid atherosclerosis formation and inflammatory cytokines level in plaque. EMP inhibited suppressor of cytokine signaling 3 (SOCS3) expression in PVAT. Our findings demonstrate that miR-19b in EMPs exaggerates atherosclerosis progression by augmenting PVAT-specific inflammation proceeded by downregulating SOCS3 expression.
[Mh] Termos MeSH primário: Tecido Adiposo/imunologia
Aterosclerose/imunologia
Micropartículas Derivadas de Células/imunologia
Endotélio Vascular/imunologia
MicroRNAs/imunologia
Paniculite/imunologia
[Mh] Termos MeSH secundário: Animais
Apolipoproteínas E/genética
Masculino
Camundongos
Camundongos Knockout
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Apolipoproteins E); 0 (MIRN19 microRNA, mouse); 0 (MicroRNAs)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171204
[St] Status:MEDLINE


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[PMID]:29072952
[Au] Autor:Hathuc VM; Hristov AC; Smith LB
[Ad] Endereço:From the Sections of Hematopathology (Drs Hathuc and Smith) and Dermatopathology (Dr Hristov) in the Department of Pathology, University of Michigan Medical Center, Ann Arbor.
[Ti] Título:Primary Cutaneous Acral CD8 T-Cell Lymphoma.
[So] Source:Arch Pathol Lab Med;141(11):1469-1475, 2017 Nov.
[Is] ISSN:1543-2165
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Primary cutaneous acral CD8 T-cell lymphoma is a new provisional entity in the 2016 revision of the World Health Organization classification of lymphoid neoplasms. This is a challenging diagnosis because of its rarity, as well as its morphologic and immunophenotypic overlap with other CD8 cytotoxic lymphoid proliferations. Appropriate classification of this entity is crucial because of its indolent clinical behavior compared with other CD8 T-cell lymphomas. Knowledge of the clinical setting, sites of involvement, and morphologic features can aid in correct diagnosis. Here, we review the clinical and pathologic features of primary cutaneous acral CD8 T-cell lymphoma with an emphasis on the differential diagnosis among other C8 T-cell lymphomas.
[Mh] Termos MeSH primário: Linfócitos T CD8-Positivos/patologia
Linfoma Cutâneo de Células T/diagnóstico
[Mh] Termos MeSH secundário: Biomarcadores Tumorais/metabolismo
Linfócitos T CD8-Positivos/metabolismo
Diagnóstico Diferencial
Extremidades
Seres Humanos
Imuno-Histoquímica/tendências
Imunofenotipagem/tendências
Linfoma de Células T/diagnóstico
Linfoma de Células T/metabolismo
Linfoma de Células T/patologia
Linfoma Cutâneo de Células T/metabolismo
Linfoma Cutâneo de Células T/patologia
Linfoma Cutâneo de Células T/terapia
Paniculite/diagnóstico
Paniculite/metabolismo
Paniculite/patologia
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171027
[St] Status:MEDLINE
[do] DOI:10.5858/arpa.2017-0230-RA


