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Pesquisa : C19.053.500.480 [Categoria DeCS]
Referências encontradas : 257 [refinar]
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[PMID]:28747362
[Au] Autor:Travers S; Martinerie L; Boileau P; Lombès M; Pussard E
[Ad] Endereço:Inserm, U1185, Le Kremlin-Bicêtre, France.
[Ti] Título:Alterations of adrenal steroidomic profiles in preterm infants at birth.
[So] Source:Arch Dis Child Fetal Neonatal Ed;103(2):F143-F151, 2018 Mar.
[Is] ISSN:1468-2052
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Preterm infants have relative adrenal and kidney immaturity. Recently, we linked their urine sodium loss to a hypoaldosteronism at variance with an appropriate stimulation of the renin-angiotensin system. To investigate this defective aldosterone secretion, we analyse the biosynthesis pathways of adrenal steroids in neonates according to gestational age (GA). DESIGN: Multicentre study (Premaldo) including 152 neonates classified into three groups: group 1 (very preterm (VPT)): <33 gestational weeks (GW); group 2 (preterm (PT)): 33-36 GW and group 3 (term (T)): ≥GW. METHOD: Steroidomic profiles of mineralocorticoids, glucocorticoids and adrenal androgens were established from umbilical cord at birth (n=152) and peripheral blood at day 3 (n=70) using a recently developed liquid chromatography mass spectrometry method (LC-MS/MS). The enzymatic activity of each biosynthesis step was estimated by the product-to-substrate ratio. RESULTS: At birth, VPT infants exhibit a global defect in adrenal steroid synthesis pathways leading to lower levels of aldosterone, cortisol and androstenedione than in term infants. This defect was strongly related to GA. On day 3, steroid precursors (progesterone, 11-deoxycorticosterone (DOC), 17-hydroxyprogesterone(17-OH-P) and 11-deoxycortisol (S)) were higher in VPT and negatively correlated with GA. Despite of precursors' accumulation, aldosterone and cortisol were similar in the three groups. At birth and day 3, a low cortisol/11-deoxycortisol ratio was found in preterm infants, suggesting an 11-beta-hydroxylase activity ( ) deficiency. CONCLUSIONS: At birth, VPT infants exhibit a global deficit in mineralocorticoids, glucocorticoids and adrenal androgens that attenuates on day 3 of life. Steroid profiling using LC-MS/MS provides evidence for a partial defect in 11-hydroxylase along with prematurity.
[Mh] Termos MeSH primário: Corticosteroides/metabolismo
Recém-Nascido Prematuro
[Mh] Termos MeSH secundário: Corticosteroides/sangue
Androgênios/metabolismo
Cromatografia Líquida
Sistema Enzimático do Citocromo P-450/metabolismo
Sangue Fetal/química
Idade Gestacional
Glucocorticoides/metabolismo
Seres Humanos
Hipoaldosteronismo/metabolismo
Lactente Extremamente Prematuro
Recém-Nascido
Mineralocorticoides/metabolismo
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Androgens); 0 (Glucocorticoids); 0 (Mineralocorticoids); 9035-51-2 (Cytochrome P-450 Enzyme System)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1136/archdischild-2016-312457


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[PMID]:28637561
[Au] Autor:Starker LF; Christakis I; Julien JS; Schwarz K; Graham P; Grubbs EG; Lee JE; Perrier ND
[Ti] Título:Considering Postoperative Functional Hypoaldosteronism after Unilateral Adrenalectomy.
[So] Source:Am Surg;83(6):598-604, 2017 Jun 01.
[Is] ISSN:1555-9823
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Conn's Syndrome is an uncommon condition. Patients who have undergone adrenalectomy in the early postoperative period can demonstrate biochemical hypoaldosteronism. Given the rare nature of this phenomenon we investigated its incidence and whether it translated to clinical findings. A single-institution retrospective review of all patients with biochemically proven hyperaldosteronism from 2005 to 2014 that underwent unilateral adrenalectomy. A total of 29 patients fit the inclusion criteria. Functional hypoaldosteronism had appreciated in 18/29 (62%) patients, whereas 11 patients (38%) had normal postoperative aldosterone. No significant differences between diagnostic groups were found in terms of clinical outcomes (length of stay, postoperative symptomatology, and readmissions P = 0.669, 0.154, and 0.268, respectively). Two (7%) patients required medical therapy. Biochemical evidence of functional hypoaldosteronism was identified in two-thirds of patients undergoing unilateral adrenalectomy. Although contralateral aldosterone suppression can be anticipated, the phenotypic response varied and the outcomes were similar to patients with normal aldosterone levels. Current guidelines make no formal recommendations for assessment of hypoaldosteronism after adrenalectomy, resulting in varying practice paradigms. Surgeons should consider the risk of postoperative hypoaldosteronism in these patients and counsel patients accordingly. Prospective investigations should be performed to assist in development of an outcomes-based care delivery model for these patients.
[Mh] Termos MeSH primário: Adrenalectomia/efeitos adversos
Aldosterona/sangue
Hiperaldosteronismo/cirurgia
Hipoaldosteronismo/diagnóstico
Hipoaldosteronismo/etiologia
[Mh] Termos MeSH secundário: Adrenalectomia/métodos
Adulto
Biomarcadores/sangue
Feminino
Seguimentos
Seres Humanos
Hipoaldosteronismo/sangue
Incidência
Masculino
Meia-Idade
Período Pós-Operatório
Valor Preditivo dos Testes
Estudos Retrospectivos
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 4964P6T9RB (Aldosterone)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE


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[PMID]:28090048
[Au] Autor:Hataya Y; Oba A; Yamashita T; Komatsu Y
[Ad] Endereço:Department of Endocrinology, Kyoto City Hospital, Japan.
[Ti] Título:Hyponatremia in an Elderly Patient due to Isolated Hypoaldosteronism Occurring after Licorice Withdrawal.
[So] Source:Intern Med;56(2):175-179, 2017.
[Is] ISSN:1349-7235
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Hyponatremia is one of the most common electrolyte disorders encountered in the elderly. We present the case of an 81-year-old man who developed hyponatremia due to isolated hypoaldosteronism occurring after licorice withdrawal. He had severe hypokalemia with hypertension and was diagnosed with pseudoaldosteronism. He had been taking a very small dose of licorice as a mouth refresher since his early adulthood. Five months after licorice withdrawal, he developed hypovolemic hyponatremia, which was resolved with administration of fludrocortisone acetate. Our experience with this case suggests that isolated hypoaldosteronism occurring after licorice withdrawal should be considered as a potential cause of hyponatremia in elderly patients.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas
Glycyrrhiza
Hipoaldosteronismo/diagnóstico
Hiponatremia/diagnóstico
Antissépticos Bucais
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Diagnóstico Diferencial
Fludrocortisona/análogos & derivados
Fludrocortisona/uso terapêutico
Seres Humanos
Hipoaldosteronismo/sangue
Hipoaldosteronismo/complicações
Hipoaldosteronismo/tratamento farmacológico
Hiponatremia/sangue
Hiponatremia/complicações
Hiponatremia/tratamento farmacológico
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Mouthwashes); U0476M545B (Fludrocortisone); V47IF0PVH4 (fludrocortisone acetate)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE
[do] DOI:10.2169/internalmedicine.56.6438


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[PMID]:27468039
[Au] Autor:Whoriskey ST; Bartlett SL; Baitchman E
[Ti] Título:HYPOALDOSTERONISM IN A MATSCHIE'S TREE KANGAROO (DENDROLAGUS MATSCHIEI).
[So] Source:J Zoo Wildl Med;47(2):628-31, 2016 Jun.
[Is] ISSN:1042-7260
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 20-yr-old female Matschie's tree kangaroo (Dendrolagus matschiei) was diagnosed with hypoaldosteronism, a rare condition in which the body fails to produce normal amounts of the mineralocorticoid aldosterone. Aldosterone plays a key role in body salt homeostasis, increasing sodium reabsorption and promoting excretion of potassium. Hypoaldosteronism resulted in decreased appetite, lethargy, and weight loss in conjunction with hyponatremia, hyperkalemia, and hypercalcemia in this tree kangaroo. The animal was successfully managed with mineralocorticoid replacement using desoxycorticosterone pivalate. To the authors' knowledge this is the first report of hypoaldosteronism in a tree kangaroo and one of the few reports in the veterinary literature in any species.
[Mh] Termos MeSH primário: Desoxicorticosterona/análogos & derivados
Hipoaldosteronismo/veterinária
Macropodidae
Mineralocorticoides/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Animais de Zoológico
Desoxicorticosterona/uso terapêutico
Feminino
Hipoaldosteronismo/diagnóstico
Hipoaldosteronismo/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mineralocorticoids); 16665T4A2X (deoxycortone pivalate); 40GP35YQ49 (Desoxycorticosterone)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160729
[Lr] Data última revisão:
160729
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160729
[St] Status:MEDLINE
[do] DOI:10.1638/2015-0193.1


