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Pesquisa : C17.800.135 [Categoria DeCS]
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  1 / 2411 MEDLINE  
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[PMID]:29480882
[Au] Autor:Yang JH; Shin JY; Roh SG; Chang SC; Lee NH
[Ad] Endereço:Department of Plastic and Reconstructive Surgery, Medical School of Chonbuk National University.
[Ti] Título:Delayed diagnosis of xanthogranulomatous pyelonephritis in a quadriplegic patient with uncontrolled cutaneous fistula: A case report.
[So] Source:Medicine (Baltimore);97(2):e9659, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Xanthogranulomatous pyelonephritis (XGP) is a chronic destructive granulomatous inflammation that is characterized by urinary tract obstruction and invasion of the renal parenchyma. Although rare, XGP can lead to fatal complications, including perinephric inflammation, psoas abscess, and cutaneous fistula. PATIENT CONCERNS: A quadriplegic patient initially presented to the hospital with a chronic open wound and cutaneous fistula. DIAGNOSES: Abdominal computed tomography revealed a renal obstructing stone and enlarged right kidney with a perinephric fluid collection that communicated with the cutaneous fistula. INTERVENTIONS: The patient underwent a right nephrectomy at the department of urology. OUTCOMES: Two months after surgery, the patient was clinically well with no discharging fistula. LESSONS: The XGP accompanied by complications requires an immediate evaluation and early diagnosis. In this case, the diagnosis was delayed because the state of quadriplegia rendered no symptoms of XGP.
[Mh] Termos MeSH primário: Fístula Cutânea/complicações
Pielonefrite Xantogranulomatosa/complicações
Pielonefrite Xantogranulomatosa/diagnóstico
Quadriplegia/complicações
[Mh] Termos MeSH secundário: Fístula Cutânea/diagnóstico
Diagnóstico Tardio
Seres Humanos
Rim/diagnóstico por imagem
Rim/cirurgia
Masculino
Meia-Idade
Nefrectomia
Pielonefrite Xantogranulomatosa/cirurgia
Quadriplegia/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009659


  2 / 2411 MEDLINE  
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[PMID]:29332920
[Au] Autor:Zhao C; Zhu Z; Zheng X; Liu K
[Ad] Endereço:Department of Cardiovascular Surgery, 2nd Hospital of Bethune, Jilin University, Changchun.
[Ti] Título:Aorto-Cutaneous Fistula after Surgical Treatment of Stanford Type A Aortic Dissection.
[So] Source:Int Heart J;59(1):223-225, 2018 Jan 27.
[Is] ISSN:1349-3299
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:An aorto-cutaneous fistula is a rare complication that occurs after aortic surgery. Due to its rarity, postoperative complications are not normally highlighted in most standard teaching. We report here a case of aorto-cutaneous fistula after surgical treatment of a Stanford type A aortic dissection (AD) in a 67-year-old Chinese male. The patient presented with severe right heart dysfunction and a mass was found in the upper-middle of his chest, which started bleeding in the next years. On admission, preoperative aortic computed tomography angiography (CTA) showed a huge hematoma located in the anterior superior mediastinum and a shunt between the embedding cavity of the aortic root and right atrium. An emergent procedure was performed. Intraoperatively, we found two leaks approximately 2 mm from the anastomosis of the greater curvature of the ascending aortic graft and stented graft after the hematoma was cleared and we confirmed the shunt had a large amount of blood flow after a right atrium incision. After the surgery, the patient was diagnosed with a cerebral hemorrhage, and his family decided to refuse therapy on the third postoperative day (p.o.d.).
[Mh] Termos MeSH primário: Aneurisma Dissecante/cirurgia
Aneurisma da Aorta Torácica/cirurgia
Implante de Prótese Vascular/efeitos adversos
Fístula Cutânea/etiologia
Complicações Pós-Operatórias
Stents/efeitos adversos
Fístula Vascular/etiologia
[Mh] Termos MeSH secundário: Idoso
Aneurisma Dissecante/diagnóstico
Aneurisma da Aorta Torácica/diagnóstico
Angiografia por Tomografia Computadorizada
Fístula Cutânea/diagnóstico
Fístula Cutânea/cirurgia
Ecocardiografia Doppler em Cores
Seres Humanos
Masculino
Reoperação
Fístula Vascular/diagnóstico
Fístula Vascular/cirurgia
Procedimentos Cirúrgicos Vasculares/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180116
[St] Status:MEDLINE
[do] DOI:10.1536/ihj.17-109


