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[PMID]:29172409
[Au] Autor:Tigabu E; Bekele KB; Dachew BA
[Ad] Endereço:Ethiopian Paediatric Association, Amhara Region, Bahir Dar, Ethiopia.
[Ti] Título:Prevalence of goiter and associated factors among schoolchildren in northeast Ethiopia.
[So] Source:Epidemiol Health;39:e2017055, 2017.
[Is] ISSN:2092-7193
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Goiter is a major public health problem, especially in developing countries such as Ethiopia. Hence, this study aimed to assess the prevalence and associated factors of goiter among children in Waghimra Zone, northeast Ethiopia. METHODS: A cross-sectional study was conducted from April 8 to 25, 2015 in northeast Ethiopia. A multistage sampling method was used to select 454 schoolchildren. Data were collected using a pre-tested structured interviewer-administered questionnaire. Children were examined for the presence or absence of goiter based on the criteria of the United Nations Children's Fund, International Council for the Control of Iodine Deficiency, and the World Health Organization. Salt samples from children's homes were tested for iodine levels using a rapid iodized salt test kit. Data were entered into EpiInfo version 7 and exported to SPSS version 20 for analysis. Bivariate and multivariate logistic regression models were fitted, and adjusted odds ratio (aOR) with 95% confidence interval (CI) were computed to determine the level of significance. RESULTS: The prevalence of goiter was 62.1% (95% CI, 57.5 to 66.5%). Being female (aOR, 3.09; 95% CI, 1.57 to 6.08), having a family history of goiter (aOR, 5.18; 95% CI, 2.43 to 11.03), and using non-iodized salt (aOR, 2.20; 95% CI, 1.12 to 4.38) were factors associated with goiter among schoolchildren. CONCLUSIONS: The prevalence of goiter was high. Being female and having a family history of goiter increased the risk of goiter in children, but using iodized salt was protective. Therefore, we recommend ensuring universal access to iodized salt and increasing the awareness of the community of the importance of iodized salt utilization.
[Mh] Termos MeSH primário: Bócio/epidemiologia
[Mh] Termos MeSH secundário: Criança
Estudos Transversais
Etiópia/epidemiologia
Feminino
Seres Humanos
Iodo/administração & dosagem
Masculino
Anamnese
Prevalência
Fatores de Risco
Distribuição por Sexo
Cloreto de Sódio na Dieta/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sodium Chloride, Dietary); 0 (iodized salt); 9679TC07X4 (Iodine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.4178/epih.e2017055


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[PMID]:29066572
[Au] Autor:Villarroya-Marquina I; Sancho J; Lorente-Poch L; Gallego-Otaegui L; Sitges-Serra A
[Ad] Endereço:Endocrine Surgery UnitHospital del Mar, Departament de Cirurgia, Universitat Autònoma de Barcelona, Barcelona, Spain.
[Ti] Título:Time to parathyroid function recovery in patients with protracted hypoparathyroidism after total thyroidectomy.
[So] Source:Eur J Endocrinol;178(1):105-113, 2018 Jan.
[Is] ISSN:1479-683X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Hypocalcaemia is the most common adverse effect after total thyroidectomy. It recovers in about two-thirds of the patients within the first postoperative month. Little is known, however, about recovery of the parathyroid function (RPF) after this time period. The aim of the present study was to investigate the time to RPF in patients with protracted (>1 month) hypoparathyroidism after total thyroidectomy. DESIGN: Cohort prospective observational study. METHODS: Adult patients undergoing total thyroidectomy for goitre or thyroid cancer. Cases with protracted hypoparathyroidism were studied for RPF during the following months. Time to RPF and variables associated with RPF or permanent hypoparathyroidism were recorded. RESULTS: Out of 854 patients undergoing total thyroidectomy, 142 developed protracted hypoparathyroidism. Of these, 36 (4.2% of the entire cohort) developed permanent hypoparathyroidism and 106 recovered: 73 before 6 months, 21 within 6-12 months and 12 after 1 year follow-up. Variables significantly associated with RPF were the number of parathyroid glands remaining (not autografted nor inadvertently resected) and a serum calcium concentration >2.25 mmol/L at one postoperative month. Late RPF (>6 months) was associated with surgery for thyroid cancer. RPF was still possible after one year in patients with four parathyroid glands preserved and serum calcium concentration at one month >2.25 mmol/L. CONCLUSIONS: Permanent hypoparathyroidism should not be diagnosed in patients requiring replacement therapy for more than six months, especially if the four parathyroid glands were preserved.
[Mh] Termos MeSH primário: Hipoparatireoidismo/etiologia
Hipoparatireoidismo/fisiopatologia
Glândulas Paratireoides/fisiopatologia
Complicações Pós-Operatórias/fisiopatologia
Tireoidectomia/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Cálcio/sangue
Estudos de Coortes
Feminino
Seguimentos
Bócio/cirurgia
Seres Humanos
Masculino
Meia-Idade
Hormônio Paratireóideo/sangue
Período Pós-Operatório
Estudos Prospectivos
Recuperação de Função Fisiológica
Neoplasias da Glândula Tireoide/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Parathyroid Hormone); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171129
[Lr] Data última revisão:
171129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1530/EJE-17-0589


