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[PMID]:28393697
[Au] Autor:Angiolella L; Carradori S; Maccallini C; Giusiano G; Supuran CT
[Ad] Endereço:Department of Public Health and Infectious Diseases, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
[Ti] Título:Targeting Malassezia species for Novel Synthetic and Natural Antidandruff Agents.
[So] Source:Curr Med Chem;24(22):2392-2412, 2017.
[Is] ISSN:1875-533X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Malassezia spp. are lipophilic yeasts not only present in the normal skin microflora, but also responsible of skin-related diseases (pityriasis versicolor, seborrheic/atopic dermatitis and dandruff) as well as systemic fungal infections in humans and animals. Their treatment and eradication are mainly based on old azole drugs, which are characterized by poor compliance, unpredictable clinical efficacy, emerging resistance and several side effects. These drawbacks have prompted the research toward novel synthetic and natural derivatives/ nanomaterials targeting other pivotal enzymes/pathways such as carbonic anhydrase (MgCA) and lipases, alone or in combination, in order to improve the eradication rate of this fungus. This review accomplished an update on this important topic dealing with the latest discoveries of synthetic scaffolds and natural products for the treatment of Malassezia spp.-related diseases, thus suggesting new opportunities to design innovative and alternative anti-dandruff drugs.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Produtos Biológicos/farmacologia
Caspa/tratamento farmacológico
Caspa/microbiologia
Inibidores Enzimáticos/farmacologia
Malassezia/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antifúngicos/síntese química
Antifúngicos/química
Produtos Biológicos/síntese química
Produtos Biológicos/química
Anidrases Carbônicas/metabolismo
Inibidores Enzimáticos/síntese química
Inibidores Enzimáticos/química
Lipase/antagonistas & inibidores
Lipase/metabolismo
Testes de Sensibilidade Microbiana
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Biological Products); 0 (Enzyme Inhibitors); EC 3.1.1.3 (Lipase); EC 4.2.1.1 (Carbonic Anhydrases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE
[do] DOI:10.2174/0929867324666170404110631


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[PMID]:28086217
[Au] Autor:Zhao C; Chen X; Yang C; Zang D; Lan X; Liao S; Zhang P; Wu J; Li X; Liu N; Liao Y; Huang H; Shi X; Jiang L; Liu X; Dou QP; Wang X; Liu J
[Ad] Endereço:State Key Laboratory of Respiratory Disease, Protein Modification and Degradation Laboratory, Department of Pathophysiology, Guangzhou Medical University, Guangdong 510182, China.
[Ti] Título:Repurposing an antidandruff agent to treating cancer: zinc pyrithione inhibits tumor growth via targeting proteasome-associated deubiquitinases.
[So] Source:Oncotarget;8(8):13942-13956, 2017 Feb 21.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The ubiquitin-proteasome system (UPS) plays a central role in various cellular processes through selectively degrading proteins involved in critical cellular functions. Targeting UPS has been validated as a novel strategy for treating human cancer, as inhibitors of the 20S proteasome catalytic activity are currently in clinical use for treatment of multiple myeloma and other cancers, and the deubiquitinase activity associated with the proteasome is also a valid target for anticancer agents. Recent studies suggested that zinc pyrithione, an FDA-approved antidandruff agent, may have antitumor activity, but the detailed molecular mechanisms remain unclear. Here we report that zinc pyrithione (ZnPT) targets the proteasome-associated DUBs (USP14 and UCHL5) and inhibits their activities, resulting in a rapid accumulation of protein-ubiquitin conjugates, but without inhibiting the proteolytic activities of 20S proteasomes. Furthermore, ZnPT exhibits cytotoxic effects against various cancer cell lines in vitro, selectively kills bone marrow cells from leukemia patients ex vivo, and efficiently inhibits the growth of lung adenocarcinoma cancer cell xenografts in nude mice. This study has identified zinc pyrithione, an FDA-approved pharmacological agent with potential antitumor properties as a proteasomal DUB inhibitor.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Ceratolíticos/farmacologia
Neoplasias Experimentais/patologia
Compostos Organometálicos/farmacologia
Complexo de Endopeptidases do Proteassoma/efeitos dos fármacos
Piridinas/farmacologia
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Western Blotting
Linhagem Celular Tumoral
Caspa/tratamento farmacológico
Imunofluorescência
Seres Humanos
Imuno-Histoquímica
Camundongos
Camundongos Nus
Modelos Moleculares
Inibidores de Proteassoma/farmacologia
Ubiquitina Tiolesterase/efeitos dos fármacos
Ubiquitina Tiolesterase/metabolismo
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Keratolytic Agents); 0 (Organometallic Compounds); 0 (Proteasome Inhibitors); 0 (Pyridines); EC 3.1.2.15 (USP14 protein, human); EC 3.4.19.12 (UCHL5 protein, human); EC 3.4.19.12 (Ubiquitin Thiolesterase); EC 3.4.25.1 (Proteasome Endopeptidase Complex); R953O2RHZ5 (pyrithione zinc)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170114
[St] Status:MEDLINE
[do] DOI:10.18632/oncotarget.14572


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[PMID]:27882618
[Au] Autor:Park M; Cho YJ; Lee YW; Jung WH
[Ad] Endereço:Department of Systems Biotechnology, Chung-Ang University, Anseong, Korea.
