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  1 / 19664 MEDLINE  
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[PMID]:29443784
[Au] Autor:Namatame C; Sonoo T; Fukushima K; Naraba H; Hashimoto H; Nakamura K
[Ad] Endereço:Department of Emergency and Critical Care Medicine, Hitachi General Hospital, Johnan-cho, Hitachi, Ibaraki, Japan.
[Ti] Título:A thyroid storm patient with protracted disturbance of consciousness and reversible lesion in the splenium of corpus callosum: A case report.
[So] Source:Medicine (Baltimore);97(7):e9949, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Various neurological manifestations are observed in thyroid storm patients but protracted disturbance of consciousness is rare. PATIENT CONCERNS: A 58-year-old male was admitted to our hospital after a traffic accident. DIAGNOSES: Although awake on arrival, he fell into coma after admission. Based on the clinical symptoms and hyperthyroidism, the patient was diagnosed with thyroid storm (TS). INTERVENTIONS: Even after improvement of hyperthyroidism, disturbance of consciousness was protracted. Considering the possibility of immune-related etiology, methylprednisolone pulse was started. OUTCOMES: His consciousness level improved over a 3-month period, and he became able to walk with some assistance after 6 months. LESSONS: His condition was atypical of TS-associated encephalopathy because of the long clinical course. Reversible splenial lesion was visible using brain imaging. In some cases of TS, disturbance of consciousness can be protracted for several months, but it is reversible. Therefore, it is necessary to judge the long-term neurological outcome carefully.
[Mh] Termos MeSH primário: Coma/etiologia
Corpo Caloso/diagnóstico por imagem
Crise Tireóidea/complicações
Crise Tireóidea/diagnóstico por imagem
[Mh] Termos MeSH secundário: Acidentes de Trânsito
Coma/diagnóstico por imagem
Glucocorticoides/uso terapêutico
Seres Humanos
Hipertireoidismo/complicações
Hipertireoidismo/tratamento farmacológico
Imagem por Ressonância Magnética
Masculino
Metilprednisolona/uso terapêutico
Meia-Idade
Crise Tireóidea/tratamento farmacológico
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids); X4W7ZR7023 (Methylprednisolone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009949


  2 / 19664 MEDLINE  
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[PMID]:29253128
[Au] Autor:Mohácsik P; Erdélyi F; Baranyi M; Botz B; Szabó G; Tóth M; Haltrich I; Helyes Z; Sperlágh B; Tóth Z; Sinkó R; Lechan RM; Bianco AC; Fekete C; Gereben B
[Ad] Endereço:Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary.
[Ti] Título:A Transgenic Mouse Model for Detection of Tissue-Specific Thyroid Hormone Action.
[So] Source:Endocrinology;159(2):1159-1171, 2018 02 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Thyroid hormone (TH) is present in the systemic circulation and thus should affect all cells similarly in the body. However, tissues have a complex machinery that allows tissue-specific optimization of local TH action that calls for the assessment of TH action in a tissue-specific manner. Here, we report the creation of a TH action indicator (THAI) mouse model to study tissue-specific TH action. The model uses a firefly luciferase reporter readout in the context of an intact transcriptional apparatus and all elements of TH metabolism and transport and signaling. The THAI mouse allows the assessment of the changes of TH signaling in tissue samples or in live animals using bioluminescence, both in hypothyroidism and hyperthyroidism. Beyond pharmacologically manipulated TH levels, the THAI mouse is sufficiently sensitive to detect deiodinase-mediated changes of TH action in the interscapular brown adipose tissue (BAT) that preserves thermal homeostasis during cold stress. The model revealed that in contrast to the cold-induced changes of TH action in the BAT, the TH action in this tissue, at room temperature, is independent of noradrenergic signaling. Our data demonstrate that the THAI mouse can also be used to test TH receptor isoform-specific TH action. Thus, THAI mouse constitutes a unique model to study tissue-specific TH action within a physiological/pathophysiological context and test the performance of thyromimetics. In conclusion, THAI mouse provides an in vivo model to assess a high degree of tissue specificity of TH signaling, allowing alteration of tissue function in health and disease, independently of changes in circulating levels of TH.