  3 / 2411 MEDLINE  
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[PMID]:28468220
[Au] Autor:Lam K; Ho T; Yao WC
[Ad] Endereço:*Department of Otolaryngology, Head and Neck Surgery, Eastern Virginia Medical School, Norfolk, VA †Department of Otorhinolaryngology, Head and Neck Surgery, University of Texas McGovern Medical School, Houston, TX.
[Ti] Título:Sinocutaneous Fistula Formation After Forehead Recontouring Surgery for Transgender Patients.
[So] Source:J Craniofac Surg;28(3):e274-e277, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Forehead recontouring is a common part of facial feminization surgery. The procedure, which alters the shape and structure of the frontal bone, is regarded as safe and well tolerated by patients. The occurrence of delayed complications, however, is much less understood. The authors describe a patient involving the development of a sinocutaneous fistula as a delayed complication of forehead recontouring surgery. The clinical presentation and management of this patient are discussed. As facial feminization surgery expands as a cosmetic option for patients who desire more feminine facial features, practitioners should recognize the potential risk of sinonasal complications associated with forehead recontouring surgery.
[Mh] Termos MeSH primário: Fístula Cutânea/etiologia
Feminização
Testa/cirurgia
Doenças dos Seios Paranasais/etiologia
Complicações Pós-Operatórias
Ritidoplastia/efeitos adversos
Pessoas Transgênero
[Mh] Termos MeSH secundário: Idoso
Fístula Cutânea/diagnóstico
Endoscopia
Feminino
Fístula/diagnóstico
Fístula/etiologia
Seio Frontal
Seres Humanos
Masculino
Doenças dos Seios Paranasais/diagnóstico
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003524


  4 / 2411 MEDLINE  
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[PMID]:29049168
[Au] Autor:van der Woerd BD; MacNeil SD
[Ad] Endereço:Department of Otolaryngology-Head and Neck Surgery, Western University, London, ON, Canada.
[Ti] Título:Sialocutaneous fistula to the external auditory canal repaired with superficial parotidectomy and temporoparietal flap: A case report.
[So] Source:Medicine (Baltimore);96(42):e7038, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Gustatory otorrhea can lead to cutaneous changes, recurrent infection, and social disruption. We present a case of a late, evolving sialocutaneous fistula to the external auditory canal, managed surgically after failing conservative therapies. This case is unique by late evolution, whereby the symptoms presented with significance 27 years after her operation and 19 years after mild symptoms initially arose. PATIENT CONCERNS: Gustatory, left-sided clear otorrhea with acutely increased volume over 8 months causing social disruption. DIAGNOSES: Sialocutaneous fistula to the external auditory canal. INTERVENTIONS: Superficial parotidectomy and temporoparietal flap for closure of fistula. OUTCOMES: No postoperative complications and resolution of gustatory otorrhea at one-year follow-up. LESSONS: This rare, but important, postoperative complication can present late with evolving symptoms, causing significant social disruption. It can be treated with conservative medical management and several surgical approaches.
[Mh] Termos MeSH primário: Fístula Cutânea/cirurgia
Meato Acústico Externo
Glândula Parótida/cirurgia
Procedimentos Cirúrgicos Reconstrutivos/métodos
Fístula das Glândulas Salivares/cirurgia
Retalhos Cirúrgicos
[Mh] Termos MeSH secundário: Adulto
Fístula Cutânea/etiologia
Fáscia/transplante
Fasciotomia/métodos
Feminino
Seres Humanos
Transtornos de Início Tardio/etiologia
Transtornos de Início Tardio/cirurgia
Fístula das Glândulas Salivares/etiologia
Sudorese Gustativa/complicações
Músculo Temporal/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007038