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[PMID]:28756227
[Au] Autor:Cai J; Li B; Liu K; Feng J; Gao K; Lu F
[Ad] Endereço:Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guang Zhou, Guang Dong, PR China.
[Ti] Título:Low-dose G-CSF improves fat graft retention by mobilizing endogenous stem cells and inducing angiogenesis, whereas high-dose G-CSF inhibits adipogenesis with prolonged inflammation and severe fibrosis.
[So] Source:Biochem Biophys Res Commun;491(3):662-667, 2017 Sep 23.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hematopoietic stem cells (HSCs) promote fat graft survival by modulating its revascularization. The authors hypothesize that mobilization of HSCs by G-CSF will improve fat graft survival. Hence, we evaluated the effect of different doses of G-CSF on fat grafting. METHODS: Male 8-week-old C57 mice received high-dose G-CSF (100 µg/kg), low-dose G-CSF (10 µg/kg), and PBS (control) intraperitoneally for 7 consecutive days right after autologous fat grafting. Grafted fat was harvested at 1, 4, and 12 weeks for examination. RESULTS: The low-dose G-CSF, high-dose G-CSF, and control groups had retention rates of 73.6% ± 3.1%, 51.6% ± 4.4%, and 44.5% ± 4.0%, respectively, at 12 weeks (low-dose G-CSF versus control and low-dose G-CSF versus high-dose G-CSF, both p < 0.05; no significant difference between high-dose G-CSF and control group). Both doses of G-CSF successfully mobilized HSCs into circulation and upregulated the level of blood-derived stem cells in fat grafts, contributing to improved angiogenesis. However, high-dose G-CSF caused a prolonged macrophage infiltration and elevated level of inflammation (IL-6 and TNF-α), which led to severe fibrosis and impaired adipogenesis (downregulated expression of PPAR-γ and CEBP-α). CONCLUSIONS: Low-dose G-CSF treatment successfully improved fat graft survival by mobilizing HSCs and inducing angiogenesis. However, high-dose G-CSF prolonged inflammation and caused severe fibrosis, leading to impaired adipogenesis and poor fat graft survival.
[Mh] Termos MeSH primário: Tecido Adiposo/imunologia
Tecido Adiposo/transplante
Sobrevivência de Enxerto/efeitos dos fármacos
Fator Estimulador de Colônias de Granulócitos/administração & dosagem
Neovascularização Fisiológica/efeitos dos fármacos
Paniculite/induzido quimicamente
Células-Tronco/efeitos dos fármacos
[Mh] Termos MeSH secundário: Tecido Adiposo/efeitos dos fármacos
Animais
Relação Dose-Resposta a Droga
Fibrose
Sobrevivência de Enxerto/imunologia
Fator Estimulador de Colônias de Granulócitos/efeitos adversos
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Neovascularização Fisiológica/imunologia
Paniculite/imunologia
Paniculite/patologia
Células-Tronco/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
143011-72-7 (Granulocyte Colony-Stimulating Factor)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170731
[St] Status:MEDLINE


