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[PMID]:29390311
[Au] Autor:Suwarsa O; Rahardjo RM; Sutedja E; Dharmadji HP; Hindritiani R; Gunawan H
[Ad] Endereço:Division of Allergy and Immunology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin Hospital, Bandung, Indonesia.
[Ti] Título:Systemic contact dermatitis due to corrosion of titanium-coated nickel and cobalt bone plate fixation: A case report.
[So] Source:Medicine (Baltimore);96(50):e9120, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Corrosion refers to the degradation of a material that occurs following its interaction with other substances in the environment. Corrosion of metallic substances into tissues may lead to inflammatory responses such as systemic contact dermatitis (SCD), a skin condition where an individual who has previously been sensitized to a particular allergen via the cutaneous route will subsequently react to same allergen via the systemic route. This condition occurs following exposure to allergens such as metals, medications, and certain food substances. In recent years, the use of metal plates for internal fixation has become increasingly common in bone fracture repairs. PATIENT CONCERNS: A 34-year-old Indonesian male presented with systemic erythema with itching 7 days following a bone plate fixation as a management for mandibular fracture. DIAGNOSES: Physical examination showed pruritic red macules, papules, and scales on almost his entire body, along with facial swelling. The patch test results revealed a positive reaction to nickel and cobalt. Therefore, the patient was diagnosed with SCD. INTERVENTIONS: The patient was treated with topical and systemic corticosteroids as well as bone plate removal. OUTCOME: After treatment, the eruption turned brown, the itching was resolved, and there were no facial swelling as well. LESSONS: This case report highlights the need to consider the occurrence of SCD in patients following bone plate fixation.
[Mh] Termos MeSH primário: Placas Ósseas
Dermatite de Contato/etiologia
Dermatite de Contato/terapia
Fixação Interna de Fraturas/instrumentação
Fraturas Mandibulares/cirurgia
[Mh] Termos MeSH secundário: Corticosteroides/uso terapêutico
Adulto
Cobalto
Corrosão
Remoção de Dispositivo
Seres Humanos
Masculino
Níquel
Testes do Emplastro
Titânio
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 3G0H8C9362 (Cobalt); 7OV03QG267 (Nickel); D1JT611TNE (Titanium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009120


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[PMID]:28459556
[Au] Autor:Braga RC; Alves VM; Muratov EN; Strickland J; Kleinstreuer N; Trospsha A; Andrade CH
[Ad] Endereço:Laboratory for Molecular Modeling and Drug Design, Faculty of Pharmacy, Federal University of Goiás , Goiânia, GO 74605-170, Brazil.
[Ti] Título:Pred-Skin: A Fast and Reliable Web Application to Assess Skin Sensitization Effect of Chemicals.
[So] Source:J Chem Inf Model;57(5):1013-1017, 2017 05 22.
[Is] ISSN:1549-960X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chemically induced skin sensitization is a complex immunological disease with a profound impact on quality of life and working ability. Despite some progress in developing alternative methods for assessing the skin sensitization potential of chemical substances, there is no in vitro test that correlates well with human data. Computational QSAR models provide a rapid screening approach and contribute valuable information for the assessment of chemical toxicity. We describe the development of a freely accessible web-based and mobile application for the identification of potential skin sensitizers. The application is based on previously developed binary QSAR models of skin sensitization potential from human (109 compounds) and murine local lymph node assay (LLNA, 515 compounds) data with good external correct classification rate (0.70-0.81 and 0.72-0.84, respectively). We also included a multiclass skin sensitization potency model based on LLNA data (accuracy ranging between 0.73 and 0.76). When a user evaluates a compound in the web app, the outputs are (i) binary predictions of human and murine skin sensitization potential; (ii) multiclass prediction of murine skin sensitization; and (iii) probability maps illustrating the predicted contribution of chemical fragments. The app is the first tool available that incorporates quantitative structure-activity relationship (QSAR) models based on human data as well as multiclass models for LLNA. The Pred-Skin web app version 1.0 is freely available for the web, iOS, and Android (in development) at the LabMol web portal ( http://labmol.com.br/predskin/ ), in the Apple Store, and on Google Play, respectively. We will continuously update the app as new skin sensitization data and respective models become available.