[Ti] Título:Whole genome sequencing analysis of the cutaneous pathogenic yeast Malassezia restricta and identification of the major lipase expressed on the scalp of patients with dandruff.
[So] Source:Mycoses;60(3):188-197, 2017 Mar.
[Is] ISSN:1439-0507
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Malassezia species are opportunistic pathogenic fungi that are frequently associated with seborrhoeic dermatitis, including dandruff. Most Malassezia species are lipid dependent, a property that is compensated by breaking down host sebum into fatty acids by lipases. In this study, we aimed to sequence and analyse the whole genome of Malassezia restricta KCTC 27527, a clinical isolate from a Korean patient with severe dandruff, to search for lipase orthologues and identify the lipase that is the most frequently expressed on the scalp of patients with dandruff. The genome of M. restricta KCTC 27527 was sequenced using the Illumina MiSeq and PacBio platforms. Lipase orthologues were identified by comparison with known lipase genes in the genomes of Malassezia globosa and Malassezia sympodialis. The expression of the identified lipase genes was directly evaluated in swab samples from the scalps of 56 patients with dandruff. We found that, among the identified lipase-encoding genes, the gene encoding lipase homolog MRES_03670, named LIP5 in this study, was the most frequently expressed lipase in the swab samples. Our study provides an overview of the genome of a clinical isolate of M. restricta and fundamental information for elucidating the role of lipases during fungus-host interaction.
[Mh] Termos MeSH primário: Caspa/microbiologia
Genoma Fúngico
Lipase/genética
Malassezia/enzimologia
Malassezia/genética
Couro Cabeludo
[Mh] Termos MeSH secundário: Dermatite Seborreica/microbiologia
Expressão Gênica
Sequenciamento de Nucleotídeos em Larga Escala
Interações Hospedeiro-Patógeno
Seres Humanos
Lipase/isolamento & purificação
Malassezia/isolamento & purificação
Malassezia/patogenicidade
Filogenia
Couro Cabeludo/microbiologia
Alinhamento de Sequência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.1.1.3 (Lipase)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170323
[Lr] Data última revisão:
170323
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161125
[St] Status:MEDLINE
[do] DOI:10.1111/myc.12586


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[PMID]:27497434
[Au] Autor:Honnavar P; Chakrabarti A; Prasad GS; Singh P; Dogra S; Rudramurthy SM
[Ad] Endereço:Mycology Division, Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
[Ti] Título:ß-Endorphin enhances the phospholipase activity of the dandruff causing fungi Malassezia globosa and Malassezia restricta.
[So] Source:Med Mycol;55(2):150-154, 2017 Feb 01.
[Is] ISSN:1460-2709
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:ß-Endorphin is known to stimulate phospholipase production by Malassezia pachydermatis during canine dermatoses. The role of ß-endorphin in Malassezia infection in humans is not well studied. The present study compares the influence of ß-endorphin on Malassezia globosa and Malassezia restricta isolated from patients with seborrhoeic dermatitis/dandruff (SD/D) and healthy controls. Malassezia isolates (five each of the two species from patients and healthy controls) were grown on modified Dixon's agar with or without 100 nmol/L ß-endorphin. Phospholipase activity was quantified based on its ability to hydrolyze L-α-phosphatidylcholine dimyristoyl (phospholipid substrate). Free fatty acid was measured by a colorimetry method. In isolates from patients, the phospholipase activity significantly increased after exposure to ß-endorphin (M. globosa, P = .04; M. restricta, P = .001), which did not occur in isolates from healthy controls. Moreover, after ß-endorphin exposure the patient isolates had significantly higher (P = .0004) phospholipase activity compared to the healthy control isolates. The results suggest that isolates of M. globosa and M. restricta from patients may differ from those of healthy humans.
[Mh] Termos MeSH primário: Caspa/microbiologia
Voluntários Saudáveis
Malassezia/efeitos dos fármacos
Malassezia/enzimologia
Fosfolipases/análise
beta-Endorfina/metabolismo
[Mh] Termos MeSH secundário: Colorimetria
Meios de Cultura/química
Ácidos Graxos/análise
Seres Humanos
Malassezia/crescimento & desenvolvimento
Malassezia/isolamento & purificação
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Culture Media); 0 (Fatty Acids); 60617-12-1 (beta-Endorphin); EC 3.1.- (Phospholipases)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160807
[St] Status:MEDLINE
[do] DOI:10.1093/mmy/myw058


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[PMID]:27909689
[Au] Autor:Soares RC; Camargo-Penna PH; de Moraes VC; De Vecchi R; Clavaud C; Breton L; Braz AS; Paulino LC
[Ad] Endereço:Centro de Ciências Naturais e Humanas, Universidade Federal do ABC Santo André, Brazil.
[Ti] Título:Dysbiotic Bacterial and Fungal Communities Not Restricted to Clinically Affected Skin Sites in Dandruff.
[So] Source:Front Cell Infect Microbiol;6:157, 2016.
[Is] ISSN:2235-2988
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Dandruff is a prevalent chronic inflammatory skin condition of the scalp that has been associated with yeasts. However, the microbial role has not been elucidated yet, and the etiology of the disorder remains poorly understood. Using high-throughput 16S rDNA and ITS1 sequencing, we characterized cutaneous bacterial and fungal microbiotas from healthy and dandruff subjects, comparing scalp and forehead (lesional and non-lesional skin sites). Bacterial and fungal communities from dandruff analyzed at genus level differed in comparison with healthy ones, presenting higher diversity and greater intragroup variation. The microbial shift was observed also in non-lesional sites from dandruff subjects, suggesting that dandruff is related to a systemic process that is not restricted to the site exhibiting clinical symptoms. In contrast, microbiota analyzed at species level did not differ according to health status. A 2-step OTU assignment using combined databases substantially increased fungal assigned sequences, and revealed the presence of highly prevalent uncharacterized organisms (>37% of the reads). Although clinical symptoms of dandruff manifest locally, microbial dysbiosis beyond clinically affected skin sites suggests that subjects undergo systemic alterations, which could be considered for redefining therapeutic approaches.
[Mh] Termos MeSH primário: Bactérias/classificação
Bactérias/isolamento & purificação
Caspa/microbiologia
Disbiose
Fungos/classificação
Fungos/isolamento & purificação
Pele/microbiologia
[Mh] Termos MeSH secundário: Bactérias/genética
Análise por Conglomerados
DNA Bacteriano/química
DNA Bacteriano/genética
DNA Fúngico/química
DNA Fúngico/genética
DNA Ribossômico/química
DNA Ribossômico/genética
DNA Espaçador Ribossômico/química
DNA Espaçador Ribossômico/genética
Fungos/genética
Metagenômica
Filogenia
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (DNA, Fungal); 0 (DNA, Ribosomal); 0 (DNA, Ribosomal Spacer); 0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE


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[PMID]:27541567
[Au] Autor:Sathishkumar P; Preethi J; Vijayan R; Mohd Yusoff AR; Ameen F; Suresh S; Balagurunathan R; Palvannan T
[Ad] Endereço:Centre for Environmental Sustainability and Water Security (IPASA), Research Institute for Sustainable Environment (RISE), Universiti Teknologi Malaysia, 81310, Skudai, Johor Bahru, Malaysia.
[Ti] Título:Anti-acne, anti-dandruff and anti-breast cancer efficacy of green synthesised silver nanoparticles using Coriandrum sativum leaf extract.
[So] Source:J Photochem Photobiol B;163:69-76, 2016 Oct.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In this present investigation, AgNPs were green synthesised using Coriandrum sativum leaf extract. The physicochemical properties of AgNPs were characterised using UV-visible spectrophotometer, field emission scanning microscopy/energy dispersive X-ray (FESEM/EDX), Fourier transformed infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and Brunauer-Emmett-Teller (BET) analysis. Further, in vitro anti-acne, anti-dandruff and anti-breast cancer efficacy of green synthesised AgNPs were assessed against Propionibacterium acnes MTCC 1951, Malassezia furfur MTCC 1374 and human breast adenocarcinoma (MCF-7) cell line, respectively. The flavonoids present in the plant extract were responsible for the AgNPs synthesis. The green synthesised nanoparticles size was found to be ≈37nm. The BET analysis result shows that the surface area of the synthesised AgNPs was found to be 33.72m(2)g(-1). The minimal inhibitory concentration (MIC) of AgNPs for acne causative agent P. acnes and dandruff causative agent M. furfur was found to be at 3.1 and 25µgmL(-1), respectively. The half maximal inhibitory concentration (IC50) value of the AgNPs for MCF-7 cells was calculated as 30.5µgmL(-1) and complete inhibition was observed at a concentration of 100µgmL(-1). Finally, our results proved that green synthesised AgNPs using C. sativum have great potential in biomedical applications such as anti-acne, anti-dandruff and anti-breast cancer treatment.
[Mh] Termos MeSH primário: Acne Vulgar/tratamento farmacológico
Neoplasias da Mama/patologia
Coriandrum/química
Caspa/tratamento farmacológico
Nanopartículas Metálicas/química
Folhas de Planta/química
Prata/química
[Mh] Termos MeSH secundário: Acne Vulgar/microbiologia
Antibacterianos/síntese química
Antibacterianos/química
Antibacterianos/farmacologia
Antibacterianos/uso terapêutico
Antineoplásicos/síntese química
Antineoplásicos/química
Antineoplásicos/farmacologia
Antineoplásicos/uso terapêutico
Técnicas de Química Sintética
Caspa/microbiologia
Química Verde
Seres Humanos
Células MCF-7
Malassezia/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Compostos Fitoquímicos/química
Propionibacterium acnes/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antineoplastic Agents); 0 (Phytochemicals); 3M4G523W1G (Silver)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160820
[St] Status:MEDLINE


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[PMID]:26885780
[Au] Autor:Schwartz JR
[Ti] Título:Zinc Pyrithione: A Topical Antimicrobial With Complex Pharmaceutics.
[So] Source:J Drugs Dermatol;15(2):140-4, 2016 Feb.
[Is] ISSN:1545-9616
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Zinc pyrithione (ZPT) is an active material that has been used for over 50 years to effectively treat dandruff and seborrheic dermatitis (D/SD). It has become the most common material for that purpose, its use has expanded to include other skin benefits such as skin hygiene. However, there is much about ZPT that is unappreciated. It is a rationally developed molecule that was modeled after the naturally occurring antimicrobial aspergillic acid. The molecular basis for its antifungal activity has been elucidated. The efficacy of ZPT originates from two attributes. First, it has a very broad antimicrobial spectrum of activity, including fungi, gram-positive and -negative bacteria. Second, the material has very low solubility, resulting in formulation and delivery as a particulate material, which has distinct performance advantages. The particles are deposited and retained on the target skin surfaces even when delivered from rinse-off products. These particles slowly release molecularly active material to interact with the surface fungal and bacteria cells to control their population, functioning as slow-release reservoirs to provide extended and persistent benefits. This particulate nature, though, results in complex pharmaceutics to realize the full efficacy benefits; it is common to see products with the same ZPT level having widely varying levels of clinical performance. Several product matrix-determined factors directly impact resultant benefits: ZPT must be retained on the skin surface achieving uniform spatial distribution laterally as well as within hair follicles (especially on scalp); ZPT must be maintained as a physically stable dispersion in product; ZPT must be maintained in a chemically active form as there are many chemical reactions that can occur that can harm ZPT bioactivity. The benefits achievable by employing ZPT require significant pharmaceutics expertise to realize the full benefits of this active material.
