Base de dados : MEDLINE
Pesquisa : C20.543.480.370.500 [Categoria DeCS]
Referências encontradas : 2092 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 210 ir para página                         

  1 / 2092 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29298008
[Au] Autor:Novik GA; Khaleva EG; Bychkova NV; Zdanova MV
[Ti] Título:Evaluation of Efficacy and Safety of Longterm Feeding with Amino Acid-Based Formula in Infants with Cow's Milk Protein Allergy: Results of the Open-Label Prospective Controlled Post-Registration Trial.
[So] Source:Vestn Ross Akad Med Nauk;71(6):446-57, 2016.
[Is] ISSN:0869-6047
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:Background: The cow's milk allergy (CMA) prevalence is 2−3% in children under one year. Approximately in 5% of cases transferring to extensively hydrolysed formula (eHF) doesn't lead to disappearance of CMA symptoms. Aims: Evaluation of efficacy and safety of amino-acid formula (AAF) longterm feeding in children under one year and development of predictors of successful transfer from AAF to eHF. Materials and Methods: In open-label prospective post-registration trial duration of 365 days were included 43 children aged from 3 to 12 months with CMA. CMA was based on Russian and international guidelines. When a patient was included in the trial, child received eHF for 4 weeks with the evaluation of the effect of elimination diet (ED): in case of absence of effect, for diagnostic purposes child feed with AAF for 2 weeks and upon receiving the effect, child continued to receive it for at least 6 months. Diet was considered effective if there were observed disappearance of clinical manifestations of CMA during of formula using. Results: Children fed with AAF gain weight and increased height statistically higher during the first 6 months, compared with children receiving eHF, but without subsequent difference in a year. After 4 weeks' of AAF feeding, there was a significant decrease in SCORAD index from 46.84 (SD 4.164) to 2.52 (SD 2.204) (p=0.005); disappearance of gastrointestinal manifestations of CMA from 3 to 14 day. After 4 weeks, the 100% normalization of previously elevated faecal calprotectin (p<0.05) was observed; and after 6months. ED, in 60% of children normalization of the index of activation of basophils with milk was observed. 38.7% of children were transferred to eHF in 6 months, 12.9% and 25.8% in 9 and 12 months respectively. Conclusions: Use of AAF for children with CMA is an effective and safe treatment without lengthening the period of elimination, which is necessary for the formation of tolerance to cow's milk protein and has a positive impact on weight and height. Normalization of specific activation of basophils with milk could be considered as a predictor of successful transfer from AAF to eHF in children with CMA.
[Mh] Termos MeSH primário: Aminoácidos/farmacologia
Fórmulas Infantis
Hipersensibilidade a Leite
Hidrolisados de Proteína/farmacologia
[Mh] Termos MeSH secundário: Antropometria/métodos
Desenvolvimento Infantil/fisiologia
Feminino
Seres Humanos
Imunoglobulina E/análise
Lactente
Fórmulas Infantis/análise
Fórmulas Infantis/química
Fórmulas Infantis/classificação
Masculino
Hipersensibilidade a Leite/diagnóstico
Hipersensibilidade a Leite/dietoterapia
Hipersensibilidade a Leite/etiologia
Hipersensibilidade a Leite/fisiopatologia
Monitorização Fisiológica/métodos
Vigilância de Produtos Comercializados/métodos
Estudos Prospectivos
Federação Russa
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Protein Hydrolysates); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.15690/vramn757


  2 / 2092 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29363931
[Au] Autor:Kharitonov VD; Agarkova EY; Kruchinin AG; Ryazantseva KA; Korolyeva OV; Fedorova TV; Zvereva EA; Tyazhelova TV; Maloshenok LG; Revyakina VA; Georgieva OV; Ponomareva NV; Melnikova EI; Laptev GY; Ilina LA
[Ti] Título:[Impact of new fermented dairy product with whey protein hydrolysate on tolerance and dynamics of atopic dermatitis manifestation in children suffering from cow's milk protein allergy].
