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  1 / 8510 MEDLINE  
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[PMID]:28454925
[Au] Autor:Kalra B; Tamang AM; Parkash R
[Ad] Endereço:Department of Genetics, M. D. University, Rohtak 124001, India.
[Ti] Título:Cross-tolerance effects due to adult heat hardening, desiccation and starvation acclimation of tropical drosophilid-Zaprionus indianus.
[So] Source:Comp Biochem Physiol A Mol Integr Physiol;209:65-73, 2017 07.
[Is] ISSN:1531-4332
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Some insect taxa from polar or temperate habitats have shown cross-tolerance for multiple stressors but tropical insect taxa have received less attention. Accordingly, we considered adult flies of a tropical drosophilid-Zaprionus indianus for testing direct as well as cross-tolerance effects of rapid heat hardening (HH), desiccation acclimation (DA) and starvation acclimation (SA) after rearing under warmer and drier season specific simulated conditions. We observed significant direct acclimation effects of HH, DA and SA; and four cases of cross-tolerance effects but no cross-tolerance between desiccation and starvation. Cross-tolerance due to heat hardening on desiccation showed 20% higher effect than its reciprocal effect. There is greater reduction of water loss in heat hardened flies (due to increase in amount of cuticular lipids) as compared with desiccation acclimated flies. However, cross-tolerance effect of SA on heat knockdown was two times higher than its reciprocal. Heat hardened and desiccation acclimated adult flies showed substantial increase in the level of trehalose and proline while body lipids increased due to heat hardening or starvation acclimation. However, maximum increase in energy metabolites was stressor specific i.e. trehalose due to DA; proline due to HH and total body lipids due to SA. Rapid changes in energy metabolites due to heat hardening seem compensatory for possible depletion of trehalose and proline due to desiccation stress; and body lipids due to starvation stress. Thus, observed cross-tolerance effects in Z. indianus represent physiological changes to cope with multiple stressors related to warmer and drier subtropical habitats.
[Mh] Termos MeSH primário: Aclimatação/fisiologia
Drosophila/fisiologia
Metabolismo Energético
Trealose/metabolismo
[Mh] Termos MeSH secundário: Animais
Drosophila/metabolismo
Ecossistema
Temperatura Alta
Pigmentação/fisiologia
Estações do Ano
Inanição
Estresse Fisiológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
B8WCK70T7I (Trehalose)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


  2 / 8510 MEDLINE  
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[PMID]:29244064
[Au] Autor:Boland BB; Brown C; Alarcon C; Demozay D; Grimsby JS; Rhodes CJ
[Ad] Endereço:Kovler Diabetes Center, Department of Medicine Section of Endocrinology, Diabetes and Metabolism, University of Chicago, Chicago, Illinois.
[Ti] Título:ß-Cell Control of Insulin Production During Starvation-Refeeding in Male Rats.
[So] Source:Endocrinology;159(2):895-906, 2018 02 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mammalian metabolism has evolved to adapt to changes in nutrient status. Insulin, the key anabolic hormone, facilitates intracellular storage of nutrient fuels and plays a pivotal role in the transition away from catabolism upon refeeding. Although circulating insulin relative to nutrient levels has been well characterized during fasting and refeeding, how pancreatic ß-cell biology caters to acute changes in insulin demand has not been sufficiently addressed. Here, we examined the dynamics of (pro)insulin production and associated changes in ß-cell ultrastructure during refeeding after a 72-hour fast in male rats. We found that fasted ß-cells had marked degranulation, which inversely coordinated with the upregulation of autophagolysomal and lysosomal organelles. There was also expanded Golgi that correlated with enhanced (pro)insulin biosynthetic capacity but, conversely, blunted in vivo insulin secretion. Within 4 to 6 hours of refeeding, proinsulin biosynthesis, cellular ultrastructure, in vivo insulin secretion, and glucose tolerance normalized to levels near those of fed control animals, indicating a rapid replenishment of normal insulin secretory capacity. Thus, during a prolonged fast, the ß-cell protects against hypoglycemia by markedly reducing insulin secretory capacity in vivo but is simultaneously poised to efficiently increase (pro)insulin production upon refeeding to effectively return normal insulin secretory capacity within hours.
