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  1 / 1887 MEDLINE  
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[PMID]:29200239
[Au] Autor:Ruhanen H; Wastimo S; Reinikainen M
[Ti] Título:Hypothermia caused by psoriasis.
[So] Source:Duodecim;133(1):85-7, 2017.
[Is] ISSN:0012-7183
[Cp] País de publicação:Finland
[La] Idioma:eng
[Ab] Resumo:Severe psoriasis can lead to erythroderma, which is a widespread inflammatory condition of the skin. Erythroderma increases the amount of water evaporating from the skin and heat loss. We present a case of severe hypothermia with rectal temperature of 29.3 °C caused by psoriasis and a septic infection.
[Mh] Termos MeSH primário: Dermatite Esfoliativa/complicações
Hipotermia/etiologia
Psoríase/complicações
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


  2 / 1887 MEDLINE  
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[PMID]:28458440
[Au] Autor:Pai SB; Sudershan B; Kuruvilla M; Kamath A; Suresh PK
[Ad] Endereço:Department of Pharmacology, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India.
[Ti] Título:Hydroxychloroquine-induced erythroderma.
[So] Source:Indian J Pharmacol;49(1):132-134, 2017 Jan-Feb.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Erythroderma is characterized by diffuse erythema and scaling of the skin involving more than 90% of the total body skin surface area. Drug-induced erythroderma has rarely been reported with hydroxychloroquine. We report a case of a 50-year-old female patient, with systemic lupus erythematosus, who developed itchy lesions all over the body 1 month after starting treatment with hydroxychloroquine. Drug-induced erythroderma was suspected. Hydroxychloroquine was withdrawn and the patient was treated with emollients, mid-potency corticosteroids, and oral antihistamines. A biopsy was done which confirmed the diagnosis of erythroderma. She recovered with treatment and was discharged. A careful history and clinical examination to search for potential causative factors will help prevent disabling sequelae in erythroderma.
[Mh] Termos MeSH primário: Dermatite Esfoliativa/induzido quimicamente
Erupção por Droga/diagnóstico
Hidroxicloroquina/efeitos adversos
[Mh] Termos MeSH secundário: Antirreumáticos/administração & dosagem
Antirreumáticos/efeitos adversos
Biópsia
Dermatite Esfoliativa/diagnóstico
Dermatite Esfoliativa/patologia
Erupção por Droga/etiologia
Erupção por Droga/patologia
Feminino
Seres Humanos
Hidroxicloroquina/administração & dosagem
Lúpus Eritematoso Sistêmico/tratamento farmacológico
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antirheumatic Agents); 4QWG6N8QKH (Hydroxychloroquine)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.4103/0253-7613.201027


  3 / 1887 MEDLINE  
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[PMID]:29245252
[Au] Autor:Gui X; Zhu X; Guo L; Tan G; Liu Y; Tan Y; Chen Q; Song Y; Lin S
[Ad] Endereço:aDepartment of Oncology, The First Affiliated Hospital of Jinan UniversitybDepartment of Traditional Chinese Medicine, The First Affiliated Hospital of Jinan UniversitycDepartment of Central Laboratory, The First Affiliated Hospital of Jinan UniversitydDepartment of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.
[Ti] Título:Graft-versus-host disease-like erythroderma: a sign of recurrent thymoma: A case report.
[So] Source:Medicine (Baltimore);96(49):e8877, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Thymomas are associated with numerous autoimmune disorders, such as myasthenia gravis (MG), pure red cell aplasia (PRCA), and systemic lupus erythematosus (SLE). However, graft-versus-host disease (GVHD)-like erythroderma is a relatively uncommon paraneoplastic disorder associated with thymomas and signifies a poor prognosis. PATIENT CONCERNS: A 35-year-old woman with medical history significant for stage IVa type AB thymoma presented with patchy erythema over face, trunk, and extremities that failed to respond to topical steroids. DIAGNOSIS: A contrast-enhanced computerized tomography (CECT) scan of the chest demonstrated tumors in the right mediastinum and right pleura. Percutaneous right mediastinal pleural biopsy confirmed recurrent thymoma (WHO type B3, Masaoka stage IVb). Histopathologic examination of her skin lesions revealed GVHD-like erythroderma. INTERVENTIONS: The patient received chemotherapy and local thoracic radiotherapy, as well as corticosteroids. OUTCOMES: The eruptions gradually subsided with hyperpigmentation; however the patient eventually died of multiple organ failure. LESSONS: GVHD-like erythroderma is an uncommon paraneoplastic disorder associated with thymomas. Though its pathogenesis still needs further research, prompt diagnosis and appropriate treatment can improve survival rate in patients.
[Mh] Termos MeSH primário: Dermatite Esfoliativa/patologia
Doença Enxerto-Hospedeiro/patologia
Recidiva Local de Neoplasia/diagnóstico por imagem
Recidiva Local de Neoplasia/patologia
Timoma/diagnóstico por imagem
Timoma/patologia
Neoplasias do Timo/diagnóstico por imagem
Neoplasias do Timo/patologia
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Adulto
Meios de Contraste
Diagnóstico Diferencial
Evolução Fatal
Feminino
Seres Humanos
Estadiamento de Neoplasias
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171225
[Lr] Data última revisão:
171225
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008877