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[PMID]:27125267
[Au] Autor:Üstyol A; Atabek ME; Taylor N; Yeung MC; Chan AO
[Ad] Endereço:Necmettin Erbakan University Faculty of Medicine, Department of Pediatric Endocrinology and Diabetes, Konya, Turkey, Phone: +90 332 223 63 50 E-mail: alaustyol@gmail.com.
[Ti] Título:Corticosterone Methyl Oxidase Deficiency Type 1 with Normokalemia in an Infant.
[So] Source:J Clin Res Pediatr Endocrinol;8(3):356-9, 2016 Sep 01.
[Is] ISSN:1308-5735
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Ab] Resumo:Isolated aldosterone synthase deficiency may result in life-threatening salt-wasting and failure to thrive. The condition involves hyperkalemia accompanying hyponatremia. Two types of aldosterone synthase deficiency may be observed depending on hormone levels: corticosterone methyl oxidase type 1 (CMO 1) and CMO 2. Herein, we describe a Turkish infant patient with aldosterone synthase deficiency who presented with failure to thrive and salt wasting but with normal potassium levels. Urinary steroid characteristics were compatible with CMO I deficiency. Diagnosis of aldosterone synthase deficiency was confirmed by mutational analysis of the CYP11B2 gene which identified the patient as homozygous for two mutations: c.788T>A (p.Ile263Asn) and c.1157T>C (p.Val386Ala). Family genetic study revealed that the mother was heterozygous for c.788T>A and homozygous for c.1157T>C and the father was heterozygous for both c.788T>A and c.1157T>C. To the best of our knowledge, this is only the second Turkish case with a confirmed molecular basis of type 1 aldosterone synthase deficiency. This case is also significant in showing that spot urinary steroid analysis can assist with the diagnosis and that hyperkalemia is not necessarily part of the disease.
[Mh] Termos MeSH primário: Citocromo P-450 CYP11B2/deficiência
Hipoaldosteronismo/genética
Mutação
Potássio/metabolismo
[Mh] Termos MeSH secundário: Corticosterona/urina
Citocromo P-450 CYP11B2/genética
Citocromo P-450 CYP11B2/urina
Análise Mutacional de DNA
Seres Humanos
Hipoaldosteronismo/urina
Lactente
Masculino
Potássio/sangue
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
EC 1.14.15.4 (Cytochrome P-450 CYP11B2); RWP5GA015D (Potassium); W980KJ009P (Corticosterone)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160430
[St] Status:MEDLINE
[do] DOI:10.4274/jcrpe.2824


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[PMID]:26989116
[Au] Autor:Jakes AD; Baynes K; Nelson-Piercy C
[Ad] Endereço:Hammersmith Hospital, London, UK.
[Ti] Título:Renal tubular acidosis type 4 in pregnancy.
[So] Source:BMJ Case Rep;2016, 2016 Mar 17.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We describe the clinical course of renal tubular acidosis (RTA) type 4 in pregnancy, which has not been previously published. Renal tubular acidosis type 4 is a condition associated with increased urinary ammonia secondary to hypoaldosteronism or pseudohypoaldosteronism. Pregnancy may worsen the hyperkalaemia and acidosis of renal tubular acidosis type 4, possibly through an antialdosterone effect. We advise regular monitoring of potassium and pH throughout pregnancy to ensure safe levels are maintained.
[Mh] Termos MeSH primário: Aldosterona/metabolismo
Hipoaldosteronismo/complicações
Nefropatias/complicações
Potássio/sangue
Complicações na Gravidez/metabolismo
[Mh] Termos MeSH secundário: Equilíbrio Ácido-Base
Acidose Tubular Renal/complicações
Adulto
Amônia/urina
Feminino
Seres Humanos
Concentração de Íons de Hidrogênio
Hiperpotassemia/complicações
Nefropatias/metabolismo
Túbulos Renais/metabolismo
Gravidez
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
4964P6T9RB (Aldosterone); 7664-41-7 (Ammonia); RWP5GA015D (Potassium)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160319
[St] Status:MEDLINE


