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Pesquisa : C17.800.329.937.122 [Categoria DeCS]
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[PMID]:29254313
[Au] Autor:Goren A; Naccarato T; Situm M; Kovacevic M; Lotti T; McCoy J
[Ad] Endereço:Applied Biology, Inc., Irvine, CA, USA.
[Ti] Título:Mechanism of action of minoxidil in the treatment of androgenetic alopecia is likely mediated by mitochondrial adenosine triphosphate synthase-induced stem cell differentiation.
[So] Source:J Biol Regul Homeost Agents;31(4):1049-1053, 2017 Oct-Dec.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Topical minoxidil is the only topical drug approved by the US Food and Drug Administration (FDA) for the treatment of androgenetic alopecia. However, the exact mechanism by which minoxidil stimulates anagen phase and promotes hair growth is not fully understood. In the late telegen phase of the hair follicle growth cycle, stem cells located in the bulge region differentiate and re-enter anagen phase, a period of growth lasting 2-6 years. In androgenetic alopecia, the anagen phase is shortened and a progressive miniaturization of hair follicles occurs, eventually leading to hair loss. Several studies have demonstrated that minoxidil increases the amount of intracellular Ca2+, which has been shown to up-regulate the enzyme adenosine triphosphate (ATP) synthase. A recent study demonstrated that ATP synthase, independent of its role in ATP synthesis, promotes stem cell differentiation. As such, we propose that minoxidil induced Ca2+ influx can increase stem cell differentiation and may be a key factor in the mechanism by which minoxidil facilitates hair growth. Based on our theory, we provide a roadmap for the development of a new class of drugs for the treatment of androgenetic alopecia.
[Mh] Termos MeSH primário: Alopecia/tratamento farmacológico
Folículo Piloso/efeitos dos fármacos
Minoxidil/uso terapêutico
Mitocôndrias/efeitos dos fármacos
ATPases Mitocondriais Próton-Translocadoras/genética
Células-Tronco/efeitos dos fármacos
Vasodilatadores/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Alopecia/enzimologia
Alopecia/genética
Alopecia/patologia
Cálcio/metabolismo
Diferenciação Celular/efeitos dos fármacos
Expressão Gênica
Folículo Piloso/enzimologia
Folículo Piloso/patologia
Seres Humanos
Transporte de Íons/efeitos dos fármacos
Masculino
Meia-Idade
Mitocôndrias/enzimologia
ATPases Mitocondriais Próton-Translocadoras/metabolismo
Células-Tronco/enzimologia
Células-Tronco/patologia
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vasodilator Agents); 5965120SH1 (Minoxidil); EC 3.6.3.- (Mitochondrial Proton-Translocating ATPases); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


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[PMID]:29254307
[Au] Autor:Goren A; Shapiro J; Naccarato T; Situm M; Kovacevic M; Lonky N; Lotti T; McCoy J
[Ad] Endereço:Applied Biology, Inc., Irvine, CA, USA.
[Ti] Título:Social selection favours offspring prone to the development of androgenetic alopecia.
[So] Source:J Biol Regul Homeost Agents;31(4):1013-1016, 2017 Oct-Dec.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:In recent years, dermatologists have observed an increase in the incidence of male androgenetic alopecia (AGA). In a survey of 41 dermatologists, 88% reported an increase in incidence of AGA in men younger than 30 years. This phenomenon has no apparent explanation. However, due to the strong genetic inheritance component of AGA, a social or environmental factor which favours the inheritance of genes that increase the risk of developing AGA is suspected. To date, the strongest predictor of AGA in men has been the length of the CAG repeat located in the androgen receptor gene (AR gene) on the X chromosome. The same genetic variant in women is associated with ovulation at a later age, higher antral follicle count, and lower risk for premature ovarian failure. This led us to theorize that, due to social pressure to conceive later in life, women carriers of the short CAG repeat in the AR gene would have a selective advantage to conceive later in life and would thus favour male offspring exhibiting AGA.
[Mh] Termos MeSH primário: Alopecia/genética
Predisposição Genética para Doença
Herança Materna
Receptores Androgênicos/genética
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Alopecia/diagnóstico
Cromossomos Humanos X/química
Cromossomos Humanos X/metabolismo
Feminino
Fertilização/genética
Expressão Gênica
Seres Humanos
Masculino
Folículo Ovariano/citologia
Folículo Ovariano/fisiologia
Ovulação/genética
Receptores Androgênicos/química
Seleção Genética
Fatores Socioeconômicos
Repetições de Trinucleotídeos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Androgen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


