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[PMID]:28470742
[Au] Autor:Lee DD; Muskaj I; Savage W
[Ad] Endereço:Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
[Ti] Título:Platelet proteins cause basophil histamine release through an immunoglobulin-dependent mechanism.
[So] Source:Transfusion;57(7):1709-1716, 2017 07.
[Is] ISSN:1537-2995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: A general understanding of allergic transfusion reaction mechanisms remains elusive. Multiple mechanisms have been proposed, but none have been compared experimentally. STUDY DESIGN AND METHODS: We used histamine release (HR) from healthy human donor basophils to model allergic transfusion reactions. Platelet component supernatant (plasma), platelet lysate, and manipulated platelet lysates (dialyzed, delipidated, trypsinized, mild heat-inactivated, and ultracentrifuged) were used to characterize allergic stimuli. Immunoglobulin-dependent mechanisms were investigated through cell surface immunoglobulin depletion and ibrutinib signaling inhibition. HR induced by platelet mitochondria was compared with HR by platelet lysate with or without DNase treatment. RESULTS: Robust, dose-responsive HR to platelet lysate was observed in two of eight nulliparous, never-transfused, healthy donors. No HR was observed with plasma. Among manipulated platelet lysates, only trypsin treatment significantly reduced HR (39% reduction; p = 0.008). HR in response to platelet lysate significantly decreased with either cell surface immunoglobulin depletion or ibrutinib pretreatment. Platelet mitochondria induced minimal basophil HR, and DNase treatment did not inhibit platelet lysate-induced HR. CONCLUSION: Type I immediate hypersensitivity to platelet proteins may be an allergic transfusion reaction mechanism. Prior sensitization to human proteins is not required for basophil responses to platelet proteins. Further study into the relative contributions of hypersensitivity to platelet versus plasma proteins in transfusion is warranted.
[Mh] Termos MeSH primário: Basófilos/fisiologia
Plaquetas/imunologia
Proteínas Sanguíneas/imunologia
Liberação de Histamina
Hipersensibilidade Imediata/etiologia
Imunoglobulina E/imunologia
Reação Transfusional/etiologia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Proteins); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1111/trf.14126


  2 / 11953 MEDLINE  
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[PMID]:29211772
[Au] Autor:Spierenburg EAJ; Smit LAM; Krop EJM; Heederik D; Hylkema MN; Wouters IM
[Ad] Endereço:Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Utrecht, the Netherlands.
[Ti] Título:Occupational endotoxin exposure in association with atopic sensitization and respiratory health in adults: Results of a 5-year follow-up.
[So] Source:PLoS One;12(12):e0189097, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objective of the present longitudinal study was to investigate the effects of occupational endotoxin exposure on respiratory health and atopic sensitization in adults. Health outcomes and personal endotoxin exposure estimates were determined for 234 farmers and agricultural workers both at baseline and 5 years later. A questionnaire was used to assess respiratory symptoms, spirometry tests were performed and total and specific IgE levels were measured in serum. A twofold increase in personal endotoxin exposure was associated with less hay fever (OR 0.68, 95%CI 0.54-0.87) and grass IgE positivity (OR 0.81, 95%CI 0.68-0.97) at both time points ("persistent" versus "never"). Although not statistically significant, a consistent protective pattern was observed for an increased loss of hay fever symptoms (OR 2.19, 95%CI 0.96-4.99) and grass IgE positivity (OR 1.24, 95%CI 0.76-2.02), and for less new-onset of hay fever (OR 0.87, 95%CI 0.65-1.17), grass IgE positivity (OR 0.83, 95%CI 0.61-1.12) and atopic sensitization (OR 0.75, 95%CI 0.55-1.02). Endotoxin exposure was not associated with changes in lung function. We showed that occupational endotoxin exposure is associated with a long-term protective effect on hay fever and grass IgE positivity. Results on longitudinal changes in hay fever, atopy and grass IgE positivity in adulthood were consistent with a protective effect of endotoxin exposure, but results need to be confirmed in larger cohorts. An effect of endotoxin exposure on lung function decline was not found.