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Brandao, Lenine Garcia
[PMID]:28658344
[Au] Autor:Rodrigues MG; Araujo VJF; Matos LL; Hojaij FC; Simões CA; Araujo VJF; Ramos DM; Mahmoud RL; Mosca LM; Manta GB; Volpi EM; Brandão LG; Cernea CR
[Ad] Endereço:Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brasil.
[Ti] Título:Substernal goiter and laryngopharyngeal reflux.
[So] Source:Arch Endocrinol Metab;61(4):348-353, 2017 Jul-Aug.
[Is] ISSN:2359-4292
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This study aims to compare the prevalence of laryngopharyngeal reflux signs between two groups of patients undergoing thyroidectomy for voluminous goiter: substernal goiters and voluminous cervical goiter without thoracic extension. SUBJECTS AND METHODS: A retrospective case-control study was performed with data retrieved of the charts of the patients submitted to thyroidectomies occurred at a tertiary care center (Head and Neck Surgery Department, University of São Paulo Medical School) between 2010 and 2014. The selected thyroidectomies were allocated in two groups for study: patients with substernal goiters and patients with voluminous cervical goiter without thoracic extension. Cervical goiters were selected by ultrasonography mensuration. Clinical criterion was used to define substernal goiter. RESULTS: The average thyroid volume in patients with substernal goiter was significantly greater than the average volume in patients with only cervical goiter (p < 0.001). The prevalence of signs of reflux laryngitis at laryngoscopy was significantly greater in substernal goiter patients (p = 0.036). Moreover, substernal goiter was considered as the unique independent variable for high reflux laryngitis signs at laryngoscopy (OR = 2.75; CI95%: 1.05-7.20; p = 0.039) when compared to only cervical goiter patients. CONCLUSION: This study shows a significant association between substernal goiters and signs of laryngopharyngeal reflux at preoperative laryngoscopy. Therefore, when compared with voluminous cervical goiters, the substernal goiters increase the chance of reflux laryngitis signs in patients.
[Mh] Termos MeSH primário: Bócio Subesternal/epidemiologia
Refluxo Laringofaríngeo/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos de Casos e Controles
Feminino
Bócio/complicações
Bócio/epidemiologia
Bócio/fisiopatologia
Bócio/cirurgia
Bócio Subesternal/complicações
Bócio Subesternal/fisiopatologia
Bócio Subesternal/cirurgia
Seres Humanos
Refluxo Laringofaríngeo/complicações
Refluxo Laringofaríngeo/diagnóstico por imagem
Laringoscopia
Masculino
Meia-Idade
Prevalência
Estudos Retrospectivos
Tireoidectomia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE


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[PMID]:28612896
[Au] Autor:Cappellani A; Zanghì A; Cardì F; Cavallaro A; Piccolo G; Palmucci S; Fuccio Sanzà G; Di Vita M
[Ad] Endereço:Department of Surgery and Medical and Surgical Specialties, General And Breast Surgery Unit, University of Catania.
[Ti] Título:Total Thyroidectomy: the first, the best. The recurrent goiter issue.
[So] Source:Clin Ter;168(3):e194-e198, 2017 May-Jun.
[Is] ISSN:1972-6007
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Redo surgery for recurrent goiter is still now, even in experienced hands, followed by higher morbidity than primary total thyroidectomy. Suppressive Levothyroxine therapy failed to improve the recurrence rate, while inducing a subclinical hyperthyroidism. Aim of this study is to verify morbidity after total thyroidectomy for benign thyroid diseases, both primary and after recurrence. MATERIALS AND METHODS: A series of 20 cases of total thyroidectomy for recurrent benign diseases (RG), performed between January 2001 and December 2013 was compared with 225 cases of primary total thyroidectomy (PT) . Cancers, even incidentally diagnosed, were excluded. At least a 12 months follow up was accomplished. Due to the small size of the sample for RG, statistical analysis was performed by Fisher test only. RESULTS: Postoperative complications were Transient hypocalcemia: 5 (25%) in RG and 18 (8%) in PT, Permanent hypocalcemia only 2 (10%) in RG (significant for p <0,05), Transient RLN deficit 5 (25 %) in RG and 6 (2.6%) in PT (significant for p< 0.05). CONCLUSIONS: Differences in incidence of perioperative complications cannot be advocated to justify a less than total thyroidectomy even in benign disease setting. The need for a redo surgery with its burden of morbidity is per se a good reason to avoid a conservative surgery. Further, suppressive therapy with Levothyroxine often fails to avoid recurrence, inducing in some cases a specific morbidity. Our experience confirms the results of our previous experiences and of literature on this topic: the best management of recurrent goiter is its prevention by primary total thyroidectomy.
[Mh] Termos MeSH primário: Bócio/cirurgia
Doenças da Glândula Tireoide/cirurgia
Tireoidectomia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Bócio/epidemiologia
Seres Humanos
Hipertireoidismo/complicações
Incidência
Masculino
Morbidade
Complicações Pós-Operatórias/epidemiologia
Recidiva
Reoperação
Estudos Retrospectivos
Doenças da Glândula Tireoide/complicações
Tireoidectomia/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.7417/T.2017.2005


