Base de dados : MEDLINE
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Referências encontradas : 377 [refinar]
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[PMID]:29288662
[Au] Autor:Zhang X; Zhang P; Gao J; Huang Q
[Ad] Endereço:Department of General Surgery, Affiliated Provincial Hospital of Anhui Medical University, Hefei, 230001, China.
[Ti] Título:Autophagy dysregulation caused by ApoM deficiency plays an important role in liver lipid metabolic disorder.
[So] Source:Biochem Biophys Res Commun;495(4):2643-2648, 2018 01 22.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Autophagy is thought to be a key mechanism in maintaining the balance of liver lipid metabolism. However, the relationship between apolipoprotein M (ApoM) and autophagy has not been reported, and the role of ApoM in triglyceride metabolism is still unclear. In this study, we investigated the correlation between ApoM and autophagy and liver triglyceride metabolism in ApoM-knockout animal and cellular models. First, we observed that spontaneous hepatic steatosis developed in the liver of adult ApoM mice, which was presented as the accumulation of large quantities of lipid droplets in hepatocytes under electron microscopy; Oil Red O staining showed significant accumulation of triglycerides. At the molecular level, the expression of lipid synthesis-associated proteins (primarily triglyceride synthesis) as well as acetyl-CoA carboxylase alpha (ACACA), fatty acid synthase (FASN) and sterol regulatory element-binding protein 1 (SREBP1) was upregulated. Moreover, lipid metabolic disorder and accumulation were accompanied by dysfunction in autophagy, which displayed predominantly as inhibition of the degradation pathway; for example, P62 protein accumulated and key proteins involved in the initiation of autophagy including ATG7, ATG5-12, Beclin1 and the LC3BII/LC3BI ratio were upregulated as a feedback response. When the autophagy dysfunction was ameliorated by the activation of autophagy pathways induced by starvation, the lipid metabolic disorder was corrected to a certain extent. This suggests that the autophagy dysfunction caused by the deficiency of ApoM is an important factor in hepatic steatosis (triglyceride accumulation). ApoM plays a key role in normal autophagy activity in the liver and thereby further regulates the metabolism of liver lipids, particularly triglycerides.
[Mh] Termos MeSH primário: Apolipoproteínas M/metabolismo
Autofagia
Fígado Gorduroso/metabolismo
Transtornos do Metabolismo dos Lipídeos/metabolismo
Fígado/metabolismo
Fígado/patologia
Triglicerídeos/metabolismo
[Mh] Termos MeSH secundário: Animais
Apolipoproteínas M/genética
Fígado Gorduroso/complicações
Fígado Gorduroso/patologia
Feminino
Transtornos do Metabolismo dos Lipídeos/complicações
Transtornos do Metabolismo dos Lipídeos/patologia
Masculino
Camundongos
Camundongos Knockout
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (ApoM protein, mouse); 0 (Apolipoproteins M); 0 (Triglycerides)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171231
[St] Status:MEDLINE


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[PMID]:28710072
[Au] Autor:Ruiz M; Labarthe F; Fortier A; Bouchard B; Thompson Legault J; Bolduc V; Rigal O; Chen J; Ducharme A; Crawford PA; Tardif JC; Des Rosiers C
[Ad] Endereço:Department of Nutrition, Université de Montréal, Montreal, Quebec, Canada.
[Ti] Título:Circulating acylcarnitine profile in human heart failure: a surrogate of fatty acid metabolic dysregulation in mitochondria and beyond.
[So] Source:Am J Physiol Heart Circ Physiol;313(4):H768-H781, 2017 Oct 01.
