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  1 / 1842 MEDLINE  
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[PMID]:29261764
[Au] Autor:Leistner R; Kola A; Gastmeier P; Krüger R; Hoppe PA; Schneider-Burrus S; Zuschneid I; Wischnewski N; Bender J; Layer F; Niebank M; Scheibenbogen C; Hanitsch LG
[Ad] Endereço:Institute of Hygiene and Environmental Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.
[Ti] Título:Pyoderma outbreak among kindergarten families: Association with a Panton-Valentine leukocidin (PVL)-producing S. aureus strain.
[So] Source:PLoS One;12(12):e0189961, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: We report on an outbreak of skin and soft tissue infections (SSTI) among kindergarten families. We analyzed the transmission route and aimed to control the outbreak. METHODS: The transmission route was investigated by nasal screening for Panton-Valentine leukocidin (PVL)-producing Staphylococcus aureus (PVL-SA), subsequent microbiological investigation including whole genome sequencing and a questionnaire-based analysis of epidemiological information. The control measures included distribution of outbreak information to all individuals at risk and implementation of a Staphylococcus aureus decontamination protocol. RESULTS: Individuals from 7 of 19 families were either colonized or showed signs of SSTI such as massive abscesses or eye lid infections. We found 10 PVL-SA isolates in 9 individuals. In the WGS-analysis all isolates were found identical with a maximum of 17 allele difference. The clones were methicillin-susceptible but cotrimoxazole resistant. In comparison to PVL-SAs from an international strain collection, the outbreak clone showed close genetical relatedness to PVL-SAs from a non-European country. The questionnaire results showed frequent travels of one family to this area. The results also demonstrated likely transmission via direct contact between families. After initiation of Staphylococcus aureus decontamination no further case was detected. CONCLUSIONS: Our outbreak investigation showed the introduction of a PVL-SA strain into a kindergarten likely as a result of international travel and further transmission by direct contact. The implementation of a Staphylococcus aureus decontamination protocol was able to control the outbreak.
[Mh] Termos MeSH primário: Toxinas Bacterianas/biossíntese
Surtos de Doenças/estatística & dados numéricos
Exotoxinas/biossíntese
Leucocidinas/biossíntese
Pioderma/epidemiologia
Pioderma/microbiologia
Infecções Estafilocócicas/epidemiologia
Infecções Estafilocócicas/microbiologia
Staphylococcus aureus/fisiologia
[Mh] Termos MeSH secundário: Alelos
Pré-Escolar
Família
Seres Humanos
Funções Verossimilhança
Filogenia
Apoio Social
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Toxins); 0 (Exotoxins); 0 (Leukocidins); 0 (Panton-Valentine leukocidin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189961


  2 / 1842 MEDLINE  
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[PMID]:28562771
[Au] Autor:Eyer-Silva WA; Silva GARD; Ferry FRA; Pinto JFDC
[Ad] Endereço:Centro de Ciências Biológicas e da Saúde, Hospital Universitário Gaffrée e Guinle, Universidade Federal do Estado do Rio de Janeiro, RJ, Brasil.
[Ti] Título:Facial botryomycosis-like pyoderma in an HIV-infected patient: remission after initiation of darunavir and raltegravir.
[So] Source:Rev Soc Bras Med Trop;50(2):277-279, 2017 Mar-Apr.
[Is] ISSN:1678-9849
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Botryomycosis is an uncommon, chronic, suppurative, bacterial infection that primarily affects the skin and subcutaneous tissues. It has long been associated with defects of cellular immunity. We report a 28-year-old woman who presented with a chronic, ulcerated lesion with draining sinuses in the right malar region. Predisposing factors were HIV infection with poor immunological control, alcoholism, and a previous trauma to the right cheek. Several courses of antimicrobial therapy provided only partial and temporary remission. Complete clinical remission was only achieved 5 years later when a novel antiretroviral regimen composed of darunavir and raltegravir was initiated.
[Mh] Termos MeSH primário: Infecções Oportunistas Relacionadas com a AIDS/tratamento farmacológico
Botrytis/isolamento & purificação
Dermatomicoses/tratamento farmacológico
Dermatoses Faciais/tratamento farmacológico
Pioderma/tratamento farmacológico
[Mh] Termos MeSH secundário: Infecções Oportunistas Relacionadas com a AIDS/diagnóstico
Adulto
Fármacos Anti-HIV/uso terapêutico
Darunavir/uso terapêutico
Dermatomicoses/diagnóstico
Dermatoses Faciais/diagnóstico
Feminino
Seres Humanos
Pioderma/diagnóstico
Raltegravir Potássico/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Anti-HIV Agents); 43Y000U234 (Raltegravir Potassium); YO603Y8113 (Darunavir)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170705
[Lr] Data última revisão:
170705
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE


  3 / 1842 MEDLINE  
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[PMID]:28278252
[Au] Autor:Swe PM; Christian LD; Lu HC; Sriprakash KS; Fischer K
[Ad] Endereço:QIMR Berghofer Medical Research Institute, Infectious Diseases Department, Herston, Brisbane, Australia.
[Ti] Título:Complement inhibition by Sarcoptes scabiei protects Streptococcus pyogenes - An in vitro study to unravel the molecular mechanisms behind the poorly understood predilection of S. pyogenes to infect mite-induced skin lesions.
[So] Source:PLoS Negl Trop Dis;11(3):e0005437, 2017 Mar.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: On a global scale scabies is one of the most common dermatological conditions, imposing a considerable economic burden on individuals, communities and health systems. There is substantial epidemiological evidence that in tropical regions scabies is often causing pyoderma and subsequently serious illness due to invasion by opportunistic bacteria. The health burden due to complicated scabies causing cellulitis, bacteraemia and sepsis, heart and kidney diseases in resource-poor communities is extreme. Co-infections of group A streptococcus (GAS) and scabies mites is a common phenomenon in the tropics. Both pathogens produce multiple complement inhibitors to overcome the host innate defence. We investigated the relative role of classical (CP), lectin (LP) and alternative pathways (AP) towards a pyodermic GAS isolate 88/30 in the presence of a scabies mite complement inhibitor, SMSB4. METHODOLOGY/PRINCIPAL FINDINGS: Opsonophagocytosis assays in fresh blood showed baseline immunity towards GAS. The role of innate immunity was investigated by deposition of the first complement components of each pathway, specifically C1q, FB and MBL from normal human serum on GAS. C1q deposition was the highest followed by FB deposition while MBL deposition was undetectable, suggesting that CP and AP may be mainly activated by GAS. We confirmed this result using sera depleted of either C1q or FB, and serum deficient in MBL. Recombinant SMSB4 was produced and purified from Pichia pastoris. SMSB4 reduced the baseline immunity against GAS by decreasing the formation of CP- and AP-C3 convertases, subsequently affecting opsonisation and the release of anaphylatoxin. CONCLUSIONS/SIGNIFICANCE: Our results indicate that the complement-inhibitory function of SMSB4 promotes the survival of GAS in vitro and inferably in the microenvironment of the mite-infested skin. Understanding the tripartite interactions between host, parasite and microbial pathogens at a molecular level may serve as a basis to develop improved intervention strategies targeting scabies and associated bacterial infections.
[Mh] Termos MeSH primário: Inativadores do Complemento/metabolismo
Proteínas do Sistema Complemento/imunologia
Fatores Imunológicos/antagonistas & inibidores
Sarcoptes scabiei/metabolismo
Streptococcus pyogenes/crescimento & desenvolvimento
Streptococcus pyogenes/imunologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Viabilidade Microbiana
Proteínas Opsonizantes/metabolismo
Pioderma/etiologia
Escabiose/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Complement Inactivating Agents); 0 (Immunologic Factors); 0 (Opsonin Proteins); 9007-36-7 (Complement System Proteins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005437


  4 / 1842 MEDLINE  
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[PMID]:28121967
[Au] Autor:O'Sullivan L; Moreland NJ; Webb RH; Upton A; Wilson NJ
[Ad] Endereço:From the *Navilluso Medical, Kaitaia, New Zealand; †Maurice Wilkins Center, ‡Faculty of Medical Health Sciences, University of Auckland, New Zealand; §Green Lane Paediatric and Congenital Cardiac Services, Starship Children's Hospital, Auckland, New Zealand; and ¶Labtests Pathology, Auckland, New Zealand.
[Ti] Título:Acute Rheumatic Fever After Group A Streptococcus Pyoderma and Group G Streptococcus Pharyngitis.
[So] Source:Pediatr Infect Dis J;36(7):692-694, 2017 Jul.
[Is] ISSN:1532-0987
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A case of acute rheumatic fever (ARF) in an Indigenous Maori child in New Zealand after Group A Streptococcus pyoderma and Group G Streptococcus pharyngitis is reported. The case demonstrates that ARF can develop in the absence of GAS pharyngitis and highlights a need for further research into the role of pyoderma and non-Group A Streptococci infections in ARF pathogenesis.
[Mh] Termos MeSH primário: Faringite
Pioderma
Febre Reumática
Infecções Estreptocócicas
Streptococcus pyogenes
[Mh] Termos MeSH secundário: Criança
Seres Humanos
Masculino
Streptococcus pneumoniae
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE
[do] DOI:10.1097/INF.0000000000001558