  5 / 2411 MEDLINE  
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[PMID]:28792850
[Au] Autor:Akashi M; Kusumoto J; Sakakibara A; Hashikawa K; Furudoi S; Komori T
[Ad] Endereço:1 Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine , Kobe, Japan .
[Ti] Título:Literature Review of Criteria for Defining Recipient-Site Infection after Oral Oncologic Surgery with Simultaneous Reconstruction.
[So] Source:Surg Infect (Larchmt);18(7):755-764, 2017 Oct.
[Is] ISSN:1557-8674
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The lack of uniformity of criteria for defining recipient-site infection after oral oncologic surgery with simultaneous reconstruction is problematic despite numerous studies on this issue. This study aimed to investigate the difference in the criteria for defining recipient-site infection after oral oncologic surgery with reconstruction. METHODS: A Medline search was performed via PUBMED using the following combinations of key terms that were tagged in the title, abstract, or both: "surgical site infection-head neck," "surgical site infection-oral cancer," "antibiotic prophylaxis-head neck," and "surgical site infection-oral carcinoma." Search results were filtered between 2005 and 2017. Articles in which there was no mention of the criteria for definition of surgical-site infection were excluded. RESULTS: The number of articles that met the inclusion criteria was 24. The lack of uniformity in the criteria for defining recipient-site infection in each article appeared to be attributable mainly to differences in whether an orocutaneous fistula and superficial incisional infection were regarded as recipient-site infection. CONCLUSION: Reconsideration of the categorization of orocutaneous fistula as infection, regardless of the etiology, and differentiation of superficial and deep incisional infections are necessary for correct assessment of recipient-site infection in oral oncologic surgery.
[Mh] Termos MeSH primário: Neoplasias Bucais/cirurgia
Procedimentos Cirúrgicos Reconstrutivos/efeitos adversos
Retalhos Cirúrgicos/efeitos adversos
Infecção da Ferida Cirúrgica
[Mh] Termos MeSH secundário: Antibioticoprofilaxia
Fístula Cutânea
Seres Humanos
Infecção da Ferida Cirúrgica/diagnóstico
Infecção da Ferida Cirúrgica/tratamento farmacológico
Infecção da Ferida Cirúrgica/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1089/sur.2017.101


  6 / 2411 MEDLINE  
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[PMID]:28594722
[Au] Autor:Nordholm-Carstensen A; Krarup PM; Hagen K
[Ad] Endereço:Digestive Disease Center, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
[Ti] Título:Treatment of Complex Fistula-in-Ano With a Nitinol Proctology Clip.
[So] Source:Dis Colon Rectum;60(7):723-728, 2017 Jul.
[Is] ISSN:1530-0358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The treatment of complex anocutaneous fistulas remains a major therapeutic challenge balancing the risk of incontinence against the chance of permanent closure. OBJECTIVE: The purpose of this study was to investigate the efficacy of a nitinol proctology clip for closure of complex anocutaneous fistulas. DESIGN: This is a single-center cohort study with retrospective analysis of all of the treated patients. SETTINGS: Data were obtained from patient records and MRI reports, as well as follow-up telephone calls and clinical follow-up with endoanal ultrasonography. PATIENTS: All of the patients were treated for high transsphincteric and suprasphincteric anocutaneous fistulas at the Digestive Disease Center, Bispebjerg Hospital, between May 2013 and February 2015. INTERVENTIONS: All of the patients were treated with the nitinol proctology clip. MAIN OUTCOME MEASURES: Primary outcome was fistula healing after proctology clip placement, as evaluated through clinical examination, endoanal ultrasonography, and MRI. RESULTS: The fistula healing rate 1 year after the clip procedure was 54.3% (19 of 35 included patients). At the end of follow-up, 17 (49%) of 35 patients had persistent closure of the fistula tracks. No impairment of continence function was observed. Treatment outcome was not found to be statistically associated with any clinicopathological characteristics. LIMITATIONS: The study is limited by its retrospective and nonrandomized design. Selection bias may have occurred, because treatment options other than the clip were available during the study period. The small number of patients means that there is a nonnegligible risk of type II error in the conclusion, and the follow-up may be too short to have detected all of the failures. CONCLUSIONS: Healing rates were comparable with those of other noninvasive, sphincter-sparing techniques for high-complex anocutaneous fistulas, with no risk of incontinence. Predictive parameters for fistula healing using this technique remain uncertain. See Video Abstract at http://links.lww.com/DCR/A347.
[Mh] Termos MeSH primário: Fístula Cutânea/cirurgia
Fístula Retal/cirurgia
Instrumentos Cirúrgicos
[Mh] Termos MeSH secundário: Adulto
Ligas
Estudos de Coortes
Doença de Crohn/complicações
Fístula Cutânea/etiologia
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Duração da Cirurgia
Fístula Retal/etiologia
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Nm] Nome de substância:
0 (Alloys); 2EWL73IJ7F (nitinol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.1097/DCR.0000000000000831


