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[PMID]:29091565
[Au] Autor:van Zuuren EJ
[Ad] Endereço:From the Department of Dermatology, Leiden University Medical Center, Leiden, the Netherlands.
[Ti] Título:Rosacea.
[So] Source:N Engl J Med;377(18):1754-1764, 2017 Nov 02.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Rosácea/terapia
[Mh] Termos MeSH secundário: Administração Tópica
Adulto
Antibacterianos/uso terapêutico
Anti-Hipertensivos/uso terapêutico
Fármacos Dermatológicos/uso terapêutico
Feminino
Seres Humanos
Masculino
Fenótipo
Fototerapia
Guias de Prática Clínica como Assunto
Rinofima
Rosácea/classificação
Rosácea/tratamento farmacológico
Protetores Solares/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antihypertensive Agents); 0 (Dermatologic Agents); 0 (Sunscreening Agents)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171102
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMcp1506630


  2 / 2199 MEDLINE  
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[PMID]:28968402
[Au] Autor:Chiu HY; Huang WY; Ho CH; Wang JJ; Lin SJ; Hsu YW; Chen PJ
[Ad] Endereço:Institute of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, Taipei, Taiwan.
[Ti] Título:Increased risk of chronic kidney disease in patients with rosacea: A nationwide population-based matched cohort study.
[So] Source:PLoS One;12(10):e0180446, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Rosacea is a chronic inflammatory skin disorder. Inflammation and oxidative stress are involved in the etiopathogenesis of rosacea and chronic kidney disease (CKD). This study aimed to investigate the association between rosacea and CKD. METHODS: This population-based cohort study identified 277 patients with rosacea in the Taiwan National Health Insurance Research Database during 2001-2005. These patients were matched for age, sex, and comorbidities with 2216 patients without rosacea. All subjects were individually followed-up for 8-12 years to identify those who subsequently developed CKD. RESULTS: The incidence rates of CKD per 1000 person-years were 16.02 in patients with rosacea and 10.63 in the non-rosacea reference population. After adjusting for other covariates and considering the competing risk of mortality, patients with rosacea remained at increased risk of CKD (adjusted sub-distribution hazard ratio (aSD-HR) 2.00; 95% confidence interval (CI) 1.05-3.82). The aSD-HRs (95% CI) for CKD were 1.82 (0.83-4.00) and 2.53 (1.11-5.75) for patients with mild and moderate-to-severe rosacea, respectively. CONCLUSIONS: Rosacea is an independent risk factor for CKD. High rosacea severity and old age further increased CKD risk in patients with rosacea. Careful monitoring for CKD development should be included as part of integrated care for patients with rosacea.
[Mh] Termos MeSH primário: Falência Renal Crônica/complicações
Vigilância da População
Rosácea/complicações
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Fatores de Risco
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180446


  3 / 2199 MEDLINE  
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[PMID]:28837365
[Au] Autor:Patel NU; Shukla S; Zaki J; Feldman SR
[Ad] Endereço:a Center for Dermatology Research, Department of Dermatology , Wake Forest School of Medicine , Winston-Salem , NC , USA.
[Ti] Título:Oxymetazoline hydrochloride cream for facial erythema associated with rosacea.
[So] Source:Expert Rev Clin Pharmacol;10(10):1049-1054, 2017 Oct.
[Is] ISSN:1751-2441
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Rosacea is a chronic skin condition characterized by transient and persistent erythema of the central face. The symptom of persistent erythema can be particularly frustrating for both patients and physicians as it is difficult to treat. Areas covered: Current treatment options for the treatment of rosacea include metronidazole, azelaic acid, sodium sulfacetamide-sulfur, and brimonidine. Until recently, brimonidine gel was the only option approved specifically for the treatment of facial erythema. However, oxymetazoline hydrochloride 1% cream is a newly FDA approved topical medication for adult rosacea patients. A primarily alpha-1a agonist, oxymetazoline hydrochloride (HCl) is thought to diminish erythema through vasoconstriction. Our paper seeks to evaluate evidence for topical oxymetazoline HCl with respect to its efficacy and safety for its approved indication of treating the persistent erythema associated with rosacea. Expert commentary: While assessment of available clinical trial data indicates that the medication is as effective as other available treatment for controlling rosacea-associated erythema with minimal risk of adverse effects, studies of long-term duration and direct comparison will be necessary to establish its place in treatment guidelines and clinical practice. As further evidence becomes available, the real-world clinical potential of topical oxymetazoline cream will become clearer.
[Mh] Termos MeSH primário: Eritema/tratamento farmacológico
Oximetazolina/administração & dosagem
Rosácea/tratamento farmacológico
[Mh] Termos MeSH secundário: Administração Cutânea
Agonistas alfa-Adrenérgicos/administração & dosagem
Agonistas alfa-Adrenérgicos/efeitos adversos
Agonistas alfa-Adrenérgicos/farmacologia
Fármacos Dermatológicos/administração & dosagem
Fármacos Dermatológicos/efeitos adversos
Fármacos Dermatológicos/farmacologia
Eritema/etiologia
Eritema/patologia
Seres Humanos
Oximetazolina/efeitos adversos
Oximetazolina/farmacologia
Rosácea/patologia
Creme para a Pele
Vasoconstrição/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Adrenergic alpha-Agonists); 0 (Dermatologic Agents); 8VLN5B44ZY (Oxymetazoline)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE
[do] DOI:10.1080/17512433.2017.1370370


  4 / 2199 MEDLINE  
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[PMID]:28711190
[Au] Autor:Chang YS; Huang YC
[Ad] Endereço:Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan.
[Ti] Título:Role of Demodex mite infestation in rosacea: A systematic review and meta-analysis.
[So] Source:J Am Acad Dermatol;77(3):441-447.e6, 2017 Sep.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The reported prevalence and degrees of Demodex mite infestation in rosacea vary widely. OBJECTIVE: We sought to conduct an evidence-based meta-analysis of the prevalence and degrees of Demodex mite infestation in patients with rosacea. METHODS: Systematic literature review and meta-analysis were conducted. Odds ratios for prevalence of infestation and standardized mean difference (SMD) for Demodex density in patients with rosacea were pooled. Subgroup analysis for type of rosacea, control group, and sampling and examination methods were also performed. RESULTS: Twenty-three case-control studies included 1513 patients with rosacea. Compared with the control patients, patients with rosacea were more likely to be infested by Demodex mites [odds ratio, 9.039; 95% confidence interval (CI), 4.827-16.925] and had significantly higher Demodex density (SMD, 1.617; 95% CI, 1.090-2.145). Both erythematotelangiectatic rosacea (SMD, 2.686; 95% CI, 1.256-4.116) and papulopustular rosacea (SMD, 2.804; 95% CI, 1.464-4.145) had significantly higher Demodex density than did healthy control patients. LIMITATIONS: Interstudy variability was high, and a causal relationship could not be established by case-control studies. CONCLUSIONS: Patients with rosacea had significantly higher prevalence and degrees of Demodex mite infestation than did control patients. Demodex mites may play a role in both erythematotelangiectatic rosacea and papulopustular rosacea.
[Mh] Termos MeSH primário: Infestações por Ácaros/complicações
Rosácea/parasitologia
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Seres Humanos
Infestações por Ácaros/epidemiologia
Prevalência
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170717
[St] Status:MEDLINE