  5 / 1842 MEDLINE  
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[PMID]:28025853
[Au] Autor:De Lucia M; Bardagi M; Fabbri E; Ferreira D; Ferrer L; Scarampella F; Zanna G; Fondati A
[Ad] Endereço:Clinica Veterinaria Privata San Marco, Via Sorio 114/C, 35141, Padova, Italy.
[Ti] Título:Rifampicin treatment of canine pyoderma due to multidrug-resistant meticillin-resistant staphylococci: a retrospective study of 32 cases.
[So] Source:Vet Dermatol;28(2):171-e36, 2017 Apr.
[Is] ISSN:1365-3164
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Rifampicin has received increased interest in veterinary dermatology because of its activity against multidrug-resistant meticillin-resistant staphylococci (MRS). There is limited knowledge about the efficacy and safety of rifampicin in dogs. HYPOTHESIS/OBJECTIVE: To provide information on response to treatment and adverse effects in dogs treated with rifampicin for multidrug-resistant MRS pyoderma. ANIMALS: Thirty two dogs treated with rifampicin for rifampicin-susceptible multidrug-resistant MRS pyoderma. METHODS: Retrospective review of medical records, including alanine aminotransferase (ALT) and alkaline phosphatase (ALP) serum activity levels and total bilirubin concentrations, obtained before and throughout the treatment, was performed. RESULTS: Oral rifampicin as sole systemic antimicrobial therapy (median dose 5 mg/kg twice daily) was effective in 71.88% of cases. Topical antimicrobials were used in most cases. Median duration of rifampicin treatment was five weeks for superficial pyoderma and four weeks for deep pyoderma. Gastrointestinal signs were reported in 15% of treated dogs. Statistically significant increases of ALT (P = 0.045) and ALP (P = 0.0002) values after 3-4 weeks of treatment was observed. The median increase was equal to 0.3 and ×1.5 the upper limit of the reference ranges for ALT and ALP, respectively. CONCLUSIONS/CLINICAL IMPORTANCE: Oral rifampicin combined with topical antimicrobials can be considered an effective therapeutic option for canine superficial and deep pyoderma caused by rifampicin-susceptible multidrug-resistant MRS. Liver enzyme induction might be the most important cause of ALT and ALP increase associated with rifampicin therapy in dogs.
[Mh] Termos MeSH primário: Doenças do Cão/tratamento farmacológico
Farmacorresistência Bacteriana Múltipla
Pioderma/veterinária
Rifampina/uso terapêutico
Infecções Estafilocócicas/veterinária
Staphylococcus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Oral
Administração Tópica
Animais
Antibacterianos/administração & dosagem
Antibacterianos/uso terapêutico
Doenças do Cão/microbiologia
Cães
Feminino
Masculino
Resistência a Meticilina
Pioderma/tratamento farmacológico
Estudos Retrospectivos
Infecções Estafilocócicas/tratamento farmacológico
Infecções Estafilocócicas/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); VJT6J7R4TR (Rifampin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161228
[St] Status:MEDLINE
[do] DOI:10.1111/vde.12404


  6 / 1842 MEDLINE  
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[PMID]:27891724
[Au] Autor:Bäumer W; Bizikova P; Jacob M; Linder KE
[Ad] Endereço:Department of Molecular Biomedical Sciences, College of Veterinary Medicine, NC State University, Raleigh, NC, USA.
[Ti] Título:Establishing a canine superficial pyoderma model.
[So] Source:J Appl Microbiol;122(2):331-337, 2017 Feb.
[Is] ISSN:1365-2672
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: Pyoderma, predominantly associated with Staphylococcus pseudintermedius, is a common skin infection of dogs that typically requires long-lasting treatments, complicated by increasing antimicrobial resistance. To investigate new treatment strategies, we aimed at establishing a dog model of pyoderma that closely mimics the natural disease. METHODS AND RESULTS: We inoculated six laboratory beagles with a methicillin-susceptible strain of S. pseudintermedius. One millilitre of approximately 10 , 10 , 10 CFU per ml was topically applied onto clipped and tape stripped area of dog skin, which was then treated with a dermaroller (microneedle size: 500 µm) immediately after administration. Dogs were monitored daily, suspect pustules were cultured for S. pseudintermedius and evaluated by cytological and histopathological methods. After 24 h, all dogs developed papules and pustules at all three bacterial inoculation sites, which worsened over the next 48 h. Cytological samples of all skin lesions revealed neutrophils with intracellular cocci. Histopathology confirmed subcorneal neutrophilic pustular dermatitis with intralesional cocci and acantholytic keratinocytes, consistent with superficial pyoderma. Staphylococcus pseudintermedius was isolated from pustules of all dogs and confirmed to be the inoculating strain. The results were replicated in all dogs after a wash out period of 6 weeks. CONCLUSIONS: These data demonstrate the feasibility of establishing a dog model of pyoderma. SIGNIFICANCE AND IMPACT OF THE STUDY: The new model can be used to evaluate novel prevention and treatment options for canine pyoderma.
[Mh] Termos MeSH primário: Modelos Animais de Doenças
Doenças do Cão/microbiologia
Pioderma/veterinária
Infecções Cutâneas Estafilocócicas/veterinária
Staphylococcus/fisiologia
[Mh] Termos MeSH secundário: Animais
Dermatite Atópica/complicações
Dermatite Atópica/veterinária
Doenças do Cão/patologia
Cães
Feminino
Masculino
Pioderma/microbiologia
Pioderma/patologia
Infecções Cutâneas Estafilocócicas/microbiologia
Infecções Cutâneas Estafilocócicas/patologia
Staphylococcus/classificação
Staphylococcus/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161129
[St] Status:MEDLINE
[do] DOI:10.1111/jam.13362