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[PMID]:28582818
[Au] Autor:Mo Z; Wang XF; Mao GM; Zhu WM; Xu PW; Zou Y; Wang YY; Lou XM
[Ad] Endereço:Environment and Occupational Health Department, Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou, China.
[Ti] Título:Goitre and urinary iodine in coastal and inland areas with low and high iodized salt coverage in Zhejiang province, China.
[So] Source:Asia Pac J Clin Nutr;26(4):671-679, 2017.
[Is] ISSN:0964-7058
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: WHO recommended that iodized salt are more than 90% of households in USI programs, which may not be suitable for all regions, especially in coastal areas. This study intended to find out levels of iodine nutrition and give advice from the USI programs for areas with different iodized salt coverage. METHODS AND STUDY DESIGN: Coastal and inland areas were selected according to geographical regions in Zhejiang Province, China. The water iodine concentration (spectrophotometer analysis), salt iodine concentration (the colorimetric titration method), salt intake, urinary iodine concentration (spectrophotometer analysis), and thyroid volume examination (ultrasonography), as well as questionnaire, were measured in the two areas. RESULTS: Mean Urinary Iodine concentration (MUIs) of children in coastal areas was 149 µg/L, which was significantly lower than that in inland areas (191 µg/L). MUIs of pregnant women in coastal and inland areas were111 and 138 µg/L, respectively. Pregnant women who consumed iodine-containing supplements had higher MUIs (207 µg/L) than those did not (134 µg/L) in inland areas. Prevalence of goitre in children reached 7.0% and 6.6% in coastal and inland areas, respectively. The lowest prevalence of goitre was reached when the urinary iodine concentration was approximately 120-160 µg/L in coastal areas. CONCLUSION: Iodine levels of coastal and inland areas were in the adequate range. Advice from the USI program should be specialized for different areas to appropriately reduce the salt iodine concentrations in inland areas and to determine an appropriate proportion of households using iodized salt in coastal areas. Moreover, iodine supplement intake during pregnancy should officially be recommended.
[Mh] Termos MeSH primário: Bócio/epidemiologia
Iodo/urina
Cloreto de Sódio na Dieta/análise
[Mh] Termos MeSH secundário: Criança
China/epidemiologia
Características da Família
Feminino
Seres Humanos
Iodo/administração & dosagem
Masculino
Prevalência
Cloreto de Sódio na Dieta/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sodium Chloride, Dietary); 0 (iodized salt); 9679TC07X4 (Iodine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE
[do] DOI:10.6133/apjcn.052016.06


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[PMID]:28535654
[Au] Autor:Geng WJ; Shan LB; Wang JS; Li N; Wu YM
[Ad] Endereço:Department of Pathology, Xiaolan Hospital, Nanfang Medical College, Zhongshan 528415, China.
[Ti] Título:[Expression and significance of Nrf2 in papillary thyroid carcinoma and thyroid goiter].
[So] Source:Zhonghua Zhong Liu Za Zhi;39(5):367-368, 2017 May 23.
[Is] ISSN:0253-3766
[Cp] País de publicação:China
[La] Idioma:chi
[Mh] Termos MeSH primário: Carcinoma/metabolismo
Bócio/metabolismo
Fator 2 Relacionado a NF-E2/metabolismo
Proteínas de Neoplasias/metabolismo
Neoplasias da Glândula Tireoide/metabolismo
[Mh] Termos MeSH secundário: Carcinoma Papilar
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (NF-E2-Related Factor 2); 0 (NFE2L2 protein, human); 0 (Neoplasm Proteins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170525
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0253-3766.2017.05.009


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[PMID]:28436636
[Au] Autor:Chen Y; Liang L; Fang Y; Wang C; Li L; Jiang T
[Ad] Endereço:Department of Pediatrics, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
[Ti] Título:[Iodine 131 joint radio frequency ablation treatment for child with hyperthyroidism goiter: one case report].
[So] Source:Zhejiang Da Xue Xue Bao Yi Xue Ban;46(1):89-91, 2017 Jan 25.
[Is] ISSN:1008-9292
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:A 12-year-old girl presented with a history of cervical mass, and one week of throat discomfort and dyspnea. Five years ago, the patient was diagnosed as Hashimoto's thyroiditis and hyperthyroidism; she received antithyroid drug treatment, but the result was not satisfactory. B-ultrasonic showed that the size of thyroid gland was 8.1 cm×3.2 cm in the left and 8.2 cm×4.8 cm in the right. After iodine 131 combined with radiofrequency ablation (RFA) treatment, throat discomfort and recumbent breathing difficulties disappeared, and B-ultrasonic showed that the size of thyroid reduced to 2.3 cm×1.7 cm (left) and 2.8 cm×2.0 cm (right). No recurrence was observed during the two and a half years of follow-up.
[Mh] Termos MeSH primário: Técnicas de Ablação/métodos
Bócio/terapia
Hipertireoidismo/terapia
Radioisótopos do Iodo/uso terapêutico
Ondas de Rádio/uso terapêutico
[Mh] Termos MeSH secundário: Criança
Dispneia/etiologia
Dispneia/terapia
Feminino
Bócio/complicações
Bócio/diagnóstico por imagem
Bócio/patologia
Doença de Hashimoto/terapia
Seres Humanos
Ultrassonografia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iodine Radioisotopes)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE


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[PMID]:28424141
[Au] Autor:Kul F; Kirdak T; Sarkut P; Ocakoglu G; Korun N
[Ti] Título:Can Parathormon Levels after Ipsilateral Lobectomy Predict Postoperative Hypocalcemia in Patients Undergoing Total Thyroidectomy?
[So] Source:Am Surg;83(4):421-427, 2017 Apr 01.
[Is] ISSN:1555-9823
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to investigate the relationship between the serum parathormone (PTH) levels measured after completion of hemithyroidectomy on the first side during total thyroidectomy and the postoperative hypocalcemia. The patients were divided into two groups, as those who demonstrated a decrease in PTH levels measured after completion of hemithyroidectomy of the first side (Group 1, n = 43) and those who did not demonstrate a decrease in PTH levels (Group 2, n = 24). The serum PTH levels were measured just before the incision (PTHi), when the hemithyroidectomy stage had been completed (PTHht), at the end of the operation (PTHtt), and at the postoperative 24th hour (PTH24hr). The serum total calcium (Ca2+) levels were also measured. The median percentage differences in PTHtt levels based on basal PTHi levels of Groups 1 and 2 were -60.6 and -15.7 per cent, respectively, P = 0.001. The frequency of postoperative biochemical hypocalcemia was higher in Group 1, P < 0.05. It was determined that a 10 per cent or higher decrease in PTHht levels in Group 1 could predict biochemical hypocalcemia at the postoperative 24th hour. In conclusions, postoperative hypocalcemia is seen more frequent in patients with a decrease of PTHht during total thyroidectomy. A decrease of 10 per cent in PTHht levels measured after ipsilateral lobectomy and a 62 per cent or higher decrease in PTHtt levels measured in the end of the total thyroidectomy could be helpful for prediction of postoperative hypocalcemia in these patients.
[Mh] Termos MeSH primário: Bócio/cirurgia
Hipocalcemia/sangue
Hormônio Paratireóideo/sangue
Complicações Pós-Operatórias/sangue
Tireoidectomia/métodos
[Mh] Termos MeSH secundário: Cálcio/sangue
Feminino
Seres Humanos
Masculino
Meia-Idade
Valor Preditivo dos Testes
Estudos Prospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Parathyroid Hormone); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE


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[PMID]:28332879
[Au] Autor:Willard DL; Young LS; He X; Braverman LE; Pearce EN
[Ti] Título:IODINE CONTENT OF ENTERAL AND PARENTERAL NUTRITION SOLUTIONS.
[So] Source:Endocr Pract;23(7):775-779, 2017 Jul.
[Is] ISSN:1530-891X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Iodine is essential for thyroid hormone synthesis, and iodine deficiency may result in thyroid disorders including goiter and hypothyroidism. Patients on long-term enteral nutrition (EN) or parenteral nutrition (PN) may be at risk for micronutrient deficiencies. The recommended daily allowance for iodine intake is 150 µg for nonpregnant adults. However, there is no current consensus among scientific societies regarding the quantity of iodine to be added in adult EN and PN formulations. The objective of this study was to determine the iodine content of U.S. adult enteral and parenteral nutrition solutions. This study also aimed to determine whether adult patients in the United States who are receiving long-term artificial nutrition may be at risk for iodine deficiency. METHODS: Ten enteral nutrition solutions and 4 parenteral nutrition solutions were evaluated. The iodine contents of these solutions were measured spectrophotometrically and compared to the labeled contents. RESULTS: Measured and labeled EN iodine contents were similar (range 131-176 µg/L and 106-160 µg/L, respectively). In contrast, PN formulas were found to contain small, unlabeled amounts of iodine, averaging 27 µg/L. CONCLUSION: Typical fluid requirements are 30 to 40 mL/kg/day for adults receiving either total EN (TEN) or total PN (TPN). Adults on long-term TEN likely consume enough servings to meet their daily iodine requirements. However, patients on long-term TPN would require on average 5.6 L PN/day to meet the recommended daily allowance of iodine. This volume of PN is far in excess of typical consumption. Thus, U.S. patients requiring long-term TPN may be at risk for iodine deficiency. ABBREVIATIONS: EN = enteral nutrition; PN = parenteral nutrition; TEN = total enteral nutrition; TPN = total parenteral nutrition; UIC = urinary iodine concentration.
[Mh] Termos MeSH primário: Nutrição Enteral
Iodo/análise
Soluções de Nutrição Parenteral/química
Nutrição Parenteral Total
[Mh] Termos MeSH secundário: Adulto
Bócio
Seres Humanos
Hipotireoidismo
Iodo/deficiência
Nutrição Parenteral
Soluções Farmacêuticas/química
Guias de Prática Clínica como Assunto
Recomendações Nutricionais
Risco
Espectrofotometria
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Parenteral Nutrition Solutions); 0 (Pharmaceutical Solutions); 9679TC07X4 (Iodine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.4158/EP161692.OR


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[PMID]:28328929
[Au] Autor:Xiu L; Zhong G; Ma X
[Ad] Endereço:School of Basic Medical Science, Beijing University of Chinese Medicine, Beijing, China.
[Ti] Título:Urinary iodine concentration (UIC) could be a promising biomarker for predicting goiter among school-age children: A systematic review and meta-analysis.
[So] Source:PLoS One;12(3):e0174095, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To evaluate whether urinary iodine concentration (UIC) can predict goiter among school-age children, and to assess the association between UIC and goiter prevalence. METHODS: We searched the MEDLINE, EMBASE, Cochrane Library (Cochrane Database of Systematic Reviews), Web of Science, CNKI, VIP, and Wan Fang databases for relevant reports in both English and Chinese up to August 25, 2016. The mean differences (MD) and 95% confidence intervals (CI) were calculated for the UIC and goiter prevalence assessments. Pooled odds ratios and 95% CIs were used to compare the prevalences of goiter in the different UIC groups. RESULTS: We identified 11 case-control studies, and found that children with goiter had lower UIC values, compared to children without goiter (MD: -1.82, 95% CI: -3.24, -0.40, p < 0.05). An increased risk of goiter was associated with UIC values of < 20 µg/L or > 200 µg/L. CONCLUSION: The results of our meta-analysis suggest that lower UIC values were associated with an increased risk of goiter, and that iodine deficiency may lead to an increased risk of goiter. Furthermore, we observed U-shaped relationships between UIC and the prevalence of goiter, which suggests that both severe iodine deficiency and excessive iodine intake may lead to increased risks of goiter.
[Mh] Termos MeSH primário: Biomarcadores/urina
Bócio/diagnóstico
Bócio/urina
Iodo/urina
[Mh] Termos MeSH secundário: Adolescente
Estudos de Casos e Controles
Criança
Feminino
Bócio/epidemiologia
Seres Humanos
Masculino
Prevalência
Doenças da Glândula Tireoide/diagnóstico
Doenças da Glândula Tireoide/epidemiologia
Doenças da Glândula Tireoide/urina
Glândula Tireoide/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
0 (Biomarkers); 9679TC07X4 (Iodine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0174095



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