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  1 / 12528 MEDLINE  
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[PMID]:29505508
[Au] Autor:Li W; Cheng X; Guo L; Li H; Sun C; Cui X; Zhang Q; Song G
[Ad] Endereço:Department of ICU, Affiliated Children's Hospital of Capital Institute of Pediatrics.
[Ti] Título:Association between serum 25-hydroxyvitamin D concentration and pulmonary infection in children.
[So] Source:Medicine (Baltimore);97(1):e9060, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We assessed the relationship between serum 25-hydroxyvitamin D (25(OH)D) level and community-acquired pneumonia (CAP) among Chinese children.This observational study examined children aged 3 days to 14 years (n = 1582) from the Capital Institute of Pediatrics in 2009 to 2011. There were 797 children in the CAP group and 785 controls. The CAP group was divided into 2 groups: a pneumonia group and pneumonia-induced sepsis group. The serum 25(OH)D level was estimated using micro whole blood chemiluminescence.The average serum 25(OH)D level in all samples was 25.32 ±â€Š14.07 ng/mL, with the CAP group showing a lower value than the control group (P < .001). There were also significant differences between the pneumonia group and pneumonia-induced sepsis group (P < .001). In the pneumonia-induced sepsis group, significant differences in serum 25(OH)D levels were observed in children who received mechanical ventilation or presenting with multiple organ dysfunction (P < .01).All serum 25(OH)D levels in the pneumonia group and pneumonia-induced sepsis group were below normal levels, particularly in the sepsis group. A lower serum 25(OH)D level was associated with more serious symptoms in CAP children. Children with low serum 25(OH)D levels may be at higher risk of receiving mechanical ventilation and presenting with multiple organ dysfunction. These findings suggest that vitamin D supplements are beneficial for the treatment and prevention of CAP.
[Mh] Termos MeSH primário: Pneumonia/sangue
Deficiência de Vitamina D/complicações
Vitamina D/análogos & derivados
[Mh] Termos MeSH secundário: Adolescente
Estudos de Casos e Controles
Criança
Pré-Escolar
Infecções Comunitárias Adquiridas/sangue
Infecções Comunitárias Adquiridas/etiologia
Feminino
Seres Humanos
Lactente
Recém-Nascido
Masculino
Estado Nutricional
Pneumonia/etiologia
Curva ROC
Estações do Ano
Sepse/sangue
Sepse/etiologia
Vitamina D/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
1406-16-2 (Vitamin D); 64719-49-9 (25-hydroxyvitamin D)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180306
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009060


  2 / 12528 MEDLINE  
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[PMID]:29216203
[Au] Autor:Raed A; Bhagatwala J; Zhu H; Pollock NK; Parikh SJ; Huang Y; Havens R; Kotak I; Guo DH; Dong Y
[Ad] Endereço:Georgia Prevention Institute, Department of Population Health Sciences, Medical College of Georgia, Augusta University, Augusta, Georgia, United States of America.
[Ti] Título:Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial.