[Mh] Termos MeSH primário: Alérgenos
Dermatite de Contato
Internet
Pele
Software
[Mh] Termos MeSH secundário: Alérgenos/toxicidade
Animais
Simulação por Computador
Bases de Dados de Compostos Químicos
Seres Humanos
Ensaio Local de Linfonodo
Camundongos
Relação Quantitativa Estrutura-Atividade
Pele/efeitos dos fármacos
Pele/patologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Allergens)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jcim.7b00194


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[PMID]:29198882
[Au] Autor:Sekiguchi K; Ogawa E; Kurohane K; Konishi H; Mochizuki N; Manabe K; Imai Y
[Ad] Endereço:Laboratory of Microbiology and Immunology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka City, Shizuoka 422-8526, Japan.
[Ti] Título:Adjuvant effect of short chain triacylglycerol tributyrin on a mouse contact hypersensitivity model.
[So] Source:Toxicol Lett;284:56-62, 2018 Mar 01.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Little attention has been paid to chemicals that can enhance hypersensitivity caused by other chemicals. We have demonstrated that phthalate esters with short chain alcohols enhance fluorescein isothiocyanate (FITC)-induced contact hypersensitivity (CHS) in a mouse model. Furthermore, phthalate esters with such an enhancing effect were found to activate transient receptor potential ankyrin 1 (TRPA1) cation channels, which are expressed on a part of sensory neurons, using a TRPA1-expressing cell line. In this study, we examined these activities of esters comprising glycerol and a short chain fatty acid, i.e. dibutyrin and tributyrin. We carried out chemical synthesis of dibutyrin isomers. Each dibutyrin isomer weakly activated TRPA1 and slightly enhanced skin sensitization to FITC. Unexpectedly, TRPA1 activation and enhancement of FITC-CHS were much more evident in the presence of tributyrin. Mechanistically, tributyrin induced increased dendritic cell trafficking from the skin to draining lymph nodes. Tributyrin enhanced interferon-γ (IFN-γ) production by draining lymph nodes, while its effect on interleukin-4 (IL-4) production was relatively less prominent. These results suggested that tributyrin concomitantly caused TRPA1 activation and an adjuvant effect on FITC-CHS.
[Mh] Termos MeSH primário: Adjuvantes Imunológicos/toxicidade
Dermatite de Contato/imunologia
Canal de Cátion TRPA1/metabolismo
Triglicerídeos/toxicidade
[Mh] Termos MeSH secundário: Adjuvantes Imunológicos/administração & dosagem
Animais
Células CHO
Movimento Celular/efeitos dos fármacos
Cricetulus
Células Dendríticas/efeitos dos fármacos
Dermatite de Contato/metabolismo
Modelos Animais de Doenças
Feminino
Fluoresceína-5-Isotiocianato/administração & dosagem
Fluoresceína-5-Isotiocianato/toxicidade
Seres Humanos
Interferon gama/metabolismo
Interleucina-4/metabolismo
Linfonodos/efeitos dos fármacos
Linfonodos/imunologia
Camundongos Endogâmicos BALB C
Pele/efeitos dos fármacos
Pele/imunologia
Triglicerídeos/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (TRPA1 Cation Channel); 0 (Triglycerides); 207137-56-2 (Interleukin-4); 82115-62-6 (Interferon-gamma); I223NX31W9 (Fluorescein-5-isothiocyanate); S05LZ624MF (tributyrin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


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[PMID]:29291408
[Au] Autor:Muro R; Nitta T; Kitajima M; Okada T; Suzuki H
[Ad] Endereço:Department of Immunology and Pathology, Research Institute, National Center for Global Health and Medicine, Chiba 272-8516, Japan.
[Ti] Título:Rasal3-mediated T cell survival is essential for inflammatory responses.
[So] Source:Biochem Biophys Res Commun;496(1):25-30, 2018 01 29.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fine regulation of the Ras/mitogen-activating protein kinase (MAPK) pathway is crucial in controlling the survival, proliferation, and development of various types of cells. Ras-activating protein-like 3 (Rasal3) is a T cell-specific Ras GTPase-activating protein that negatively regulates T cell receptor (TCR)-induced activation of Ras/MAPK pathway. Rasal3-deficient mice showed a decreased number of naive T cells because Rasal3 is required for the survival of naive T cells. In the current study, we observed ameliorated Type1 T helper (Th1) cell- and Type2 T helper (Th2) cell-dependent contact hypersensitivity reactions in Rasal3-deficient mice, along with a marked shortage of T cells at regional lymph node. Activated Rasal3-deficient T cells showed an increased cell death with reduced Bcl2 expression, suggesting that Rasal3 is required for the survival of not only naïve T cells but also activated T cells. Collectively, Rasal3 controls the magnitude of inflammatory responses through the survival of both naive T cells and activated T cells in vivo.
