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[PMID]:29489687
[Au] Autor:Li L; Yang H; Li J; Yu Y; Wang F; Zhu X; Liu G
[Ad] Endereço:Department of Neurology, PLA 44 Hospital.
[Ti] Título:Misdiagnosis of idiopathic hypoparathyroidism: A case report and literature review.
[So] Source:Medicine (Baltimore);97(9):e9884, 2018 Mar.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Idiopathic hypoparathyroidism (IHP) is a rare endocrine condition, which is frequently represented by neuropsychiatric disorders. Hence, the misdiagnosis rate of the disease is rather high, especially for neurologists. PATIENT CONCERNS: We reported a case of misdiagnosed, atypical IHP. In addition, the literature on IHP and the misdiagnosis published in China in the past 2 decades has been reviewed and summarized. DIAGNOSES: Blood testing confirmed that parathyroid hormone (PTH) = 0 pg/mL and the final diagnosis was IHP. INTERVENTIONS AND OUTCOMES: With calcium and vitamin D supplementation, the patient's myasthenia improved significantly, and muscle enzymes returned to normal gradually. One-year follow-up demonstrated that the patient's myasthenia disappeared, and the blood calcium and PTH levels were normal. In addition, the literature on IHP and the misdiagnosis published in China in the past 2 decades has been reviewed and summarized. LESSONS: The misdiagnosis rate of IHP in China was high in the past 2 decades, which might be attributed to the misdiagnosis as epilepsy or mental diseases. A clinician should be able to understand the disease and emphasize the screening of high-risk population, especially for those patients with hypocalcemia, hyperphosphatemia, and increased blood creatine kinase with unknown causes or nontypical clinical symptoms.
[Mh] Termos MeSH primário: Erros de Diagnóstico/efeitos adversos
Hipoparatireoidismo/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Hipoparatireoidismo/tratamento farmacológico
Hormônio Paratireóideo/sangue
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Parathyroid Hormone)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180301
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009884


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[PMID]:29262450
[Au] Autor:Lin PL; Liang FY; Han P; Chen RH; Yu ST; Cai Q; Huang XM
[Ad] Endereço:Department of Otorhinolaryngology Head and Neck Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510289, China.
[Ti] Título:[Gasless endoscopic selective lateral neck dissection via an anterior chest approach for papillary thyroid carcinomas].
[So] Source:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;52(12):915-920, 2017 Dec 07.
[Is] ISSN:1673-0860
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To assess the safety and curative effect of gasless endoscopic selective lateral neck dissection (GESLND) via an anterior chest approach for papillary thyroid carcinoma (PTC). Eighteen patients with PTC(T1-2N1bM0, size<3.0 cm), having GESLND via an anterior chest approach, were included from November 2008 to December 2016. GESLND via an anterior chest approach was successfully performed in all 18 PTC patients (seven male and eleven female) with 83.3% of T1 and 16.7% of T2. The mean operative time of selective lateral neck dissection was 73 min (range 51-92 min). The mean of intraoperative bleeding was 61.1 ml (range 30-120 ml). No major complications occurred except one transient hypoparathyroidism. No residual thyroid glands were detected on ultrasonography and thyroglobulin was(0.73±0.16)ng/ml three months postoperatively. The median of follow-up was 54.5 months (range 6-104 months). No recurrence disease was observed in any patient on ultrasonography, computer tomography, thyroglobulin or selective iodine-131 scan during the follow-up period. The cosmetic result and functional preservation was excellent, when the assessments were performed three months postoperatively. GESLND via an anterior chest approach is feasible and safe for selected PTCs, with superior appearance.
