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  1 / 18372 MEDLINE  
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[PMID]:29460640
[Au] Autor:Sullivan A; Watkinson J; Waddington J; Park BK; Naisbitt DJ
[Ad] Endereço:a MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology , The University of Liverpool , Liverpool , England.
[Ti] Título:Implications of HLA-allele associations for the study of type IV drug hypersensitivity reactions.
[So] Source:Expert Opin Drug Metab Toxicol;14(3):261-274, 2018 Mar.
[Is] ISSN:1744-7607
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Type IV drug hypersensitivity remains an important clinical problem and an obstacle to the development of new drugs. Several forms of drug hypersensitivity are associated with expression of specific HLA alleles. Furthermore, drug-specific T-lymphocytes have been isolated from patients with reactions. Despite this, controversy remains as to how drugs interact with immune receptors to stimulate a T-cell response. Areas covered: This article reviews the pathways of T-cell activation by drugs and how the ever increasing number of associations between expression of HLA alleles and susceptibility to hypersensitivity is impacting on our research effort to understanding this form of iatrogenic disease. Expert opinion: For a drug to activate a T-cell, a complex is formed between HLA molecules, an HLA binding peptide, the drug and the T-cell receptor. T-cell responses can involve drugs and stable or reactive metabolites bound covalently or non-covalently to any component of this complex. Recent research has linked the HLA associations to the disease through the characterization of drug-specific T-cell responses restricted to specific alleles. However, there is now a need to identify the additional genetic or environment factors that determine susceptibility and use our increased knowledge to develop predictive immunogenicity tests that offer benefit to Pharma developing new drugs.
[Mh] Termos MeSH primário: Hipersensibilidade a Drogas/imunologia
Antígenos HLA/imunologia
Hipersensibilidade Tardia/induzido quimicamente
[Mh] Termos MeSH secundário: Alelos
Hipersensibilidade a Drogas/genética
Predisposição Genética para Doença
Seres Humanos
Hipersensibilidade Tardia/genética
Hipersensibilidade Tardia/imunologia
Ativação Linfocitária/efeitos dos fármacos
Ativação Linfocitária/imunologia
Linfócitos T/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (HLA Antigens)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180221
[St] Status:MEDLINE
[do] DOI:10.1080/17425255.2018.1441285


  2 / 18372 MEDLINE  
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[PMID]:29281719
[Au] Autor:Druszczynska M; Wlodarczyk M; Kielnierowski G; Seweryn M; Wawrocki S; Rudnicka W
[Ad] Endereço:Division of Cell Immunology, Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland.
[Ti] Título:CD14-159C/T polymorphism in the development of delayed skin hypersensitivity to tuberculin.
[So] Source:PLoS One;12(12):e0190106, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The skin tuberculin test (TST), an example of a delayed-type hypersensitivity (DTH) reaction, is based on measuring the extent of skin induration to mycobacterial tuberculin (PPD). Little is known about the genetic basis of TST reactivity, widely used for diagnosing TB infection. The study investigated the relationship of the single base change polymorphic variants in CD14 gene (CD14(-159C/T)) with the development of DTH to PPD in BCG-vaccinated Polish Caucasian individuals. We found persistent lack of TST reactivity in about 40% of healthy subjects despite receiving more than one dose of BCG. The TST size was negatively correlated with the number of BCG inoculations. The distribution of C/T genotype was significantly more frequent among TST-negative compared with TST-positive individuals. The concentration of serum sCD14 was positively associated with mCD14 expression, but not with the TST status or CD14(-159C/T) polymorphism. A significant increase in mCD14 expression and serum sCD14 levels was found in TB group. We hypothesize that CD14(-159C/T) polymorphic variants might be one of genetic components in the response to attenuated M. bovis BCG bacilli.
[Mh] Termos MeSH primário: Hipersensibilidade Tardia
Receptores de Lipopolissacarídeos/imunologia
Polimorfismo Genético
Tuberculina/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Teste Tuberculínico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Lipopolysaccharide Receptors); 0 (Tuberculin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190106


  3 / 18372 MEDLINE  
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[PMID]:29193267
[Au] Autor:Speziali EF; Menezes JS; Santiago AF; Vaz NM; Faria AMC
[Ad] Endereço:Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
[Ti] Título:Lifelong Maintenance of Oral Tolerance and Immunity Profiles in Mice Depends on Early Exposure to Antigen.
[So] Source:Scand J Immunol;87(2):73-79, 2018 Feb.
[Is] ISSN:1365-3083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Oral tolerance is defined as a state of systemic hyporesponsiveness to an antigen that has been previously administered by the oral route. Many factors affect oral tolerance induction; some of them related to antigen, and some related to the animal. The age of the animal is one of the most important factors that affect oral tolerance as ageing brings many alterations in immune responses. Herein, we demonstrated that both the oral tolerance and pattern of immune reactivity triggered in early life were kept up to 15 months regarding the magnitude of antibody production, cell proliferation and cytokine profile when compared to immune responses induced in old mice. Therefore, our results corroborate with a promising proposal for prevaccination during childhood and young age, and a booster in older age, to make sure that the primary immunization in early life is not lost in aged individuals.
[Mh] Termos MeSH primário: Antígenos/imunologia
Hipersensibilidade Tardia/imunologia
Tolerância Imunológica
[Mh] Termos MeSH secundário: Administração Oral
Animais
Proliferação Celular
Células Cultivadas
Citocinas/metabolismo
Exposição Ambiental
Feminino
Seres Humanos
Imunidade Humoral
Imunização
Ativação Linfocitária
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Endogâmicos DBA
Vacinas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens); 0 (Cytokines); 0 (Vaccines)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1111/sji.12635


  4 / 18372 MEDLINE  
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[PMID]:29337673
[Au] Autor:Abu-Rish EY; Elhayek SY; Mohamed YS; Hamad I; Bustanji Y
[Ad] Endereço:1Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy The University of Jordan, Amman 11942, Jordan.
[Ti] Título:Evaluation of immunomodulatory effects of lamotrigine in BALB/c mice.
[So] Source:Acta Pharm;67(4):543-555, 2017 Dec 20.
[Is] ISSN:1846-9558
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:Modulation of the immune system has recently been shown to be involved in the pharmacological effects of old antiepileptic drugs and in the pathogenesis of epilepsy. Therefore, the most recent guidelines for immunotoxicological evaluation of drugs were consulted to investigate the immunomodulatory effects of lamotrigine, a newer antiepileptic drug, in BALB/c mice. These included the in vivo effects of lamotrigine on delayed-type hypersensitivity (DTH) response to sheep red blood cell (SRBC) antigens, hemagglutination titer assays and hematological changes. In vitro effects of lamotrigine on ConA-induced splenocyte proliferation and cytokine secretion were assessed. The results showed that lamotrigine treatment significantly increased the DTH response to SRBC in the mouse model of this study. This was accompanied by a significant increase in relative monocyte and neutrophil counts and in spleen cellularity. Lamotrigine significantly inhibited ConA-induced splenocyte proliferation in vitro and it significantly inhibited IL-2 and TNF-α secretion in ConA-stimulated splenocytes. In conclusion, the results demonstrated significant immunomodulatory effects of lamotrigine in BALB/c mice. These data could expand the understanding of lamotrigine-induced adverse reactions and its role in modulating the immune system in epilepsy.
[Mh] Termos MeSH primário: Imunomodulação/efeitos dos fármacos
Triazinas/farmacologia
[Mh] Termos MeSH secundário: Animais
Anticonvulsivantes/farmacologia
Proliferação Celular/efeitos dos fármacos
Concanavalina A/farmacologia
Citocinas/metabolismo
Feminino
Hipersensibilidade Tardia/tratamento farmacológico
Camundongos
Camundongos Endogâmicos BALB C/imunologia
Baço/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticonvulsants); 0 (Cytokines); 0 (Triazines); 11028-71-0 (Concanavalin A); U3H27498KS (lamotrigine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE


  5 / 18372 MEDLINE  
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[PMID]:28981507
[Au] Autor:Krolewiecki AJ; Almazan MC; Quipildor M; Juarez M; Gil JF; Espinosa M; Canabire M; Cajal SP
[Ad] Endereço:Instituto de Investigaciones en Enfermedades Tropicales, Universidad Nacional de Salta/CONICET, Oran, Argentina.
[Ti] Título:Reappraisal of Leishmanin Skin Test (LST) in the management of American Cutaneous Leishmaniasis: A retrospective analysis from a reference center in Argentina.
[So] Source:PLoS Negl Trop Dis;11(10):e0005980, 2017 Oct.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Leishmania (Viannia) braziliensis is the species most frequently implicated with cutaneous and mucosal leishmaniasis in the Americas; its diagnosis is based on the identification of amastigotes in lesions, which is limited by low parasite burden. Leishmanin Skin Test (LST) is a support tool for diagnosis, based on delayed type hypersensitivity responses to Leishmania antigens injected intradermally, used in endemic areas as a complement to diagnosis. A retrospective analysis of individuals evaluated for their first episode of tegumentary leishmaniasis at a reference center in Argentina during the period 2006-2015 was performed, with the goal of assessing its usefulness as a support tool in the diagnosis of leishmaniasis. Demographic, clinical and diagnostic work-up were analyzed in individuals with clinically compatible lesions, lesion`s smear and LST. A total of 733 cases that met the case definition were included in the analysis; 678 (93%) localized cutaneous cases, 50 (7%) with mucosal involvement and 5 (<1%) disseminated. Diagnostic confirmation was reached in 474 (65%) cases through positive smears from skin or mucosal lesions, with only 6 cases among this group having negative LST. Among smear negative cases, 190 were negative also by LST, but in 69 instances LST was positive. Across age groups, similar ratios of sensitivity between smear and LST were calculated. Lesions older than 21 days-old were found to correlate with positive results both for smear and LST significantly more than younger lesions. These findings support the clinical use of LST as a diagnostic complement for American Cutaneous Leishmaniasis across all age groups even in endemic areas. In this analysis, the correlation with smear was high. Standardization of this technique and further research into its most adequate preparation and utilization protocols across different sites will help in the management of suspicious clinical cases.
[Mh] Termos MeSH primário: Leishmaniose Cutânea/diagnóstico
Leishmaniose Cutânea/parasitologia
Testes Cutâneos
Pele/imunologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Antígenos de Protozoários/imunologia
Argentina/epidemiologia
Criança
Pré-Escolar
Gerenciamento Clínico
Feminino
Seres Humanos
Hipersensibilidade Tardia
Lactente
Recém-Nascido
Leishmania braziliensis/imunologia
Leishmania braziliensis/isolamento & purificação
Leishmaniose Cutânea/epidemiologia
Leishmaniose Cutânea/imunologia
Masculino
Meia-Idade
Estudos Retrospectivos
Pele/parasitologia
Pele/patologia
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Protozoan); 0 (leishmanin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005980


  6 / 18372 MEDLINE  
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[PMID]:28963929
[Au] Autor:Rostamian M; Niknam HM
[Ad] Endereço:Immunology Department, Pasteur Institute of Iran, Tehran, 13164, Iran.
[Ti] Título:Evaluation of the adjuvant effect of agonists of toll-like receptor 4 and 7/8 in a vaccine against leishmaniasis in BALB/c mice.
[So] Source:Mol Immunol;91:202-208, 2017 11.
[Is] ISSN:1872-9142
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:There is no effective vaccine against human leishmaniasis. Achieving successful vaccines seems to need powerful adjuvants. Separate or combined use of toll like receptor (TLR) agonists as adjuvant is a promising approach in Leishmania vaccine research. In present study, we evaluated adjuvant effect of separate or combined use of a TLR7/8 agonist, R848 and a TLR4 agonist, monophosphoryl lipid A (MPL) beside soluble Leishmania antigen (SLA) in BALB/c mice. Mice were vaccinated three times by SLA with separate or combined TLR7/8 and TLR4 agonists and were then challenged by Leishmania major. Delay type hypersensitivity, lesion development, parasite load, and cytokines (interferon gamma, and interleukin-10) response were assessed. Results showed: 1) MPL can slightly assist SLA in parasite load reduction, but it is not able to increase SLA ability in evoking DTH and cytokine responses or decreasing lesion diameter. 2) R848 does not affect the DTH response and parasite load of mice vaccinated with SLA, but it decreases/inhibits cytokine responses induced by SLA, leading to increase lesion diameter. 3) MPL neutralized inhibitory effect of R848. In overall, these data emphasize that MPL slightly assists SLA to make a more potent vaccine, but R848 is not a good adjuvant to induce T cell-dependent immune response in BALB/c mice, and therefore combination of these TLR agonists in the current formulation, is not recommended for making a more powerful adjuvant.
[Mh] Termos MeSH primário: Adjuvantes Imunológicos/farmacologia
Imidazóis/farmacologia
Leishmania major/imunologia
Vacinas contra Leishmaniose/farmacologia
Leishmaniose Cutânea/prevenção & controle
Lipídeo A/análogos & derivados
Glicoproteínas de Membrana/agonistas
Receptor 4 Toll-Like/agonistas
Receptor 7 Toll-Like/agonistas
Receptor 8 Toll-Like/agonistas
[Mh] Termos MeSH secundário: Animais
Antígenos de Protozoários/imunologia
Antígenos de Protozoários/farmacologia
Hipersensibilidade Tardia/imunologia
Hipersensibilidade Tardia/patologia
Imidazóis/imunologia
Interferon gama/imunologia
Interleucina-10/imunologia
Vacinas contra Leishmaniose/imunologia
Leishmaniose Cutânea/imunologia
Leishmaniose Cutânea/patologia
Lipídeo A/imunologia
Lipídeo A/farmacologia
Glicoproteínas de Membrana/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Receptor 4 Toll-Like/imunologia
Receptor 7 Toll-Like/imunologia
Receptor 8 Toll-Like/imunologia
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adjuvants, Immunologic); 0 (Antigens, Protozoan); 0 (IFNG protein, mouse); 0 (IL10 protein, mouse); 0 (Imidazoles); 0 (Leishmaniasis Vaccines); 0 (Lipid A); 0 (Membrane Glycoproteins); 0 (TLR8 protein, mouse); 0 (Tlr4 protein, mouse); 0 (Tlr7 protein, mouse); 0 (Toll-Like Receptor 4); 0 (Toll-Like Receptor 7); 0 (Toll-Like Receptor 8); 130068-27-8 (Interleukin-10); 82115-62-6 (Interferon-gamma); MWC0ET1L2P (monophosphoryl lipid A); V3DMU7PVXF (resiquimod)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171001
[St] Status:MEDLINE


  7 / 18372 MEDLINE  
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[PMID]:28732198
[Au] Autor:Bone AJ; Houck KA
[Ad] Endereço:National Center for Computational Toxicology, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
[Ti] Título:Primary Cell Phenotypic Screening Illuminates ADRs and AOPs.
[So] Source:Cell Chem Biol;24(7):781-782, 2017 07 20.
[Is] ISSN:2451-9456
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Preclinical, in vitro screening for adverse drug reactions continues to present challenges in the field of drug development. In this issue of Cell Chemical Biology, Shah et al. (2017) employ a phenotypic screening strategy using a panel of human primary cells to define a signature response and an adverse outcome pathway for delayed type IV skin hypersensitivity.
[Mh] Termos MeSH primário: Hipersensibilidade a Drogas
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
[Mh] Termos MeSH secundário: Sistemas de Notificação de Reações Adversas a Medicamentos
Avaliação Pré-Clínica de Medicamentos
Seres Humanos
Hipersensibilidade Tardia
Preparações Farmacêuticas
Prevenção Primária
Estudos Prospectivos
Pele
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Nm] Nome de substância:
0 (Pharmaceutical Preparations)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE


  8 / 18372 MEDLINE  
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[PMID]:28709944
[Au] Autor:Bezerra CF; Mota ÉF; Silva ACM; Tomé AR; Silva MZR; de Brito D; Porfírio CTMN; Oliveira AC; Lima-Filho JV; Ramos MV
[Ad] Endereço:Instituto Federal de Educação, Ciência e Tecnologia do Estado do Rio Grande do Norte, Pau dos Ferros, Rio Grande do Norte, Brazil. Electronic address: bfmila@yahoo.com.br.
[Ti] Título:Latex proteins from Calotropis procera: Toxicity and immunological tolerance revisited.
[So] Source:Chem Biol Interact;274:138-149, 2017 Aug 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Many thousands of plants are disseminated worldwide in traditional and folk medicines based on the belief that their leaves, roots, seeds, bark or secretions, when adequately handled, can treat, alleviate or ameliorate numerous disease symptoms. Calotropis procera (Apocynaceae) is a popular medicinal plant and the claims of this shrub's phytomedicinal properties have been scientifically validated. In this study, further prospects towards the in vivo toxicity and oral immunological tolerance of phytomodulatory proteins isolated from the latex of C. procera are reported. Acute toxicity was determined in mice by oral and intraperitoneal administration of latex proteins (LP) and was followed behavioral, hematological and histological analyses. Oral immunological tolerance to LP was assessed by intraperitoneal immunization in mice that had received LP orally before. Animals given 5000 mg/kg orally exhibited only discrete behavioral alterations and augmentation of monocytes. Death was not notified 14 days after exposure. However, all animals receiving LP 150 mg/kg by i.p. died in 1 h. Death (20%) was documented when LP (75 mg/kg) was given in the peritoneum and signs of harmful effects were observed in the survivors (80%). Oral immunological tolerance was observed in animals previously given LP orally, when they were further immunized/challenged with peritoneal exposure to different doses of LP. This was confirmed by the lowering of IgE and IgG in the serum, IL-4 and IFN-γ in spleen homogenates and the absence of anaphylaxis signs. It is therefore concluded that LP exhibited quite discrete adverse effects when orally administrated at higher concentrations and this route of administration did not stimulate adverse immunological reactions. Instead it was observed immunological tolerance. The present study contributes very important information concerning the safe use of C. procera as a phytotherapeutic agent.
[Mh] Termos MeSH primário: Calotropis/metabolismo
Tolerância Imunológica/efeitos dos fármacos
Látex/toxicidade
Proteínas de Plantas/toxicidade
[Mh] Termos MeSH secundário: Administração Oral
Anafilaxia/etiologia
Animais
Feminino
Hipersensibilidade Tardia/etiologia
Imunoglobulina E/sangue
Imunoglobulina G/sangue
Infusões Parenterais
Interferon gama
Interleucina-4/metabolismo
Rim/efeitos dos fármacos
Rim/patologia
Látex/imunologia
Látex/metabolismo
Camundongos
Proteínas de Plantas/imunologia
Plantas Medicinais/metabolismo
Baço/efeitos dos fármacos
Baço/metabolismo
Baço/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G); 0 (Latex); 0 (Plant Proteins); 207137-56-2 (Interleukin-4); 37341-29-0 (Immunoglobulin E); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170716
[St] Status:MEDLINE


  9 / 18372 MEDLINE  
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[PMID]:28419151
[Au] Autor:Glennie ND; Volk SW; Scott P
[Ad] Endereço:Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
[Ti] Título:Skin-resident CD4+ T cells protect against Leishmania major by recruiting and activating inflammatory monocytes.
[So] Source:PLoS Pathog;13(4):e1006349, 2017 Apr.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tissue-resident memory T cells are required for establishing protective immunity against a variety of different pathogens, although the mechanisms mediating protection by CD4+ resident memory T cells are still being defined. In this study we addressed this issue with a population of protective skin-resident, IFNγ-producing CD4+ memory T cells generated following Leishmania major infection. We previously found that resident memory T cells recruit circulating effector T cells to enhance immunity. Here we show that resident memory CD4+ T cells mediate the delayed-hypersensitivity response observed in immune mice and provide protection without circulating T cells. This protection occurs rapidly after challenge, and requires the recruitment and activation of inflammatory monocytes, which limit parasites by production of both reactive oxygen species and nitric oxide. Overall, these data highlight a novel role for tissue-resident memory cells in recruiting and activating inflammatory monocytes, and underscore the central role that skin-resident T cells play in immunity to cutaneous leishmaniasis.
[Mh] Termos MeSH primário: Linfócitos T CD4-Positivos/imunologia
Leishmania major/imunologia
Leishmaniose Cutânea/imunologia
Monócitos/imunologia
[Mh] Termos MeSH secundário: Animais
Linfócitos T CD4-Positivos/parasitologia
Hipersensibilidade Tardia
Imunidade Celular
Memória Imunológica
Leishmaniose Cutânea/parasitologia
Camundongos
Camundongos Endogâmicos C57BL
Monócitos/parasitologia
Óxido Nítrico/metabolismo
Parabiose
Espécies Reativas de Oxigênio/metabolismo
Pele/imunologia
Pele/parasitologia
Organismos Livres de Patógenos Específicos
Transplantes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Reactive Oxygen Species); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006349


  10 / 18372 MEDLINE  
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[PMID]:28398203
[Au] Autor:Gonzalez-Cavero L; Dominguez-Ortega J; Gonzalez-Muñoz M; Mayor-Ibarguren A; Tomás M; Fiandor A; Quirce S
[Ad] Endereço:Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.
[Ti] Título:Delayed Allergic Reaction to Terbinafine With a Positive Lymphocyte Transformation Test.
[So] Source:J Investig Allergol Clin Immunol;27(2):136-137, 2017.
[Is] ISSN:1018-9068
[Cp] País de publicação:Spain
[La] Idioma:eng
[Mh] Termos MeSH primário: Antifúngicos/efeitos adversos
Proliferação Celular/efeitos dos fármacos
Hipersensibilidade a Drogas/etiologia
Hipersensibilidade Tardia/induzido quimicamente
Ativação Linfocitária/efeitos dos fármacos
Linfócitos/efeitos dos fármacos
Naftalenos/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Células Cultivadas
Hipersensibilidade a Drogas/diagnóstico
Hipersensibilidade a Drogas/imunologia
Feminino
Seres Humanos
Hipersensibilidade Tardia/diagnóstico
Hipersensibilidade Tardia/imunologia
Testes Intradérmicos
Linfócitos/imunologia
Testes do Emplastro
Valor Preditivo dos Testes
Fatores de Tempo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Naphthalenes); G7RIW8S0XP (terbinafine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.18176/jiaci.0133



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