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Pesquisa : C18.654.521.500 [Categoria DeCS]
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  1 / 5906 MEDLINE  
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[PMID]:29446585
[Au] Autor:Tarmaeva IY; Hanhareev SS; Bogdanova OG
[Ti] Título:[Assessment of nutrition of students of educational institutions of the various type].
[So] Source:Gig Sanit;95(12):1213-6, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Among the risk factors that have priority in shaping the health of the population, a leading place is held by a rational nutrition. Presented results indicate to the absence of a stable group eating regularly, with the rational regularity and having all the necessary meals and the recommended food set. In the population of the adult people of the city of Irkutsk there is revealed the role of the nutritional factor in the formation of morbidity rate level of the adult population. It was found that the risk of diseases of the circulatory system accounted of 2.5 (95% CI: 2.1-3.6), for infectious and parasitic diseases - 2.4 (95% CI: 1.7-3.5), for the endocrine system - 2.2 (95% CI: 1.4-3.4), andfor the urinary system - 2.3 (95% CI: 1,7-3,0).
[Mh] Termos MeSH primário: Doenças Cardiovasculares/epidemiologia
Doenças Transmissíveis/epidemiologia
Deficiências Nutricionais
Comportamento Alimentar
Necessidades Nutricionais
Estado Nutricional
[Mh] Termos MeSH secundário: Adulto
Deficiências Nutricionais/epidemiologia
Deficiências Nutricionais/etiologia
Comportamento Alimentar/fisiologia
Comportamento Alimentar/psicologia
Feminino
Disparidades nos Níveis de Saúde
Seres Humanos
Masculino
Saúde Pública/métodos
Saúde Pública/estatística & dados numéricos
Fatores de Risco
Sibéria/epidemiologia
Estudantes/estatística & dados numéricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE


  2 / 5906 MEDLINE  
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[PMID]:29446273
[Au] Autor:Boyarskaya LA; Vil'ms EA; Turchaninov DV; Bogdashin IV; Erofeev YV
[Ti] Título:[Hygienic substantiation of application of functional dairy products in the prevention of macro- and micronutrient deficiency].
[So] Source:Gig Sanit;95(11):1095-9, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Based on the study of actual nutrition and availability of macroelements there was found that adult population of the city of Omsk was established to refer to the group at risk for the development of micronutrient deficiency associated with low content of a set of essential elements (copper, zinc, calcium, selenium) in the ration, being prior for correction.There was executed the hygienic substantiation developed the fermented acid milk bioproduct of a functional purpose "Bifidin" enriched with micronutrients, prior for the population of the Omsk region. Introduction of this bio-product into the ration allows to effectively correct disorders of the mineral status, that was manifested in a decline in the proportion of patients with insufficiency of calcium (from 37.9 to 24.1%; p = 0.013), copper (from 51.7 to 25.9%; p = 0.004), selenium (from 96.6 to 84.5%; p = 0.026), zinc (from 58.6 to 48.3% of the subjects; p = 0.264). Upon the completion of the prophylactic course (intake "Bifidin" of 200 ml for 60 days), there was noted the gain in the concentration in hair: calcium (by 24.4%; p=0.441), zinc (by 8.0%; p=0.0008), copper (by 8.8%; p < 0.001), selenium (by 41.5%; p < 0.001). There was established the efficacy of the use of bio-product "Bifidin" enriched with micronutrients for the improvement of the structure of nutrition and element status of the adult population of the city of Omsk. There was justified the extensive use of dairy products enriched with micronutrients both for the reduction of the prevalence of microelementoses and the improvement of the nutritional status.
[Mh] Termos MeSH primário: Laticínios
Deficiências Nutricionais
Suplementos Nutricionais
Comportamento Alimentar
Micronutrientes/análise
Oligoelementos/análise
[Mh] Termos MeSH secundário: Adulto
Deficiências Nutricionais/diagnóstico
Deficiências Nutricionais/epidemiologia
Deficiências Nutricionais/prevenção & controle
Feminino
Cabelo/química
Seres Humanos
Masculino
Necessidades Nutricionais/fisiologia
Estado Nutricional
Serviços Preventivos de Saúde/métodos
Sibéria/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Micronutrients); 0 (Trace Elements)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE


  3 / 5906 MEDLINE  
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[PMID]:29431323
[Au] Autor:Tarmaeva IY; Efimova NV; Baglushkina SY
[Ti] Título:[Hygienic estimation of the nutrition and the risk of morbidity associated with its violation].