  4 / 1887 MEDLINE  
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[PMID]:27771215
[Au] Autor:Aviv R; Toh J; Eisenberg R; Khanna S; Jariwala SP
[Ad] Endereço:Department of Medicine, Kaiser Permanente, San Jose, California.
[Ti] Título:Zinc deficiency presenting as diarrhea and diffuse erythroderma.
[So] Source:Ann Allergy Asthma Immunol;117(6):707-708, 2016 Dec.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Dermatite Esfoliativa/patologia
Diarreia/patologia
Zinco/deficiência
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Meia-Idade
Linfócitos T/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  5 / 1887 MEDLINE  
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[PMID]:28709694
[Au] Autor:Mangold AR; Thompson AK; Davis MD; Saulite I; Cozzio A; Guenova E; Hodak E; Amitay-Laish I; Pujol RM; Pittelkow MR; Gniadecki R
[Ad] Endereço:Mayo Clinic, Scottsdale, Arizona. Electronic address: mangold.aaron@mayo.edu.
[Ti] Título:Early clinical manifestations of Sézary syndrome: A multicenter retrospective cohort study.
[So] Source:J Am Acad Dermatol;77(4):719-727, 2017 Oct.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Classic Sézary syndrome (SS) is defined by erythroderma, generalized lymphadenopathy, and leukemic blood involvement. Clinical observations suggest that SS begins as a nonerythrodermic disease. OBJECTIVE: To describe the early clinical characteristics of patients with SS. METHODS: A retrospective, multicenter chart review was performed for 263 confirmed cases of SS diagnosed during 1976-2015. RESULTS: Erythroderma was the earliest recorded skin sign of SS in only 25.5% of cases, although most patients (86.3%) eventually developed erythroderma. In patients without erythroderma during their initial visit, the first cutaneous signs of SS were nonspecific dermatitis (49%), atopic dermatitis-like eruption (4.9%), or patches and plaques of mycosis fungoides (10.6%). The mean diagnostic delay was 4.2 years overall, 2.2 years for cases involving erythroderma at the initial presentation, and 5.0 years for cases not involving erythroderma at the initial presentation. LIMITATIONS: This study is retrospective. CONCLUSION: Erythroderma is uncommon as an initial sign of SS. Early SS should be considered in cases of nonerythrodermic dermatitis that is refractory to conventional treatments. In these cases, examination of the blood by PCR for monoclonal T-cell receptor rearrangement and by flow cytometry to identify an expanded or aberrant T-cell population should be considered.
[Mh] Termos MeSH primário: Dermatite Esfoliativa/etiologia
Micose Fungoide/etiologia
Síndrome de Sézary/diagnóstico
Síndrome de Sézary/patologia
[Mh] Termos MeSH secundário: Idoso
Biópsia
Diagnóstico Tardio
Dermatite/etiologia
Feminino
Seres Humanos
Linfadenopatia/etiologia
Masculino
Meia-Idade
Prognóstico
Receptores de Antígenos de Linfócitos T/genética
Estudos Retrospectivos
Síndrome de Sézary/complicações
Pele/patologia
Taxa de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Receptors, Antigen, T-Cell)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170716
[St] Status:MEDLINE


