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[PMID]:29301743
[Au] Autor:Dowlatshahi EA; Diercks G; van Doorn M
[Ad] Endereço:Erasmus Medical Centre, Rotterdam, Netherlands emmilia.dowlat@gmail.com.
[Ti] Título:Blisters in disguise.
[So] Source:BMJ;360:j5364, 2018 01 04.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Vesícula/imunologia
Vesícula/patologia
Pênfigo/imunologia
Pênfigo/patologia
Pele/patologia
[Mh] Termos MeSH secundário: Corticosteroides/administração & dosagem
Corticosteroides/uso terapêutico
Idoso
Vesícula/tratamento farmacológico
Vesícula/epidemiologia
Desmogleínas/imunologia
Diagnóstico Diferencial
Ensaio de Imunoadsorção Enzimática/métodos
Técnica Direta de Fluorescência para Anticorpo/métodos
Seres Humanos
Fatores Imunológicos/administração & dosagem
Fatores Imunológicos/uso terapêutico
Imunossupressores/administração & dosagem
Imunossupressores/uso terapêutico
Incidência
Masculino
Pênfigo/tratamento farmacológico
Pênfigo/epidemiologia
Rituximab/administração & dosagem
Rituximab/uso terapêutico
Pele/imunologia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Desmogleins); 0 (Immunologic Factors); 0 (Immunosuppressive Agents); 4F4X42SYQ6 (Rituximab)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j5364


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[PMID]:29289926
[Au] Autor:Josse G; Douki T; Le Digabel J; Gravier E; Questel E
[Ad] Endereço:Centre de Recherche sur la Peau, Pierre Fabre Dermo-Cosmétique, F-31000 Toulouse, France. Electronic address: gwendal.josse@pierre-fabre.com.
[Ti] Título:The use of suction blisters to measure sunscreen protection against UVR-induced DNA damage.
[So] Source:J Photochem Photobiol B;179:1-6, 2018 Feb.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The formation of DNA photoproducts caused by solar UVR exposure needs to be investigated in-vivo and in particular in order to assess sunscreens' level of protection against solar genotoxicity. The study's purposes were: i) to evaluate if the roof of suction blisters is an appropriate sampling method for measuring photoproducts, and ii) to measure in-vivo sunscreen protection against cyclobutane pyrimidine dimers. Skin areas on the interior forearms of eight healthy volunteers were exposed in-vivo to 2 MED of simulated solar radiation (SSR) and to 15 MED on a sunscreen protected area. After irradiation, six suction blisters were induced and the blister roofs were collected. Analysis of SSR-induced CPDs was performed by two independent methods: a chromatography coupled to mass spectroscopy (HPLC-MS/MS) approach and a 3D-imaging of CPD immunostaining by multiphoton microscopy on floating epidermal sheets. HPLC-MS/MS analyses showed that SSR-unexposed skin presented no CPD dimers, whereas 2 MED SSR-exposed skin showed a significant number of TT-CPD. The sunscreen covered skin exposed to 15 MED appeared highly protected from DNA damage, as the amount of CPD-dimers remained below the detection limit. The multiphoton-immunostaining analysis consistently showed that no CPD staining was observed on the non-SSR-exposed skin. A significant increase of CPD staining intensity and number of CPD-positive cells were observed on the 2 MED SSR-exposed skin. Sunscreen protected skin presented a very low staining intensity and the number of CPD-positive cells remained very close to non-SSR-exposed skin. This study showed that suction blister samples are very appropriate for measuring CPD dimers in-vivo, and that sunscreens provide high protection against UVR-induced DNA damage.
[Mh] Termos MeSH primário: Dano ao DNA/efeitos dos fármacos
Pele/efeitos dos fármacos
Protetores Solares/farmacologia
Raios Ultravioleta
[Mh] Termos MeSH secundário: Adulto
Vesícula/genética
Vesícula/metabolismo
Vesícula/patologia
Cromatografia Líquida de Alta Pressão
Dano ao DNA/efeitos da radiação
Feminino
Seres Humanos
Masculino
Dímeros de Pirimidina/análise
Pele/efeitos da radiação
Fator de Proteção Solar
Espectrometria de Massas em Tandem
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pyrimidine Dimers); 0 (Sunscreening Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180101
[St] Status:MEDLINE


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[PMID]:29341574
[Au] Autor:Nagorni-Obradovic L; Pesut D; Maric D; Stevic R
[Ti] Título:Bullous lung diseases as a risk factor for lung cancer: A case report.