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[PMID]:28698385
[Au] Autor:Liu Y; Chen Y; Zhang J; Liu Y; Zhang Y; Su Z
[Ad] Endereço:From the Molecular Medicine Research Center, West China Hospital, State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, Sichuan, China.
[Ti] Título:Retinoic acid receptor-related orphan receptor α stimulates adipose tissue inflammation by modulating endoplasmic reticulum stress.
[So] Source:J Biol Chem;292(34):13959-13969, 2017 Aug 25.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Adipose tissue inflammation has been linked to metabolic diseases such as obesity and type 2 diabetes. However, the molecules that mediate inflammation in adipose tissue have not been addressed. Although retinoic acid receptor-related orphan receptor α (RORα) is known to be involved in the regulation of inflammatory response in some tissues, its role is largely unknown in adipose tissue. Conversely, it is known that endoplasmic reticulum (ER) stress and unfolding protein response (UPR) signaling affect the inflammatory response in obese adipose tissue, but whether RORα regulates these processes remains unknown. In this study, we investigate the link between RORα and adipose tissue inflammation. We showed that the inflammatory response in macrophages or 3T3-L1 adipocytes stimulated by lipopolysaccharide, as well as adipose tissue in obese mice, markedly increased the expression of RORα. Adenovirus-mediated overexpression of RORα or treatment with the RORα-specific agonist SR1078 enhanced the expression of inflammatory cytokines and increased the number of infiltrated macrophages into adipose tissue. Furthermore, SR1078 up-regulated the mRNA expression of ER stress response genes and enhanced phosphorylations of two of the three mediators of major UPR signaling pathways, PERK and IRE1α. Finally, we found that alleviation of ER stress using a chemical chaperone followed by the suppression of RORα induced inflammation in adipose tissue. Our data suggest that RORα-induced ER stress response potentially contributes to the adipose tissue inflammation that can be mitigated by treatment with chemical chaperones. The relationships established here between RORα expression, inflammation, and UPR signaling may have implications for therapeutic targeting of obesity-related metabolic diseases.
[Mh] Termos MeSH primário: Adipócitos Brancos/metabolismo
Estresse do Retículo Endoplasmático
Macrófagos/metabolismo
Membro 1 do Grupo F da Subfamília 1 de Receptores Nucleares/metabolismo
Paniculite/metabolismo
Transdução de Sinais/efeitos dos fármacos
Resposta a Proteínas não Dobradas
[Mh] Termos MeSH secundário: Células 3T3-L1
Adipócitos Brancos/efeitos dos fármacos
Adipócitos Brancos/imunologia
Adipócitos Brancos/patologia
Animais
Fármacos Antiobesidade/farmacologia
Fármacos Antiobesidade/uso terapêutico
Benzamidas/farmacologia
Benzamidas/uso terapêutico
Estresse do Retículo Endoplasmático/efeitos dos fármacos
Regulação da Expressão Gênica/efeitos dos fármacos
Resistência à Insulina
Lipopolissacarídeos/toxicidade
Ativação de Macrófagos/efeitos dos fármacos
Macrófagos/efeitos dos fármacos
Macrófagos/imunologia
Macrófagos/patologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Membro 1 do Grupo F da Subfamília 1 de Receptores Nucleares/agonistas
Membro 1 do Grupo F da Subfamília 1 de Receptores Nucleares/genética
Obesidade/tratamento farmacológico
Obesidade/fisiopatologia
Paniculite/imunologia
Paniculite/patologia
Paniculite/prevenção & controle
Fenilbutiratos/farmacologia
Fenilbutiratos/uso terapêutico
Células RAW 264.7
Proteínas Recombinantes/química
Proteínas Recombinantes/metabolismo
Resposta a Proteínas não Dobradas/efeitos dos fármacos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Obesity Agents); 0 (Benzamides); 0 (Lipopolysaccharides); 0 (Nuclear Receptor Subfamily 1, Group F, Member 1); 0 (Phenylbutyrates); 0 (Recombinant Proteins); 0 (Rora protein, mouse); 0 (SR 1078); 7WY7YBI87E (4-phenylbutyric acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M117.782391


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[PMID]:28666424
[Au] Autor:Liao W; Xiao S; Yong J; Fan S; Fang W; Zheng Y; Liu J
[Ad] Endereço:Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, China.
[Ti] Título:Bilateral ptosis as first presentation of cytophagic histiocytic panniculitis: a case report.
[So] Source:BMC Ophthalmol;17(1):112, 2017 Jul 01.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cytophagic histiocytic panniculitis (CHP) is a rare form of nodular panniculitis that may progress to panniculitis-like T-cell lymphoma. We report a case of CHP that first manifested as bilateral ptosis, which is the first reported case of this presentation. CASE PRESENTATION: A 25-year-old woman without medical history was referred to the neurology department of our hospital for evaluation of bilateral ptosis. Three months previously, she suddenly complained of bilateral ptosis without apparent cause. Simultaneously, non-painful tender subcutaneous nodules and eschar-like skin lesions were observed on her extremities and trunk. A diagnosis of CHP was made based on skin biopsy from the left thigh showing lobular panniculitis, vasculitis, and adiponecrosis, with infiltration of inflammatory cells, including lymphocytes, histiocytes, and phagocytic histiocytes. Her condition continued to worsen with corticosteroid and immunosuppressive agent (thalidomide) treatment. Significant improvement was noticed after three cycles of chemotherapy of THP-COP (pirarubicin, cyclophosphamide, vincristine, and prednisolone). CONCLUSIONS: CHP is a rare condition whose clinical presentation may include bilateral ptosis and biopsy is required for diagnosis of CHP.
[Mh] Termos MeSH primário: Blefaroptose/etiologia
Histiócitos/fisiologia
Paniculite/complicações
[Mh] Termos MeSH secundário: Adulto
Biópsia
Blefaroptose/diagnóstico
Diagnóstico Diferencial
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Paniculite/diagnóstico
Pele/patologia
Tomografia Computadorizada por Raios X
Acuidade Visual
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170702
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0511-6


