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Pesquisa : C20.543.480.370 [Categoria DeCS]
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  1 / 13644 MEDLINE  
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[PMID]:29489655
[Au] Autor:Liu X; Hong X; Tsai HJ; Mestan KK; Shi M; Kefi A; Hao K; Chen Q; Wang G; Caruso D; Geng H; Gao Y; He J; Kumar R; Wang H; Yu Y; Bartell T; Tan XD; Schleimer RP; Weeks DE; Pongracic JA; Wang X
[Ad] Endereço:Key Laboratory of Genomic and Precision Medicine, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
[Ti] Título:Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy.
[So] Source:Medicine (Baltimore);97(9):e0043, 2018 Mar.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Previous genetic studies of food allergy (FA) have mainly focused on inherited genotypic effects. The role of parental genotypic effects remains largely unexplored. Leveraging existing genome-wide association study (GWAS) data generated from the Chicago Food Allergy Study, we examined maternal genotypic and parent-of-origin (PO) effects using multinomial likelihood ratio tests in 588 complete and incomplete Caucasian FA trios. We identified 1 single nucleotide polymorphism with significant (P < 5×10) maternal effect on any FA (rs4235235), which is located in a noncoding RNA (LOC101927947) with unknown function. We also identified 3 suggestive (P < 5×10) loci with maternal genetic effects: 1 for any FA (rs976078, in a gene desert region on 13q31.1) and 2 for egg allergy (rs1343795 and rs4572450, in the ZNF652 gene, where genetic variants have been associated with atopic dermatitis). Three suggestive loci with PO effect were observed: 1 for peanut allergy (rs4896888 in the ADGB gene) and 2 for any FA in boys only (rs1036504 and rs2917750 in the IQCE gene). Findings from this family-based GWAS of FA provided some preliminary evidence on maternal genotypic or PO effects on FA. Additional family-based studies are needed to confirm our findings and gain new insight into maternal and paternal genetic contribution to FA.
[Mh] Termos MeSH primário: Hipersensibilidade Alimentar/genética
Estudo de Associação Genômica Ampla
Impressão Genômica
[Mh] Termos MeSH secundário: Pai
Feminino
Genótipo
Seres Humanos
Masculino
Mães
Polimorfismo de Nucleotídeo Único
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180301
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000010043


  2 / 13644 MEDLINE  
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[PMID]:29370173
[Au] Autor:Benedé S; Berin MC
[Ad] Endereço:Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
[Ti] Título:Mast cell heterogeneity underlies different manifestations of food allergy in mice.
[So] Source:PLoS One;13(1):e0190453, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Food can trigger a diverse array of symptoms in food allergic individuals from isolated local symptoms affecting skin or gut to multi-system severe reactions (systemic anaphylaxis). Although we know that gastrointestinal and systemic manifestations of food allergy are mediated by tissue mast cells (MCs), it is not clear why allergen exposure by the oral route can result in such distinct clinical manifestations. Our aim was to assess the contribution of mast cell subsets to different manifestations of food allergy. We used two common models of IgE-mediated food allergy, one resulting in systemic anaphylaxis and the other resulting in acute gastrointestinal symptoms, to study the immune basis of allergic reactions. We used responders and non-responders in each model system, as well as naïve controls to identify the association of mast cell activation with clinical reactivity rather than sensitization. Systemic anaphylaxis was uniquely associated with activation of connective tissue mast cells (identified by release of mouse mast cell protease (MMCP) -7 into the serum) and release of histamine, while activation of mucosal mast cells (identified by release of MMCP-1 in the serum) did not correlate with symptoms. Gastrointestinal manifestations of food allergy were associated with an increase of MMCP-1-expressing mast cells in the intestine, and evidence of both mucosal and connective tissue mast cell activation. The data presented in this paper demonstrates that mast cell heterogeneity is an important contributor to manifestations of food allergy, and identifies the connective tissue mast cell subset as key in the development of severe systemic anaphylaxis.
[Mh] Termos MeSH primário: Hipersensibilidade Alimentar/imunologia
Mastócitos/imunologia
[Mh] Termos MeSH secundário: Animais
Trato Gastrointestinal/imunologia
Liberação de Histamina
Técnicas Imunoenzimáticas
Mastócitos/enzimologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C3H
Reação em Cadeia da Polimerase em Tempo Real
Triptases/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
EC 3.4.21.59 (Tpsab1 protein, mouse); EC 3.4.21.59 (Tryptases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190453