[So] Source:Vojnosanit Pregl;73(12):1160-3, 2016 Dec.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Introduction: A possible association between lung cancer and bullous lung disease has been suggested and recently supported by the results of genetic studies. Case report: A previously healthy 43-year-old man, smoker, was diagnosed with bullous lung disease at the age of 31 years. He was followed up for 12 years when lung cancer (adenocarcinoma) was found at the site. In the meantime, he was treated for recurrent respiratory infections. Conclusion: There is the need for active approach in following up the patients with pulmonary bulla for potential development of lung cancer.
[Mh] Termos MeSH primário: Adenocarcinoma/etiologia
Vesícula/complicações
Pneumopatias/complicações
Neoplasias Pulmonares/etiologia
[Mh] Termos MeSH secundário: Adenocarcinoma/diagnóstico por imagem
Adenocarcinoma/patologia
Adulto
Biópsia
Vesícula/diagnóstico por imagem
Broncoscopia
Progressão da Doença
Evolução Fatal
Seres Humanos
Pneumopatias/diagnóstico por imagem
Neoplasias Pulmonares/diagnóstico por imagem
Neoplasias Pulmonares/patologia
Masculino
Estadiamento de Neoplasias
Fatores de Risco
Fatores de Tempo
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150422077N


  4 / 4021 MEDLINE  
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[PMID]:28448670
[Au] Autor:Futakuchi A; Inoue T; Fujimoto T; Kuroda U; Inoue-Mochita M; Takahashi E; Ohira S; Tanihara H
[Ad] Endereço:Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
[Ti] Título:Molecular Mechanisms Underlying the Filtration Bleb-Maintaining Effects of Suberoylanilide Hydroxamic Acid (SAHA).
[So] Source:Invest Ophthalmol Vis Sci;58(4):2421-2429, 2017 04 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Suberoylanilide hydroxamic acid (SAHA) has been shown to support the maintenance of experimental filtration blebs in animal models. This study was performed to investigate the molecular mechanisms underlying the bleb-maintaining effects of SAHA in modulating wound healing activities of conjunctival fibroblasts. Methods: Human conjunctival fibroblasts (HConFs) were pretreated with SAHA before treatment with TGF-ß2. Microarray-based screening was used to investigate the gene expression profiles. Gene ontology (GO) analysis was conducted to categorize the gene functions. The expression of TGF-ß-induced signaling molecules, α-smooth muscle actin, and extracellular matrix (ECM) proteins were evaluated by Western blot analyses. Multiplex immunoassay was performed to evaluate supernatant cytokine concentrations. Tube formation assay was used to evaluate angiogenesis using human umbilical vein endothelial cells. Results: GO analysis showed that SAHA, in the presence of TGF-ß2, induced changes in expression of genes involved in the TGF-ß receptor signaling pathway, cell proliferation, extracellular matrix organization, inflammatory responses, and angiogenesis. Subsequent in vitro experiments showed that SAHA partly inhibited the phosphorylation of Smad2, Smad3, and Akt. SAHA pretreatment potently suppressed TGF-ß2-driven cell proliferation, myofibroblast differentiation, contraction, ECM production, and angiogenic cytokine expression. The supernatant of HConFs treated with SAHA inhibited tube formation. Conclusions: SAHA has been shown to suppress angiogenesis and activation of conjunctival fibroblasts partly via inhibition of Smad and non-Smad TGF-ß signaling. This in vitro study provides new evidence for the molecular basis of the potential bleb-maintaining effects of SAHA, a novel candidate drug in modulating scar formation after glaucoma filtration surgery.
