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[PMID]:28212277
[Au] Autor:Toyoda Y; Takada T; Gomi T; Nakagawa H; Ishikawa T; Suzuki H
[Ad] Endereço:Department of Pharmacy, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. ytoyoda-tky@umin.ac.jp.
[Ti] Título:Clinical and Molecular Evidence of ABCC11 Protein Expression in Axillary Apocrine Glands of Patients with Axillary Osmidrosis.
[So] Source:Int J Mol Sci;18(2), 2017 Feb 15.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Accumulating evidence suggests that the risk of axillary osmidrosis is governed by a non-synonymous single nucleotide polymorphism (SNP) 538G>A in human ( ) gene. However, little data are available for the expression of ABCC11 protein in human axillary apocrine glands that produce apocrine sweat-a source of odor from the armpits. To determine the effect of the non-synonymous SNP 538G>A (G180R) on the ABCC11 in vivo, we generated transiently ABCC11-expressing transgenic mice with adenovirus vector, and examined the protein levels of each ABCC11 in the mice with immunoblotting using an anti-ABCC11 antibody we have generated in the present study. Furthermore, we examined the expression of ABCC11 protein in human axillary apocrine glands extracted from axillary osmidrosis patients carrying each genotype: 538GG, GA, and AA. Analyses of transiently ABCC11-expressing transgenic mice showed that 538G>A diminishes the ABCC11 protein levels in vivo. Consistently, ABCC11 protein was detected in the human axillary apocrine glands of the 538GG homozygote or 538GA heterozygote, not in the 538AA homozygote. These findings would contribute to a better understanding of the molecular basis of axillary osmidrosis.
[Mh] Termos MeSH primário: Transportadores de Cassetes de Ligação de ATP/metabolismo
Glândulas Apócrinas/metabolismo
Axila
Doenças das Glândulas Sudoríparas/metabolismo
[Mh] Termos MeSH secundário: Transportadores de Cassetes de Ligação de ATP/genética
Animais
Modelos Animais de Doenças
Expressão Gênica
Genótipo
Seres Humanos
Masculino
Camundongos
Camundongos Transgênicos
Polimorfismo de Nucleotídeo Único
Doenças das Glândulas Sudoríparas/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ABCC11 protein, human)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE


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[PMID]:27748694
[Au] Autor:Ho WT; Lee LJ; Pan JY
[Ad] Endereço:Department of Dermatology, Ho Wen Tsao Skin Clinic, New Taipei City, Taiwan National Institute of Environmental Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan Department of Dermatology, National Skin Centre, Singapore.
[Ti] Título:Following Changes in the Axillary Secretions of Two Patients Before and After Bromhidrosis Surgery Using Liquid Chromatography-Mass Spectrometry.
[So] Source:Dermatol Surg;43(3):459-462, 2017 Mar.
[Is] ISSN:1524-4725
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças das Glândulas Sudoríparas/cirurgia
Suor/química
[Mh] Termos MeSH secundário: Axila
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Odorantes
Cuidados Pós-Operatórios
Cuidados Pré-Operatórios
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161018
[St] Status:MEDLINE
[do] DOI:10.1097/DSS.0000000000000934


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[PMID]:27740956
[Au] Autor:Shin JY; Roh SG; Lee NH; Yang KM
[Ad] Endereço:From the *Department of Plastic and Reconstructive Surgery, Medical School of Chonbuk National University; and †Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeounju, Republic of Korea.
[Ti] Título:Osmidrosis Treatment Approaches: A Systematic Review and Meta-Analysis.
[So] Source:Ann Plast Surg;78(3):354-359, 2017 Mar.
[Is] ISSN:1536-3708
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There are many treatment modalities associated with osmidrosis. The purpose of this study was to identify and compare effective osmidrosis treatments. METHODS: A systematic literature review and meta-analysis were performed using MEDLINE, EMBASE, and Cochrane databases. The osmidrosis treatment modalities were extracted as predictor variables, and recurrence and complications were extracted as outcome variables. Subgroup analysis was performed with regard to combined curettage, and fixed and random effect models were applied. RESULTS: Forty studies published prior to February 2016 were identified. The group that received surgery had the lowest incidence of recurrence as 3.0%, followed by the liposuction and laser groups (5.5%, 8.2%, respectively). The liposuction group had the lowest incidence of complications (hematoma, 1.6%; necrosis, 1.5%), followed by the surgery (hematoma, 1.9%; necrosis, 2.1%) and laser groups (hematoma, 3.1%; necrosis, 4.5%). When combining curettage, the recurrence rate was lower in the surgery (P = 0.06) and liposuction groups (P < 0.01). CONCLUSIONS: Surgery treatment has been demonstrated as the most effective result for treating osmidrosis. Liposuction has been identified as the most effective treatment, with the lowest number of associated complications. Combining the curettage method was an effective option for lowering recurrence rate in surgery and liposuction treatments. Finally, laser treatment was not significantly associated with benefits.
[Mh] Termos MeSH primário: Doenças das Glândulas Sudoríparas/terapia
[Mh] Termos MeSH secundário: Axila
Terapia Combinada
Curetagem
Seres Humanos
Terapia a Laser
Lipectomia
Modelos Estatísticos
Odorantes
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161015
[St] Status:MEDLINE
[do] DOI:10.1097/SAP.0000000000000911