[Mh] Termos MeSH primário: Anti-Infecciosos/administração & dosagem
Anti-Infecciosos/química
Química Farmacêutica/métodos
Compostos Organometálicos/administração & dosagem
Compostos Organometálicos/química
Piridinas/administração & dosagem
Piridinas/química
[Mh] Termos MeSH secundário: Administração Tópica
Animais
Antifúngicos/administração & dosagem
Antifúngicos/química
Caspa/tratamento farmacológico
Dermatite Seborreica/tratamento farmacológico
Seres Humanos
Dermatoses do Couro Cabeludo/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antifungal Agents); 0 (Organometallic Compounds); 0 (Pyridines); R953O2RHZ5 (pyrithione zinc)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170111
[Lr] Data última revisão:
170111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160218
[St] Status:MEDLINE


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[PMID]:26856923
[Au] Autor:Vullo D; Del Prete S; Capasso C; Supuran CT
[Ad] Endereço:Università degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm. 188, Via della Lastruccia 3, I-50019 Sesto Fiorentino (Firenze), Italy.
[Ti] Título:Carbonic anhydrase activators: Activation of the ß-carbonic anhydrase from Malassezia globosa with amines and amino acids.
[So] Source:Bioorg Med Chem Lett;26(5):1381-5, 2016 Mar 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The ß-carbonic anhydrase (CA, EC 4.2.1.1) from the dandruff producing fungus Malassezia globosa, MgCA, was investigated for its activation with amines and amino acids. MgCA was weakly activated by amino acids such as L-/D-His, L-Phe, D-DOPA, D-Trp, L-/D-Tyr and by the amine serotonin (KAs of 12.5-29.3µM) but more effectively activated by d-Phe, l-DOPA, l-Trp, histamine, dopamine, pyridyl-alkylamines, and 4-(2-aminoethyl)-morpholine, with KAs of 5.82-10.9µM. The best activators were l-adrenaline and 1-(2-aminoethyl)piperazine, with activation constants of 0.72-0.81µM. This study may help a better understanding of the activation mechanisms of ß-CAs from pathogenic fungi as well as the design of tighter binding ligands for this enzyme which is a drug target for novel types of anti-dandruff agents.
[Mh] Termos MeSH primário: Aminas/farmacologia
Aminoácidos/farmacologia
Anidrases Carbônicas/metabolismo
Malassezia/enzimologia
[Mh] Termos MeSH secundário: Antifúngicos/farmacologia
Caspa/tratamento farmacológico
Caspa/microbiologia
Relação Dose-Resposta a Droga
Ligantes
Malassezia/efeitos dos fármacos
Estrutura Molecular
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amines); 0 (Amino Acids); 0 (Antifungal Agents); 0 (Ligands); EC 4.2.1.1 (Carbonic Anhydrases)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160210
[St] Status:MEDLINE


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[PMID]:26842231
[Au] Autor:Jourdain R; Moga A; Vingler P; El Rawadi C; Pouradier F; Souverain L; Bastien P; Amalric N; Breton L
[Ad] Endereço:L'OREAL Research and Innovation, Aulnay-sous-Bois, France. rjourdain@rd.loreal.com.
[Ti] Título:Exploration of scalp surface lipids reveals squalene peroxide as a potential actor in dandruff condition.
[So] Source:Arch Dermatol Res;308(3):153-63, 2016 Apr.
[Is] ISSN:1432-069X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Dandruff is a common but complex disorder with three major contributing factors: (1) individual predisposition, (2) scalp sebum and (3) Malassezia yeast colonization. To obtain further insights into the role of sebum in dandruff biogenesis, we analyzed scalp lipid species in a cohort of ten dandruff-free (control) and ten dandruff-afflicted volunteers by gas chromatography coupled to mass spectrometry. Lipid peroxidation levels and biochemical markers of oxidative stress were also assessed. Squalene, a major sebum component, was significantly more peroxidized in dandruff-affected scalps, resulting in significantly higher ratios of squalene monohydroperoxide (SQOOH)/squalene. This was observed when comparing dandruff-affected zones of dandruff subjects to both their non-affected zones and control subjects. In addition, other biomarkers such as malondialdehyde indicated that oxidative stress levels were raised on dandruff scalps. Surprisingly, differences regarding either free or bound fatty acids were fairly rare and minor. Certain novel findings, especially squalene peroxidation levels, were then confirmed in a validation cohort of 24 dandruff-affected subjects, by comparing dandruff-affected and non-dandruff zones from the same individuals. As SQOOH can induce both keratinocyte inflammatory responses and hyperproliferation in vitro, we hypothesized that increased SQOOH could be considered as a new etiological dandruff factor via its ability to impair scalp barrier function. Our results also indicated that Malassezia could be a major source of squalene peroxidation on the scalp.
[Mh] Termos MeSH primário: Caspa/metabolismo
Peroxidação de Lipídeos
Couro Cabeludo/metabolismo
Sebo/metabolismo
Esqualeno/análogos & derivados
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/análise
Biomarcadores/metabolismo
Estudos de Coortes
Caspa/etiologia
Caspa/microbiologia
Ácidos Graxos/análise
Ácidos Graxos/metabolismo
Feminino
Cromatografia Gasosa-Espectrometria de Massas
Voluntários Saudáveis
Seres Humanos
Queratinócitos/metabolismo
Malassezia/isolamento & purificação
Malassezia/metabolismo
Masculino
Malondialdeído/análise
Malondialdeído/metabolismo
Meia-Idade
Estresse Oxidativo
Couro Cabeludo/microbiologia
Sebo/química
Esqualeno/análise
Esqualeno/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (2,3-oxidosqualene); 0 (Biomarkers); 0 (Fatty Acids); 4Y8F71G49Q (Malondialdehyde); 7QWM220FJH (Squalene)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160205
[St] Status:MEDLINE
[do] DOI:10.1007/s00403-016-1623-1


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[PMID]:26792991
[Au] Autor:Anwar MF; Yadav D; Jain S; Kapoor S; Rastogi S; Arora I; Samim M
[Ad] Endereço:Department of Chemistry, Faculty of Science, Jamia Hamdard University, New Delhi, India.
[Ti] Título:Size- and shape-dependent clinical and mycological efficacy of silver nanoparticles on dandruff.
[So] Source:Int J Nanomedicine;11:147-61, 2016.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Dandruff is a prominent scalp problem caused by the growth of fungus Malassezia furfur, potentially cascading into dermal inflammation, itching, and tissue damage. The present work outlines a detailed analysis of the treatment of scalp infection using silver nanomaterials (Ag NMs), and focuses on biocidal activity owing to manipulation of size, shape, and structure. Monodisperse silver spherical nanoparticles (NPs) and nanorods (NRs) were synthesized by chemical routes that were characterized using analytical and spectroscopic techniques. Ag NMs demonstrated enhanced biocidal tendencies compared to market available drugs, itracanozole and ketoconazole, showing greater zones of inhibition. The obtained 20 nm and 50 nm spherical-shaped NPs and 50 nm NRs showed concentration-, size-, and shape-dependent antifungal activity, with 20 nm spherical-shaped NPs exhibiting excellent potency. Minimum inhibitory concentration for 20 nm was lowest at 0.2 mg/mL in comparison to 0.3 mg/mL for NRs. Primary irritation index was 0.33 and 0.16 for 20 nm and 50 nm spherical-shaped NPs, respectively, while 50 nm rod-shaped NMs exhibited negligible redness. An in vivo model for M. furfur infection was generated by passing fungi subcutaneously in rats' skin. Again, 20 nm particles showed best normalization of skin after 10 days on regular dosing, in comparison with bigger and rod-shaped particles. The statistical clinical score was highest for Ag nanorods, followed by 50 nm Ag NPs-treated animals. It was observed that 20 nm spherical particles exhibited the lowest score (0) compared with others as well as with antifungal drugs. Biochemical analysis performed by checking antioxidant enzymatic activities indicated tissue repair and normalization of enzymes and protein concentration by Ag NPs.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Caspa/tratamento farmacológico
Dermatomicoses/tratamento farmacológico
Malassezia/efeitos dos fármacos
Nanopartículas Metálicas/administração & dosagem
Nanoestruturas/administração & dosagem
Prata/química
[Mh] Termos MeSH secundário: Animais
Antifúngicos/química
Dermatomicoses/microbiologia
Masculino
Nanopartículas Metálicas/química
Nanoestruturas/química
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antifungal Agents); 3M4G523W1G (Silver)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160122
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S86828



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