[Mh] Termos MeSH primário: Ingestão de Alimentos/fisiologia
Jejum/fisiologia
Células Secretoras de Insulina/metabolismo
Insulina/metabolismo
Inanição/metabolismo
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Masculino
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Insulin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-03120


  3 / 8510 MEDLINE  
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[PMID]:28452181
[Au] Autor:Hossain N
[Ad] Endereço:Research Fellow, Institute of Development Studies at the University of Sussex, United Kingdom.
[Ti] Título:The 1970 Bhola cyclone, nationalist politics, and the subsistence crisis contract in Bangladesh.
[So] Source:Disasters;42(1):187-203, 2018 Jan.
[Is] ISSN:1467-7717
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The devastating Bhola cyclone in November 1970 is credited with having triggered the political events that led to the division of Pakistan and the creation of Bangladesh in 1971. A callous response to the disaster by the Pakistani regime resulted in a landslide electoral victory for Bengali nationalists, followed by a bitter and bloody civil war. Yet, despite its political momentousness, the Bhola cyclone has been the subject of little political analysis. This paper examines the events, arguing that its extraordinary political significance put disaster management on the nationalist agenda; the famine of 1974 confirmed its centrality, producing a social contract to protect the population against disasters and subsistence crises on which the country's acclaimed resilience to the effects of climate change rests. The Bhola cyclone also drew international attention to this neglected, little-known region, and in general can be seen as foundational for the subsequent developmental achievements of Bangladesh.
[Mh] Termos MeSH primário: Tempestades Ciclônicas
Planejamento em Desastres
Política
Inanição
[Mh] Termos MeSH secundário: Bangladesh
Seres Humanos
Paquistão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1111/disa.12235


  4 / 8510 MEDLINE  
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[PMID]:27771939
[Au] Autor:Hoffmann L; Schummer A; Reimann J; Haurat MF; Wilson AJ; Beeby M; Warscheid B; Albers SV
[Ad] Endereço:Molecular Biology of Archaea, Institute of Biology II, Faculty of Biology, Microbiology, University of Freiburg, Freiburg, Germany.
[Ti] Título:Expanding the archaellum regulatory network - the eukaryotic protein kinases ArnC and ArnD influence motility of Sulfolobus acidocaldarius.
[So] Source:Microbiologyopen;6(1), 2017 02.
[Is] ISSN:2045-8827
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Expression of the archaellum, the archaeal-type IV pilus-like rotating motility structure is upregulated under nutrient limitation. This is controlled by a network of regulators, called the archaellum regulatory network (arn). Several of the components of this network in Sulfolobus acidocaldarius can be phosphorylated, and the deletion of the phosphatase PP2A results in strongly increased motility during starvation, indicating a role for phosphorylation in the regulation of motility. Analysis of the motility of different protein kinase deletion strains revealed that deletion of saci_0965, saci_1181, and saci_1193 resulted in reduced motility, whereas the deletion of saci_1694 resulted in hypermotility. Here ArnC (Saci_1193) and ArnD (Saci_1694) are characterized. Purified ArnC and ArnD phosphorylate serine and threonine residues in the C-terminus of the repressor ArnB. arnC is upregulated in starvation medium, whereas arnD is constitutively expressed. However, while differences in the expression and levels of flaB were observed in the ΔarnD strain during growth under rich conditions, under nutrient limiting conditions the ΔarnC and ΔarnD strains showed no large differences in the expression levels of the archaellum or of the studied regulators. This suggests that next to the regulation via the archaellum regulatory network additional regulatory mechanisms of expression and/or activity of the archaellum exist.