[Mh] Termos MeSH primário: Genes Reporter
Elementos de Resposta
Hormônios Tireóideos/farmacologia
Hormônios Tireóideos/fisiologia
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Feminino
Regulação da Expressão Gênica
Células HEK293
Seres Humanos
Hipertireoidismo/genética
Hipertireoidismo/metabolismo
Hipotireoidismo/genética
Hipotireoidismo/metabolismo
Iodeto Peroxidase/genética
Iodeto Peroxidase/metabolismo
Masculino
Camundongos
Camundongos Transgênicos
Modelos Animais
Especificidade de Órgãos/efeitos dos fármacos
Especificidade de Órgãos/genética
Transdução de Sinais/efeitos dos fármacos
Transdução de Sinais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Thyroid Hormones); EC 1.11.1.8 (Iodide Peroxidase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1210/en.2017-00582


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[PMID]:28740583
[Au] Autor:Osuna PM; Udovcic M; Sharma MD
[Ad] Endereço:Houston Methodist Hospital, Houston, Texas.
[Ti] Título:Hyperthyroidism and the Heart.
[So] Source:Methodist Debakey Cardiovasc J;13(2):60-63, 2017 Apr-Jun.
[Is] ISSN:1947-6108
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Thyroid hormones have a significant impact on cardiac function and structure. Excess thyroid hormone affects cardiovascular hemodynamics, leading to high-output heart failure and, in late stages, dilated cardiomyopathy. In this review, we discuss how hyperthyroidism affects cardiovascular pathophysiology and molecular mechanisms and examine the complications caused by excess thyroid hormone, such as heart failure and atrial fibrillation.
[Mh] Termos MeSH primário: Cardiopatias/fisiopatologia
Coração/fisiopatologia
Hipertireoidismo/fisiopatologia
Glândula Tireoide/fisiopatologia
[Mh] Termos MeSH secundário: Metabolismo Energético
Cardiopatias/diagnóstico
Cardiopatias/epidemiologia
Cardiopatias/prevenção & controle
Hemodinâmica
Seres Humanos
Hipertireoidismo/diagnóstico
Hipertireoidismo/epidemiologia
Hipertireoidismo/terapia
Prognóstico
Medição de Risco
Fatores de Risco
Glândula Tireoide/metabolismo
Hormônios Tireóideos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Thyroid Hormones)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.14797/mdcj-13-2-60


  4 / 19664 MEDLINE  
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[PMID]:29246135
[Au] Autor:Hwang JH; Kang SY; Kang AN; Jung HW; Jung C; Jeong JH; Park YK
[Ad] Endereço:Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Gachon University, Seongnam, 13120, Republic of Korea.
[Ti] Título:MOK, a pharmacopuncture medicine, regulates thyroid dysfunction in L-thyroxin-induced hyperthyroidism in rats through the regulation of oxidation and the TRPV1 ion channel.
[So] Source:BMC Complement Altern Med;17(1):535, 2017 Dec 15.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In this study, we evaluated the therapeutic effect of MOK, a pharmacopuncture medicine, on thyroid dysfunction in L-thyroxin (LT4)-induced hyperthyroidism rats. METHODS: The experimental hyperthyroidism model was prepared by the intraperitoneal injection of LT4 (0.5 mg/kg) once daily for 2 weeks in SD rats. MOK extract was injected at doses of 0.3 or 3 mg/kg on acupuncture points in the thyroid glands of LT4-induced hypothyroidism rats once a day for 2 weeks. The body temperature, body weight, and food/water intake were measured once a week for 2 weeks. The levels of thyroid hormones, total cholesterol, LDL-cholesterol, GOT, and GPT were measured in the sera of rats using ELISA and an automatic blood analyzer. The histological changes of thyroid tissues were observed by H&E staining. The expression of thermo-regulating protein, TRPV1 was determined by western blot in dorsal root ganglion (DRG) and brain tissues. We also measured the contents of GSH in the liver and antioxidant enzymes, SOD, and catalase in the liver, heart, and brain tissues by enzyme-based assay and Western blot, respectively. RESULTS: The acupuncture of MOK extract on the thyroid gland of LT4-induced hyperthyroidism rats significantly decreased the body temperature, and did not change body weight and food and water intakes. MOK acupuncture significantly increased the level of TSH, and decreased the levels of T3 and T4 in hyperthyroidism rats. The expression of TRPV1 was inhibited in both DRG and brain tissues after MOK acupuncture, and the levels of GOT, GPT, total cholesterol, and LDL-cholesterol were also decreased. MOK acupuncture also inhibited the pathological feature with follicular lining epithelial thicknesses and increased follicular colloid depositions in the thyroid glands of hypothyroidism. MOK acupuncture significantly increased hepatic GSH levels and decreased the expression of SOD and catalase in the liver, heart, and brain tissues of hyperthyroidism rats. CONCLUSIONS: These results suggest that the pharmacopuncture with MOK extract in hyperthyroidism can improve the pathophysiological changes through regulating the body temperature, thyroid hormones imbalance, lipid accumulation, and oxidation. This anti-hyperthyroidism effect of MOK pharmacopuncture is thought to be related to the control of thermo-regulating protein TRPV1 in DRG and brain.
