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[PMID]:28460640
[Au] Autor:Dam M; Neelemaat F; Struijk-Wielinga T; Weijs PJ; van Jaarsveld BC
[Ad] Endereço:VU University Medical Centre, department of Nutrition and Dietetics, Boelelaan 1117, 1081HV, Amsterdam, The Netherlands. m.dam2@vumc.nl.
[Ti] Título:Physical performance and protein-energy wasting in patients treated with nocturnal haemodialysis compared to conventional haemodialysis: protocol of the DiapriFIT study.
[So] Source:BMC Nephrol;18(1):144, 2017 May 01.
[Is] ISSN:1471-2369
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Poor physical performance and protein-energy wasting (PEW) are health issues of major concern in haemodialysis patients. The conventional haemodialysis (CHD) regime, three times per week 3-5 h, is subject of discussion because of high morbidity and mortality rates. When patients switch from CHD to longer dialysis sessions, i.e. nocturnal haemodialysis (NHD), improvement in protein intake and increase in body weight is seen. However, it is unclear whether physical performance and more important aspects of PEW, such as body composition, improve as well. Therefore, the aim of this study is to investigate whether physical performance improves and PEW decreases, when patients switch from CHD to NHD. A second aim is to assess the influence of NHD on the biomarkers fibroblast growth factor-23 and sclerostin which are thought to be associated with malnutrition and mortality in patients on haemodialysis. METHODS: This study is a prospective multicentre cohort study with an inclusion aim of 50 patients: 25 patients in a control group (three times per week, 3-5 h CHD) and 25 patients in a nocturnal group (three times per week, 7-9 h NHD). Primary outcome is change in physical performance, measured by the Short Physical Performance Battery. Additional measurements are a 6-min walk test, handgrip strength, a physical activity questionnaire and physical activity monitoring. The secondary outcome of the study is PEW, which will be evaluated by body weight, dual-energy X-ray absorptiometry, bio-electrical impedance spectroscopy, mid-upper arm muscle circumference, subjective global assessment, visual analogue scale for appetite and dietary records. Laboratory measurements including fibroblast growth factor-23 and sclerostin, and quality of life assessed with the Kidney Disease Quality of Life-Short Form are also studied. In every patient, four repeated measurements will be performed during one year of follow-up. DISCUSSION: This study will investigate whether physical performance improves and PEW decreases when patients switch from CHD to NHD, compared to a control group who continue treatment with CHD. Strengths of this study are the comparison with a conventional haemodialysis cohort, and the broad variety of objective measurements combined with patient-reported outcomes of physical performance and PEW. TRIAL REGISTRATION: NTR4715 , Netherlands Trial Register. Registered 30 July 2014.
[Mh] Termos MeSH primário: Falência Renal Crônica/complicações
Falência Renal Crônica/reabilitação
Aptidão Física
Desnutrição Proteico-Calórica/etiologia
Desnutrição Proteico-Calórica/prevenção & controle
Diálise Renal/efeitos adversos
Diálise Renal/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Peso Corporal
Feminino
Seres Humanos
Masculino
Meia-Idade
Países Baixos
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1186/s12882-017-0562-1


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[PMID]:29236703
[Au] Autor:Schulte-Herbrüggen B; Cowlishaw G; Homewood K; Rowcliffe JM
[Ad] Endereço:Zoological Society of London, Institute of Zoology, London, United Kingdom.
[Ti] Título:Rural protein insufficiency in a wildlife-depleted West African farm-forest landscape.
[So] Source:PLoS One;12(12):e0188109, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Wildlife is an important source of protein for many people in developing countries. Yet wildlife depletion due to overexploitation is common throughout the humid tropics and its effect on protein security, especially for vulnerable households, is poorly understood. This is problematic for both sustainable rural development and conservation management. METHODS: This study investigates a key dimension of protein security in a cash-crop farming community living in a wildlife-depleted farm-forest landscape in SW Ghana, a region where protein-energy malnutrition persists. Specifically, we monitored protein sufficiency, defined as whether consumption met daily requirements, as benchmarked by recommended daily allowance (RDA). We focus on whether more vulnerable households were less likely to be able to meet their protein needs, where vulnerability was defined by wealth, agricultural season and gender of the household head. Our central hypothesis was: (a) vulnerable households are less likely to consume sufficient protein. In the context that most plant proteins were home-produced, so likely relatively accessible to all households, while most animal proteins were purchased, so likely less accessible to vulnerable households, we tested two further hypotheses: (b) vulnerable households depend more on plant protein to cover their protein needs; and (c) vulnerable households are less likely to earn sufficient cash income to meet their protein needs through purchased animal sources. RESULTS: Between 14% and 60% of households (depending on plant protein content assumptions) consumed less than the RDA for protein, but neither protein consumption nor protein sufficiency co-varied with household vulnerability. Fish, livestock and food crops comprised 85% of total protein intake and strongly affected protein sufficiency. However, bushmeat remained an important protein source (15% of total consumption), especially during the post-harvest season when it averaged 26% of total protein consumption. Across the year, 89% of households experienced at least one occasion when they had insufficient income to cover their protein needs through animal protein purchases. The extent of this income shortage was highest during the lean season and among poorer households. CONCLUSIONS: These findings indicate that despite wildlife depletion, bushmeat continues to make a substantial contribution to protein consumption, especially during the agricultural lean season. Income shortages among farmers limit their ability to purchase bushmeat or its substitutes, suggesting that wildlife depletion may cause malnutrition.
[Mh] Termos MeSH primário: Animais Selvagens
Proteínas na Dieta/administração & dosagem
Fazendas
Florestas
Desnutrição Proteico-Calórica
População Rural
[Mh] Termos MeSH secundário: Animais
Gana
Seres Humanos
Fatores Socioeconômicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dietary Proteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188109


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[PMID]:28934453
[Au] Autor:Jones EN; Amoah S; Cao W; Sambhara S; Gangappa S
[Ad] Endereço:Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
[Ti] Título:An Adjuvanted A(H5N1) Subvirion Vaccine Elicits Virus-Specific Antibody Response and Improves Protection Against Lethal Influenza Viral Challenge in Mouse Model of Protein Energy Malnutrition.
[So] Source:J Infect Dis;216(suppl_4):S560-S565, 2017 Sep 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Protein energy malnutrition (PEM) increases susceptibility to infectious diseases, including influenza infection, but no studies have addressed the potential influences of PEM on the immunogenicity and protective efficacy of avian influenza A(H5N1) vaccine. Methods: We investigated the role of PEM on vaccine-mediated protection after a lethal challenge with recombinant A(H5N1) virus using isocaloric diets providing either adequate protein (AP; 18% protein) or very low protein (VLP; 2% protein) in an established murine model of influenza vaccination. Results: We demonstrated that mice maintained on a VLP diet succumb to lethal challenge at greater rates than mice maintained on an AP diet, despite comparable immunization regimens. Importantly, there was no virus-induced mortality in both VLP and AP groups of mice when either group was immunized with adjuvanted low-dose A(H5N1) subvirion vaccine. Conclusions: Our results suggest that adjuvanted vaccination in populations where PEM is endemic may be one strategy to boost vaccination-promoted immunity and improve outcomes associated with highly pathogenic A(H5N1).
[Mh] Termos MeSH primário: Adjuvantes Imunológicos/administração & dosagem
Formação de Anticorpos
Vacinas contra Influenza/administração & dosagem
Infecções por Orthomyxoviridae/prevenção & controle
Desnutrição Proteico-Calórica/imunologia
[Mh] Termos MeSH secundário: Animais
Dieta com Restrição de Proteínas/efeitos adversos
Proteínas na Dieta/administração & dosagem
Proteínas na Dieta/sangue
Modelos Animais de Doenças
Feminino
Testes de Inibição da Hemaglutinação
Vírus da Influenza A Subtipo H5N1/imunologia
Camundongos
Camundongos Endogâmicos C57BL
Desnutrição Proteico-Calórica/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (Dietary Proteins); 0 (Influenza Vaccines)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jiw585


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Chebli, Júlio Maria Fonseca
Texto completo SciELO Brasil
[PMID]:28724037
[Au] Autor:Santos JCD; Malaguti C; Lucca FA; Cabalzar AL; Ribeiro TCDR; Gaburri PD; Chebli LA; Chebli JMF
[Ad] Endereço:Department of Internal Medicine, Faculdade de Medicina da Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil.
[Ti] Título:Impact of biological therapy on body composition of patients with Chron's disease.
[So] Source:Rev Assoc Med Bras (1992);63(5):407-413, 2017 May.
[Is] ISSN:1806-9282
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Introduction:: Protein-energy malnutrition in Crohn's disease (CD) has been reported in 20 to 92% of patients, and is associated with increased morbidity and mortality and higher costs for the health system. Anti-TNF drugs are a landmark in the clinical management, promoting prolonged remission in patients with CD. It is believed that the remission of this disease leads to nutritional recovery. The effect of biological therapy on body composition and nutritional status is unclear. Method:: Prospective study of body assessment by bioelectrical impedance method in patients with moderate to severe CD undergoing treatment with infliximab. The main outcome was the body composition before and after 6 months of anti-TNF therapy. Results:: There was a predominance of females (52%) with a mean age of 42±12 years. Most patients were eutrophic at baseline and remained so. There was an increase in all parameters of body composition after anti-TNF treatment: BMI (22.9±3.2 versus 25±3.8; p=0.005), waist circumference (88.1±6.7 versus 93.9±7.7; p=0.002), lean mass index (17.5±2.2 versus 18.2±2.3; p=0.000) and fat mass index (5.5±2.3 versus 6.8±2.3; p=0.000). Phase angle remained unchanged (6.2 versus 6.8; p=0.94). Conclusion:: After therapy with IFX, all components of body composition increased, except for phase angle. The substantial increase in fat mass index and waist circumference led to concern regarding cardiovascular risk and, thus, to the need for further studies.
[Mh] Termos MeSH primário: Composição Corporal/efeitos dos fármacos
Doença de Crohn/tratamento farmacológico
Fármacos Gastrointestinais/uso terapêutico
Infliximab/uso terapêutico
Fator de Necrose Tumoral alfa/antagonistas & inibidores
[Mh] Termos MeSH secundário: Adulto
Antropometria
Doença de Crohn/fisiopatologia
Impedância Elétrica
Exercício/fisiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Estado Nutricional
Estudos Prospectivos
Desnutrição Proteico-Calórica/prevenção & controle
Reprodutibilidade dos Testes
Índice de Gravidade de Doença
Estatísticas não Paramétricas
Inquéritos e Questionários
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gastrointestinal Agents); 0 (Tumor Necrosis Factor-alpha); B72HH48FLU (Infliximab)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE


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[PMID]:28723979
[Au] Autor:Nunes G; Santos CA; Barosa R; Fonseca C; Barata AT; Fonseca J
[Ad] Endereço:Hospital Garcia de Orta, Departamento de Gastroenterologia, GENE - Artificial Feeding Team, Almada, Portugal.
[Ti] Título:OUTCOME AND NUTRITIONAL ASSESSMENT OF CHRONIC LIVER DISEASE PATIENTS USING ANTHROPOMETRY AND SUBJECTIVE GLOBAL ASSESSMENT.
[So] Source:Arq Gastroenterol;54(3):225-231, 2017 Jul-Sept.
[Is] ISSN:1678-4219
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:BACKGROUND:: Protein-calorie malnutrition is common in chronic liver disease (CLD) but adequate clinical tools for nutritional assessment are not defined. OBJECTIVE:: In CLD patients, it was aimed: 1. Characterize protein-calorie malnutrition; 2. Compare several clinical, anthropometric and functional tools; 3. Study the association malnutrition/CLD severity and malnutrition/outcome. METHODS:: Observational, prospective study. Consecutive CLD ambulatory/hospitalised patients were recruited from 01-03-2012 to 31-08-2012, studied according with age, gender, etiology, alcohol consumption and CLD severity defined by Child-Turcotte-Pugh. Nutritional assessment used subjective global assessment, anthropometry, namely body-mass index (BMI), triceps skinfold, mid upper arm circumference, mid arm muscular circumference and handgrip strength. Patients were followed during two years and survival data was recorded. RESULTS:: A total of 130 CLD patients (80 men), aged 22-89 years (mean 60 years) were included. Most suffered from alcoholic cirrhosis (45%). Hospitalised patients presented more severe disease ( P <0.001) and worst nutritional status defined by BMI ( P =0.002), mid upper arm circumference ( P <0.001), mid arm muscular circumference ( P <0.001), triceps skinfold ( P =0.07) and subjective global assessment ( P <0.001). A third presented deficient/low handgrip strength. Alcohol consumption ( P =0.03) and malnutrition detected by BMI ( P =0.03), mid upper arm circumference ( P =0.001), triceps skinfold ( P =0.06), mid arm muscular circumference ( P =0.02) and subjective global assessment ( P <0.001) were associated with CLD severity. From 25 patients deceased during follow-up, 17 patients were severely malnourished according with triceps skinfold. Malnutrition defined by triceps skinfold predicted mortality ( P <0.001). CONCLUSION:: Protein-calorie malnutrition is common in CLD patients and alcohol plays an important role. Triceps skinfold is the most efficient anthropometric parameter and is associated with mortality. Nutritional assessment should be considered mandatory in the routine care of CLD patients.
[Mh] Termos MeSH primário: Hepatopatias/complicações
Desnutrição Proteico-Calórica/etiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Índice de Massa Corporal
Doença Crônica
Feminino
Seguimentos
Seres Humanos
Hepatopatias/mortalidade
Masculino
Meia-Idade
Avaliação Nutricional
Estudos Prospectivos
Desnutrição Proteico-Calórica/mortalidade
Índice de Gravidade de Doença
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE


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[PMID]:28538943
[Au] Autor:Santos CA; Fonseca J; Carolino E; Guerreiro AS
[Ad] Endereço:GENE - Enteral Feeding Team. Hospital Garcia de Orta, Portugal.
[Ti] Título:LOW SERUM CHROMIUM IS RARE IN PATIENTS THAT UNDERWENT ENDOSCOPIC GASTROSTOMY FOR LONG TERM ENTERAL FEEDING.
[So] Source:Arq Gastroenterol;54(3):211-216, 2017 Jul-Sept.
[Is] ISSN:1678-4219
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Patients that underwent Percutaneous Endoscopic Gastrostomy (PEG) present with protein-energy malnutrition. Trace elements are required in small quantities and Chromium (Cr) displays a major role in the metabolism. OBJECTIVE: This study aims to evaluate Cr levels and its relationship with serum proteins, BMI and underlying diseases during the first 3 months of PEG feeding. METHODS: Prospective observational study during 3-months, when PEG was performed (T0), after 4 (T1), and 12 weeks (T3). Initial evaluation included: age, gender, underlying disease, NRS-2002, BMI, serum albumin, transferrin and Cr concentration. At T1 and T3 a blood sample was collected for Cr, albumin and transferrin. A Graphite Furnace Atomic Absorption Spectroscopy was used to assess Cr. According with the underlying disease, patients were divided into two groups: head and neck cancer (HNC) and neurological dysphagia (ND). All patients were fed with homemade meals. RESULTS: A one hundred and twenty-nine patients (80 males), 26-95 years old were studied: HNC-52; ND-77. The observed data included low mean values of BMI from 71 patients; low Cr-8, low albumin-70, low transferrin-85 and 57 with both proteins low. Albumin was associated with survival time ( P =0.024) and there was a significant correlation between albumin and Cr (r=0.217, P =0.012). A good evolution of Cr and proteins values was observed, with no low Cr levels at T3. CONCLUSION: Low serum Cr is rare in PEG-patients, with no relationship to other studied parameters. For the minority of patients displaying low Cr before gastrostomy, homemade PEG meals seem to be effective.
[Mh] Termos MeSH primário: Cromo/sangue
Nutrição Enteral
Gastrostomia/efeitos adversos
Desnutrição Proteico-Calórica/sangue
Desnutrição Proteico-Calórica/etiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Índice de Massa Corporal
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0R0008Q3JB (Chromium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170525
[St] Status:MEDLINE


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[PMID]:28520899
[Au] Autor:Bolick DT; Mayneris-Perxachs J; Medlock GL; Kolling GL; Papin JA; Swann JR; Guerrant RL
[Ad] Endereço:Division of Infectious Diseases and International Health, UVA Center for Global Health, University of Virginia, Charlottesville.
[Ti] Título:Increased Urinary Trimethylamine N-Oxide Following Cryptosporidium Infection and Protein Malnutrition Independent of Microbiome Effects.
[So] Source:J Infect Dis;216(1):64-71, 2017 Jul 01.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cryptosporidium infections have been associated with growth stunting, even in the absence of diarrhea. Having previously detailed the effects of protein deficiency on both microbiome and metabolome in this model, we now describe the specific gut microbial and biochemical effects of Cryptosporidium infection. Protein-deficient mice were infected with Cryptosporidium parvum oocysts for 6-13 days and compared with uninfected controls. Following infection, there was an increase in the urinary excretion of choline- and amino-acid-derived metabolites. Conversely, infection reduced the excretion of the microbial-host cometabolite (3-hydroxyphenyl)propionate-sulfate and disrupted metabolites involved in the tricarboxylic acid (TCA) cycle. Correlation analysis of microbial and biochemical profiles resulted in associations between various microbiota members and TCA cycle metabolites, as well as some microbial-specific degradation products. However, no correlation was observed between the majority of the infection-associated metabolites and the fecal bacteria, suggesting that these biochemical perturbations are independent of concurrent changes in the relative abundance of members of the microbiota. We conclude that cryptosporidial infection in protein-deficient mice can mimic some metabolic changes seen in malnourished children and may help elucidate our understanding of long-term metabolic consequences of early childhood enteric infections.
[Mh] Termos MeSH primário: Criptosporidiose/urina
Microbioma Gastrointestinal
Metilaminas/urina
Desnutrição Proteico-Calórica/urina
[Mh] Termos MeSH secundário: Animais
Biomarcadores/urina
Ciclo do Ácido Cítrico
Criptosporidiose/diagnóstico
Criptosporidiose/microbiologia
Cryptosporidium parvum/isolamento & purificação
Fezes/microbiologia
Lipocalina-2/genética
Lipocalina-2/metabolismo
Masculino
Metaboloma
Camundongos
Camundongos Endogâmicos
Peroxidase/genética
Peroxidase/metabolismo
Desnutrição Proteico-Calórica/microbiologia
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Lipocalin-2); 0 (Methylamines); 126469-30-5 (Lcn2 protein, mouse); EC 1.11.1.7 (Peroxidase); FLD0K1SJ1A (trimethyloxamine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix234


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[PMID]:28420212
[Au] Autor:Kang SS; Chang JW; Park Y
[Ad] Endereço:Department of Dietetics and Nutrition Service, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea. sskang@amc.seoul.kr.
[Ti] Título:Nutritional Status Predicts 10-Year Mortality in Patients with End-Stage Renal Disease on Hemodialysis.
[So] Source:Nutrients;9(4), 2017 Apr 18.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Protein-energy wasting (PEW) is associated with mortality in patients with end-stage renal disease (ESRD) on maintenance hemodialysis. The correct diagnosis of PEW is extremely important in order to predict clinical outcomes. However, it is unclear which parameters should be used to diagnose PEW. Therefore, this retrospective observational study investigated the relationship between mortality and nutritional parameters in ESRD patients on maintenance hemodialysis. A total of 144 patients were enrolled. Nutritional parameters, including body mass index, serum albumin, dietary intake, normalized protein catabolic rate (nPCR), and malnutrition inflammation score (MIS), were measured at baseline. Fifty-three patients died during the study. Survivors had significantly higher nPCR (1.10 ± 0.24 g/kg/day vs. 1.01 ± 0.21 g/kg/day; = 0.048), energy intake (26.7 ± 5.8 kcal/kg vs. 24.3 ± 4.2 kcal/kg; = 0.009) and protein intake (0.91 ± 0.21 g/kg vs. 0.82 ± 0.24 g/kg; = 0.020), and lower MIS (5.2 ± 2.3 vs. 6.1 ± 2.1, = 0.039). In multivariable analysis, energy intake <25 kcal/kg (HR 1.860, 95% CI 1.018-3.399; = 0.044) and MIS > 5 (HR 2.146, 95% CI 1.173-3.928; = 0.013) were independent variables associated with all-cause mortality. These results suggest that higher MIS and lower energy intake are harmful to ESRD patients on maintenance hemodialysis. Optimal energy intake could reduce mortality in these patients.
[Mh] Termos MeSH primário: Proteínas na Dieta
Ingestão de Energia
Inflamação/mortalidade
Falência Renal Crônica/mortalidade
Estado Nutricional
Desnutrição Proteico-Calórica/mortalidade
Diálise Renal/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Índice de Massa Corporal
Causas de Morte
Proteínas na Dieta/administração & dosagem
Proteínas na Dieta/metabolismo
Feminino
Seres Humanos
Inflamação/etiologia
Falência Renal Crônica/terapia
Masculino
Meia-Idade
Análise Multivariada
Avaliação Nutricional
Desnutrição Proteico-Calórica/etiologia
Estudos Retrospectivos
Fatores de Risco
Albumina Sérica
Síndrome de Emaciação/etiologia
Síndrome de Emaciação/mortalidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Dietary Proteins); 0 (Serum Albumin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE


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[PMID]:28394304
[Au] Autor:Piccoli GB; Moio MR; Fois A; Sofronie A; Gendrot L; Cabiddu G; D'Alessandro C; Cupisti A
[Ad] Endereço:Dipartimento di Scienze Cliniche e Biologiche, University of Torino, 10100 Torino, Italy. gbpiccoli@yahoo.it.
[Ti] Título:The Diet and Haemodialysis Dyad: Three Eras, Four Open Questions and Four Paradoxes. A Narrative Review, Towards a Personalized, Patient-Centered Approach.
[So] Source:Nutrients;9(4), 2017 Apr 10.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The history of dialysis and diet can be viewed as a series of battles waged against potential threats to patients' lives. In the early years of dialysis, potassium was identified as "the killer", and the lists patients were given of forbidden foods included most plant-derived nourishment. As soon as dialysis became more efficient and survival increased, hyperphosphatemia, was identified as the enemy, generating an even longer list of banned aliments. Conversely, the "third era" finds us combating protein-energy wasting. This review discusses four questions and four paradoxes, regarding the diet-dialysis dyad: are the "magic numbers" of nutritional requirements (calories: 30-35 kcal/kg; proteins > 1.2 g/kg) still valid? Are the guidelines based on the metabolic needs of patients on "conventional" thrice-weekly bicarbonate dialysis applicable to different dialysis schedules, including daily dialysis or haemodiafiltration? The quantity of phosphate and potassium contained in processed and preserved foods may be significantly different from those in untreated foods: what are we eating? Is malnutrition one condition or a combination of conditions? The paradoxes: obesity is associated with higher survival in dialysis, losing weight is associated with mortality, but high BMI is a contraindication for kidney transplantation; it is difficult to limit phosphate intake when a patient is on a high-protein diet, such as the ones usually prescribed on dialysis; low serum albumin is associated with low dialysis efficiency and reduced survival, but on haemodiafiltration, high efficiency is coupled with albumin losses; banning plant derived food may limit consumption of "vascular healthy" food in a vulnerable population. Tailored approaches and agreed practices are needed so that we can identify attainable goals and pursue them in our fragile haemodialysis populations.
[Mh] Termos MeSH primário: Dietoterapia/efeitos adversos
Medicina Baseada em Evidências
Comunicação Interdisciplinar
Assistência Centrada no Paciente
Diálise Renal/efeitos adversos
Insuficiência Renal Crônica/dietoterapia
Insuficiência Renal Crônica/terapia
[Mh] Termos MeSH secundário: Terapia Combinada/efeitos adversos
Terapia Combinada/tendências
Contraindicações
Dietoterapia/tendências
Progressão da Doença
Seres Humanos
Falência Renal Crônica/complicações
Falência Renal Crônica/etiologia
Falência Renal Crônica/prevenção & controle
Falência Renal Crônica/cirurgia
Transplante de Rim/efeitos adversos
Transplante de Rim/tendências
Necessidades Nutricionais
Obesidade/complicações
Assistência Centrada no Paciente/tendências
Desnutrição Proteico-Calórica/etiologia
Desnutrição Proteico-Calórica/prevenção & controle
Diálise Renal/tendências
Insuficiência Renal Crônica/complicações
Insuficiência Renal Crônica/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE


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[PMID]:28353243
[Au] Autor:Ma D; Ozanne SE; Guest PC
[Ad] Endereço:Department of neurosciences, University of Cambridge, Clifford Allbutt building, Hills road, Cambridge, CB2 0AH, UK.
[Ti] Título:A Protocol for Producing the Maternal Low-Protein Rat Model: A Tool for Preclinical Proteomic Studies.
[So] Source:Adv Exp Med Biol;974:251-255, 2017.
[Is] ISSN:0065-2598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Epidemiological studies have shown that periods of poor nutrition during pregnancy can lead to an increased risk of metabolic and psychiatric disorders in the offspring. In addition, some individuals with disorders such as schizophrenia show signs of impaired insulin signalling. These findings indicate that there may be a link between metabolism and neuronal function and they also provide supporting evidence for neurodevelopmental origins of mental illness. This chapter gives a detailed protocol for generation of the maternal low-protein (LP) rat model, which leads to metabolic disturbances in the offspring. This model has been used in proteomic studies of several disorders including schizophrenia.
[Mh] Termos MeSH primário: Dieta com Restrição de Proteínas/efeitos adversos
Modelos Animais de Doenças
Complicações na Gravidez/fisiopatologia
Efeitos Tardios da Exposição Pré-Natal
Desnutrição Proteico-Calórica/fisiopatologia
Esquizofrenia/etiologia
[Mh] Termos MeSH secundário: Animais
Animais Lactentes
Feminino
Lactação
Gravidez
Complicações na Gravidez/etiologia
Desnutrição Proteico-Calórica/etiologia
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE
[do] DOI:10.1007/978-3-319-52479-5_22



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