[Mh] Termos MeSH primário: Sobrevivência Celular/imunologia
Dermatite de Contato/imunologia
Dermatite de Contato/patologia
Ativação Linfocitária/imunologia
Linfócitos T/imunologia
Proteínas Ativadoras de ras GTPase/imunologia
[Mh] Termos MeSH secundário: Animais
Camundongos
Camundongos Endogâmicos C57BL
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RASAL3 protein, mouse); 0 (ras GTPase-Activating Proteins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180102
[St] Status:MEDLINE


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[PMID]:29297214
[Au] Autor:Diamandopoulos A
[Ti] Título:Medea's Nuptial Gifts: Myth and Biomedical Reality.
[So] Source:Vesalius;22(2 Suppl):14-25, 2016 Dec.
[Is] ISSN:1373-4857
[Cp] País de publicação:Belgium
[La] Idioma:eng
[Ab] Resumo:In all art forms, Medea is mainly represented as the tragic witch from Colchis (contemporary Georgia), who slaughtered her sons and killed her erotic rival Glauke and her father, King Creon of Corinth, by offering an elaborate poisonous nuptial garment. Euripides described the victims' symptoms as a sudden extreme inflammation, leading anyone coming into contact with the garment to death. In other version, the inflammation is described as pure fire. The symptoms resemble what current medical knowledge describes as an immune contact sensitivity reaction. The passages with medical interest from the opera based on this tragedy are presented in the original musical form as well as some similar film and theater scenes. Magnified images of harmful insect's Medea's nuptial gifts are shown and their action is discussed.
[Mh] Termos MeSH primário: Dermatite de Contato/história
Medicina nas Artes/história
Filmes Cinematográficos/história
Música/história
[Mh] Termos MeSH secundário: Animais
República da Geórgia
Doações
História Antiga
Insetos/fisiologia
Mitologia
Comportamento Sexual Animal
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:QIS
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE


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[PMID]:27775978
[Au] Autor:Braunberger T; Lynn D; Reimer C; Doctor M; Hill MK; Mounessa J; Dunnick CA
[Ad] Endereço:From the *University of North Dakota School of Medicine, Grand Forks; †University of Colorado School of Medicine, Aurora; ‡Michigan State University College of Human Medicine, Grand Rapids; §University of Central Florida College of Medicine, Orlando; ∥Department of Dermatology, University of Colorado Denver, Aurora; and ¶Department of Dermatology, Denver Veterans Affairs Medical Center, CO.
[Ti] Título:Disease Severity and Quality of Life Measurements in Contact Dermatitis: A Systematic Review 2005-2015.
[So] Source:Dermatitis;27(6):362-371, 2016 Nov/Dec.
[Is] ISSN:2162-5220
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Contact dermatitis (CD) has been assessed by numerous disease severity indices resulting in heterogeneity across published research. OBJECTIVE: This study aims to evaluate published CD severity scales and identify a criterion standard for assessment. METHODS: Scopus and Ovid MEDLINE were searched for human randomized controlled trials (RCTs) on CD severity measures published during a 10-year period. Eligible studies were English-language RCTs reporting disease severity outcome measures for CD in humans. Studies were excluded if they were duplicates, not available in English, not related to CD, not RCTs, not conducted on human subjects, or did not report relevant outcome measures. RESULTS: A total of 22 disease outcome measures were used in 81 included RCTs. Instrument-based measures were used in 40 (49.4%) studies, and visual assessments were used in 66 (81.5%) RCTs. Only 5 (6.2%) studies reported quality of life (QoL) outcomes. Two (2.5%) studies used a clinical severity scale, which combined both QoL and visual assessments. LIMITATIONS: This study was limited by the exclusion of non-RCTs and gray literature. CONCLUSIONS: Wide variation in CD outcome measures exists including instrument-based measures, visual assessments, and QoL outcomes. A standardized outcome measure must be generated to reduce heterogeneity.
[Mh] Termos MeSH primário: Dermatite de Contato/fisiopatologia
Qualidade de Vida
Índice de Gravidade de Doença
[Mh] Termos MeSH secundário: Dermatite de Contato/psicologia
Seres Humanos
Avaliação de Resultados (Cuidados de Saúde)
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:27776821
[Au] Autor:Pechter E; Rosenman KD
[Ad] Endereço:Occupational Health Surveillance Program, Massachusetts Department of Public Health, Boston, MA. Electronic address: Elise.Pechter@state.ma.us.
[Ti] Título:Occupational health risks associated with use of environmental surface disinfectants in health care.
[So] Source:Am J Infect Control;44(12):1755-1756, 2016 12 01.