[Mh] Termos MeSH primário: Terapia por Acupuntura/métodos
Hipertireoidismo/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
Canais de Cátion TRPV/metabolismo
[Mh] Termos MeSH secundário: Pontos de Acupuntura
Animais
Masculino
Ratos
Ratos Sprague-Dawley
Glândula Tireoide/efeitos dos fármacos
Glândula Tireoide/metabolismo
Tiroxina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (TRPV Cation Channels); 0 (Trpv1 protein, rat); Q51BO43MG4 (Thyroxine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2036-1


  5 / 19664 MEDLINE  
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[PMID]:29245333
[Au] Autor:Ji H; Yue F; Song J; Zhou X
[Ad] Endereço:aDepartment of Pharmacy, Affiliated Yancheng Hospital of Southeast University Medical CollegebDepartment of Pharmacy, Sir Runrun Hospital, Nanjing Medical UniversitycDepartment of Hepatobiliary Surgery, Affiliated Yancheng Hospital of Southeast University Medical College, Jiangsu, China.
[Ti] Título:A rare case of methimazole-induced cholestatic jaundice in an elderly man of Asian ethnicity with hyperthyroidism: A case report.
[So] Source:Medicine (Baltimore);96(49):e9093, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Methimazole is an antithyroid drug that is widely used for the treatment of hyperthyroidism. As an inhibitor of the enzyme thyroperoxidase, methimazole is generally well-tolerated. However, there have been increasing reports of methimazole-induced liver damage, although this effect of methimazole has been limited by the absence of objective diagnosis of the liver condition or the inappropriate use of the Naranjo scale. We present the case of an elderly man with hyperthyroidism, gastritis, and epilepsy who developed liver damage after administration of multiple drugs. KEY POINTS FROM THE CASE: Considering the low sensitivity of the Naranjo scale in detecting rare reactions associated with liver damage, we used the Roussel-Uclaf Causality Assessment Method scale, with a finding of cholestatic jaundice hepatitis induced by methimazole. The patient's liver enzyme levels improved after discontinuation of methimazole. MAIN LESSONS LEARNED: Our case underlines the possible hepatoxicity associated with the use of methimazole. A review of the literature confirmed a selective hepatoxicity risk in individuals of Asian ethnicity, which has not been identified in Caucasian or Black populations. Physicians should be aware of the risk of hepatoxicity when prescribing oral methimazole to patients of Asian ethnicity.
[Mh] Termos MeSH primário: Antitireóideos/efeitos adversos
Doença Hepática Induzida por Substâncias e Drogas/etiologia
Icterícia Obstrutiva/induzido quimicamente
Metimazol/efeitos adversos
[Mh] Termos MeSH secundário: Idoso
Antitireóideos/uso terapêutico
Grupo com Ancestrais do Continente Asiático
Seres Humanos
Hipertireoidismo/tratamento farmacológico
Testes de Função Hepática
Masculino
Metimazol/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antithyroid Agents); 554Z48XN5E (Methimazole)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009093


  6 / 19664 MEDLINE  
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[PMID]:29194452
[Au] Autor:Lozano-Velasco E; Wangensteen R; Quesada A; Garcia-Padilla C; Osorio JA; Ruiz-Torres MD; Aranega A; Franco D
[Ad] Endereço:Cardiac and Skeletal Muscle Development Group, Department of Experimental Biology, University of Jaen, Jaen, Spain.
[Ti] Título:Hyperthyroidism, but not hypertension, impairs PITX2 expression leading to Wnt-microRNA-ion channel remodeling.