[So] Source:Vopr Pitan;84(5):56-63, 2015.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Mh] Termos MeSH primário: Produtos Fermentados do Leite
Dermatite Atópica/dietoterapia
Hipersensibilidade a Leite/dietoterapia
Hidrolisados de Proteína/administração & dosagem
Proteínas do Soro do Leite/administração & dosagem
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Dermatite Atópica/sangue
Feminino
Seres Humanos
Imunoglobulina E/sangue
Imunoglobulina G/sangue
Masculino
Hipersensibilidade a Leite/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G); 0 (Protein Hydrolysates); 0 (Whey Proteins); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE


  3 / 2092 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:29199793
[Au] Autor:Piekkala A; Kaila M; Virtanen S; Luukkainen P
[Ti] Título:The effect of elimination diet on the growth of a child with milk allergy - a systematic review.
[So] Source:Duodecim;132(24):2335-41, 2016.
[Is] ISSN:0012-7183
[Cp] País de publicação:Finland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cow's milk is the most common food allergen in children under 3 years of age. Milk allergy is treated by eliminating milk from the diet. METHODS: The present study was conducted according to international guidelines for systematic reviews. RESULTS: In all three articles included in the current study, children with milk allergy were of lower weight than the controls. Furthermore, in one of the studies included, growth of the children with mild allergy was stunted. DISCUSSION: The current review shows that milk allergy is associated with stunted growth in childhood. The reasons for this growth retardation are unclear.
[Mh] Termos MeSH primário: Desenvolvimento Infantil
Transtornos do Crescimento/fisiopatologia
Hipersensibilidade a Leite/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Peso Corporal
Bovinos
Seres Humanos
Lactente
Recém-Nascido
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


  4 / 2092 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27771084
[Au] Autor:Fotschki J; Szyc AM; Laparra JM; Markiewicz LH; Wróblewska B
[Ad] Endereço:Department of Immunology and Food Microbiology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10, 10-748 Olsztyn, Poland.
[Ti] Título:Immune-modulating properties of horse milk administered to mice sensitized to cow milk.
[So] Source:J Dairy Sci;99(12):9395-9404, 2016 Dec.
[Is] ISSN:1525-3198
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to examine immune adaptive changes, the expression of innate biomarkers and variations in intestinal microbiota composition after horse-milk administration in BALB/c mice, which were sensitized intraperitoneally using cow ß-lactoglobulin and α-casein with aluminum adjuvant. We measured serum antibody IgE levels and the expression of MCP-1, IL-4, and TNF-α in duodenal samples. Changes in immune cell populations in peripheral blood were quantified using flow cytometry, and intestinal microbiota composition was assessed using real-time PCR. We found that horse-milk administration decreased serum IgE levels in sensitized mice. The groups that received horse milk showed an increased population of regulatory T cells (CD4 Foxp3 ). Horse-milk administration decreased the mRNA levels of IL-4 and resulted in higher transcripts of TLR-4 in all treatment groups; however, the levels of MCP-1, TNF-α, and TLR-2 were unaltered. After horse-milk treatment, we observed a positive effect, with increased numbers of intestinal Bifidobacterium spp. We observed immune-modulating properties of horse milk, but future studies should focus on testing horse-milk processing, such as fermentation and destroying most allergenic epitopes to continue research under clinical conditions.
[Mh] Termos MeSH primário: Lactoglobulinas/imunologia
Leite
[Mh] Termos MeSH secundário: Animais
Caseínas/genética
Bovinos
Feminino
Imunoglobulina E/sangue
Camundongos
Hipersensibilidade a Leite/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caseins); 0 (Lactoglobulins); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171204
[Lr] Data última revisão:
171204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  5 / 2092 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28787733
[Au] Autor:Gil F; Amezqueta A; Martinez D; Aznal E; Etayo V; Durá T; Sánchez-Valverde F
[Ad] Endereço:Department of Pediatrics, Estella Hospital, Estella, Spain.
[Ti] Título:Association between Caesarean Delivery and Isolated Doses of Formula Feeding in Cow Milk Allergy.
[So] Source:Int Arch Allergy Immunol;173(3):147-152, 2017.
