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[PMID]:28329062
[Au] Autor:Tan KW; Haylett AK; Ling TC; Rhodes LE
[Ad] Endereço:Photobiology Unit, Dermatology Centre, University of Manchester, Manchester, England2Academic Health Science Centre, Salford Royal NHS (National Health Service) Foundation Trust, Salford, England3Department of Dermatology, Changi General Hospital, Singapore.
[Ti] Título:Comparison of Demographic and Photobiological Features of Chronic Actinic Dermatitis in Patients With Lighter vs Darker Skin Types.
[So] Source:JAMA Dermatol;153(5):427-435, 2017 May 01.
[Is] ISSN:2168-6084
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Chronic actinic dermatitis (CAD) is classically described in older, white men, although increasing reports describe younger patients with darker skin types, particularly South Asians. Photocontact allergy occurs in CAD but is less studied than contact allergy in this exquisitely photosensitive condition. Objective: To evaluate for differences in demographic and photobiological features between persons with darker and lighter skin types who have CAD. Design, Setting, and Participants: This retrospective review included 70 consecutive adult patients (≥18 years) undergoing investigation for photosensitivity who were diagnosed with CAD from November 1, 2000, through August 31, 2015, at the specialist Photobiology Unit of a tertiary academic referral center. Main Outcomes and Measures: Patient age, sex, ethnicity, clinical features, and phototesting outcomes. Results: A total of 70 patients (37 men [53%] and 33 women [47%]; mean [SD] age, 50.9 [2.3] years) were diagnosed with CAD. Of these, 36 were non-Hispanic and non-Latino white, 31 were Asian (including 24 South Asian, 4 East Asian, and 3 Middle Eastern), and 3 were black. Patients were aged 9 to 83 years at diagnosis, with a mean (SD) age at onset of 42.6 (2.4) years and duration of disease of 8.8 (1.3) years. Forty-one had lighter skin types (Fitzpatrick skin types I-IV), and 29 had darker skin types (Fitzpatrick skin types V and VI). Patients with darker skin types and CAD were younger at diagnosis (mean [SD] age, 40.7 [3.5] vs 58.1 [2.5] years; P < . 001) and had earlier onset of photosensitivity (mean [SD] age, 35.5 [3.9] vs 47.5 [2.9] years; P = .01) compared with patients with lighter skin types. Of note, the male to female ratio in the lighter skin group was 2:1 compared with 1:2 in the darker skin group. Phototest reactions were equally severe in Fitzpatrick skin types V to VI and I to IV, with minimal erythemal doses to monochromatic UV-B, UV-A, and visible radiation and broadband provocation testing showing similar results. Photoallergic contact reactions to UV filters, personal sunscreen products, and nonsteroidal anti-inflammatory drugs were seen in both groups; 14 of 61 patients (23%) undergoing photopatch testing showed positive photopatch reactions. Conclusions and Relevance: Chronic actinic dermatitis presents with an earlier age at onset and an inverted male to female ratio in patients with darker compared with lighter skin types. Clinicians should thus be cognizant of CAD in younger women with darker skin types. Photopatch testing should be considered in patients with CAD, with coexistent photocontact allergy occurring in a substantial proportion.
[Mh] Termos MeSH primário: Dermatite Fotoalérgica/epidemiologia
Testes do Emplastro
Transtornos de Fotossensibilidade/epidemiologia
Pigmentação da Pele
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idade de Início
Idoso
Idoso de 80 Anos ou mais
Criança
Dermatite Fotoalérgica/diagnóstico
Dermatite Fotoalérgica/patologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Transtornos de Fotossensibilidade/patologia
Estudos Retrospectivos
Fatores Sexuais
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE
[do] DOI:10.1001/jamadermatol.2016.5861


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[PMID]:27957757
[Au] Autor:Martina E; Rosa L; Postacchini V; Simonetti O; Cataldi I; Offidani A
[Ad] Endereço:Dermatology Clinic, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60100 Torrette-Ancona, Italy.
[Ti] Título:Photoprotection and photodermatitis: a case.
[So] Source:Contact Dermatitis;76(1):54-55, 2017 Jan.
[Is] ISSN:1600-0536
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Acrilatos/efeitos adversos
Dermatite Fotoalérgica/etiologia
Protetores Solares/efeitos adversos
[Mh] Termos MeSH secundário: Abdome
Seres Humanos
Masculino
Meia-Idade
Tórax
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylates); 0 (Sunscreening Agents); 5A68WGF6WM (octocrylene)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161214
[St] Status:MEDLINE
[do] DOI:10.1111/cod.12644


