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  1 / 546 MEDLINE  
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[PMID]:28731415
[Au] Autor:García Rodríguez R; Méndez Díaz Y; Moreno Lozano L; Extremera Ortega A; Gómez Torrijos E
[Ad] Endereço:Hospital General Universitario de Ciudad Real, Ciudad Real, Spain.
[Ti] Título:Eosinophilic Esophagitis After Egg Oral Immunotherapy in an Adult With Egg-Allergy and Egg-Bird Syndrome.
[So] Source:J Investig Allergol Clin Immunol;27(4):266-267, 2017.
[Is] ISSN:1018-9068
[Cp] País de publicação:Spain
[La] Idioma:eng
[Mh] Termos MeSH primário: Alérgenos/efeitos adversos
Galinhas
Dessensibilização Imunológica/efeitos adversos
Hipersensibilidade a Ovo/terapia
Esofagite Eosinofílica/etiologia
Óvulo
[Mh] Termos MeSH secundário: Administração Oral
Animais
Dietoterapia
Esofagite Eosinofílica/terapia
Feminino
Seres Humanos
Meia-Idade
Inibidores da Bomba de Prótons/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Proton Pump Inhibitors)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE
[do] DOI:10.18176/jiaci.0163


  2 / 546 MEDLINE  
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[PMID]:28731411
[Au] Autor:Martorell A; Alonso E; Echeverría L; Escudero C; García-Rodríguez R; Blasco C; Bone J; Borja-Segade J; Bracamonte T; Claver A; Corzo JL; De la Hoz B; Del Olmo R; Dominguez O; Fuentes-Aparicio V; Guallar I; Larramona H; Martín-Muñoz F; Matheu V; Michavila A; Ojeda I; Ojeda P; Piquer M; Poza P; Reche M; Rodríguez Del Río P; Rodríguez M; Ruano F; Sánchez-García S; Terrados S; Valdesoiro L; Vazquez-Ortiz M; Expert panel selected from members of the Spanish Society of Pediatric Allergology, Asthma and Clinical Immunology (SEICAP) and the Spanish Society of Allergology and Clinical Immunology (SEAIC)
[Ad] Endereço:Department of Allergology, University General Hospital, Valencia, Valencia, Spain.
[Ti] Título:Oral Immunotherapy for Food Allergy: A Spanish Guideline. Immunotherapy Egg and Milk Spanish Guide (ITEMS Guide). Part I: Cow Milk and Egg Oral Immunotherapy: Introduction, Methodology, Rationale, Current State, Indications, Contraindications, and Oral Immunotherapy Build-up Phase.
[So] Source:J Investig Allergol Clin Immunol;27(4):225-237, 2017.
[Is] ISSN:1018-9068
[Cp] País de publicação:Spain
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVE: Cow milk and egg are the most frequent causes of food allergy in the first years of life. Oral immunotherapy (OIT) has been investigated as an alternative to avoidance diets. No clinical practice guidelines on the management of OIT with milk and egg are currently available. Objectives: To develop clinical guidelines for OIT based on available scientific evidence and the opinions of experts. METHODS: A review was made of studies published between 1984 and June 2016, doctoral theses published in Spain, summaries of communications at scientific meetings (SEAIC, SEICAP, EAACI, and AAAAI), and the consensus of opinion established by a group of experts from the scientific societies SEICAP and SEAIC. RESULTS: Recommendations were established regarding the indications, requirements and practical aspects of the different phases of OIT, as well as special protocols for patients at high risk of adverse reactions. CONCLUSIONS: Clinical practice guidelines based on the consensus reached between Spanish experts are presented for the management of OIT with milk and egg.
[Mh] Termos MeSH primário: Alérgenos/uso terapêutico
Dessensibilização Imunológica/métodos
Hipersensibilidade a Ovo/terapia
Hipersensibilidade a Leite/terapia
[Mh] Termos MeSH secundário: Administração Oral
Seres Humanos
Guias de Prática Clínica como Assunto
Espanha
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Allergens)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE
[do] DOI:10.18176/jiaci.0177


  3 / 546 MEDLINE  
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[PMID]:28434227
[Au] Autor:Claude M; Bouchaud G; Lupi R; Castan L; Tranquet O; Denery-Papini S; Bodinier M; Brossard C
[Ad] Endereço:UR 1268 Biopolymers Interactions Assemblies, INRA , Nantes, France.