[So] Source:Gig Sanit;95(9):868-72, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Among risk factors possessing a main importance in the shaping of theA public health the leading place is featured to the rational nutrition. Presented results testify to the absence of stable group in the adult population of Irkutsk who eats regularly, with a rational multiplicity and having all essential meal reception and the recommended food package. There was revealed the role of nutrition in shaping of morbidity rate in the adult population. The risk of circulatory diseases was established to account of 2.5 (95% CI 2.1-3.6), the infectious and parasitic diseases - 2.4 (95% CI 1.7-3.5), the endocrine system - 2,2 (95% CI 1.4-3.4), and urinary system - 2.3 (95% CI 1.7 to 3.0).
[Mh] Termos MeSH primário: Deficiências Nutricionais/epidemiologia
Comportamento Alimentar
Estado Nutricional
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Doenças Cardiovasculares/epidemiologia
Doenças Transmissíveis/epidemiologia
Doenças do Sistema Endócrino/epidemiologia
Feminino
Seres Humanos
Lactente
Masculino
Necessidades Nutricionais
Medição de Risco
Fatores de Risco
Sibéria/epidemiologia
Doenças Urológicas/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


  4 / 5906 MEDLINE  
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[PMID]:29424210
[Au] Autor:Dotsenko VA; Kononenko IA; Mosiychuk LV; Argunova EV; Dolotov SA; Sirotkin OG
[Ti] Título:[Features of consumption of vitamins and foods enriched with biologically active substances by Petersburgers].
[So] Source:Gig Sanit;95(5):479-83, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Purpose. To study and evaluate the use of vitamins and products enriched with biologically active substances by the residents of St. Petersburg. The study was conducted with the use of the questionnaire survey method of 1200 Petersburgers. Results. A third of residents (35.5 per cent) never used enriched food products in nutrition. The majority of St. Petersburgers (59.3%) when cooking do not use iodized salt or do it rarely. While the use of salt increases with the age. Inclusion of vitamins in the diet fails to be widely distributed among the citizens: monthly they are used by only 20.3% of citizen, 2 times a year - 28.2% and only during illness - 17.7%. One third of the population (33.8 percent) never takes vitamins in the form of tablets, syrups, solutions, etc. Conclusion. The analysis indicates the need to improve the nutrition of Petersburgers to reduce risk factors for diseases by improving health literacy in organized units for healthy nutrition on the base of Health Centers or clinics in St. Petersburg.
[Mh] Termos MeSH primário: Deficiências Nutricionais
Alimentos Fortificados/utilização
Valor Nutritivo
[Mh] Termos MeSH secundário: Adulto
Idoso
Deficiências Nutricionais/epidemiologia
Deficiências Nutricionais/prevenção & controle
Feminino
Seres Humanos
Masculino
Meia-Idade
Estado Nutricional
Saúde Pública/métodos
Saúde Pública/estatística & dados numéricos
Federação Russa/epidemiologia
Fatores Socioeconômicos
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE


  5 / 5906 MEDLINE  
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[PMID]:29412546
[Au] Autor:Kolomiets ND; Mokhort TV; Fedorenko EV; Mokhort EG; Petrenko SV
[Ti] Título:[The problem of iodine deficiency and its solution in the republic of Belarus].
[So] Source:Gig Sanit;95(5):417-21, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The problem of iodine deficiency is relevant to the Republic of Belarus. It's confirmed by virtually commonly found geophysical iodine deficiency in soils and waters. Data on iodine deficiency initiated the development of a state strategy for the elimination of iodine deficiency in the population. This strategy determined the mandatory use of iodized salt only in the country in the food industry and catering as the main event for the elimination of iodine deficiency. The aim of this work was a comprehensive evaluation of the results of the implementation of the strategy for elimination of iodine deficiency among the population of the Republic of Belarus. Medical monitoring of the assessment of the efficacy showed the decrease in the incidence of simple non-toxic goiter in adolescents from 1215,23 per 100,000 population in 1998 to 341,25 in 2013 (3.6 times), and indices ofprimary morbidity rate in children fell by 2.9 times. Over the period from 1998 primary morbidity rate of simple nontoxic goiter decreased significantly in adults from 379.9 to 31,71 people per 100,000 of the population in 2013 respectively (almost 12 times). Data of the assessment of ioduria in Belarus indicate that 89.2% of children enrolled in the study have iodine excretion of more than 100 pg/L. Thus, in the Republic of Belarus there was achieved the level of an adequate intake of iodine with foodstuffs. This model ofprevention of iodine deficiency, as well as the traditional approach based on the adoption of the law, is a versatile and cost-effective mode.