[So] Source:PLoS One;12(12):e0188424, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Clinical trials are scant and equivocal on whether vitamin D can ameliorate arterial stiffness, particularly in populations at high risk for vitamin D deficiency and cardiovascular disease (CVD). This study determined the dose-response effects of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency. METHODS: Seventy overweight African Americans (aged 13-45 years) with serum 25-hydroxyvitamin D [25(OH)D] levels ≤ 20 ng/mL were randomized to monthly oral supplementation of 18,000 IU (~600 IU/day, n = 17), 60,000 IU (~2000 IU/day, n = 18), or 120,000 IU (~4000 IU/day, n = 18) of vitamin D3 or placebo (n = 17) for 16-weeks. The arterial stiffness measurements, carotid-femoral pulse wave velocity (PWV) and carotid-radial PWV, were assessed by applanation tonometry at baseline and 16 weeks. RESULTS: Vitamin D3 supplementation demonstrated a dose-response increase in serum 25(OH)D concentrations between groups (P<0.01). A significant downward linear trend was observed for carotid-femoral PWV (P<0.01), as the mean changes in carotid-femoral PWV across the four treatment groups were 0.13 m/s (95% CI: -0.24, 0.51 m/s) for placebo, 0.02 m/s (95% CI: -0.34, 0.38 m/s) for 600 IU/day group, -0.11 m/s (95% CI: -0.50, 0.27 m/s) for the 2,000 IU/day group, and -0.70 m/s (95% CI: -1.07, -0.32 m/s) for the 4,000 IU/day group. Findings were similar for carotid-radial PWV (P = 0.03), as the mean changes in carotid-radial PWV across the four treatment groups were 0.24 m/s (95% CI: -0.45, 0.92 m/s) for placebo, 0.09 m/s (95% CI: -0.54, 0.73 m/s) for 600 IU/day group, -0.57 m/s (95% CI: -1.20, 0.07 m/s) for the 2,000 IU/day group, and -0.61 m/s (95% CI: -1.25, 0.02 m/s) for the 4,000 IU/day group. CONCLUSION: Arterial stiffness was improved by vitamin D3 supplementation in a dose-response manner in overweight African Americans with vitamin D deficiency.
[Mh] Termos MeSH primário: Afroamericanos
Artérias/fisiopatologia
Colecalciferol/administração & dosagem
Obesidade/complicações
Rigidez Vascular/efeitos dos fármacos
Deficiência de Vitamina D/tratamento farmacológico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Colecalciferol/farmacologia
Relação Dose-Resposta a Droga
Método Duplo-Cego
Feminino
Seres Humanos
Masculino
Placebos
Deficiência de Vitamina D/complicações
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Placebos); 1C6V77QF41 (Cholecalciferol)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188424


  3 / 12528 MEDLINE  
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[PMID]:28451877
[Au] Autor:Grübler MR; März W; Pilz S; Grammer TB; Trummer C; Müllner C; Schwetz V; Pandis M; Verheyen N; Tomaschitz A; Fiordelisi A; Laudisio D; Cipolletta E; Iaccarino G
[Ad] Endereço:Swiss Cardiovascular Centre Bern, Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 8, 3010, Bern, Switzerland. martin.gruebler@gmx.net.
[Ti] Título:Vitamin-D concentrations, cardiovascular risk and events - a review of epidemiological evidence.
[So] Source:Rev Endocr Metab Disord;18(2):259-272, 2017 Jun.
[Is] ISSN:1573-2606
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Vitamin D has long been established as an elemental factor of bone physiology. Beyond mineral metabolism, the expression of the vitamin D receptor has been identified throughout the cardiovascular (CV) system. Experimental studies showed beneficial effects of vitamin D on heart and vessels, but vitamin D intoxication in animals also led to hypercalcemia and vascular calcification. Our knowledge has been extended by epidemiological studies that showed that 25-hydroxyvitamin D (25(OH)D) levels are inversely associated with an increased CV risk itself, but also with established CV risk factors, such as arterial hypertension, endothelial dysfunction and atherosclerosis. Conversely, randomized controlled trials could not document significant and consistent effects of vitamin D supplementation on CV risk or events. Potential explanations may lie in differences in reference ranges or the possibility that low vitamin D in CV disease is only an epiphenomenon. In the latter case, the key question is why low 25(OH)D levels are such a strong predictor of health. While we wait for new data, the current conclusion is that vitamin D is a strong risk marker for CV risk factors and for CV diseases itself.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/epidemiologia
Doenças Cardiovasculares/etiologia
Deficiência de Vitamina D/epidemiologia
Vitamina D/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Doenças Cardiovasculares/sangue
Sistema Cardiovascular/efeitos dos fármacos
Sistema Cardiovascular/metabolismo
Seres Humanos
Fatores de Risco
Vitamina D/sangue
Vitamina D/farmacologia
Deficiência de Vitamina D/sangue
Deficiência de Vitamina D/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
1406-16-2 (Vitamin D); 64719-49-9 (25-hydroxyvitamin D)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1007/s11154-017-9417-0


  4 / 12528 MEDLINE  
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[PMID]:29202486
[Au] Autor:Polasik K; Piotrowska E; Lipinska B; Witkowski JM; Bryl E; Tukaj S
[Ad] Endereço:Department of Molecular Biology, Faculty of Biology, University of Gdansk, Gdansk, Poland.