[Is] ISSN:1527-3296
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Asma/induzido quimicamente
Asma/epidemiologia
Dermatite de Contato/epidemiologia
Desinfetantes/efeitos adversos
Exposição Ocupacional
[Mh] Termos MeSH secundário: Instalações de Saúde
Seres Humanos
Medição de Risco
[Pt] Tipo de publicação:LETTER; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Disinfectants)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:28819080
[Au] Autor:Kabe I; Tsuruoka H; Kochi T; Koga Y; Eguchi M; Matsui T; Ito R; Tokujitani Y; Miyauchi H; Tanaka S
[Ad] Endereço:Furukawa Electric Co. Ltd.
[Ti] Título:A survey on selection, use, maintenance, and management of chemical protective gloves at workplaces in Japan.
[So] Source:Sangyo Eiseigaku Zasshi;59(5):135-143, 2017 10 05.
[Is] ISSN:1349-533X
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:OBJECTIVES: The aim of this study was to survey the selection, use, and maintenance of chemical protective gloves (CPGs) at real workplaces. METHODS: Subjects comprised 817 workers using CPGs at seven domestic manufacturing plants in Japan. We administered an anonymous questionnaire survey comprising the following aspect related to CPGs: environment of use, conditions of use, method of selection, knowledge/awareness pertaining to their use, method of use, precautionary measures associated with their use, maximum time of use, and maintenance. We compared responses provided by management staff and field workers. Chi square test was used for the analysis. RESULTS: Respondents included 661 (80.9%) manufacturing workers, 121 (14.8%) managers or supervisors, and 35 (4.3%) others. In total, 70.5% organic solvents, 28.9% acid or/and alkali, 18.1% dust, and 10.3% carcinogenic substances were the chemical substances handled using CPGs. The reason for deciding to wear CPGs was "the use of chemical substances" for 46.5%, "notice in safety data sheet (SDS) " for 29.8%, and "management staffs' guidance" for 21.4% respondents. "The grasp of chemical substances" was 70.1% (91.1% excluding "not applicable" ). "Warning of caution on skin and eyes" was indicated by 69.5% (91.0%) and "educational reasons for use of CPGs" was accepted by 68.1% (90.7%) respondents. On the other hand, the rate of responses such as "obtaining permeability test results of target substances" and "mixed substances are selected considering substances with short permeation time" was 25.2% (38.4%) and 29.2% (48.4%), respectively. The rate of "yes" as a response in the item concerning "permeation test" was low. On comparing the response provided by the management staff and field workers, the rate of "the permeation test result of the target substance was obtained" was 27.7% for management staff and 41.2% for field workers (p = 0.022). Regarding the cuffs of CPGs, the rate of "to fold back and to prevent sagging" and "mounted with tape" were 30.5% and 21.8% for management staff and 50.2% and 42.2% for field workers (p = 0.001 and p = 0.001), respectively. DISCUSSION: This survey results suggested that the knowledge of "permeation test" of CPGs was not yet popular at industrial workplaces. It is necessary to disseminate knowledge related to "permeation test" to the users from manufacturers of CPGs. Additionally, the employer should appoint an administrator to ensure that CPGs are worn and increase the understanding of correct knowledge and usage of CPGs among workers.
[Mh] Termos MeSH primário: Indústria Química/estatística & dados numéricos
Luvas Protetoras/utilização
Saúde do Trabalhador
Local de Trabalho/estatística & dados numéricos
[Mh] Termos MeSH secundário: Dermatite de Contato/prevenção & controle
Dermatite Ocupacional/prevenção & controle
Seres Humanos
Japão/epidemiologia
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE
[do] DOI:10.1539/sangyoeisei.17-005-E


  9 / 13461 MEDLINE  
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[PMID]:28691226
[Au] Autor:Casorati G; Dellabona P
[Ad] Endereço:Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milano, Italy.
[Ti] Título:Of self-lipids, CD1-restricted T cells, and contact sensitization.
[So] Source:Eur J Immunol;47(7):1119-1122, 2017 Jul.
[Is] ISSN:1521-4141
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Contact hypersensitivity (CHS) in rodents and contact dermatitis in humans are long-known pathological conditions caused by MHC-restricted T-cell responses. These responses are triggered upon T-cell recognition of neo-antigenic determinants, which are generated by a variety of environmental contact sensitizer (CS) chemicals associating with self-proteins to comprise these neo-antigens. In this issue of the European Journal of Immunology, Betts et al. [Eur. J. Immunol. 2017. 47: 1171-1180] provide intriguing data implying that common small molecule CSs such as dinitrochlorobenzene can also recruit and activate autoreactive CD1-restricted T cells specific for cell-endogenous lipids, which are enriched in human skin. The effects of dinitrochlorobenzene on CD1 T-cell recruitment and function were dependent on newly synthesized CD1 molecules and the presence of endogenous lipids. These findings shed new light on unanticipated mechanisms that have potential clinical relevance on a common and highly distressing disease state.