[Is] ISSN:1423-0097
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cow milk allergy (CMA) is the most common food allergy in breastfed infants. The aim of this study is to verify whether certain perinatal factors may influence the development of CMA immunoglobulin E (IgE)+. METHODS: A retrospective, observational study of case and control groups was carried out. Information was collected of patients with CMA IgE+ from our department during the years 1990-2013. Patients of the same age and sex were recruited for the control group. Information on the following variables was collected: sex, age, pregnancy tolerance, duration of pregnancy, type of delivery, isolated doses of formula feeding in hospital (FFH), duration of breastfeeding, and family history of allergy (defined as ≥1 first-degree family member with allergic disease). Statistical analysis was performed using multivariate logistic regression techniques. RESULTS: A total of 211 cases were included in this study. Multivariate analysis showed an influence of duration of breastfeeding, FFH to be a risk factor (OR 4.94; 95% CI 2.68-9.08), especially in caesarean delivery (OR 11.82; 95% CI 2.64-47.50), and prematurity (OR 0.29; 95% CI 0.09-0.92) to be a protective factor. CONCLUSIONS: Perinatal factors play a key role in the development of CMA IgE+, with an influence of breastfeeding duration, FFH and caesarean delivery as risk factors and prematurity as a protective factor. While family history had no important role, environmental factors were more decisive.
[Mh] Termos MeSH primário: Fórmulas Infantis/utilização
Hipersensibilidade a Leite/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Aleitamento Materno
Cesárea
Criança
Feminino
Seres Humanos
Imunoglobulina E/imunologia
Lactente
Masculino
Hipersensibilidade a Leite/imunologia
Gravidez
Estudos Retrospectivos
Fatores de Risco
Espanha
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE
[do] DOI:10.1159/000477725


  6 / 2092 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28731417
[Au] Autor:Mori F; Sarti L; Barni S; Pucci N; Belli F; Stagi S; Novembre E
[Ad] Endereço:Allergy Unit, Department of Pediatrics, Anna Meyer Children's University Hospital, Florence, Italy.
[Ti] Título:Donkey´s Milk Is Well Accepted and Tolerated by Infants With Cow´s Milk Food Protein-Induced Enterocolitis Syndrome: A Preliminary Study.
[So] Source:J Investig Allergol Clin Immunol;27(4):269-271, 2017.
[Is] ISSN:1018-9068
[Cp] País de publicação:Spain
[La] Idioma:eng
[Mh] Termos MeSH primário: Alérgenos/imunologia
Enterocolite/imunologia
Hipersensibilidade a Leite/imunologia
Leite/imunologia
[Mh] Termos MeSH secundário: Animais
Bovinos
Enterocolite/etiologia
Equidae
Feminino
Cabras
Seres Humanos
Lactente
Masculino
Hipersensibilidade a Leite/complicações
Testes Cutâneos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE
[do] DOI:10.18176/jiaci.0167


  7 / 2092 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28731411
[Au] Autor:Martorell A; Alonso E; Echeverría L; Escudero C; García-Rodríguez R; Blasco C; Bone J; Borja-Segade J; Bracamonte T; Claver A; Corzo JL; De la Hoz B; Del Olmo R; Dominguez O; Fuentes-Aparicio V; Guallar I; Larramona H; Martín-Muñoz F; Matheu V; Michavila A; Ojeda I; Ojeda P; Piquer M; Poza P; Reche M; Rodríguez Del Río P; Rodríguez M; Ruano F; Sánchez-García S; Terrados S; Valdesoiro L; Vazquez-Ortiz M; Expert panel selected from members of the Spanish Society of Pediatric Allergology, Asthma and Clinical Immunology (SEICAP) and the Spanish Society of Allergology and Clinical Immunology (SEAIC)
[Ad] Endereço:Department of Allergology, University General Hospital, Valencia, Valencia, Spain.
[Ti] Título:Oral Immunotherapy for Food Allergy: A Spanish Guideline. Immunotherapy Egg and Milk Spanish Guide (ITEMS Guide). Part I: Cow Milk and Egg Oral Immunotherapy: Introduction, Methodology, Rationale, Current State, Indications, Contraindications, and Oral Immunotherapy Build-up Phase.
[So] Source:J Investig Allergol Clin Immunol;27(4):225-237, 2017.