[Ti] Título:Vitamin D status in patients with rheumatoid arthritis: a correlation analysis with disease activity and progression, as well as serum IL-6 levels.
[So] Source:Acta Biochim Pol;64(4):667-670, 2017.
[Is] ISSN:1734-154X
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Recent epidemiological studies suggested an association between a poor vitamin D [25(OH)D] status, inflammatory mediators, and rheumatoid arthritis (RA). We have recently proposed that pro-inflammatory interleukin 6 (IL-6) may represent a good marker for disease activity of RA. The aim of this study was to investigate the relationship between serum 25(OH)D levels and disease activity, joint damage, as well as serum IL-6 levels in a Polish RA population. MATERIALS AND METHODS: Serum 25(OH)D levels were measured in 35 female RA patients and 38 age- and gender-matched healthy controls. Statistical correlations between 25(OH)D levels and the disease activity score 28 (DAS 28), joint damage based on the Steinbrocker criteria, as well as serum IL-6 levels were performed. RESULTS: There was no statistically significant difference between levels of 25(OH)D in RA (16.89±8.57 ng/ml) and healthy controls (14.12±7.51 ng/ml), and the vitamin D deficiency (<20 ng/ml) was found in 71.43% of RA patients and 73.68 % of healthy controls. While vitamin D status did not correlate with DAS 28 (r=0.265, p=0.149) and joint damage based on the Steinbrocker criteria (r=0.367, p=0.065), a positive correlation between 25(OH)D and IL-6 (r=0.537, p=0.002) was observed in RA. CONCLUSION: Although further studies on a larger group of patients will be needed to confirm the data presented here, it seems that hypovitaminosis D is common in the RA patients and middle-aged non-RA healthy women in the Polish population. 25(OH)D levels were similar in the RA patients and age- and gender-matched healthy controls, and were not associated with joint damage and disease activity in patients.
[Mh] Termos MeSH primário: Artrite Reumatoide/etiologia
Interleucina-6/sangue
Vitamina D/sangue
[Mh] Termos MeSH secundário: Adulto
Artrite Reumatoide/sangue
Estudos de Casos e Controles
Feminino
Seres Humanos
Meia-Idade
Deficiência de Vitamina D/sangue
Deficiência de Vitamina D/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (IL6 protein, human); 0 (Interleukin-6); 1406-16-2 (Vitamin D)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.18388/abp.2017_1636


  5 / 12528 MEDLINE  
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[PMID]:29177267
[Au] Autor:Mazokopakis E; Papadomanolaki M; Skarakis SN; Tsekouras K
[Ad] Endereço:Department of Internal Medicine, Naval Hospital of Crete, Souda 73 200, Chania, Crete, Greece. emazokopakis@yahoo.gr.
[Ti] Título:Primary and secondary hyperparathyroidism among vitamin D deficient Hashimoto's thyroiditis patients and the need for a parathyroid scan.
[So] Source:Hell J Nucl Med;20(3):258-259, 2017 Sep-Dec.
[Is] ISSN:1790-5427
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:The patients with Hashimoto thyroiditis must be investigated mainly for secondary hyperparathyroidism due to vitamin D deficiency/insufficiency. Parathyroid scintigraphy has no place in the diagnosis of primary, secondary or tertiary hyperparathyroidism or in the decision for surgical treatment. Parathyroid scintigraphy is a useful preoperative technique for the localization of the pathological parathyroid glands.