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[PMID]:28592018
[Au] Autor:Tao HH; Liu DH; Li XF
[Ti] Título:[A case report of anaplastic lymphoma kinase-negative anaplastic large-cell lymphoma characterized by skin panniculitis in children].
[So] Source:Zhonghua Er Ke Za Zhi;55(6):469-470, 2017 Jun 02.
[Is] ISSN:0578-1310
[Cp] País de publicação:China
[La] Idioma:chi
[Mh] Termos MeSH primário: Linfoma Anaplásico de Células Grandes
Receptores Proteína Tirosina Quinases
[Mh] Termos MeSH secundário: Criança
Seres Humanos
Paniculite
Pele
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases); EC 2.7.10.1 (anaplastic lymphoma kinase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0578-1310.2017.06.016


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[PMID]:28422890
[Au] Autor:Martin D; Joliat GR; Fournier P; Brunel C; Demartines N; Gié O
[Ad] Endereço:aDepartment of Visceral Surgery bInstitute of Pathology, University Hospital CHUV, Lausanne, Switzerland.
[Ti] Título:An unusual location of gouty panniculitis: A case report.
[So] Source:Medicine (Baltimore);96(16):e6733, 2017 Apr.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Gouty panniculitis, characterised by the deposition of monosodium urate crystals in subcutaneous tissue, is a rare clinical manifestation of gout. PATIENT CONCERNS: The case of a 67-year-old man is reported, who presented an erythematous nodule on the upper part of the right buttock suspicious for an abscess. This was in the context of chemotherapy for non-Hodgkin's lymphoma. DIAGNOSES: Histopathologic examination demonstrated gouty panniculitis. INTERVENTIONS: Because infection was suspected, an incision was performed. The lesion was found to be densely calcified and friable, without purulent discharge. Therefore, a surgical en-bloc resection was performed. OUTCOMES: The wound healed slowly initially due to a combination of malnutrition, chemotherapy and infection. A wound infection with Enterococcus faecium was treated with antibiotic therapy (carbapenem for seven days) and local therapy. At 6-week follow up the wound showed good granulation tissue and was healing well by secondary intention. The patient was instructed to continue anti-hyperuricaemic treatment. LESSONS SUBSECTIONS: In patients known to have long-standing hyperuricaemia and gout with nonspecific subcutaneous erythematous nodules, gouty panniculitis should be considered.
[Mh] Termos MeSH primário: Gota/complicações
Paniculite/etiologia
[Mh] Termos MeSH secundário: Idoso
Seres Humanos
Hiperuricemia
Masculino
Paniculite/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006733