[Mh] Termos MeSH primário: Antígenos CD1/imunologia
Dermatite de Contato/imunologia
Lipídeos/imunologia
Linfócitos T/imunologia
[Mh] Termos MeSH secundário: Animais
Apresentação do Antígeno
Seres Humanos
Camundongos
Células T Matadoras Naturais/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD1); 0 (Lipids)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE
[do] DOI:10.1002/eji.201747112


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[PMID]:28687491
[Au] Autor:Hirunwidchayarat W; Furusawa E; Kang S; Ohno T; Takeuchi S; Rungsiyanont S; Azuma M
[Ad] Endereço:Department of Molecular Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan; Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, Srinakharinwirote University, 114 Sukhumvit 23, Wattana District, Bang
[Ti] Título:Site-specific regulation of oral mucosa-recruiting CD8 T cells in a mouse contact allergy model.
[So] Source:Biochem Biophys Res Commun;490(4):1294-1300, 2017 Sep 02.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Contact allergy is a T cell-mediated, delayed-type hypersensitivity generated by contact exposure of an allergen to the skin and mucosal surface. The clinical manifestations of allergic responses between the skin and oral mucosa vary and the differences in immunopathology have not been clarified. We generated hapten-induced contact hypersensitivity (CH) of the buccal mucosa (BM) in parallel studies with ear skin (ES) CH, and observed several characteristic findings of BM CH. The BM challenge induced more rapid and more severe inflammation than the ES challenge, with abundant granulocyte and CD8 T cell infiltration. However, these inflammatory responses diminished quickly. Recruiting CD8 T cells in the BM had higher ratios of CD62L CD44 memory-type cells, and showed impaired IFN-γ, greater PD-1, and comparable Ki-67 expression, suggesting that the recruiting-proliferating CD8 T cells were unable to differentiate into effector T cells and converted into exhausted T cells at the local site. This finding may explain the rapid recovery of the BM from severe inflammation. Preferentially greater expression of PD-1 ligand (B7-H1), was observed in the BM epithelium under the peak inflammation, and the absence of B7-H1 further accelerated CH responses, suggesting the occurrence of PD-1:B7-H1-mediated immune regulation at the local site. Our results may facilitate the understanding of the unique features of contact allergies in the oral mucosa, and guide the development of new strategies for control of contact allergy.
[Mh] Termos MeSH primário: Linfócitos T CD8-Positivos/imunologia
Dermatite de Contato/imunologia
Granulócitos/imunologia
Mucosa Bucal/imunologia
Pele/imunologia
[Mh] Termos MeSH secundário: Animais
Antígeno B7-H1/genética
Antígeno B7-H1/imunologia
Linfócitos T CD8-Positivos/efeitos dos fármacos
Linfócitos T CD8-Positivos/patologia
Dermatite de Contato/etiologia
Dermatite de Contato/genética
Dermatite de Contato/patologia
Dinitrofluorbenzeno/toxicidade
Orelha
Feminino
Regulação da Expressão Gênica
Granulócitos/efeitos dos fármacos
Granulócitos/patologia
Receptores de Hialuronatos/genética
Receptores de Hialuronatos/imunologia
Memória Imunológica
Imunofenotipagem
Interferon gama/genética
Interferon gama/imunologia
Antígeno Ki-67/genética
Antígeno Ki-67/imunologia
Selectina L/genética
Selectina L/imunologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Mucosa Bucal/efeitos dos fármacos
Mucosa Bucal/patologia
Especificidade de Órgãos
Receptor de Morte Celular Programada 1/genética
Receptor de Morte Celular Programada 1/imunologia
Transdução de Sinais
Pele/efeitos dos fármacos
Pele/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (B7-H1 Antigen); 0 (CD274 protein, human); 0 (Cd44 protein, mouse); 0 (Hyaluronan Receptors); 0 (Ki-67 Antigen); 0 (Mki67 protein, mouse); 0 (PDCD1 protein, human); 0 (Programmed Cell Death 1 Receptor); 126880-86-2 (L-Selectin); 82115-62-6 (Interferon-gamma); D241E059U6 (Dinitrofluorobenzene)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170709
[St] Status:MEDLINE



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