[Is] ISSN:1018-9068
[Cp] País de publicação:Spain
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVE: Cow milk and egg are the most frequent causes of food allergy in the first years of life. Oral immunotherapy (OIT) has been investigated as an alternative to avoidance diets. No clinical practice guidelines on the management of OIT with milk and egg are currently available. Objectives: To develop clinical guidelines for OIT based on available scientific evidence and the opinions of experts. METHODS: A review was made of studies published between 1984 and June 2016, doctoral theses published in Spain, summaries of communications at scientific meetings (SEAIC, SEICAP, EAACI, and AAAAI), and the consensus of opinion established by a group of experts from the scientific societies SEICAP and SEAIC. RESULTS: Recommendations were established regarding the indications, requirements and practical aspects of the different phases of OIT, as well as special protocols for patients at high risk of adverse reactions. CONCLUSIONS: Clinical practice guidelines based on the consensus reached between Spanish experts are presented for the management of OIT with milk and egg.
[Mh] Termos MeSH primário: Alérgenos/uso terapêutico
Dessensibilização Imunológica/métodos
Hipersensibilidade a Ovo/terapia
Hipersensibilidade a Leite/terapia
[Mh] Termos MeSH secundário: Administração Oral
Seres Humanos
Guias de Prática Clínica como Assunto
Espanha
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Allergens)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE
[do] DOI:10.18176/jiaci.0177


  8 / 2092 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28687275
[Au] Autor:Hyytinen M; Savilahti E; Virtanen SM; Härkönen T; Ilonen J; Luopajärvi K; Uibo R; Vaarala O; Åkerblom HK; Knip M; Finnish TRIGR Pilot Study Group
[Ad] Endereço:Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.
[Ti] Título:Avoidance of Cow's Milk-Based Formula for At-Risk Infants Does Not Reduce Development of Celiac Disease: A Randomized Controlled Trial.
[So] Source:Gastroenterology;153(4):961-970.e3, 2017 Oct.
[Is] ISSN:1528-0012
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND & AIMS: Feeding during the first months of life might affect risk for celiac disease. Individuals with celiac disease or type 1 diabetes have been reported to have high titers of antibodies against cow's milk proteins. Avoidance of cow's milk-based formula for infants with genetic susceptibility for type 1 diabetes reduced the cumulative incidence of diabetes-associated autoantibodies. We performed a randomized controlled trial in the same population to study whether weaning to an extensively hydrolyzed formula reduced the risk of celiac disease autoimmunity or celiac disease. METHODS: We performed a double-blind controlled trial of 230 infants with HLA-defined predisposition to type 1 diabetes and at least 1 family member with type 1 diabetes. The infants were randomly assigned to groups fed a casein hydrolysate formula (n = 113) or a conventional formula (control, n = 117) whenever breast milk was not available during the first 6-8 months of life. Serum samples were collected over a median time period of 10 years and analyzed for antibodies to tissue transglutaminase (anti-TG2A) using a radiobinding assay, to endomysium using an immunofluorescence assay, and antibodies to a deamidated gliadine peptide using an immunofluorometry assay. Duodenal biopsies were collected if levels of anti-TG2A exceeded 20 relative units. Cow's milk antibodies were measured during the first 2 years of life. RESULTS: Of the 189 participants analyzed for anti-TG2A, 25 (13.2%) tested positive. Of the 230 study participants observed, 10 (4.3%) were diagnosed with celiac disease. We did not find any significant differences at the cumulative incidence of anti-TG2A positivity (hazard ratio, 1.14; 95% confidence interval, 0.51-2.54) or celiac disease (hazard ratio, 4.13; 95% confidence interval, 0.81-21.02) between the casein hydrolysate and cow's milk groups. Children who developed celiac disease had increased titers of cow's milk antibodies before the appearance of anti-TG2A or celiac disease. CONCLUSIONS: In a randomized controlled trial of 230 infants with genetic risk factors for celiac disease, we did not find evidence that weaning to a diet of extensively hydrolyzed formula compared with cow's milk-based formula would decrease the risk for celiac disease later in life. Increased titers of cow's milk antibody before anti-TG2A and celiac disease indicates that subjects with celiac disease might have increased intestinal permeability in early life. ClinicalTrials.gov Number: NCT00570102.
