Base de dados : MEDLINE
Pesquisa : C18.654.521.500.133.699.308 [Categoria DeCS]
Referências encontradas : 4321 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 433 ir para página                         

  1 / 4321 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29390264
[Au] Autor:Tan J; Li X; Guo Y; Xie L; Wang J; Ma J; Jiang L
[Ad] Endereço:Department of Neurology, Children's Hospital of Chongqing Medical University, Chongqing, China.
[Ti] Título:Hereditary folate malabsorption with a novel mutation on SLC46A1: A case report.
[So] Source:Medicine (Baltimore);96(50):e8712, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Hereditary folate malabsorption (HFM) is characterized by folate deficiency with impaired intestinal folate absorption and impaired folate transport into the central nervous system. Its manifestations mainly include macrocytic anemia, recurrent infections, and neurological deficits. The neurological manifestations include progressive psychomotor retardation, behavioral disorders, and early-onset seizures. PATIENT CONCERNS: From early infancy, a Chinese boy had experienced macrocytic anemia, leukopenia, thrombocytopenia, recurrent pneumonia, diarrhea, and mouth ulcers. He also presented with progressive neurological symptoms. DIAGNOSIS: A novel mutation in the SLC46A1 gene was identified, and HFM was diagnosed at 18 months of age. INTERVENTIONS: After the HFM diagnosis, the boy was treated with folinic acid. LESSONS: Folinic acid supplementation is effective and may offer life-changing therapy for patients with HFM.
[Mh] Termos MeSH primário: Deficiência de Ácido Fólico/genética
Síndromes de Malabsorção/genética
Mutação
Transportador de Folato Acoplado a Próton/genética
[Mh] Termos MeSH secundário: Grupo com Ancestrais do Continente Asiático
China
Deficiência de Ácido Fólico/tratamento farmacológico
Seres Humanos
Lactente
Leucovorina/uso terapêutico
Síndromes de Malabsorção/tratamento farmacológico
Masculino
Complexo Vitamínico B/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proton-Coupled Folate Transporter); 0 (SLC46A1 protein, human); 12001-76-2 (Vitamin B Complex); Q573I9DVLP (Leucovorin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008712


  2 / 4321 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28460180
[Au] Autor:Sid V; Siow YL; O K
[Ad] Endereço:a St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB R2H 2A6, Canada.
[Ti] Título:Role of folate in nonalcoholic fatty liver disease.
[So] Source:Can J Physiol Pharmacol;95(10):1141-1148, 2017 Oct.
[Is] ISSN:1205-7541
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:Nonalcoholic fatty liver disease (NAFLD) is a spectrum of chronic liver conditions that are characterized by steatosis, inflammation, fibrosis, and liver injury. The global prevalence of NAFLD is rapidly increasing in proportion to the rising incidence of obesity and type 2 diabetes. Because NAFLD is a multifaceted disorder with many underlying metabolic abnormalities, currently, there is no pharmacological agent that is therapeutically approved for the treatment of this disease. Folate is a water-soluble B vitamin that plays an essential role in one-carbon transfer reactions involved in nucleic acid biosynthesis, methylation reactions, and sulfur-containing amino acid metabolism. The liver is the primary organ responsible for storage and metabolism of folates. Low serum folate levels have been observed in patients with obesity and diabetes. It has been reported that a low level of endogenous folates in rodents perturbs folate-dependent one-carbon metabolism, and may be associated with development of metabolic diseases such as NAFLD. This review highlights the biological role of folate in the progression of NAFLD and its associated metabolic complications including obesity and type 2 diabetes. Understanding the role of folate in metabolic disease may position this vitamin as a potential therapeutic for NAFLD.
[Mh] Termos MeSH primário: Deficiência de Ácido Fólico/metabolismo
Ácido Fólico/metabolismo
Fígado/metabolismo
Hepatopatia Gordurosa não Alcoólica/metabolismo
[Mh] Termos MeSH secundário: Animais
Metabolismo Energético
Ácido Fólico/uso terapêutico
Deficiência de Ácido Fólico/tratamento farmacológico
Deficiência de Ácido Fólico/patologia
Seres Humanos
Mediadores da Inflamação/metabolismo
Fígado/efeitos dos fármacos
Fígado/patologia
Hepatopatia Gordurosa não Alcoólica/tratamento farmacológico
Hepatopatia Gordurosa não Alcoólica/patologia
Estresse Oxidativo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Inflammation Mediators); 935E97BOY8 (Folic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1139/cjpp-2016-0681