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[PMID]:29331373
[Au] Autor:Kwack MH; Yang JM; Won GH; Kim MK; Kim JC; Sung YK
[Ad] Endereço:Department of Immunology, School of Medicine, Kyungpook National University, Daegu, South Korea.
[Ti] Título:Establishment and characterization of five immortalized human scalp dermal papilla cell lines.
[So] Source:Biochem Biophys Res Commun;496(2):346-351, 2018 02 05.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dermal papilla (DP) regulates the growth and cycling of hair follicles. Cultured DP cells are useful for the study of their role in relation to hair growth and regeneration. However, cultivation of human DP cells is tedious and difficult. In addition, cultured DP cells possess a relatively short replicative life span, requiring immortalized human DP cell lines. We previously established an immortalized human DP cell line, SV40T-hTERT-DPC, by introducing human telomerase reverse transcriptase (hTERT) gene into the transformed cell line, SV40T-DPC. In this study, we co-transfected the simian virus 40 large T antigen (SV40T-Ag) and hTERT into DP cells from scalp hair follicles from a male with androgenetic alopecia and established five immortalized DP cell lines and named KNU-101, KNU-102, KNU-103, KNU-201 and KNU-202. We then evaluated tumorigenicity, expression of DP markers, responses to androgen, Wnt3a and BMP4, and expression of DP signature genes. These cell lines displayed early passage morphology and maintained responses to androgen, Wnt and BMP. Furthermore, these cell lines expressed DP markers and DP signature genes. KNU cell lines established in this study are potentially useful sources for hair research.
[Mh] Termos MeSH primário: Alopecia/genética
Derme/metabolismo
Efeito Fundador
Folículo Piloso/metabolismo
[Mh] Termos MeSH secundário: Células A549
Alopecia/metabolismo
Alopecia/patologia
Animais
Biglicano/genética
Biglicano/metabolismo
Biomarcadores/metabolismo
Proteína Morfogenética Óssea 4/farmacologia
Carcinogênese/genética
Carcinogênese/metabolismo
Carcinogênese/patologia
Linhagem Celular Transformada
Derme/patologia
Di-Hidrotestosterona/farmacologia
Feminino
Expressão Gênica
Folículo Piloso/efeitos dos fármacos
Folículo Piloso/patologia
Seres Humanos
Queratina-8/genética
Queratina-8/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Nus
Receptores Androgênicos/genética
Receptores Androgênicos/metabolismo
Couro Cabeludo/metabolismo
Couro Cabeludo/patologia
Versicanas/genética
Versicanas/metabolismo
Proteína Wnt3A/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (BGN protein, human); 0 (BMP4 protein, human); 0 (Biglycan); 0 (Biomarkers); 0 (Bone Morphogenetic Protein 4); 0 (KRT8 protein, human); 0 (Keratin-8); 0 (Receptors, Androgen); 0 (VCAN protein, human); 0 (WNT3A protein, human); 0 (Wnt3A Protein); 08J2K08A3Y (Dihydrotestosterone); 126968-45-4 (Versicans)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180115
[St] Status:MEDLINE


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[PMID]:29367355
[Au] Autor:Salam A; Tziotzios C; Fenton DA
[Ad] Endereço:St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital, London SE1 9RT, UK.
[Ti] Título:Hair loss is an important symptom of the menopause.
[So] Source:BMJ;360:k245, 2018 01 24.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Alopecia
Menopausa
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.k245