  7 / 1842 MEDLINE  
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[PMID]:27426474
[Au] Autor:Banovic F; Linder K; Olivry T
[Ad] Endereço:Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, 2200 College Station Road, Georgia, GA, 30605, USA.
[Ti] Título:Clinical, microscopic and microbial characterization of exfoliative superficial pyoderma-associated epidermal collarettes in dogs.
[So] Source:Vet Dermatol;28(1):107-e23, 2017 Feb.
[Is] ISSN:1365-3164
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The microscopic and microbial features of the spreading epidermal collarettes of canine exfoliative superficial pyodermas are poorly characterized. OBJECTIVES: To characterize the clinical, cytological, microbial and histopathological features of epidermal collarettes in five dogs. RESULTS: Cytology from the margins of collarettes identified neutrophils, extracellular and intracellular cocci within neutrophils but no acantholytic keratinocytes. Phenotypic and genotypic analyses identified all bacterial isolates from the centre and margin of five epidermal collarettes as Staphylococcus pseudintermedius. PCRs of collarette-associated Staphylococcus strains did not amplify genes encoding for the known exfoliative toxins expA and expB, whereas the predicted siet and speta amplification products were detected in all isolates. Microscopically, epidermal collarettes consisted of interfollicular, epidermal spongiotic pustules. Advancing edges of lesions consisted of peripheral intracorneal clefts in the deep stratum disjunctum above an intact stratum compactum; they contained lytic neutrophil debris, bacterial cocci and fluid, but no acantholytic keratinocytes. This intracorneal location of bacteria was confirmed using Gram stains and fluorescent in situ hybridization with eubacterial- and Staphylococcus-specific probes. The indirect immunofluorescence staining patterns of desmoglein-1, desmocollin-1, claudin-1, E-cadherin and corneodesmosin were discontinuous and patchy in areas of spongiotic pustules, whereas only that of corneodesmosin was weaker and patchy in advancing collarette edges. CONCLUSION: Epidermal collarettes represent unique clinical and histological lesions of exfoliative superficial pyodermas that are distinct from those of impetigo and superficial bacterial folliculitis. The characterization of possible causative staphylococcal exfoliatin proteases and the role of corneodesmosin in collarette pathogenesis deserve further investigation.
[Mh] Termos MeSH primário: Doenças do Cão/patologia
Pioderma/veterinária
Infecções Cutâneas Estafilocócicas/veterinária
[Mh] Termos MeSH secundário: Animais
Doenças do Cão/diagnóstico
Doenças do Cão/microbiologia
Cães
Exotoxinas/genética
Hibridização in Situ Fluorescente/veterinária
Masculino
Pioderma/diagnóstico
Pioderma/microbiologia
Pioderma/patologia
Pele/microbiologia
Pele/patologia
Infecções Cutâneas Estafilocócicas/diagnóstico
Infecções Cutâneas Estafilocócicas/microbiologia
Infecções Cutâneas Estafilocócicas/patologia
Staphylococcus/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Exotoxins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160719
[St] Status:MEDLINE
[do] DOI:10.1111/vde.12352


  8 / 1842 MEDLINE  
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[PMID]:28027314
[Au] Autor:Pandey M; Ozberk V; Calcutt A; Langshaw E; Powell J; Rivera-Hernandez T; Ho MF; Philips Z; Batzloff MR; Good MF
[Ad] Endereço:Institute for Glycomics, Gold Coast Campus, Griffith University, Brisbane, Queensland, Australia.
[Ti] Título:Streptococcal Immunity Is Constrained by Lack of Immunological Memory following a Single Episode of Pyoderma.
[So] Source:PLoS Pathog;12(12):e1006122, 2016 Dec.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The immunobiology underlying the slow acquisition of skin immunity to group A streptococci (GAS), is not understood, but attributed to specific virulence factors impeding innate immunity and significant antigenic diversity of the type-specific M-protein, hindering acquired immunity. We used a number of epidemiologically distinct GAS strains to model the development of acquired immunity. We show that infection leads to antibody responses to the serotype-specific determinants on the M-protein and profound protective immunity; however, memory B cells do not develop and immunity is rapidly lost. Furthermore, antibodies do not develop to a conserved M-protein epitope that is able to induce immunity following vaccination. However, if re-infected with the same strain within three weeks, enduring immunity and memory B-cells (MBCs) to type-specific epitopes do develop. Such MBCs can adoptively transfer protection to naïve recipients. Thus, highly protective M-protein-specific MBCs may never develop following a single episode of pyoderma, contributing to the slow acquisition of immunity and to streptococcal endemicity in at-risk populations.
[Mh] Termos MeSH primário: Memória Imunológica/imunologia
Pioderma/imunologia
Pioderma/microbiologia
Infecções Estreptocócicas/imunologia
Infecções Estreptocócicas/microbiologia
[Mh] Termos MeSH secundário: Animais
Ensaio de Imunoadsorção Enzimática
Camundongos
Streptococcus pyogenes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161228
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006122


  9 / 1842 MEDLINE  
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[PMID]:27973532
[Au] Autor:Nordgren H; Aaltonen K; Raunio-Saarnisto M; Sukura A; Vapalahti O; Sironen T
[Ad] Endereço:FFBA Finnish Fur Breeders Association, Vantaa, Finland.
[Ti] Título:Experimental Infection of Mink Enforces the Role of Arcanobacterium phocae as Causative Agent of Fur Animal Epidemic Necrotic Pyoderma (FENP).
[So] Source:PLoS One;11(12):e0168129, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fur Animal Epidemic Necrotic Pyoderma (FENP) is a severe, often lethal infectious disease affecting all three fur animal species: mink (Neovision vision), foxes (Vulpes lagopus) and finnraccoons (Nyctereutes procyonoides). Previous studies showed an association between Arcanobacterium phocae and FENP. An experimental infection was conducted to confirm the ability of A. phocae to infect mink either alone or concurrently with a novel Streptococcus sp. found together with A. phocae in many cases of FENP. Different inoculation methods were tested to study possible routes of transmission. Typical signs, and gross- and histopathological findings for FENP were detected when naïve mink were infected with the tissue extract of mink with FENP, using a subcutaneous/ intradermal infection route. Edema, hemorrhage, necrosis and pus formation were detected in the infection site. A pure culture preparation of A. phocae alone or concurrently with the novel Streptococcus sp. caused severe acute signs of lethargy, apathy and anorexia and even mortality. The histopathological findings were similar to those found in naturally occurring cases of FENP. In contrast, the perorally infected mink presented no clinical signs nor any gross- or histopathological lesions. This study showed that A. phocae is able to cause FENP. The study also indicated that predisposing factors such as the environment, the general condition of the animals, temperature and skin trauma contribute to the development of the disease.
[Mh] Termos MeSH primário: Arcanobacterium
Vison/microbiologia
Necrose/microbiologia
Necrose/veterinária
Pioderma/microbiologia
Pioderma/veterinária
[Mh] Termos MeSH secundário: Animais
Edema
Meio Ambiente
Raposas
Hemorragia
Necrose/etiologia
Projetos Piloto
Reação em Cadeia da Polimerase
Pioderma/etiologia
Cães Guaxinins
Guaxinins
Pele/microbiologia
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161216
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0168129


  10 / 1842 MEDLINE  
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[PMID]:27790678
[Au] Autor:Schreml S
[Ad] Endereço:Department of Dermatology, University Medical Centre Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany. stephan@schreml.de.
[Ti] Título:The autoinflammatory pyoderma/acne (PA) syndromes: just interleukin-1-diseases?
[So] Source:Br J Dermatol;175(5):858, 2016 11.
[Is] ISSN:1365-2133
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Acne Vulgar
Interleucina-1
[Mh] Termos MeSH secundário: Seres Humanos
Pioderma
Pioderma Gangrenoso
Síndrome
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Nm] Nome de substância:
0 (Interleukin-1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE
[do] DOI:10.1111/bjd.14830



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