Base de dados : MEDLINE
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  1 / 32109 MEDLINE  
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[PMID]:29274211
[Au] Autor:Jakubas-Zawalska J; Asman M; Solarz K
[Ad] Endereço:Department of Parasitology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, ul. Jednosci 8, 41-218 Sosnowiec, Poland
[Ti] Título:Sensitization to the storage mites Lepidoglyphus destructor and Tyrophagus putrescentiae (Acari, Sarcoptiformes, Astigmatina) in a suburban population in Southern Poland
[So] Source:Ann Parasitol;63(3):183-188, 2017.
[Is] ISSN:2299-0631
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Mite infestation of stored products is a serious threat to food safety and public health. These stored product mites are not only serious pests of stored food but also cause allergies in humans. Thirty serum samples from patients living in suburban areas of Upper Silesia (South Poland) were tested for sensitization to two species of storage mites: Lepidoglyphus destructor [LD] and Tyrophagus putrescentiae [TP]. Patient antibodies against particular antigens were identified using anti-human anti-IgE monoclonal antibodies. Fifteen protein fractions from LD gave positive reactions with IgE antibodies and 18 from TP. Seven of the 30 samples showed positive reactions to a protein fraction measuring about 29 kDa from LD and six reacted with a fraction measuring about 25 kDa from TP. These findings may imply the existence of many protein fractions with allergenic properties besides the characterized allergens in the two tested species.
[Mh] Termos MeSH primário: Hipersensibilidade/epidemiologia
Hipersensibilidade/imunologia
Ácaros/imunologia
[Mh] Termos MeSH secundário: Alérgenos/imunologia
Alérgenos/metabolismo
Animais
Feminino
Seres Humanos
Masculino
Ácaros/metabolismo
Polônia/epidemiologia
População Suburbana
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE
[do] DOI:10.17420/ap6303.104


  2 / 32109 MEDLINE  
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[PMID]:28449757
[Au] Autor:Brignardello-Petersen R
[Ti] Título:No evidence of an association between an allergy to dental materials and dental hygiene products and symptomatic oral lesions.
[So] Source:J Am Dent Assoc;148(5):e53, 2017 05.
[Is] ISSN:1943-4723
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Materiais Dentários
Higiene Bucal
[Mh] Termos MeSH secundário: Seres Humanos
Hipersensibilidade
Úlceras Orais
[Pt] Tipo de publicação:REVIEW; COMMENT
[Nm] Nome de substância:
0 (Dental Materials)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  3 / 32109 MEDLINE  
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[PMID]:29424990
[Au] Autor:Loskutov DV; Khamitova RY
[Ti] Título:[The genetic component of chronic respiratory diseases in workers of foundry productions].
[So] Source:Gig Sanit;95(7):623-6, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Review of the literature shows that currently there is an accumulation of data on the genetic determination of individual susceptibility to adverse industrial factors. Material of the research were high molecular DNA samples isolated from epithelial mouth scrapings in 99 foundry workers. Study of polymorphic variants of interleukin genes was performed by means of the analysis ofproducts of amplification of specific regions of the genome. Homozygous genotype TNF-a (-308A/G) was established to increase the relative risk of shaping of chronic respiratory diseases: with AA alleles - by 6.4 times and GG alleles - by 2.4 times, while the heterozygous genotype (AG) decreases - by 1. 9 times. Polymorphism of gene IL-1ß (+3953 T / C) had no significance for the development of respiratory disease. Genotyping interleukins, involved in the inflammatory responses of the bronchopulmonary tract, can be considered as an element ofprimary prevention in industries with a high risk for shaping of respiratory diseases.
[Mh] Termos MeSH primário: Metalurgia
Doenças Profissionais
Doenças Respiratórias
Fator de Necrose Tumoral alfa/genética
[Mh] Termos MeSH secundário: Adulto
Predisposição Genética para Doença
Seres Humanos
Hipersensibilidade/genética
Interleucina-1beta/genética
Masculino
Doenças Profissionais/epidemiologia
Doenças Profissionais/etiologia
Doenças Profissionais/genética
Polimorfismo Genético
Doenças Respiratórias/epidemiologia
Doenças Respiratórias/etiologia
Doenças Respiratórias/genética
Federação Russa/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (IL1B protein, human); 0 (Interleukin-1beta); 0 (Tumor Necrosis Factor-alpha)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE


  4 / 32109 MEDLINE  
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[PMID]:28468955
[Au] Autor:Kaminuma O; Katayama K; Inoue K; Saeki M; Nishimura T; Kitamura N; Shimo Y; Tofukuji S; Ishida S; Ogonuki N; Kamimura S; Oikawa M; Katoh S; Mori A; Shichijo M; Hiroi T; Ogura A
[Ad] Endereço:Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan osamuk@yamanashi.ac.jp ogura@rtc.riken.go.jp.
[Ti] Título:Hyper-reactive cloned mice generated by direct nuclear transfer of antigen-specific CD4 T cells.
[So] Source:EMBO Rep;18(6):885-893, 2017 Jun.
[Is] ISSN:1469-3178
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:T-cell receptor (TCR)-transgenic mice have been employed for evaluating antigen-response mechanisms, but their non-endogenous TCR might induce immune response differently than the physiologically expressed TCR Nuclear transfer cloning produces animals that retain the donor genotype in all tissues including germline and immune systems. Taking advantage of this feature, we generated cloned mice that carry endogenously rearranged TCR genes from antigen-specific CD4 T cells. We show that T cells of the cloned mice display distinct developmental pattern and antigen reactivity because of their endogenously pre-rearranged TCRα (rTα) and TCRß (rTß) alleles. These alleles were transmitted to the offspring, allowing us to establish a set of mouse lines that show chronic-type allergic phenotypes, that is, bronchial and nasal inflammation, upon local administrations of the corresponding antigens. Intriguingly, the existence of either rTα or rTß is sufficient to induce hypersensitivity. These cloned mice expressing intrinsic promoter-regulated antigen-specific TCR are a unique animal model with allergic predisposition for investigating CD4 T-cell-mediated pathogenesis and cellular commitment in immune diseases.
[Mh] Termos MeSH primário: Linfócitos T CD4-Positivos/imunologia
Hipersensibilidade/imunologia
Técnicas de Transferência Nuclear
Receptores de Antígenos de Linfócitos T/genética
[Mh] Termos MeSH secundário: Alelos
Animais
Antígenos/administração & dosagem
Antígenos/imunologia
Clonagem de Organismos
Modelos Animais de Doenças
Camundongos
Camundongos Transgênicos
Receptores de Antígenos de Linfócitos T/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens); 0 (Receptors, Antigen, T-Cell)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.15252/embr.201643321