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[PMID]:27544569
[Au] Autor:Consuegra Romero G; Castro Gutiérrez B; González López MA
[Ad] Endereço:Department of Dermatology, Marqués de Valdecilla University Hospital, Ave. Valdecilla S/N, 39008 Santander, Spain. Electronic address: gigiconsuegra@hotmail.com.
[Ti] Título:Photoallergic contact dermatitis.
[So] Source:Eur J Intern Med;38:e4-e5, 2017 Mar.
[Is] ISSN:1879-0828
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/efeitos adversos
Dermatite Fotoalérgica/diagnóstico
Cetoprofeno/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Anti-Inflamatórios não Esteroides/administração & dosagem
Dermatite Fotoalérgica/etiologia
Seres Humanos
Cetoprofeno/administração & dosagem
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 90Y4QC304K (Ketoprofen)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160822
[St] Status:MEDLINE


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[PMID]:27528585
[Au] Autor:Onoue S; Seto Y; Sato H; Nishida H; Hirota M; Ashikaga T; Api AM; Basketter D; Tokura Y
[Ad] Endereço:Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address: onoue@u-shizuoka-ken.ac.jp.
[Ti] Título:Chemical photoallergy: photobiochemical mechanisms, classification, and risk assessments.
[So] Source:J Dermatol Sci;85(1):4-11, 2017 Jan.
[Is] ISSN:1873-569X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Chemical photosensitivity can be elicited by exposure of the skin to various pharmaceutical substances, foods, cosmetics and other environmental chemicals, followed by exposure to sunlight. There are at least three types of chemical photosensitivity, i.e., photoirritancy (narrowly defined as phototoxicity), photogenotoxicity and photoallergenicity, and their clinical characteristics and mechanisms are quite different. Concerns about chemical photoallergy is increasing, and various studies have been made to clarify the photobiochemical characteristics of photoallergens and the mechanisms involved. Various methodologies, including in silico prediction models, photochemical assay systems, and in vitro phototoxicity prediction tools, have been developed to predict the photoallergenic potential of chemicals over the past few years. The aim of this manuscript is to review the clinical characteristics, pathogenetic mechanisms and photobiochemical features of photoallergens, with special emphasis on the current status about development of screening systems for predicting photoallergenic potential of chemicals.
[Mh] Termos MeSH primário: Alérgenos/efeitos adversos
Distúrbios Induzidos Quimicamente/etiologia
Dermatite Fotoalérgica/etiologia
Dermatite Fototóxica/etiologia
Medição de Risco
Raios Ultravioleta/efeitos adversos
[Mh] Termos MeSH secundário: Cosméticos/efeitos adversos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/etiologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Allergens); 0 (Cosmetics)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170330
[Lr] Data última revisão:
170330
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160817
[St] Status:MEDLINE


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[PMID]:27510322
[Au] Autor:Khandpur S; Porter RM; Boulton SJ; Anstey A
[Ad] Endereço:Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
[Ti] Título:Drug-induced photosensitivity: new insights into pathomechanisms and clinical variation through basic and applied science.
[So] Source:Br J Dermatol;176(4):902-909, 2017 Apr.
[Is] ISSN:1365-2133
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Drug-induced photosensitivity occurs when a drug is capable of absorbing radiation from the sun (usually ultraviolet A) leading to chemical reactions that cause cellular damage (phototoxicity) or, more rarely, form photoallergens (photoallergy). The manifestation varies considerably in presentation and severity from mild pain to severe blistering. Despite screening strategies and guidelines in place to predict photoreactive drugs during development there are still new drugs coming onto the market that cause photosensitivity. Thus, there is a continuing need for dermatologists to be aware of the different forms of presentation and the culprit drugs. Management usually involves photoprotection and cessation of drug treatment. However, there are always cases where the culprit drug is indispensable. The reason why some patients are susceptible while others remain asymptomatic is not known. A potential mechanism for the phototoxic reactions is the generation of reactive oxygen species (ROS), and there are a number of reasons why some patients might be less able to cope with enhanced levels of ROS.
[Mh] Termos MeSH primário: Transtornos de Fotossensibilidade/induzido quimicamente
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Dermatite Fotoalérgica/etiologia
Dermatite Fototóxica/etiologia
Diagnóstico Precoce
Seres Humanos
Hiperpigmentação/induzido quimicamente
Queratinócitos/fisiologia
Dor/induzido quimicamente
Pelagra/induzido quimicamente
Transtornos de Fotossensibilidade/diagnóstico
Transtornos de Fotossensibilidade/terapia
Porfirias/induzido quimicamente
Espécies Reativas de Oxigênio/farmacologia
Pigmentação da Pele/efeitos dos fármacos
Queimadura Solar/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Reactive Oxygen Species)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171105
[Lr] Data última revisão:
171105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160812
[St] Status:MEDLINE
[do] DOI:10.1111/bjd.14935