  5 / 2199 MEDLINE  
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[PMID]:28659135
[Au] Autor:Zhang B; Pan F; Zhu K
[Ad] Endereço:Department of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 Qinchun Road East, Hangzhou, 310016, Zhejiang, People's Republic of China. zhangbei@srrsh.com.
[Ti] Título:Bilateral Morganella Morganii keratitis in a patient with facial topical corticosteroid-induced rosacea-like dermatitis: a case report.
[So] Source:BMC Ophthalmol;17(1):106, 2017 Jun 28.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Bilateral keratitis rarely occurs in individuals without predisposing factors. Here we describe the clinical course of a patient who developed a bilateral keratitis caused by Morganella. morganii which might be associated with long term using of topical corticosteroids-containing preparations on the face. CASE PRESENTATION: A 52-year-old female patient presented with marked bilateral corneal infiltration and hypopyon without any usual predisposing factors for bilateral infectious keratitis. There was diffuse erythema with itching on face before the onset of eye discomforts. Microbiological culture of materials from both corneas revealed significant growth of Morganella morganii. Topical corticosteroid-induced rosacea-like dermatitis was diagnosed by dermatologist because of the characteristic eruptions and long history of using the corticosteroids-containing cosmetic creams on her face. The corneal ulcers responded well to levofloxacin eye drops and ofloxacin ointment and healed with opacity and neovascularization. CONCLUSION: This case illustrates that bilateral bacterial corneal infection can develop in patients with long term using of topical corticosteroids-containing preparations on the face. To our knowledge, this is the first case of bilateral keratitis caused by Morganella morganii.
[Mh] Termos MeSH primário: Infecções por Enterobacteriaceae/microbiologia
Infecções Oculares Bacterianas/microbiologia
Dermatoses Faciais/induzido quimicamente
Glucocorticoides/efeitos adversos
Ceratite/microbiologia
Morganella morganii/isolamento & purificação
Rosácea/induzido quimicamente
[Mh] Termos MeSH secundário: Córnea/microbiologia
Córnea/patologia
Diagnóstico Diferencial
Infecções por Enterobacteriaceae/complicações
Infecções por Enterobacteriaceae/diagnóstico
Infecções Oculares Bacterianas/complicações
Infecções Oculares Bacterianas/diagnóstico
Dermatoses Faciais/diagnóstico
Feminino
Seres Humanos
Ceratite/complicações
Ceratite/diagnóstico
Meia-Idade
Rosácea/complicações
Rosácea/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-017-0504-5


  6 / 2199 MEDLINE  
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[PMID]:28651825
[Au] Autor:Zhang M; Silverberg JI; Kaffenberger BH
[Ad] Endereço:Department of Internal Medicine, Division of Dermatology, The Ohio State University Wexner Medical Center, Columbus, Ohio.
[Ti] Título:Prescription patterns and costs of acne/rosacea medications in Medicare patients vary by prescriber specialty.
[So] Source:J Am Acad Dermatol;77(3):448-455.e2, 2017 Sep.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Prescription patterns for acne/rosacea medications have not been described in the Medicare population, and comparisons across specialties are lacking. OBJECTIVE: To describe the medications used for treating acne/rosacea in the Medicare population and evaluate differences in costs between specialties. METHODS: A cross-sectional study was performed of the 2008 and 2010 Centers for Medicare and Medicaid Services Prescription Drug Profiles, which contains 100% of Medicare part D claims. RESULTS: Topical antibiotics accounted for 63% of all prescriptions. Patients ≥65 years utilized more oral tetracycline-class antibiotics and less topical retinoids. Specialists prescribed brand name drugs for the most common topical retinoids and most common topical antibiotics more frequently than family medicine/internal medicine (FM/IM) physicians by 6%-7%. Topical retinoids prescribed by specialists were, on average, $18-$20 more in total cost and $2-$3 more in patient cost than the same types of prescriptions from FM/IM physicians per 30-day supply. Specialists (60%) and IM physicians (56%) prescribed over twice the rate of branded doxycycline than FM doctors did (27%). The total and patient costs for tetracycline-class antibiotics were higher from specialists ($18 and $4 more, respectively) and IM physicians ($3 and $1 more, respectively) than they were from FM physicians. LIMITATIONS: The data might contain rare prescriptions used for conditions other than acne/rosacea, and suppression algorithms might underestimate the number of specialist brand name prescriptions. CONCLUSION: Costs of prescriptions for acne/rosacea from specialists are higher than those from primary care physicians and could be reduced by choosing generic and less expensive options.
[Mh] Termos MeSH primário: Acne Vulgar/tratamento farmacológico
Antibacterianos/economia
Antibacterianos/uso terapêutico
Custos de Medicamentos
Padrões de Prática Médica
Retinoides/economia
Retinoides/uso terapêutico
Rosácea/tratamento farmacológico
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Estudos Transversais
Prescrições de Medicamentos/economia
Prescrições de Medicamentos/estatística & dados numéricos
Feminino
Seres Humanos
Masculino
Medicare
Medicina
Meia-Idade
Estados Unidos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Retinoids)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE


  7 / 2199 MEDLINE  
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[PMID]:28581215
[Au] Autor:Two AM
[Ad] Endereço:Department of Dermatology, University of California San Diego, 8899 University Center Lane, Suite 350, San Diego, CA, 92122, U.S.A.
[Ti] Título:Minocycline as an alternative to doxycycline in the treatment of rosacea.
[So] Source:Br J Dermatol;176(6):1426, 2017 06.
[Is] ISSN:1365-2133
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Doxiciclina
Minociclina
[Mh] Termos MeSH secundário: Antibacterianos
Seres Humanos
Rosácea
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); FYY3R43WGO (Minocycline); N12000U13O (Doxycycline)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE
[do] DOI:10.1111/bjd.15514


  8 / 2199 MEDLINE  
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[PMID]:28542720
[Au] Autor:Tan J; ROSCO coauthors
[Ad] Endereço:Department of Medicine, Western University, Windsor Campus, Windsor, ON, Canada.
[Ti] Título:Updating the diagnosis, classification and assessment of rosacea by effacement of subtypes: reply from the author.
[So] Source:Br J Dermatol;177(2):598-599, 2017 08.
[Is] ISSN:1365-2133
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Rosácea
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1111/bjd.15669


  9 / 2199 MEDLINE  
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[PMID]:28477357
[Au] Autor:Wilkin J
[Ti] Título:Updating the diagnosis, classification and assessment of rosacea by effacement of subtypes.
[So] Source:Br J Dermatol;177(2):597-598, 2017 08.
[Is] ISSN:1365-2133
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Rosácea
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE
[do] DOI:10.1111/bjd.15632


  10 / 2199 MEDLINE  
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[PMID]:28472572
[Au] Autor:Maor D; Chong AH
[Ti] Título:Rosacea.
[So] Source:Aust Fam Physician;46(5):277-281, 2017.
[Is] ISSN:0300-8495
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Rosacea is a chronic and common cutaneous condition characterised by symptoms of facial flushing and a broad spectrum of clinical signs. The clinical presentation for rosacea is varied, and there are four primary subtypes, which may overlap - erythrotelangiectatic, inflammatory, phymatous and ocular. It is important to recognise the different subtypes because of the differences in therapy. OBJECTIVE: The objective of this article is to provide evidence-based clinical updates to clinicians, specifically general practitioners (GPs), to assist with their everyday practice, and effective assessment and treatment of rosacea. DISCUSSION: Therapeutic modalities are chosen on the basis of the subtypes and clinical features identified; often a combination of these therapies is required.
[Mh] Termos MeSH primário: Rosácea/diagnóstico
Rosácea/fisiopatologia
Rosácea/terapia
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Antibacterianos/uso terapêutico
Tartarato de Brimonidina/farmacologia
Tartarato de Brimonidina/uso terapêutico
Diagnóstico Diferencial
Doxiciclina/farmacologia
Doxiciclina/uso terapêutico
Seres Humanos
Isotretinoína/farmacologia
Isotretinoína/uso terapêutico
Ivermectina/farmacologia
Ivermectina/uso terapêutico
Terapia a Laser/métodos
Metronidazol/farmacologia
Metronidazol/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 140QMO216E (Metronidazole); 4S9CL2DY2H (Brimonidine Tartrate); 70288-86-7 (Ivermectin); EH28UP18IF (Isotretinoin); N12000U13O (Doxycycline)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE



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