  3 / 13644 MEDLINE  
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[PMID]:29429507
[Au] Autor:Léauté-Labrèze C
[Ad] Endereço:Unité de dermatologie pédiatrique et centre de référence des maladies rares de la peau, hôpital Pellegrin-Enfants, CHU de Bordeaux, 33076 Bordeaux Cedex, France. Electronic address: christine.labreze@chu-bordeaux.fr.
[Ti] Título:[What's new in pediatric dermatology?]
[Ti] Título:Quoi de neuf en dermatologie pédiatrique ?.
[So] Source:Ann Dermatol Venereol;143 Suppl 3:S29-S36, 2016 Dec.
[Is] ISSN:0151-9638
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:The association of a birth defect and a segmental hemangioma is well established, a consensus concerning evaluation and monitoring of infants with PHACE or LUMBAR syndromes has been published. The efficacy of propranolol in infantile hemangioma is proven; however there were still unresolved issues concerning the safety in children; after 8 years of use on thousands of children safety data collection did not show any unexpected side effects. Topical treatment of infantile hemangiomas with beta-blockers, such as timolol, is very popular, but recent publications revealed a significant systemic absorption that could be responsible for severe side effects, such as bradycardia, in low birthweight infants. As a consequence, this therapeutic option should be considered with caution. In the last 2 years mTOR inhibitors have been tested in low-flow vascular malformations with varying success, but progress remains to be done in the treatment of vascular abnormalities. Today, genetics has led to advances in the understanding of the pathophysiology and in the future targeted therapies could probably be feasible. Skin barrier deficiency is responsible for the development of allergic phenomena in atopic patients, since it has been shown that sensibilisation, even to food, could probably be induced by skin contact. Unfortunately, the topical treatment with crisaborole, a phosphodiesterase 4 inhibitor, does not look like a revolution in children atopic dermatitis, its efficacy seems equivalent to emollient application. In the field of infectious diseases, changes in viral outbreaks are the most reported. Furthermore epidemic Zika virus, enteroviruses are responsible for expanded dermatological manifestations and also severe meningoencephalitis. Paraviral character of various eruptions, such as gloves and socks syndrome or eruptive pseudoangiomatosis is challenged.
[Mh] Termos MeSH primário: Dermatopatias
[Mh] Termos MeSH secundário: Coartação Aórtica/terapia
Doenças Autoimunes/genética
Criança
Dermatologia
Anormalidades do Olho/terapia
Hipersensibilidade Alimentar/imunologia
Hemangioma/terapia
Seres Humanos
Síndromes Neurocutâneas/terapia
Pediatria
Fator de Transcrição STAT3/genética
Dermatopatias/diagnóstico
Dermatopatias/etiologia
Dermatopatias/terapia
Fenômenos Fisiológicos da Pele
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (STAT3 Transcription Factor); 0 (STAT3 protein, human)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


  4 / 13644 MEDLINE  
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[PMID]:29364614
[Au] Autor:Shumakova AA; Shipelin VA; Trushina EN; Mustaphina OK; Gmoshinsky IV; Khanferyan RA; Khotimchenko SA; Tutelyan VA
[Ti] Título:[Toxicological assessment of nanostructured silica. IV. Immunological and allergological indices in animals sensitized with food allergen and final discussioin].
[So] Source:Vopr Pitan;84(5):102-11, 2015.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:This paper is the final in a series of publications on the assessment of subacute oral toxicity of nanostructured silica (SiO2). Preparation studied was a commercial nanopowder of SiO2, obtained by hydrolysis of tetrachlorosilane in the gaseous phase with the size of primary nanoparticles (NPs) of 5­30 nm. The experiment was conducted in 95 male Wistar rats weighing 150­180 g, divided into 6 groups numbering 25 (group 1), 26 (group 2), 11 (groups 3­6) of animals. The aqueous dispersion of SiO2 after sonication was administered to animals of groups 2, 4 and 6 for 28 days by intragastric gavage at a dose of 100 mg/kg of body weight per day. Animals of groups 1, 3, and 5 were treated with deionized water. On the 1st, 3d, 5th and 21st day of experiment the rats of groups 1, 2, 3 and 4 were sensitized intraperitoneally with hen's egg ovalbumin (OVA) adsorbed to aluminum hydroxide. Intravenous administration of the challenge dose OVA to rats in groups 1 and 2 was carried out on the 29th day. In the same period animals of groups 3­6 were bled for analysis of cellular immunity. There were evaluated the severity of systemic anaphylaxis reaction, the level of specific IgG antibodies to OVA in sensitized animals, state of erythrocytes, platelets and leukocytes of peripheral blood using standard methods. Using flow cytometry there were measured contents of lymphocyte populations of B-lymphocytes (CD45RA+), total T-lymphocytes (CD3+), T-helper cells (CD4+), T-cytotoxic cells (CD8+), NKcells (CD161a+), phagocytic activity of polymorphonuclear leukocytes in respect of latex particles. Serum levels of TNFα and IL-10 cytokines were determined by ELISA. The result showed that NPs SiO2, at dose of 100 mg/kg body weight had no any marked effect on severity of active anaphylactic shock and level of specific antibodies. The changes in cellular immunity under the influence of nanomaterial had similar direction in sensitized and non-sensitized animals and were more pronounced in the latter. Based on the discussion of the results, together with data from previous publications it was concluded that oral maximum level without observable adverse effect (NOAEL) of nanostructured SiO2 is located below 100 mg/kg body weight.
[Mh] Termos MeSH primário: Anafilaxia/sangue
Hipersensibilidade Alimentar/sangue
Nanopartículas/efeitos adversos
Dióxido de Silício/efeitos adversos
[Mh] Termos MeSH secundário: Anafilaxia/patologia
Animais
Linfócitos B/metabolismo
Linfócitos B/patologia
Linfócitos T CD4-Positivos/metabolismo
Linfócitos T CD4-Positivos/patologia
Linfócitos T CD8-Positivos/metabolismo
Linfócitos T CD8-Positivos/patologia
Hipersensibilidade Alimentar/patologia
Imunoglobulina G/sangue
Interleucina-10/sangue
Masculino
Ratos
Ratos Wistar
Dióxido de Silício/farmacologia
Fator de Necrose Tumoral alfa/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G); 0 (Tumor Necrosis Factor-alpha); 130068-27-8 (Interleukin-10); 7631-86-9 (Silicon Dioxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE


  5 / 13644 MEDLINE  
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[PMID]:29234788
[Au] Autor:Abbasi J
[Ti] Título:Point-of-Use Food Allergen Detector on the Horizon.
[So] Source:JAMA;318(22):2173, 2017 Dec 12.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Alérgenos/análise
Técnicas de Química Analítica/instrumentação
Hipersensibilidade Alimentar
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:NEWS
[Nm] Nome de substância:
0 (Allergens)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.18651


  6 / 13644 MEDLINE  
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[PMID]:28456621
[Au] Autor:Johansson EK; Bergström A; Kull I; Lind T; Söderhäll C; van Hage M; Wickman M; Ballardini N; Wahlgren CF
[Ad] Endereço:Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Dermatological and Venereal Clinic, Södersjukhuset, Stockholm, Sweden. Electronic address: emma.k.johansson@sll.se.
[Ti] Título:IgE sensitization in relation to preschool eczema and filaggrin mutation.
[So] Source:J Allergy Clin Immunol;140(6):1572-1579.e5, 2017 Dec.
[Is] ISSN:1097-6825
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Eczema (atopic dermatitis) is associated with an increased risk of having IgE antibodies. IgE sensitization can occur through an impaired skin barrier. Filaggrin gene (FLG) mutation is associated with eczema and possibly also with IgE sensitization. OBJECTIVE: We sought to explore the longitudinal relation between preschool eczema (PSE), FLG mutation, or both and IgE sensitization in childhood. METHODS: A total of 3201 children from the BAMSE (Children Allergy Milieu Stockholm Epidemiology) birth cohort recruited from the general population were included. Regular parental questionnaires identified children with eczema. Blood samples were collected at 4, 8, and 16 years of age for analysis of specific IgE. FLG mutation analysis was performed on 1890 of the children. RESULTS: PSE was associated with IgE sensitization to both food allergens and aeroallergens up to age 16 years (overall adjusted odds ratio, 2.30; 95% CI, 2.00-2.66). This association was even stronger among children with persistent PSE. FLG mutation was associated with IgE sensitization to peanut at age 4 years (adjusted odds ratio, 1.88; 95% CI, 1.03-3.44) but not to other allergens up to age 16 years. FLG mutation and PSE were not effect modifiers for the association between IgE sensitization and PSE or FLG mutation, respectively. Sensitized children with PSE were characterized by means of polysensitization, but no other specific IgE sensitization patterns were found. CONCLUSIONS: PSE is associated with IgE sensitization to both food allergens and aeroallergens up to 16 years of age. FLG mutation is associated with IgE sensitization to peanut but not to other allergens. Sensitized children with preceding PSE are more often polysensitized.
[Mh] Termos MeSH primário: Eczema/imunologia
Hipersensibilidade Alimentar/imunologia
Proteínas de Filamentos Intermediários/genética
Mutação/genética
Pele/imunologia
[Mh] Termos MeSH secundário: Adolescente
Alérgenos/imunologia
Arachis/imunologia
Criança
Pré-Escolar
Estudos de Coortes
Análise Mutacional de DNA
Eczema/epidemiologia
Eczema/genética
Feminino
Hipersensibilidade Alimentar/epidemiologia
Hipersensibilidade Alimentar/genética
Estudos de Associação Genética
Genótipo
Seres Humanos
Imunização
Imunoglobulina E/metabolismo
Masculino
Pele/patologia
Suécia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Intermediate Filament Proteins); 0 (filaggrin); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