[Ti] Título:How Proteins Aggregate Can Reduce Allergenicity: Comparison of Ovalbumins Heated under Opposite Electrostatic Conditions.
[So] Source:J Agric Food Chem;65(18):3693-3701, 2017 May 10.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Heated foods are recommended for avoiding sensitization to food proteins, but depending on the physicochemical conditions during heating, more or less unfolded proteins aggregate differently. Whether the aggregation process could modulate allergenicity was investigated. Heating ovalbumin in opposite electrostatic conditions led to small (A-s, about 50 nm) and large (A-L, about 65 µm) aggregates that were used to sensitize mice. The symptoms upon oral challenge and rat basophil leukemia degranulation with native ovalbumin differed on the basis of which aggregates were used during the sensitization. Immunoglobulin-E (IgE) production was significantly lower with A-s than with A-L. Although two common linear IgE-epitopes were found, the aggregates bound and cross-linked IgE similarly or differently, depending on the sensitizing aggregate. The ovalbumin aggregates thus displayed a lower allergenic potential when formed under repulsive rather than nonrepulsive electrostatic conditions. This further demonstrates that food structure modulates the immune response during the sensitization phase with some effects on the elicitation phase of an allergic reaction and argues for the need to characterize the aggregation state of allergens.
[Mh] Termos MeSH primário: Alérgenos/química
Alérgenos/imunologia
Hipersensibilidade a Ovo/imunologia
Ovalbumina/química
Ovalbumina/imunologia
[Mh] Termos MeSH secundário: Animais
Basófilos/imunologia
Feminino
Temperatura Alta
Seres Humanos
Imunoglobulina G/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Agregados Proteicos
Ratos
Eletricidade Estática
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Immunoglobulin G); 0 (Protein Aggregates); 9006-59-1 (Ovalbumin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170608
[Lr] Data última revisão:
170608
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b00676


  4 / 546 MEDLINE  
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[PMID]:28283159
[Au] Autor:Chan JC; Peters RL; Koplin JJ; Dharmage SC; Gurrin LC; Wake M; Tang ML; Prescott S; Allen KJ; HealthNuts Study
[Ad] Endereço:Murdoch Childrens Research Institute, Parkville, Victoria, Australia; Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
[Ti] Título:Food Challenge and Community-Reported Reaction Profiles in Food-Allergic Children Aged 1 and 4 Years: A Population-Based Study.
[So] Source:J Allergy Clin Immunol Pract;5(2):398-409.e3, 2017 Mar - Apr.
[Is] ISSN:2213-2201
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Oral food challenge is the main tool for diagnosing food allergy, but there is little data on the reaction profiles of young children undergoing challenges, nor how these reactions compare to reactions on accidental ingestion in the community. OBJECTIVES: To compare reaction profiles from food challenges and parent-reported reactions on accidental ingestion, and assess predictors of severe reactions. METHODS: HealthNuts is a longitudinal population-based cohort study of 5276 1-year-old infants. Infants underwent skin prick tests and those with identifiable wheals were offered food challenges. Food challenges were repeated at age 4 years in those with previous food allergy or reporting new food allergies. Community-reported reactions were ascertained from parent questionnaires. RESULTS: Food challenges were undertaken in 916 children at age 1 year and 357 children at age 4 years (a total of 2047 peanut, egg, or sesame challenges). Urticaria was the most common sign in positive challenges at both ages (age 1 year, 88.7%, and age 4 years, 71.2%) although angioedema was significantly more common at age 4 years (40.1%) than at age 1 year (12.9%). Anaphylaxis was equally uncommon at both ages (2.1% and 2.8% of positive challenges at ages 1 and 4 years, respectively) but more common for peanut than for egg (4.5% and 1.2% of positive challenges at ages 1 and 4 years, respectively). The patterns of presenting signs reported during community reactions were similar to those observed in formal food challenges. Serum food-specific IgE levels of 15 kU/L or more were associated with moderate to severe reactions but skin prick test was not. CONCLUSIONS: There was a shift from the most common presenting reaction of urticaria during food challenges toward more angioedema in older children. Serum food-specific IgE levels were associated with reaction severity.