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[PMID]:26730868
[Au] Autor:Block BL; Bernard S; Schwartzstein RM
[Ad] Endereço:1 Department of Medicine, New York Presbyterian Hospital, Columbia University Medical Center, New York, New York; and.
[Ti] Título:Hypo-Hypo: A Complex Metabolic Disorder.
[So] Source:Ann Am Thorac Soc;13(1):127-33, 2016 Jan.
[Is] ISSN:2325-6621
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Acidose Tubular Renal
Enterocolite Pseudomembranosa
Fludrocortisona/administração & dosagem
Hipoaldosteronismo
Rim
[Mh] Termos MeSH secundário: Equilíbrio Ácido-Base
Acidose Tubular Renal/sangue
Acidose Tubular Renal/etiologia
Acidose Tubular Renal/fisiopatologia
Acidose Tubular Renal/terapia
Adulto
Antibacterianos/administração & dosagem
Clostridium difficile/isolamento & purificação
Diarreia/complicações
Enterocolite Pseudomembranosa/complicações
Enterocolite Pseudomembranosa/diagnóstico
Enterocolite Pseudomembranosa/tratamento farmacológico
Enterocolite Pseudomembranosa/fisiopatologia
Seres Humanos
Hiperpotassemia/etiologia
Hipoaldosteronismo/sangue
Hipoaldosteronismo/complicações
Hipoaldosteronismo/diagnóstico
Hipoaldosteronismo/fisiopatologia
Hipoaldosteronismo/terapia
Rim/metabolismo
Rim/fisiopatologia
Masculino
Mineralocorticoides/administração & dosagem
Resultado do Tratamento
Vancomicina/administração & dosagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Mineralocorticoids); 6Q205EH1VU (Vancomycin); U0476M545B (Fludrocortisone)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160106
[St] Status:MEDLINE
[do] DOI:10.1513/AnnalsATS.201507-449CC


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[PMID]:26433138
[Au] Autor:Uçar A; Aydemir Y; Dogan A; Tunçez E
[Ad] Endereço:Department of Pediatric Endocrinology and Diabetes, Sisli Etfal Training and Research Hospital, Istanbul, Turkey.
[Ti] Título:Relative hypoaldosteronism in a patient with Wolcott-Rallison syndrome.
[So] Source:Diabet Med;33(3):e13-6, 2016 Mar.
[Is] ISSN:1464-5491
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Wolcott-Rallison syndrome is an autosomal recessive, multisystem disorder with onset of diabetes in the neonatal period or early infancy. CASE REPORT: A 9-year-old girl with diabetes and growth failure from 2 months of age presented with ketoacidosis and multiple organ failure. Evaluation for short stature revealed epiphyseal dysplasia. A homozygous mutation in the EIF2AK3 gene confirmed the clinical diagnosis of Wolcott-Rallison syndrome. She was euthyroid. Biochemical evaluation for potential adrenal dysfunction because of persistently elevated serum potassium (range 5.9-6.3 meq/l) and low serum sodium levels (range 128-130 meq/l) 2 weeks after resolution of ketoacidosis yielded normal findings with respect to basal corticotropin (31 pg/ml) and cortisol (18.7 µg/dl) levels. Estimated GFR-Schwartz (36.9 ml/min/1.73 m(2) ) was consistent with stage 3 chronic renal failure. The transtubular potassium gradient was 1.39 (normal value in hyperkalemic states: > 4.1). The plasma aldosterone (upright: 241.3 pmol/l) was within normal ranges, and plasma renin [39 pg/ml (range 5.41-34.53 pg/ml)] was slightly elevated. The patient was diagnosed as having relative hypoaldosteronism and was started on a sodium-rich diet and low potassium. Failure to respond to the dietary intervention prompted a trial of oral fludrocortisone with subsequent normalization of electrolyte levels. CONCLUSIONS: This is the first case report of Wolcott-Rallison syndrome complicated with relative hypoaldosteronism. Further research is needed to probe the causal inference of relative hypoaldosteronism with chronic renal failure in patients with Wolcott-Rallison syndrome.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 1/complicações
Epífises/anormalidades
Hipoaldosteronismo/etiologia
Osteocondrodisplasias/complicações
[Mh] Termos MeSH secundário: Criança
Diabetes Mellitus Tipo 1/diagnóstico por imagem
Diabetes Mellitus Tipo 1/tratamento farmacológico
Cetoacidose Diabética/complicações
Cetoacidose Diabética/diagnóstico por imagem
Epífises/diagnóstico por imagem
Feminino
Fludrocortisona/uso terapêutico
Seres Humanos
Hipoaldosteronismo/diagnóstico por imagem
Hipoaldosteronismo/tratamento farmacológico
Insuficiência de Múltiplos Órgãos/complicações
Insuficiência de Múltiplos Órgãos/diagnóstico por imagem
Osteocondrodisplasias/diagnóstico por imagem
Osteocondrodisplasias/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
U0476M545B (Fludrocortisone)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151004
[St] Status:MEDLINE
[do] DOI:10.1111/dme.12968