[Mh] Termos MeSH primário: Endotoxinas/administração & dosagem
Hipersensibilidade Imediata
Exposição Ocupacional
Sistema Respiratório/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adulto
Estudos de Coortes
Feminino
Seguimentos
Seres Humanos
Imunoglobulina E/sangue
Masculino
Meia-Idade
Testes de Função Respiratória
Sistema Respiratório/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Endotoxins); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189097


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[PMID]:27775867
[Au] Autor:Fischer J; Eberlein B; Hilger C; Eyer F; Eyerich S; Ollert M; Biedermann T
[Ad] Endereço:Department of Dermatology, Faculty of Medicine, Eberhard Karls University Tuebingen, Tuebingen, Germany.
[Ti] Título:Alpha-gal is a possible target of IgE-mediated reactivity to antivenom.
[So] Source:Allergy;72(5):764-771, 2017 May.
[Is] ISSN:1398-9995
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Antivenoms are mammalian immunoglobulins with the ability to neutralize snake venom components and to mitigate the progression of toxic effects. Immediate hypersensitivity to antivenoms often occurs during the first administration of these heterologous antibodies. A comparable clinical situation occurred after introduction of cetuximab, a chimeric mouse-human antibody, for cancer treatment. The carbohydrate epitope galactose-alpha-1,3-galactose, located on the Fab region of cetuximab, was identified as the target responsible for IgE reactivity. OBJECTIVE: To investigate whether serum IgE antibodies directed to the α-gal epitope are associated with hypersensitivity to equine antivenoms. METHODS: Antivenoms were screened for α-gal epitopes via immunoblot and in comparison with cetuximab and pork kidney by IgE reactivity assays. Basophil activation tests were used to investigate reactivity to antivenoms in samples from 20 patients with specific IgE antibodies to α-gal and 10 controls. Additional IgE detection, IgE inhibition, ImmunoCAP inhibition, and skin prick tests were performed using samples from selected patients. RESULTS: Both antivenoms and cetuximab induced positive skin prick test results in patients with sIgE to α-gal. Alpha-gal epitopes were detected by immunoblotting on antivenoms. Measurements of IgE reactivity and ImmunoCAP inhibition indicated that the antivenoms contained lower α-gal contents than cetuximab. Deglycosylation assays and IgE inhibition tests confirmed that IgE-mediated reactivity to antivenom is associated with α-gal. Antivenoms, pork kidney, and cetuximab activated basophils from patients with IgE to α-gal. CONCLUSION: Alpha-gal is a potential target of IgE-mediated reactivity to equine antivenom and a possible cause of the high incidence of hypersensitivity reactions during the first application of equine antivenom.
[Mh] Termos MeSH primário: Antivenenos/imunologia
Hipersensibilidade Imediata/imunologia
Imunoglobulina E/imunologia
alfa-Galactosidase/imunologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Animais
Basófilos/imunologia
Basófilos/metabolismo
Biomarcadores
Cetuximab/efeitos adversos
Relação Dose-Resposta Imunológica
Epitopos/imunologia
Feminino
Cavalos
Seres Humanos
Hipersensibilidade Imediata/diagnóstico
Hipersensibilidade Imediata/metabolismo
Masculino
Meia-Idade
Testes Cutâneos
Tetraspanina 30/metabolismo
Tireoglobulina/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antivenins); 0 (Biomarkers); 0 (Epitopes); 0 (Tetraspanin 30); 37341-29-0 (Immunoglobulin E); 9010-34-8 (Thyroglobulin); EC 3.2.1.22 (alpha-Galactosidase); PQX0D8J21J (Cetuximab)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171207
[Lr] Data última revisão:
171207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1111/all.13073


  4 / 11953 MEDLINE  
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[PMID]:27775836
[Au] Autor:Del Giacco SR; Bakirtas A; Bel E; Custovic A; Diamant Z; Hamelmann E; Heffler E; Kalayci Ö; Saglani S; Sergejeva S; Seys S; Simpson A; Bjermer L
[Ad] Endereço:Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
[Ti] Título:Allergy in severe asthma.
[So] Source:Allergy;72(2):207-220, 2017 Feb.