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[PMID]:27638435
[Au] Autor:Monteiro AF; Rato M; Martins C
[Ad] Endereço:Department of Dermatovenereology, Hospital Distrital de Santarém EPE, Santarém, Portugal. Electronic address: Afilipe.monteiro@hds.min-saude.pt.
[Ti] Título:Drug-induced photosensitivity: Photoallergic and phototoxic reactions.
[So] Source:Clin Dermatol;34(5):571-81, 2016 Sep-Oct.
[Is] ISSN:1879-1131
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Drug-induced photosensitivity refers to the development of cutaneous disease due to the interaction between a given chemical agent and sunlight. Photosensitivity reactions can be classified as phototoxic or photoallergic. Sometimes, there is an overlap between these two patterns, making their distinction particularly difficult for the clinician. We review the drugs that have been implicated as photosensitizers, the involved mechanism, and their clinical presentations. The main topical agents that cause contact photosensitivity are the nonsteroidal antiinflammatory drugs, whereas the main systemic drugs inducing photosensitivity are antimicrobials, nonsteroidal antiinflammatory agents, and cardiovascular drugs. Drug-induced photosensitivity remains a common clinical problem and is often underdiagnosed.
[Mh] Termos MeSH primário: Anti-Infecciosos/efeitos adversos
Dermatite Fotoalérgica/etiologia
Dermatite Fototóxica/etiologia
[Mh] Termos MeSH secundário: Administração Cutânea
Administração Oral
Antiarrítmicos/efeitos adversos
Anti-Inflamatórios não Esteroides/efeitos adversos
Anti-Hipertensivos/efeitos adversos
Antineoplásicos/efeitos adversos
Dermatite Fotoalérgica/diagnóstico
Dermatite Fototóxica/diagnóstico
Seres Humanos
Inibidores de Hidroximetilglutaril-CoA Redutases/efeitos adversos
Psicotrópicos/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Arrhythmia Agents); 0 (Anti-Infective Agents); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Antihypertensive Agents); 0 (Antineoplastic Agents); 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors); 0 (Psychotropic Drugs)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160918
[St] Status:MEDLINE


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[PMID]:27337844
[Au] Autor:Piérard GE; Piérard-Franchimont C
[Ti] Título:[INABILITY TO TOLERATE COSMETICS].
[Ti] Título:INTOLÉRANCE AUX COSMÉTIQUES..
[So] Source:Rev Med Liege;71(5):248-51, 2016 May.
[Is] ISSN:0370-629X
[Cp] País de publicação:Belgium
[La] Idioma:fre
[Ab] Resumo:Inability to tolerate cosmetics can result from distinct mechanisms which appear as the so-called sensitive skin corresponding to one aspect of invisible dermatosis, or which corresponds to manifestations of a contact allergic or irritation dermatitis.
[Mh] Termos MeSH primário: Cosméticos/efeitos adversos
Dermatite Alérgica de Contato/etiologia
[Mh] Termos MeSH secundário: Cosméticos/farmacocinética
Dermatite Fotoalérgica/etiologia
Seres Humanos
Absorção Cutânea/imunologia
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Cosmetics)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160624
[Lr] Data última revisão:
160624
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160625
[St] Status:MEDLINE