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[PMID]:28329506
[Au] Autor:Martinez-Lopez A; Pérez-Lopez I; Sánchez-Cano D; Ruiz-Villaverde R
[Ad] Endereço:Dermatology Department, Dermatologist, Complejo Hospitalario de Granada, Granada, Spain.
[Ti] Título:Nódulos subcutáneos faciales de 3 meses de evolución.
[So] Source:Dermatol Online J;23(2), 2017 Feb 15.
[Is] ISSN:1087-2108
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Siliconomas are subcutaneous nodules that usuallyappear as a consequence of the migration of freesilicon implanted in other locations. They are morefrequent in women with abnormal breast implants,such as poly implant prostheses (PIP), but they may alsoappear after illegal injection of free silicone. We reporta 57-year-old woman who attended our Dermatologyclinic complaining of relapsing facial panniculitis ofunknown origin. After a thorough work-up, thesenodules were determined to be the consequence ofdermal filler made with fluid silicone, which had beeninjected 20 years prior. High frequency skin ultrasoundof one of the nodules showed a hyperechoic image,also known as "snowstorm," which was located in thesubcutaneous tissue. The disposition of silicone in thisplane obscures the view of any sonographic structurein the underlying plane. Cutaneous sonographyhas become one of the most useful non-invasivetechniques in diagnosis of filler complications andother inflammatory diseases. Combined treatmentwith prednisone and allopurinol was successful, withno recurrence after 1 year of follow-up.
[Mh] Termos MeSH primário: Preenchedores Dérmicos/efeitos adversos
Dermatoses Faciais/diagnóstico por imagem
Reação a Corpo Estranho/diagnóstico por imagem
Paniculite/diagnóstico por imagem
Silicones/efeitos adversos
Tela Subcutânea/diagnóstico por imagem
[Mh] Termos MeSH secundário: Alopurinol/uso terapêutico
Dermatoses Faciais/tratamento farmacológico
Dermatoses Faciais/patologia
Feminino
Reação a Corpo Estranho/tratamento farmacológico
Reação a Corpo Estranho/patologia
Depuradores de Radicais Livres/uso terapêutico
Glucocorticoides/uso terapêutico
Seres Humanos
Meia-Idade
Paniculite/tratamento farmacológico
Paniculite/patologia
Prednisona/uso terapêutico
Tela Subcutânea/patologia
Ultrassonografia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dermal Fillers); 0 (Free Radical Scavengers); 0 (Glucocorticoids); 0 (Silicones); 63CZ7GJN5I (Allopurinol); VB0R961HZT (Prednisone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE


  10 / 1437 MEDLINE  
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[PMID]:28323956
[Au] Autor:Qi X; Zhang B; Zhao Y; Li R; Chang HM; Pang Y; Qiao J
[Ad] Endereço:Reproductive Medical Center, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.
[Ti] Título:Hyperhomocysteinemia Promotes Insulin Resistance and Adipose Tissue Inflammation in PCOS Mice Through Modulating M2 Macrophage Polarization via Estrogen Suppression.
[So] Source:Endocrinology;158(5):1181-1193, 2017 May 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It has been shown that serum homocysteine (Hcy) levels are higher in women with polycystic ovary syndrome (PCOS). However, the specific role of hyperhomocysteinemia (HHcy) in the development of PCOS has never been reported. Adipose tissue inflammation is featured by the infiltration of macrophages, which plays a critical role in the pathogenesis of glucose and insulin intolerance. In this study, C57BL/6 mice were treated with dehydroepiandrosterone (DHEA) and/or a high methionine diet to induce PCOS and HHcy mice models. We showed that DHEA induced a PCOS-like phenotypes, irregular estrous cycles, weight gain, abnormal sex hormone production, glucose and insulin resistance, and polycystic ovaries. HHcy further intensified the effects DHEA on the metabolic, endocrinal, hormonal, and morphological changes in PCOS-like mice. In addition, HHcy attenuated the DHEA-induced increase in serum estrogen levels in mice. Furthermore, HHcy may exacerbate the insulin resistance in PCOS-like mice, most likely through modulating the macrophage M1/M2 polarization pathways via the suppression of estrogen. Most important, our clinical data showed that there were increases in serum Hcy levels in patients with PCOS. These findings deepen our understanding of the pathological roles of HHcy in the development of PCOS and provide a promising target for PCOS therapy in clinical application.
[Mh] Termos MeSH primário: Estrogênios/metabolismo
Hiper-Homocisteinemia/complicações
Resistência à Insulina
Macrófagos/fisiologia
Paniculite/etiologia
Síndrome do Ovário Policístico/complicações
[Mh] Termos MeSH secundário: Tecido Adiposo/metabolismo
Tecido Adiposo/patologia
Animais
Polaridade Celular/imunologia
Células Cultivadas
Regulação para Baixo
Estrogênios/sangue
Feminino
Hiper-Homocisteinemia/metabolismo
Inflamação/metabolismo
Inflamação/patologia
Ativação de Macrófagos
Camundongos
Camundongos Endogâmicos C57BL
Paniculite/metabolismo
Síndrome do Ovário Policístico/imunologia
Síndrome do Ovário Policístico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Estrogens)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00039



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