  5 / 32109 MEDLINE  
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[PMID]:29325306
[Au] Autor:Xing B; Lin JT; Tang HP; Yang L; Yuan YD; Gu YH; Chen P; Liu XJ; Zhang J; Liu HG; Wang CZ; Zhou W; Sun DJ; Chen YQ; Chen ZC; Huang M; Lin QC; Hu CP; Yang XH; Huo JM; Ye XW; Zhou X; Jiang P; Zhang W; Huang YJ; Dai LM; Liu RY; Cai SX; Xu JY; Zhou JY
[Ti] Título:[A retrospective study of the inducing factors and clinical characteristics of patients hospitalized for asthma exacerbation in China in 2013-2014].
[So] Source:Zhonghua Nei Ke Za Zhi;57(1):21-26, 2018 Jan 01.
[Is] ISSN:0578-1426
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To study the inducing factors and clinical characteristics of patients hospitalized for asthma exacerbation in China. Patients hospitalized for asthma exacerbation at 29 hospitals in China were retrospectively recruited during 2013-2014. Clinical data of 3 240 asthmatic patients were collected and analyzed including 1 369(42.3%) males and 1 871(57.7%) females. The patients hospitalized for asthma exacerbation counted for 2.95% (6 375/215 955) of all patients hospitalized during the same period. The leading six inducing factors, in sequence, were acute upper respiratory tract infection [42.3%(1 370/3 240)], changes of weather [22.8%(738/3 240)], noxious gas [(4.3%(140/3 240), allergy challenges [3.5%(115/3 240)], strenuous exercise [1.8%(57/3 240)], and air pollution [1.5%(49/3 240)]. In older patients, more exacerbations were induced by weather changes, yet less sensitive to allergy challenges. As to middle-aged patients, they were less sensitive to upper respiratory tract infections, however the difference was not statistically significant ( >0.05). In winter more asthma patients were induced by upper respiratory tract infections, while in autumn more patients were induced by weather changes, strenuous exercise and air pollution. In spring and summer more patients were induced by allergy challenges, but the differences failed to achieve statistical significance ( >0.05). In northern cities more patients were induced by upper respiratory infections, whereas in southern cities more by noxious gases. Allergy challenges and air pollution tended to affect more patients in northern cities, but the difference was of no significance ( >0.05). The differences of inducing factors among patients of different gender, with or without a smoking history, and with different exacerbation severity didn't show any statistical significance. The patients with severe and life-threatening exacerbations counted for 20.1% (652/3 240). The percentage of patients older than 60 years was higher in patients with severe or life-threatening exacerbations than in whose with mild or moderate exacerbations, so did the percentage of male patients, of patients with disease duration longer than 10 years, with smoking history, and with a history of hospitalization or emergency department visits due to asthma exacerbation during the last year. The acute upper respiratory tract infection ranks top among all the inducing factors. Senility, male gender, long duration of disease, smoking history, and a history of frequent hospital visits might be the risk factors for severe or life-threatening asthma exacerbations.
[Mh] Termos MeSH primário: Antiasmáticos/uso terapêutico
Asma/tratamento farmacológico
Hospitalização
Infecções Respiratórias/complicações
[Mh] Termos MeSH secundário: Poluição do Ar/efeitos adversos
Antiasmáticos/administração & dosagem
Asma/diagnóstico
Asma/epidemiologia
Asma/etiologia
China/epidemiologia
Feminino
Seres Humanos
Hipersensibilidade
Masculino
Meia-Idade
Infecções Respiratórias/epidemiologia
Estudos Retrospectivos
Fatores de Risco
Estações do Ano
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Asthmatic Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0578-1426.2018.01.004


  6 / 32109 MEDLINE  
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[PMID]:29363738
[Au] Autor:Willen SM; Rodeghier M; Strunk RC; Bacharier LB; Rosen CL; Kirkham FJ; DeBaun MR; Cohen RT
[Ad] Endereço:Department of Pediatrics, Division of Hematology/Oncology, Vanderbilt-Meharry Center for Excellence in Sickle Cell Disease, Vanderbilt University Medical Center, Nashville, TN, USA.
[Ti] Título:Aeroallergen sensitization predicts acute chest syndrome in children with sickle cell anaemia.
[So] Source:Br J Haematol;180(4):571-577, 2018 02.
[Is] ISSN:1365-2141
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Asthma is associated with higher rates of acute chest syndrome (ACS) and vaso-occlusive pain episodes among children with sickle cell anaemia (SCA). Aeroallergen sensitization is a risk factor for asthma. We hypothesized that aeroallergen sensitization is associated with an increased incidence of hospitalizations for ACS and pain. Participants in a multicentre, longitudinal cohort study, aged 4-18 years with SCA, underwent skin prick testing to ten aeroallergens. ACS and pain episodes were collected from birth until the end of the follow-up period. The number of positive skin tests were tested for associations with prospective rates of ACS and pain. Multivariable models demonstrated additive effects of having positive skin tests on future rates of ACS (incidence rate ratio (IRR) for each positive test 1·23, 95% confidence interval [CI] 1·11-1·36, P < 0·001). Aeroallergen sensitization was not associated with future pain (IRR 1·14, 95%CI 0·97-1·33, P = 0·11). Our study demonstrated that children with SCA and aeroallergen sensitization are at increased risk for future ACS. Future research is needed to determine whether identification of specific sensitizations and allergen avoidance and treatment reduce the risk of ACS for children with SCA.
[Mh] Termos MeSH primário: Síndrome Torácica Aguda/diagnóstico
Síndrome Torácica Aguda/etiologia
Alérgenos/imunologia
Anemia Falciforme/complicações
[Mh] Termos MeSH secundário: Adolescente
Aerossóis
Biomarcadores
Criança
Pré-Escolar
Feminino
Seguimentos
Seres Humanos
Hipersensibilidade/complicações
Hipersensibilidade/imunologia
Imunização
Masculino
Morbidade
Medição da Dor
Prognóstico
Estudos Prospectivos
Testes Cutâneos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Aerosols); 0 (Allergens); 0 (Biomarkers)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1111/bjh.15076


  7 / 32109 MEDLINE  
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[PMID]:29308841
[Au] Autor:Namazova-Barahona LS; Snovskaya MA; Mitushin IL; Kozhevnikova OV; Batyrova AS
[Ti] Título:Peculiarities of Allergy Diagnosis in Children.
[So] Source:Vestn Ross Akad Med Nauk;72(1):33-41, 2017.
[Is] ISSN:0869-6047
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:Allergic disease is a serious problem in practical healthcare. Over the last 40 years there has been exponential growth in the prevalence. According to the world health organization information, allergic diseases are at the 2nd place in prevalence the children, behind the viral infections. Their frequency and severity are increasing. In this regard, the relevance of timely and skilled diagnostic allergopathology is most important. In this study the current state of the question of allergy diagnostics is considered, the international experience is summarized and the approach to the allergy diagnosis based on use of step-by-step identification of a causal and significant factor of allergic reactions is offered. On the basis of the analysis of relevance and the importance for patients of one or the other allergens (taking into account a source of allergens and age of patients) use of a step-by-step allergy diagnostics algorithm is offered. The first step is definition of clinical implications of an allergy. It means direct contact of the phisition with the patient, clarification of its complaints, clinical symptoms, medical history disease. The second step is the confirmation of IgE-dependent mechanism. It involves the using of screening tests that are selected depending on the clinical symptoms and seasonality manifestations (the screening module). The third step is to identify the source of the allergens that are most meaningful for the patient with using test panels (modules). The panels include the most common and clinically relevant triggers of allergic reactions. The fourth step is the search for an individual significant allergens, which were not included in the diagnostic modules. On the fifth step, we plan to conduct component-divided diagnostics and detect the antibodies to unique components of significant allergens. The developed diagnostics algorithm, corresponds to needs of both the adult, and children's population and provides the personalized approach to the patients.
[Mh] Termos MeSH primário: Hipersensibilidade
Pediatria/métodos
[Mh] Termos MeSH secundário: Algoritmos
Alérgenos/análise
Criança
Seres Humanos
Hipersensibilidade/diagnóstico
Hipersensibilidade/imunologia
Imunoglobulina E/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Allergens); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180109
[St] Status:MEDLINE
[do] DOI:10.15690/vramn799


  8 / 32109 MEDLINE  
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[PMID]:28462523
[Au] Autor:Zheng L; Li J; Lenardo M
[Ad] Endereço:Laboratory of Immunology and Clinical Genomics Program, Molecular Development of the Immune System Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
[Ti] Título:Restimulation-induced cell death: new medical and research perspectives.
[So] Source:Immunol Rev;277(1):44-60, 2017 05.
[Is] ISSN:1600-065X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the periphery, homeostasis of the immune system depends on the equilibrium of expanding and contracting T lymphocytes during immune response. An important mechanism of lymphocyte contraction is clonal depletion of activated T cells by cytokine withdrawal induced death (CWID) and TCR restimulation induced cell death (RICD). Deficiencies in signaling components for CWID and RICD leads to autoimmunune lymphoproliferative disorders in mouse and human. The most important feature of CWID and RICD is clonal specificity, which lends great appeal as a strategy for targeted tolerance induction and treatment of autoimmune diseases, allergic disorders, and graft rejection by depleting undesired disease-causing T cells while keeping the overall host immunity intact.
[Mh] Termos MeSH primário: Doenças Autoimunes/imunologia
Rejeição de Enxerto/imunologia
Hipersensibilidade/imunologia
Transtornos Linfoproliferativos/imunologia
Linfócitos T/imunologia
[Mh] Termos MeSH secundário: Animais
Morte Celular
Deleção Clonal
Seleção Clonal Mediada por Antígeno
Citocinas/metabolismo
Homeostase
Seres Humanos
Imunização
Camundongos
Tolerância Periférica
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., INTRAMURAL
[Nm] Nome de substância:
0 (Cytokines)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1111/imr.12535


  9 / 32109 MEDLINE  
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[PMID]:28454489
[Au] Autor:Ren J; Ni H; Kim M; Cooley KL; Valenzuela RM; Asche CV
[Ad] Endereço:a Center for Outcomes Research , University of Illinois College of Medicine at Peoria , Peoria , Illinois , USA.
[Ti] Título:Allergies, antibiotics use, and multiple sclerosis.
[So] Source:Curr Med Res Opin;33(8):1451-1456, 2017 Aug.
[Is] ISSN:1473-4877
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The associations between allergies, antibiotics use, and multiple sclerosis (MS) remain controversial and their mediating or moderating effects have not yet been examined. We aimed to assess the direct and indirect influences of allergies and antibiotics use on MS development, and their interactions. METHODS: A 1:3 matched case-control study was performed using the National Ambulatory Medical Care Survey database from 2006 to 2013 in the USA. Multiple sclerosis was identified based on the ICD-9 code (340.0) in any position. Cases were matched to their controls based on survey year, age, gender, race, payer type, region, and tobacco use. Allergy diseases and antibiotics prescriptions were extracted by ICD-9 code and drug classification code, respectively. Both generalized structural equation model and MacArthur approach were used to examine their intrinsic relationships. RESULTS: The weighted prevalence of MS was 133.7 per 100,000 visits. A total of 829 MS patients and 2441 controls were matched. Both respiratory tract allergies (OR = 0.29, 95% CI: 0.18, 0.49) and other allergies (OR = 0.38, 95% CI: 0.19, 0.77) were associated with a reduction of the risk of MS. Patients with respiratory tract allergies were more likely to use penicillin (OR = 8.73, 95% CI: 4.12, 18.53) and other antibiotics (OR = 3.77, 95% CI: 2.72, 5.21), and those with other allergies had a higher likelihood of penicillin use (OR = 4.15, 95% CI: 1.27, 13.54); however, the link between antibiotics use and MS was not confirmed although penicillin use might mediate the relationship between allergies and MS. CONCLUSIONS: The findings supported allergy as a protective factor for MS development. We also suggest antibiotics use might not be a suitable indicator of bacterial infection to investigate the cause of MS.
[Mh] Termos MeSH primário: Antibacterianos/administração & dosagem
Hipersensibilidade/epidemiologia
Esclerose Múltipla/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Estudos de Casos e Controles
Bases de Dados Factuais
Feminino
Seres Humanos
Masculino
Meia-Idade
Esclerose Múltipla/etiologia
Penicilinas/administração & dosagem
Prevalência
Fatores de Proteção
Risco
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Penicillins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1080/03007995.2017.1325575


  10 / 32109 MEDLINE  
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[PMID]:29322776
[Au] Autor:Zhao Y; Zhang J; Chen Y; Li Z; Nie H; Peng W; Su S
[Ad] Endereço:College of Bee Sciences/College of Life Sciences, Fujian Agriculture and Forestry University , Fuzhou, Fujian 350002, People's Republic of China.
[Ti] Título:Altered Serum Metabolite Profiling and Relevant Pathway Analysis in Rats Stimulated by Honeybee Venom: New Insight into Allergy to Honeybee Venom.
[So] Source:J Agric Food Chem;66(4):871-880, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To improve our understanding of the disturbed metabolic pathways and cellular responses triggered by honeybee venom stimulation, we compared the changes in serum metabolites in rats, either stimulated or not by honeybee venom, by performing H nuclear magnetic resonance (NMR) spectrometry-based metabonomics to identify potential biomarkers. In this study, 65 metabolites were structurally confirmed and quantified and the following results were obtained. First, by pattern recognition analysis, 14 metabolites were selected as potential biomarkers 3 h after venom stimulation. Second, metabolic pathway analysis showed that methane metabolism, glyoxylate and dicarboxylate metabolism, tricarboxylic acid cycle, glycine, serine, and threonine metabolism, arginine and proline metabolism were affected. Finally, the time-dependent metabolic modifications indicated that rats could recover without medical treatment 24 h after venom stimulation. In summary, this new insight into the changes in serum metabolites in rats after honeybee venom stimulation has enhanced our understanding of the response of an organism to honeybee venom.
[Mh] Termos MeSH primário: Venenos de Abelha/imunologia
Venenos de Abelha/farmacologia
Hipersensibilidade/sangue
Metabolômica/métodos
[Mh] Termos MeSH secundário: Animais
Biomarcadores/sangue
Espectroscopia de Ressonância Magnética
Masculino
Metaboloma
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bee Venoms); 0 (Biomarkers)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04160



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