  5 / 8856 MEDLINE  
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[PMID]:27778425
[Au] Autor:Admani S; Goldenberg A; Jacob SE
[Ad] Endereço:Department of Dermatology, University of California, San Diego, La Jolla, California.
[Ti] Título:Contact Alopecia: Improvement of Alopecia with Discontinuation of Fluocinolone Oil in Individuals Allergic to Balsam Fragrance.
[So] Source:Pediatr Dermatol;34(1):e57-e60, 2017 Jan.
[Is] ISSN:1525-1470
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Inflammatory scalp dermatoses can be associated with alopecia, which is nonscarring and reversible in its early stages. This association has been described in seborrheic dermatitis, psoriasis, and atopic dermatitis. We describe three girls with alopecia aggravated by contact allergy to balsam fragrances. All three had complete resolution with avoidance of balsam of Peru and other balsam derivatives (including discontinuation of fluocinolone oil, which contains balsam of pine).
[Mh] Termos MeSH primário: Alérgenos/efeitos adversos
Alopecia/induzido quimicamente
Bálsamos/efeitos adversos
Dermatite Alérgica de Contato/etiologia
Perfumes/efeitos adversos
[Mh] Termos MeSH secundário: Adolescente
Alopecia/diagnóstico
Pré-Escolar
Dermatite Alérgica de Contato/diagnóstico
Feminino
Seres Humanos
Testes do Emplastro
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Allergens); 0 (Balsams); 0 (Perfume); 8P5F881OCY (Peruvian balsam)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1111/pde.13011


  6 / 8856 MEDLINE  
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[PMID]:29186269
[Au] Autor:Ramos PM; Brianezi G; Martins ACP; Silva MGD; Marques MEA; Miot HA
[Ad] Endereço:Department of Dermatology and Radiotherapy - Faculdade de Medicina de Botucatu - Universidade Estadual Paulista "Júlio de Mesquita Filho" (FMB-UNESP) - Botucatu (SP), Brazil.
[Ti] Título:Aryl hydrocarbon receptor overexpression in miniaturized follicles in female pattern hair loss.
[So] Source:An Bras Dermatol;92(3):430-431, 2017 May-Jun.
[Is] ISSN:1806-4841
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The etiopathogenesis of female pattern hair loss is still poorly understood. In addition to genetic and hormonal elements, environmental factors could be involved. The aryl hydrocarbon receptor is expressed in keratinocytes and can be activated by environmental pollutants leading to alterations in the cell cycle, inflammation, and apoptosis. Here we demonstrate the overexpression of nuclear aryl hydrocarbon receptors in miniaturized hair follicles in female pattern hair loss.
[Mh] Termos MeSH primário: Alopecia/metabolismo
Folículo Piloso/metabolismo
Receptores de Hidrocarboneto Arílico/metabolismo
[Mh] Termos MeSH secundário: Alopecia/patologia
Feminino
Folículo Piloso/química
Folículo Piloso/patologia
Seres Humanos
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptors, Aryl Hydrocarbon)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE


  7 / 8856 MEDLINE  
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[PMID]:29065140
[Au] Autor:Brunner MAT; Jagannathan V; Waluk DP; Roosje P; Linek M; Panakova L; Leeb T; Wiener DJ; Welle MM
[Ad] Endereço:Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
[Ti] Título:Novel insights into the pathways regulating the canine hair cycle and their deregulation in alopecia X.
[So] Source:PLoS One;12(10):e0186469, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Alopecia X is a hair cycle arrest disorder in Pomeranians. Histologically, kenogen and telogen hair follicles predominate, whereas anagen follicles are sparse. The induction of anagen relies on the activation of hair follicle stem cells and their subsequent proliferation and differentiation. Stem cell function depends on finely tuned interactions of signaling molecules and transcription factors, which are not well defined in dogs. We performed transcriptome profiling on skin biopsies to analyze altered molecular pathways in alopecia X. Biopsies from five affected and four non-affected Pomeranians were investigated. Differential gene expression revealed a downregulation of key regulator genes of the Wnt (CTNNB1, LEF1, TCF3, WNT10B) and Shh (SHH, GLI1, SMO, PTCH2) pathways. In mice it has been shown that Wnt and Shh signaling results in stem cell activation and differentiation Thus our findings are in line with the lack of anagen hair follicles in dogs with Alopecia X. We also observed a significant downregulation of the stem cell markers SOX9, LHX2, LGR5, TCF7L1 and GLI1 whereas NFATc1, a quiescence marker, was upregulated in alopecia X. Moreover, genes coding for enzymes directly involved in the sex hormone metabolism (CYP1A1, CYP1B1, HSD17B14) were differentially regulated in alopecia X. These findings are in agreement with the so far proposed but not yet proven deregulation of the sex hormone metabolism in this disease.
[Mh] Termos MeSH primário: Alopecia/veterinária
Cabelo
[Mh] Termos MeSH secundário: Alopecia/genética
Animais
Biomarcadores/metabolismo
Cães
Feminino
Masculino
Receptores de Calcitriol/metabolismo
Células-Tronco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Receptors, Calcitriol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186469


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[PMID]:29064980
[Au] Autor:Avram MR; Finney R; Rogers N
[Ad] Endereço:*Private Practice, Dermatology, New York, New York; †Weill Cornell Medical Center, New York, New York; ‡Heights Dermatology, Brooklyn, New York; §Tulane Health Sciences Center, New Orleans, Louisiana; ‖Private Practice, Old Metairie Dermatology, Metairie, Louisiana.
[Ti] Título:Hair Transplantation Controversies.
[So] Source:Dermatol Surg;43 Suppl 2:S158-S162, 2017 Nov.
[Is] ISSN:1524-4725
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hair transplant surgery creates consistently natural appearing transplanted hair for men. It is increasingly popular procedure to restore natural growing hair for men with hair loss. OBJECTIVE: To review some current controversies in hair transplant surgery. MATERIALS AND METHODS: Review of the English PubMed literature and specialty literature in hair transplant surgery. RESULTS: Some of the controversies in hair transplant surgery include appropriate donor harvesting technique including elliptical donor harvesting versus follicular unit extraction whether manual versus robotic, the role of platelet-rich plasma and low-level light surgery in hair transplant surgery. CONCLUSION: Hair transplant surgery creates consistently natural appearing hair. As with all techniques, there are controversies regarding the optimal method for performing the procedure. Some of the current controversies in hair transplant surgery include optimal donor harvesting techniques, elliptical donor harvesting versus follicular unit extraction, the role of low-level light therapy and the platelet-rich plasma therapy in the procedure. Future studies will further clarify their role in the procedure.
[Mh] Termos MeSH primário: Alopecia/terapia
Técnicas Cosméticas
Folículo Piloso/transplante
[Mh] Termos MeSH secundário: Seres Humanos
Terapia a Laser
Masculino
Plasma Rico em Plaquetas
Coleta de Tecidos e Órgãos/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE
[do] DOI:10.1097/DSS.0000000000001316