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[PMID]:27617526
[Au] Autor:Vajdi T; Lee WW; Paravar T
[Ad] Endereço:University of California, San Diego School of Medicine.
[Ti] Título:Penicillamine-associated cutis laxa and milia en plaque - case report and review of cutaneous changes associated with penicillamine.
[So] Source:Dermatol Online J;22(5), 2016 May 15.
[Is] ISSN:1087-2108
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Penicillamine-induced skin changes are rare and include: hypersensitivity reactions, autoimmune reactions, and cutaneous elastoses. We report a case of a 73-year-old man with cystinuria taking penicillamine for over 50 years who presented with penicillamine-induced cutis laxa and milia en plaque. A brief review of penicillamine induced skin changes, specifically cutis laxa and milia en plaque, is presented.
[Mh] Termos MeSH primário: Quelantes/efeitos adversos
Cútis Laxa/induzido quimicamente
Cistinúria/tratamento farmacológico
Penicilamina/efeitos adversos
Doenças das Glândulas Sudoríparas/induzido quimicamente
[Mh] Termos MeSH secundário: Idoso
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Chelating Agents); GNN1DV99GX (Penicillamine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160913
[St] Status:MEDLINE


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[PMID]:27584963
[Au] Autor:Murota H
[Ad] Endereço:Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
[Ti] Título:Sweating in Systemic Abnormalities: Uremia and Diabetes Mellitus.
[So] Source:Curr Probl Dermatol;51:57-61, 2016.
[Is] ISSN:1662-2944
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Sweating disorders are sometimes observed in various systemic diseases that include genetic disorders, organ damage, metabolic impairment, autoimmune diseases, and neuropathic disorders. In these diseases, various symptoms such as autonomic failures, psychopathic disorders, abnormal skin innervation, and sweat gland dysfunction can interact with one another in diverse ways, resulting in impaired sweating. This review focuses on the influence of uremia (with or without hemodialysis) and diabetes mellitus on impaired sweating. Dialysis patients perspire less, but their sweat contains higher levels of uremic toxins than do healthy subjects. Neuropathic disorders in diabetes patients develop in relation to disease severity and can impair sweating. Physicians should consider the development of various problems, such as increased body temperature, dry skin, and increased susceptibility to infection, due to decreased sweating, as they are often found in these systemic abnormalities.
[Mh] Termos MeSH primário: Diabetes Mellitus
Neuropatias Diabéticas/complicações
Hipo-Hidrose/etiologia
Falência Renal Crônica/complicações
Uremia/complicações
[Mh] Termos MeSH secundário: Neuropatias Diabéticas/fisiopatologia
Seres Humanos
Hipo-Hidrose/fisiopatologia
Falência Renal Crônica/terapia
Diálise Renal/efeitos adversos
Suor/química
Doenças das Glândulas Sudoríparas/etiologia
Doenças das Glândulas Sudoríparas/fisiopatologia
Glândulas Sudoríparas/inervação
Glândulas Sudoríparas/fisiopatologia
Sudorese
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160902
[St] Status:MEDLINE
[do] DOI:10.1159/000446760