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[PMID]:26345674
[Au] Autor:Sánchez-Marcos C; Hoffman V; Prieto-González S; Hernández-Rodríguez J; Espinosa G
[Ad] Endereço:Department of Autoimmune Diseases, Hospital Clínic, Barcelona, Catalonia, Spain.
[Ti] Título:Renal tubular acidosis type IV as a complication of lupus nephritis.
[So] Source:Lupus;25(3):307-9, 2016 Mar.
[Is] ISSN:1477-0962
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Renal tubular acidosis (RTA) is a rare complication of renal involvement of systemic lupus erythematosus (SLE). We describe a 24-year-old male with type IV lupus nephropathy as a presenting manifestation of SLE. He presented with improvement of renal function following induction therapy with three pulses of methylprednisolone and 500 mg biweekly pulses of cyclophosphamide. However, a week after the first pulse of cyclophosphamide, the patient presented with a significant increase in legs edema and severe hyperkalemia. Type IV RTA associated with hyporeninemic hypoaldosteronism was suspected in the presence of metabolic acidosis with a normal anion gap, severe hyperkalemia without worsening renal function, and urinary pH of 5. RTA was confirmed with a transtubular potassium concentration gradient of 2 and low levels of plasma aldosterone, renin, angiotensin II, and cortisol. Intravenous bicarbonate, high-dose furosemide, and fludrocortisone were administered with normalization of potassium levels and renal function.
[Mh] Termos MeSH primário: Hipoaldosteronismo/etiologia
Lúpus Eritematoso Sistêmico/complicações
Nefrite Lúpica/etiologia
[Mh] Termos MeSH secundário: Acidose/etiologia
Anti-Inflamatórios/administração & dosagem
Bicarbonatos/administração & dosagem
Quimioterapia Combinada
Edema/etiologia
Glucocorticoides/administração & dosagem
Seres Humanos
Hiperpotassemia/etiologia
Hipoaldosteronismo/diagnóstico
Hipoaldosteronismo/tratamento farmacológico
Imunossupressores/administração & dosagem
Lúpus Eritematoso Sistêmico/diagnóstico
Lúpus Eritematoso Sistêmico/tratamento farmacológico
Nefrite Lúpica/diagnóstico
Nefrite Lúpica/tratamento farmacológico
Masculino
Pulsoterapia
Inibidores de Simportadores de Cloreto de Sódio e Potássio/administração & dosagem
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Bicarbonates); 0 (Glucocorticoids); 0 (Immunosuppressive Agents); 0 (Sodium Potassium Chloride Symporter Inhibitors)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150909
[St] Status:MEDLINE
[do] DOI:10.1177/0961203315603143


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[PMID]:26121445
[Au] Autor:Wilczynski C; Shah L; Emanuele MA; Emanuele N; Mazhari A
[Ti] Título:SELECTIVE HYPOALDOSTERONISM: A REVIEW.
[So] Source:Endocr Pract;21(8):957-65, 2015 Aug.
[Is] ISSN:1530-891X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Selective hypoaldosteronism (SH) is a condition manifested by hyperkalemia due to low aldosterone secretion with normal cortisol. One of the obstacles in diagnosis is the awareness of the condition itself. The objective of this review is to highlight what is known about the epidemiology, pathophysiology, etiology, presentation, diagnosis, and treatment of SH. METHODS: Literature search was performed on PubMed and Ovid Medline for articles which contained hypoaldosteronism as a major topic. RESULTS: The recent literature on this topic is surprisingly limited. Few recent review articles were found, none of which were in English and less than 5 years old. Case reports and genetic literature were also included in this review, as they contain the most recent reports of SH in the literature. CONCLUSION: Awareness about SH will hopefully help physicians to identify patients at risk as well as decide on treatment if any therapy is required.
[Mh] Termos MeSH primário: Hipoaldosteronismo
[Mh] Termos MeSH secundário: Seres Humanos
Hipoaldosteronismo/diagnóstico
Hipoaldosteronismo/epidemiologia
Hipoaldosteronismo/etiologia
Hipoaldosteronismo/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1607
[Cu] Atualização por classe:150807
[Lr] Data última revisão:
150807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150630
[St] Status:MEDLINE
[do] DOI:10.4158/EP14551.RA



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