  3 / 4321 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29176804
[Au] Autor:Tu HC; Lee GH; Hsiao TH; Kao TT; Wang TY; Tsai JN; Fu TF
[Ad] Endereço:The Institute of Basic Medical Sciences, National Cheng Kung University, College of Medicine, Tainan, Taiwan.
[Ti] Título:One crisis, diverse impacts-Tissue-specificity of folate deficiency-induced circulation defects in zebrafish larvae.
[So] Source:PLoS One;12(11):e0188585, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Folate (vitamin B9) is an essential nutrient required for cell survival, proliferation, differentiation and therefore embryogenesis. Folate deficiency has been associated with many diseases, including congenital heart diseases and megaloblastic anemia, yet the mechanisms underlying these remains elusive. Here, we examine the impact of folate deficiency on the development of the circulation system using a zebrafish transgenic line which displays inducible folate deficiency. Impaired hematopoiesis includes decreased hemoglobin levels, decreased erythrocyte number, increased erythrocyte size and aberrant c-myb expression pattern were observed in folate deficient embryos. Cardiac defects, including smaller chamber size, aberrant cardiac function and cmlc2 expression pattern, were also apparent in folate deficient embryos. Characterization of intracellular folate content in folate deficiency revealed a differential fluctuation among the different folate derivatives that carry a single carbon group at different oxidation levels. Rescue attempts by folic acid and nucleotides resulted in differential responses among affected tissues, suggesting that different pathomechanisms are involved in folate deficiency-induced anomalies in a tissue-specific manner. The results of the current study provide an explanation for the inconsistent outcome observed clinically in patients suffering from folate deficiency and/or receiving folate supplementation. This study also supports the use of this model for further research on the defective cardiogenesis and hematopoiesis caused by folate deficiency.
[Mh] Termos MeSH primário: Circulação Sanguínea
Deficiência de Ácido Fólico/fisiopatologia
Larva/metabolismo
Peixe-Zebra/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
Animais Geneticamente Modificados
Movimento Celular
Proliferação Celular
Desenvolvimento Embrionário
Coração/embriologia
Hematopoese
Peixe-Zebra/embriologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188585


  4 / 4321 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28766851
[Au] Autor:Roy Moulik N; Kumar A; Agrawal S; Mahdi AA
[Ad] Endereço:Department of Paediatrics, Royal Marsden Hospital, Sutton, Greater London, United Kingdom.
[Ti] Título:Folate deficiency in north Indian children undergoing maintenance chemotherapy for acute lymphoblastic leukemia-Implications and outcome.
[So] Source:Pediatr Blood Cancer;65(1), 2018 Jan.
[Is] ISSN:1545-5017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Treatment-related toxicity and mortality are not uncommon during maintenance chemotherapy for childhood acute lymphoblastic leukemia (ALL), especially in the low- and middle-income countries (LMIC). Undernutrition and micronutrient deficiencies are commonly seen in children from LMICs undergoing treatment for ALL. The present study examines the prevalence and clinical implications of folate deficiency in north Indian children with ALL during the maintenance phase of treatment in view of prolonged antifolate treatment and high population prevalence of folate deficiency. PROCEDURES: Pre-cycle folate levels/deficiency as well as weight for age z-score and serum albumin level were determined and correlated with complications of treatment and mortality encountered during the maintenance phase of treatment. RESULTS: Twenty-nine of 52 children enrolled in the study had folate deficiency at some point during maintenance chemotherapy. Neutropenia (18 of 29 vs. 4 of 23; P = 0.002), thrombocytopenia (17 of 29 vs. 4 of 23; P = 0.005), febrile neutropenia (17 of 29 vs. 4 of 23; P = 0.005), and need for chemotherapy dose reduction (20 of 29 vs. 7 of 21; P = 0.01) were more common in folate-deficient children. Maintenance deaths were higher (8 of 29 vs. 1 of 23; P = 0.03) and survival lower (P = 0.02) in deficient children. In multivariate analysis, hypoalbuminemia (P = 0.02) and folate deficiency (P = 0.01) were associated with febrile neutropenia, and folate deficiency with maintenance deaths (P = 0.03). CONCLUSIONS: Folate deficiency was associated with treatment-related complications and adverse outcome in our patients. The risks and benefits of folate supplementation in deficient children during maintenance chemotherapy need to be explored with properly designed randomized studies in similar settings.
[Mh] Termos MeSH primário: Deficiência de Ácido Fólico/mortalidade
Quimioterapia de Manutenção
Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico
Leucemia-Linfoma Linfoblástico de Células Precursoras/mortalidade
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Intervalo Livre de Doença
Neutropenia Febril/sangue
Neutropenia Febril/tratamento farmacológico
Neutropenia Febril/mortalidade
Feminino
Deficiência de Ácido Fólico/sangue
Seres Humanos
Índia/epidemiologia
Masculino
Leucemia-Linfoma Linfoblástico de Células Precursoras/sangue
Prevalência
Taxa de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171201
[Lr] Data última revisão:
171201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1002/pbc.26730