[Mh] Termos MeSH primário: Inibidores da Angiogênese/farmacologia
Túnica Conjuntiva/efeitos dos fármacos
Fibroblastos/efeitos dos fármacos
Inibidores de Histona Desacetilases/farmacocinética
Ácidos Hidroxâmicos/farmacologia
[Mh] Termos MeSH secundário: Vesícula/metabolismo
Movimento Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Células Cultivadas
Colágeno Tipo I/metabolismo
Túnica Conjuntiva/citologia
Citocinas/metabolismo
Proteínas da Matriz Extracelular/metabolismo
Fibroblastos/metabolismo
Cirurgia Filtrante
Perfilação da Expressão Gênica
Seres Humanos
Receptores de Fatores de Crescimento Transformadores beta/metabolismo
Transdução de Sinais/efeitos dos fármacos
Proteínas Smad/metabolismo
Análise Serial de Tecidos
Fator de Crescimento Transformador beta2/farmacologia
Cicatrização/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (Collagen Type I); 0 (Cytokines); 0 (Extracellular Matrix Proteins); 0 (Histone Deacetylase Inhibitors); 0 (Hydroxamic Acids); 0 (Receptors, Transforming Growth Factor beta); 0 (Smad Proteins); 0 (Transforming Growth Factor beta2); 58IFB293JI (vorinostat)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-21403


  5 / 4021 MEDLINE  
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[PMID]:28452830
[Au] Autor:Janssen L; Allard NAE; Ten Haaf DSM; van Romburgh CPP; Eijsvogels TMH; Hopman MTE
[Ti] Título:First-Aid Treatment for Friction Blisters: "Walking Into the Right Direction?"
[So] Source:Clin J Sport Med;28(1):37-42, 2018 Jan.
[Is] ISSN:1536-3724
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Blisters are common foot injuries during and after prolonged walking. However, the best treatment remains unclear. The aim of the study was to compare the effect of 2 different friction blister treatment regimens, wide area fixation dressing versus adhesive tape. DESIGN: A prospective observational cohort study. SETTING: The 2015 Nijmegen Four Days Marches in the Netherlands. PARTICIPANTS: A total of 2907 participants (45 ± 16 years, 52% men) were included and received 4131 blister treatments. INTERVENTIONS: Blisters were treated with either a wide area fixation dressing or adhesive tape. MAIN OUTCOME MEASURES: Time of treatment application was our primary outcome. In addition, effectiveness and satisfaction were evaluated in a subgroup (n = 254). During a 1-month follow-up period, blister healing, infection and the need for additional medical treatment were assessed in the subgroup. RESULTS: Time of treatment application was lower (41.5 minutes; SD = 21.6 minutes) in the wide area fixation dressing group compared with the adhesive tape group (43.4 minutes; SD = 25.5 minutes; P = 0.02). Furthermore, the wide area fixation dressing group demonstrated a significantly higher drop-out rate (11.7% vs 4.0%, P = 0.048), delayed blister healing (51.9% vs 35.3%, P = 0.02), and a trend toward lower satisfaction (P = 0.054) when compared with the adhesive tape group. CONCLUSIONS: Wide area fixation dressing decreased time of treatment application by 2 minutes (4.5%) when compared with adhesive tape. However, because of lower effectiveness and a trend toward lower satisfaction, we do not recommend the use of wide area fixation dressing over adhesive tape in routine first-aid treatment for friction blisters.
[Mh] Termos MeSH primário: Fita Atlética
Bandagens
Vesícula/terapia
Traumatismos do Pé/terapia
[Mh] Termos MeSH secundário: Adulto
Feminino
Primeiros Socorros
Fricção
Seres Humanos
Masculino
Meia-Idade
Países Baixos
Estudos Prospectivos
Caminhada/lesões
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1097/JSM.0000000000000424


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[PMID]:28816934
[Au] Autor:Wan J; Zhang L; Lu G; Gu W; Huang L; Ge L; Zhang X; Ji L; Chen Q; Di R; Jiang Y
[Ad] Endereço:aDepartment of Interventional Radiology, Jing'an District Centre Hospital of Shanghai, Huashan Hospital Fudan University Jing'an Branch bDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
[Ti] Título:Midterm outcomes of intracranial aneurysms with bleb formation with densely coiling of the aneurismal neck or entire aneurysm.