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[PMID]:27584961
[Au] Autor:Wataya-Kaneda M
[Ad] Endereço:Department of Dermatology, Graduate School of Medicine, Osaka University, Osaka, Japan.
[Ti] Título:Genetic Disorders with Dyshidrosis: Ectodermal Dysplasia, Incontinentia Pigmenti, Fabry Disease, and Congenital Insensitivity to Pain with Anhidrosis.
[So] Source:Curr Probl Dermatol;51:42-9, 2016.
[Is] ISSN:1662-2944
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Sweating is regulated by various neurohormonal mechanisms. A disorder in any part of the sweating regulatory pathways, such as the thermal center, neurotransmitters in the central to peripheral nerve, innervation of periglandular neurotransmission, and sweat secretion in the sweat gland itself, induces dyshidrosis. Therefore, hereditary disorders with dyshidrosis result from a variety of causes. These diseases have characteristic symptoms derived from each pathogenesis besides dyshidrosis. The information in this chapter is useful for the differential diagnosis of representative genetic disorders with dyshidrosis.
[Mh] Termos MeSH primário: Displasia Ectodérmica/fisiopatologia
Doença de Fabry/fisiopatologia
Neuropatias Hereditárias Sensoriais e Autônomas/fisiopatologia
Incontinência Pigmentar/fisiopatologia
[Mh] Termos MeSH secundário: Displasia Ectodérmica/genética
Doença de Fabry/genética
Neuropatias Hereditárias Sensoriais e Autônomas/genética
Seres Humanos
Incontinência Pigmentar/genética
Doenças das Glândulas Sudoríparas/genética
Doenças das Glândulas Sudoríparas/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160902
[St] Status:MEDLINE
[do] DOI:10.1159/000446757


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[PMID]:27584959
[Au] Autor:Murota H
[Ad] Endereço:Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
[Ti] Título:Old and New Approaches for Assessing Sweating.
[So] Source:Curr Probl Dermatol;51:22-9, 2016.
[Is] ISSN:1662-2944
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The evaluation of sweating activities contributes to both medical services and social living. There are several old and new approaches for assessing sweating. These methods are mainly composed of adopted techniques that focus on detecting small amounts of water on the skin surface. For many years, the iodine-starch reaction has been applied in various settings to evaluate sweat on the skin surface. However, methodology based on the coloration of sweat is in a constant state of evolution, and multiple advancements have been made. Furthermore, common fingerprinting is not just used for obtaining personal-identifying information anymore as it can also provide scientifically important information for sweat-pore mapping and sweat-component analysis. Additionally, there are multiple techniques for the quantitative measurement of sweat volume and dynamic intravital imaging of sweat, and these are also continually evolving. This chapter provides an overview of the old and new approaches for assessing sweating.
[Mh] Termos MeSH primário: Doenças das Glândulas Sudoríparas/diagnóstico
Glândulas Sudoríparas/diagnóstico por imagem
Sudorese/fisiologia
[Mh] Termos MeSH secundário: Resposta Galvânica da Pele
Seres Humanos
Microscopia de Fluorescência
Manejo de Espécimes
Suor/química
Doenças das Glândulas Sudoríparas/fisiopatologia
Glândulas Sudoríparas/fisiopatologia
Tomografia de Coerência Óptica
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160902
[St] Status:MEDLINE
[do] DOI:10.1159/000446755


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[PMID]:27430692
[Au] Autor:Guo XH; Yang GY; Li CB; Wang LJ; Zhang J; Yuan XJ
[Ad] Endereço:Department of Pathology, Zhuhai People's Hospital, Zhuhai 519000, China.
[Ti] Título:[Eccrine angiomatous hamartoma: a clinicalopathologic analysis of 4 cases].
[So] Source:Zhonghua Bing Li Xue Za Zhi;45(7):467-71, 2016 Jul 08.
[Is] ISSN:0529-5807
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To investigate the clinical and histopathologic features, diagnosis and differential diagnosis of eccrine angiomatous hamartoma(EAH). METHODS: Four cases of eccrine angiomatous hamartoma were studied by light microscopy and immunohistochemical staining along with review of the literature. RESULTS: There were 3 male and 1 female patients at diagnosis in age of 4 months, 3.5 years, 5.5 years and 14.0 years, respectively. Tumor sites included the left little finger (1 case), right index finger (1 case), lower back (1 case) and knee (1 case). Clinically, most cases presented as a solitary, flesh or reddish papule, plaque or nodule with size of 0.4-6.0 cm in diameter. The skin lesions in 3 cases enlarged commensurate with the growth of the patients, and local hyperhidrosis in one case. Histologically, EAH was characterized by proliferation of well-differentiated eccrine secretory and ductal elements closely associated with thin-walled angiomatous channels in the middle or deep dermis and subcutaneous tissue. By immunohistochemistry, the vascular components were positive for CD31, CD34 and factor â…§ related antigen while the eccrine glands were positive for S-100 protein, CEA, EMA, CAM5.2 and GCDFP15. Local surgical resection was performed in 4 cases and follow-up data (0.5 to 4.5 years) showed no recurrence. CONCLUSION: EAH is a rare, benign cutaneous hamartoma. Combination of clinical manifestations, histological changes and immunohistochemical findings is useful for the diagnosis and differential diagnosis.
[Mh] Termos MeSH primário: Glândulas Écrinas/patologia
Hamartoma/patologia
Doenças das Glândulas Sudoríparas/patologia
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Glândulas Écrinas/química
Feminino
Seres Humanos
Imuno-Histoquímica
Masculino
Dermatopatias/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170117
[Lr] Data última revisão:
170117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160720
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-5807.2016.07.008


