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[PMID]:28976856
[Au] Autor:Palmer BF; Clegg DJ
[Ad] Endereço:From the Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas (B.F.P.); and the Department of Biomedical Sciences, Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles (D.J.C.).
[Ti] Título:Electrolyte Disturbances in Patients with Chronic Alcohol-Use Disorder.
[So] Source:N Engl J Med;377(14):1368-1377, 2017 Oct 05.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Desequilíbrio Ácido-Base/etiologia
Alcoolismo/complicações
Desequilíbrio Hidroeletrolítico/etiologia
[Mh] Termos MeSH secundário: Desequilíbrio Ácido-Base/tratamento farmacológico
Alcoolismo/fisiopatologia
Seres Humanos
Hiponatremia/etiologia
Cetose/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMra1704724


  2 / 1578 MEDLINE  
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[PMID]:28934742
[Au] Autor:Du X; Chen L; Huang D; Peng Z; Zhao C; Zhang Y; Zhu Y; Wang Z; Li X; Liu G
[Ad] Endereço:Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.
[Ti] Título:Elevated Apoptosis in the Liver of Dairy Cows with Ketosis.
[So] Source:Cell Physiol Biochem;43(2):568-578, 2017.
[Is] ISSN:1421-9778
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIMS: Dairy cows with ketosis are characterized by oxidative stress and hepatic damage. The aim of this study was to investigate hepatic oxidative stress and the apoptotic status of ketotic cows, as well as the underlying apoptosis pathway. METHODS: The blood aspartate aminotransferase (AST), alanine aminotransferase (ALT), glutamate dehydrogenase (GLDH) and gamma-glutamyl transferase (GGT) activities and the haptoglobin (HP), serum amyloid A (SAA) and serum apoptotic cytokeratin 18 neo-epitope M30 (CK18 M30) concentrations were determined by commercially available kits and ELISA kits, respectively. Liver histology, TUNEL and Oil red O staining were performed in liver tissue samples. TG contents were measured using an enzymatic kit; Caspase 3 assays were carried out using the Caspase 3 activity assay kit; oxidation and antioxidant markers were measured using biochemical kits; apoptosis pathway were determined by qRT-PCR and western blot. RESULTS: Ketotic cows displayed hepatic fat accumulation. The hepatic malondialdehyde (MDA) content was significantly increased, but the activities of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were markedly decreased in ketotic cows compared with control cows, indicating that ketotic cows displayed severe oxidative stress. Significantly higher serum levels of the hepatic damage markers AST, ALT, GGT and GLDH were observed in ketotic cows than in control cows. The blood concentration of the apoptotic marker CK18 M30 and the number of TUNEL-positive cells in the liver of ketotic cows were 1.19- and 2.61-fold, respectively, higher than the values observed in control cows. Besides, Caspase 3 activity was significantly increased in the liver of ketosis cows. Importantly, the levels of phosphorylated c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38MAPK) were significantly increased but the level of phosphorylated extracellular signal-regulated kinase1/2 (ERK1/2) was markedly decreased, which further promoted tumor protein 53 (p53) expression and inhibited nuclear factor E2-related factor 2 (Nrf2) expression. The apoptosis-related molecules p21, MDM2, Caspase 3, Caspase 9 and Bax were expressed at significantly higher levels in ketotic cows than in healthy cows, whereas the anti-apoptosis molecule Bcl-2 was expressed at significantly lower levels. CONCLUSIONS: Based on these results, ketotic cows display severe hepatic oxidative stress. The hepatic MAPK-p53-Nrf2 apoptotic pathway is over induced and partially mediated apoptotic damage in the liver.
[Mh] Termos MeSH primário: Apoptose
Doenças dos Bovinos/patologia
Cetose/veterinária
Fígado/patologia
Estresse Oxidativo
[Mh] Termos MeSH secundário: Alanina Transaminase/sangue
Animais
Aspartato Aminotransferases/sangue
Bovinos
Doenças dos Bovinos/sangue
Doenças dos Bovinos/metabolismo
Feminino
Glutamato Desidrogenase/sangue
Cetose/sangue
Cetose/metabolismo
Cetose/patologia
Fígado/metabolismo
gama-Glutamiltransferase/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 1.4.1.2 (Glutamate Dehydrogenase); EC 2.3.2.2 (gamma-Glutamyltransferase); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1159/000480529


  3 / 1578 MEDLINE  
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[PMID]:28524016
[Au] Autor:Steensels M; Maltz E; Bahr C; Berckmans D; Antler A; Halachmi I
[Ad] Endereço:Institute of Agricultural Engineering,Agricultural Research Organization (ARO) - the Volcani Center,PO Box 6,Bet-Dagan 50250,Israel.
[Ti] Título:Towards practical application of sensors for monitoring animal health: the effect of post-calving health problems on rumination duration, activity and milk yield.
[So] Source:J Dairy Res;84(2):132-138, 2017 May.
[Is] ISSN:1469-7629
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Three sources of sensory data: cow's individual rumination duration, activity and milk yield were evaluated as possible indicators for clinical diagnosis, focusing on post-calving health problems such as ketosis and metritis. Data were collected from a computerised dairy-management system on a commercial dairy farm with Israeli Holstein cows. In the analysis, 300 healthy and 403 sick multiparous cows were studied during the first 3 weeks after calving. A mixed model with repeated measurements was used to compare healthy cows with sick cows. In the period from 5 d before diagnosis and treatment to 2 d after it, rumination duration and activity were lower in the sick cows compared to healthy cows. The milk yield of sick cows was lower than that of the healthy cows during a period lasting from 5 d before until 5 d after the day of diagnosis and treatment. Differences in the milk yield of sick cows compared with healthy cows became greater from 5 to 1 d before diagnosis and treatment. The greatest significant differences occurred 3 d before diagnosis for rumination duration and 1 d before diagnosis for activity and milk yield. These results indicate that a model can be developed to automatically detect post-calving health problems including ketosis and metritis, based on rumination duration, activity and milk yield.
[Mh] Termos MeSH primário: Doenças dos Bovinos/diagnóstico
Lactação/fisiologia
Monitorização Fisiológica/veterinária
Transtornos Puerperais/veterinária
Rúmen/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Bovinos
Doenças dos Bovinos/fisiopatologia
Endometrite/diagnóstico
Endometrite/veterinária
Feminino
Cetose/diagnóstico
Cetose/veterinária
Monitorização Fisiológica/instrumentação
Gravidez
Transtornos Puerperais/diagnóstico
Transtornos Puerperais/fisiopatologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE
[do] DOI:10.1017/S0022029917000176


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[PMID]:28524012
[Au] Autor:Steensels M; Maltz E; Bahr C; Berckmans D; Antler A; Halachmi I
[Ad] Endereço:Institute of Agricultural Engineering - Agricultural Research Organization (ARO) - The Volcani Center,PO Box 6,Bet-Dagan 50250,Israel.
[Ti] Título:Towards practical application of sensors for monitoring animal health; design and validation of a model to detect ketosis.
[So] Source:J Dairy Res;84(2):139-145, 2017 May.
[Is] ISSN:1469-7629
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to design and validate a mathematical model to detect post-calving ketosis. The validation was conducted in four commercial dairy farms in Israel, on a total of 706 multiparous Holstein dairy cows: 203 cows clinically diagnosed with ketosis and 503 healthy cows. A logistic binary regression model was developed, where the dependent variable is categorical (healthy/diseased) and a set of explanatory variables were measured with existing commercial sensors: rumination duration, activity and milk yield of each individual cow. In a first validation step (within-farm), the model was calibrated on the database of each farm separately. Two thirds of the sick cows and an equal number of healthy cows were randomly selected for model validation. The remaining one third of the cows, which did not participate in the model validation, were used for model calibration. In order to overcome the random selection effect, this procedure was repeated 100 times. In a second (between-farms) validation step, the model was calibrated on one farm and validated on another farm. Within-farm accuracy, ranging from 74 to 79%, was higher than between-farm accuracy, ranging from 49 to 72%, in all farms. The within-farm sensitivities ranged from 78 to 90%, and specificities ranged from 71 to 74%. The between-farms sensitivities ranged from 65 to 95%. The developed model can be improved in future research, by employing other variables that can be added; or by exploring other models to achieve greater sensitivity and specificity.
[Mh] Termos MeSH primário: Doenças dos Bovinos/diagnóstico
Cetose/veterinária
Monitorização Fisiológica/veterinária
Transtornos Puerperais/veterinária
[Mh] Termos MeSH secundário: Animais
Comportamento Animal
Bovinos
Indústria de Laticínios/métodos
Feminino
Israel
Cetose/diagnóstico
Modelos Teóricos
Monitorização Fisiológica/instrumentação
Monitorização Fisiológica/métodos
Paridade
Gravidez
Transtornos Puerperais/diagnóstico
Transtornos Puerperais/fisiopatologia
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE
[do] DOI:10.1017/S0022029917000188


  5 / 1578 MEDLINE  
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[PMID]:28508677
[Au] Autor:Nakajima K; Oda E
[Ad] Endereço:a School of Nutrition and Dietetics, Faculty of Health and Social Services , Kanagawa University of Human Services , Yokosuka , Kanagawa , Japan.
[Ti] Título:Ketonuria may be associated with low serum amylase independent of body weight and glucose metabolism.
[So] Source:Arch Physiol Biochem;123(5):293-296, 2017 Dec.
[Is] ISSN:1744-4160
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Ketonuria, which reflects a preferential combustion of lipids relative to carbohydrates, is often observed in lean rather than obese people. Clinical studies have shown that individuals with diabetes and/or obesity predispose to have low serum amylase (LSA). OBJECTIVE: To investigate the association between ketonuria and LSA. METHODS: We examined ketonuria assessed by dipstick urinalysis and clinical parameters including serum amylase in 3638 Japanese people aged 25-79 years who underwent a health-screening checkup. RESULTS: There was an inverse relationship between body mass index (BMI) and serum amylase. The lowest serum amylase was observed in obese subjects (BMI ≥ 25.0 kg/m ) with positive ketonuria. Logistic regression analysis showed that ketonuria was significantly associated with LSA (<50 IU/L), which was not altered by the adjustments for relevant confounders including age, sex, BMI, and HbA1c. CONCLUSIONS: Current results suggest a relative unavailability of carbohydrates for energy production in individuals with LSA.
[Mh] Termos MeSH primário: Amilases/sangue
Cetose/sangue
Cetose/enzimologia
[Mh] Termos MeSH secundário: Peso Corporal
Feminino
Glucose/metabolismo
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.2.1.- (Amylases); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE
[do] DOI:10.1080/13813455.2017.1326941


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[PMID]:28482939
[Au] Autor:Rivera-Zavala JB; Molina-Aguilar C; Pérez-Mendoza M; Olguín-Martínez M; Hernández-Muñoz R; Báez-Ruiz GA; Díaz-Muñoz M
[Ad] Endereço:1Departamento de Neurobiología Celular y Molecular,Instituto de Neurobiología,Universidad Nacional Autónoma de México,Campus UNAM-Juriquilla,Querétaro,Mexico76230.
[Ti] Título:Daytime restricted feeding modifies the daily regulation of fatty acid ß-oxidation and the lipoprotein profile in rats.
[So] Source:Br J Nutr;117(7):930-941, 2017 Apr.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Daytime restricted feeding (2 h of food access from 12.00 to 14.00 hours for 3 weeks) is an experimental protocol that modifies the relationship between metabolic networks and the circadian molecular clock. The precise anatomical locus that controls the biochemical and physiological adaptations to optimise nutrient use is unknown. We explored the changes in liver oxidative lipid handling, such as ß-oxidation and its regulation, as well as adaptations in the lipoprotein profile. It was found that daytime restricted feeding promoted an elevation of circulating ketone bodies before mealtime, an altered hepatic daily rhythmicity of 14CO2 production from radioactive palmitic acid, and an up-regulation of the fatty acid oxidation activators, the α-subunit of AMP-activated protein kinase (AMPK), the deacetylase silent mating type information regulation homolog 1, and the transcriptional factor PPARγ-1α coactivator. An increased localisation of phosphorylated α-subunit of AMPK in the periportal hepatocytes was also observed. Liver hepatic lipase C, important for lipoprotein transformation, showed a change of daily phase with a peak at the time of food access. In serum, there was an increase of LDL, which was responsible for a net elevation of circulating cholesterol. We conclude that our results indicate an enhanced fasting response in the liver during daily synchronisation to food access, which involves altered metabolic and cellular control of fatty acid oxidation as well a significant elevation of serum LDL. These adaptations could be part of the metabolic input that underlies the expression of the food-entrained oscillator.
[Mh] Termos MeSH primário: Proteínas Quinases Ativadas por AMP/metabolismo
Relógios Circadianos
Comportamento Alimentar
Hipercolesterolemia/etiologia
Fígado/metabolismo
Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/metabolismo
Sirtuína 1/metabolismo
[Mh] Termos MeSH secundário: Transporte Ativo do Núcleo Celular
Animais
Ácidos Graxos/metabolismo
Hipercolesterolemia/sangue
Hipercolesterolemia/metabolismo
Hipercolesterolemia/patologia
Corpos Cetônicos/sangue
Cetose/sangue
Cetose/etiologia
Cetose/metabolismo
Cetose/patologia
Lipase/metabolismo
Lipoproteínas LDL/sangue
Fígado/enzimologia
Fígado/patologia
Masculino
Oxirredução
Fosforilação
Processamento de Proteína Pós-Traducional
Distribuição Aleatória
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Ketone Bodies); 0 (Lipoproteins, LDL); 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha); 0 (Ppargc1a protein, rat); EC 2.7.11.1 (AMP-activated protein kinase alpha1 protein, rat); EC 2.7.11.31 (AMP-Activated Protein Kinases); EC 3.1.1.3 (Lipase); EC 3.1.1.3 (hepatic lipase, rat); EC 3.5.1.- (Sirt1 protein, rat); EC 3.5.1.- (Sirtuin 1)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517000800


  7 / 1578 MEDLINE  
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[PMID]:28346669
[Au] Autor:Zakian A; Tehrani-Sharif M; Mokhber-Dezfouli MR; Nouri M; Constable PD
[Ad] Endereço:Department of Clinical Science, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran.
[Ti] Título:Evaluation of a point-of-care electrochemical meter to detect subclinical ketosis and hypoglycaemia in lactating dairy cows.
[So] Source:Aust Vet J;95(4):123-128, 2017 Apr.
[Is] ISSN:1751-0813
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To evaluate and validate a hand-held electrochemical meter (Precision Xtra®) as a screening test for subclinical ketosis and hypoglycaemia in lactating dairy cattle. DESIGN: Method comparison study using a convenience sample. PROCEDURE: Blood samples were collected into plain tubes from the coccygeal vessels of 181 Holstein cows at 2-4 weeks of lactation during summer in Iran. Blood ß-hydroxybutyrate concentration (BHB) and glucose concentration were immediately measured by the electrochemical meter after applying 20 µL of blood to the reagent strip. Passing-Bablok regression and Bland-Altman plots were used to determine the accuracy of the meter against laboratory reference methods (BHB dehydrogenase and glucose oxidase). RESULTS: Serum BHB ranged from 0.1 to 7.3 mmol/L and serum glucose ranged from 0.9 to 5.1 mmol/L. Passing-Bablok regression analysis indicated that the electrochemical meter and reference methods were linearly related for BHB and glucose, with a slope estimate that was not significantly different from 1.00. Clinically minor, but statistically significant, differences were present for the intercept value for Passing-Bablok regression analysis for BHB and glucose, and bias estimates in the Bland-Altman plots for BHB and glucose. CONCLUSION: The electrochemical meter provided a clinically useful method to detect subclinical ketosis and hypoglycaemia in lactating dairy cows. Compared with other method validation studies using the meter, we attributed the improved performance of the electrochemical meter to application of a fixed volume of blood (20 µL) to the reagent strip, use of the meter in hot ambient conditions and use of glucose oxidase as the reference method for glucose analysis.
[Mh] Termos MeSH primário: Ácido 3-Hidroxibutírico/sangue
Análise Química do Sangue/veterinária
Doenças dos Bovinos/diagnóstico
Hipoglicemia/veterinária
Cetose/veterinária
Sistemas Automatizados de Assistência Junto ao Leito
[Mh] Termos MeSH secundário: Animais
Análise Química do Sangue/instrumentação
Glicemia/análise
Bovinos
Indústria de Laticínios/instrumentação
Indústria de Laticínios/métodos
Feminino
Hipoglicemia/diagnóstico
Irã (Geográfico)
Cetose/diagnóstico
Lactação
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); TZP1275679 (3-Hydroxybutyric Acid)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170612
[Lr] Data última revisão:
170612
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE
[do] DOI:10.1111/avj.12568


  8 / 1578 MEDLINE  
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[PMID]:28262846
[Au] Autor:Sanya EO; Soladoye AO; Desalu OO; Kolo PM; Olatunji LA; Olarinoye JK
[Ad] Endereço:Department of Medicine, University of Ilorin, Ilorin. emanuelosanya@yahoo.com.
[Ti] Título:Antiseizure Effects of Ketogenic Diet on Seizures Induced with Pentylenetetrazole, 4-Aminopyridine and Strychnine in Wistar Rats.
[So] Source:Niger J Physiol Sci;31(2):115-119, 2017 Mar 06.
[Is] ISSN:0794-859X
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:The ketogenic diet (KD) is a cheap and effective alternative therapy for most epilepsy. There are paucity of experimental data in Nigeria on the usefulness of KD in epilepsy models. This is likely to be responsible for the poor clinical acceptability of the diet in the country. This study therefore aimed at providing experimental data on usefulness of KD on seizure models.  The study used 64 Wistar rats that were divided into two dietary groups [normal diet (ND) and ketogenic diet (KD)]. Animal in each group were fed for 35days. Medium chain triglyceride ketogenic diet (MCT-KD) was used and it consisted of 15% carbohydrate in normal rat chow long with 5ml sunflower oil (25% (v/w). The normal diet was the usual rat chow. Seizures were induced with one of Pentelyntetrazole (PTZ), 4-Aminopyridine (AP) and Strychnine (STR). Fasting glucose, ketosis level and serum chemistry were determined and seizure parameters recorded. Serum ketosis was significantly higher in MCT-KD-fed rats (12.7 ±2.6) than ND-fed (5.17±0.86) rats. Fasting blood glucose was higher in ND-fed rats (5.3±0.9mMol/l) than in MCT-KD fed rats (5.1±0.5mMol/l) with p=0.9. Seizure latency was significantly prolonged in ND-fed compared with MCT-KD fed rats after PTZ-induced seizures (61±9sec vs 570±34sec) and AP-induced seizures (49±11sec vs 483±41sec). The difference after Str-induced seizure (51±7 vs 62±8 sec) was not significan. The differences in seizure duration between ND-fed and MCT-KD fed rats with PTZ (4296±77sec vs 366±46sec) and with AP (5238±102sec vs 480±67sec) were significant (p<0.05), but not with STR (3841±94sec vs 3510±89sec) respectively. The mean serum Na+ was significantly higher in MCT-KD fed (141.7±2.1mMol/l) than ND-fed rats (137±2.3mMol/l). There was no significant difference in mean values of other serum electrolytes between the MCT-KD fed and ND-fed animals. MCT-KD caused increase resistance to PTZ-and AP-induced seizures, but has no effect on STR-induced seizures. This antiseizure property is probably mediated through GABAergic receptors (PTZ effect) and blockade of membrane bound KATP channels (AP effect) with some enhancement by serum ketosis.
[Mh] Termos MeSH primário: 4-Aminopiridina
Fenômenos Fisiológicos da Nutrição Animal
Dieta com Restrição de Carboidratos
Dieta Cetogênica
Pentilenotetrazol
Óleos Vegetais/administração & dosagem
Convulsões/prevenção & controle
Estricnina
[Mh] Termos MeSH secundário: Animais
Biomarcadores/sangue
Glicemia/metabolismo
Modelos Animais de Doenças
Cetose
Masculino
Ratos Wistar
Tempo de Reação
Convulsões/sangue
Convulsões/induzido quimicamente
Convulsões/fisiopatologia
Sódio/sangue
Óleo de Girassol
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Blood Glucose); 0 (Plant Oils); 0 (Sunflower Oil); 9NEZ333N27 (Sodium); BH3B64OKL9 (4-Aminopyridine); H9Y79VD43J (Strychnine); WM5Z385K7T (Pentylenetetrazole)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE


  9 / 1578 MEDLINE  
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[PMID]:28259407
[Au] Autor:Gordon JL; LeBlanc SJ; Kelton DF; Herdt TH; Neuder L; Duffield TF
[Ad] Endereço:Department of Population Medicine, University of Guelph, Guelph, ON, N1G 2W1, Canada.
[Ti] Título:Randomized clinical field trial on the effects of butaphosphan-cyanocobalamin and propylene glycol on ketosis resolution and milk production.
[So] Source:J Dairy Sci;100(5):3912-3921, 2017 May.
[Is] ISSN:1525-3198
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to determine the effects of a butaphosphan-cyanocobalamin combination product (B+C) and 2 durations of propylene glycol treatment (PG; 3 versus 5 d) on ketosis resolution and early lactation milk yield. Cows from 9 freestall herds (8 in Ontario and 1 in Michigan) were tested at weekly intervals between 3 and 16 d in milk. Ketosis was defined as blood ß-hydroxybutyrate (BHB) ≥1.2 mmol/L. Ketotic cows were randomly assigned to treatment with 25 mL of B+C or 25 mL of saline placebo for 3 d and 3 or 5 d of 300 g of PG orally in a 2 × 2 factorial arrangement. Outcomes evaluated for all farms included ketosis cure (blood BHB <1.2 mmol/L at 1 wk after enrollment), maintenance of ketosis cure (blood BHB <1.2 mmol/L 1 and 2 wk after enrollment), and blood BHB concentrations at 1 and 2 wk after enrollment. Daily milk weights were collected in 3 herds. Poisson regression was used to evaluate cure and maintenance of cure, whereas repeated-measures ANOVA was used to evaluate blood BHB concentrations in the 2 wk after enrollment and average daily milk production in the 30 d after treatment. A total of 594 animals were enrolled in the study with 124 treated with B+C and 5 d of PG, 176 treated with B+C and 3 d of PG, 128 treated with saline and 5 d of PG, and 166 treated with saline and 3 d of PG. Animals with blood BHB >2.4 mmol/L at the time of enrollment were 1.7 times more likely [95% confidence interval (CI): 1.4 to 2.2] to cure and had a decrease of 0.25 ± 0.11 mmol/L blood BHB at 1 wk after enrollment if treated with 5 d of PG compared with 3 d, though this response was not seen in animals with BHB of 1.2 to 2.4 mmol/L at enrollment. Cows with blood glucose concentrations <2.2 mmol/L at enrollment produced 3.1 kg/d (95% CI: 1.3 to 5.0) more milk if treated with B+C and 3.4 kg/d (95% CI: 1.7 to 5.1) more milk if treated with 5 d of PG compared with their respective controls. This response was not seen in animals with blood glucose ≥2.2 mmol/L at enrollment and there was no interaction between treatments. These results indicate that extended PG treatment is beneficial in decreasing blood BHB concentrations in more severely affected animals. Additionally, both B+C treatment and extended PG treatment improved milk yield in animals with low blood glucose at the time of ketosis diagnosis.
[Mh] Termos MeSH primário: Cetose/veterinária
Lactação/efeitos dos fármacos
Compostos Organofosforados/farmacologia
[Mh] Termos MeSH secundário: Ácido 3-Hidroxibutírico/sangue
Animais
Bovinos
Doenças dos Bovinos/tratamento farmacológico
Combinação de Medicamentos
Feminino
Cetose/tratamento farmacológico
Leite/efeitos dos fármacos
Propilenoglicol/farmacologia
Vitamina B 12/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Organophosphorus Compounds); 0 (butaphosphan, cyanocobalamin drug combination); 6DC9Q167V3 (Propylene Glycol); P6YC3EG204 (Vitamin B 12); TZP1275679 (3-Hydroxybutyric Acid)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170306
[St] Status:MEDLINE


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[PMID]:28255778
[Au] Autor:Paquay S; Bourillon A; Pichard S; Benoist JF; de Lonlay P; Dobbelaere D; Fouilhoux A; Guffon N; Rouvet I; Labarthe F; Mention K; Touati G; Valayannopoulos V; Ogier de Baulny H; Elmaleh-Bergès M; Acquaviva-Bourdain C; Vianey-Saban C; Schiff M
[Ad] Endereço:Reference Center for Inborn Errors of Metabolism, Robert Debré University Hospital, 48 Bd Sérurier, Paris, F-75935 Cedex 19, France.
[Ti] Título:Mitochondrial acetoacetyl-CoA thiolase deficiency: basal ganglia impairment may occur independently of ketoacidosis.
[So] Source:J Inherit Metab Dis;40(3):415-422, 2017 May.
[Is] ISSN:1573-2665
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mitochondrial acetoacetyl-CoA thiolase (T2) deficiency affects ketone body and isoleucine catabolism. Neurological impairment may occur secondary to ketoacidotic episodes. However, we observed neuromotor abnormalities without ketoacidotic events in two T2-deficient families. We hypothesized that the neurological signs were related to the genetic defect and may occur independently of ketoacidotic episodes. We therefore conducted a retrospective review on a French T2-deficient patient series searching for neuromotor impairment. METHODS: In total, 26 cases were retrospectively analysed for clinical, biological and neuroimaging data. RESULTS: Neurological findings were observed for 6/26 (23%) patients. Among these, two had never experienced ketoacidotic episodes, though they developed extrapyramidal signs with putamen involvement. Two of the other four patients developed neurological abnormalities before the first ketoacidotic crisis, with putamen involvement in one case. The third patient developed extrapyramidal symptoms more than 10 years after the initial decompensation with globus pallidus involvement. The last patient developed extrapyramidal signs immediately after a severe ketoacidotic crisis with putaminal lesions. CONCLUSIONS: Most T2-deficient patients achieved normal neurodevelopment. However, on account of the role of T2 in isoleucine catabolism, these patients are potentially exposed to accumulation of toxic isoleucine-derived metabolites, which may contribute to neurological impairment. Our findings confirm previous observations that neurological symptoms in T2 deficiency may occur unrelated to ketoacidosis. The role of protein restriction as a preventive measure against neurological symptoms could not be established in this study and deserves further evaluation. Long-term follow-up data on children diagnosed by newborn screening may clarify the pathogenesis of this neurometabolic association.
[Mh] Termos MeSH primário: Acetil-CoA C-Acetiltransferase/deficiência
Acetil-CoA C-Aciltransferase/deficiência
Erros Inatos do Metabolismo dos Aminoácidos/metabolismo
Gânglios da Base/metabolismo
Cetose/metabolismo
Mitocôndrias/metabolismo
[Mh] Termos MeSH secundário: Acetil-CoA C-Aciltransferase/metabolismo
Adolescente
Adulto
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Recém-Nascido
Isoleucina/metabolismo
Corpos Cetônicos/metabolismo
Masculino
Triagem Neonatal/métodos
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ketone Bodies); 04Y7590D77 (Isoleucine); EC 2.3.1.16 (Acetyl-CoA C-Acyltransferase); EC 2.3.1.9 (Acetyl-CoA C-Acetyltransferase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE
[do] DOI:10.1007/s10545-017-0021-y



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