  5 / 4321 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28471487
[Au] Autor:Hwang SY; Kang YJ; Sung B; Jang JY; Hwang NL; Oh HJ; Ahn YR; Kim HJ; Shin JH; Yoo MA; Kim CM; Chung HY; Kim ND
[Ad] Endereço:Department of Pharmacy, College of Pharmacy, Pusan National University, Busan, Republic of Korea.
[Ti] Título:Folic acid is necessary for proliferation and differentiation of C2C12 myoblasts.
[So] Source:J Cell Physiol;233(2):736-747, 2018 Feb.
[Is] ISSN:1097-4652
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Folic acid, a water soluble B vitamin, plays an important role in cellular metabolic activities, such as functioning as a cofactor in one-carbon metabolism for DNA and RNA synthesis as well as nucleotide and amino acid biosynthesis in the body. A lack of dietary folic acid can lead to folic acid deficiency and result in several health problems, including macrocytic anemia, elevated plasma homocysteine, cardiovascular disease, birth defects, carcinogenesis, muscle weakness, and walking difficulty. However, the effect of folic acid deficiency on skeletal muscle development and its molecular mechanisms are unknown. We, therefore, investigated the effect of folic acid deficiency on myogenesis in skeletal muscle cells and found that folic acid deficiency induced proliferation inhibition and cell cycle breaking as well as cellular senescence in C2C12 myoblasts, implying that folic acid deficiency influences skeletal muscle development. Folic acid deficiency also inhibited differentiation of C2C12 myoblasts and induced deregulation of the cell cycle exit and many cell cycle regulatory genes. It inhibited expression of muscle-specific marker MyHC as well as myogenic regulatory factor (myogenin). Moreover, immunocytochemistry and Western blot analyses revealed that DNA damage was more increased in folic acid-deficient medium-treated differentiating C2C12 cells. Furthermore, we found that folic acid resupplementation reverses the effect on the cell cycle and senescence in folic acid-deficient C2C12 myoblasts but does not reverse the differentiation of C2C12 cells. Altogether, the study results suggest that folic acid is necessary for normal development of skeletal muscle cells.
[Mh] Termos MeSH primário: Diferenciação Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Deficiência de Ácido Fólico/tratamento farmacológico
Ácido Fólico/farmacologia
Desenvolvimento Muscular/efeitos dos fármacos
Mioblastos Esqueléticos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Ciclo Celular/efeitos dos fármacos
Linhagem Celular
Senescência Celular/efeitos dos fármacos
Dano ao DNA
Deficiência de Ácido Fólico/metabolismo
Deficiência de Ácido Fólico/patologia
Camundongos
Mioblastos Esqueléticos/metabolismo
Mioblastos Esqueléticos/patologia
Miogenina/metabolismo
Cadeias Pesadas de Miosina/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Myog protein, mouse); 0 (Myogenin); 935E97BOY8 (Folic Acid); EC 3.6.4.1 (Myosin Heavy Chains)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1002/jcp.25989