[Mh] Termos MeSH primário: Deficiências Nutricionais
Iodo/farmacologia
Cloreto de Sódio na Dieta/farmacologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Deficiências Nutricionais/epidemiologia
Deficiências Nutricionais/etiologia
Deficiências Nutricionais/prevenção & controle
Feminino
Seres Humanos
Iodo/análise
Iodo/deficiência
Masculino
Prevalência
Serviços Preventivos de Saúde/métodos
Serviços Preventivos de Saúde/organização & administração
República da Bielorrússia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sodium Chloride, Dietary); 0 (iodized salt); 9679TC07X4 (Iodine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE


  6 / 5906 MEDLINE  
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[PMID]:29189196
[Au] Autor:Diana A; Haszard JJ; Purnamasari DM; Nurulazmi I; Luftimas DE; Rahmania S; Nugraha GI; Erhardt J; Gibson RS; Houghton L
[Ad] Endereço:1Faculty of Medicine,Universitas Padjadjaran,Jln. Prof. Eijkman no. 38, Bandung 40161, West Java,Indonesia.
[Ti] Título:Iron, zinc, vitamin A and selenium status in a cohort of Indonesian infants after adjusting for inflammation using several different approaches.
[So] Source:Br J Nutr;118(10):830-839, 2017 Nov.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Inflammation confounds the interpretation of several micronutrient biomarkers resulting in estimates that may not reflect the true burden of deficiency. We aimed to assess and compare the micronutrient status of a cohort of Indonesian infants (n 230) at aged 6, 9 and 12 months by ignoring inflammation (unadjusted) and adjusting four micronutrient biomarkers for inflammation with C-reactive protein (CRP) and α-1-glycoprotein (AGP) using the following methods: (1) arithmetic correction factors with the use of a four-stage inflammation model; and (2) regression modelling. Prevalence of infants with any inflammation (CRP>5 mg/l and/or AGP>1 g/l) was about 25% at each age. Compared with unadjusted values, regression adjustment at 6, 9 and 12 months generated the lowest (P50 % across all ages. In conclusion, without inflammation adjustment, Fe deficiency was grossly under-estimated and vitamin A and Zn deficiency over-estimated, highlighting the importance of correcting for the influence of such, before implementing programmes to alleviate micronutrient malnutrition. However, further work is needed to validate the proposed approaches with a particular focus on assessing the influence of varying degrees of inflammation (i.e. recurrent acute infections and low-grade chronic inflammation) on each affected nutrient biomarker.
[Mh] Termos MeSH primário: Deficiências Nutricionais/sangue
Inflamação/sangue
Ferro/sangue
Estado Nutricional
Selênio/sangue
Vitamina A/sangue
Zinco/sangue
[Mh] Termos MeSH secundário: Anemia Ferropriva/sangue
Anemia Ferropriva/epidemiologia
Biomarcadores/sangue
Proteína C-Reativa/metabolismo
Estudos de Coortes
Estudos Transversais
Deficiências Nutricionais/epidemiologia
Feminino
Ferritinas/sangue
Seres Humanos
Indonésia/epidemiologia
Lactente
Inflamação/complicações
Inflamação/epidemiologia
Ferro/deficiência
Masculino
Micronutrientes/sangue
Orosomucoide/metabolismo
Prevalência
Proteínas de Ligação ao Retinol/metabolismo
Selênio/deficiência
Deficiência de Vitamina A/sangue
Deficiência de Vitamina A/epidemiologia
Zinco/deficiência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Micronutrients); 0 (Orosomucoid); 0 (Retinol-Binding Proteins); 11103-57-4 (Vitamin A); 9007-41-4 (C-Reactive Protein); 9007-73-2 (Ferritins); E1UOL152H7 (Iron); H6241UJ22B (Selenium); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517002860


  7 / 5906 MEDLINE  
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[PMID]:28976866
[Au] Autor:Saly DL; Brewster UC; Sze GK; Louis ED; Shirali AC
[Ad] Endereço:From the Departments of Internal Medicine (D.L.S.), Radiology (G.K.S.), and Neurology (E.D.L.) and the Section of Nephrology (U.C.B., A.C.S.), Yale School of Medicine, New Haven, CT.