[Mh] Termos MeSH primário: Proteínas Arqueais/metabolismo
Flagelos/metabolismo
Regulação da Expressão Gênica em Archaea
Proteínas Quinases/metabolismo
Sulfolobus acidocaldarius/metabolismo
[Mh] Termos MeSH secundário: Proteínas Arqueais/genética
Flagelos/genética
Deleção de Genes
Fosforilação
Domínios Proteicos
Proteínas Quinases/genética
Transdução de Sinais/fisiologia
Inanição
Sulfolobus acidocaldarius/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Archaeal Proteins); EC 2.7.- (Protein Kinases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1002/mbo3.414


  5 / 8510 MEDLINE  
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[PMID]:29175212
[Au] Autor:Wang Z; Yang F; Jiang Y; Wang R; Chen X; Lv J; Li C; Sun X; Li J; Wang S
[Ad] Endereço:Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150081, PR China.
[Ti] Título:Role of pyroptosis in normal cardiac response to calorie restriction and starvation.
[So] Source:Biochem Biophys Res Commun;495(1):1122-1128, 2018 01 01.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AIMS: An unhealthy diet is a major risk factor for cardiac diseases. Most researches focus on high fat diet, little is known about the detrimental effects of starvation on heart. METHODS: Mice were fed 100%, 40% and 20% of ad libitum to mimic the situation of moderate and severe caloric restriction (CR). To further evaluate the different effect of CR and starvation on cardiomyocyte, AC16 cells were treated with different concentrations of serum or glucose. TUNEL staining was performed to evaluate DNA damage in AC16 cells. HE and Masson staining were performed to detect the morphology and degree of fibrosis in myocardium from mice. Immunohistochemical staining, immunofluorescence staining, western blot and real-time PCR were used to detect the protein and mRNA expression of caspase-1, IL-1ß and IL-18. RESULTS: CR and starvation decrease body weight of mice in a concentration dependent manner. The starvation group showed a remarkable myocardial fibrosis with no significant alteration between control and CR groups. CR inhibited the activation of caspase-1 as well as the expression of IL-1ß and IL-18. On the contrary, starvation plays completely opposite effects, which was in accordance with histological changes. Similarly, different levels of serum and glucose deprivation were used to mimic the effect of CR and starvation in vitro. Moderate level of serum and glucose deprivation exerts protective effect on AC16 cells through the inhibition of pyroptosis, whereas high level of serum and glucose deprivation induces cell injury through the induction of pyroptosis. CONCLUSION: CR alleviates pyroptosis, whereas starvation promotes the progression of pyroptosis in myocardial tissues and cells.
[Mh] Termos MeSH primário: Restrição Calórica/métodos
Coração/fisiopatologia
Miocárdio/patologia
Piroptose
Inanição/patologia
Inanição/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Peso Corporal
Masculino
Camundongos
Camundongos Endogâmicos C57BL
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  6 / 8510 MEDLINE  
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[PMID]:29020043
[Au] Autor:Laetz EMJ; Wägele H
[Ad] Endereço:Center for Molecular Biodiversity Research (ZMB), Zoological Research Museum Alexander Koenig Adenauerallee 160 Bonn, Germany.
[Ti] Título:Chloroplast digestion and the development of functional kleptoplasty in juvenile Elysia timida (Risso, 1818) as compared to short-term and non-chloroplast-retaining sacoglossan slugs.
