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[PMID]:29269541
[Ti] Título:More cases of Alabama rot confirmed in UK.
[So] Source:Vet Rec;181(25):668, 2017 12 23.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças do Cão/diagnóstico
Dermatopatias/veterinária
[Mh] Termos MeSH secundário: Animais
Cães
Estações do Ano
Dermatopatias/diagnóstico
Reino Unido
[Pt] Tipo de publicação:NEWS
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171223
[St] Status:MEDLINE


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[PMID]:28453238
[Au] Autor:Osman OT; Souid AK; Al-Mugaddam F; Eapen BR; Jafferany M
[Ad] Endereço:College of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Alain, Abu Dhabi 00000, United Arab Emirates. ossamao@uaeu.ac.ae.
[Ti] Título:Attentiveness of Dermatologists in the Middle East to Psychocutaneous Medicine.
[So] Source:Prim Care Companion CNS Disord;19(2), 2017 Apr 27.
[Is] ISSN:2155-7780
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Objective: Patients with skin diseases often have psychological problems and complications that require assessment and treatment. The main objective of this study was to explore attentiveness of dermatologists to psychiatric symptoms in their patients. Methods: A previously validated online questionnaire was used to explore the attitude and experience of dermatologists practicing in the Middle East toward the assessment of the psychiatric needs of their patients. The survey also inquired about awareness of available resources in dealing with psychodermatology. This online survey was conducted between October 2011 and October 2012. Results: Of 70 invited dermatologists, 57 (81%) completed the survey. Fifteen respondents (31%) received no training and had attended no educational events on psychodermatology. Only 19 respondents (33%) were able to identify psychodermatology as psychiatric components of skin diseases and dermatologic symptoms of psychiatric disorders. Twenty respondents (41%) reported frequent experience with psychodermatology, and 14 (28%) were "very comfortable" in diagnosing and treating psychodermatology patients. Twenty-two respondents (47%) recognized psychocutaneous involvement in 10% to 25% of their patients, while 18 (36%) recognized it in < 10% of their patients. Recognized diagnoses that required referral for psychiatric assessment included trichotillomania (34%), delusion of parasitosis (22%), depression (18%), dysmorphophobias (16%), dermatitis (10%), and venereophobia (10%). Forty-five respondents (90%) were unaware of psychodermatology resources. The majority of respondents expressed interest in education on depression, anxiety, adjustment disorders, and body dysmorphic disorder. Conclusions: Psychocutaneous involvements are common among dermatologic patients. A large number of the surveyed dermatologists had no training or education in psychodermatology. A lack of familiarity with patient and family resources on psychocutaneous conditions was also evident. These findings support the need for improvement in training and education in psychodermatology.
[Mh] Termos MeSH primário: Atenção
Dermatologistas/psicologia
Conhecimentos, Atitudes e Prática em Saúde
Transtornos Mentais/diagnóstico
Dermatopatias/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Transtornos Mentais/complicações
Meia-Idade
Oriente Médio
Dermatopatias/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.4088/PCC.16m02080


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[PMID]:29403334
[Au] Autor:Clark J; Randolph J; Sokol JA; Moore NA; Lee HBH; Nunery WR
[Ad] Endereço:Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, Kentucky.
[Ti] Título:Surgical approach to limiting skin contracture following protractor myectomy for essential blepharospasm.
[So] Source:Digit J Ophthalmol;23(4):8-12, 2017.
[Is] ISSN:1542-8958
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To report our experience with protractor myectomy in patients with benign essential blepharospasm who did not respond to serial botulinum toxin injection, and to describe intra- and postoperative techniques that limited skin contracture while also providing excellent functional and cosmetic results. Methods: The medical records of patients with isolated, benign, essential blepharospasm who underwent protractor myectomy from 2005 to 2008 by a single surgeon were reviewed retrospectively. The technique entailed operating on a single eyelid during each procedure, using a complete en bloc resection of all orbicularis tissue, leaving all eyelid skin intact at the time of surgery, and placing the lid under stretch with Frost suture and applying a pressure dressing for 5-7 days. Results: Data from 28 eyelids in 7 patients were included. Average follow-up was 21.5 months (range, 4-76 months). Of the 28 eyelids, 20 (71.4%) showed postoperative resolution of spasm, with no further need for botulinum toxin injections. In the 8 eyelids requiring further injections, the average time to injection after surgery was 194 days (range, 78-323 days), and the average number of injections was 12 (range, 2-23 injections). All but one eyelid had excellent cosmetic results, without signs of contracture; one eyelid developed postoperative skin contracture following premature removal of the Frost suture and pressure dressing because of concerns over increased intraocular pressure. Conclusions: In our patient cohort, this modified technique resulted in excellent cosmetic and functional results and limited postoperative skin contracture.
[Mh] Termos MeSH primário: Blefarospasmo/cirurgia
Contratura/cirurgia
Pálpebras/cirurgia
Músculos Oculomotores/cirurgia
Procedimentos Cirúrgicos Oftalmológicos/métodos
Complicações Pós-Operatórias/cirurgia
Dermatopatias/cirurgia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Contratura/diagnóstico
Contratura/etiologia
Pálpebras/patologia
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Procedimentos Cirúrgicos Oftalmológicos/efeitos adversos
Complicações Pós-Operatórias/diagnóstico
Complicações Pós-Operatórias/etiologia
Reoperação
Estudos Retrospectivos
Pele/patologia
Dermatopatias/diagnóstico
Dermatopatias/etiologia
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE
[do] DOI:10.5693/djo.01.2016.11.001


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[PMID]:29452656
[Au] Autor:Cartier H; Mazer JM
[Ad] Endereço:Groupe Laser de la Société française de dermatologie.
[Ti] Título:[Optimization of the healing process after laser procedure, except photorejuvenation].
[Ti] Título:Optimisation et gestion de la cicatrisation après acte laser, en dehors du photo-rajeunissement..
[So] Source:Ann Dermatol Venereol;143 Suppl 2:S26-S32, 2016 Dec.
[Is] ISSN:0151-9638
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:The use of Lasers in dermatology implies a crucial follow-up in order to optimize the final result and avoid any side effects. With the use of ablative laser devices, the initial phase is characterized by the development of crusts. These crusts necessitate the application of sterile ointments (regularly repeated throughout the day) as well as an antibiotic ointment two times a day. In a second step, comes a secondary inflammatory state, in the dermis, which is generally observed at the outset of all other laser treatments. The main purpose is to avoid it from being too sustained over time, but also to prevent the occurrence of post inflammatory hyperpigmentation. Obviously, a solar eviction will be strongly recommended. The risk being maximized with dark phototypes, the choice of the Laser, as well as its specific parameters will be specific and decisive.
[Mh] Termos MeSH primário: Cicatriz/prevenção & controle
Terapia a Laser/efeitos adversos
Complicações Pós-Operatórias/prevenção & controle
Dermatopatias/cirurgia
Cicatrização/fisiologia
[Mh] Termos MeSH secundário: Seres Humanos
Hiperpigmentação/prevenção & controle
Cuidados Pós-Operatórios/métodos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180218
[St] Status:MEDLINE


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[PMID]:28449275
[Au] Autor:Gisondi P; De Angelis G; Venturelli G; Girolomoni G
[Ad] Endereço:Department of Medicine, Section of Dermatology and Venereology, University of Verona, Verona, Italy.
[Ti] Título:Public perception of dermatology and dermatologists in Italy: results from a population-based national survey.
[So] Source:J Eur Acad Dermatol Venereol;31(12):2119-2123, 2017 Dec.
[Is] ISSN:1468-3083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The public perception of dermatology and dermatologists may be very relevant in guiding strategies for improving dermatologic care but it has been poorly investigated in Europe. OBJECTIVE: To investigate the public's perception of dermatology and dermatologists in Italy. METHODS: A representative sampling of Italian adults (n = 1500, aged 18-70 years), residing throughout the national territory was interviewed through a population-based telephone survey using a structured questionnaire. RESULTS: The majority of interviewed aged between 35 and 54 years (45%) and had an intermediate educational level (57%), were employed (56%), and had at least one child in the family (68%). 70% of the interviewed knew at least one skin disease, particularly psoriasis, dermatitis, urticaria, skin tumours and nevi. The general practitioner resulted to be the first healthcare provider to consult in the case of skin problems for 73% of surveyed, with only 27% referring directly the private dermatologist. The dermatologist was the main referral specialist for psoriasis, pruritus and skin tumours by 66%, 54% and 53% of the sample, respectively. The most common reason for dermatological consultation was the control of nevi. In the case of childhood dermatitis, 52% indicated the paediatrician and 38% the dermatologist as the reference specialist. Almost half of the surveyed turned out to have a trusted dermatologist to consult in the case of skin problems. Finally, among those visited at least one time by a dermatologist, 46% were promoters, that is, they would recommend their dermatologist to a friend (net promoter score, 27). CONCLUSIONS: The general population has a wide-ranging understanding of skin diseases and the central role of dermatologists in skin care. Patients are looking for technical competence and loyalty, because this lead to more trusted and satisfactory physician-patient relationship. Public campaigns may be relevant in increasing awareness on curability of common skin diseases.
[Mh] Termos MeSH primário: Dermatologistas
Dermatologia
Opinião Pública
Dermatopatias
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Feminino
Seres Humanos
Itália
Masculino
Meia-Idade
Autorrelato
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1111/jdv.14296


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[PMID]:29367526
[Au] Autor:Ishitsuka Y
[Ad] Endereço:Department of Dermatology, Faculty of Medicine, University of Tsukuba.
[Ti] Título:[The formation of skin barrier and defective barrier-associated skin diseases].
[So] Source:Nihon Rinsho Meneki Gakkai Kaishi;40(6):416-427, 2017.
[Is] ISSN:1349-7413
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:  Since the discovery of loss-of-function mutations in filaggrin (FLG) gene in atopic dermatitis (AD) individuals, significant attention has been paid against the skin barrier as an initial starting point of atopic march. Although FLG is a significant cornification-associated gene, skin barrier formation is a complex process mediated by an array of genes with specific functions. In this article, the mechanism of physical skin barrier formation is reviewed in detail, focusing on specific gene functions and inherited disorders caused by genetic aberrations. Additionally, the mechanism of percutaneous sensitization with environmental allergens in association with FLG-deficiency is reviewed in order to clarify the link between defective skin barrier and atopic march. Finally, updated knowledge of psoriasis pathophysiology in connection with genetic defect in skin barrier is reviewed. This article would provide a novel opportunity to understand the allergic/autoimmune disorders from the viewpoint of non-classical immune cells.
[Mh] Termos MeSH primário: Dermatopatias/genética
Dermatopatias/imunologia
Pele/imunologia
[Mh] Termos MeSH secundário: Dermatite Atópica/genética
Dermatite Atópica/imunologia
Seres Humanos
Proteínas de Filamentos Intermediários/genética
Mutação com Perda de Função
Psoríase/genética
Psoríase/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Intermediate Filament Proteins); 0 (filaggrin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.2177/jsci.40.416


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[PMID]:29311458
[Au] Autor:Sasaoka S; Hatahira H; Hasegawa S; Motooka Y; Fukuda A; Naganuma M; Umetsu R; Nakao S; Shimauchi A; Ueda N; Hirade K; Iguchi K; Nakamura M
[Ad] Endereço:Laboratory of Drug Informatics, Gifu Pharmaceutical University.
[Ti] Título:[Adverse Event Trends Associated with Over-the-counter Combination Cold Remedy: Data Mining of the Japanese Adverse Drug Event Report Database].
[So] Source:Yakugaku Zasshi;138(1):123-134, 2018.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:OTC combination cold remedies are widely used in Japan. In the present study, we aimed to evaluate the adverse event profiles of OTC combination cold remedy based on the components using the Japanese Adverse Drug Event Report (JADER) database. The JADER database contained 430587 reports between April 2004 and November 2016. 1084 adverse events associated with the use of OTC combination cold remedy were reported. Reporting odds ratio (ROR) was used to detect safety signals. The ROR values for "skin and subcutaneous tissue disorders", "hepatobiliary disorders", and "immune system disorders" stratified by system organ class of the Medical Dictionary for Regulatory Activities (MedDRA) were 9.82 (8.71-11.06), 2.63 (2.25-3.07), and 3.13 (2.63-3.74), respectively. OTC combination cold remedy containing acetaminophen exhibited a significantly higher reporting ratio for "hepatobiliary disorders" than OTC combination cold remedy without acetaminophen. We demonstrated the potential risk of OTC combination cold remedy in a real-life setting. Our results suggested that the monitoring of individuals using OTC combination cold remedy is important.
[Mh] Termos MeSH primário: Acetaminofen/efeitos adversos
Sistemas de Notificação de Reações Adversas a Medicamentos
Mineração de Dados
Bases de Dados Factuais
Uso de Medicamentos/estatística & dados numéricos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia
Medicamentos sem Prescrição/efeitos adversos
[Mh] Termos MeSH secundário: Acetaminofen/administração & dosagem
Sistemas de Notificação de Reações Adversas a Medicamentos/estatística & dados numéricos
Doenças Biliares/induzido quimicamente
Doenças Biliares/epidemiologia
Doença Hepática Induzida por Substâncias e Drogas/epidemiologia
Doença Hepática Induzida por Substâncias e Drogas/etiologia
Combinação de Medicamentos
Doenças do Sistema Imune/induzido quimicamente
Doenças do Sistema Imune/epidemiologia
Japão/epidemiologia
Medicamentos sem Prescrição/administração & dosagem
Razão de Chances
Risco
Dermatopatias/induzido quimicamente
Dermatopatias/epidemiologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Nonprescription Drugs); 362O9ITL9D (Acetaminophen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.17-00172


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[PMID]:28468901
[Au] Autor:Janssen LMA; Tostmann A; Hopman J; Liem KD
[Ad] Endereço:Department of Neonatology, Radboud University Medical Centre, Nijmegen, The Netherlands.
[Ti] Título:0.2% chlorhexidine acetate as skin disinfectant prevents skin lesions in extremely preterm infants: a preliminary report.
[So] Source:Arch Dis Child Fetal Neonatal Ed;103(2):F97-F100, 2018 Mar.
[Is] ISSN:1468-2052
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The skin disinfectant '0.5% chlorhexidine gluconate in 70% alcohol' (0.5% CHG-70% alc) may cause skin lesions in extremely preterm infants (gestational age <26 weeks). In April 2013, 0.2% chlorhexidine gluconate solution in acetate (0.2% CHG-acetate) was introduced as skin disinfectant for extremely preterm infants in our neonatal intensive care units. We aimed to compare the incidence of skin lesions and central line-associated bloodstream infection (CLABSI) among extremely preterm infants when using 0.5% CHG-70% alc and 0.2% CHG-acetate. DESIGN: Retrospective pre-post comparison cohort study. PATIENTS: All electronic patient records of extremely preterm infants born between January 2011-March 2013 ('0.5% CHG-70% alc' cohort) and April 2013-October 2015 ('0.2% CHG-acetate' cohort) were reviewed. MAIN OUTCOME MEASURES: The incidence of skin lesions and CLABSI. Skin lesions were defined as the presence of erythema, blisters, excoriation, oedema or induration. CLABSI was defined according to the definition of the US Centers for Disease Control and Prevention. RESULTS: The incidence of skin lesions was 22% (95% CI 11% to 37%) in the '0.5% CHG-70% alc' cohort (n=41) and 5% (95% CI 1% to 15%; p=0.02) in the '0.2% CHG-acetate' cohort (n=41). The incidence of CLABSI was the same in both groups (28%; 95% CI 14% to 46% in '0.5% CHG-70% alc' vs 27%; 95% CI 14% to 44% in '0.2% CHG-acetate'; p=0.98). CONCLUSIONS: Using 0.2% CHG-acetate as skin disinfectant in extremely preterm infants resulted in statistically significant reduction of skin lesions, without increasing the risk of CLABSI as compared with 0.5% CHG-70% alc.
[Mh] Termos MeSH primário: Anti-Infecciosos Locais/administração & dosagem
Infecções Relacionadas a Cateter/prevenção & controle
Clorexidina/análogos & derivados
Infecção Hospitalar/prevenção & controle
Lactente Extremamente Prematuro
Dermatopatias/prevenção & controle
[Mh] Termos MeSH secundário: Cateteres Venosos Centrais
Clorexidina/administração & dosagem
Registros Eletrônicos de Saúde
Feminino
Idade Gestacional
Seres Humanos
Recém-Nascido
Unidades de Terapia Intensiva Neonatal
Masculino
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local); MOR84MUD8E (chlorhexidine gluconate); R4KO0DY52L (Chlorhexidine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1136/archdischild-2017-312694


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[PMID]:29429508
[Au] Autor:Ezzedine K
[Ad] Endereço:Service de dermatologie, hôpital Henri-Mondor et EpiDermE, EA 7379, université Paris-Est Créteil Val-de-Marne, 94010, Créteil, France. Electronic address: haled.ezzedine@aphp.fr.
[Ti] Título:[What's new in dermatological therapy?]
[Ti] Título:Quoi de neuf en thérapeutique dermatologique ?.
[So] Source:Ann Dermatol Venereol;143 Suppl 3:S37-S42, 2016 Dec.
[Is] ISSN:0151-9638
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:Over the last year there has been major publications related to therapeutic trials in infectious dermatology, not only with regard to Herpes zoster subunit vaccine but also for the treatment of uncomplicated abscesses or scabies. In addition, biological treatments continue to be on the forefront, not only in the treatment of psoriasis but also in other chronic inflammatory dermatologic diseases such as atopic dermatitis and hidradenitis suppurativa, two diseases that significantly impact quality of life and for which there are to date, few therapeutic alternatives in moderate to severe forms. In addition, the treatment of cyclin-resistant papulopustular rosacea was also the subject of a large French controlled randomized controlled trial that could modify our therapeutic approach by the use of isotretinoin. Finally, the prevention of rashes induced by erlotinib with oral doxycyline is also part of this 2016 "what's new in dermatological therapeutics".
[Mh] Termos MeSH primário: Dermatopatias/tratamento farmacológico
[Mh] Termos MeSH secundário: Adalimumab/uso terapêutico
Antibacterianos/uso terapêutico
Anti-Inflamatórios/uso terapêutico
Anticorpos Monoclonais/uso terapêutico
Fármacos Dermatológicos/uso terapêutico
Dermatologia
Cloridrato de Erlotinib/uso terapêutico
Vacina contra Herpes Zoster
Seres Humanos
Proteína Antagonista do Receptor de Interleucina 1/uso terapêutico
Isotretinoína/uso terapêutico
Piperidinas/uso terapêutico
Inibidores de Proteínas Quinases/uso terapêutico
Pirimidinas/uso terapêutico
Pirróis/uso terapêutico
Dermatopatias/diagnóstico
Combinação Trimetoprima e Sulfametoxazol/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-Inflammatory Agents); 0 (Antibodies, Monoclonal); 0 (Dermatologic Agents); 0 (Herpes Zoster Vaccine); 0 (Interleukin 1 Receptor Antagonist Protein); 0 (Piperidines); 0 (Protein Kinase Inhibitors); 0 (Pyrimidines); 0 (Pyrroles); 0 (SAR231893); 8064-90-2 (Trimethoprim, Sulfamethoxazole Drug Combination); 87LA6FU830 (tofacitinib); DA87705X9K (Erlotinib Hydrochloride); EH28UP18IF (Isotretinoin); FYS6T7F842 (Adalimumab)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


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[PMID]:29429507
[Au] Autor:Léauté-Labrèze C
[Ad] Endereço:Unité de dermatologie pédiatrique et centre de référence des maladies rares de la peau, hôpital Pellegrin-Enfants, CHU de Bordeaux, 33076 Bordeaux Cedex, France. Electronic address: christine.labreze@chu-bordeaux.fr.
[Ti] Título:[What's new in pediatric dermatology?]
[Ti] Título:Quoi de neuf en dermatologie pédiatrique ?.
[So] Source:Ann Dermatol Venereol;143 Suppl 3:S29-S36, 2016 Dec.
[Is] ISSN:0151-9638
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:The association of a birth defect and a segmental hemangioma is well established, a consensus concerning evaluation and monitoring of infants with PHACE or LUMBAR syndromes has been published. The efficacy of propranolol in infantile hemangioma is proven; however there were still unresolved issues concerning the safety in children; after 8 years of use on thousands of children safety data collection did not show any unexpected side effects. Topical treatment of infantile hemangiomas with beta-blockers, such as timolol, is very popular, but recent publications revealed a significant systemic absorption that could be responsible for severe side effects, such as bradycardia, in low birthweight infants. As a consequence, this therapeutic option should be considered with caution. In the last 2 years mTOR inhibitors have been tested in low-flow vascular malformations with varying success, but progress remains to be done in the treatment of vascular abnormalities. Today, genetics has led to advances in the understanding of the pathophysiology and in the future targeted therapies could probably be feasible. Skin barrier deficiency is responsible for the development of allergic phenomena in atopic patients, since it has been shown that sensibilisation, even to food, could probably be induced by skin contact. Unfortunately, the topical treatment with crisaborole, a phosphodiesterase 4 inhibitor, does not look like a revolution in children atopic dermatitis, its efficacy seems equivalent to emollient application. In the field of infectious diseases, changes in viral outbreaks are the most reported. Furthermore epidemic Zika virus, enteroviruses are responsible for expanded dermatological manifestations and also severe meningoencephalitis. Paraviral character of various eruptions, such as gloves and socks syndrome or eruptive pseudoangiomatosis is challenged.
[Mh] Termos MeSH primário: Dermatopatias
[Mh] Termos MeSH secundário: Coartação Aórtica/terapia
Doenças Autoimunes/genética
Criança
Dermatologia
Anormalidades do Olho/terapia
Hipersensibilidade Alimentar/imunologia
Hemangioma/terapia
Seres Humanos
Síndromes Neurocutâneas/terapia
Pediatria
Fator de Transcrição STAT3/genética
Dermatopatias/diagnóstico
Dermatopatias/etiologia
Dermatopatias/terapia
Fenômenos Fisiológicos da Pele
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (STAT3 Transcription Factor); 0 (STAT3 protein, human)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE



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