[So] Source:Medicine (Baltimore);96(33):e7046, 2017 Aug.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To evaluate whether the efficacy and safety of embolization of the aneurysmal neck were better than those of embolization of the entire aneurysm. Previous studies found that embolization of the aneurysmal neck can be used for treating ruptured intracranial aneurysm with bleb formation.In all, 163 patients with ruptured aneurysms with bleb formation who underwent endovascular embolization at the Shanghai Municipal Jing'an District Central Hospital from January 2014 to August 2015 were divided into the embolization of aneurysmal neck group (neck group; 87 cases) and embolization of entire aneurysm group (aneurysm group; 76 cases). A retrospective analysis of clinical data, follow-up Glasgow Outcome Scale (GOS) score, and occurrence of complications was performed. The impacts of different embolisms on the prognosis were compared.The median follow-up time in the neck and aneurysm groups was 17 months (9.62) and 16.5 months (9.54), respectively (P = .799). No differences were found in recurrence, postoperative GOS score, and GOS score at the last follow-up between the 2 groups. The numbers of coils and surgical complications in the neck group were smaller than those in the aneurysm group (P < .001 and P < .030, respectively). After adjusting for age and sex, the embolization method was found to be an independent predictor for surgery-related complications (odds ratio 2.419, 95% confidence interval 1.111-5.269, P = .026).The numbers of coils and surgery-related complications were smaller when embolizing the aneurysmal neck than the entire aneurysm, showing potential advantages of embolization of the aneurysmal neck.
[Mh] Termos MeSH primário: Aneurisma Roto/terapia
Embolização Terapêutica/métodos
Aneurisma Intracraniano/terapia
[Mh] Termos MeSH secundário: Adulto
Vesícula
China
Feminino
Escala de Resultado de Glasgow
Seres Humanos
Aneurisma Intracraniano/complicações
Masculino
Meia-Idade
Prognóstico
Recidiva
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007046


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[PMID]:28758550
[Au] Autor:Yang C; Vadasz A; Szikora I
[Ad] Endereço:Department of Neurointerventions, National Institute of Neurosciences, Budapest, Hungary.
[Ti] Título:Treatment of ruptured blood blister aneurysms using primary flow-diverter stenting with considerations for adjunctive coiling: A single-centre experience and literature review.
[So] Source:Interv Neuroradiol;23(5):465-476, 2017 Oct.
[Is] ISSN:2385-2011
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Objective The objective of this article is to conduct a single-centre evaluation and quick literature review of the effectiveness of primary flow-diverter (FD) treatment of ruptured blood blister aneurysms (BBAs), with additional relevance of adjunctive coiling. Methods Patients presenting with subarachnoid haemorrhage (SAH) due to ruptured BBAs and subsequently treated with FDs were retrospectively selected from June 2010 to January 2017. Treatment techniques, angiographic data on occlusion rates and procedural success as well as clinical outcomes using the modified Rankin Scale (mRS) were collated. Cross-reference of results were made with available literature. Results Thirteen patients harbouring 14 BBAs were recruited. Of the 14 aneurysms, five (35.7%) showed immediate complete occlusion after the procedure (four of these five patients had adjunctive coiling). All of the aneurysms showed complete occlusion by the six- to nine-month control diagnostic angiogram. No rebleed or retreatment was experienced. Twelve of 13 (92%) patients had an mRS score of 0-1 at the last clinical follow-up. From the pooled data of the literature review, eventual aneurysm occlusion was achieved in 48/56 patients, with five patients requiring further endovascular treatment. In the clinical follow-up period, an mRS of 0-2 was recorded for 83.3% (45/54) of patients. Conclusion Endovascular reconstruction of BBAs using FD treatment is an effective method with good final clinical outcomes. Adjunctive use of coiling achieves higher incidence of immediate complete occlusion of BBAs.
[Mh] Termos MeSH primário: Aneurisma Roto/terapia
Vesícula/terapia
Embolização Terapêutica/métodos
Procedimentos Endovasculares
Aneurisma Intracraniano/terapia
Stents
Hemorragia Subaracnóidea/terapia
[Mh] Termos MeSH secundário: Adulto
Idoso
Aneurisma Roto/diagnóstico por imagem
Vesícula/diagnóstico por imagem
Feminino
Seres Humanos
Aneurisma Intracraniano/diagnóstico por imagem
Masculino
Meia-Idade
Estudos Retrospectivos
Hemorragia Subaracnóidea/diagnóstico por imagem
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1177/1591019917720805


  8 / 4021 MEDLINE  
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[PMID]:28736230
[Au] Autor:Alexeev V; Salas-Alanis JC; Palisson F; Mukhtarzada L; Fortuna G; Uitto J; South A; Igoucheva O
[Ad] Endereço:Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
[Ti] Título:Pro-Inflammatory Chemokines and Cytokines Dominate the Blister Fluid Molecular Signature in Patients with Epidermolysis Bullosa and Affect Leukocyte and Stem Cell Migration.
[So] Source:J Invest Dermatol;137(11):2298-2308, 2017 Nov.
[Is] ISSN:1523-1747
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hereditary epidermolysis bullosa (EB) is associated with skin blistering and the development of chronic nonhealing wounds. Although clinical studies have shown that cell-based therapies improve wound healing, the recruitment of therapeutic cells to blistering skin and to more advanced skin lesions remains a challenge. Here, we analyzed cytokines and chemokines in blister fluids of patients affected by dystrophic, junctional, and simplex EB. Our analysis revealed high levels of CXCR1, CXCR2, CCR2, and CCR4 ligands, particularly dominant in dystrophic and junctional EB. In vitro migration assays demonstrated the preferential recruitment of CCR4 lymphocytes and CXCR1 , CXCR2 , and CCR2 myeloid cells toward EB-derived blister fluids. Immunophenotyping of skin-infiltrating leukocytes confirmed substantial infiltration of EB-affected skin with resting (CD45RA ) and activated (CD45RO ) T cells and CXCR2 CD11b cells, many of which were identified as CD16b neutrophils. Our studies also showed that abundance of CXCR2 ligand in blister fluids also creates a favorable milieu for the recruitment of the CXCR2 stem cells, as validated by in vitro and in-matrix migration assays. Collectively, this study identified several chemotactic pathways that control the recruitment of leukocytes to the EB-associated skin lesions. These chemotactic axes could be explored for the refinement of the cutaneous homing of the therapeutic stem cells.
[Mh] Termos MeSH primário: Quimiocinas/genética
Citocinas/genética
Epidermólise Bolhosa/genética
Epidermólise Bolhosa/patologia
Receptores CXCR/genética
[Mh] Termos MeSH secundário: Vesícula/patologia
Movimento Celular/genética
Células Cultivadas
Progressão da Doença
Feminino
Regulação da Expressão Gênica
Seres Humanos
Leucócitos/metabolismo
Leucócitos/patologia
Masculino
Biologia Molecular
Prognóstico
Amostragem
Sensibilidade e Especificidade
Células-Tronco/metabolismo
Células-Tronco/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chemokines); 0 (Cytokines); 0 (Receptors, CXCR)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170725
[St] Status:MEDLINE


  9 / 4021 MEDLINE  
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[PMID]:28542372
[Au] Autor:Laspas P; Culmann PD; Grus FH; Prokosch-Willing V; Poplawksi A; Pfeiffer N; Hoffmann EM
[Ad] Endereço:Department of Ophthalmology, University Medical Center, Johannes Gutenberg- University Mainz, Mainz, Germany.
[Ti] Título:Revision of encapsulated blebs after trabeculectomy: Long-term comparison of standard bleb needling and modified needling procedure combined with transconjunctival scleral flap sutures.
[So] Source:PLoS One;12(5):e0178099, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To compare two surgical approaches for treating encapsulated blebs after trabeculectomy with mitomycin C, in terms of the development of intraocular pressure and progression of glaucoma in a long-term follow up: 1. bleb needling alone vs. 2. a combined approach of needling with additional transconjunctival scleral flap sutures, to prevent early ocular hypotony. METHODS: Forty-six patients with failing blebs after trabeculectomy with mitomycin C were enrolled in this study. Patients received either needling revision alone (group 1; n = 23) or a combined needling with additional transconjuctival flap sutures, if intraoperatively the intraocular pressure was estimated to be low (group 2; n = 23). Intraocular pressure (IOP), visual acuity, visual fields, and optic nerve head configuration by means of Heidelberg Retina Tomograph (HRT®) were analysed over time. Results from both groups were compared using Mann-Whitney U-test for single timepoints. RESULTS: IOP did not differ significantly between the two groups during follow-up at three months (P = 0.13), six months (P = 0.12), one year (P = 0.92) and two years (P = 0.57) after surgery. Furthermore, there was no significant difference in the course of glaucoma concerning the optic nerve anatomy between the two groups (Rim Area Change in the Moorfields Regression Analysis of HRT®) till two years after surgery (P = 0.289). No functional impairment in visual acuity and visual fields was found in the groups of the study. CONCLUSIONS: Single needling procedure is a standard successful method for restoring the function of encapsulated blebs. Postoperative hypotony represents a possible hazard, which can be minimized by additional transconjunctival flap sutures. Long-term results suggest that this modification is equally effective in lowering the IOP and preventing the progression of glaucoma as the standard needling procedure. To our knowledge this is the first study to investigate the long-term effect of tranconjunctival sutures for the prevention of hypotony.
[Mh] Termos MeSH primário: Vesícula/cirurgia
Trabeculectomia/métodos
[Mh] Termos MeSH secundário: Antibióticos Antineoplásicos/farmacologia
Antibióticos Antineoplásicos/uso terapêutico
Vesícula/tratamento farmacológico
Túnica Conjuntiva/cirurgia
Feminino
Seguimentos
Seres Humanos
Pressão Intraocular/efeitos dos fármacos
Pressão Intraocular/fisiologia
Masculino
Meia-Idade
Mitomicina/farmacologia
Mitomicina/uso terapêutico
Disco Óptico/fisiologia
Retalhos Cirúrgicos
Tonometria Ocular
Acuidade Visual/fisiologia
Campos Visuais/fisiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibiotics, Antineoplastic); 50SG953SK6 (Mitomycin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178099


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[PMID]:28403057
[Au] Autor:Paulmann M; Mockenhaupt M
[Ad] Endereço:From the Department of Dermatology, Dokumentationszentrum schwerer Hautreaktionen (dZh), Medical Center-University of Freiburg, Hauptstrasse 7, 79104 Freiburg, Germany.
[Ti] Título:Fever in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Pediatric Cases: Laboratory Work-up and Antibiotic Therapy.
[So] Source:Pediatr Infect Dis J;36(5):513-515, 2017 May.
[Is] ISSN:1532-0987
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fever is a symptom that often accompanies skin eruptions, especially in children. It can be a sign of an infectious condition presenting with exanthems or it may precede an exanthematous eruption. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe reactions affecting skin and mucosa with blisters and erosions. High fever occurs in these conditions, frequently before the skin and/or mucosa is affected.
[Mh] Termos MeSH primário: Vesícula/diagnóstico
Eritema Multiforme/diagnóstico
Febre/diagnóstico
Síndrome de Stevens-Johnson/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Analgésicos/efeitos adversos
Antibacterianos/uso terapêutico
Antipiréticos/efeitos adversos
Infecções Bacterianas/complicações
Infecções Bacterianas/diagnóstico
Infecções Bacterianas/tratamento farmacológico
Infecções Bacterianas/patologia
Vesícula/tratamento farmacológico
Vesícula/etiologia
Vesícula/patologia
Criança
Diagnóstico Diferencial
Eritema Multiforme/tratamento farmacológico
Eritema Multiforme/etiologia
Eritema Multiforme/patologia
Feminino
Febre/tratamento farmacológico
Febre/etiologia
Febre/patologia
Seres Humanos
Masculino
Membrana Mucosa/patologia
Pele/patologia
Síndrome de Stevens-Johnson/tratamento farmacológico
Síndrome de Stevens-Johnson/etiologia
Síndrome de Stevens-Johnson/patologia
Viroses/complicações
Viroses/diagnóstico
Viroses/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Bacterial Agents); 0 (Antipyretics)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.1097/INF.0000000000001571



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