[Mh] Termos MeSH primário: Autoanticorpos/sangue
Autoimunidade
Caseínas/uso terapêutico
Doença Celíaca/prevenção & controle
Diabetes Mellitus Tipo 1/imunologia
Proteínas de Ligação ao GTP/imunologia
Fórmulas Infantis/efeitos adversos
Hipersensibilidade a Leite/prevenção & controle
Proteínas do Leite/efeitos adversos
Transglutaminases/imunologia
[Mh] Termos MeSH secundário: Biópsia
Caseínas/efeitos adversos
Caseínas/imunologia
Doença Celíaca/diagnóstico
Doença Celíaca/imunologia
Criança
Pré-Escolar
Diabetes Mellitus Tipo 1/sangue
Diabetes Mellitus Tipo 1/diagnóstico
Diabetes Mellitus Tipo 1/genética
Método Duplo-Cego
Duodeno/imunologia
Duodeno/patologia
Finlândia
Gliadina/imunologia
Seres Humanos
Lactente
Hipersensibilidade a Leite/diagnóstico
Hipersensibilidade a Leite/imunologia
Proteínas do Leite/imunologia
Medição de Risco
Fatores de Risco
Testes Sorológicos
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Autoantibodies); 0 (Caseins); 0 (Milk Proteins); 65072-00-6 (casein hydrolysate); 9007-90-3 (Gliadin); EC 2.3.2.- (transglutaminase 2); EC 2.3.2.13 (Transglutaminases); EC 3.6.1.- (GTP-Binding Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170709
[St] Status:MEDLINE


  9 / 2092 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28597347
[Au] Autor:Bartuzi Z; Cocco RR; Muraro A; Nowak-Wegrzyn A
[Ad] Endereço:Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Torun, Poland.
[Ti] Título:Contribution of Molecular Allergen Analysis in Diagnosis of Milk Allergy.
[So] Source:Curr Allergy Asthma Rep;17(7):46, 2017 Jul.
[Is] ISSN:1534-6315
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: We sought to describe the available evidence supporting the utilization of the molecular allergen analysis (MAA) for diagnosis and management of cow milk protein allergy (CMPA). RECENT FINDINGS: Cow milk proteins are among the most common food allergens in IgE- and non-IgE-mediated food allergic disorders in children. Most individuals with CMPA are sensitized to both caseins and whey proteins. Caseins are more resistant to high temperatures compared to whey proteins. MAA is not superior to the conventional diagnostic tests based on the whole allergen extracts for diagnosis of CMPA. However, MAA can be useful in diagnosing tolerance to extensively heated milk proteins in baked foods. Children with CMPA and high levels of casein IgE are less likely to tolerate baked milk compared to children with low levels of casein IgE. Specific IgE-binding patterns to casein and betalactoglobulin peptides may predict the natural course of CMPA and differentiate subjects who are more likely to develop CMPA at a younger age versus those with a more persistent CMPA. Specific IgE-binding patterns to casein and beta-lactoglobulin peptides may also predict response to milk OITand identify patientsmost likely to benefit fromOIT.
[Mh] Termos MeSH primário: Alérgenos/análise
Hipersensibilidade a Leite/diagnóstico
Proteínas do Leite/análise
[Mh] Termos MeSH secundário: Animais
Dessensibilização Imunológica
Esofagite Eosinofílica/imunologia
Seres Humanos
Imunoglobulina E/imunologia
Leite/imunologia
Hipersensibilidade a Leite/imunologia
Hipersensibilidade a Leite/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Allergens); 0 (Milk Proteins); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE
[do] DOI:10.1007/s11882-017-0716-z


  10 / 2092 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
Texto completo
[PMID]:28542713
[Au] Autor:Osborn DA; Sinn JK; Jones LJ
[Ad] Endereço:Central Clinical School, Discipline of Obstetrics, Gynaecology and Neonatology, University of Sydney, Sydney, NSW, Australia, 2050.
[Ti] Título:WITHDRAWN: Infant formulas containing hydrolysed protein for prevention of allergic disease and food allergy.
