Base de dados : MEDLINE
Pesquisa : C18.452.394 [Categoria DeCS]
Referências encontradas : 650 [refinar]
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[PMID]:28917655
[Au] Autor:Hu Z; Chen M; Zhou H; Tharakan A; Wang X; Qiu L; Liang S; Qin X; Zhang Y; Wang W; Xu Y; Ying Z
[Ad] Endereço:Department of Endocrinology, The People's Hospital of Zhengzhou University (Henan Provincial People's Hospital), Zhengzhou, Henan 450003, China; Department of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: huziying828@126.com.
[Ti] Título:Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM .
[So] Source:Toxicology;390:100-108, 2017 Sep 01.
[Is] ISSN:1879-3185
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Exposure to ambient fine particulate matter (PM ) is associated with increased cardiometabolic morbidity and mortality. This is widely believed to be attributable to PM exposure-induced pulmonary and subsequent systemic inflammation. Tumor necrosis factor alpha (TNFα), lymphotoxin α (LTα), and lymphotoxin ß (LTß) are three homologous pro-inflammatory cytokines, each with both unique and redundant activities in inflammation. Their role in PM exposure-induced inflammation and adverse cardiometabolic effects has to be determined. METHODS AND RESULTS: LTα/TNFα/LTß triple-knockout (TNF/LT KO) and wildtype (WT) mice were exposed to concentrated ambient PM (CAP) for 5 months. Lung pathological analysis revealed that TNF/LT deficiency reduced CAP exposure-induced pulmonary inflammation. However, glucose homeostasis assessments showed that TNF/LT deficiency significantly aggravated CAP exposure-induced glucose intolerance and insulin resistance. Consistent with glucose homeostasis assessments, CAP exposure significantly increased the body weight and adiposity of TNF/LT KO but not WT mice. In contrast to its body weight effects, CAP exposure reduced food intake of WT but not TNF/LT KO mice. On the other hand, CAP exposure induced marked fat droplet accumulation in brown adipose tissues of WT mice and significantly decreased their uncoupling protein 1 (UCP1) expression, and these effects were markedly exacerbated in TNF/LT KO mice. CONCLUSION: The present study suggests that TNF/LT deficiency influences PM exposure-induced response of energy metabolism through alterations in both food intake and energy expenditure.
[Mh] Termos MeSH primário: Inativação Gênica
Transtornos do Metabolismo de Glucose/induzido quimicamente
Linfotoxina-alfa/deficiência
Linfotoxina-beta/deficiência
Obesidade/induzido quimicamente
Material Particulado/toxicidade
Pneumonia/prevenção & controle
Fator de Necrose Tumoral alfa/deficiência
[Mh] Termos MeSH secundário: Tecido Adiposo Marrom/efeitos dos fármacos
Tecido Adiposo Marrom/metabolismo
Tecido Adiposo Marrom/fisiopatologia
Tecido Adiposo Branco/efeitos dos fármacos
Tecido Adiposo Branco/metabolismo
Tecido Adiposo Branco/fisiopatologia
Adiposidade/efeitos dos fármacos
Animais
Biomarcadores/sangue
Glicemia/efeitos dos fármacos
Glicemia/metabolismo
Ingestão de Alimentos/efeitos dos fármacos
Metabolismo Energético/efeitos dos fármacos
Genótipo
Transtornos do Metabolismo de Glucose/genética
Transtornos do Metabolismo de Glucose/metabolismo
Insulina/sangue
Resistência à Insulina
Gotículas Lipídicas/efeitos dos fármacos
Gotículas Lipídicas/metabolismo
Linfotoxina-alfa/genética
Linfotoxina-beta/genética
Camundongos Endogâmicos C57BL
Camundongos Knockout
Obesidade/genética
Obesidade/metabolismo
Obesidade/fisiopatologia
Tamanho da Partícula
Fenótipo
Pneumonia/induzido quimicamente
Pneumonia/genética
Pneumonia/metabolismo
Fatores de Tempo
Fator de Necrose Tumoral alfa/genética
Proteína Desacopladora 1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Blood Glucose); 0 (Insulin); 0 (Ltb protein, mouse); 0 (Lymphotoxin-alpha); 0 (Lymphotoxin-beta); 0 (Particulate Matter); 0 (Tumor Necrosis Factor-alpha); 0 (Ucp1 protein, mouse); 0 (Uncoupling Protein 1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170918
[St] Status:MEDLINE


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[PMID]:28864535
[Au] Autor:Pepe J; Cipriani C; Sonato C; Raimo O; Biamonte F; Minisola S
[Ad] Endereço:Department of Internal Medicine and Medical Disciplines'Sapienza' University, Rome, Italy jessica.pepe@uniroma1.it.