[Mh] Termos MeSH primário: Doença de Hashimoto/sangue
Doença de Hashimoto/diagnóstico por imagem
Hiperparatireoidismo/sangue
Hiperparatireoidismo/diagnóstico por imagem
Cintilografia/métodos
Deficiência de Vitamina D/sangue
Vitamina D/sangue
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/sangue
Diagnóstico Diferencial
Feminino
Seres Humanos
Masculino
Glândulas Paratireoides/diagnóstico por imagem
Hormônio Paratireóideo/sangue
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Deficiência de Vitamina D/diagnóstico por imagem
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Biomarkers); 0 (Parathyroid Hormone); 1406-16-2 (Vitamin D)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1967/s002449910613


  6 / 12528 MEDLINE  
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[PMID]:29370213
[Au] Autor:Borg SA; Buckley H; Owen R; Marin AC; Lu Y; Eyles D; Lacroix D; Reilly GC; Skerry TM; Bishop NJ
[Ad] Endereço:Academic Unit of Child Health Department of Oncology & Metabolism, University of Sheffield, Sheffield, United Kingdom.
[Ti] Título:Early life vitamin D depletion alters the postnatal response to skeletal loading in growing and mature bone.
[So] Source:PLoS One;13(1):e0190675, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There is increasing evidence of persistent effects of early life vitamin D exposure on later skeletal health; linking low levels in early life to smaller bone size in childhood as well as increased fracture risk later in adulthood, independently of later vitamin D status. A major determinant of bone mass acquisition across all ages is mechanical loading. We tested the hypothesis in an animal model system that early life vitamin D depletion results in abrogation of the response to mechanical loading, with consequent reduction in bone size, mass and strength during both childhood and adulthood. A murine model was created in which pregnant dams were either vitamin D deficient or replete, and their offspring moved to a vitamin D replete diet at weaning. Tibias of the offspring were mechanically loaded and bone structure, extrinsic strength and growth measured both during growth and after skeletal maturity. Offspring of vitamin D deplete mice demonstrated lower bone mass in the non loaded limb and reduced bone mass accrual in response to loading in both the growing skeleton and after skeletal maturity. Early life vitamin D depletion led to reduced bone strength and altered bone biomechanical properties. These findings suggest early life vitamin D status may, in part, determine the propensity to osteoporosis and fracture that blights later life in many individuals.
[Mh] Termos MeSH primário: Desenvolvimento Ósseo
Osso e Ossos/fisiopatologia
Deficiência de Vitamina D/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Densidade Óssea
Feminino
Análise de Elementos Finitos
Seres Humanos
Camundongos
Camundongos Endogâmicos C57BL
Gravidez
Estresse Mecânico
Vitamina D/administração & dosagem
Microtomografia por Raio-X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
1406-16-2 (Vitamin D)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190675


  7 / 12528 MEDLINE  
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[PMID]:28740372
[Au] Autor:Vandenbroucke A; Luyten FP; Flamaing J; Gielen E
[Ad] Endereço:Clinical Department of Internal Medicine, UZ Leuven.
[Ti] Título:Pharmacological treatment of osteoporosis in the oldest old.
[So] Source:Clin Interv Aging;12:1065-1077, 2017.
[Is] ISSN:1178-1998
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:The incidence of osteoporotic fractures increases with age. Consequently, the global prevalence of osteoporotic fractures will increase with the aging of the population. In old age, osteoporosis is associated with a substantial burden in terms of morbidity and mortality. Nevertheless, osteoporosis in old age continues to be underdiagnosed and undertreated. This may, at least partly, be explained by the fact that evidence of the antifracture efficacy of osteoporosis treatments comes mainly from randomized controlled trials in postmenopausal women with a mean age of 70-75 years. However, in the last years, subgroup analyses of these landmark trials have been published investigating the efficacy and safety of osteoporosis treatment in the very elderly. Based on this evidence, this narrative review discusses the pharmacological management of osteoporosis in the oldest old (≥80 years). Because of the high prevalence of calcium and/or vitamin D deficiency in old age, these supplements are essential in the management of osteoporosis in the elderly people. Adding antiresorptive or anabolic treatments or combinations, thereof, reduces the risk of vertebral fractures even more, at least in the elderly with documented osteoporosis. The reduction of hip fracture risk by antiresorptive treatments is less convincing, which may be explained by insufficient statistical power in some subanalyses and/or a higher impact of nonskeletal risk factors in the occurrence of hip fractures. Compared with younger individuals, a larger absolute risk reduction is observed in the elderly because of the higher baseline fracture risk. Therefore, the elderly will benefit more of treatment. In addition, current osteoporosis therapies also appear to be safe in the elderly. Although more research is required to further clarify the effect of osteoporosis drugs in the elderly, especially with respect to hip fractures, there is currently sufficient evidence to initiate appropriate treatment in the elderly with osteoporosis and osteoporotic fractures.
[Mh] Termos MeSH primário: Conservadores da Densidade Óssea/uso terapêutico
Osteoporose/tratamento farmacológico
Osteoporose/epidemiologia
Fraturas por Osteoporose/prevenção & controle
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Conservadores da Densidade Óssea/administração & dosagem
Conservadores da Densidade Óssea/efeitos adversos
Cálcio/deficiência
Cálcio na Dieta
Suplementos Nutricionais
Difosfonatos/uso terapêutico
Feminino
Fraturas do Quadril/prevenção & controle
Seres Humanos
Osteoporose Pós-Menopausa/tratamento farmacológico
Fatores de Risco
Fraturas da Coluna Vertebral/prevenção & controle
Deficiência de Vitamina D/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Bone Density Conservation Agents); 0 (Calcium, Dietary); 0 (Diphosphonates); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.2147/CIA.S131023


  8 / 12528 MEDLINE  
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[PMID]:29345464
[Au] Autor:Saande CJ; Jones SK; Rowling MJ; Schalinske KL
[Ad] Endereço:Interdepartmental Graduate Program in Nutritional Sciences and Department of Food Science and Human Nutrition, Iowa State University , Ames, Iowa 50011, United States.
[Ti] Título:Whole Egg Consumption Exerts a Nephroprotective Effect in an Acute Rodent Model of Type 1 Diabetes.
[So] Source:J Agric Food Chem;66(4):866-870, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nephropathy is a well-characterized complication of type 1 diabetes (T1D), resulting in proteinuria and urinary loss of micronutrients. We previously found that a whole egg-based diet maintained vitamin D balance in type 2 diabetic rats despite excessive urinary losses due to nephropathy. The goal of this study was to investigate the impact of whole egg consumption in T1D rats. Sprague-Dawley rats were randomly assigned to T1D or nondiabetic control groups and fed a casein or whole egg-based diet for 32 days. On day 26, two-thirds of the rats received a streptozotocin injection to induce T1D. Whole egg consumption attenuated polyuria, proteinuria, and renal hypertrophy in T1D rats. These data suggest that dietary intervention with whole egg may offer renal protection in T1D.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/complicações
Diabetes Mellitus Tipo 1/complicações
Nefropatias Diabéticas/prevenção & controle
Dieta
Ovos
[Mh] Termos MeSH secundário: Animais
Hipertrofia/prevenção & controle
Rim/patologia
Masculino
Poliúria/prevenção & controle
Proteinúria/prevenção & controle
Ratos
Ratos Sprague-Dawley
Vitamina D/sangue
Deficiência de Vitamina D/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
1406-16-2 (Vitamin D)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04774


  9 / 12528 MEDLINE  
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[PMID]:28463872
[Au] Autor:Bragazzi NL; Watad A; Neumann SG; Simon M; Brown SB; Abu Much A; Harari A; Tiosano S; Amital H; Shoenfeld Y
[Ad] Endereço:aSchool of Public Health, Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy bDepartment of Medicine B cZabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer dSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
[Ti] Título:Vitamin D and rheumatoid arthritis: an ongoing mystery.
[So] Source:Curr Opin Rheumatol;29(4):378-388, 2017 Jul.
[Is] ISSN:1531-6963
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: In recent years, there has been a growing interest in the value of vitamin D and its effects on autoimmunity. The aim of this review is to summarize the current knowledge on the association between vitamin D and rheumatoid arthritis (RA) in terms of prevalence, disease activity, clinical expression, serology and gene polymorphisms of vitamin D receptors. RECENT FINDINGS: Studies have shown contrasting findings concerning the association between vitamin D levels and RA. Vitamin D seems to have immunomodulatory properties. Therefore, low vitamin D levels could contribute to increased immune activation. However, the potential role of vitamin D supplementation in preventing RA manifestation and its beneficial role as a component of RA treatment remain controversial. The relationship between RA susceptibility and vitamin D polymorphisms is also unclear. SUMMARY: Despite advancements synthesized by some recent meta-analyses, the relationship between vitamin D and RA requires further evaluation. Further research is needed to confirm the relationship between RA susceptibility and vitamin D polymorphisms and to determine whether vitamin D plays a role in preventing the manifestation of RA. Finally, additional studies are required to determine the impact and optimal amount of vitamin D supplementation in the treatment of RA patients.
[Mh] Termos MeSH primário: Artrite Reumatoide/epidemiologia
Deficiência de Vitamina D/epidemiologia
[Mh] Termos MeSH secundário: Artrite Reumatoide/tratamento farmacológico
Artrite Reumatoide/genética
Artrite Reumatoide/metabolismo
Progressão da Doença
Predisposição Genética para Doença
Seres Humanos
Polimorfismo Genético
Prevalência
Receptores de Calcitriol/genética
Fatores de Risco
Vitamina D/metabolismo
Vitamina D/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Receptors, Calcitriol); 1406-16-2 (Vitamin D)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1097/BOR.0000000000000397


  10 / 12528 MEDLINE  
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Fotocópia
[PMID]:29182823
[Au] Autor:Vranesic Bender D; Giljevic Z; Kusec V; Laktasic Zerjavic N; Bosnjak Pasic M; Vrdoljak E; Lkinas Kelecic Dina; Reiner Z; Anic B; Krznaric Z
[Ti] Título:GUIDELINES FOR THE PREVENTION, DETECTION AND THERAPY OF VITAMIN D DEFICIENCY IN ADULTS.
[So] Source:Lijec Vjesn;138(5-6):121-132, 2016 May.
[Is] ISSN:0024-3477
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:It is estimated that over one billion of people around the globe have low serum values of vitamin D, therefore, we can consider vitamin D deficiency as a pandemic and public health problem. Geographic position of Croatia, especially the continental part of the country, is a risk factor for the development of deficiency of vitamin D in the population. The aim of these guidelines is to provide the clinicians with easy and comprehensive tool for prevention, detection and therapy of vitamin D deficienney in healthy population and various groups of patients. They were made as a result of collaboration of clinicians of different backgrounds who are dealing with patients at risk of vitamin D deficiency. These guidelines are evi- dence-based, according to GRADE-system (Grading of Recommendations, Assessment, Development and Evaluation), which describes the level of evidence and strength of recommendation. The main conclusions address the recommended serum vitamin D values in the population which should be between 75 and 125 nmol/L and defining recommended preven- tive and therapeutic dosages of vitamin D in order to reach the adequate levels of serum vitamin D.
[Mh] Termos MeSH primário: Deficiência de Vitamina D
Vitamina D
[Mh] Termos MeSH secundário: Adulto
Croácia/epidemiologia
Prática Clínica Baseada em Evidências/métodos
Seres Humanos
Serviços Preventivos de Saúde/métodos
Serviços Preventivos de Saúde/organização & administração
Medição de Risco/métodos
Fatores de Risco
Vitamina D/sangue
Vitamina D/farmacologia
Deficiência de Vitamina D/sangue
Deficiência de Vitamina D/diagnóstico
Deficiência de Vitamina D/prevenção & controle
Deficiência de Vitamina D/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRACTICE GUIDELINE
[Nm] Nome de substância:
1406-16-2 (Vitamin D)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE



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