  6 / 1887 MEDLINE  
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[PMID]:28404562
[Au] Autor:Quay ER; Lam C
[Ad] Endereço:Department of Dermatology, Boston University Medical Center, Boston, MA, USA.
[Ti] Título:An important cause of erythroderma.
[So] Source:BMJ;357:j1205, 2017 04 12.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Dermatite Esfoliativa/etiologia
Escabiose/complicações
[Mh] Termos MeSH secundário: Idoso
Antiparasitários/uso terapêutico
Dermatite Esfoliativa/diagnóstico
Dermatite Esfoliativa/tratamento farmacológico
Dermatite Esfoliativa/patologia
Diagnóstico Diferencial
Seres Humanos
Ivermectina/uso terapêutico
Masculino
Permetrina/uso terapêutico
Escabiose/diagnóstico
Escabiose/tratamento farmacológico
Escabiose/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiparasitic Agents); 509F88P9SZ (Permethrin); 70288-86-7 (Ivermectin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170721
[Lr] Data última revisão:
170721
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j1205


  7 / 1887 MEDLINE  
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[PMID]:28301507
[Au] Autor:Gros A; Laharanne E; Vergier M; Prochazkova-Carlotti M; Pham-Ledard A; Bandres T; Poglio S; Berhouet S; Vergier B; Vial JP; Chevret E; Beylot-Barry M; Merlio JP
[Ad] Endereço:INSERM U1053, Bordeaux Research in Translational Oncology University Bordeaux, Bordeaux, France.
[Ti] Título:TP53 alterations in primary and secondary Sézary syndrome: A diagnostic tool for the assessment of malignancy in patients with erythroderma.
[So] Source:PLoS One;12(3):e0173171, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent massive parallel sequencing data have evidenced the genetic diversity and complexity of Sézary syndrome mutational landscape with TP53 alterations being the most prevalent genetic abnormality. We analyzed a cohort of 35 patients with SS and a control group of 8 patients with chronic inflammatory dermatoses. TP53 status was analyzed at different clinical stages especially in 9 patients with a past-history of mycosis fungoides (MF), coined secondary SS. TP53 mutations were only detected in 10 patients with either primary or secondary SS (29%) corresponding to point mutations, small insertions and deletions which were unique in each case. Interestingly, TP53 mutations were both detected in sequential unselected blood mononuclear cells and in skin specimens. Cytogenetic analysis of blood specimens of 32 patients with SS showed a TP53 deletion in 27 cases (84%). Altogether 29 out of 35 cases exhibited TP53 mutation and/or deletion (83%). No difference in prognosis was observed according to TP53 status while patients with secondary SS had a worse prognosis than patients with primary SS. Interestingly, patients with TP53 alterations displayed a younger age and the presence of TP53 alteration at initial diagnosis stage supports a pivotal oncogenic role for TP53 mutation in SS as well as in erythrodermic MF making TP53 assessment an ancillary method for the diagnosis of patients with erythroderma as patients with inflammatory dermatoses did not display TP53 alteration.
[Mh] Termos MeSH primário: Dermatite Esfoliativa/complicações
Genes p53
Síndrome de Sézary/genética
Neoplasias Cutâneas/genética
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Estudos de Coortes
Variações do Número de Cópias de DNA
Feminino
Citometria de Fluxo
Seres Humanos
Hibridização in Situ Fluorescente
Masculino
Meia-Idade
Polimorfismo de Nucleotídeo Único
Síndrome de Sézary/complicações
Neoplasias Cutâneas/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0173171


  8 / 1887 MEDLINE  
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[PMID]:28211348
[Au] Autor:Oda T; Sawada Y; Yamaguchi T; Ohmori S; Omoto D; Haruyama S; Yoshioka M; Okada E; Nakamura M
[Ad] Endereço:Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan.
[Ti] Título:Psoriatic Erythroderma Caused by Terbinafine: A Possible Pathogenetic Role for IL-23.
[So] Source:J Investig Allergol Clin Immunol;27(1):63-64, 2017.
[Is] ISSN:1018-9068
[Cp] País de publicação:Spain
[La] Idioma:eng
[Mh] Termos MeSH primário: Antifúngicos/efeitos adversos
Dermatite Esfoliativa/induzido quimicamente
Erupção por Droga/etiologia
Interleucina-23/imunologia
Naftalenos/efeitos adversos
Psoríase/induzido quimicamente
Pele/efeitos dos fármacos
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Betametasona/administração & dosagem
Betametasona/análogos & derivados
Biópsia
Células Cultivadas
Dermatite Esfoliativa/diagnóstico
Dermatite Esfoliativa/tratamento farmacológico
Dermatite Esfoliativa/imunologia
Erupção por Droga/diagnóstico
Erupção por Droga/tratamento farmacológico
Erupção por Droga/imunologia
Feminino
Glucocorticoides/administração & dosagem
Seres Humanos
Ativação Linfocitária/efeitos dos fármacos
Metilprednisolona/administração & dosagem
Psoríase/diagnóstico
Psoríase/tratamento farmacológico
Psoríase/imunologia
Pele/imunologia
Pele/patologia
Linfócitos T Auxiliares-Indutores/efeitos dos fármacos
Linfócitos T Auxiliares-Indutores/imunologia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Glucocorticoids); 0 (Interleukin-23); 0 (Naphthalenes); 0 (betamethasone butyrate propionate); 9842X06Q6M (Betamethasone); G7RIW8S0XP (terbinafine); X4W7ZR7023 (Methylprednisolone)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE
[do] DOI:10.18176/jiaci.0116


  9 / 1887 MEDLINE  
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[PMID]:28204496
[Au] Autor:Fiete D; Mi Y; Beranek M; Baenziger NL; Baenziger JU
[Ad] Endereço:Departments of Biochemistry and Molecular Biophysics, and Neuroscience, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA.
[Ti] Título:The glycan-specific sulfotransferase (R77W)GalNAc-4-ST1 putatively responsible for peeling skin syndrome has normal properties consistent with a simple sequence polymorphisim.
[So] Source:Glycobiology;27(5):450-456, 2017 May 01.
[Is] ISSN:1460-2423
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Expanded access to DNA sequencing now fosters ready detection of site-specific human genome alterations whose actual significance requires in-depth functional study to rule in or out disease-causing mutations. This is a particular concern for genomic sequence differences in glycosyltransferases, whose implications are often difficult to assess. A recent whole-exome sequencing study identifies (c.229 C > T) in the GalNAc-4-ST1 glycosyltransferase (CHST8) as a disease-causing missense R77W mutation yielding the genodermatosis peeling skin syndrome (PSS) when homozygous. Cabral et al. (Genomics. 2012;99:202-208) cite this sequence change as reducing keratinocyte GalNAc-4-ST1 activity, thus decreasing glycosaminoglycan sulfation, as the mechanism for this blistering disorder. Such an identification could point toward potential clinical and/or prenatal diagnosis of a harmful medical condition. However, GalNAc-4-ST1 has minimal activity toward glycosaminoglycans, instead modifying terminal ß1,4-linked GalNAc on N- and O-linked oligosaccharides on specific glycoproteins. We find expression, processing and catalytic activity of GalNAc-4-ST1 completely equivalent between wild type and (R77W) sulfotransferases. Moreover, keratinocytes have little or no GalNAc-4-ST1 mRNA, indicating that they do not express GalNAc-4-ST1. In addition, loss-of-function of GalNAc-4-ST1 primarily presents as reproductive system aberrations rather than skin effects. These findings, an allele frequency of 0.004357, and a 10-fold difference in prevalence of CHST8 (c.299 C > T, R77W) across different ethnic groups, suggest that this sequence represents a "passenger" distributed polymorphism, a simple sequence variant form of the enzyme having normal activity, rather than a "driver" disease-causing mutation that accounts for PSS. This study presents an example for guiding biomedical research initiatives, as well as medical and personal/family perspectives, regarding newly-identified genomic sequence differences.
[Mh] Termos MeSH primário: Dermatite Esfoliativa/genética
Repetições de Microssatélites/genética
Polissacarídeos/genética
Dermatopatias Genéticas/genética
Sulfotransferases/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Células CHO
Clonagem Molecular
Cricetinae
Cricetulus
Dermatite Esfoliativa/enzimologia
Glicosaminoglicanos/genética
Glicosaminoglicanos/metabolismo
Seres Humanos
Mutação de Sentido Incorreto
Oligossacarídeos/genética
Oligossacarídeos/metabolismo
Polimorfismo Genético
Polissacarídeos/metabolismo
Dermatopatias Genéticas/enzimologia
Sulfotransferases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycosaminoglycans); 0 (Oligosaccharides); 0 (Polysaccharides); EC 2.8.2.- (N-acetylgalactosamine-4-sulfotransferase); EC 2.8.2.- (Sulfotransferases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE
[do] DOI:10.1093/glycob/cwx018