  7 / 13644 MEDLINE  
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[PMID]:29245212
[Au] Autor:Kang Y; Park SY; Noh S; Kim J; Seo B; Kwon OY; Kwon HS; Cho YS; Moon HB; Kim TB
[Ad] Endereço:aDepartment of Internal MedicinebDepartment of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
[Ti] Título:Case report: A first case of flaxseed-induced anaphylaxis in Korea.
[So] Source:Medicine (Baltimore);96(49):e8220, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Anaphylaxis is a serious, generalized allergic reaction typically triggered by drugs, food, and bee venom, which can be life-threatening. Seeds are one of the major food allergens and can cause anaphylaxis as well as systemic hypersensitivity reactions. Flaxseed has been widely used crop for numerous purposes, such as in alternative medicine and as a dietary supplement, hypersensitivity to it has rarely been reported. PATIENT CONCERNS: A 42-year-old female presenting with facial edema, dyspnea and urticaria after ingested half teaspoon of flaxseed flour 30 minutes previously. DIAGNOSES: A skin prick test for heated flaxseed flour extract showed negative responses, but intradermal test showed positivity which suggested an Immunoglobulin E-mediated reaction. INTERVENTIONS: The patient was instructed to avoid future ingestion of flaxseed. OUTCOMES: The patient had no recurrence of symptoms at 1-year follow-up. LESSONS: This is the first case of flaxseed-induced anaphylaxis in Korea, confirmed by an intradermal skin test.
[Mh] Termos MeSH primário: Anafilaxia/etiologia
Linho/efeitos adversos
Hipersensibilidade Alimentar/etiologia
Sementes/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
República da Coreia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008220


  8 / 13644 MEDLINE  
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[PMID]:29176842
[Au] Autor:Elbert NJ; Kiefte-de Jong JC; Voortman T; Nijsten TEC; de Jong NW; Jaddoe VWV; de Jongste JC; Gerth van Wijk R; Duijts L; Pasmans SGMA
[Ad] Endereço:The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
[Ti] Título:Allergenic food introduction and risk of childhood atopic diseases.
[So] Source:PLoS One;12(11):e0187999, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The role of timing and diversity of allergenic food introduction in the development of childhood allergic sensitization and atopic diseases is controversial. OBJECTIVE: To examine whether timing and diversity of allergenic food introduction are associated with allergic sensitization, allergy and eczema in children until age 10 years. MATERIALS AND METHODS: This study among 5,202 children was performed in a population-based prospective cohort. Timing (age ≤6 months vs. >6 months) and diversity (0, 1, 2 and ≥3 foods) of allergenic food (cow's milk, hen's egg, peanut, tree nuts, soy and gluten) introduction were assessed by questionnaires at ages 6 and 12 months. At age 10 years, inhalant and food allergic sensitization were measured by skin prick tests, and physician-diagnosed inhalant and food allergy by questionnaire. Data on parental-reported physician-diagnosed eczema were obtained from birth until age 10 years. RESULTS: Children introduced to gluten at age ≤6 months had a decreased risk of eczema (aOR (95% CI): 0.84 (0.72, 0.99)), compared with children introduced to gluten at age >6 months. However, timing of allergenic food introduction was not associated with allergic sensitization or physician-diagnosed allergy. Children introduced to ≥3 allergenic foods at age ≤6 months had a decreased risk of physician-diagnosed inhalant allergy (0.64 (0.42, 0.98)), compared with children not introduced to any allergenic food at age ≤6 months. However, diversity of allergenic food introduction was not associated with allergic sensitization, physician-diagnosed food allergy or eczema. CONCLUSION: Neither timing nor diversity of allergenic food introduction was consistently associated with childhood allergic sensitization, allergy or eczema.
[Mh] Termos MeSH primário: Eczema/etiologia
Hipersensibilidade Alimentar/complicações
[Mh] Termos MeSH secundário: Adulto
Criança
Feminino
Hipersensibilidade Alimentar/imunologia
Seres Humanos
Masculino
Fatores de Risco
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0187999


  9 / 13644 MEDLINE  
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[PMID]:29215217
[Au] Autor:Horowitz RS
[Ad] Endereço:Post Road Health Consultants, Niantic, CT horowitzrs@gmail.com
[Ti] Título:Food Allergy.
[So] Source:N Engl J Med;377(23):2294, 2017 12 07.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Hipersensibilidade Alimentar
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171214
[Lr] Data última revisão:
171214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMc1713844


  10 / 13644 MEDLINE  
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[PMID]:29211665
[Au] Autor:Jones SM; Burks AW
[Ad] Endereço:University of Arkansas for Medical Sciences, Little Rock, AR
[Ti] Título:Food Allergy.
[So] Source:N Engl J Med;377(23):2294-2295, 2017 12 07.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Hipersensibilidade Alimentar
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171214
[Lr] Data última revisão:
171214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMc1713844



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