[So] Source:PLoS One;12(12):e0188473, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PITX2 is a homeobox transcription factor involved in embryonic left/right signaling and more recently has been associated to cardiac arrhythmias. Genome wide association studies have pinpointed PITX2 as a major player underlying atrial fibrillation (AF). We have previously described that PITX2 expression is impaired in AF patients. Furthermore, distinct studies demonstrate that Pitx2 insufficiency leads to complex gene regulatory network remodeling, i.e. Wnt>microRNAs, leading to ion channel impairment and thus to arrhythmogenic events in mice. Whereas large body of evidences has been provided in recent years on PITX2 downstream signaling pathways, scarce information is available on upstream pathways influencing PITX2 in the context of AF. Multiple risk factors are associated to the onset of AF, such as e.g. hypertension (HTN), hyperthyroidism (HTD) and redox homeostasis impairment. In this study we have analyzed whether HTN, HTD and/or redox homeostasis impact on PITX2 and its downstream signaling pathways. Using rat models for spontaneous HTN (SHR) and experimentally-induced HTD we have observed that both cardiovascular risk factors lead to severe Pitx2 downregulation. Interesting HTD, but not SHR, leads to up-regulation of Wnt signaling as well as deregulation of multiple microRNAs and ion channels as previously described in Pitx2 insufficiency models. In addition, redox signaling is impaired in HTD but not SHR, in line with similar findings in atrial-specific Pitx2 deficient mice. In vitro cell culture analyses using gain- and loss-of-function strategies demonstrate that Pitx2, Zfhx3 and Wnt signaling influence redox homeostasis in cardiomyocytes. Thus, redox homeostasis seems to play a pivotal role in this setting, providing a regulatory feedback loop. Overall these data demonstrate that HTD, but not HTN, can impair Pitx2>>Wnt pathway providing thus a molecular link to AF.
[Mh] Termos MeSH primário: Proteínas de Homeodomínio/genética
Hipertensão/genética
Hipertireoidismo/genética
Canais Iônicos/metabolismo
MicroRNAs/metabolismo
Fatores de Transcrição/genética
Proteínas Wnt/metabolismo
[Mh] Termos MeSH secundário: Animais
Camundongos
Camundongos Mutantes
Ratos
Ratos Wistar
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Homeodomain Proteins); 0 (Ion Channels); 0 (MicroRNAs); 0 (Reactive Oxygen Species); 0 (Transcription Factors); 0 (Wnt Proteins); 184787-43-7 (homeobox protein PITX2)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188473


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[PMID]:28867263
[Au] Autor:Beyer C; Plank F; Friedrich G; Wildauer M; Feuchtner G
[Ad] Endereço:Innsbruck Medical University, Department of Internal Medicine III - Cardiology and Angiology, Innsbruck, Austria; Innsbruck Medical University, Department of Radiology, Innsbruck, Austria.
[Ti] Título:Effects of Hyperthyroidism on Coronary Artery Disease: A Computed Tomography Angiography Study.
[So] Source:Can J Cardiol;33(10):1327-1334, 2017 Oct.
[Is] ISSN:1916-7075
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Changes in thyroid hormone concentration can negatively affect the cardiovascular system. Subclinical hyperthyroidism has been linked to an increase of cardiovascular heart disease, however, clinical effects and significance are still uncertain. Therefore, we analyzed coronary computed tomography angiographies of patients with overt and subclinical hyperthyroidism for quantitative parameters and plaque morphology. METHODS: Seven hundred forty-four (47.1% female) patients who underwent coronary computed tomography angiography were stratified into 3 groups: 51 patients with overt, 74 patients with subclinical hyperthyroidism, and 619 patients with euthyroidism. Analysis included grades of stenosis (no stenosis = 0, mild < 50%, intermediate 50%-70%, or high-grade > 70%) and plaque types (noncalcified, mixed, and calcified), segment involvement score (SIS), noncalcified SIS, and high-risk plaque features (napkin ring sign, low attenuation plaque, spotty calcifications, positive remodelling). RESULTS: Patients with overt and subclinical hyperthyroidism had more high-grade stenoses (39.2% vs 37.8% vs 24.2%; P = 0.007) and a higher coronary calcium score (456.5 vs 199.5 vs 155.9; P < 0.0001). Also, a total higher plaque burden has been found (SIS: 3.3 vs 3.2 vs 2.2; P < 0.0001; noncalcified SIS (1.2 vs 1.1 vs 0.6; P < 0.0001)). Patients with overt hyperthyroidism, followed by those with subclinical hyperthyroidism, had the most high-risk plaque features: napkin ring (21.6% vs 9.5% vs 6.0%, P < 0.0001), low attenuation plaque (35.3% vs 27% vs 8.7%, P < 0.0001), spotty calcification (35.3% vs 18.9% vs 19.1%, P = 0.02), and positive remodelling (37.3% vs 37.8% vs 25.5%, P = 0.02). After a mean follow-up of 168 months, significantly more revascularizations were documented for hyperthyroid patients. CONCLUSIONS: Patients with subclinical and overt hyperthyroidism showed more high-grade coronary stenoses, plaque burden, and high-risk plaque features than patients with euthyroidism, which indicates that an increase of thyroid hormones might lead to coronary vascular degeneration and plaque instability.
[Mh] Termos MeSH primário: Angiografia por Tomografia Computadorizada/métodos
Angiografia Coronária/métodos
Doença da Artéria Coronariana/diagnóstico
Vasos Coronários/diagnóstico por imagem
Hipertireoidismo/complicações
[Mh] Termos MeSH secundário: Doença da Artéria Coronariana/etiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Valor Preditivo dos Testes
Estudos Retrospectivos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE


  8 / 19664 MEDLINE  
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[PMID]:28826266
[Au] Autor:McLean JL; Lobetti RG; Mooney CT; Thompson PN; Schoeman JP
[Ad] Endereço:1 Department of Companion Animal Clinical Studies, University of Pretoria, South Africa.
[Ti] Título:Prevalence of and risk factors for feline hyperthyroidism in South Africa.
[So] Source:J Feline Med Surg;19(10):1103-1109, 2017 Oct.
[Is] ISSN:1532-2750
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objectives Hyperthyroidism is a disorder of older cats that may have a geographical variation in prevalence. Prevalence studies have not yet been performed in South Africa, a geographical area where hyperthyroidism in cats has recently been observed and where, reportedly, the incidence appears to be increasing. The purpose of this study was to determine the prevalence of feline hyperthyroidism in South Africa and to identify any potential risk factors. Further information on the worldwide prevalence and possible causative factors would increase our understanding of the aetiology of this disease and help identify any preventive measures. Methods Serum total thyroxine (tT4) and canine thyroid-stimulating hormone (cTSH) were measured in 302 cats aged 9 years and older that were presented at various veterinary clinics throughout South Africa. In cats with equivocal tT4 and undetectable cTSH values, serum free thyroxine (fT4) was also measured. At the time of blood sampling a questionnaire was completed regarding vaccination history, internal and external parasite control, diet and environment. Results Prevalence of hyperthyroidism (tT4 >50 nmol/l or tT4 between 30 and 50 nmol/l with TSH <0.03 ng/ml and fT4 >50 pmol/l) was 7% (95% confidence interval 4.4-10.4), with no significant difference between healthy (5%) and sick (8%) cats. Cats ⩾12 years of age (odds ratio [OR] 4.3, P = 0.02) and cats eating canned food (OR 2.1, P = 0.1) were more likely to be diagnosed with hyperthyroidism. No significant relationship between vaccinations, parasite control or indoor environment and hyperthyroidism was observed. Hyperthyroid cats were more likely to present with weight loss (OR 3.2, P = 0.01) and with a heart rate ⩾200 beats per min (OR 5, P = 0.01) than cats without the disease. Conclusions and relevance Hyperthyroidism does not appear to be uncommon in the South African cat population. Risk factors for hyperthyroidism, specifically older age and eating canned food, were present in this as in other reported populations.
[Mh] Termos MeSH primário: Doenças do Gato/epidemiologia
Hipertireoidismo/veterinária
[Mh] Termos MeSH secundário: Fatores Etários
Animais
Gatos
Hipertireoidismo/epidemiologia
Prevalência
Fatores de Risco
África do Sul/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.1177/1098612X16684408


  9 / 19664 MEDLINE  
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[PMID]:28817835
[Au] Autor:Minlikeeva AN; Freudenheim JL; Cannioto RA; Eng KH; Szender JB; Mayor P; Etter JL; Cramer DW; Diergaarde B; Doherty JA; Dörk T; Edwards R; deFazio A; Friel G; Goodman MT; Hillemanns P; Høgdall E; Jensen A; Jordan SJ; Karlan BY; Kjær SK; Klapdor R; Matsuo K; Mizuno M; Nagle CM; Odunsi K; Paddock L; Rossing MA; Schildkraut JM; Schmalfeldt B; Segal BH; Starbuck K; Terry KL; Webb PM; Zsiros E; Ness RB; Modugno F; Bandera EV; Chang-Claude J; Moysich KB
[Ad] Endereço:Deparment of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.
[Ti] Título:History of thyroid disease and survival of ovarian cancer patients: results from the Ovarian Cancer Association Consortium, a brief report.
[So] Source:Br J Cancer;117(7):1063-1069, 2017 Sep 26.
[Is] ISSN:1532-1827
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Findings from in vitro studies suggest that increased exposure to thyroid hormones can influence progression of ovarian tumours. However, epidemiologic evidence on this topic is limited. METHODS: We pooled data from 11 studies from the Ovarian Cancer Association Consortium. Using multivariate Cox proportional hazards models, we estimated associations between hyper- and hypothyroidism and medications prescribed for these conditions with 5-year all-cause survival among women diagnosed with invasive ovarian cancer. RESULTS: Overall, there was a nonsignificant association with history of hyperthyroidism (n=160 cases) and mortality (HR=1.22; 95% CI=0.97-1.53). Furthermore, diagnosis of hyperthyroidism within the 5 years before ovarian cancer diagnosis was associated with an increased risk of death (HR=1.94; 95% CI=1.19-3.18). A more modest association was observed with history of hypothyroidism (n=624 cases) and mortality (HR=1.16; 95% CI=1.03-1.31). Neither duration of hypothyroidism nor use of thyroid medications was associated with survival. CONCLUSIONS: In this large study of women with ovarian cancer, we found that recent history of hyperthyroidism and overall history of hypothyroidism were associated with worse 5-year survival.
[Mh] Termos MeSH primário: Hipertireoidismo/epidemiologia
Hipotireoidismo/epidemiologia
Neoplasias Ovarianas/mortalidade
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Hipertireoidismo/tratamento farmacológico
Hipotireoidismo/tratamento farmacológico
Meia-Idade
Modelos de Riscos Proporcionais
Taxa de Sobrevida
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1038/bjc.2017.267


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[PMID]:28776582
[Au] Autor:Korevaar TIM; Medici M; Visser TJ; Peeters RP
[Ad] Endereço:Department of Internal Medicine, Erasmus Medical Center, Postbus 2040, 3000 CA, Rotterdam, The Netherlands.
[Ti] Título:Thyroid disease in pregnancy: new insights in diagnosis and clinical management.
[So] Source:Nat Rev Endocrinol;13(10):610-622, 2017 Oct.
[Is] ISSN:1759-5037
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Adequate thyroid hormone availability is important for an uncomplicated pregnancy and optimal fetal growth and development. Overt thyroid disease is associated with a wide range of adverse obstetric and child development outcomes. An increasing number of studies now indicate that milder forms of thyroid dysfunction are also associated with these adverse pregnancy outcomes. The definitions of both overt and subclinical thyroid dysfunction have changed considerably over the past few years, as new data indicate that the commonly used fixed upper limits of 2.5 mU/l or 3.0 mU/l for thyroid-stimulating hormone (TSH) are too low to define an abnormal thyroid function. Furthermore, some studies now show that the reference ranges are not necessarily the best cut-off for identifying pregnancies at high risk of adverse outcomes. In addition, data suggest that thyroid peroxidase autoantibody positivity and high or low concentrations of human chorionic gonadotropin seem to have a more prominent role in the interpretation of thyroid dysfunction than previously thought. Data on the effects of thyroid disease treatment are lacking, but some studies indicate that clinicians should be aware of the potential for overtreatment with levothyroxine. Here, we put studies from the past decade on reference ranges for TSH, determinants of thyroid dysfunction, risks of adverse outcomes and options for treatment into perspective. In addition, we provide an overview of the current views on thyroid physiology during pregnancy and discuss strategies to identify high-risk individuals who might benefit from levothyroxine treatment.
[Mh] Termos MeSH primário: Complicações na Gravidez/diagnóstico
Resultado da Gravidez
Doenças da Glândula Tireoide/diagnóstico
Doenças da Glândula Tireoide/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Feminino
Idade Gestacional
Seres Humanos
Hipertireoidismo/diagnóstico
Hipertireoidismo/tratamento farmacológico
Hipotireoidismo/diagnóstico
Hipotireoidismo/tratamento farmacológico
Gravidez
Complicações na Gravidez/tratamento farmacológico
Diagnóstico Pré-Natal/métodos
Ensaios Clínicos Controlados Aleatórios como Assunto
Testes de Função Tireóidea
Hormônios Tireóideos/uso terapêutico
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Thyroid Hormones)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE
[do] DOI:10.1038/nrendo.2017.93



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