[Ti] Título:An Element of Unsteadiness.
[So] Source:N Engl J Med;377(14):1379-1385, 2017 Oct 05.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Cobre/deficiência
Deficiências Nutricionais/diagnóstico
Transtornos Neurológicos da Marcha/etiologia
Sulfato de Zinco/efeitos adversos
Zinco/farmacologia
[Mh] Termos MeSH secundário: Cobre/metabolismo
Cobre/uso terapêutico
Deficiências Nutricionais/induzido quimicamente
Deficiências Nutricionais/complicações
Seres Humanos
Falência Renal Crônica/complicações
Falência Renal Crônica/terapia
Imagem por Ressonância Magnética
Meia-Idade
Diálise Peritoneal
Medula Espinal/diagnóstico por imagem
Sulfato de Zinco/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; CLINICAL CONFERENCE; JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Nm] Nome de substância:
7733-02-0 (Zinc Sulfate); 789U1901C5 (Copper); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMcps1701934


  8 / 5906 MEDLINE  
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[PMID]:28855418
[Au] Autor:Cao L; Zhang L; Zeng H; Wu RT; Wu TL; Cheng WH
[Ad] Endereço:Departments of Food Science, Nutrition and Health Promotion and.
[Ti] Título:Analyses of Selenotranscriptomes and Selenium Concentrations in Response to Dietary Selenium Deficiency and Age Reveal Common and Distinct Patterns by Tissue and Sex in Telomere-Dysfunctional Mice.
[So] Source:J Nutr;147(10):1858-1866, 2017 Oct.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The hierarchies of tissue selenium distribution and selenotranscriptomes are thought to critically affect healthspan and longevity. We determined selenium status and selenotranscriptomes in response to long-term dietary selenium deficiency and age in tissues of male and female mice. Weanling telomerase RNA component knockout C57BL/6 mice were fed a selenium-deficient (0.03 mg Se/kg) Torula yeast-based AIN-93G diet or a diet supplemented with sodium selenate (0.15 mg Se/kg) until age 18 or 24 mo. Plasma, hearts, kidneys, livers, and testes were collected to assay for selenotranscriptomes, selected selenoproteins, and tissue selenium concentrations. Data were analyzed with the use of 2-factor ANOVA (diet × age) in both sexes. Dietary selenium deficiency decreased ( ≤ 0.05) selenium concentrations (65-72%) and glutathione peroxidase (GPX) 3 (82-94%) and selenoprotein P (SELENOP) (17-41%) levels in the plasma of both sexes of mice and mRNA levels (9-68%) of 4, 4, and 12 selenoproteins in the heart, kidney, and liver of males, respectively, and 5, 16, and 14 selenoproteins, respectively, in females. Age increased selenium concentrations and SELENOP levels (27% and 30%, respectively; ≤ 0.05) in the plasma of males only but decreased (12-46%; < 0.05) mRNA levels of 1, 5, and 13 selenoproteins in the heart, kidney, and liver of males, respectively, and 6, 5, and 0 selenoproteins, respectively, in females. Among these mRNAs, selenoprotein H ( ), selenoprotein M ( ), selenoprotein W ( ), methionine- -sulfoxide reductase 1 ( ), , , thioredoxin reductase 1 ( ), , selenoprotein S ( ), selenoprotein F ( ), and selenoprotein O ( ) responded in parallel to dietary selenium deficiency and age in ≥1 tissue or sex, or both. Dietary selenium deficiency upregulated (40-160%; ≤ 0.05) iodothyronine deiodinase 2 ( ) and selenoprotein N ( ) in the kidneys of males. Age upregulated (11-44%; < 0.05) in the kidneys of males, selenoprotein K ( ) and selenoprotein I ( ) in the kidneys of females, and and in the testes. These results illustrate tissue-specific sexual dimorphisms of selenium status and selenotranscriptomes because of dietary selenium deficiency and age.
[Mh] Termos MeSH primário: Rim/metabolismo
Fígado/metabolismo
Miocárdio/metabolismo
Selênio/deficiência
Selenoproteínas/metabolismo
Telômero
Testículo/metabolismo
[Mh] Termos MeSH secundário: Fatores Etários
Animais
Deficiências Nutricionais/sangue
Deficiências Nutricionais/metabolismo
Dieta
Feminino
Perfilação da Expressão Gênica
Glutationa Peroxidase/metabolismo
Coração
Longevidade
Masculino
Camundongos Endogâmicos C57BL
Camundongos Knockout
Oxirredutases/metabolismo
RNA Mensageiro/metabolismo
Selênio/metabolismo
Selenoproteínas/sangue
Fatores Sexuais
Telomerase/genética
Telomerase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Messenger); 0 (Selenoproteins); EC 1.- (Oxidoreductases); EC 1.11.1.9 (Glutathione Peroxidase); EC 2.7.7.49 (Telomerase); H6241UJ22B (Selenium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.3945/jn.117.247775


  9 / 5906 MEDLINE  
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[PMID]:28814533
[Au] Autor:Zhou JC; Zheng S; Mo J; Liang X; Xu Y; Zhang H; Gong C; Liu XL; Lei XG
[Ad] Endereço:Molecular Biology Laboratory, Shenzhen Center for Chronic Disease Control, Shenzhen Guangdong, China; xl20@cornell.edu jichangzhou@msn.com.
[Ti] Título:Dietary Selenium Deficiency or Excess Reduces Sperm Quality and Testicular mRNA Abundance of Nuclear Glutathione Peroxidase 4 in Rats.
[So] Source:J Nutr;147(10):1947-1953, 2017 Oct.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Glutathione peroxidase (GPX) 4 and selenoprotein P (SELENOP) are abundant, and several variants are expressed in the testis. We determined the effects of dietary selenium deficiency or excess on sperm quality and expressions of GPX4 and SELENOP variants in rat testis and liver. After weaning, male Sprague-Dawley rats were fed a Se-deficient basal diet (BD) for 5 wk until they were 9 wk old [mean ± SEM body weight (BW) = 256 ± 5 g]. They were then fed the BD diet alone (deficient) or with 0.25 (adequate), 3 (excess), or 5 (excess) mg Se/kg for 4 wk. Testis, liver, blood, and semen were collected to assay for selenoprotein mRNA and protein abundances, selenium concentration, GPX activity, 8-hydroxy-deoxyguanosine concentration, and sperm quality. Dietary selenium supplementations elevated ( < 0.05) tissue selenium concentrations and GPX activities. Compared with those fed BD + 0.25 mg Se/kg, rats fed BD showed lower ( < 0.05) BW gain (86%) and sperm density (57%) but higher ( < 0.05) plasma 8-hydroxy-deoxyguanosine concentrations (189%), and nonprogressive sperm motility (4.4-fold). Likewise, rats fed BD + 5 mg Se/kg had ( = 0.06) lower BW gain and higher (1.9-fold) sperm deformity rates than those in the selenium-adequate group. Compared with the selenium-adequate group, dietary selenium deficiency (BD) or excess (BD + 3 or 5 mg Se/kg) resulted in 45-77% lower ( < 0.05) nuclear ( ) mRNA abundance in the testis. Rats fed BD had lower ( < 0.05) mRNA levels of 2 variants in both testis and liver than those in the other groups. Testicular SELENOP was 155-170% higher ( < 0.05) in rats fed BD + 5 mg Se/kg and hepatic c/mGPX4 was 13-15% lower ( < 0.05) in rats fed BD than in the other groups. The mRNA abundance of rat testicular nGPX4 responded to dietary selenium concentrations in similar ways to sperm parameters and may be used as a sensitive marker to assess appropriate Se status for male function.
[Mh] Termos MeSH primário: Dieta
Glutationa Peroxidase/metabolismo
Transtornos Nutricionais/complicações
Selênio/deficiência
Selenoproteína P/metabolismo
Espermatozoides
Testículo/metabolismo
[Mh] Termos MeSH secundário: Animais
Deficiências Nutricionais/sangue
Deficiências Nutricionais/complicações
Deficiências Nutricionais/metabolismo
Desoxiguanosina/análogos & derivados
Desoxiguanosina/sangue
Fígado/metabolismo
Masculino
Transtornos Nutricionais/sangue
Transtornos Nutricionais/metabolismo
RNA Mensageiro/metabolismo
Ratos Sprague-Dawley
Selênio/sangue
Selênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Messenger); 0 (Selenoprotein P); 88847-89-6 (8-oxo-7-hydrodeoxyguanosine); EC 1.11.1.12 (phospholipid-hydroperoxide glutathione peroxidase); EC 1.11.1.9 (Glutathione Peroxidase); G9481N71RO (Deoxyguanosine); H6241UJ22B (Selenium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.3945/jn.117.252544


  10 / 5906 MEDLINE  
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[PMID]:28768838
[Au] Autor:Lozada LE; Desai A; Kevala K; Lee JW; Kim HY
[Ad] Endereço:Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD; and.