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[PMID]:27207185
[Au] Autor:Zhao H; Li S; Nabi O; Hu L; Gao X; Luo F
[Ad] Endereço:Department of Dermatology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
[Ti] Título:Treatment of axillary bromhidrosis through a mini-incision with subdermal vascular preservation: a retrospective study in 396 patients.
[So] Source:Int J Dermatol;55(8):919-25, 2016 Aug.
[Is] ISSN:1365-4632
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Axillary bromhidrosis is a condition presenting as malodor caused by an interaction between the discharge of apocrine glands and bacteria. Topical agents, liposuction, and elective surgery are currently the main therapeutic modalities. However, the efficiency of these treatments and incidences of side effects are various and frequent, and depend on patient characteristics, surgical technique, and other unknown factors. METHODS: We report a retrospective study of outcomes in 396 patients treated by mini-incision with subdermal vascular preservation. RESULTS: At 2 years postoperatively, 87.1% of patients had achieved very satisfactory results. Short-term side effects included hematomas, epidermal erosions, infections, necrosis, incision dehiscence, and skin ripples. Long-term side effects comprised comedones, epidermoid cysts, relapsing cyst infections, skin gauffers, scars, keloids, and persistent malodor. Some patients reported unsatisfactory cosmetic results, including skin gauffers, scars, or epidermoid cyst formations. CONCLUSIONS: Two discrete aspects of the procedure that must be considered are the extent of apocrine gland clearance, which must be thorough in order to achieve the resolution of malodor, and the maintenance of an intact subdermal vascular plexus to support the regrowth of skin flaps after surgery and to avoid the occurrence of severe side effects.
[Mh] Termos MeSH primário: Glândulas Apócrinas/secreção
Glândulas Apócrinas/cirurgia
Axila/cirurgia
Hiperidrose/cirurgia
Doenças das Glândulas Sudoríparas/diagnóstico
Doenças das Glândulas Sudoríparas/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Glândulas Apócrinas/fisiopatologia
Cicatriz/etiologia
Cicatriz/cirurgia
Estudos de Coortes
Procedimentos Cirúrgicos Dermatológicos/efeitos adversos
Procedimentos Cirúrgicos Dermatológicos/métodos
Feminino
Seguimentos
Seres Humanos
Hiperidrose/fisiopatologia
Masculino
Meia-Idade
Procedimentos Cirúrgicos Minimamente Invasivos/métodos
Odorantes
Complicações Pós-Operatórias/fisiopatologia
Complicações Pós-Operatórias/terapia
Estudos Retrospectivos
Índice de Gravidade de Doença
Pele/irrigação sanguínea
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160522
[St] Status:MEDLINE
[do] DOI:10.1111/ijd.13313


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[PMID]:27098803
[Au] Autor:Wang T; Liang S; Liu YH; Lian CG
[Ti] Título:Unilateral Axillary Pseudochromhidrosis-like Lesion Caused by Pediculosis Pubis.
[So] Source:Chin Med J (Engl);129(9):1133-4, 2016 May 05.
[Is] ISSN:0366-6999
[Cp] País de publicação:China
[La] Idioma:eng
[Mh] Termos MeSH primário: Infestações por Piolhos/complicações
Phthirus
Doenças das Glândulas Sudoríparas/etiologia
[Mh] Termos MeSH secundário: Animais
Axila
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170307
[Lr] Data última revisão:
170307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160422
[St] Status:MEDLINE
[do] DOI:10.4103/0366-6999.180525



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