[So] Source:PLoS One;12(10):e0182910, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sacoglossan sea slugs are the only metazoans known to perform functional kleptoplasty, the sequestration and retention of functional chloroplasts within their digestive gland cells. Remarkably, a few species with this ability can survive starvation periods of 3-12 months likely due to their stolen chloroplasts. There are no reports of kleptoplast transfer from mother slug to either eggs or juveniles, demonstrating that each animal must independently acquire its kleptoplasts and develop the ability to maintain them within its digestive gland. We present here an investigation into the development of functional kleptoplasty in a long-term kleptoplast retaining species, Elysia timida. Laboratory-reared juvenile slugs of different post-metamorphic ages were placed in starvation and compared to 5 known short-term retaining slug species and 5 non-retaining slug species. The subsequent results indicate that functional kleptoplasty is not performed by E. timida until after 15 days post-metamorphosis and that by 25 days, these animals outlive many of the short-term retention species. Digestive activity was also monitored using lysosomal abundance as an indicator, revealing different patterns in starving juveniles versus adults. Starved juveniles were reintroduced to food to determine any differences in digestive activity when starvation ends, resulting in an increase in the number of kleptoplasts, but no overall change in lysosomal activity. By revealing some of the changes that occur during early development in these animals, which begin as non-kleptoplast-retaining and grow into long-term retaining slugs, this investigation provides a basis for future inquiries into the origin and development of this remarkable ability.
[Mh] Termos MeSH primário: Cloroplastos/metabolismo
Digestão/fisiologia
Gastrópodes/fisiologia
[Mh] Termos MeSH secundário: Animais
Clorofila/metabolismo
Comportamento Alimentar
Fluorometria
Longevidade
Lisossomos/metabolismo
Metamorfose Biológica
Microscopia Confocal
Especificidade da Espécie
Manejo de Espécimes
Inanição/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
1406-65-1 (Chlorophyll); YF5Q9EJC8Y (chlorophyll a)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182910


  7 / 8510 MEDLINE  
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[PMID]:28939196
[Au] Autor:Zhang H; Shi Y; He M
[Ad] Endereço:CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; University of Chinese Academy of Sciences, Beijing 100049, China.
[Ti] Título:Molecular identification of an insulin growth factor binding protein (IGFBP) and its potential role in an insulin-like peptide system of the pearl oyster, Pinctada fucata.
[So] Source:Comp Biochem Physiol B Biochem Mol Biol;214:27-35, 2017 Dec.
[Is] ISSN:1879-1107
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Insulin-like growth factors (IGFs) play critical roles in regulating metabolism, growth, and reproduction in invertebrates. IGF binding proteins (IGFBPs) serve as major regulators of IGF activity and regulate endocrine system. In the present study, the full-length cDNA of an igfbp was identified from the pearl oyster, Pinctada fucata, using expressed sequence tag (EST) sequence. The 1124bp Pfigfbp cDNA contains a 465bp open reading frame (ORF) encoding a putative protein of 154 amino acids, a 5'-untranslated region (UTR) of 238bp, and a 3'-UTR of 394bp (not including polyA+). Multiple sequence alignment of the deduced IB domain sequences revealed that twelve conserved Cys and ILP binding site in PfIGFBP were well aligned with human IGFBPs1-7, Mizuhopecten yessoensis IGFBP5 and Eriocheir sinensis IGFBP7. Gene expression analysis indicated that Pfigfbp mRNA was expressed in all the tissues and developmental stages examined, with a higher level in the foot than in other tissues and a higher level in the polar body stage and 32-cell stage than in the other stages. Pfigfbp and PfILP (insulin-like peptide) mRNA levels significantly increased in the digestive gland after feeding, while levels were dramatically reduced during a week of food deprivation and increased upon refeeding. In vitro experiments indicated that Pfigfbp mRNA expression in mantle cells was affected by insulin/IGFs (IGF-I, IGF-II). Our data suggests that Pfigfbp may be involved in endocrine signaling in P. fucata via the regulation of insulin-like peptide signaling.
[Mh] Termos MeSH primário: Regulação da Expressão Gênica no Desenvolvimento
Proteínas de Ligação a Fator de Crescimento Semelhante a Insulina/genética
Insulina/genética
Fases de Leitura Aberta
Pinctada/genética
Somatomedinas/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Sítios de Ligação
Clonagem Molecular
Ingestão de Alimentos/genética
Escherichia coli/genética
Escherichia coli/metabolismo
Etiquetas de Sequências Expressas/química
Seres Humanos
Insulina/metabolismo
Proteínas de Ligação a Fator de Crescimento Semelhante a Insulina/metabolismo
Especificidade de Órgãos
Pectinidae
Filogenia
Pinctada/classificação
Pinctada/crescimento & desenvolvimento
Pinctada/metabolismo
Ligação Proteica
Domínios e Motivos de Interação entre Proteínas
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
Alinhamento de Sequência
Homologia de Sequência de Aminoácidos
Transdução de Sinais
Somatomedinas/metabolismo
Inanição/genética
Inanição/metabolismo
Regiões não Traduzidas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insulin); 0 (Insulin-Like Growth Factor Binding Proteins); 0 (Recombinant Proteins); 0 (Somatomedins); 0 (Untranslated Regions)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170924
[St] Status:MEDLINE


  8 / 8510 MEDLINE  
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[PMID]:28886062
[Au] Autor:Sacristán HJ; Rodríguez YE; De Los Angeles Pereira N; López Greco LS; Lovrich GA; Fernández Gimenez AV
[Ad] Endereço:Centro Austral de Investigaciones Científicas, CONICET, Houssay, Ushuaia, Argentina.
[Ti] Título:Energy reserves mobilization: Strategies of three decapod species.
[So] Source:PLoS One;12(9):e0184060, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In food deprivation assays, several different responses have been observed in crustaceans. However, studying energy reserves utilization among more than one species during the same starvation period has not yet been performed, particularly to discern whether the responses are due to intrinsic and/or environmental factors. We hypothesize that decapod species with similar feeding habits have the same strategies in the use of energetic reserves during starvation, even though they inhabit different environments. The aim of this study was to compare the energy reserves mobilization of three decapods species (Cherax quadricarinatus, Palaemon argentinus and Munida gregaria) with similar feeding habits, exposed to similar food deprivation conditions. The crayfish, shrimp and squat-lobster were experimentally kept at continuous feeding or continuous starvation throughout 15 days. Every 3rd day, the midgut gland index (MGI), and the glycogen, lipid and protein contents were measured in the midgut gland (MG) and pleon muscle. Palaemon argentinus mobilized more reserves during starvation, followed by C. quadricarinatus, and the last M. gregaria. The starved shrimps presented low MGI, whereas MG showed a reduction in glycogen (from day 6 to 15), lipid (from day 3 to 15), and protein levels (at day 9 and 15) while in their muscle, lipid reserves decreased at days 3 and 6. In C. quadricarinatus, the most affected parameters in the MG were MGI, glycogen (from day 6 to 15), and lipids (at day 12 and 15). In the MG of M. gregaria only the glycogen was reduced during fasting from 3 to 15 days. Even though the three studied species have similar feeding habitats, we found that their energetic profile utilization is different and it could be explained by the habitat, life span, temperature, organ/tissue, and metabolism of the species. Our results may be useful to understand the several different responses of crustaceans during starvation.
[Mh] Termos MeSH primário: Crustáceos/fisiologia
Metabolismo Energético
Privação de Alimentos
[Mh] Termos MeSH secundário: Animais
Astacoidea/fisiologia
Crustáceos/classificação
Meio Ambiente
Glicogênio/metabolismo
Metabolismo dos Lipídeos
Músculos/metabolismo
Filogenia
Inanição
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9005-79-2 (Glycogen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184060


  9 / 8510 MEDLINE  
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[PMID]:28826372
[Au] Autor:Newman JC; Verdin E
[Ad] Endereço:Buck Institute for Research on Aging, Novato, California 94945; email: newman@ucsf.edu , everdin@buckinstitute.org.
[Ti] Título:ß-Hydroxybutyrate: A Signaling Metabolite.