  6 / 4321 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29049201
[Au] Autor:Fan C; Yu S; Zhang S; Ding X; Su J; Cheng Z
[Ad] Endereço:Department of Oral and Maxillofacial Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
[Ti] Título:Association between folate intake and risk of head and neck squamous cell carcinoma: An overall and dose-response PRISMA meta-analysis.
[So] Source:Medicine (Baltimore);96(42):e8182, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The results of published studies about the relationships between folate intake and risk of head and neck squamous cell carcinoma (HNSCC) remained inconsistent. Hence, a comprehensive and dose-response meta-analysis was performed to clarify the association between folate intake and HNSCC risk.The electric searches of Pubmed, Medline, and EMBASE databases were performed to identify the studies examining the relationship between folate intake and HNSCC risk on April 5, 2017. According to the inclusion criteria, finally 9 studies were included in this meta-analysis. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of associations. Dose-response analysis was conducted to quantitate the relationship between dietary folate intake and HNSCC risk.The pooled OR for assessing the risk of HNSCC and folate intake in the highest level versus lowest level was 0.505 (95% CI 0.387-0.623). The linearity model of dose-response analysis indicated that with increased 100 µg/d folate intake, the risk of HNSCC decreased 4.3% degree (OR 0.957, 95% CI 0.935-0.980).These results indicate that folate is a protective nutrient against HNSCC carcinogenesis.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/etiologia
Dieta/efeitos adversos
Ingestão de Alimentos
Deficiência de Ácido Fólico/complicações
Ácido Fólico/análise
Neoplasias de Cabeça e Pescoço/etiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Dieta/métodos
Relação Dose-Resposta a Droga
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Observacionais como Assunto
Razão de Chances
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
935E97BOY8 (Folic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008182


  7 / 4321 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28797054
[Au] Autor:Noor RA; Abioye AI; Ulenga N; Msham S; Kaishozi G; Gunaratna NS; Mwiru R; Smith E; Dhillon CN; Spiegelman D; Fawzi W
[Ad] Endereço:Africa Academy for Public Health (AAPH), Dar es Salaam, Tanzania.
[Ti] Título:Large -scale wheat flour folic acid fortification program increases plasma folate levels among women of reproductive age in urban Tanzania.
[So] Source:PLoS One;12(8):e0182099, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There is widespread vitamin and mineral deficiency problem in Tanzania with known deficiencies of at least vitamin A, iron, folate and zinc, resulting in lasting negative consequences especially on maternal health, cognitive development and thus the nation's economic potential. Folate deficiency is associated with significant adverse health effects among women of reproductive age, including a higher risk of neural tube defects. Several countries, including Tanzania, have implemented mandatory fortification of wheat and maize flour but evidence on the effectiveness of these programs in developing countries remains limited. We evaluated the effectiveness of Tanzania's food fortification program by examining folate levels for women of reproductive age, 18-49 years. A prospective cohort study with 600 non-pregnant women enrolled concurrent with the initiation of food fortification and followed up for 1 year thereafter. Blood samples, dietary intake and fortified foods consumption data were collected at baseline, and at 6 and 12 months. Plasma folate levels were determined using a competitive assay with folate binding protein. Using univariate and multivariate linear regression, we compared the change in plasma folate levels at six and twelve months of the program from baseline. We also assessed the relative risk of folate deficiency during follow-up using log-binomial regression. The mean (±SE) pre-fortification plasma folate level for the women was 5.44-ng/ml (±2.30) at baseline. These levels improved significantly at six months [difference: 4.57ng/ml (±2.89)] and 12 months [difference: 4.27ng/ml (±4.18)]. Based on plasma folate cut-off level of 4 ng/ml, the prevalence of folate deficiency was 26.9% at baseline, and 5% at twelve months. One ng/ml increase in plasma folate from baseline was associated with a 25% decreased risk of folate deficiency at 12 months [(RR = 0.75; 95% CI = 0.67-0.85, P<0.001]. In a setting where folate deficiency is high, food fortification program with folic acid resulted in significant improvements in folate status among women of reproductive age.
[Mh] Termos MeSH primário: Farinha
Deficiência de Ácido Fólico/sangue
Ácido Fólico/administração & dosagem
Ácido Fólico/sangue
Alimentos Fortificados
Defeitos do Tubo Neural/prevenção & controle
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Meia-Idade
Tanzânia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
935E97BOY8 (Folic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182099