[Ti] Título:Cardiovascular manifestations of primary hyperparathyroidism: a narrative review.
[So] Source:Eur J Endocrinol;177(6):R297-R308, 2017 Dec.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Data on cardiovascular disease in primary hyperparathyroidism (PHPT) are controversial; indeed, at present, cardiovascular involvement is not included among the criteria needed for parathyroidectomy. Aim of this narrative review is to analyze the available literature in an effort to better characterize cardiovascular involvement in PHPT. Due to physiological effects of both parathyroid hormone (PTH) and calcium on cardiomyocyte, cardiac conduction system, smooth vascular, endothelial and pancreatic beta cells, a number of data have been published regarding associations between symptomatic and mild PHPT with hypertension, arrhythmias, endothelial dysfunction (an early marker of atherosclerosis), glucose metabolism impairment and metabolic syndrome. However, the results, mainly derived from observational studies, are inconsistent. Furthermore, parathyroidectomy resulted in conflicting outcomes, which may be linked to several potential biases. In particular, differences in the methods utilized for excluding confounding co-existing cardiovascular risk factors together with differences in patient characteristics, with varying degrees of hypercalcemia, may have contributed to these discrepancies. The only meta-analysis carried out in PHPT patients, revealed a positive effect of parathyroidectomy on left ventricular mass index (a predictor of cardiovascular mortality) and more importantly, that the highest pre-operative PTH levels were associated with the greatest improvements. In normocalcemic PHPT, it has been demonstrated that cardiovascular risk factors are almost similar compared to hypercalcemic PHPT, thus strengthening the role of PTH in the cardiovascular involvement. Long-term longitudinal randomized trials are needed to determine the impact of parathyroidectomy on cardiovascular diseases and mortality in PHPT.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/etiologia
Medicina Baseada em Evidências
Hiperparatireoidismo Primário/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Doenças Cardiovasculares/epidemiologia
Doenças Cardiovasculares/prevenção & controle
Terapia Combinada/efeitos adversos
Transtornos do Metabolismo de Glucose/epidemiologia
Transtornos do Metabolismo de Glucose/etiologia
Transtornos do Metabolismo de Glucose/prevenção & controle
Seres Humanos
Hipercalcemia/etiologia
Hipercalcemia/prevenção & controle
Hiperparatireoidismo Primário/sangue
Hiperparatireoidismo Primário/cirurgia
Hiperparatireoidismo Primário/terapia
Hormônio Paratireóideo/sangue
Paratireoidectomia/efeitos adversos
Fatores de Risco
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Parathyroid Hormone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170903
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0485


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[PMID]:28851750
[Au] Autor:Báez-Ruiz A; Guerrero-Vargas NN; Cázarez-Márquez F; Sabath E; Basualdo MDC; Salgado-Delgado R; Escobar C; Buijs RM
[Ad] Endereço:Department of Physiology and Cellular BiologyBiomedical Research Institute, UNAM, DF, México.
[Ti] Título:Food in synchrony with melatonin and corticosterone relieves constant light disturbed metabolism.
[So] Source:J Endocrinol;235(3):167-178, 2017 Dec.
[Is] ISSN:1479-6805
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Circadian disruption is associated with metabolic disturbances such as hepatic steatosis (HS), obesity and type 2 diabetes. We hypothesized that HS, resulting from constant light (LL) exposure is due to an inconsistency between signals related to food intake and endocrine-driven suprachiasmatic nucleus (SCN) outputs. Indeed, exposing rats to LL induced locomotor, food intake and hormone arrhythmicity together with the development of HS. We investigated whether providing temporal signals such as 12-h food availability or driving a corticosterone plus melatonin rhythm could restore rhythmicity and prevent the metabolic disturbances under LL conditions in male rats. Discrete metabolic improvements under these separate treatments stimulated us to investigate whether the combination of hormone treatment together with mealtime restriction (12-h food during four weeks) could prevent the metabolic alterations. LL exposed arrhythmic rats, received daily administration of corticosterone (2.5 µg/kg) and melatonin (2.5 mg/kg) in synchrony or out of synchrony with their 12-h meal. HS and other metabolic alterations were importantly ameliorated in LL-exposed rats receiving hormonal treatment in synchrony with 12-h restricted mealtime, while treatment out of phase with meal time did not. Interestingly, liver bile acids, a major indication for HS, were only normalized when animals received hormones in synchrony with food indicating that disrupted bile acid metabolism might be an important mechanism for the HS induction under LL conditions. We conclude that food-elicited signals, as well as hormonal signals, are necessary for liver synchronization and that HS arises when there is conflict between food intake and the normal pattern of melatonin and corticosterone.
[Mh] Termos MeSH primário: Transtornos Cronobiológicos/complicações
Corticosterona/administração & dosagem
Fígado Gorduroso/etiologia
Métodos de Alimentação
Melatonina/administração & dosagem
Núcleo Supraquiasmático/fisiopatologia
[Mh] Termos MeSH secundário: Adiposidade/efeitos dos fármacos
Animais
Transtornos Cronobiológicos/fisiopatologia
Transtornos Cronobiológicos/prevenção & controle
Fígado Gorduroso/metabolismo
Fígado Gorduroso/prevenção & controle
Transtornos do Metabolismo de Glucose/etiologia
Transtornos do Metabolismo de Glucose/prevenção & controle
Luz/efeitos adversos
Masculino
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
JL5DK93RCL (Melatonin); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1530/JOE-17-0370


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[PMID]:28732571
[Au] Autor:Stefanaki C; Peppa M; Mastorakos G; Chrousos GP
[Ad] Endereço:1st Department of Pediatrics, Choremeio Research Laboratory, Athens University Medical School, National and Kapodistrian University of Athens, Medical School, Athens, Greece. Electronic address: cstefanaki@gmail.com.
[Ti] Título:Examining the gut bacteriome, virome, and mycobiome in glucose metabolism disorders: Are we on the right track?
[So] Source:Metabolism;73:52-66, 2017 Aug.
[Is] ISSN:1532-8600
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human gut microbiome is defined as the gene complement of the gut microbial community, measured via laboratory metagenomic techniques. It includes bacteriome, virome and mycobiome, which represent, respectively, the assemblages of bacteria, viruses and fungi, living in the human gut. Gut microbiota function as a living "organ" that interacts with the gastro-intestinal environment, provides nutrients and vitamins to the organism and transduces hormonal messages, essentially influencing the main metabolic pathways, including drug metabolism. A clear association between gut, and glucose metabolism disorders has recently emerged. Medications acting on glucose absorption in the gut, or enhancing gut hormone activity are already extensively employed in the therapy of diabetes. Moreover, the gut is characterized by immune, and autonomous neuronal features, which play a critical role in maintaining glucose metabolism homeostasis. Gut microbes respond to neuroendocrine, and immune biochemical messages, affecting the health, and behavior of the host. There is vast heterogeneity in the studies included in this review, hence a meta-analysis, or a systematic review were not applicable. In this article, we attempt to reveal the interplay between human gut microbiota physiology, and hyperglycemic states, synthesizing, and interpreting findings from human studies.
[Mh] Termos MeSH primário: Microbioma Gastrointestinal/fisiologia
Transtornos do Metabolismo de Glucose
Microbiota/fisiologia
Micobioma/fisiologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Hiperglicemia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170723
[St] Status:MEDLINE


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[PMID]:28719776
[Au] Autor:Lan VTH; Hoang LT; Linh NT; Quyen BTT
[Ad] Endereço:1 Hanoi University of Public Health, Hanoi, Vietnam.
[Ti] Título:Blood Glucose Disorders and Access to Health Care Services Among Adults Aged 30 to 69 Years in Chi Linh, Hai Duong, Vietnam.
[So] Source:Asia Pac J Public Health;29(5_suppl):45S-52S, 2017 Jul.
[Is] ISSN:1941-2479
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:Planning for control of diabetes in Vietnam needs valid information about the burden of diseases in general population. This study employed a cross-sectional design among population aged 30 to 69 years to measure the burden of type 2 diabetes and gaps in access to health care to explore the negative effects of rapid economic growth and urbanization in Chi Linh in recent years. A total of 594 adults were interviewed and had their fasting blood glucose tested. Results indicated that the prevalence of impaired fasting glycaemia was 11.8% and of diabetes was 12.1%. Only 16.8% diabetes cases detected in this study were diagnosed before, indicating a high level of unmet needs for detecting/managing diabetes in Chi Linh population. Significant associated factors with abnormal blood glucose included age and body mass index level. Without effective intervention programs for diabetes control and management, its burden will continue raising in the coming years. Chi Linh need to strengthen the diagnostic/treatment services at primary health care levels to ensure that people at early stage of raised blood pressure, raised blood glucose can be detected and provided with proper management to avoid serious complications, and to reduce hospital overload at central level.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/epidemiologia
Diabetes Mellitus Tipo 2/prevenção & controle
Transtornos do Metabolismo de Glucose/epidemiologia
Transtornos do Metabolismo de Glucose/terapia
Acesso aos Serviços de Saúde/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Idoso
Glicemia/análise
Estudos Transversais
Jejum
Feminino
Necessidades e Demandas de Serviços de Saúde
Seres Humanos
Masculino
Meia-Idade
Prevalência
Atenção Primária à Saúde/organização & administração
Vietnã/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1177/1010539517709069


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[PMID]:28667172
[Au] Autor:Subramanian L; Khan AA; Allu PKR; Kiranmayi M; Sahu BS; Sharma S; Khullar M; Mullasari AS; Mahapatra NR
[Ad] Endereço:From the Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036.
[Ti] Título:A haplotype variant of the human chromogranin A gene ( ) promoter increases CHGA expression and the risk for cardiometabolic disorders.
[So] Source:J Biol Chem;292(34):13970-13985, 2017 Aug 25.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The acidic glycoprotein chromogranin A (CHGA) is co-stored/co-secreted with catecholamines and crucial for secretory vesicle biogenesis in neuronal/neuroendocrine cells. CHGA is dysregulated in several cardiovascular diseases, but the underlying mechanisms are not well established. Here, we sought to identify common polymorphisms in the promoter and to explore the mechanistic basis of their plausible contribution to regulating CHGA protein levels in circulation. Resequencing of the promoter in an Indian population ( = 769) yielded nine single-nucleotide polymorphisms (SNPs): G-1106A, A-1018T, T-1014C, T-988G, G-513A, G-462A, T-415C, C-89A, and C-57T. Linkage disequilibrium (LD) analysis indicated strong LD among SNPs at the -1014, -988, -462, and -89 bp positions and between the -1018 and -57 bp positions. Haplotype analysis predicted five major promoter haplotypes that displayed differential promoter activities in neuronal cells; specifically, haplotype 2 (containing variant T alleles at -1018 and -57 bp) exhibited the highest promoter activity. Systematic computational and experimental analyses revealed that transcription factor c-Rel has a role in activating the promoter haplotype 2 under basal and pathophysiological conditions ( inflammation and hypoxia). Consistent with the higher promoter activity of haplotype 2, individuals carrying this haplotype had higher plasma CHGA levels, plasma glucose levels, diastolic blood pressure, and body mass index. In conclusion, these results suggest a functional role of the promoter haplotype 2 (occurring in a large proportion of the world population) in enhancing CHGA expression in haplotype 2 carriers who may be at higher risk for cardiovascular/metabolic disorders.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/genética
Cromogranina A/genética
Regulação da Expressão Gênica
Transtornos do Metabolismo de Glucose/genética
Polimorfismo de Nucleotídeo Único
Regiões Promotoras Genéticas
Proteínas Proto-Oncogênicas c-rel/metabolismo
[Mh] Termos MeSH secundário: Alelos
Doenças Cardiovasculares/sangue
Doenças Cardiovasculares/metabolismo
Linhagem Celular Tumoral
Imunoprecipitação da Cromatina
Cromogranina A/sangue
Cromogranina A/metabolismo
Biologia Computacional
Ensaio de Desvio de Mobilidade Eletroforética
Frequência do Gene
Estudos de Associação Genética
Predisposição Genética para Doença
Transtornos do Metabolismo de Glucose/sangue
Transtornos do Metabolismo de Glucose/metabolismo
Seres Humanos
Índia
Desequilíbrio de Ligação
Mutagênese Sítio-Dirigida
Mutação
Proteínas Proto-Oncogênicas c-rel/genética
Proteínas Recombinantes/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CHGA protein, human); 0 (Chromogranin A); 0 (HIVEN86A protein, human); 0 (Proto-Oncogene Proteins c-rel); 0 (Recombinant Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170702
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M117.778134


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[PMID]:28415864
[Au] Autor:Hagymási K; Egresi A; Lengyel G
[Ad] Endereço:II. Belgyógyászati Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Szentkirályi u. 46., 1088.
[Ti] Título:[Extrahepatic manifestations in chronic hepatitis C infected patients].
[Ti] Título:Extrahepaticus manifesztációk idült hepatitis C-vírus-fertozöttekben..
[So] Source:Orv Hetil;158(16):603-611, 2017 Apr.
[Is] ISSN:0030-6002
[Cp] País de publicação:Hungary
[La] Idioma:hun
[Ab] Resumo:The importance of chronic hepatitis C infection is significant. 3% of the World's population is infected. There is at least one extrahepatic manifestation in 50% of HCV patients, which makes the prognosis and mortality worse. The pathomechanisms included are cryoglobulin production, immunmechanisms, and direct viral effects. The authors summarize the main extrahepatic manifestations, as well as treatment possibilities. The aim is to draw attention to this colourful infection in order to improve the recognition in the era of the new effective direct antiviral agents. Orv. Hetil., 2017, 158(16), 603-612.
[Mh] Termos MeSH primário: Crioglobulinemia/virologia
Hepatite C Crônica/complicações
Cirrose Hepática/virologia
[Mh] Termos MeSH secundário: Crioglobulinemia/diagnóstico
Transtornos do Metabolismo de Glucose/etiologia
Seres Humanos
Linfoma de Células B/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1556/650.2017.30751


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[PMID]:28320201
[Au] Autor:Robich MP; Krafcik BM; Shah NK; Farber A; Rybin D; Siracuse JJ
[Ad] Endereço:Division of Cardiothoracic Surgery, Cardiovascular Institute, Maine Medical Center, Portland, ME, USA.
[Ti] Título:Analysis of "never events" following adult cardiac surgical procedures in the United States.
[So] Source:J Cardiovasc Surg (Torino);58(5):755-762, 2017 Oct.
[Is] ISSN:1827-191X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study was conducted to determine the risk factors, nature, and outcomes of "never events" following open adult cardiac surgical procedures. Understanding of these events can reduce their occurrence, and thereby improve patient care, quality metrics, and cost reduction. METHODS: "Never events" for patients included in the Nationwide Inpatient Sample who underwent coronary artery bypass graft, heart valve repair/replacement, or thoracic aneurysm repair between 2003-2011 were documented. These events included air embolism, catheter-based urinary tract infection (UTI), pressure ulcer, falls/trauma, blood incompatibility, vascular catheter infection, poor glucose control, foreign object retention, wrong site surgery and mediastinitis. Analysis included characterization of preoperative demographics, comorbidities and outcomes for patients sustaining never events, and multivariate analysis of predictive risk factors and outcomes. RESULTS: A total of 588,417 patients meeting inclusion criteria were identified. Of these, never events occurred in 4377 cases. The majority of events were in-hospital falls, vascular catheter infections, and complications of poor glucose control. Rates of falls, catheter based UTIs, and glucose control complications increased between 2009-2011 as compared to 2003-2008. Analysis revealed increased hospital length of stay, hospital charges, and mortality in patients who suffered a never event as compared to those that did not. CONCLUSIONS: This study establishes a baseline never event rate after cardiac surgery. Adverse patient outcomes and increased resource utilization resulting from never events emphasizes the need for quality improvement surrounding them. A better understanding of individual patient characteristics for those at risk can help in developing protocols to decrease occurrence rates.
[Mh] Termos MeSH primário: Acidentes por Quedas
Procedimentos Cirúrgicos Cardíacos/efeitos adversos
Infecções Relacionadas a Cateter/etiologia
Transtornos do Metabolismo de Glucose/etiologia
Erros Médicos
Infecções Urinárias/etiologia
Procedimentos Cirúrgicos Vasculares/efeitos adversos
[Mh] Termos MeSH secundário: Acidentes por Quedas/economia
Acidentes por Quedas/mortalidade
Idoso
Aorta Torácica/cirurgia
Procedimentos Cirúrgicos Cardíacos/economia
Procedimentos Cirúrgicos Cardíacos/mortalidade
Infecções Relacionadas a Cateter/economia
Infecções Relacionadas a Cateter/mortalidade
Infecções Relacionadas a Cateter/terapia
Ponte de Artéria Coronária/efeitos adversos
Bases de Dados Factuais
Feminino
Transtornos do Metabolismo de Glucose/economia
Transtornos do Metabolismo de Glucose/mortalidade
Transtornos do Metabolismo de Glucose/terapia
Recursos em Saúde/economia
Recursos em Saúde/utilização
Implante de Prótese de Valva Cardíaca/efeitos adversos
Preços Hospitalares
Mortalidade Hospitalar
Seres Humanos
Tempo de Internação
Modelos Logísticos
Masculino
Erros Médicos/economia
Erros Médicos/mortalidade
Meia-Idade
Análise Multivariada
Razão de Chances
Indicadores de Qualidade em Assistência à Saúde
Estudos Retrospectivos
Fatores de Risco
Fatores de Tempo
Resultado do Tratamento
Estados Unidos
Infecções Urinárias/economia
Infecções Urinárias/mortalidade
Infecções Urinárias/terapia
Procedimentos Cirúrgicos Vasculares/economia
Procedimentos Cirúrgicos Vasculares/mortalidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.23736/S0021-9509.17.09866-4


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[PMID]:28241734
[Au] Autor:Ryuk JA; Ko BS; Lee HW; Kim DS; Kang S; Lee YH; Park S
[Ad] Endereço:1 Korea Institute of Oriental Medicine, Daejeon 305-811, Korea.
[Ti] Título:Tetragonia tetragonioides (Pall.) Kuntze protects estrogen-deficient rats against disturbances of energy and glucose metabolism and decreases proinflammatory cytokines.
[So] Source:Exp Biol Med (Maywood);242(6):593-605, 2017 Mar.
[Is] ISSN:1535-3699
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Tetragonia tetragonioides (Pall.) Kuntze (TTK) and JakYakGamCho-Tang (JGT) have been used for improving women's health and treating inflammatory diseases. We determined that the long-term consumption of these herbal extracts alleviates the progression of postmenopausal symptoms in high-fat-diet fed ovariectomized (OVX) rats, and further explored the mechanisms involved. Five groups of OVX rats were fed high fat diets that were supplemented with either 2% dextrin (control), 2% TTK (70% ethanol extract), 2% JGT (water extract), 1% JGT + 1% TTK (JGTT), or 30 µg/kg body weight/day of 17ß-estradiol (positive control). After eight weeks of dietary intervention, the herbal treatments did not change the serum concentrations of 17ß-estradiol or uterine weight in control rats, but they were higher in the positive-control group. TTK rats exhibited higher daily energy expenditure, particularly fat oxidation, without modifying the energy intake than the controls. TTK lowered the fat mass but lean body mass of the abdomen and leg were increased. JGT decreased periuterine fat mass and lean body mass more than the control but the decrease was not as much as TTK. TTK resulted in substantially lower serum concentrations of the proinflammatory cytokines, tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein-1, than the control and JGT had lesser effect than TTK. Insulin resistance, determined by homeostasis model assessment estimate for assessing insulin resistance (HOMA-IR) and insulin tolerance test, was reduced in the decreasing order of control, JGT, JGTT, and TTK and the HOMA-IR of TTK was similar to the positive control. TTK, but not JGT, enhanced glucose tolerance compared with the control, although the serum insulin levels in TTK were lower compared to the control. Interestingly, the ß-cell masses were much greater in the TTK and JGTT groups than in the control, and they were comparable to the positive control. The increases in ß-cell masses in TTK and JGTT groups were associated with enhanced ß-cell proliferation and suppressed apoptosis, which was related to the decreased TNF-α and interleukin-1ß expressions. In conclusion, JGTT did not improve menopausal symptoms better than TTK itself. TTK itself prevented the OVX-induced impairments in energy, lipid, and glucose metabolism, similar to the positive control, without changing serum 17ß-estradiol levels and potentiating insulin signaling and decreasing proinflammatory cytokines. TTK may be a useful intervention to alleviate some menopausal symptoms similar to selective estrogen receptor modulators and should be investigated with further human study. Impact statement Menopause decreases the quality of life in middle-aged women and herbal remedies are sometimes used as alternatives for hormone replacement therapy, which may have detrimental side effects. Although several herbal extracts have been studied, no remedies improve all the menopausal symptoms. In this study, the 70% ethanol extract of Tetragonia tetragonioides (Pall.) Kuntze (TTK) reduced the symptoms of hot flushes and improved energy, glucose, and lipid metabolism in estrogen-deficient animals without increasing serum 17ß-estradiol levels. This extract acts like a selective estrogen receptor modulator and it may be a useful intervention for alleviating menopausal symptoms. This is the first study to show that the 70% ethanol extract of TTK has the potential to treat menopause-associated symptoms and metabolic disturbances. It may be a useful intervention for alleviating the symptoms of menopause in women if its efficacy can be confirmed in human studies.
[Mh] Termos MeSH primário: Aizoaceae
Metabolismo Energético/efeitos dos fármacos
Estrogênios/deficiência
Transtornos do Metabolismo de Glucose/tratamento farmacológico
Fitoterapia/métodos
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Aizoaceae/química
Animais
Calorimetria
Metabolismo Energético/fisiologia
Feminino
Transtornos do Metabolismo de Glucose/etiologia
Ovariectomia
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Estrogens); 0 (Plant Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE
[do] DOI:10.1177/1535370216683835


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[PMID]:28185532
[Au] Autor:Kim M; Kim M; Han JY; Lee SH; Jee SH; Lee JH
[Ad] Endereço:1 Research Center for Silver Science, Institute of Symbiotic Life-TECH, Yonsei University, Seoul, Republic of Korea.
[Ti] Título:The metabolites in peripheral blood mononuclear cells showed greater differences between patients with impaired fasting glucose or type 2 diabetes and healthy controls than those in plasma.
[So] Source:Diab Vasc Dis Res;14(2):130-138, 2017 03.
[Is] ISSN:1752-8984
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To determine differences between peripheral blood mononuclear cells and the plasma metabolites in patients with impaired fasting glucose or type 2 diabetes and healthy controls. In all, 65 nononobese patients (aged 30-70 years) with impaired fasting glucose or type 2 diabetes and 65 nonobese sex-matched healthy controls were included, and fasting peripheral blood mononuclear cell and plasma metabolomes were profiled. The diabetic or impaired fasting glucose patients showed higher circulating and peripheral blood mononuclear cell lipoprotein phospholipase A activities, high-sensitivity C-reactive protein and tumour necrosis factor-α than controls. Compared with controls, impaired fasting glucose or diabetic subjects showed increases in 11 peripheral blood mononuclear cell metabolites: six amino acids (valine, leucine, methionine, phenylalanine, tyrosine and tryptophan), l-pyroglutamic acid, two fatty acid amides containing palmitic amide and oleamide and two lysophosphatidylcholines. In impaired fasting glucose or diabetic patients, peripheral blood mononuclear cell lipoprotein phospholipase A positively associated with peripheral blood mononuclear cell lysophosphatidylcholines and circulating inflammatory markers, including tumour necrosis factor-α, high-sensitivity C-reactive protein and lipoprotein phospholipase A activities. In plasma metabolites between patients and healthy controls, we observed significant increases in only three amino acids (proline, valine and leucine) and decreases in only five lysophosphatidylcholines. This study demonstrates significant differences in the peripheral blood mononuclear cell metabolome in patients with impaired fasting glucose or diabetes compared with healthy controls. These differences were greater than those observed in the plasma metabolome. These data suggest peripheral blood mononuclear cells as a useful tool to better understand the inflammatory pathophysiology of diabetes.
[Mh] Termos MeSH primário: Glicemia/análise
Diabetes Mellitus Tipo 2/sangue
Jejum/sangue
Transtornos do Metabolismo de Glucose/sangue
Leucócitos Mononucleares/metabolismo
[Mh] Termos MeSH secundário: 1-Alquil-2-acetilglicerofosfocolina Esterase/sangue
Adulto
Idoso
Biomarcadores/sangue
Estudos de Casos e Controles
Diabetes Mellitus Tipo 2/diagnóstico
Feminino
Transtornos do Metabolismo de Glucose/diagnóstico
Seres Humanos
Mediadores da Inflamação/sangue
Leucina/sangue
Lisofosfatidilcolinas/sangue
Masculino
Metabolômica/métodos
Meia-Idade
Prolina/sangue
Valina/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (Blood Glucose); 0 (Inflammation Mediators); 0 (Lysophosphatidylcholines); 9DLQ4CIU6V (Proline); EC 3.1.1.47 (1-Alkyl-2-acetylglycerophosphocholine Esterase); EC 3.1.1.47 (PLA2G7 protein, human); GMW67QNF9C (Leucine); HG18B9YRS7 (Valine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171127
[Lr] Data última revisão:
171127
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE
[do] DOI:10.1177/1479164116678157



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