[Mh] Termos MeSH primário: Anafilaxia/prevenção & controle
Hipersensibilidade a Ovo/diagnóstico
Hipersensibilidade a Amendoim/diagnóstico
Sesamum/imunologia
[Mh] Termos MeSH secundário: Administração Oral
Alérgenos/imunologia
Anafilaxia/etiologia
Arachis/imunologia
Pré-Escolar
Estudos de Coortes
Hipersensibilidade a Ovo/complicações
Ovos/efeitos adversos
Feminino
Seres Humanos
Imunização/efeitos adversos
Imunização/métodos
Imunoglobulina E/sangue
Lactente
Masculino
Hipersensibilidade a Amendoim/complicações
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE


  5 / 546 MEDLINE  
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[PMID]:28276109
[Au] Autor:Fleischer DM
[Ad] Endereço:Department of Pediatrics, Section of Allergy and Immunology, University of Colorado Denver School of Medicine, Children's Hospital Colorado, Aurora, Colorado, United States.
[Ti] Título:Life after LEAP: How to implement advice on introducing peanuts in early infancy.
[So] Source:J Paediatr Child Health;53(S1):3-9, 2017 Mar.
[Is] ISSN:1440-1754
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:The increase in food allergies worldwide has led to mounting concern among healthcare providers, families, schools, and the food industry. Of particular interest is the growing prevalence of peanut allergy. The Learning Early About Peanut Allergy (LEAP) study confirms that the early introduction of peanut significantly decreases the risk of developing peanut allergy among high-risk children. However, a number of issues, such as a unified definition of high risk and whether or not to screen patients before peanut introduction, remain. This article will review the LEAP findings and the new peanut allergy prevention guidelines, and then briefly discuss recommendations on the introduction of other allergenic foods based on results from other food allergy prevention randomised controlled trials.
[Mh] Termos MeSH primário: Arachis
Dieta
Hipersensibilidade a Amendoim/prevenção & controle
[Mh] Termos MeSH secundário: Fatores Etários
Eczema/imunologia
Hipersensibilidade a Ovo
Hipersensibilidade Alimentar/epidemiologia
Hipersensibilidade Alimentar/prevenção & controle
Seres Humanos
Lactente
Hipersensibilidade a Amendoim/epidemiologia
Prevalência
Risco
Testes Cutâneos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1111/jpc.13491


  6 / 546 MEDLINE  
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[PMID]:28231415
[Au] Autor:Pang L; Macauley MS; Arlian BM; Nycholat CM; Paulson JC
[Ad] Endereço:Department of Molecular Medicine, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA, 92037, USA.
[Ti] Título:Encapsulating an Immunosuppressant Enhances Tolerance Induction by Siglec-Engaging Tolerogenic Liposomes.
[So] Source:Chembiochem;18(13):1226-1233, 2017 Jul 04.
[Is] ISSN:1439-7633
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Unwanted antibody responses significantly impact human health, and current options for treating deleterious antibody responses largely rely on broad immunosuppressants that can compromise overall immunity. A desirable alternative is to induce antigen-specific immune tolerance. We have shown that co-presentation of antigen and ligands of B cell sialic acid-binding immunoglobulin-like lectins (Siglecs) on a liposomal nanoparticle induces antigen-specific tolerance. Although Siglec-engaging tolerance-inducing antigenic liposomes (STALs) induce robust B cell tolerance in naïve mice, the full potential of STALs requires long-term tolerance induction and suppression of an ongoing immune response. We hypothesized that STALs encapsulated with rapamycin (RAPA), an immunomodulator, could improve the efficacy of STALs and potentially enable their use in the context of immunological memory. Here, we showed that formulation of STALs with RAPA produced enhanced tolerance induction in naïve mice compared to STALs without RAPA but had minimal impact on inducing tolerance in previously sensitized mice. These findings indicate that the addition of immunomodulators to STALs could be beneficial in tolerance induction and support future development of STALs for the treatment of allergy and autoimmune diseases.
[Mh] Termos MeSH primário: Antialérgicos/farmacologia
Hipersensibilidade a Ovo/terapia
Tolerância Imunológica/efeitos dos fármacos
Imunossupressores/farmacologia
Lipossomos/farmacologia
Lectinas Semelhantes a Imunoglobulina de Ligação ao Ácido Siálico/imunologia
Sirolimo/farmacologia
[Mh] Termos MeSH secundário: Animais
Antialérgicos/imunologia
Anticorpos/sangue
Anticorpos/efeitos dos fármacos
Antígenos/imunologia
Antígenos/farmacologia
Linfócitos B/efeitos dos fármacos
Linfócitos B/imunologia
Linfócitos B/patologia
Composição de Medicamentos
Hipersensibilidade a Ovo/genética
Hipersensibilidade a Ovo/imunologia
Expressão Gênica
Seres Humanos
Imunossupressores/química
Ligantes
Lipossomos/imunologia
Ativação Linfocitária/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos C57BL
Ovalbumina
Lectinas Semelhantes a Imunoglobulina de Ligação ao Ácido Siálico/genética
Sirolimo/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Allergic Agents); 0 (Antibodies); 0 (Antigens); 0 (Immunosuppressive Agents); 0 (Ligands); 0 (Liposomes); 0 (Sialic Acid Binding Immunoglobulin-like Lectins); 9006-59-1 (Ovalbumin); W36ZG6FT64 (Sirolimus)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE
[do] DOI:10.1002/cbic.201600702


  7 / 546 MEDLINE  
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[PMID]:28230769
[Au] Autor:Dhanapala P; Withanage-Dona D; Tang ML; Doran T; Suphioglu C
[Ad] Endereço:Neuro Allergy Research Laboratory (NARL), School of Life and Environmental Sciences, Faculty of Science, Engineering and Built Environment, Deakin University, 75 Pigdons Road, Geelong 3216 VIC, Australia. dpathum@deakin.edu.au.
[Ti] Título:Hypoallergenic Variant of the Major Egg White Allergen Gal d 1 Produced by Disruption of Cysteine Bridges.
[So] Source:Nutrients;9(2), 2017 Feb 21.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Gal d 1 (ovomucoid) is the dominant allergen in the chicken egg white. Hypoallergenic variants of this allergen can be used in immunotherapy as an egg allergy treatment approach. We hypothesised that disruption of two of the nine cysteine-cysteine bridges by site-directed mutagenesis will allow the production of a hypoallergenic variant of the protein; Methods: Two cysteine residues at C192 and C210 in domain III of the protein were mutated to alanine using site-directed mutagenesis, to disrupt two separate cysteine-cysteine bridges. The mutated and non-mutated proteins were expressed in ( ) by induction with isopropyl ß-d-1-thiogalactopyranoside (IPTG). The expressed proteins were analysed using sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting to confirm expression. Immunoglobulin E (IgE) reactivity of the two proteins was analysed, by immunoblotting, against a pool of egg-allergic patients' sera. A pool of non-allergic patients' sera was also used in a separate blot as a negative control; Results: Mutant Gal d 1 showed diminished IgE reactivity in the immunoblot by showing lighter bands when compared to the non-mutated version, although there was more of the mutant protein immobilised on the membrane when compared to the wild-type protein. The non-allergic negative control showed no bands, indicating an absence of non-specific binding of secondary antibody to the proteins; Conclusion: Disruption of two cysteine bridges in domain III of Gal d 1 reduces IgE reactivity. Following downstream laboratory and clinical testing, this mutant protein can be used in immunotherapy to induce tolerance to Gal d 1 and in egg allergy diagnosis.
[Mh] Termos MeSH primário: Alérgenos/genética
Cisteína/metabolismo
Hipersensibilidade a Ovo
Clara de Ovo/química
Tolerância Imunológica
Mutação
Ovomucina/genética
[Mh] Termos MeSH secundário: Animais
Galinhas
Hipersensibilidade a Ovo/imunologia
Hipersensibilidade a Ovo/prevenção & controle
Escherichia coli
Feminino
Técnicas Genéticas
Seres Humanos
Imunoglobulina E/metabolismo
Imunoterapia
Mutagênese
Ovomucina/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 37281-36-0 (Ovomucin); 37341-29-0 (Immunoglobulin E); K848JZ4886 (Cysteine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170705
[Lr] Data última revisão:
170705
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE


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[PMID]:28211344
[Au] Autor:González-Mancebo E; Alonso Díaz de Durana MD; García Estringana Y; Meléndez Baltanás A; Rodriguez-Alvarez M; de la Hoz Caballer B; Del Prado N; Fernández-Rivas M
[Ad] Endereço:Allergy Department, Hospital Universitario de Fuenlabrada, Madrid, Spain.
[Ti] Título:Validation of Recipes for Double-Blind Placebo-Controlled Challenges With Milk, Egg White, and Hazelnut.
[So] Source:J Investig Allergol Clin Immunol;27(1):40-45, 2017.
[Is] ISSN:1018-9068
[Cp] País de publicação:Spain
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The double-blind, placebo-controlled food challenge (DBPCFC) is considered the definitive diagnostic test for food allergy. Nevertheless, validated recipes for masking the foods are scarce, have not been standardized, and differ between centers. Sensory evaluation techniques such as the triangle test are necessary to validate the recipes used for DBPCFC. METHODS: We developed 3 recipes for use in DBPCFC with milk, egg white, and hazelnut and used the triangle test to validate them in a 2-phase study in which 197 volunteers participated. In each phase, participants tried 3 samples (2 active-1 placebo or 2 placebo-1 active) and had to identify the odd one. In phase 1, the 3 samples were given simultaneously, whereas in phase 2, the 3 samples of foods that failed validation in phase 1 were given sequentially. A visual analog scale (VAS) ranging from 1 to 10 was used to evaluate how much participants liked the recipes. RESULTS: In phase 1, the egg white recipe was validated (n=89 volunteers, 38.9% found the odd sample, P=.16). Milk and hazelnut recipes were validated in phase 2 (for both foods, n=30 participants, 36.7% found the odd sample, P=.36). Median VAS scores for the 3 recipes ranged from 6.6 to 9.7. CONCLUSIONS: We used sensory testing to validate milk, egg white, and hazelnut recipes for use in DBPCFC. The validated recipes are easy to prepare in a clinical setting, provide the equivalent of 1 serving dose, and were liked by most participants.
[Mh] Termos MeSH primário: Corylus
Hipersensibilidade a Ovo/diagnóstico
Proteínas do Ovo/administração & dosagem
Testes Imunológicos
Hipersensibilidade a Leite/diagnóstico
Proteínas do Leite/administração & dosagem
Hipersensibilidade a Noz/diagnóstico
Preparações de Plantas/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Culinária
Corylus/efeitos adversos
Corylus/imunologia
Método Duplo-Cego
Hipersensibilidade a Ovo/imunologia
Proteínas do Ovo/efeitos adversos
Proteínas do Ovo/imunologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Hipersensibilidade a Leite/imunologia
Proteínas do Leite/efeitos adversos
Proteínas do Leite/imunologia
Hipersensibilidade a Noz/imunologia
Satisfação do Paciente
Preparações de Plantas/efeitos adversos
Preparações de Plantas/imunologia
Valor Preditivo dos Testes
Reprodutibilidade dos Testes
Sensação
Espanha
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Egg Proteins); 0 (Milk Proteins); 0 (Plant Preparations)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE
[do] DOI:10.18176/jiaci.0084


  9 / 546 MEDLINE  
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[PMID]:28173607
[Au] Autor:Mermiri DT; Lappa T; Papadopoulou AL
[Ad] Endereço:Allergology and Pulmonology Unit, Penteli's Children Hospital, Athens, Greece.
[Ti] Título:Review suggests that the immunoregulatory and anti-inflammatory properties of allergenic foods can provoke oral tolerance if introduced early to infants' diets.
[So] Source:Acta Paediatr;106(5):721-726, 2017 May.
[Is] ISSN:1651-2227
[Cp] País de publicação:Norway
[La] Idioma:eng
[Ab] Resumo:For years, the advice was to postpone introducing allergenic foods, in order to prevent food allergies. However, food allergies have escalated rather than declined and our review of the latest epidemiological, immunological and nutritional research suggests that early weaning practices may be beneficial. The most allergenic foods, such as fish, eggs and peanuts, have proved to be inherently rich in tolerogenic substances that can play a significant role in preventing allergies. CONCLUSION: We found evidence that the immunoregulatory and anti-inflammatory properties of allergenic foods can provoke oral tolerance if introduced early to both low-risk and high-risk infants.
[Mh] Termos MeSH primário: Hipersensibilidade a Ovo/imunologia
Tolerância Imunológica
Hipersensibilidade a Amendoim/imunologia
Desmame
[Mh] Termos MeSH secundário: Hipersensibilidade a Ovo/prevenção & controle
Seres Humanos
Lactente
Hipersensibilidade a Amendoim/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170208
[St] Status:MEDLINE
[do] DOI:10.1111/apa.13778


  10 / 546 MEDLINE  
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[PMID]:28120742
[Au] Autor:Greenhawt M
[Ti] Título:The National Institutes of Allergy and Infectious Diseases sponsored guidelines on preventing peanut allergy: A new paradigm in food allergy prevention.
[So] Source:Allergy Asthma Proc;38(2):92-97, 2017 Mar 24.
[Is] ISSN:1539-6304
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Peanut allergy is a significant public health problem without proven treatment or cure at present. In 2000, the American Academy of Pediatrics recommended that solid-food introduction be delayed in infants at high risk, including peanut introduction, until age 3 years. In 2008, the American Academy of Pediatrics revised these recommendations based on limited evidence of benefit and, instead, recommended solid-food introduction not be delayed past 4-6 months of life. In 2015, the Learning Early About Peanut Allergy study showed that early peanut introduction (between 4 and 11 months of life) was associated with a significant absolute and relative risk reduction in the development of peanut allergy compared with delayed introduction. Based on these findings, the National Institutes of Allergy and Infectious Diseases sponsored an expert panel to create an addendum to the 2010 Food Allergy Guidelines that specifically focuses on peanut allergy prevention. The addendum recommends that children with severe eczema, egg allergy, or both have peanut introduced as early as 4-6 months of life, after assessment by a trained allergy specialist. For children with mild-to-moderate eczema, peanut can be introduced at ∼6 months, without the need for specialist evaluation. For children with no eczema, peanut can be introduced in accordance with family and cultural preferences, without the need for specialist evaluation. Adherence to these clinical practice recommendations can help potentially reduce the number of cases of peanut allergy per year. However, this can only be accomplished with the cooperation of parents and health care providers who adhere to these recommendations.
[Mh] Termos MeSH primário: Comportamento Alimentar
Hipersensibilidade a Amendoim/prevenção & controle
Guias de Prática Clínica como Assunto
Comportamento de Redução do Risco
[Mh] Termos MeSH secundário: Fatores Etários
Pré-Escolar
Comorbidade
Dermatite Atópica/epidemiologia
Hipersensibilidade a Ovo/epidemiologia
Seres Humanos
Lactente
National Institute of Allergy and Infectious Diseases (U.S.)
Hipersensibilidade a Amendoim/epidemiologia
Prevenção Primária
Medição de Risco
Prevenção Secundária
Índice de Gravidade de Doença
Estados Unidos
Desmame
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE
[do] DOI:10.2500/aap.2017.38.4037



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