  8 / 4321 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28446502
[Au] Autor:Bailey RL; Fulgoni VL; Taylor CL; Pfeiffer CM; Thuppal SV; McCabe GP; Yetley EA
[Ad] Endereço:Departments of Nutrition Science and regan.bailey@gmail.com.
[Ti] Título:Correspondence of folate dietary intake and biomarker data.
[So] Source:Am J Clin Nutr;105(6):1336-1343, 2017 Jun.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Public health concerns with regard to both low and high folate status exist in the United States. Recent publications have questioned the utility of self-reported dietary intake data in research and monitoring. The purpose of this analysis was to examine the relation between self-reported folate intakes and folate status biomarkers and to evaluate their usefulness for several types of applications. We examined usual dietary intakes of folate by using the National Cancer Institute method to adjust two 24-h dietary recalls (including dietary supplements) for within-person variation and then compared these intakes with serum and red blood cell (RBC) folate among 4878 men and nonpregnant, nonlactating women aged ≥19 y in NHANES 2011-2012, a nationally representative, cross-sectional survey, with respect to consistency across prevalence estimates and rank order comparisons. There was a very low prevalence (<1%) of folate deficiency when serum (<7 nmol/L) and RBC (<305 nmol/L) folate were considered, whereas a higher proportion of the population reported inadequate total dietary folate intakes (6%). Similar patterns of change occurred between intakes and biomarkers of folate status when distributions were examined (i.e., dose response), particularly when diet was expressed in µg. Intakes greater than the Tolerable Upper Intake Level greatly increased the odds of having high serum folate (OR: 17.6; 95% CI: 5.5, 56.0). When assessing folate status in the United States, where fortification and supplement use are common, similar patterns in the distributions of diet and biomarkers suggest that these 2 types of status indicators reflect the same underlying folate status; however, the higher prevalence estimates for inadequate intakes compared with biomarkers suggest, among other factors, a systematic underestimation bias in intake data. Caution is needed in the use of dietary folate data to estimate the prevalence of inadequacy among population groups. The use of dietary data for rank order comparisons or to estimate the potential for dietary excess is likely more reliable.
[Mh] Termos MeSH primário: Ingestão de Energia
Comportamento Alimentar
Deficiência de Ácido Fólico/sangue
Ácido Fólico/sangue
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores/sangue
Estudos Transversais
Dieta
Suplementos Nutricionais
Eritrócitos/metabolismo
Feminino
Ácido Fólico/administração & dosagem
Deficiência de Ácido Fólico/epidemiologia
Seres Humanos
Masculino
Rememoração Mental
Meia-Idade
Inquéritos Nutricionais
Prevalência
Autorrelato
Estados Unidos/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 935E97BOY8 (Folic Acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.148775


  9 / 4321 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:28407838
[Au] Autor:Wu MM; Yang F; Qu Y; Mu DZ
[Ad] Endereço:Department of Pediatrics, West China Second University Hospital, Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu 610041, China. 506742295@qq.com.
[Ti] Título:[Effects of maternal folate deficiency on the methylation of insulin-like growth factor system in the offspring rats].
[So] Source:Zhongguo Dang Dai Er Ke Za Zhi;19(4):470-474, 2017 Apr.
[Is] ISSN:1008-8830
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To study the effects of maternal folate deficiency on fetal growth and development and the methylation profiles of insulin-like growth factor system in the offspring rats. METHODS: Twenty-two Sprague-Dawley female rats were randomly assigned to two groups: a folate deficient group (n=12) and a control group (n=10). They were fed with folate deficient and normal diet respectively. Dams were mated after 2 weeks of feeding. Eight female rats from each group were pregnant. On the 20th day of gestation, the fetuses were delivered by caesarean section. Thirty-two fetal rats from each group were randomly selected and the body length and weight were measured. Eight fetal rats from each group were randomly selected and ELISA was used to measure the level of folate content, IGF-1 and IGFBP-3 in the fetal brain and liver. Three fetal rats from each group were randomly selected and methylated DNA immunoprecipitation sequencing (MeDIP-Seq) was used to detect the methylation level of insulin-like growth factor system in the fetal brain and liver. ELISA was used to measure the level of IGF-1 and IGFBP-3 in the maternal serum from both groups. RESULTS: The mean fetal length and weight were lower in the folate deficient group than in the control group (P<0.05). The levels of IGF-1 and IGFBP-3 in the maternal serum, as well as folate content and IGFBP-3 in the fetal brain and liver were significantly lower in the folate deficient group than in the control group (P<0.05). The methylation levels of IGF-1R, IGF-2R, IGFBP-2, IGFBP-5, IGFBP-6 and IGFBP-7 in the fetal brain were higher in the folate deficient group than in the control group (P<0.05). The methylation levels of IGF-1R, IGF-2R, IGFBP-3 and IGFBP-5 in the fetal liver were higher in the folate deficient group than in the control group. The methylation of IGF-2 gene showed a significant reduction in the folate deficient group (P<0.05). CONCLUSIONS: Maternal folate deficiency may cause retardation of growth and development of the offspring, which is possibly associated with the changes of methylation profiles of insulin-like growth factors.
[Mh] Termos MeSH primário: Metilação de DNA
Feto/metabolismo
Deficiência de Ácido Fólico/metabolismo
Proteína 3 de Ligação a Fator de Crescimento Semelhante à Insulina/sangue
Fator de Crescimento Insulin-Like I/análise
[Mh] Termos MeSH secundário: Animais
Encéfalo/metabolismo
Feminino
Desenvolvimento Fetal
Fígado/metabolismo
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insulin-Like Growth Factor Binding Protein 3); 67763-96-6 (Insulin-Like Growth Factor I)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170801
[Lr] Data última revisão:
170801
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE


  10 / 4321 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28406440
[Au] Autor:Pan Y; Liu Y; Guo H; Jabir MS; Liu X; Cui W; Li D
[Ad] Endereço:Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, 1163 Xinmin Avenue, Changchun 130021, China. yunpan14@mails.jlu.edu.cn.
[Ti] Título:Associations between Folate and Vitamin B12 Levels and Inflammatory Bowel Disease: A Meta-Analysis.
[So] Source:Nutrients;9(4), 2017 04 13.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Inflammatory bowel disease (IBD) patients may be at risk of vitamin B12 and folate insufficiencies, as these micronutrients are absorbed in the small intestine, which is affected by IBD. However, a consensus has not been reached on the association between IBD and serum folate and vitamin B12 concentrations. METHODS: In this study, a comprehensive search of multiple databases was performed to identify studies focused on the association between IBD and serum folate and vitamin B12 concentrations. Studies that compared serum folate and vitamin B12 concentrations between IBD and control patients were selected for inclusion in the meta-analysis. RESULTS: The main outcome was the mean difference in serum folate and vitamin B12 concentrations between IBD and control patients. Our findings indicated that the average serum folate concentration in IBD patients was significantly lower than that in control patients, whereas the mean serum vitamin B12 concentration did not differ between IBD patients and controls. In addition, the average serum folate concentration in patients with ulcerative colitis (UC) but not Crohn's disease (CD) was significantly lower than that in controls. This meta-analysis identified a significant relationship between low serum folate concentration and IBD. CONCLUSIONS: Our findings suggest IBD may be linked with folate deficiency, although the results do not indicate causation. Thus, providing supplements of folate and vitamin B12 to IBD patients may improve their nutritional status and prevent other diseases.
[Mh] Termos MeSH primário: Deficiência de Ácido Fólico/etiologia
Ácido Fólico/sangue
Doenças Inflamatórias Intestinais/fisiopatologia
Estado Nutricional
Deficiência de Vitamina B 12/etiologia
Vitamina B 12/sangue
[Mh] Termos MeSH secundário: Colite Ulcerativa/sangue
Colite Ulcerativa/imunologia
Colite Ulcerativa/metabolismo
Colite Ulcerativa/fisiopatologia
Doença de Crohn/sangue
Doença de Crohn/imunologia
Doença de Crohn/metabolismo
Doença de Crohn/fisiopatologia
Suplementos Nutricionais
Ácido Fólico/metabolismo
Ácido Fólico/uso terapêutico
Deficiência de Ácido Fólico/dietoterapia
Deficiência de Ácido Fólico/prevenção & controle
Seres Humanos
Doenças Inflamatórias Intestinais/sangue
Doenças Inflamatórias Intestinais/imunologia
Doenças Inflamatórias Intestinais/metabolismo
Absorção Intestinal
Mucosa Intestinal/imunologia
Mucosa Intestinal/metabolismo
Vitamina B 12/metabolismo
Vitamina B 12/uso terapêutico
Deficiência de Vitamina B 12/dietoterapia
Deficiência de Vitamina B 12/prevenção & controle
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
935E97BOY8 (Folic Acid); P6YC3EG204 (Vitamin B 12)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE



página 1 de 433 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde