[PMID]: | 27617457 |
[Au] Autor: | Gameiro A; Gouveia M; Tellechea O; Goncalo M |
[Ad] Endereço: | Coimbra University Hospital, Coimbra. |
[Ti] Título: | Vancomycin-induced linear IgA bullous dermatosis: associations. |
[So] Source: | Dermatol Online J;22(4), 2016 Apr 18. |
[Is] ISSN: | 1087-2108 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | UNLABELLED: Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disease. LABD is considered mostly idiopathic, butsome cases have been reported to be drug-induced, mainly associated with vancomycin (VCM).We present two cases of LABD possibly associated with VCM used for cardiac surgery prophylaxis; in the presented cases, the eruptions occurred only after VCM withdrawal, therefore leaving a question about the relationship between VCM and LABD in these cases.We reviewed previous reports of VCM-induced LABD and analyzed the following parameters: gender, age, recent medical history, concurrent medication, latency period, progression after withdrawal, time to resolution, treatment, and rechallenge. RESULTS: The causal relationship between VCM and LABD was often unclear; patients frequently had concurrent medication and symptoms frequently began and/or progressed after VCM withdrawal. Among the 46 reviewed patients in addition to our two cases (n=48), 20 (42%) had recent history of cardiac procedure, cardiac infection, congestive heart failure, or aortic aneurism. CONCLUSION: Further investigation is needed to ascertain the association between LABD, VCM, and heart disease. |
[Mh] Termos MeSH primário: |
Antibacterianos/efeitos adversos Dermatoses Faciais/induzido quimicamente Dermatoses da Perna/induzido quimicamente Dermatose Linear Bolhosa por IgA/induzido quimicamente Vancomicina/efeitos adversos
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[Mh] Termos MeSH secundário: |
Idoso Dermatoses Faciais/patologia Seres Humanos Dermatoses da Perna/patologia Dermatose Linear Bolhosa por IgA/patologia Masculino Meia-Idade
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[Pt] Tipo de publicação: | CASE REPORTS; JOURNAL ARTICLE; REVIEW |
[Nm] Nome de substância:
| 0 (Anti-Bacterial Agents); 6Q205EH1VU (Vancomycin) |
[Em] Mês de entrada: | 1704 |
[Cu] Atualização por classe: | 170425 |
[Lr] Data última revisão:
| 170425 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 160913 |
[St] Status: | MEDLINE |
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