  7 / 2411 MEDLINE  
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[PMID]:28520896
[Au] Autor:Partington EJ; Moore LS; Kahmke R; Warram JM; Carroll W; Rosenthal EL; Greene BJ
[Ad] Endereço:Department of Otolaryngology, University of Alabama at Birmingham, Birmingham.
[Ti] Título:Laser-Assisted Indocyanine Green Dye Angiography for Postoperative Fistulas After Salvage Laryngectomy.
[So] Source:JAMA Otolaryngol Head Neck Surg;143(8):775-781, 2017 Aug 01.
[Is] ISSN:2168-619X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Pharyngocutaneous fistula formation is an unfortunate complication after salvage laryngectomy for head and neck cancer that is difficult to anticipate and related to a variety of factors, including the viability of native pharyngeal mucosa. Objective: To examine whether noninvasive angiography with indocyanine green (ICG) dye can be used to evaluate native pharyngeal vascularity to anticipate pharyngocutaneous fistula development. Design, Setting, and Participants: This cohort study included 37 patients enrolled from June 1, 2013, to June 1, 2016, and follow-up was for at least 1 month postoperatively. The study was performed at the University of Alabama at Birmingham, a tertiary care center. Included patients were those undergoing salvage total laryngectomy who were previously treated with chemoradiotherapy or radiotherapy alone. Exposures: The ICG dye was injected intraoperatively, and laser-assisted vascular imaging was used to evaluate the native pharyngeal mucosa after the ablative procedure. The center of the native pharyngeal mucosa was used as the reference to compare with the peripheral mucosa, and the lowest mean ICG dye percentage of mucosal perfusion was recorded for each patient. Main Outcomes and Measures: The primary outcome was the formation of a postoperative fistula, which was assessed by clinical and radiographic assessment to test the hypothesis formulated before data collection. Results: A total of 37 patients were included (mean [SD] age, 62.3 [8.5] years; 32 [87%] male and 5 [14%] female); 20 had a history of chemoradiotherapy, and 17 had history of radiotherapy alone. Thirty-four patients (92%) had free flap reconstruction, and 3 had primary closure (8%). Ten patients (27%) developed a postoperative fistula. No significant difference was found in fistula rate between patients who underwent neck dissection and those who did not and patients previously treated with chemoradiotherapy and those treated with radiotherapy alone. A receiver operator characteristic curve was generated to determine the diagnostic performance of the lowest mean ICG dye percentage of mucosal perfusion determined by fluorescence imaging, which was found to be a threshold value of 26%. The area under the curve was 0.85 (95% CI, 0.73-0.97), which was significantly greater than the chance diagonal. The overall mean lowest ICG dye percentage of mucosal perfusion was 31.3%. The mean lowest ICG dye percentage of mucosal perfusion was 22.0% in the fistula group vs 34.9% in the nonfistula group (absolute difference, 12.9%; 95% CI, 5.1%-21.7%). Conclusions and Relevance: Patients who developed postoperative fistulas had lower mucosal perfusion as detected by ICG dye angiography when compared with patients who did not develop fistulas.
[Mh] Termos MeSH primário: Angiografia/métodos
Fístula Cutânea/diagnóstico por imagem
Neoplasias de Cabeça e Pescoço/cirurgia
Doenças Faríngeas/diagnóstico por imagem
Faringe/irrigação sanguínea
Complicações Pós-Operatórias/diagnóstico por imagem
[Mh] Termos MeSH secundário: Alabama
Feminino
Seres Humanos
Verde de Indocianina
Laringectomia/métodos
Lasers
Masculino
Meia-Idade
Terapia de Salvação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
IX6J1063HV (Indocyanine Green)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE
[do] DOI:10.1001/jamaoto.2017.0187