[Is] ISSN:1398-9995
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:It is well recognized that atopic sensitization is an important risk factor for asthma, both in adults and in children. However, the role of allergy in severe asthma is still under debate. The term 'Severe Asthma' encompasses a highly heterogeneous group of patients who require treatment on steps 4-5 of GINA guidelines to prevent their asthma from becoming 'uncontrolled', or whose disease remains 'uncontrolled' despite this therapy. Epidemiological studies on emergency room visits and hospital admissions for asthma suggest the important role of allergy in asthma exacerbations. In addition, allergic asthma in childhood is often associated with severe asthma in adulthood. A strong association exists between asthma exacerbations and respiratory viral infections, and interaction between viruses and allergy further increases the risk of asthma exacerbations. Furthermore, fungal allergy has been shown to play an important role in severe asthma. Other contributing factors include smoking, pollution and work-related exposures. The 'Allergy and Asthma Severity' EAACI Task Force examined the current evidence and produced this position document on the role of allergy in severe asthma.
[Mh] Termos MeSH primário: Alérgenos/imunologia
Asma/diagnóstico
Asma/etiologia
Hipersensibilidade/imunologia
[Mh] Termos MeSH secundário: Fatores Etários
Idade de Início
Animais
Asma/epidemiologia
Diagnóstico Diferencial
Exposição Ambiental
Seres Humanos
Hipersensibilidade/complicações
Hipersensibilidade/epidemiologia
Hipersensibilidade/etiologia
Hipersensibilidade Imediata/complicações
Hipersensibilidade Imediata/imunologia
Imunoglobulina E/sangue
Imunoglobulina E/imunologia
Exposição por Inalação
Fenótipo
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Allergens); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171207
[Lr] Data última revisão:
171207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE
[do] DOI:10.1111/all.13072


  5 / 11953 MEDLINE  
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[PMID]:27778417
[Au] Autor:Martins C; Lima J; Nunes G; Borrego LM
[Ad] Endereço:CEDOC, Chronic Diseases Research Center, Immunology, NOVA Medical School|FCM, Universidade Nova de Lisboa, Lisbon, Portugal.
[Ti] Título:Pregnancy alters the circulating B cell compartment in atopic asthmatic women, and transitional B cells are positively associated with the development of allergy manifestations in their progeny.
[So] Source:Am J Reprod Immunol;76(6):465-474, 2016 Dec.
[Is] ISSN:1600-0897
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:PROBLEM: Maternal atopy is a risk factor for allergy. B cells are poorly studied in reproduction and atopy. We aimed to assess how pregnancy affects B cells in atopic women and whether B cells relate to allergic manifestations in offspring. METHOD OF STUDY: Women with and without atopic asthma, pregnant and non-pregnant were enrolled for the study, and circulating B cells were evaluated by flow cytometry, using CD19, CD27, CD38, IgD, and IgM. RESULTS: Compared to healthy non-pregnant, atopic asthmatic non-pregnant (ANP) women presented increased B cell counts, enlarged memory subsets, less transitional cells, and plasmablasts. Atopic asthmatic pregnant (AP) and healthy pregnant (HP) women showed similarities: reduced B cell counts and percentages, fewer memory cells, especially switched, and higher plasmablast percentages. Transitional B cell percentages were increased in AP women with allergic manifestations in their progeny. CONCLUSION: Atopic asthmatic non-pregnant women have a distinctive B cell compartment. B cells change in pregnancy, similarly in AP and HP women. The recognition that AP women with allergy in their progeny have a typical immune profile may help, in the future, the adoption of preventive measures to avoid the manifestation of allergic diseases in their newborns.
[Mh] Termos MeSH primário: Asma/imunologia
Linfócitos B/imunologia
Hipersensibilidade Imediata/imunologia
Memória Imunológica
Herança Materna/imunologia
[Mh] Termos MeSH secundário: ADP-Ribosil Ciclase 1/genética
ADP-Ribosil Ciclase 1/imunologia
Adulto
Antígenos CD19/genética
Antígenos CD19/imunologia
Asma/diagnóstico
Asma/genética
Asma/patologia
Linfócitos B/patologia
Estudos de Casos e Controles
Feminino
Expressão Gênica
Seres Humanos
Hipersensibilidade Imediata/diagnóstico
Hipersensibilidade Imediata/genética
Hipersensibilidade Imediata/patologia
Imunoglobulina D/sangue
Imunoglobulina M/sangue
Imunofenotipagem
Recém-Nascido
Doenças do Recém-Nascido
Contagem de Linfócitos
Glicoproteínas de Membrana/genética
Glicoproteínas de Membrana/imunologia
Gravidez
Membro 7 da Superfamília de Receptores de Fatores de Necrose Tumoral/genética
Membro 7 da Superfamília de Receptores de Fatores de Necrose Tumoral/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD19); 0 (CD19 molecule, human); 0 (Immunoglobulin D); 0 (Immunoglobulin M); 0 (Membrane Glycoproteins); 0 (Tumor Necrosis Factor Receptor Superfamily, Member 7); EC 3.2.2.5 (CD38 protein, human); EC 3.2.2.6 (ADP-ribosyl Cyclase 1)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171130
[Lr] Data última revisão:
171130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1111/aji.12595


  6 / 11953 MEDLINE  
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[PMID]:28890022
[Au] Autor:Scott-Taylor TH; Axinia SC; Strobel S
[Ad] Endereço:Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom. Electronic address: t.scott-taylor@londonmet.ac.uk.
[Ti] Título:Lymphoproliferative responses to dendritic cell presentation of sensitizing allergens in atopic children with multiple allergies.
[So] Source:Ann Allergy Asthma Immunol;119(3):274-283, 2017 Sep.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Peripheral blood mononuclear cells (PBMCs) proliferate inconsistently, rendering current lymphoproliferation assays unreliable in diagnosis. OBJECTIVE: To investigate the utility and nature of proliferation responses in allergy by comparison of the standard lymphoproliferation with a new dendritic cell (DC) stimulated assay. METHODS: Monocyte-derived DCs were pulsed with allergens and incubated with autologous T cells for 7 days. DC-stimulated and standard PBMC proliferation responses to 3 common dietary allergens in children with allergy and without atopy were measured by incorporation of tritiated thymidine and reduction of carboxyl fluorescein succinimidyl ester staining. RESULTS: The DC presentation of sensitizing allergens induced significantly higher proliferative responses than PBMC stimulation (P = .04) and greater distinction between normal and allergic responses. DC-induced stimulation indices of children without sensitivity and those with allergy were significantly different with all 3 foods (P < .001). All children with allergy presented with peanut allergy and 12 of 14 (86%) ß-lactoglobulin-pulsed DC preparations proliferated more than 3.3-fold above un-pulsed cells, but 8 of 18 children (44%) with ovalbumin egg allergy showed proliferation below this level. The stimulation index of DC tritiated thymidine incorporation correlated closely with carboxyl fluorescein succinimidyl ester reduction (P < .001). Sensitivity of detection of peanut, milk, or egg allergy was 100%, 85.7%, or 55.6% and specificity was 60%, 88.9%, or 86.7%, respectively. DC-stimulated T cells expressed increased levels of CD45 RO and CD25 and most produced interferon-γ. DC-stimulated proliferation correlated with total immunoglobulin E and peanut antigen-stimulated proliferation correlated with peanut specific immunoglobulin E (P = .03). CONCLUSION: The DC-induced lymphoproliferation had higher sensitivity, specificity, and reproducibility than the standard assay and caused increased memory and activated T-cell proliferation in children with food allergy.
[Mh] Termos MeSH primário: Alérgenos/imunologia
Células Dendríticas/imunologia
Hipersensibilidade Imediata/imunologia
Linfócitos T/imunologia
[Mh] Termos MeSH secundário: Adolescente
Animais
Apresentação do Antígeno
Arachis/imunologia
Proliferação Celular
Criança
Pré-Escolar
Feminino
Seres Humanos
Hipersensibilidade Imediata/sangue
Imunoglobulina E/sangue
Imunoglobulina E/imunologia
Leucócitos Mononucleares/imunologia
Masculino
Leite/imunologia
Ovalbumina/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 37341-29-0 (Immunoglobulin E); 9006-59-1 (Ovalbumin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170912
[St] Status:MEDLINE


  7 / 11953 MEDLINE  
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[PMID]:28686638
[Au] Autor:Savi E; Incorvaia C; Boni E; Mauro M; Peveri S; Pravettoni V; Quercia O; Reccardini F; Montagni M; Pessina L; Ridolo E
[Ad] Endereço:Allergy Dept. Unit, G. Da Saliceto Hospital, AUSL, Piacenza, Italy.
[Ti] Título:Which immunotherapy product is better for patients allergic to Polistes venom? A laboratory and clinical study.
[So] Source:PLoS One;12(7):e0180270, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Venom immunotherapy (VIT) is highly effective in preventing allergic reactions to insect stings, but the appropriate venom must be used to achieve clinical protection. In patients with multiple positive results to venoms, molecular allergy diagnostics or CAP-inhibition may identify the causative venom. Concerning allergy to venom from Polistes spp. it has been proposed that only the European species P. dominulus should be used for VIT. However, this recommendation is not present in any international guideline. Using both laboratory and clinical data, we aimed to evaluate the reliability of this proposal. METHODS: We performed an in vitro study using CAP-inhibition to determine sensitization of 19 patients allergic to Polistes venom. The clinical study included 191 patients with positive tests to Polistes treated with VIT, 102 were treated with P. dominulus and 89 were treated with a mix of American Polistes (mAP). RESULTS: The difference in % of inhibition was significant concerning inhibition of P. dominulus sIgE by P. dominulus venom (79.8%) compared with inhibition by mAP venom (64.2%) and not significant concerning the inhibition of mAP sIgE by P. dominulus venom (80.1%) and by mAP venom (73.6%). Instead, the clinical protection from stings was not statistically different between the two kinds of venom. CONCLUSION: The data from CAP inhibition would suggest that the choice of either P. dominulus venom or mAP venom for VIT is appropriate in patients with CAP inhibition higher than 70%, but the clinical data show the same odds of protection from stings using for VIT P. dominulus or mAP venom.
[Mh] Termos MeSH primário: Alérgenos/administração & dosagem
Dessensibilização Imunológica/métodos
Hipersensibilidade Imediata/terapia
Mordeduras e Picadas de Insetos/terapia
Venenos de Vespas/administração & dosagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Alérgenos/química
Alérgenos/imunologia
Animais
Europa (Continente)
Seres Humanos
Hipersensibilidade Imediata/imunologia
Hipersensibilidade Imediata/fisiopatologia
Imunoglobulina E/sangue
Mordeduras e Picadas de Insetos/imunologia
Mordeduras e Picadas de Insetos/fisiopatologia
Meia-Idade
Especificidade da Espécie
Estados Unidos
Venenos de Vespas/química
Venenos de Vespas/imunologia
Vespas/química
Vespas/imunologia
[Pt] Tipo de publicação:CLINICAL STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Wasp Venoms); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180270


  8 / 11953 MEDLINE  
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Barreto, Mauricio L
Texto completo
[PMID]:28668455
[Au] Autor:Fiuza BSD; Silva MJ; Alcântara-Neves NM; Barreto ML; Costa RDS; Figueiredo CA
[Ad] Endereço:Departamento de Biorregulação, Laboratório de Imunofarmacologia e Biologia Molecular, Universidade Federal da Bahia (ICS), Bahia, Brazil.
[Ti] Título:Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children.
[So] Source:Mol Immunol;90:33-41, 2017 Oct.
[Is] ISSN:1872-9142
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Asthma is a heterogeneous disease associated with a complex basis involving environmental factors and individual variabilities. The DENN Domain Containing 1B (DENND1B) gene has an important role on T cell receptor (TCR) down-regulation on Th2 cells and studies have shown that mutations or loss of this factor can be associated with increased Th2 responses and asthma. The aim of this work is to evaluate the association of polymorphisms in the DENND1B with asthma and allergy markers phenotypes in Brazilian children. Genotyping was performed using a commercial panel from Illumina (2.5 Human Omni bead chip) in 1309 participants of SCAALA (Social Change, Asthma, Allergy in Latin American) program. Logistic regressions for asthma and atopy markers were performed using PLINK software 1.9. The analyzes were adjusted for sex, age, helminth infections and ancestry markers. The DENND1B gene was associated with different phenotypes such as severe asthma and atopic markers (specific IgE production, skin prick test and IL-13 production). Among the 166 SNPs analyzed, 72 were associated with asthma and/or allergy markers. In conclusion, polymorphisms in the DENND1B are significantly associated with development of asthma and atopy and these polymorphisms can influence DENND1B expression and consequently, asthma.
[Mh] Termos MeSH primário: Asma/genética
Proteínas Adaptadoras de Sinalização de Receptores de Domínio de Morte/genética
Predisposição Genética para Doença
Fatores de Troca do Nucleotídeo Guanina/genética
Hipersensibilidade Imediata/genética
[Mh] Termos MeSH secundário: Adolescente
Asma/imunologia
Brasil
Criança
Pré-Escolar
Citocinas/biossíntese
Feminino
Estudos de Associação Genética
Seres Humanos
Hipersensibilidade Imediata/imunologia
Imunoglobulina E/sangue
Masculino
Polimorfismo de Nucleotídeo Único/genética
Inquéritos e Questionários
Células Th2/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (DENND1B protein, human); 0 (Death Domain Receptor Signaling Adaptor Proteins); 0 (Guanine Nucleotide Exchange Factors); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170703
[St] Status:MEDLINE


  9 / 11953 MEDLINE  
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[PMID]:28668105
[Au] Autor:Bellanti JA; Settipane RA
[Ti] Título:The atopic disorders and atopy … "strange diseases" now better defined!
[So] Source:Allergy Asthma Proc;38(4):241-242, 2017 07 01.
[Is] ISSN:1539-6304
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Dermatite Atópica
Hipersensibilidade Imediata
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170703
[St] Status:MEDLINE
[do] DOI:10.2500/aap.2017.38.4074


  10 / 11953 MEDLINE  
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[PMID]:28656655
[Au] Autor:Yasui K; Matsuyama N; Okamura-Shiki I; Ikeda T; Ishii K; Furuta RA; Hirayama F
[Ad] Endereço:Japanese Red Cross Kinki Block Blood Center, Osaka, Japan.
[Ti] Título:Clinical utility of a passive immune basophil activation test for the analysis of allergic transfusion reactions.
[So] Source:Transfusion;57(9):2084-2095, 2017 Sep.
[Is] ISSN:1537-2995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In previous studies, we demonstrated that the basophil activation test, which is performed using patient blood and the supernatants from transfused blood components, was able to elucidate not only the causative relationship between allergic transfusion reactions and the transfusion but also the mechanisms behind allergic transfusion reactions. However, for a large number of allergic transfusion reactions, patients are in a state of myelosuppression, and the basophil activation test cannot be performed for these patients because there are insufficient numbers of peripheral blood basophils. STUDY DESIGN AND METHODS: To overcome this obstacle, we developed a passive immune basophil activation test, in which patient plasma and residually transfused blood are used as the patient's sources of immunoglobulin E and allergen, respectively, whereas healthy volunteer basophils serve as the responder cell source. The passive immune basophil activation test was performed for two patients who had severe allergic transfusion reactions, using supernatants of the residual platelet concentrates and the patients' own immunoglobulin E. RESULTS: There were no differences in either surface immunoglobulin E or activation in response to allergens between untreated basophils and so-called quasi-basophils, in which immunoglobulin E was replaced by a third party's immunoglobulin E. In these patients, the supernatants of the residual platelet concentrates exclusively activated basophils in response to quasi-basophils onto which the patients' immunoglobulin E, but not a third party's immunoglobulin E, was bound. CONCLUSION: The passive immune basophil activation test may help clarify the causal relationship between allergic transfusion reactions and transfused blood, even when patients experience myelosuppression.
[Mh] Termos MeSH primário: Basófilos/imunologia
Plaquetas/imunologia
Hipersensibilidade Imediata/prevenção & controle
Reação Transfusional
Reação Transfusional/imunologia
[Mh] Termos MeSH secundário: Alérgenos/sangue
Basófilos/citologia
Seres Humanos
Hipersensibilidade Imediata/imunologia
Imunoglobulina E
Reação Transfusional/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE
[do] DOI:10.1111/trf.14208



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