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[PMID]:28971497
[Au] Autor:Zhou CK; Stanczyk FZ; Hafi M; Veneroso CC; Lynch B; Falk RT; Niwa S; Emanuel E; Gao YT; Hemstreet GP; Zolfghari L; Carroll PR; Manyak MJ; Sesterhenn IA; Levine PH; Hsing AW; Cook MB
[Ad] Endereço:Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
[Ti] Título:Circulating and intraprostatic sex steroid hormonal profiles in relation to male pattern baldness and chest hair density among men diagnosed with localized prostate cancers.
[So] Source:Prostate;77(16):1573-1582, 2017 Dec.
[Is] ISSN:1097-0045
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Prospective cohort studies of circulating sex steroid hormones and prostate cancer risk have not provided a consistent association, despite evidence from animal and clinical studies. However, studies using male pattern baldness as a proxy of early-life or cumulative androgen exposure have reported significant associations with aggressive and fatal prostate cancer risk. Given that androgens underlie the development of patterned hair loss and chest hair, we assessed whether these two dermatological characteristics were associated with circulating and intraprostatic concentrations of sex steroid hormones among men diagnosed with localized prostate cancer. METHODS: We included 248 prostate cancer patients from the NCI Prostate Tissue Study, who answered surveys and provided a pre-treatment blood sample as well as fresh frozen adjacent normal prostate tissue. Male pattern baldness and chest hair density were assessed by trained nurses before surgery. General linear models estimated geometric means and 95% confidence intervals (95%CIs) of each hormone variable by dermatological phenotype with adjustment for potential confounding variables. Subgroup analyses were performed by Gleason score (<7 vs ≥7) and race (European American vs. African American). RESULTS: We found strong positive associations of balding status with serum testosterone, dihydrotestosterone (DHT), estradiol, and sex hormone-binding globulin (SHBG), and a weak association with elevated intraprostatic testosterone. Conversely, neither circulating nor intraprostatic sex hormones were statistically significantly associated with chest hair density. Age-adjusted correlation between binary balding status and three-level chest hair density was weak (r = 0.05). There was little evidence to suggest that Gleason score or race modified these associations. CONCLUSIONS: This study provides evidence that balding status assessed at a mean age of 60 years may serve as a clinical marker for circulating sex hormone concentrations. The weak-to-null associations between balding status and intraprostatic sex hormones reaffirm differences in organ-specific sex hormone metabolism, implying that other sex steroid hormone-related factors (eg, androgen receptor) play important roles in organ-specific androgenic actions, and that other overlapping pathways may be involved in associations between the two complex conditions.
[Mh] Termos MeSH primário: Alopecia/sangue
Alopecia/diagnóstico
Hormônios Esteroides Gonadais/sangue
Folículo Piloso/metabolismo
Neoplasias da Próstata/sangue
Neoplasias da Próstata/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Alopecia/epidemiologia
Biomarcadores/sangue
Biomarcadores/metabolismo
Seguimentos
Hormônios Esteroides Gonadais/metabolismo
Cabelo/metabolismo
Seres Humanos
Masculino
Meia-Idade
Projetos Piloto
Neoplasias da Próstata/epidemiologia
Tórax/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Biomarkers); 0 (Gonadal Steroid Hormones)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.1002/pros.23433


  10 / 8856 MEDLINE  
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[PMID]:28967390
[Au] Autor:Kim D; Garza LA
[Ad] Endereço:Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
[Ti] Título:The Negative Regulator CXXC5: Making WNT Look a Little Less Dishevelled.
[So] Source:J Invest Dermatol;137(11):2248-2250, 2017 Nov.
[Is] ISSN:1523-1747
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Wingless-related integration site (WNT)/ß-catenin signaling regulates diverse physiological functions including tissue regeneration. Activation of WNT signaling can be inhibited by various agents. Lee et al. investigate the interaction of CXXC-type zinc finger protein 5 (CXXC5) with Dishevelled as one such negative regulator of WNT in hair follicle regeneration.
[Mh] Termos MeSH primário: Alopecia/genética
Proteínas de Transporte/genética
Folículo Piloso/fisiologia
Peptídeos e Proteínas de Sinalização Intracelular/genética
Ácido Valproico/farmacologia
Via de Sinalização Wnt/genética
[Mh] Termos MeSH secundário: Animais
Regulação da Expressão Gênica
Folículo Piloso/efeitos dos fármacos
Seres Humanos
Camundongos
Regeneração/genética
Sensibilidade e Especificidade
Transdução de Sinais
Proteínas Wnt/metabolismo
Via de Sinalização Wnt/efeitos dos fármacos
beta Catenina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CXXC5 protein, human); 0 (CXXC5 protein, mouse); 0 (Carrier Proteins); 0 (Intracellular Signaling Peptides and Proteins); 0 (Wnt Proteins); 0 (beta Catenin); 614OI1Z5WI (Valproic Acid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE



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