  8 / 2411 MEDLINE  
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[PMID]:28476833
[Au] Autor:Bacalbasa N; Stoica C; Balescu I
[Ad] Endereço:Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania nicolae_bacalbasa@yahoo.ro.
[Ti] Título:Multiple Visceral Resections for Synchronous Left and Transverse Colon Adenocarcinoma with Gastrocolic-cutaneous Fistula - Case Report and Literature Review.
[So] Source:Anticancer Res;37(5):2601-2607, 2017 05.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Synchronous adenocarcinomas of the colon represent a rare situation, characterized by the presence of at least two colonic malignancies separated by at least 4-cm distance, in the absence of submucosal spread. Gastrocolic-cutaneous fistulas also represent a rare complication associated with the presence of colonic or gastric adenocarcinomas. We present the case of a 61-year-old patient who presented for abdominal pain, vomiting, weight loss and cutaneous exteriorization of purulent liquid. Intraoperatively, a large centro-abdominal tumor with gastroduodenal, pancreatic and colonic invasion was found in association with a synchronous left colonic tumor. The tumors were resected en bloc with distal gastrectomy, cephalic pancreatoduodenectomy, segmental enterectomy, subtotal colectomy and upper abdominal lymph node dissection. The histopathological studies revealed the presence of two synchronous colonic tumors: one located on the transverse colon, with pancreatic, duodeno-jejunal and gastric invasion and gastrocolic-cutaneous fistula, and a second one located on the left colon. Both tumors proved to be moderately differentiated colonic adenocarcinomas. At 1-year follow-up the patient remains free of any recurrent disease.
[Mh] Termos MeSH primário: Adenocarcinoma/diagnóstico
Neoplasias do Colo/diagnóstico
Fístula Cutânea/diagnóstico
Fístula Gástrica/diagnóstico
[Mh] Termos MeSH secundário: Adenocarcinoma/patologia
Adenocarcinoma/cirurgia
Colo Transverso/patologia
Colo Transverso/cirurgia
Neoplasias do Colo/patologia
Neoplasias do Colo/cirurgia
Fístula Cutânea/patologia
Fístula Cutânea/cirurgia
Fístula Gástrica/patologia
Fístula Gástrica/cirurgia
Seres Humanos
Metástase Linfática
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE


  9 / 2411 MEDLINE  
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[PMID]:28400394
[Au] Autor:Aeron R; Goel A; Sokhal AK; Goel S
[Ad] Endereço:Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh, India.
[Ti] Título:Urethrocutaneous fistula mimicking vesicocutaneous fistula: a rare entity.
[So] Source:BMJ Case Rep;2017, 2017 Apr 11.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Urethral fistulas arising from the anterior urethra usually open on the ventral aspect and are located in the penile, scrotal or perineal region. A diabetic 65-year-old man presented with suprapubic urinary fistula that was communicating with a dorsally located internal urethral opening located in the bulbar region. Such unusual fistula has not been described before.
[Mh] Termos MeSH primário: Fístula Cutânea/cirurgia
Doenças Uretrais/cirurgia
Fístula Urinária/cirurgia
[Mh] Termos MeSH secundário: Fístula Cutânea/diagnóstico
Seres Humanos
Masculino
Meia-Idade
Doenças Uretrais/diagnóstico
Fístula Urinária/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE


  10 / 2411 MEDLINE  
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[PMID]:28400193
[Au] Autor:Dietz AB; Dozois EJ; Fletcher JG; Butler GW; Radel D; Lightner AL; Dave M; Friton J; Nair A; Camilleri ET; Dudakovic A; van Wijnen AJ; Faubion WA
[Ad] Endereço:Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota. Electronic address: dietz.allan@mayo.edu.
[Ti] Título:Autologous Mesenchymal Stem Cells, Applied in a Bioabsorbable Matrix, for Treatment of Perianal Fistulas in Patients With Crohn's Disease.
[So] Source:Gastroenterology;153(1):59-62.e2, 2017 Jul.
[Is] ISSN:1528-0012
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In patients with Crohn's disease, perianal fistulas recur frequently, causing substantial morbidity. We performed a 12-patient, 6-month, phase 1 trial to determine whether autologous mesenchymal stem cells, applied in a bioabsorbable matrix, can heal the fistula. Fistula repair was not associated with any serious adverse events related to mesenchymal stem cells or plug placement. At 6 months, 10 of 12 patients (83%) had complete clinical healing and radiographic markers of response. We found placement of mesenchymal stem cell-coated matrix fistula plugs in 12 patients with chronic perianal fistulas to be safe and lead to clinical healing and radiographic response in 10 patients. ClinicalTrials.gov Identifier: NCT01915927.
[Mh] Termos MeSH primário: Doença de Crohn/complicações
Fístula Cutânea/terapia
Transplante de Células-Tronco Mesenquimais
Fístula Retal/terapia
[Mh] Termos MeSH secundário: Implantes Absorvíveis/efeitos adversos
Adolescente
Adulto
Fístula Cutânea/etiologia
Feminino
Seres Humanos
Masculino
Transplante de Células-Tronco Mesenquimais/efeitos adversos
Meia-Idade
Fístula Retal/etiologia
Transplante Autólogo
Resultado do Tratamento
Cicatrização
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE I; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE



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