[So] Source:Annu Rev Nutr;37:51-76, 2017 Aug 21.
[Is] ISSN:1545-4312
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Various mechanisms in the mammalian body provide resilience against food deprivation and dietary stress. The ketone body ß-hydroxybutyrate (BHB) is synthesized in the liver from fatty acids and represents an essential carrier of energy from the liver to peripheral tissues when the supply of glucose is too low for the body's energetic needs, such as during periods of prolonged exercise, starvation, or absence of dietary carbohydrates. In addition to its activity as an energetic metabolite, BHB is increasingly understood to have cellular signaling functions. These signaling functions of BHB broadly link the outside environment to epigenetic gene regulation and cellular function, and their actions may be relevant to a variety of human diseases as well as human aging.
[Mh] Termos MeSH primário: Ácido 3-Hidroxibutírico/metabolismo
Transdução de Sinais
[Mh] Termos MeSH secundário: Envelhecimento
Animais
Epigênese Genética
Seres Humanos
Fígado/metabolismo
Inanição
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
TZP1275679 (3-Hydroxybutyric Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.1146/annurev-nutr-071816-064916


  10 / 8510 MEDLINE  
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[PMID]:28807780
[Au] Autor:Jeong H; Paik YK
[Ad] Endereço:Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea; Department of Integrative Omics for Biomedical Science, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.
[Ti] Título:MGL-1 on AIY neurons translates starvation to reproductive plasticity via neuropeptide signaling in Caenorhabditis elegans.
[So] Source:Dev Biol;430(1):80-89, 2017 10 01.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Reproductive plasticity is the ability of an animal to modulate its reproductive functions in response to environmental changes. For example, Caenorhabditis elegans, a free-living nematode, can adjust the onsets of oogenesis and embryogenesis under harsh environmental conditions, including starvation. However, the molecular mechanisms used to perceive and translate environmental signals into reproductive functional adjustments remain largely uncharacterized. We discovered that in C. elegans, the glutamate receptor homolog MGL-1 initiated reproductive plasticity in response to starvation. A genetic analysis of the mutant gene, mgl-1(tm1811), suggested that starvation delayed the onsets of oogenesis and embryogenesis via MGL-1. Cell-specific rescues of mgl-1 deletion mutants, which used transgenic lines designed to express MGL-1 in different neurons (e.g., RMD, AIA, AIY, and NSM), suggested that only AIY-rescued animals exhibited normal delays in oogenesis and embryogenesis equivalent to those of wild-type animals, suggesting recovery. Furthermore, in AIY neurons, MGL-1 appears to use neuropeptide signaling, rather than glutamate, to translate starvation stimuli into delayed oogenesis and embryogenesis. Our findings, which reveal molecular linkages between starvation signals and reproductive alterations, may provide a basis for understanding energy reallocation mechanisms, as the mgl-1 deletion mutant exhibited more severe reductions in lifespan and fat accumulation than did wild-type animals under starvation conditions. Taken together, MGL-1 is the molecular driver underlying the translation of starvation signals to reproduction plasticity in an AIY neuron-specific manner.
[Mh] Termos MeSH primário: Proteínas de Caenorhabditis elegans/metabolismo
Caenorhabditis elegans/citologia
Caenorhabditis elegans/metabolismo
Neurônios/metabolismo
Neuropeptídeos/metabolismo
Transdução de Sinais
Inanição/metabolismo
[Mh] Termos MeSH secundário: Animais
Caenorhabditis elegans/embriologia
Embrião não Mamífero/citologia
Embrião não Mamífero/metabolismo
Desenvolvimento Embrionário
Deleção de Genes
Glutamatos/metabolismo
Neurônios/citologia
Oogênese
Reprodução
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Caenorhabditis elegans Proteins); 0 (Flp-1 protein, C elegans); 0 (Glutamates); 0 (Neuropeptides)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE



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