[Ti] Título:Perinatal Brain Docosahexaenoic Acid Concentration Has a Lasting Impact on Cognition in Mice.
[So] Source:J Nutr;147(9):1624-1630, 2017 Sep.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Premature infants are deprived of prenatal accumulation of brain docosahexaenoic acid [DHA (22:6n-3)], an omega-3 fatty acid [ω-3 FA (n-3 FA)] important for proper development of cognitive function. The resulting brain DHA deficit can be reversed by ω-3 FA supplementation. The objective was to test whether there is a critical period for providing ω-3 FA to correct cognitive deficits caused by developmental ω-3 FA deprivation in mice. Twelve timed-pregnant mice [embryonic day 14 (E14), C57/BL6NCr] were fed an ω-3 FA-deficient diet containing 0.04% α-linolenic acid [ALA (18:3n-3)], and their offspring were fed the same deficient diet (Def group) or changed to an ω-3 FA-adequate diet containing 3.1% ALA at 3 wk, 2 mo, or 4 mo of age. In parallel, 3 E14 pregnant mice were fed the adequate diet and their offspring were fed the same diet (Adeq group) throughout the experiment. Brain FA composition, learning and memory, and hippocampal synaptic protein expression were evaluated at 6 mo by gas chromatography, the Morris water maze test, and western blot analysis, respectively. Maternal dietary ω-3 FA deprivation decreased DHA by >50% in the brain of their offspring at 3 wk of age. The Def group showed significantly worse learning and memory at 6 mo than those groups fed the adequate diet. These pups also had decreased hippocampal expression of postsynaptic density protein 95 (43% of Adeq group), Homer protein homolog 1 (21% of Adeq group), and synaptosome-associated protein of 25 kDa (64% of Adeq group). Changing mice to the adequate diet at 3 wk, 2 mo, or 4 mo of age restored brain DHA to the age-matched adequate concentration. However, deficits in hippocampal synaptic protein expression and spatial learning and memory were normalized only when the diet was changed at 3 wk. Developmental deprivation of brain DHA by dietary ω-3 FA depletion in mice may have a lasting impact on cognitive function if not corrected at an early age.
[Mh] Termos MeSH primário: Encéfalo/efeitos dos fármacos
Cognição/efeitos dos fármacos
Deficiências Nutricionais/tratamento farmacológico
Ácidos Docosa-Hexaenoicos/administração & dosagem
Recém-Nascido Prematuro
Aprendizagem em Labirinto/efeitos dos fármacos
Memória/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Encéfalo/crescimento & desenvolvimento
Encéfalo/metabolismo
Deficiências Nutricionais/complicações
Dieta
Gorduras na Dieta/administração & dosagem
Gorduras na Dieta/farmacologia
Gorduras na Dieta/uso terapêutico
Proteína 4 Homóloga a Disks-Large
Ácidos Docosa-Hexaenoicos/deficiência
Ácidos Docosa-Hexaenoicos/farmacologia
Ácidos Docosa-Hexaenoicos/uso terapêutico
Feminino
Guanilato Quinases/metabolismo
Proteínas de Arcabouço Homer/metabolismo
Seres Humanos
Lactente
Recém-Nascido Prematuro/crescimento & desenvolvimento
Recém-Nascido Prematuro/metabolismo
Fenômenos Fisiológicos da Nutrição Materna
Proteínas de Membrana/metabolismo
Camundongos
Gravidez
Proteína 25 Associada a Sinaptossoma/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Fats); 0 (Disks Large Homolog 4 Protein); 0 (Dlg4 protein, mouse); 0 (Homer Scaffolding Proteins); 0 (Homer1 protein, mouse); 0 (Membrane Proteins); 0 (Snap25 protein, mouse); 0 (Synaptosomal-Associated Protein 25); 25167-62-8 (Docosahexaenoic Acids); EC 2.7.4.8 (Guanylate Kinases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.3945/jn.117.254607



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