[So] Source:Cochrane Database Syst Rev;5:CD003664, 2017 05 25.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Allergy is common and may be associated with foods, including cow's milk formula (CMF). Formulas containing hydrolysed proteins have been used to treat infants with allergy. However, it is unclear whether hydrolysed formulas can be advocated for prevention of allergy in infants. OBJECTIVES: To compare effects on allergy and food allergy when infants are fed a hydrolysed formula versus CMF or human breast milk. If hydrolysed formulas are effective, to determine what type of hydrolysed formula is most effective, including extensively or partially hydrolysed formula (EHF/PHF). To determine which infants at low or high risk of allergy and which infants receiving early, short-term or prolonged formula feeding may benefit from hydrolysed formulas. SEARCH METHODS: We used the standard search strategy of the Cochrane Neonatal Review Group supplemented by cross referencing of previous reviews and publications (updated August 2016). SELECTION CRITERIA: We searched for randomised and quasi-randomised trials that compared use of a hydrolysed formula versus human milk or CMF. Trials with ≥ 80% follow-up of participants were eligible for inclusion. DATA COLLECTION AND ANALYSIS: We independently assessed eligibility of studies for inclusion, methodological quality and data extraction. Primary outcomes included clinical allergy, specific allergy and food allergy. We conducted meta-analysis using a fixed-effect (FE) model. MAIN RESULTS: Two studies assessed the effect of three to four days' infant supplementation with an EHF whilst in hospital after birth versus pasteurised human milk feed. Results showed no difference in infant allergy or childhood cow's milk allergy (CMA). No eligible trials compared prolonged hydrolysed formula versus human milk feeding.Two studies assessed the effect of three to four days infant supplementation with an EHF versus a CMF. One large quasi-random study reported a reduction in infant CMA of borderline significance among low-risk infants (risk ratio (RR) 0.62, 95% confidence interval (CI) 0.38 to 1.00).Prolonged infant feeding with a hydrolysed formula compared with a CMF was associated with a reduction in infant allergy (eight studies, 2852 infants; FE RR 0.82, 95% CI 0.72 to 0.95; risk difference (RD) -0.04, 95% CI -0.08 to -0.01; number needed to treat for an additional beneficial outcome (NNTB) 25, 95% CI 12.5 to 100) and infant CMA (two studies, 405 infants; FE RR 0.38, 95% CI 0.16 to 0.86). We had substantial methodological concerns regarding studies and concerns regarding publication bias, as substantial numbers of studies including those in high-risk infants have not comprehensively reported allergy outcomes (GRADE quality of evidence 'very low').Prolonged infant feeding with a hydrolysed formula compared with a CMF was not associated with a difference in childhood allergy and led to no differences in specific allergy, including infant and childhood asthma, eczema and rhinitis and infant food allergy. Many of the analyses assessing specific allergy are underpowered.Subroup analyses showed that infant allergy was reduced in studies that enrolled infants at high risk of allergy who used a hydrolysed formula compared with a CMF; used a PHF compared with a CMF; used prolonged and exclusive feeding of a hydrolysed formula compared with a CMF; and used a partially hydrolysed whey formula compared with a CMF. Studies that enrolled infants at high risk of allergy; used a PHF compared with a CMF; used prolonged and exclusive feeding of a hydrolysed formula compared with a CMF; and used a partially hydrolysed whey formula compared with a CMF found a reduction in infant CMA. AUTHORS' CONCLUSIONS: We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergy. Very low-quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA.In infants at high risk of allergy not exclusively breast fed, very low-quality evidence suggests that prolonged hydrolysed formula feeding compared with CMF feeding reduces infant allergy and infant CMA. Studies have found no difference in childhood allergy and no difference in specific allergy, including infant and childhood asthma, eczema and rhinitis and infant food allergy.Very low-quality evidence shows that prolonged use of a partially hydrolysed formula compared with a CMF for partial or exclusive feeding was associated with a reduction in infant allergy incidence and CMA incidence, and that prolonged use of an EHF versus a PHF reduces infant food allergy.
[Mh] Termos MeSH primário: Proteínas na Dieta
Hipersensibilidade Alimentar/prevenção & controle
Fórmulas Infantis/química
[Mh] Termos MeSH secundário: Seres Humanos
Hidrólise
Lactente
Recém-Nascido
Hipersensibilidade a Leite/prevenção & controle
Leite Humano
Hidrolisados de Proteína/administração & dosagem
Ensaios Clínicos Controlados Aleatórios como Assunto
Sinapsinas
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Dietary Proteins); 0 (Protein Hydrolysates); 0 (Synapsins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD003664.pub5



página 1 de 210 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde