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[PMID]: 28782985 [Au] Autor: Jabbar SB; Lynch B; Seiler S; Hwang H; Sahoo S [Ad] Endereço: From the Departments of Pathology and Laboratory Medicine (Drs Jabbar, Lynch, Hwang, and Sahoo), and Radiology (Dr Seiler), University of Texas Southwestern Medical Center, Dallas. Dr Jabbar and Dr Lynch contributed equally to the study. [Ti] Título: Pathologic Findings of Breast Lesions Detected on Magnetic Resonance Imaging. [So] Source: Arch Pathol Lab Med;141(11):1513-1522, 2017 Nov. [Is] ISSN: 1543-2165 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: CONTEXT: - Breast magnetic resonance imaging (MRI) is now used routinely for high-risk screening and in the evaluation of the extent of disease in newly diagnosed breast cancer patients. Morphologic characteristics and the kinetic pattern largely determine how suspicious a breast lesion is on MRI. Because of its high sensitivity, MRI identifies a large number of suspicious lesions. However, the low to moderate specificity and the additional cost have raised questions regarding its frequent use. OBJECTIVES: - To identify the pathologic entities that frequently present as suspicious enhancing lesions and to identify specific MRI characteristics that may be predictive of malignancy. DESIGN: - One hundred seventy-seven MRI-guided biopsies from 152 patients were included in the study. The indication for MRI, MRI features, pathologic findings, and patient demographics were recorded. The MRI findings and the pathology slides were reviewed by a dedicated breast radiologist and breast pathologists. RESULTS: - Seventy-one percent (126 of 177) of MRI-guided breast biopsies were benign, 11% (20 of 177) showed epithelial atypia, and 18% (31 of 177) showed malignancy. The vast majority (84%; 62 of 74) of MRI lesions with persistent kinetics were benign. However, 57% (17 of 30) of lesions with washout kinetics and 65% (62 of 95) of mass lesions were also benign. CONCLUSIONS: - Magnetic resonance imaging detects malignancies undetected by other imaging modalities but also detects a wide variety of benign lesions. Benign and malignant lesions identified by MRI share similar morphologic and kinetic features, necessitating biopsy for histologic confirmation. [Mh] Termos MeSH primário: Neoplasias da Mama/patologia Mama/patologia Meios de Contraste/farmacocinética [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Biópsia com Agulha de Grande Calibre Mama/diagnóstico por imagem Neoplasias da Mama/diagnóstico por imagem Detecção Precoce de Câncer Feminino Doença da Mama Fibrocística/diagnóstico por imagem Doença da Mama Fibrocística/patologia Seguimentos Seres Humanos Hiperplasia Interpretação de Imagem Assistida por Computador Biópsia Guiada por Imagem Imagem por Ressonância Magnética Meia-Idade Gradação de Tumores Estudos Retrospectivos Sensibilidade e Especificidade Distribuição Tecidual Carga Tumoral [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Contrast Media) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171106 [Lr] Data última revisão: 171106 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170808 [St] Status: MEDLINE [do] DOI: 10.5858/arpa.2016-0552-OA

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[PMID]: 28173727 [Au] Autor: Dietzel M; Kaiser CG; Wenkel E; Clauser P; Uder M; Schulz-Wendtland R; Baltzer PA [Ad] Endereço: 1 Department of Radiology, University Hospital Erlangen-Nürnberg, Erlangen, Germany. [Ti] Título: Differentiation of ductal carcinoma in situ versus fibrocystic changes by magnetic resonance imaging: are there pathognomonic imaging features? [So] Source: Acta Radiol;58(10):1206-1214, 2017 Oct. [Is] ISSN: 1600-0455 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Background In breast magnetic resonance imaging (MRI), the diagnosis of ductal carcinoma in situ (DCIS) remains controversial; the most challenging cause of false-positive DCIS diagnosis is fibrocystic changes (FC). Purpose To search for typical and pathognomonic patterns of DCIS and FC using a standard clinical MRI protocol. Material and Methods Consecutive patients scheduled for breast MRI (standardized protocols @ 1.5T: dynamic-T1-GRE before/after Gd-DTPA [0.1 mmol/kg body weight (BW)]; T1-TSE), with subsequent pathological sampling, were investigated. Sixteen MRI descriptors were prospectively assessed by two experienced radiologists in consensus (blinded to pathology) and explored in patients with DCIS (n = 77) or FC (n = 219). Univariate and multivariate statistics were performed to identify the accuracy of descriptors (alone, combined). Furthermore, pathognomonic descriptor-combinations with an accuracy of 100% were explored (χ statistics; decision trees). Results Six breast MRI descriptors significantly differentiated DCIS from FC ( P < 0.05; odds ratio < 7.9). Pathognomonic imaging features were present in 33.8% (n = 100) of all cases allowing the identification of 42.9% of FC (n = 94). Conclusion Pathognomonic patterns of DCIS and FC were frequently observed in a standard clinical MRI protocol. Such imaging patterns could decrease the false-positive rate of breast MRI and hence might help to decrease the number of unnecessary biopsies in this clinically challenging subgroup. [Mh] Termos MeSH primário: Neoplasias da Mama/diagnóstico por imagem Carcinoma Intraductal não Infiltrante/diagnóstico por imagem Doença da Mama Fibrocística/diagnóstico por imagem Imagem por Ressonância Magnética [Mh] Termos MeSH secundário: Meios de Contraste Estudos Transversais Diagnóstico Diferencial Feminino Gadolínio DTPA Seres Humanos Aumento da Imagem/métodos Meia-Idade Estudos Prospectivos [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Contrast Media); K2I13DR72L (Gadolinium DTPA) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170901 [Lr] Data última revisão: 170901 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170209 [St] Status: MEDLINE [do] DOI: 10.1177/0284185117690420

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[PMID]: 28109002 [Au] Autor: Yao JP; Hao YZ; Chang Q; Geng CY; Chen Y; Zhao WP; Song Y; Zhou X [Ad] Endereço: Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China. [Ti] Título: Value of Ultrasonographic Features for Assessing Malignant Potential of Complex Cystic Breast Lesions. [So] Source: J Ultrasound Med;36(4):699-704, 2017 Apr. [Is] ISSN: 1550-9613 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: OBJECTIVES: To assess the value of ultrasonography (US) features for determining the malignant potential of complex cystic lesions. METHODS: Seventy-nine complex cystic lesions were reviewed retrospectively. They were classified into four types according to US features in type I, the masses have a thick outer wall, thick internal septa, or both; in type II, the masses are an intracystic type with one or more discrete solid mural lesions within a cyst; in type III, the masses contain mixed cystic and solid components and are at least 50% cystic portion in a mass; in type IV, there are predominantly (at least 50%) solid masses with eccentric or central cystic foci. Positive predictive values were calculated for all types. RESULTS: The frequency of malignancy was higher among type III and IV lesions than among the other two types. Lesions with a diameter greater than or equal to 20 mm, margins not circumscribed, resistance index greater than or equal to 0.7, and axillary abnormal nodes had a high probability of malignancy. CONCLUSIONS: US is an important adjunct to evaluate the malignant potential of complex cystic lesions. [Mh] Termos MeSH primário: Neoplasias da Mama/diagnóstico por imagem Doença da Mama Fibrocística/diagnóstico por imagem Ultrassonografia Mamária/métodos [Mh] Termos MeSH secundário: Adolescente Adulto Idoso Cistos/diagnóstico por imagem Diagnóstico Diferencial Feminino Seres Humanos Meia-Idade Reprodutibilidade dos Testes Estudos Retrospectivos Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171004 [Lr] Data última revisão: 171004 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170122 [St] Status: MEDLINE [do] DOI: 10.7863/ultra.16.05012

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[PMID]: 27840910 [Au] Autor: Gomulkiewicz A; Jablonska K; Pula B; Grzegrzolka J; Borska S; Podhorska-Okolow M; Wojnar A; Rys J; Ambicka A; Ugorski M; Zabel M; Dziegiel P [Ad] Endereço: Department of Histology and Embryology, Wroclaw Medical University, Wroclaw, Poland. [Ti] Título: Expression of metallothionein 3 in ductal breast cancer. [So] Source: Int J Oncol;49(6):2487-2497, 2016 Dec. [Is] ISSN: 1791-2423 [Cp] País de publicação: Greece [La] Idioma: eng [Ab] Resumo: Metallothionein 3 (MT-3) has the ability to regulate the growth of nerve cells, but the significance of MT-3 expression outside the central nervous system and its participation in carcinogenesis have not yet been clarified. The aim of our study was to investigate the expression of MT-3 in ductal breast cancer and to determine its relationship with well-defined clinicopathological factors in this type of tumor. The study was conducted on 134 cases of invasive ductal breast carcinoma (IDC), 42 samples of non-malignant breast tissue (NMBT), and 26 cases of mastopathy. Moreover, selected breast cancer cell lines (MCF-7, SKBR-3, MDA-MB-231, BO2) and normal human breast epithelial cells (hTERT-HME1) were used. The expression of MT-3 was examined on the protein level using immunohistochemistry and on the mRNA level using real-time PCR. It was shown that the MT-3 protein in cells of IDC and mastopathy appeared in the cytoplasm as well as in the cell nuclei. Both the cytoplasmic and nuclear expression of MT-3 was significantly lower in IDC than in the mastopathies (p<0.0001 and p<0.001). However, no significant correlation was demonstrated between the level of MT-3 protein and the studied clinicopathological factors. The mRNA expression of MT-3 in IDC was also lower than in non­malignant breast tissue (p<0.0001). Furthermore, in the cases of IDC with lymph node metastasis, the level of MT-3 mRNA was significantly lower than in the cases without metastasis (p=0.0199). The expression of MT-3 mRNA in breast cancer cell lines was significantly lower than in the normal human breast epithelial cell line (p<0.001). These results suggest that MT-3 may play a role in the malignant transformation of breast epithelial cells and in tumor progression. [Mh] Termos MeSH primário: Neoplasias da Mama/patologia Carcinoma Ductal de Mama/patologia Doença da Mama Fibrocística/patologia Proteínas do Tecido Nervoso/metabolismo [Mh] Termos MeSH secundário: Linhagem Celular Tumoral Núcleo Celular/metabolismo Citoplasma/metabolismo Feminino Seres Humanos Imuno-Histoquímica Células MCF-7 Meia-Idade Proteínas do Tecido Nervoso/biossíntese Proteínas do Tecido Nervoso/genética Reação em Cadeia da Polimerase em Tempo Real [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Nerve Tissue Proteins); 0 (growth inhibitory factor) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170622 [Lr] Data última revisão: 170622 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161115 [St] Status: MEDLINE [do] DOI: 10.3892/ijo.2016.3759

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[PMID]: 27684975 [Au] Autor: Asirvatham JR; Falcone MM; Kleer CG [Ad] Endereço: From the Departments of Pathology and Laboratory Medicine (Drs Asirvatham and Kleer) and the Comprehensive Cancer Center (Dr Kleer), University of Michigan Hospital and Health Systems, Ann Arbor; and Department of Pathology, CEMIC University Hospital, Buenos Aires, Argentina (Dr Falcone). [Ti] Título: Atypical Apocrine Adenosis: Diagnostic Challenges and Pitfalls. [So] Source: Arch Pathol Lab Med;140(10):1045-51, 2016 Oct. [Is] ISSN: 1543-2165 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Apocrine change in the breast is an extremely common finding. In most cases, the benign or malignant nature of the lesion is easily recognized. Apocrine adenosis is used to describe sclerosing adenosis with apocrine change. The term apocrine atypia is used when there is significant cytologic atypia in apocrine cells, characterized by a 3-fold nuclear enlargement, prominent/multiple nucleoli, and hyperchromasia. Atypical apocrine adenosis is diagnosed when apocrine adenosis and apocrine atypia are superimposed. However, there are no definite criteria to distinguish atypical apocrine adenosis from apocrine ductal carcinoma in situ. Immunohistochemical markers can be confounding and may lead to erroneous diagnoses. Atypical apocrine features in sclerosing lesions may be misinterpreted as invasive carcinoma if the underlying lesion is not recognized. In the absence of definite features of malignancy, the diagnosis of apocrine ductal carcinoma in situ may be extremely difficult. In the present article, we review atypical apocrine adenosis focusing on diagnostic challenges and their implications on clinical management. [Mh] Termos MeSH primário: Glândulas Apócrinas/patologia Mama/patologia Doença da Mama Fibrocística/diagnóstico Lesões Pré-Cancerosas/diagnóstico [Mh] Termos MeSH secundário: Glândulas Apócrinas/metabolismo Mama/metabolismo Proteínas de Transporte/metabolismo Diagnóstico Diferencial Feminino Doença da Mama Fibrocística/metabolismo Glicoproteínas/metabolismo Seres Humanos Imuno-Histoquímica Metaplasia Lesões Pré-Cancerosas/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Carrier Proteins); 0 (Glycoproteins); 0 (PIP protein, human) [Em] Mês de entrada: 1702 [Cu] Atualização por classe: 170817 [Lr] Data última revisão: 170817 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 160930 [St] Status: MEDLINE [do] DOI: 10.5858/arpa.2016-0238-RA

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[PMID]: 27649945 [Au] Autor: Hou Y; Chaudhary S; Gao FF; Li Z [Ad] Endereço: Department of Pathology, Ohio State University Wexner Medical Center, Columbus, OH. [Ti] Título: Surgical follow-up results for apocrine adenosis and atypical apocrine adenosis diagnosed on breast core biopsy. [So] Source: Ann Diagn Pathol;24:4-6, 2016 Oct. [Is] ISSN: 1532-8198 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Apocrine adenosis (AA) and atypical apocrine adenosis (AAA) are uncommon findings in breast biopsies that may be misinterpreted as carcinoma. The clinical significance and risk implications of AAA diagnosed on core biopsy are not well established. This study aimed to determine the frequency of carcinoma on follow-up excision in patients with a diagnosis of AA or AAA on core biopsy. Forty-one breast core biopsies of AA (n=29) and AAA (n=12) were identified during a study period of 12 years. Of the 41 core biopsies with AA or AAA, 10 biopsies showed coexisting/concurrent atypical hyperplasia or carcinoma. In the absence of coexisting/concurrent atypical hyperplasia or carcinoma in core biopsy, none of the follow-up excision specimens after a diagnosis of AA or AAA showed ductal carcinoma in situ or invasive carcinoma. In conclusion, AA or AAA by itself is an uncommon core biopsy diagnosis that may not require surgical excision. [Mh] Termos MeSH primário: Neoplasias da Mama/patologia Mama/patologia Carcinoma Ductal de Mama/patologia Carcinoma Intraductal não Infiltrante/patologia Doença da Mama Fibrocística/patologia Lesões Pré-Cancerosas/patologia [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Biópsia com Agulha de Grande Calibre/métodos Neoplasias da Mama/diagnóstico Carcinoma Intraductal não Infiltrante/diagnóstico Feminino Doença da Mama Fibrocística/diagnóstico Seguimentos Seres Humanos Hiperplasia/diagnóstico Hiperplasia/patologia Mamografia/métodos Meia-Idade Lesões Pré-Cancerosas/diagnóstico [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1703 [Cu] Atualização por classe: 170306 [Lr] Data última revisão: 170306 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160922 [St] Status: MEDLINE

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[PMID]: 27648624 [Au] Autor: Ferdousee I; Arafat SM; Ahmed Z [Ti] Título: An Adolescent Girl with Giant Fibroadenoma - A Case Report. [So] Source: Pol Przegl Chir;88(4):218-20, 2016 Sep 01. [Is] ISSN: 2299-2847 [Cp] País de publicação: Poland [La] Idioma: eng [Ab] Resumo: Though fibroadenoma is the most common benign tumor of the breast and is more common under the age of 30, giant fibroadenoma is rare representing less than 4% of all fibroadenomas. A 12 years old girl presented with rapidly enlarging well-circumscribed firm, non-tender mass in right breast for 2 months which was painless and with no history of trauma, nipple discharge, fever, anorexia, weight loss or axillary lymphadenopathy. There was no family history of neoplasms. Clinically, the lump was about 12 × 12 cm and not fixed to skin or underlying structures with the absence of nipple retraction or discharge. There was no axillary lymphadenopathy. Fine needle aspiration cytology showed a benign proliferative breast disease. Total excision of mass was done preserving nipple and areola having weight of 535 gm with histopathological features suggestive of giant fibroadenoma. Giant fibroadenoma is a benign breast disease that may mimic rare malignant lesion. So, breast and nipple conserving surgery should always be performed irrespective of size of tumor as in this case. [Mh] Termos MeSH primário: Fibroadenoma/diagnóstico Fibroadenoma/cirurgia Doença da Mama Fibrocística/diagnóstico Doença da Mama Fibrocística/cirurgia [Mh] Termos MeSH secundário: Criança Feminino Seres Humanos Polônia Resultado do Tratamento [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170424 [Lr] Data última revisão: 170424 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160921 [St] Status: MEDLINE

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[PMID]: 27597384 [Au] Autor: Zetterlund L; Gabrielson S; Axelsson R; de Boniface J; Frisell J; Olsson A; Celebioglu F [Ad] Endereço: Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Sweden; Department of Surgery, Södersjukhuset, 118 83 Stockholm, Sweden. Electronic address: linda.holmstrand-zetterlund@sodersjukhuset.se. [Ti] Título: Impact of previous surgery on sentinel lymph node mapping: Hybrid SPECT/CT before and after a unilateral diagnostic breast excision. [So] Source: Breast;30:32-38, 2016 Dec. [Is] ISSN: 1532-3080 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: BACKGROUND: Earlier studies have shown conflicting results regarding the accuracy of sentinel lymph node biopsy after previous breast surgery, especially after a surgical biopsy. PURPOSE: To compare lymph drainage patterns before and after a diagnostic unilateral surgical biopsy using the exact anatomical localisation of sentinel lymph nodes defined by SPECT/CT. MATERIAL AND METHODS: Thirty-seven women planned for unilateral surgical excision of an unsuspicious breast lesion were prospectively examined between September 2011 and January 2015. Hybrid SPECT/CT lymphoscintigraphy of the thorax and neck region with bilateral subareolar injections of Tc-Nanocoll was performed one week before and six weeks after surgery. The non-operated side served as a control. The primary outcome measure was the concordance between pre- and postoperative number and localisation of sentinel lymph nodes. RESULTS: Sentinel lymph node detection rate with SPECT/CT on operated sides was 91.9 per cent (34 of 37 procedures), to be compared with a detection rate of 93.7 per cent on all non-operated sides (104 of 111 procedures, P = 0.771). Partial or total concordance regarding the localisation and number of sentinel lymph nodes was 85.7 per cent (30 out of 35) on operated and 88.9 per cent (32 out of 36 patients) on non-operated breast sides (P = 0.735). CONCLUSION: Breast surgery slightly decreased the concordance between pre- and postoperative sentinel lymph nodes, but this finding was not statistically significant. Our results thus support that it is feasible to perform a sentinel lymph node biopsy after previous breast excisional surgery with an acceptable level of safety. [Mh] Termos MeSH primário: Neoplasias da Mama/cirurgia Carcinoma Intraductal não Infiltrante/cirurgia Fibroadenoma/cirurgia Doença da Mama Fibrocística/cirurgia Mastectomia Segmentar/estatística & dados numéricos Papiloma/cirurgia Biópsia de Linfonodo Sentinela/métodos Linfonodo Sentinela/diagnóstico por imagem [Mh] Termos MeSH secundário: Adolescente Adulto Idoso Axila Biópsia/estatística & dados numéricos Neoplasias da Mama/patologia Carcinoma Intraductal não Infiltrante/patologia Dilatação Patológica/patologia Dilatação Patológica/cirurgia Feminino Fibroadenoma/patologia Doença da Mama Fibrocística/patologia Seres Humanos Hiperplasia Linfocintigrafia Glândulas Mamárias Humanas/patologia Glândulas Mamárias Humanas/cirurgia Meia-Idade Papiloma/patologia Estudos Prospectivos Compostos Radiofarmacêuticos Linfonodo Sentinela/patologia Tomografia Computadorizada com Tomografia Computadorizada de Emissão de Fóton Único Agregado de Albumina Marcado com Tecnécio Tc 99m Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Radiopharmaceuticals); 0 (Technetium Tc 99m Aggregated Albumin); 0 (technetium Tc 99m nanocolloid) [Em] Mês de entrada: 1703 [Cu] Atualização por classe: 170313 [Lr] Data última revisão: 170313 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160907 [St] Status: MEDLINE

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[PMID]: 27483712 [Au] Autor: Carauleanu A; Socolov R; Rugina V; Gabia O; Carauleanu DM; Lupascu IA; Socolov D [Ti] Título: COMPARISONS BETWEEN THE NON-PROLIFERATIVE AND PROLIFERATIVE THERAPY IN FIBROCYSTIC MASTOSIS. [So] Source: Rev Med Chir Soc Med Nat Iasi;120(2):321-7, 2016 Apr-Jun. [Is] ISSN: 0048-7848 [Cp] País de publicação: Romania [La] Idioma: eng [Ab] Resumo: AIM: Fibrocystic mastosis (FCM) is the most frequent benign breast lesion. Most treatments for fibrocystic mastosis are: hormonl, with beneficial results and non-hormonal, with fluctuating results. MATERIAL AND METHODS: A number of 210 cases were studied, which were divided into 7 groups. The study lasted for 9 months and it was carried out on the basis of a personal examination sheet. The following were monitored: age groups, mastodynia, reducing breast nodules, a significant reduction in the volume of the mastosic cysts, reducion of the fibrous tissue, medication tolerance. RESULTS: Mastodynia has declined by 90% in the cases treated with Tamoxifen and Danazol, by 70% in the case of Lynestrenol and Bromocriptine, by 50% in the 15 patients who were given Utrogestan. Knowing the advantages and disadvantages of drugs (contraindications, side effects), age category, breast pain reduction, antiproliferative activity, tolerability, relapse allow us to assess the benefit-risk. Even in those circumstances that remained incompletely clarified for objective reasons, related to the inaccurate/incorrect reporting by the patients, there is a significant difference (p < 0.05) between the frequency of relapses following the treatment with Tamoxifen and the other categories of drugs who were administered. CONCLUSIONS: Our study shows that in the groups that were administered Logest, Utrogestan and Bromocriptine, only antalgic effects were achieved (disappearance or only decrease of mastodynia) and no anti-proliferative effects were obtained. Basically, hormone treatment should be made based on a histopathological examination. [Mh] Termos MeSH primário: Antineoplásicos Hormonais/uso terapêutico Anticoncepcionais Orais Sintéticos/uso terapêutico Danazol/uso terapêutico Doença da Mama Fibrocística/tratamento farmacológico Antagonistas de Hormônios/uso terapêutico Tamoxifeno/uso terapêutico [Mh] Termos MeSH secundário: Bromocriptina/uso terapêutico Quimioterapia Combinada Feminino Doença da Mama Fibrocística/patologia Seguimentos Seres Humanos Linestrenol/uso terapêutico Dor/tratamento farmacológico Estudos Retrospectivos Medição de Risco Resultado do Tratamento [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antineoplastic Agents, Hormonal); 0 (Contraceptives, Oral, Synthetic); 0 (Hormone Antagonists); 094ZI81Y45 (Tamoxifen); 3A64E3G5ZO (Bromocriptine); N29QWW3BUO (Danazol); N2Z8ALG4U5 (Lynestrenol) [Em] Mês de entrada: 1610 [Cu] Atualização por classe: 161230 [Lr] Data última revisão: 161230 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160804 [St] Status: MEDLINE

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[PMID]: 27295907 [Au] Autor: Dobrosavljevic A; Rakic S; Nikoli B; Raznatovic SJ; Dikic SD; Milosevic Z; Jurisic A; Skrobic M [Ti] Título: Diagnostic value of breast ultrasound in mammography BI-RADS 0 and clinically indeterminate or suspicious of malignancy breast lesions. [So] Source: Vojnosanit Pregl;73(3):239-45, 2016 Mar. [Is] ISSN: 0042-8450 [Cp] País de publicação: Serbia [La] Idioma: eng [Ab] Resumo: BACKGROUND/AIM: Not only that ultrasound makes the difference between cystic and solid changes in breast tissue, as it was the case at the beginning of its use, but it also makes the differential diagnosis in terms of benign-malignant. The aim of this study was to assess the role of sonography in the diagnosis of palpable breast masses according to the American College of Radiology Ultrasonographic Breast Imaging Reporting and Data System (BI-RADS) and to correlate the BI-RADS 4 and BI-RADS 5 category with pathohistological findings. METHODS: A retrospective study was conducted with the breast sonograms of 30 women presented with palpable breast masses found to be mammography category BI-RADS 0 and ultrasonographic BI-RADS categories 4 and 5. The sonographic categories were correlated with pathohistological findings. RESULTS: Surgical biopsy in 30 masses revealed: malignancy (56.7%), fibroadenoma (26.7%), fibrocystic dysplasia with/without atypia (10/6), lipoma (3.3%) and intramammary lymph node (3.3%). Correlation between BI-RADS categories and pathohistological findings was found (P < 0.05). All BI-RADS 5 masses were malignant, while in BI-RADS 4A category fibroadenomas dominated. A total of 53.8% of all benign lesions were found in women 49 years of age or younger as compared with 35.3% of all malignancies in this group (p < 0.05). CONCLUSION: Ultrasonography BI-RADS improved classification of breast masses. The ultrasound BI-RADS 4 (A, B, C) and BI-RADS 5 lesions should be worked-up with biopsy. [Mh] Termos MeSH primário: Neoplasias da Mama/diagnóstico por imagem Carcinoma Ductal de Mama/diagnóstico por imagem Carcinoma Intraductal não Infiltrante/diagnóstico por imagem Carcinoma Lobular/diagnóstico por imagem Fibroadenoma/diagnóstico por imagem Doença da Mama Fibrocística/diagnóstico por imagem Lipoma/diagnóstico por imagem Linfonodos/diagnóstico por imagem [Mh] Termos MeSH secundário: Adulto Idoso Biópsia Neoplasias da Mama/patologia Carcinoma Ductal de Mama/patologia Carcinoma Intraductal não Infiltrante/patologia Carcinoma Lobular/patologia Estudos de Coortes Diagnóstico Diferencial Feminino Fibroadenoma/patologia Doença da Mama Fibrocística/patologia Seres Humanos Lipoma/patologia Linfonodos/patologia Meia-Idade Estudos Retrospectivos Ultrassonografia Mamária [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1607 [Cu] Atualização por classe: 161126 [Lr] Data última revisão: 161126 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160615 [St] Status: MEDLINE

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1			PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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