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[PMID]:27185422
[Au] Autor:Mowad CM; Anderson B; Scheinman P; Pootongkam S; Nedorost S; Brod B
[Ad] Endereço:Department of Dermatology, Geisinger Medical Center, Danville, Pennsylvania. Electronic address: cmowad@geisinger.edu.
[Ti] Título:Allergic contact dermatitis: Patient management and education.
[So] Source:J Am Acad Dermatol;74(6):1043-54, 2016 Jun.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Allergic contact dermatitis is a common diagnosis resulting from exposure to a chemical or chemicals in a patient's personal care products, home, or work environment. Once patch testing has been performed, the education and management process begins. After the causative allergens have been identified, patient education is critical to the proper treatment and management of the patient. This must occur if the dermatitis is to resolve. Detailed education is imperative, and several resources are highlighted. Photoallergic contact dermatitis and occupational contact dermatitis are other considerations a clinician must keep in mind.
[Mh] Termos MeSH primário: Alérgenos/imunologia
Dermatite Alérgica de Contato/diagnóstico
Dermatite Alérgica de Contato/terapia
Gerenciamento Clínico
Educação de Pacientes como Assunto
[Mh] Termos MeSH secundário: Dermatite Ocupacional/diagnóstico
Dermatite Ocupacional/terapia
Dermatite Fotoalérgica/diagnóstico
Dermatite Fotoalérgica/terapia
Feminino
Seres Humanos
Masculino
Testes do Emplastro/métodos
Fatores de Risco
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Allergens)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160518
[St] Status:MEDLINE


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[PMID]:27040881
[Au] Autor:Ngarmjiratam N; Wattanakrai P
[Ad] Endereço:Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
[Ti] Título:Photoallergic contact dermatitis caused by Quisqualis indica (Combretum indicum).
[So] Source:Contact Dermatitis;74(5):313-4, 2016 May.
[Is] ISSN:1600-0536
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Combretum/efeitos adversos
Dermatite Alérgica de Contato/etiologia
Dermatite Fotoalérgica/etiologia
Jardinagem
[Mh] Termos MeSH secundário: Dermatite Alérgica de Contato/diagnóstico
Dermatite Fotoalérgica/diagnóstico
Feminino
Seres Humanos
Meia-Idade
Testes do Emplastro
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170112
[Lr] Data última revisão:
170112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160405
[St] Status:MEDLINE
[do] DOI:10.1111/cod.12538


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[PMID]:27007836
[Au] Autor:Silpa-Archa N; Wongpraparut C; Leenutaphong V
[Ad] Endereço:Department of Dermatology Faculty of Medicine Siriraj Hospital, Mahidol University 2 Wanglang Road, Bangkoknoi, Bangkok, THAILAND 10700.
[Ti] Título:Analysis of solar urticaria in Thai patients.
[So] Source:Asian Pac J Allergy Immunol;34(2):146-52, 2016 Jun.
[Is] ISSN:0125-877X
[Cp] País de publicação:Thailand
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Solar urticaria (SU) is an uncommon photodermatosis characterized by erythema and whealing within minutes to a few hours after exposure to sunlight or an artificial light source. OBJECTIVE: To determine the clinical features, photobiological characteristics and treatment outcomes in Thai SU patients visiting a tertiary referral hospital. METHOD: A retrospective analysis of 13 patients with SU was conducted. Demographic data, disease characters, phototesting results, laboratory investigations, treatment and outcome were evaluated. RESULTS: Of the 13 patients diagnosed with SU from 2000 to 2012, most patients were female (10, 77%). The mean age of onset was 29 years (15-51). The mean duration of SU was 46 months (6-120) at presentation. The most common affected location was the upper extremities (92%), followed by head and neck (77%). The responsible action spectra were visible light in 8 patients (61.5%), ultraviolet A (UVA) in 1 patient (8%), and both visible light and UVA in 4 patients (31%). The median course from disease onset to disease resolution was 63 months (95% confidence interval 30-95). After 13 months and 55 months from the onset of symptoms, 23% and 49% of patients, respectively, were predicted to recover from their symptoms. CONCLUSION: Solar urticaria is a rare condition in Thailand. The common eliciting spectra of SU were visible light and UVA. Management of SU remains challenging.
[Mh] Termos MeSH primário: Dermatite Fotoalérgica/etiologia
Pele/efeitos da radiação
Luz Solar/efeitos adversos
Raios Ultravioleta/efeitos adversos
Urticária/etiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Dermatite Fotoalérgica/diagnóstico
Dermatite Fotoalérgica/terapia
Feminino
Seres Humanos
Masculino
Meia-Idade
Indução de Remissão
Estudos Retrospectivos
Fatores de Risco
Pele/patologia
Centros de Atenção Terciária
Tailândia
Fatores de Tempo
Resultado do Tratamento
Urticária/diagnóstico
Urticária/terapia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170117
[Lr] Data última revisão:
170117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160324
[St] Status:MEDLINE
[do] DOI:10.12932/AP0632.34.2.2016



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