  10 / 1887 MEDLINE  
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[PMID]:28191631
[Au] Autor:Megna M; Sidikov AA; Zaslavsky DV; Chuprov IN; Timoshchuk EA; Egorova U; Wenzel J; Nasyrov RA
[Ad] Endereço:Department of Dermatology, University of Naples Federico II, Napoli, Italy.
[Ti] Título:The role of histological presentation in erythroderma.
[So] Source:Int J Dermatol;56(4):400-404, 2017 Apr.
[Is] ISSN:1365-4632
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Erythroderma is a serious medical condition characterized by inflamed red skin involving over 90% of the body. It can be the common presentation of different diseases, therefore clinical diagnosis can be problematic. Controversial data are reported regarding the diagnostic value of histological examination in erythroderma subjects. METHODS: A retrospective study was performed, investigating histological skin specimens of patients with a clinical diagnosis of erythroderma admitted to the Department of Dermatology of State Pediatric Medical University, Saint Petersburg, from 2001 to 2014. Histopathology examination was performed in each case by a pathologist with a special interest in the skin disease who was blind to any clinical information as well as to final diagnosis. RESULTS: Blinded histopathology examination alone was able to give the correct diagnosis in 61% (n = 50/82) of cases when compared to final diagnosis. A diagnosis of psoriasis was made in 23.2% (n = 19/82) of subjects, spongiotic dermatitis/eczema in 20.7% (n = 17/82), mycosis fungoides in 8.5% (n = 7/82), and drug eruption in 8.5%; histological diagnosis was inconclusive or not matching the final diagnosis when available in the remaining 39.1% of cases (n = 32/82). CONCLUSION: Erythroderma remains a condition difficult to study and treat. We showed that a correct judgment about its cause can be based on objective histopathological criteria in up to 60% of cases. More studies are needed to try to find out further histological and/or immunohistochemical markers that could help the clinician with the erythroderma etiology diagnostic process.
[Mh] Termos MeSH primário: Dermatite Esfoliativa/diagnóstico
Dermatite Esfoliativa/patologia
Erupção por Droga/diagnóstico
Eczema/diagnóstico
Micose Fungoide/diagnóstico
Psoríase/diagnóstico
Neoplasias Cutâneas/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Diagnóstico Diferencial
Erupção por Droga/patologia
Eczema/patologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Micose Fungoide/patologia
Psoríase/patologia
Estudos Retrospectivos
Neoplasias Cutâneas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170214
[St] Status:MEDLINE
[do] DOI:10.1111/ijd.13488



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