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[PMID]:29446579
[Au] Autor:Savchenkov MF; Efimova NV; Manueva RS; Nikolaeva LA; Shin NS
[Ti] Título:[Thyroid gland pathology in children population exposed to the combination of iodine deficiency and fluoride pollution of environment].
[So] Source:Gig Sanit;95(12):1201-5, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The article presents results of study of the impact of iodine deficiency and technogenic fluoride on the state of the thyroid gland in children. On the example of two districts of the city of Bratsk there were executed dynamic investigations (2002 and 2012), including the estimation of the pollution of ambient air and soil by fluorine compounds, levels of iodine intake by the body, the clinical examination of children aged from 5 to 7 years d and interviewing of their parents. In the course of the medical examination there were executed: physical examination by the pediatrician, endocrinologist, ultrasound examination of the thyroid gland, the determination both of serum hormone content by radioimmunoassay and urinary excretion offluorine and iodine. Concentrations of hydrogen fluoride and a solidfluorides in ambient air led to the accumulation offluoride ion in the soil. The iodine entering with drinking water and food, was established to provide only 37.5-50% of the daily requirement of iodine. Increased fluoride ion content in urine and milk teeth in children is associated with the concentrations of the fluorine-containing pollutants in the ambient air and soil. The fluoride pollution against the background of the natural iodine deficiency was established to increase the frequency of functional and morphological disorders of the thyroid gland in children.
[Mh] Termos MeSH primário: Poluição Ambiental
Iodo
Doenças da Glândula Tireoide
[Mh] Termos MeSH secundário: Criança
Monitoramento Ambiental/métodos
Poluição Ambiental/efeitos adversos
Poluição Ambiental/análise
Poluição Ambiental/prevenção & controle
Poluição Ambiental/estatística & dados numéricos
Feminino
Compostos de Flúor/efeitos adversos
Compostos de Flúor/análise
Disparidades nos Níveis de Saúde
Seres Humanos
Iodo/análise
Iodo/deficiência
Masculino
Saúde Pública/métodos
Saúde Pública/estatística & dados numéricos
Sibéria/epidemiologia
Doenças da Glândula Tireoide/diagnóstico
Doenças da Glândula Tireoide/epidemiologia
Doenças da Glândula Tireoide/etiologia
Doenças da Glândula Tireoide/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fluorine Compounds); 9679TC07X4 (Iodine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE


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[PMID]:29463523
[Au] Autor:Päkkilä F
[Ad] Endereço:University of Oulu and Oulu University Hospital, Department of Obstetrics and Gynaecology and Medical Research Centre, FI-90014 Oulu, Finland fanni.pakkila@oulu.fi.
[Ti] Título:Mild thyroid dysfunction in pregnancy and children's educational performance.
[So] Source:BMJ;360:k636, 2018 02 20.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Desempenho Acadêmico
Doenças da Glândula Tireoide
[Mh] Termos MeSH secundário: Criança
Escolaridade
Feminino
Seres Humanos
Gravidez
[Pt] Tipo de publicação:EDITORIAL; COMMENT
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.k636


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[PMID]:29424208
[Au] Autor:Tapeshkina NV; Perevalov AY
[Ti] Título:[Assessment of the efficiency of prevention of iodine deficiency among the children's population of the city of Mezhdurechensk of the Kemerovo region].
[So] Source:Gig Sanit;95(5):471-6, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:In the article there are presented results of a study of indices of ioduria in preschool kids and school children of the city of Mezhdurechensk (south of the Kemerovo region). 411 children aged of 3-17 years participated in the study. The median of ioduria on preschooler kids was 97,0 pg/l, and the proportion of urine samples with iodine levels less than 50 pg/l - 1,0%. The median of ioduria in school children is 98,0 pg/l, the percentage of urine samples with iodine levels less than 50 pg/l accounts for 1,3%. On average, on the population of children there was established that the percentage of urine samples with iodine levels from 50-100 pg/l (mild deficiency) was detected in 53,5% of children. Comparative analysis of indices of the level of ioduria according to data obtained in 2008 and 2014 in a group of school children showed that the measures taken to prevent diseases caused by iodine deficiency (the use of iodized salt in the diet of children and adolescents from organized groups on a regular basis) have given positive results.
[Mh] Termos MeSH primário: Iodo
Doenças da Glândula Tireoide
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Feminino
Indicadores Básicos de Saúde
Seres Humanos
Iodo/deficiência
Iodo/farmacologia
Iodo/urina
Masculino
Necessidades Nutricionais
População
Serviços de Saúde Escolar/organização & administração
Serviços de Saúde Escolar/estatística & dados numéricos
Sibéria/epidemiologia
Cloreto de Sódio na Dieta/farmacologia
Doenças da Glândula Tireoide/epidemiologia
Doenças da Glândula Tireoide/etiologia
Doenças da Glândula Tireoide/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sodium Chloride, Dietary); 0 (iodized salt); 9679TC07X4 (Iodine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE


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[PMID]:29412552
[Au] Autor:Geger EV; Zolotnikova GP
[Ti] Título:[Influence of radiating and chemical loads on changes of biochemical indices of the endocrine homeostasis in inhabitants from ecologically various areas of the Bryansk region].
[So] Source:Gig Sanit;95(5):422-8, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:There ecologic-hygienic ranging of all 27 areas of the Bryansk region was performed with the using of the innovative methodical approach with taking into account the integrated indices of total pollution of all objects of the environment. The analysis of results of the performed biochemical researches with studying of indices of the endocrine homeostasis in residents of ecologically various areas has allowed to evolve thyrotropic hormone TTH (Qcalc=2,4 at K=1,96) and thyroid hormone ST4 (Qcalc=3,684 at K=1,96) as biological markers of the negative impact of technogenic-chemical contamination of environment on human health.
[Mh] Termos MeSH primário: Poluição Ambiental
Substâncias Perigosas
Poluentes Radioativos
Doenças da Glândula Tireoide
[Mh] Termos MeSH secundário: Saúde Ambiental/métodos
Saúde Ambiental/organização & administração
Poluição Ambiental/efeitos adversos
Poluição Ambiental/prevenção & controle
Substâncias Perigosas/efeitos adversos
Substâncias Perigosas/análise
Seres Humanos
Determinação de Necessidades de Cuidados de Saúde
Poluentes Radioativos/efeitos adversos
Poluentes Radioativos/análise
Federação Russa/epidemiologia
Doenças da Glândula Tireoide/epidemiologia
Doenças da Glândula Tireoide/etiologia
Doenças da Glândula Tireoide/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hazardous Substances); 0 (Radioactive Pollutants)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE


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[PMID]:29187509
[Au] Autor:Scott ES; Long GV; Guminski A; Clifton-Bligh RJ; Menzies AM; Tsang VH
[Ad] Endereço:Department of EndocrinologyRoyal North Shore Hospital, Sydney, Australia.
[Ti] Título:The spectrum, incidence, kinetics and management of endocrinopathies with immune checkpoint inhibitors for metastatic melanoma.
[So] Source:Eur J Endocrinol;178(2):175-182, 2018 Feb.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Endocrine immune-related adverse events (endocrinopathies) are increasingly prevalent with the use of immune checkpoint inhibitors for the treatment of metastatic melanoma and other malignancies. There are no evidence-based guidelines for the screening or management of such patients. To describe the spectrum, incidence, kinetics and management of endocrinopathies with immune checkpoint inhibitors. DESIGN: A prospective study conducted at Melanoma Institute Australia between April 2014 and October 2015. METHODS: A total of 177 patients were treated with (a) ipilimumab ( = 15), (b) anti-PD-1 (nivolumab, pembrolizumab) ( = 103) or (c) combination ipilimumab and anti-PD-1 ( = 59) and were screened and managed for the subsequent endocrinopathies. The main outcome measures were the incidence and kinetics of endocrinopathy by immunotherapy drug class. RESULTS: Thirty-one patients (18%) developed an endocrine immune-related adverse event (thyroid dysfunction: 14%, hypophysitis: 6% and autoimmune diabetes: 0.6%). Combination immunotherapy was more likely to result in a single or multiple endocrinopathy compared to anti-PD-1 monotherapy (27% vs 9% and 7% vs 0% respectively, < 0.01). Endocrinopathies occurred after a median of 8 weeks from treatment commencement (range: 12-225 days), with combination immunotherapy resulting in significantly earlier onset compared to ipilimumab (median: 30 vs 76 days, = 0.046). The majority of endocrinopathies were identified in asymptomatic patients with hormonal screening. There were no baseline predictors for endocrinopathy. CONCLUSIONS: Combination immunotherapy has a greater risk of development of endocrinopathy compared to anti-PD-1 monotherapy. Regular biochemical profiling of patients, particularly within the first twelve weeks, results in early detection of endocrinopathy to minimise morbidity.
[Mh] Termos MeSH primário: Doenças do Sistema Endócrino/epidemiologia
Doenças do Sistema Endócrino/etiologia
Imunoterapia/efeitos adversos
Melanoma/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Anticorpos Monoclonais/efeitos adversos
Anticorpos Monoclonais/uso terapêutico
Anticorpos Monoclonais Humanizados/efeitos adversos
Austrália
Doenças Autoimunes/etiologia
Diabetes Mellitus/epidemiologia
Diabetes Mellitus/etiologia
Diabetes Mellitus/imunologia
Quimioterapia Combinada/efeitos adversos
Doenças do Sistema Endócrino/fisiopatologia
Feminino
Seres Humanos
Hipofisite/epidemiologia
Hipofisite/etiologia
Ipilimumab/efeitos adversos
Masculino
Meia-Idade
Receptor de Morte Celular Programada 1/imunologia
Estudos Prospectivos
Doenças da Glândula Tireoide/epidemiologia
Doenças da Glândula Tireoide/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Antibodies, Monoclonal, Humanized); 0 (Ipilimumab); 0 (PDCD1 protein, human); 0 (Programmed Cell Death 1 Receptor); 31YO63LBSN (nivolumab); DPT0O3T46P (pembrolizumab)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0810


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[PMID]:29175438
[Au] Autor:Ahmed RG; El-Gareib AW; Shaker HM
[Ad] Endereço:Division of Anatomy and Embryology, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt. Electronic address: r_g_a_ahmed@science.bsu.edu.eg.
[Ti] Título:Gestational 3,3',4,4',5-pentachlorobiphenyl (PCB 126) exposure disrupts fetoplacental unit: Fetal thyroid-cytokines dysfunction.
[So] Source:Life Sci;192:213-220, 2018 Jan 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Exposure to polychlorinated biphenyls (PCBs) is related to several endocrine disorders. This study examined the effect of maternal exposure of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) on the fetoplacental unit and fetal thyroid-cytokine axis during the pregnancy. Pregnant albino rats received PCB 126 (20 or 40µg/kgb.wt.) by oral gavage from gestation day (GD) 1 to 20. Potential effects of PCB 126 were evaluated by following the histopathological changes in the placenta by Haematoxylin and Eosin (H&E) stain and measuring the maternofetal thyroid axis (ELIZA), maternofetal body weight, and fetal growth markers (ELIZA), and cytokines (ELIZA) at embryonic day (ED) 20. Placental tissues of both treated groups showed hyperemia, hemorrhage, degeneration and apoptosis in labyrinth layer and spiral artery at GD 20. Both administrations of PCB 126 elevated serum thyrotropin (TSH) concentration, and decreased free thyroxine (FT4) and free triiodothyronine (FT3) concentrations, resulting in a maternofetal hypothyroidism. The presence of hypothyroidism increased fetal serum concentration of transforming growth factor-ß (TGF-ß), leptin (LEP), tumor necrosis factor-α (TNF-α), interleukin-1ß (IL-1ß), and decreased the fetal serum insulin growth factor-I (IGF-I), IGF-II, insulin, adiponectin (ADP), and growth hormone (GH) in both treated groups at ED 20. However, the increase in resistin (RETN) and interferon-γ (IFN-γ) was non-significant in low-dose group and highly significant in high-dose group. Simultaneously, the reduction in body weight of the dams and fetuses was observed in both PCB 126 groups of examined day with respect to the control group. The maternal PCB 126 distorted the fetoplacental unit might disrupt the fetal thyroid-cytokines axis and prenatal development.
[Mh] Termos MeSH primário: Citocinas/metabolismo
Poluentes Ambientais/toxicidade
Feto/efeitos dos fármacos
Placenta/efeitos dos fármacos
Bifenilos Policlorados/toxicidade
Doenças da Glândula Tireoide/induzido quimicamente
[Mh] Termos MeSH secundário: Adiponectina/biossíntese
Animais
Peso Corporal/efeitos dos fármacos
Feminino
Peso Fetal/efeitos dos fármacos
Feto/metabolismo
Hormônio do Crescimento/biossíntese
Fator de Crescimento Insulin-Like I/biossíntese
Fator de Crescimento Insulin-Like II/biossíntese
Placenta/metabolismo
Placenta/patologia
Gravidez
Ratos
Ratos Wistar
Tireotropina/sangue
Tiroxina/sangue
Tri-Iodotironina/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adiponectin); 0 (Cytokines); 0 (Environmental Pollutants); 0 (insulin-like growth factor II, rat); 0 (insulin-like growth factor-1, rat); 06LU7C9H1V (Triiodothyronine); 67763-96-6 (Insulin-Like Growth Factor I); 67763-97-7 (Insulin-Like Growth Factor II); 9002-71-5 (Thyrotropin); 9002-72-6 (Growth Hormone); DFC2HB4I0K (Polychlorinated Biphenyls); Q51BO43MG4 (Thyroxine); TSH69IA9XF (3,4,5,3',4'-pentachlorobiphenyl)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:28448414
[Au] Autor:Kim D; Kim DW; Heo YJ; Baek JW; Lee YJ; Park YM; Baek HJ; Jung SJ
[Ad] Endereço:From the *Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, Busan; †Department of Radiology, Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; and ‡Department of Pathology, Busan Paik Hospital, Inje University College of Medicine, Busan, South Korea.
[Ti] Título:Computed Tomography Features of Benign and Malignant Calcified Thyroid Nodules: A Single-Center Study.
[So] Source:J Comput Assist Tomogr;41(6):937-940, 2017 Nov/Dec.
[Is] ISSN:1532-3145
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: No previous studies have investigated thyroid calcification on computed tomography (CT) quantitatively by using Hounsfield unit (HU) values. This study aimed to analyze quantitative HU values of thyroid calcification on preoperative neck CT and to assess the characteristics of benign and malignant calcified thyroid nodules (CTNs). MATERIALS AND METHODS: Two hundred twenty patients who underwent neck CT before thyroid surgery from January 2015 to June 2016 were included. On soft-tissue window CT images, CTNs with calcified components of 3 mm or larger in minimum diameter were included in this study. The HU values and types of CTNs were determined and analyzed. RESULTS: Of 61 CTNs in 49 patients, there were 42 malignant nodules and 19 benign nodules. The mean largest diameter of the calcified component was 5.3 (2.5) mm (range, 3.1-17.1 mm). A statistically significant difference was observed in the HU values of calcified portions between benign and malignant CTNs, whereas there was no significant difference in patient age or sex or in the size, location, or type of each CTN. Of the 8 CTNs with pure calcification, 3 exhibited a honeycomb pattern on bone window CT images, and these 3 CTNs were all diagnosed as papillary thyroid carcinoma on histopathological examination. CONCLUSIONS: Hounsfield unit values of CTNs may be helpful for differentiating malignancy from benignity.
[Mh] Termos MeSH primário: Calcinose/diagnóstico por imagem
Doenças da Glândula Tireoide/diagnóstico por imagem
Nódulo da Glândula Tireoide/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Calcinose/complicações
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Doenças da Glândula Tireoide/complicações
Nódulo da Glândula Tireoide/complicações
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1097/RCT.0000000000000618


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[PMID]:28745667
[Au] Autor:Novikov AY; Kovalev VA; Vinichuk NV; Chernyh YA; Golub IE; Sorokina LV
[Ad] Endereço:Primorye regional clinical hospital #1, Vladivostok, Russia.
[Ti] Título:[Prevention and correction of cognitive dysfunction after general anesthesia].
[Ti] Título:Profilaktika i korrektsiia kognitivnykh narushenii posle obshchei anestezii..
[So] Source:Zh Nevrol Psikhiatr Im S S Korsakova;117(6):28-31, 2017.
[Is] ISSN:1997-7298
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:AIM: To evaluate clinical efficacy of intraoperative use of cytoflavin in the prevention and correction of cognitive functions in surgical patients with no history of neurological and psychosomatic disorders. MATERIAL AND METHODS: The study included 60 female patients who underwent surgery on the thyroid gland. Patients were stratified into two equal groups matched for main indices. Patients of the main group received infusions of cytoflavin (20 ml in 200 ml of 5% glucose solution). Patients underwent thyroidectomy with general inhalation anesthesia using desflurane. Cognitive testing was performed one day before operation and 6, 24 and 48 h after. Waking time after stopping desflurane administration and time prior tracheal extubation were recorded. RESULTS AND CONCLUSION: The use of cytoflavin promoted the early post anesthesia adaptation and more rapid recovery of initial cognitive status of the patients.
[Mh] Termos MeSH primário: Período de Recuperação da Anestesia
Anestesia por Inalação/efeitos adversos
Anestésicos Inalatórios/efeitos adversos
Disfunção Cognitiva/induzido quimicamente
Disfunção Cognitiva/prevenção & controle
Mononucleotídeo de Flavina/uso terapêutico
Inosina Difosfato/uso terapêutico
Niacinamida/uso terapêutico
Succinatos/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Anestésicos Inalatórios/administração & dosagem
Combinação de Medicamentos
Feminino
Seres Humanos
Cuidados Intraoperatórios
Isoflurano/administração & dosagem
Isoflurano/efeitos adversos
Isoflurano/análogos & derivados
Meia-Idade
Doenças da Glândula Tireoide/cirurgia
Tireoidectomia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anesthetics, Inhalation); 0 (Drug Combinations); 0 (Succinates); 0 (cytoflavin); 25X51I8RD4 (Niacinamide); 7N464URE7E (Flavin Mononucleotide); 86-04-4 (Inosine Diphosphate); CRS35BZ94Q (desflurane); CYS9AKD70P (Isoflurane)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.17116/jnevro20171176128-31


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[PMID]:29069018
[Au] Autor:Emamifar A; Hangaard J; Jensen Hansen IM
[Ad] Endereço:aDepartment of Rheumatology, Odense University Hospital, Svendborg Hospital, Svendborg bFaculty of Health Sciences, University of Southern Denmark, Odense cDepartment of Endocrinology, Odense University Hospital, Svendborg Hospital, Svendborg dDANBIO Registry, Copenhagen, Denmark.
[Ti] Título:Thyroid disorders in patients with newly diagnosed rheumatoid arthritis is associated with poor initial treatment response evaluated by disease activity score in 28 joints-C-reactive protein (DAS28-CRP): An observational cohort study.
[So] Source:Medicine (Baltimore);96(43):e8357, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To determine the prevalence of thyroid disorders among newly diagnosed rheumatoid arthritis (RA) patients and evaluate the association between clinical characteristics of RA and thyroid disorders, and also initial treatment response in the RA patients with thyroid disorders.Newly diagnosed, adult RA patients who were diagnosed according to the new 2010 American College of Rheumatology/European League Against Rheumatism criteria since January 1, 2010, were included. Patients' demographic data, serology results including immunoglobulin M rheumatoid factor (IgM RF), anticyclic citrullinated peptide antibody (anti-CCP), and antinuclear antibody (ANA), and also disease activity score in 28 joints-C-reactive protein at the time of diagnosis and after 4 months (±1-2 months) of treatment initiation were extracted from Danish Danbio Registry. Patients' electronic hospital records for the past 10 years were reviewed to reveal if they had been diagnosed with thyroid disorders or they had abnormal thyroid test.In all, 439 patients were included, female 60.1%, mean age 64.6 ±â€Š15.0 years and disease duration 2.6 ±â€Š1.7 years. Prevalence of thyroid disorders was 69/439 (15.7%) and hypothyroidism was the most frequent disorder (30.4%). The presence of thyroid disorders among RA patients was significantly associated with female sex (P < .001), ANA positivity (P = .04), and anti-CCP ≥100 EU/mL (P = .05). Furthermore, RA patients with thyroid disorders had significantly poorer initial response to RA treatment compared with patients with isolated RA after 4 months of treatment (P = .02). There were no associations between thyroid disorders and age, disease duration, and also IgM RF positivity.Presence of thyroid disorders in RA patients is suggestive of a more aggressive disease and poor outcome, with direct effect on initial treatment response. To diagnose concurrent thyroid disorders at an earlier stage, routine measurement of serum thyroid-stimulating hormone is recommended in all RA patients at the time of diagnosis and with yearly interval thereafter.
[Mh] Termos MeSH primário: Antirreumáticos/uso terapêutico
Artrite Reumatoide/complicações
Proteína C-Reativa/análise
Índice de Gravidade de Doença
Doenças da Glândula Tireoide/sangue
[Mh] Termos MeSH secundário: Idoso
Anticorpos Antinucleares/sangue
Artrite Reumatoide/sangue
Artrite Reumatoide/tratamento farmacológico
Autoanticorpos/sangue
Estudos de Coortes
Dinamarca
Feminino
Seres Humanos
Imunoglobulina M/sangue
Articulações/patologia
Masculino
Meia-Idade
Peptídeos Cíclicos/imunologia
Prevalência
Sistema de Registros
Fator Reumatoide/sangue
Doenças da Glândula Tireoide/complicações
Doenças da Glândula Tireoide/epidemiologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Antibodies, Antinuclear); 0 (Antirheumatic Agents); 0 (Autoantibodies); 0 (Immunoglobulin M); 0 (Peptides, Cyclic); 0 (cyclic citrullinated peptide); 9007-41-4 (C-Reactive Protein); 9009-79-4 (Rheumatoid Factor)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008357


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[PMID]:29068988
[Au] Autor:Chen KC; Iqbal U; Nguyen PA; Hsu CH; Huang CL; Hsu YE; Atique S; Islam MM; Li YJ; Jian WS
[Ad] Endereço:aGraduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan bInternational Center for Health Information Technology (ICHIT), Taipei Medical University, Taipei, Taiwan cDepartment of Dermatology, Wan Fang Hospital, Taipei, Taiwan dDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan eSchool of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan fSchool of Health Care Administration, Taipei Medical University, Taipei, Taiwan gFaculty of Health Sciences, Macau University of Science and Technology, Macau, China hMaster Program in Global Health and Development, College of Public Health, Taipei Medical University, Taipei, Taiwan.
[Ti] Título:The impact of different surgical procedures on hypoparathyroidism after thyroidectomy: A population-based study.
[So] Source:Medicine (Baltimore);96(43):e8245, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The main objective of this study is to investigate the outcome between surgical procedures and the risk of development of hypoparathyroidism followed by surgical procedure in patients with thyroid disorders.We analyzed the data acquired from Taiwan's Bureau of National Health Insurance (BNHI) research database from 1998 to 2011 and found 9316 patients with thyroid surgery. Cox regression model was used to calculate the hazard ratio (HR).A count of 314 cases (3.4%) of hypoparathyroidism was identified. The 9 years cumulated incidence of hypoparathyroidism was the highest in patient undergone bilateral total thyroidectomy (13.5%) and the lowest in the patient with unilateral subtotal thyroidectomy (1.2%). However, in the patients who had undergone unilateral subtotal, the risk was the highest in bilateral total (HR: 11.86), followed by radical thyroidectomy with unilateral neck lymph node dissection (HR: 8.56), unilateral total (HR, 4.39), and one side total and another side subtotal (HR: 2.80).The extent of thyroid resection determined the risk of development of hypoparathyroidism. It is suggested that the association of these factors is investigated in future studies.
[Mh] Termos MeSH primário: Hipoparatireoidismo/epidemiologia
Hipoparatireoidismo/etiologia
Complicações Pós-Operatórias
Tireoidectomia/efeitos adversos
Tireoidectomia/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Incidência
Excisão de Linfonodo/efeitos adversos
Fatores de Risco
Taiwan/epidemiologia
Doenças da Glândula Tireoide/cirurgia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008245



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