[Mh] Termos MeSH primário: Carcinoma Papilar/cirurgia
Endoscopia/métodos
Esvaziamento Cervical/métodos
Neoplasias da Glândula Tireoide/cirurgia
[Mh] Termos MeSH secundário: Perda Sanguínea Cirúrgica/estatística & dados numéricos
Carcinoma Papilar/patologia
Endoscopia/efeitos adversos
Feminino
Seres Humanos
Hipoparatireoidismo/etiologia
Radioisótopos do Iodo
Masculino
Duração da Cirurgia
Parede Torácica/cirurgia
Tireoglobulina/sangue
Neoplasias da Glândula Tireoide/patologia
Tomografia Computadorizada por Raios X
Ultrassonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iodine Radioisotopes); 0 (Iodine-131); 9010-34-8 (Thyroglobulin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1673-0860.2017.12.008


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[PMID]:29066572
[Au] Autor:Villarroya-Marquina I; Sancho J; Lorente-Poch L; Gallego-Otaegui L; Sitges-Serra A
[Ad] Endereço:Endocrine Surgery UnitHospital del Mar, Departament de Cirurgia, Universitat Autònoma de Barcelona, Barcelona, Spain.
[Ti] Título:Time to parathyroid function recovery in patients with protracted hypoparathyroidism after total thyroidectomy.
[So] Source:Eur J Endocrinol;178(1):105-113, 2018 Jan.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Hypocalcaemia is the most common adverse effect after total thyroidectomy. It recovers in about two-thirds of the patients within the first postoperative month. Little is known, however, about recovery of the parathyroid function (RPF) after this time period. The aim of the present study was to investigate the time to RPF in patients with protracted (>1 month) hypoparathyroidism after total thyroidectomy. DESIGN: Cohort prospective observational study. METHODS: Adult patients undergoing total thyroidectomy for goitre or thyroid cancer. Cases with protracted hypoparathyroidism were studied for RPF during the following months. Time to RPF and variables associated with RPF or permanent hypoparathyroidism were recorded. RESULTS: Out of 854 patients undergoing total thyroidectomy, 142 developed protracted hypoparathyroidism. Of these, 36 (4.2% of the entire cohort) developed permanent hypoparathyroidism and 106 recovered: 73 before 6 months, 21 within 6-12 months and 12 after 1 year follow-up. Variables significantly associated with RPF were the number of parathyroid glands remaining (not autografted nor inadvertently resected) and a serum calcium concentration >2.25 mmol/L at one postoperative month. Late RPF (>6 months) was associated with surgery for thyroid cancer. RPF was still possible after one year in patients with four parathyroid glands preserved and serum calcium concentration at one month >2.25 mmol/L. CONCLUSIONS: Permanent hypoparathyroidism should not be diagnosed in patients requiring replacement therapy for more than six months, especially if the four parathyroid glands were preserved.
[Mh] Termos MeSH primário: Hipoparatireoidismo/etiologia
Hipoparatireoidismo/fisiopatologia
Glândulas Paratireoides/fisiopatologia
Complicações Pós-Operatórias/fisiopatologia
Tireoidectomia/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Cálcio/sangue
Estudos de Coortes
Feminino
Seguimentos
Bócio/cirurgia
Seres Humanos
Masculino
Meia-Idade
Hormônio Paratireóideo/sangue
Período Pós-Operatório
Estudos Prospectivos
Recuperação de Função Fisiológica
Neoplasias da Glândula Tireoide/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Parathyroid Hormone); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171129
[Lr] Data última revisão:
171129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0589


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[PMID]:29073906
[Au] Autor:Yang A; Kim J; Ki CS; Hong SH; Cho SY; Jin DK
[Ad] Endereço:Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea.
[Ti] Título:HDR syndrome with a novel mutation in GATA3 mimicking a congenital X-linked stapes gusher: a case report.
[So] Source:BMC Med Genet;18(1):121, 2017 Oct 26.
[Is] ISSN:1471-2350
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hypoparathyroidism, sensorineural hearing loss, and renal disease (HDR) syndrome, also known as Barakat syndrome, is a rare genetic disorder with high phenotypic heterogeneity caused by haploinsufficiency of the GATA3 gene on chromosome 10p14-p15. For these reasons, the diagnosis of HDR syndrome is challenging and requires a high index of suspicion as well as genetic analysis. CASE PRESENTATION: A 14-month-old boy, with sensorineural hearing loss in both ears, showed typical radiological features of X-linked stapes gusher on preoperative temporal bone computed tomography (CT) for cochlear implantations. Then after his discharge from hospital, he suffered a hypocalcemic seizure and we discovered a renal cyst during investigation of hypocalcemia. He was finally diagnosed with HDR syndrome by clinical findings, which were confirmed by molecular genetic testing. Direct sequencing of the GATA3 gene showed a heterozygous 2-bp deletion (c.1201_1202delAT), which is predicted to cause a frameshift of the reading frame (p.Met401Valfs*106). CONCLUSIONS: To our knowledge, this is the first case of HDR syndrome with a novel de novo variant mimicking a congenital X-linked stapes gusher syndrome. Novel mutations and the diversity of clinical manifestations expand the genotypic and phenotypic spectrum of HDR syndrome. Diagnosis of HDR syndrome is still challenging, but clinicians should consider it in their differential diagnosis for children with a wide range of clinical manifestations including hypocalcemia induced seizures and deafness. We hope that this case will contribute to further understanding and studies of HDR-associated GATA3 mutations.
[Mh] Termos MeSH primário: Cromossomos Humanos Par 10/química
Implante Coclear
Mutação da Fase de Leitura
Fator de Transcrição GATA3/genética
Perda Auditiva Neurossensorial/diagnóstico
Hipoparatireoidismo/diagnóstico
Nefrose/diagnóstico
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Expressão Gênica
Doenças Genéticas Ligadas ao Cromossomo X/diagnóstico
Doenças Genéticas Ligadas ao Cromossomo X/genética
Doenças Genéticas Ligadas ao Cromossomo X/fisiopatologia
Haploinsuficiência
Perda Auditiva Condutiva/diagnóstico
Perda Auditiva Condutiva/genética
Perda Auditiva Condutiva/fisiopatologia
Perda Auditiva Neurossensorial/genética
Perda Auditiva Neurossensorial/fisiopatologia
Perda Auditiva Neurossensorial/cirurgia
Heterozigoto
Seres Humanos
Hipoparatireoidismo/genética
Hipoparatireoidismo/fisiopatologia
Hipoparatireoidismo/cirurgia
Lactente
Masculino
Nefrose/genética
Nefrose/fisiopatologia
Nefrose/cirurgia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (GATA3 Transcription Factor); 0 (GATA3 protein, human)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171028
[St] Status:MEDLINE
[do] DOI:10.1186/s12881-017-0484-6


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[PMID]:29068988
[Au] Autor:Chen KC; Iqbal U; Nguyen PA; Hsu CH; Huang CL; Hsu YE; Atique S; Islam MM; Li YJ; Jian WS
[Ad] Endereço:aGraduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan bInternational Center for Health Information Technology (ICHIT), Taipei Medical University, Taipei, Taiwan cDepartment of Dermatology, Wan Fang Hospital, Taipei, Taiwan dDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan eSchool of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan fSchool of Health Care Administration, Taipei Medical University, Taipei, Taiwan gFaculty of Health Sciences, Macau University of Science and Technology, Macau, China hMaster Program in Global Health and Development, College of Public Health, Taipei Medical University, Taipei, Taiwan.
[Ti] Título:The impact of different surgical procedures on hypoparathyroidism after thyroidectomy: A population-based study.
[So] Source:Medicine (Baltimore);96(43):e8245, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The main objective of this study is to investigate the outcome between surgical procedures and the risk of development of hypoparathyroidism followed by surgical procedure in patients with thyroid disorders.We analyzed the data acquired from Taiwan's Bureau of National Health Insurance (BNHI) research database from 1998 to 2011 and found 9316 patients with thyroid surgery. Cox regression model was used to calculate the hazard ratio (HR).A count of 314 cases (3.4%) of hypoparathyroidism was identified. The 9 years cumulated incidence of hypoparathyroidism was the highest in patient undergone bilateral total thyroidectomy (13.5%) and the lowest in the patient with unilateral subtotal thyroidectomy (1.2%). However, in the patients who had undergone unilateral subtotal, the risk was the highest in bilateral total (HR: 11.86), followed by radical thyroidectomy with unilateral neck lymph node dissection (HR: 8.56), unilateral total (HR, 4.39), and one side total and another side subtotal (HR: 2.80).The extent of thyroid resection determined the risk of development of hypoparathyroidism. It is suggested that the association of these factors is investigated in future studies.
[Mh] Termos MeSH primário: Hipoparatireoidismo/epidemiologia
Hipoparatireoidismo/etiologia
Complicações Pós-Operatórias
Tireoidectomia/efeitos adversos
Tireoidectomia/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Incidência
Excisão de Linfonodo/efeitos adversos
Fatores de Risco
Taiwan/epidemiologia
Doenças da Glândula Tireoide/cirurgia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008245


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[PMID]:28953673
[Au] Autor:Zheng J; Song H; Cai S; Wang Y; Han X; Wu H; Gao Z; Qiu F
[Ad] Endereço:Department of General Surgery, Beijing Chaoyang Hospital Affiliated Capital Medical University, Beijing, China.
[Ti] Título:Evaluation of clinical significance and risk factors of incidental parathyroidectomy due to thyroidectomy: A single-center retrospective clinical study.
[So] Source:Medicine (Baltimore);96(39):e8175, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We assessed the clinical significance and risk factors of incidental parathyroidectomy during total thyroidectomy with or without central neck dissection or subtotal thyroidectomy.Retrospective analysis of clinical and pathological features of 548 consecutive thyroidectomy cases was compared by grouping into inadvertent resection (IR, n = 86) with IR of parathyroid glands, non-IR (n = 462) without, and then into postoperative hypoparathyroidism (PH, n = 140) with PH and non-PH (n = 408) without.Two hundred ninety-eight patients had total thyroidectomy and 250 had subtotal thyroidectomy. IR had higher malignant disease (P < .001), total thyroidectomy (P = .016), T3 and T4 classification (P = .005), central neck dissection (P < .001), recurrent laryngeal nerve palsy (P = .003), postoperative transient hypoparathyroidism (P < .001), duration of disease prior to thyroidectomy (P < .001), and weight of excised thyroid tissue (P < .001) than non-IR.Preoperative diagnosis of malignant disease, duration of disease prior to thyroidectomy, and central neck dissection were independent risk factors for incidental parathyroidectomy. Preoperative diagnosis of malignant disease, central neck dissection, duration of disease prior to thyroidectomy, weight of excised thyroid tissue, and incidental parathyroidectomy were correlated with PH.
[Mh] Termos MeSH primário: Hipoparatireoidismo
Erros Médicos
Esvaziamento Cervical
[Mh] Termos MeSH secundário: Idoso
China/epidemiologia
Feminino
Seres Humanos
Hipoparatireoidismo/epidemiologia
Hipoparatireoidismo/etiologia
Doença Iatrogênica/epidemiologia
Masculino
Erros Médicos/efeitos adversos
Erros Médicos/estatística & dados numéricos
Meia-Idade
Esvaziamento Cervical/efeitos adversos
Esvaziamento Cervical/métodos
Paratireoidectomia/estatística & dados numéricos
Estudos Retrospectivos
Fatores de Risco
Glândula Tireoide/patologia
Glândula Tireoide/cirurgia
Neoplasias da Glândula Tireoide/patologia
Neoplasias da Glândula Tireoide/cirurgia
Tireoidectomia/efeitos adversos
Tireoidectomia/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008175


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[PMID]:28953664
[Au] Autor:Su A; Wang B; Gong Y; Gong R; Li Z; Zhu J
[Ad] Endereço:Department of Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
[Ti] Título:Risk factors of hypoparathyroidism following total thyroidectomy with central lymph node dissection.
[So] Source:Medicine (Baltimore);96(39):e8162, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The risk factors of hypoparathyroidism after total thyroidectomy (TT) with central lymph node dissection (CND) have not been completely defined. The aim of the study was to evaluate the risk factors of hypoparathyroidism after the surgery.We retrospectively reviewed our patients who underwent TT and CND (including lateral lymph node dissection) for thyroid carcinoma between January 2013 and June 2016. According to the postoperative serum levels of parathyroid hormone within 6 months, the patients were divided into normal, transient hypoparathyroidism, and permanent hypoparathyroidism groups. The clinicopathologic characteristics and surgical details were compared among the 3 groups. The risk factors of hypoparathyroidism were investigated by univariate and multivariate analyses.Of the 903 patients, 399 (44.2%) were found to have transient hypoparathyroidism and 10 (1.1%) had permanent hypoparathyroidism. On multivariate analysis, female gender (P < .001), nonuse of carbon nanoparticles (P = .038), parathyroid autotransplantation (P < .001), accidental parathyroid resection (P = .004), and bilateral CND (BCND, P = .003) were the independent risk factors of transient hypoparathyroidism; nonuse of carbon nanoparticles (P = .041) and a tumor in the upper pole of thyroid gland (P = .031) were the independent risk factors of permanent hypoparathyroidism. Patients with transient hypoparathyroidism were more likely to develop permanent hypoparathyroidism when they had hypertension (P = .026) and a tumor in the upper pole of thyroid gland (P = .010).Precise surgical techniques and carbon nanoparticles suspension should be applied for in situ preservation of parathyroid glands (PGs) in thyroid carcinoma patients, especially in females with hypertension and a tumor in the upper pole of thyroid gland. Autotransplantation is only performed when a PG is resected inadvertently or devascularized. TT with BCND should be better performed by an experienced surgeon to reduce the incidence of hypoparathyroidism.
[Mh] Termos MeSH primário: Hipoparatireoidismo
Esvaziamento Cervical
Preservação de Órgãos/métodos
Glândulas Paratireoides
Reimplante/métodos
Neoplasias da Glândula Tireoide
Tireoidectomia
[Mh] Termos MeSH secundário: Adulto
China/epidemiologia
Feminino
Seres Humanos
Hipoparatireoidismo/diagnóstico
Hipoparatireoidismo/etiologia
Hipoparatireoidismo/cirurgia
Linfonodos/patologia
Linfonodos/cirurgia
Masculino
Meia-Idade
Esvaziamento Cervical/efeitos adversos
Esvaziamento Cervical/métodos
Glândulas Paratireoides/diagnóstico por imagem
Glândulas Paratireoides/cirurgia
Hormônio Paratireóideo/sangue
Complicações Pós-Operatórias/diagnóstico
Complicações Pós-Operatórias/cirurgia
Estudos Retrospectivos
Risco Ajustado
Fatores de Risco
Neoplasias da Glândula Tireoide/epidemiologia
Neoplasias da Glândula Tireoide/patologia
Neoplasias da Glândula Tireoide/cirurgia
Tireoidectomia/efeitos adversos
Tireoidectomia/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Parathyroid Hormone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008162


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[PMID]:28782797
[Au] Autor:Wang JB; Wu K; Shi LH; Sun YY; Li FB; Xie L
[Ad] Endereço:Department of Head and Neck Surgery, Institute of Micro-Invasive Surgery of Zhejiang University, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
[Ti] Título:In situ preservation of the inferior parathyroid gland during central neck dissection for papillary thyroid carcinoma.
[So] Source:Br J Surg;104(11):1514-1522, 2017 Oct.
[Is] ISSN:1365-2168
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Postoperative hypocalcaemia due to dysfunction of the parathyroid glands is the most common complication after total thyroidectomy plus central neck dissection (CND). There is a lack of surgical techniques described to help preserve the inferior parathyroid gland in situ during CND. The objective of this study was to introduce the 'TBP layer' (layer of thymus-blood vessel-inferior parathyroid gland) concept for preserving the inferior parathyroid gland in situ during CND, and to evaluate its effectiveness. METHODS: The study group included patients with primary papillary thyroid cancer who underwent total thyroidectomy with CND using the new surgical concept between January and December 2014. The control group included sex- and age-matched patients who underwent conventional total thyroidectomy with CND between January 2012 and December 2013. The proportion of inferior parathyroid glands preserved in situ and postoperative hypoparathyroidism rates in the two groups were compared. RESULTS: There were 181 patients in the study group and 306 in the control group. There were no significant differences between the groups in tumour size, multifocality, extrathyroidal extension, and number of harvested and metastatic central lymph nodes. The rate of inferior parathyroid gland preservation in situ was significantly improved from 37·9 to 76·3 per cent on the left side (P < 0·001), and from 52·0 to 77·9 per cent on the right side (P < 0·001), in the study group compared with the control group. The incidence of transient hypoparathyroidism decreased significantly from 35·0 to 7·2 per cent (P < 0·001). CONCLUSION: Applying the proposed surgical concept improved the rate of inferior parathyroid gland preservation in situ and decreased the incidence of transient postoperative hypoparathyroidism.
[Mh] Termos MeSH primário: Carcinoma/cirurgia
Esvaziamento Cervical
Tratamentos com Preservação do Órgão
Glândulas Paratireoides
Neoplasias da Glândula Tireoide/cirurgia
Tireoidectomia
[Mh] Termos MeSH secundário: Adulto
Carcinoma Papilar
Estudos de Casos e Controles
Feminino
Seres Humanos
Hipoparatireoidismo/etiologia
Masculino
Órgãos em Risco
Complicações Pós-Operatórias/etiologia
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170808
[St] Status:MEDLINE
[do] DOI:10.1002/bjs.10581


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[PMID]:28566604
[Au] Autor:Kamezaki M; Kusaba T; Adachi T; Yamashita N; Nakata M; Ota N; Shiotsu Y; Ishida M; Usui T; Tamagaki K
[Ad] Endereço:Division of Nephrology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
[Ti] Título:Unusual Proliferative Glomerulonephritis in a Patient Diagnosed to Have Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia (HDR) Syndrome with a Novel Mutation in the GATA3 Gene.
[So] Source:Intern Med;56(11):1393-1397, 2017.
[Is] ISSN:1349-7235
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Hypoparathyroidism, sensorineural deafness, and renal dysplasia (HDR) syndrome is a rare autosomal dominant disease caused by GATA3 mutations. Although several cases with variable renal features have been reported, the presence of histological changes within the glomeruli in adult patients is unclear. We herein report an adult case of HDR syndrome with a novel p.C288W (TGC>TGG) missense mutation in GATA3. His renal histology showed a membranoproliferative glomerulonephritis-like glomerular lesion. Additional renal histological analyses of HDR syndrome patients will be needed to clarify the role of GATA3 in both the developing and adult kidney.
[Mh] Termos MeSH primário: Glomerulonefrite/etiologia
Perda Auditiva Neurossensorial/complicações
Perda Auditiva Neurossensorial/genética
Hipoparatireoidismo/complicações
Hipoparatireoidismo/genética
Nefrose/complicações
Nefrose/genética
[Mh] Termos MeSH secundário: Fator de Transcrição GATA3
Seres Humanos
Masculino
Meia-Idade
Mutação de Sentido Incorreto
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (GATA3 Transcription Factor); 0 (GATA3 protein, human)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.2169/internalmedicine.56.7930


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[PMID]:28483283
[Au] Autor:Wémeau F; Wémeau JL
[Ad] Endereço:Centre hospitalier de Calais, 765, domaine de la Vigne, 59910 Bondues, France.
[Ti] Título:[The mouth of patients with hypo- and pseudohypoparathyroidism].
[Ti] Título:La bouche des hypoparathyroïdies et pseudohypoparathyroïdies..
[So] Source:Presse Med;46(9):838-844, 2017 Sep.
[Is] ISSN:2213-0276
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:Chronic calcipenia related to hypo- and pseudohypoparathyroidism favors trophic complications, especially expressed on the buccal cavity. Correlated with early onset of the disease and imperfect correction of the metabolic disorders, retardation to appearance and implantation of teeth are observed. The buccal signs often are the most immediately visible expression of the disease. They are painful and disabling. Other acute expressions reflect the neuromuscular hyperexcitability related to tetany. Finally, some etiologies determine specific damage, as in Di George's, HDR syndromes or in Albright's osteodystrophia.
[Mh] Termos MeSH primário: Hipoparatireoidismo/diagnóstico
Doenças da Boca/diagnóstico
Pseudo-Hipoparatireoidismo/diagnóstico
Odontopatias/diagnóstico
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Seres Humanos
Hipocalcemia/complicações
Hipocalcemia/diagnóstico
Hipoparatireoidismo/complicações
Pseudo-Hipoparatireoidismo/complicações
Estatística como Assunto
Tetania/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170510
[St] Status:MEDLINE



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