[Is] ISSN:1522-1539
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Heart failure (HF) is associated with metabolic perturbations, particularly of fatty acids (FAs), which remain to be better understood in humans. This study aimed at testing the hypothesis that HF patients with reduced ejection fraction display systemic perturbations in levels of energy-related metabolites, especially those reflecting dysregulation of FA metabolism, namely, acylcarnitines (ACs). Circulating metabolites were assessed using mass spectrometry (MS)-based methods in two cohorts. The main cohort consisted of 72 control subjects and 68 HF patients exhibiting depressed left ventricular ejection fraction (25.9 ± 6.9%) and mostly of ischemic etiology with ≥2 comorbidities. HF patients displayed marginal changes in plasma levels of tricarboxylic acid cycle-related metabolites or indexes of mitochondrial or cytosolic redox status. They had, however, 22-79% higher circulating ACs, irrespective of chain length ( < 0.0001, adjusted for sex, age, renal function, and insulin resistance, determined by shotgun MS/MS), which reflects defective mitochondrial ß-oxidation, and were significantly associated with levels of NH -terminal pro-B-type natriuretic peptide levels, a disease severity marker. Subsequent extended liquid chromatography-tandem MS analysis of 53 plasma ACs in a subset group from the primary cohort confirmed and further substantiated with a comprehensive lipidomic analysis in a validation cohort revealed in HF patients a more complex circulating AC profile. The latter included dicarboxylic-ACs and dihydroxy-ACs as well as very long chain (VLC) ACs or sphingolipids with VLCFAs (>20 carbons), which are proxies of dysregulated FA metabolism in peroxisomes. Our study identified alterations in circulating ACs in HF patients that are independent of biological traits and associated with disease severity markers. These alterations reflect dysfunctional FA metabolism in mitochondria but also beyond, namely, in peroxisomes, suggesting a novel mechanism contributing to global lipid perturbations in human HF. Mass spectrometry-based profiling of circulating energy metabolites, including acylcarnitines, in two cohorts of heart failure versus control subjects revealed multiple alterations in fatty acid metabolism in peroxisomes in addition to mitochondria, thereby highlighting a novel mechanism contributing to global lipid perturbations in heart failure.Listen to this article's corresponding podcast at http://ajpheart.podbean.com/e/acylcarnitines-in-human-heart-failure/.
[Mh] Termos MeSH primário: Carnitina/análogos & derivados
Ácidos Graxos/metabolismo
Insuficiência Cardíaca/sangue
Transtornos do Metabolismo dos Lipídeos/sangue
Mitocôndrias Cardíacas/metabolismo
[Mh] Termos MeSH secundário: Idoso
Carnitina/sangue
Estudos de Coortes
Feminino
Seres Humanos
Masculino
Meia-Idade
Peroxissomos/metabolismo
Esfingolipídeos/metabolismo
Volume Sistólico
Disfunção Ventricular Esquerda/sangue
Disfunção Ventricular Esquerda/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Sphingolipids); 0 (acylcarnitine); S7UI8SM58A (Carnitine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170716
[St] Status:MEDLINE
[do] DOI:10.1152/ajpheart.00820.2016


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[PMID]:28669221
[Au] Autor:Zhang Q; Xiao X; Zheng J; Li M; Yu M; Ping F; Wang Z; Qi C; Wang T; Wang X
[Ad] Endereço:Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
[Ti] Título:Maternal chromium restriction modulates miRNA profiles related to lipid metabolism disorder in mice offspring.
[So] Source:Exp Biol Med (Maywood);242(14):1444-1452, 2017 Aug.
[Is] ISSN:1535-3699
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Increasing evidence shows that maternal nutrition status has a vital effect on offspring susceptibility to obesity. MicroRNAs are related to lipid metabolism processes. This study aimed to evaluate whether maternal chromium restriction could affect miRNA expression involved in lipid metabolism in offspring. Weaning C57BL/6J mice born from mothers fed with normal control diet or chromium-restricted diet were fed for 13 weeks. The adipose miRNA expression profile was analyzed by miRNA array analysis. At 16 weeks old, pups from dams fed with chromium-restricted diet exhibit higher body weight, fat weight, and serum TC, TG levels. Six miRNAs were identified as upregulated in the RC group compared with the CC group, whereas eight miRNAs were lower than the threshold level set in the RC group. In the validated target genes of these differentially expressed miRNA, the MAPK signaling pathway serves an important role in the influence of early life chromium-restricted diet on lipid metabolism through miRNA. Long-term programming on various specific miRNA and MAPK signaling pathway may be involved in maternal chromium restriction in the adipose of female offspring. Impact statement For the first time, our study demonstrates important miRNA differences in the effect of maternal chromium restriction in offspring. These miRNAs may serve as "bridges" between the mother and the offspring by affecting the MAPK pathway.
[Mh] Termos MeSH primário: Cromo/deficiência
Perfilação da Expressão Gênica
Transtornos do Metabolismo dos Lipídeos/patologia
MicroRNAs/análise
[Mh] Termos MeSH secundário: Tecido Adiposo/patologia
Animais
Peso Corporal
Colesterol/sangue
Camundongos Endogâmicos C57BL
Análise em Microsséries
Triglicerídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MicroRNAs); 0 (Triglycerides); 0R0008Q3JB (Chromium); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE
[do] DOI:10.1177/1535370217719059


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[PMID]:28391909
[Au] Autor:Brown WV; Aberg JA; Aspry KE; Longenecker CT; Myerson M
[Ad] Endereço:Emory University School of Medicine, Atlanta, GA, USA. Electronic address: wbrow925@bellsouth.net.
[Ti] Título:JCL roundtable: Managing lipid disorders in patients with HIV.
[So] Source:J Clin Lipidol;11(1):4-11, 2017 Jan - Feb.
[Is] ISSN:1933-2874
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The HIV-AIDS epidemic has provided one of the more challenging problems in treatment of infectious diseases. As antiretroviral drugs made a very marked improvement in controlling the immunodeficiency state and patients gained in their longevity, the concern with lipid abnormalities came to the fore. The initial drugs produced a form of metabolic syndrome accompanied by very elevated plasma triglyceride concentrations. Furthermore, the drugs used to control the virus were often metabolized in a manner that interfered with lipid lowering drug therapy. The antiviral agents have improved in many respects and the experience in managing the lipid disorders has added greatly to our ability to control these problems as well. This roundtable discussion has been conducted with 4 physicians who have been involved in management of large cohorts of patients with HIV infection and who have had a special interest in reduction of vascular disease risk.
[Mh] Termos MeSH primário: Infecções por HIV/complicações
Transtornos do Metabolismo dos Lipídeos/complicações
Assistência ao Paciente/métodos
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE


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[PMID]:28288434
[Au] Autor:Smith M; Clapham L; Strauss K
[Ad] Endereço:BD Diabetes Care, The Danby Building, Edmund Halley Road, Oxford Science Park, Oxford OX4 4DQ, UK. Electronic address: mike_smith@europe.bd.com.
[Ti] Título:UK lipohypertrophy interventional study.
[So] Source:Diabetes Res Clin Pract;126:248-253, 2017 Apr.
[Is] ISSN:1872-8227
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Lipohypertrophy (LH) is one of the most common complications of insulin therapy. We conducted a prospective study in 18 UK centres to assess the impact of a targeted LH intervention on a range of clinical, biological and socio-economic parameters. METHODS: Seventy-five insulin-injecting patients were recruited randomly and were followed prospectively for 3-6months, with results compared to baseline values. Interventions included the use of an intensive education program and a switch to a 4mm pen needle. RESULTS: At all injection sites LH decreased significantly by the end of the study, either disappearing completely or shrinking by approximately 50% from its original diameter. Injections into LH decreased by more than 75% by the end. Most patients were not correctly rotating injection sites at the beginning but by the end most were, by a 5-fold margin. Only 1/3 of our subjects used the 4mm needle at the beginning of the study, however, virtually all did by study end. The mean HbA1c improved by more than 4mmol/L and there were significantly lower levels of unexpected hypoglycaemia and glucose variability. Total daily doses of insulin dropped by an average of 5.6 IU by study end. CONCLUSIONS: We believe the impressive clinical improvements seen with training to prevent LH can be achieved by wide adoption of the interventions outlined in this study.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/tratamento farmacológico
Insulina/administração & dosagem
Insulina/efeitos adversos
Transtornos do Metabolismo dos Lipídeos/induzido quimicamente
Transtornos do Metabolismo dos Lipídeos/prevenção & controle
Educação de Pacientes como Assunto
Gordura Subcutânea/patologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Hipertrofia/induzido quimicamente
Hipoglicemia/tratamento farmacológico
Injeções Subcutâneas/efeitos adversos
Masculino
Meia-Idade
Estudos Prospectivos
Autocuidado/métodos
Gordura Subcutânea/efeitos dos fármacos
Reino Unido
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Insulin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE


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[PMID]:27978938
[Au] Autor:Sun Z; Zhou JY
[Ad] Endereço:Department of Infectious Disease, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
[Ti] Título:[Mechanism of action of the SIRT1-FoxO1-AdipoR2 signaling pathway in alcoholic fatty liver disease].
[So] Source:Zhonghua Gan Zang Bing Za Zhi;24(11):877-880, 2016 Nov 20.
[Is] ISSN:1007-3418
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Long-term alcohol stimulation may inhibit the expression of silent information regulator 1 in hepatocytes, which increases the acetylation level of forkhead box transcription factor O1, reduces nuclear localization, and reduces the binding capacity of DNA sequence. This further downregulates the expression of downstream adiponectin receptor 2 and microsomal triglyceride transfer protein, causes lipid metabolism disorders and triglyceride deposition in hepatocytes by affecting adiponectin signal transduction and synthesis of very-low-density lipoprotein, and finally promotes the development of alcoholic fatty liver disease.
[Mh] Termos MeSH primário: Adiponectina
Fígado Gorduroso Alcoólico
Fatores de Transcrição Forkhead/fisiologia
Transdução de Sinais/fisiologia
Sirtuína 1
[Mh] Termos MeSH secundário: Animais
Proteínas de Transporte
Etanol
Proteína Forkhead Box O1
Hepatócitos
Seres Humanos
Transtornos do Metabolismo dos Lipídeos
Fígado
Sirtuína 1/fisiologia
Fatores de Transcrição
Triglicerídeos
Regulação para Cima/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ADIPOQ protein, human); 0 (Adiponectin); 0 (Carrier Proteins); 0 (Forkhead Box Protein O1); 0 (Forkhead Transcription Factors); 0 (Foxo1 protein, mouse); 0 (Transcription Factors); 0 (Triglycerides); 0 (microsomal triglyceride transfer protein); 3K9958V90M (Ethanol); EC 3.5.1.- (Sirtuin 1)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1007-3418.2016.11.017


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[PMID]:27960010
[Au] Autor:Bianchi S; Baronti A; Cominotto R; Bigazzi R
[Ti] Título:[Lipid metabolism abnormalities in Chronic Kidney Disease].
[Ti] Título:Le alterazioni del metabolismo lipidico nella malattia renale cronica..
[So] Source:G Ital Nefrol;33(S68), 2016 Malattie Metaboliche e Rene.
[Is] ISSN:1724-5990
[Cp] País de publicação:Italy
[La] Idioma:ita
[Ab] Resumo:Regardless of the etiology of renal disease, patients with chronic kidney disease (CKD) develop profound qualitative and quantitative lipoprotein metabolism abnormalities because of the presence of alterations in apolipoproteins, lipid transfer proteins, lipolytic enzymes, and lipoprotein receptors from the earlier stages of the disease. As renal function deteriorates, triglyceride concentrations increase and high-density lipoprotein cholesterol (HDL) concentrations decline, while levels of low- density lipoprotein (LDL) cholesterol remain in the normal range or become slightly decreased. Meanwhile, there is a progressive accumulation of the more atherogenic small dense LDL particles. In stages 4 and 5 of CKD, there is decreased concentration of apolipoprotein A-containing lipoproteins, and increased concentrations of triglyceride-rich apolipoprotein B-containing lipoproteins. Patients with nephrotic syndrome and preserved glomerular filtration rate show a higher atherogenic profile, with markedly elevated plasma cholesterol, triglyceride concentrations, and increased very low (VLDL) and low density lipoprotein (LDL), intermediate density lipoprotein (IDL) and lipoprotein(a) levels. Depressed plasma HDL cholesterol concentrations are also commonly observed in patients with nephrotic syndrome. Unless nephrotic syndrome is present, lipid abnormalities are not commonly observed when the lipid profile is measured using standard quantitative methods. In particular, total and LDL cholesterol, the most common lipid parameters used to stratify the cardiovascular risk and assess the effect of treatment with statins, are usually normal and often low. However, there is evidence that some alterations of the qualitative profile of lipoprotein are characteristic of chronic kidney disease, and probably contribute to the high rate of atherosclerotic events observed in these patients. These qualitative abnormalities include increased levels of VLDL and IDL cholesterol, small dense and oxidized LDL particles and lipoprotein(a). Moreover, HDL cholesterol is usually low and dysfunctional, not acting as protective, but paradoxically as proatherogenic particles. The lipid profile of CKD shows similar features to the metabolic syndrome and type 2 diabetes, conditions well known to predispose to kidney disease, which in turn aggravates insulin resistance and promotes atherogenic dyslipidemia.
[Mh] Termos MeSH primário: Transtornos do Metabolismo dos Lipídeos/etiologia
Insuficiência Renal Crônica/complicações
[Mh] Termos MeSH secundário: Seres Humanos
Lipoproteínas/metabolismo
Insuficiência Renal Crônica/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lipoproteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161214
[St] Status:MEDLINE


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[PMID]:27916067
[Au] Autor:Zhao M; Li GH
[Ad] Endereço:*Department of Nutrition, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
[Ti] Título:[The value of fasting plasma glucose and lipid profiles between 7 and 15 gestational weeks in the prediction of gestational diabetes mellitus].
[So] Source:Zhonghua Fu Chan Ke Za Zhi;51(11):835-839, 2016 Nov 25.
[Is] ISSN:0529-567X
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To explore the value of using fasting plasma glucose (FPG) and lipid profiles between 7 and 15 gestational weeks to predict gestational diabetes mellitus (GDM). The medical records of 2 138 pregnant women who had prenatal care in Beijing Obstetrics and Gynecology Hospital from August 2011 to February 2012 were analyzed retrospectively. According to results of the oral glucose tolerance tests, women were devided into the GDM group ( =240) and the normal group ( 1 898). Maternal characteristics, FPG and lipid levels between 7 and 15 gestational weeks were compared between the two groups. Logistic regression analysis and receiver operator characteristics(ROC) curve were used in the analysis. Potential markers for the prediction of GDM included total cholesterol, triglyceride (TG) , low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratios (LDL-C/HDL-C) , triglyceride to high-density lipoprotein cholesterol ratios (TG/HDL-C) and FPG. After adjustment of confounding factors, age ( 1.046, 95% 1.003-1.090), pre- pregnancy body mass index ( 1.104, 95% 1.049-1.161), gravidity>3 ( 1.768, 95% 1.071-2.920), FPG ( 8.137, 95% 5.412-12.236), TG ( 1.460, 95% 1.148-1.858) were independently associated with the risk of developing GDM. Equation, P =1/{1+exp[-(-16.542+0.045×age+0.103×pre-pregnancy body mass index+0.551×gravidity>3+2.110×FPG+0.372×TG)]}, was constructed by the logistic regression analysis. Sensitivity (67.5%) and specificity (70.5%) were determined by the calculated risk score, with a cut-off value of 0.11 (area under the curve: 0.751, 95% 0.718-0.783, 0.001). FPG and TG, together with clinical characteristics may have a better predictive value for the risk of GDM.
[Mh] Termos MeSH primário: Glicemia/metabolismo
Colesterol/sangue
Diabetes Gestacional/diagnóstico
Jejum/sangue
Transtornos do Metabolismo dos Lipídeos/complicações
Lipídeos/análise
Triglicerídeos/sangue
[Mh] Termos MeSH secundário: Adulto
Índice de Massa Corporal
HDL-Colesterol/sangue
LDL-Colesterol/sangue
Diabetes Gestacional/sangue
Diabetes Gestacional/epidemiologia
Feminino
Teste de Tolerância a Glucose
Seres Humanos
Transtornos do Metabolismo dos Lipídeos/epidemiologia
Lipoproteínas HDL/sangue
Gravidez
Primeiro Trimestre da Gravidez
Segundo Trimestre da Gravidez
Curva ROC
Estudos Retrospectivos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Cholesterol, HDL); 0 (Cholesterol, LDL); 0 (Lipids); 0 (Lipoproteins, HDL); 0 (Triglycerides); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0529-567X.2016.11.007


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[PMID]:27865164
[Au] Autor:Wang N; Zhang J; Wu Y; Liu J; Liu L; Guo X
[Ad] Endereço:Department of Medicine, Tsinghua University Hospital, Beijing 100084, China.
[Ti] Título:Metformin improves lipid metabolism disorders through reducing the expression of microsomal triglyceride transfer protein in OLETF rats.
[So] Source:Diabetes Res Clin Pract;122:170-178, 2016 Dec.
[Is] ISSN:1872-8227
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This study aimed to investigate the role of MTP on lipid metabolism disorders in insulin-resistant rats and the potential mechanism through which metformin can improve lipid metabolism disorders. METHODS: 30 OLETF rats served as research subjects and 18 LETO rats of the same strain served as the control group (LETO group). After the first oral glucose tolerance test (at 8-week-old), 6 rats were randomly killed from each group. The remaining 24 OLETF rats were randomly divided into untreated group (OLETF group) and treated group (OLETF/M group, cured with metformin). By the end of the 10th and 20th week of treatment, MTP in the liver was measured for all rats in the study. RESULTS: All OLETF rats exhibited diabetic phenotypes at 18-week-old, with their triglyceride level higher than in LETO rats at the same age. In OLETF rats, MTP level in the liver was higher than in LETO rats at 18-week-old, and the difference was significant at 28-week-old [(13.79±1.47) vs. (8.20±1.14), p<0.05]. Treatment with metformin for 20weeks decreased triglyceride [(1.06±0.23) vs. (2.20±0.62) mmol/L, p<0.05] and total cholesterol [(1.90±0.19) vs. (2.36±0.14) mmol/L, p<0.05] in OLETF rats. Metformin also decreased MTP level in the liver [(7.65±1.31) vs. (13.79±1.47), p<0.01]. CONCLUSIONS: MTP may be associated with the lipid metabolism disorder in OLETF rats and metformin could improve lipid metabolism through reducing the expression of MTP.
[Mh] Termos MeSH primário: Proteínas de Transporte/biossíntese
Diabetes Mellitus Experimental/tratamento farmacológico
Diabetes Mellitus Tipo 2/tratamento farmacológico
Transtornos do Metabolismo dos Lipídeos/tratamento farmacológico
Metabolismo dos Lipídeos/efeitos dos fármacos
Metformina/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Western Blotting
Proteínas de Transporte/efeitos dos fármacos
Diabetes Mellitus Experimental/metabolismo
Diabetes Mellitus Tipo 2/metabolismo
Hipoglicemiantes/uso terapêutico
Transtornos do Metabolismo dos Lipídeos/genética
Transtornos do Metabolismo dos Lipídeos/metabolismo
Masculino
Ratos
Ratos Endogâmicos OLETF
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carrier Proteins); 0 (Hypoglycemic Agents); 0 (microsomal triglyceride transfer protein); 9100L32L2N (Metformin)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170117
[Lr] Data última revisão:
170117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161120
[St] Status:MEDLINE


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[PMID]:27846448
[Au] Autor:Turkgeldi E; Yagmur H; Seyhan A; Urman B; Ata B
[Ad] Endereço:Dept. of Obstetrics and Gynecology, Koc University Hospital, Turkey.
[Ti] Título:Short and long term outcomes of children conceived with assisted reproductive technology.
[So] Source:Eur J Obstet Gynecol Reprod Biol;207:129-136, 2016 Dec.
[Is] ISSN:1872-7654
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Despite their wide and global use, possible short and long-term effects of fertility treatments on children is not well-established. In this review, birth defects and perinatal complications and their relationship with assisted reproductive technology (ART), along with long-term effects of ART on cardiovascular system, metabolism, behavior, cognitive skills, and childhood cancers are discussed. Children conceived through ART are at increased risk for birth defects and perinatal complications such as preterm delivery, low birth weight and small for gestational age. Parental characteristics, underlying infertility etiology and ART procedures themselves may contribute to this. The long-term effects of ART are difficult to establish. Studies so far report that ART children have normal social, emotional, cognitive, and motor functions. Likewise, despite some minor inconsistencies in some studies, they do not seem to be at increased risk for childhood cancers. However, there are a number of studies that imply vascular system may be adversely affected by ART and its possible consequences should be further investigated with follow up studies. Large scale studies with long-term follow up periods are required to determine the effects of ART on conceived children.
[Mh] Termos MeSH primário: Anormalidades Congênitas/etiologia
Retardo do Crescimento Fetal/etiologia
Infertilidade Feminina/terapia
Infertilidade Masculina/terapia
Nascimento Prematuro/etiologia
Técnicas de Reprodução Assistida/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Anormalidades Congênitas/epidemiologia
Feminino
Retardo do Crescimento Fetal/epidemiologia
Transtornos do Metabolismo de Glucose/epidemiologia
Transtornos do Metabolismo de Glucose/etiologia
Seres Humanos
Recém-Nascido de Baixo Peso
Recém-Nascido
Recém-Nascido Pequeno para a Idade Gestacional
Infertilidade Feminina/fisiopatologia
Infertilidade Masculina/fisiopatologia
Transtornos do Metabolismo dos Lipídeos/epidemiologia
Transtornos do Metabolismo dos Lipídeos/etiologia
Masculino
Gravidez
Nascimento Prematuro/epidemiologia
Risco
Doenças Vasculares/epidemiologia
Doenças Vasculares/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170414
[Lr] Data última revisão:
170414
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161116
[St] Status:MEDLINE



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