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[PMID]:27773603
[Au] Autor:van der Valk JP; Gerth van Wijk R; Baumert JL; Nordlee JA; Vlieg-Boerstra BJ; de Groot H; Dubois AE; de Jong NW
[Ad] Endereço:Department of Internal Medicine, Allergology, Erasmus MC, Rotterdam, the Netherlands. Electronic address: j.p.m.vandervalk@erasmusmc.nl.
[Ti] Título:Threshold dose distribution and eliciting dose of cashew nut allergy.
[So] Source:Ann Allergy Asthma Immunol;117(6):712-714, 2016 12.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Anacardium/imunologia
Hipersensibilidade a Noz/imunologia
Nozes/imunologia
[Mh] Termos MeSH secundário: Adolescente
Alérgenos/imunologia
Feminino
Seguimentos
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Allergens)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:28595954
[Au] Autor:Javed B; Padfield P; Sperrin M; Simpson A; Mills ENC
[Ad] Endereço:Manchester Institute of Biotechnology, Manchester M17DN, UK; Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Manchester M17DN, UK.
[Ti] Título:A protocol for a systematic review to identify allergenic tree nuts and the molecules responsible for their allergenic properties.
[So] Source:Food Chem Toxicol;106(Pt A):411-416, 2017 Aug.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Food regulations require that tree nuts and derived ingredients are included on food labels in order to help individuals with IgE-mediated allergies to avoid them. However, there is no consensus regarding which tree nut species should be included in this definition and specified on food labels. Allergen detection methods used for monitoring foods target allergen molecules, but it not clear which are the most relevant molecules to choose. A modified population-exposure-comparators-outcome (PECO) approach has been developed to systematically review the evidence regarding (1) which allergenic tree nuts should be included in food allergen labelling lists and (2) which are the clinically relevant allergens which should be used as analytical targets. A search strategy and criteria against which the evidence will be evaluated have been developed. The resulting evidence will be used to rank tree nuts with regards their ability to cause IgE-mediated allergies, and allergen molecules regarding their capacity to elicit an allergic reaction. The results of the systematic review will enable risk assessors and managers to identify tree nut species that should be included in food allergen labelling lists and ensure analytical methods for determination of allergens in foods are targeting appropriate molecules.
[Mh] Termos MeSH primário: Hipersensibilidade a Noz/diagnóstico
Nozes/imunologia
[Mh] Termos MeSH secundário: Alérgenos/imunologia
Protocolos Clínicos
Seres Humanos
Imunoglobulina E/imunologia
Hipersensibilidade a Noz/etiologia
Hipersensibilidade a Noz/imunologia
Nozes/efeitos adversos
Nozes/química
Projetos Piloto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE


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[PMID]:28359600
[Au] Autor:Couch C; Franxman T; Greenhawt M
[Ad] Endereço:Division of Allergy and Clinical Immunology, The University of Michigan Medical School, Ann Arbor, Michigan; Allergy Asthma Clinic, Ltd, Phoenix, Arizona.
[Ti] Título:Characteristics of tree nut challenges in tree nut allergic and tree nut sensitized individuals.
[So] Source:Ann Allergy Asthma Immunol;118(5):591-596.e3, 2017 May.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Characteristics and outcomes of tree nut (TN) oral food challenges (OFCs) in patients with TN allergy or sensitization alone are poorly studied. OBJECTIVE: To determine the relation between TN sensitization levels and OFC outcomes. METHODS: Open TN OFCs performed from 2007 through 2015 at a referral center were analyzed to compare outcome based on skin prick test (SPT) wheal size, food-specific immunoglobulin E (sIgE), peanut co-allergy, and TN sensitization only vs TN allergy with sensitization to other TNs. Delayed OFC was defined as longer than 12 months from the time of an sIgE level lower than 2 kUA/L. RESULTS: Overall passage rate was 86% for 156 TN OFCs in 109 patients (54 almond, 28 cashew, 27 walnut, 18 hazelnut, 14 pecan, 13 pistachio, and 2 Brazil nut). Passage rates were 76% (n = 67) in patients with a history of TN allergy who were challenged to another TN to which they were sensitized and 91% (n = 65) in those with TN sensitization only (mean sIgE 1.53 kUA/L; range 0.35-9.14). Passage rates were 89% (n = 110 of 124) for a TN sIgE level lower than 2 kUA/L and 69% (11 of 16) for a TN sIgE level of at least 2 kUA/L. In 44 challenges in patients with peanut allergy and TN co-sensitization, the TN OFC passage rate was 96%. In 41 TN OFCs with a TN SPT wheal size of at least 3 mm, 61% passed, with a mean wheal size of 4.8 mm (range 3-11) in those passing vs 9 mm (range 3-20) in those failing. CONCLUSION: TN challenges are frequently passed in patients with TN sensitization with or without a history of TN reactivity despite a TN SPT wheal of at least 3 mm or a TN sIgE level of at least 2 kUA/L. Nearly all patients with peanut allergy and TN co-sensitization passed the TN challenge, questioning the clinical relevance of "co-allergy."
[Mh] Termos MeSH primário: Alérgenos/imunologia
Hipersensibilidade a Noz/diagnóstico
Hipersensibilidade a Noz/imunologia
Nozes/efeitos adversos
[Mh] Termos MeSH secundário: Alérgenos/classificação
Especificidade de Anticorpos/imunologia
Criança
Pré-Escolar
Comorbidade
Feminino
Seres Humanos
Imunização
Imunoglobulina E/sangue
Imunoglobulina E/imunologia
Masculino
Fenótipo
Estudos Retrospectivos
Testes Cutâneos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE


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[PMID]:28211344
[Au] Autor:González-Mancebo E; Alonso Díaz de Durana MD; García Estringana Y; Meléndez Baltanás A; Rodriguez-Alvarez M; de la Hoz Caballer B; Del Prado N; Fernández-Rivas M
[Ad] Endereço:Allergy Department, Hospital Universitario de Fuenlabrada, Madrid, Spain.
[Ti] Título:Validation of Recipes for Double-Blind Placebo-Controlled Challenges With Milk, Egg White, and Hazelnut.
[So] Source:J Investig Allergol Clin Immunol;27(1):40-45, 2017.
[Is] ISSN:1018-9068
[Cp] País de publicação:Spain
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The double-blind, placebo-controlled food challenge (DBPCFC) is considered the definitive diagnostic test for food allergy. Nevertheless, validated recipes for masking the foods are scarce, have not been standardized, and differ between centers. Sensory evaluation techniques such as the triangle test are necessary to validate the recipes used for DBPCFC. METHODS: We developed 3 recipes for use in DBPCFC with milk, egg white, and hazelnut and used the triangle test to validate them in a 2-phase study in which 197 volunteers participated. In each phase, participants tried 3 samples (2 active-1 placebo or 2 placebo-1 active) and had to identify the odd one. In phase 1, the 3 samples were given simultaneously, whereas in phase 2, the 3 samples of foods that failed validation in phase 1 were given sequentially. A visual analog scale (VAS) ranging from 1 to 10 was used to evaluate how much participants liked the recipes. RESULTS: In phase 1, the egg white recipe was validated (n=89 volunteers, 38.9% found the odd sample, P=.16). Milk and hazelnut recipes were validated in phase 2 (for both foods, n=30 participants, 36.7% found the odd sample, P=.36). Median VAS scores for the 3 recipes ranged from 6.6 to 9.7. CONCLUSIONS: We used sensory testing to validate milk, egg white, and hazelnut recipes for use in DBPCFC. The validated recipes are easy to prepare in a clinical setting, provide the equivalent of 1 serving dose, and were liked by most participants.
[Mh] Termos MeSH primário: Corylus
Hipersensibilidade a Ovo/diagnóstico
Proteínas do Ovo/administração & dosagem
Testes Imunológicos
Hipersensibilidade a Leite/diagnóstico
Proteínas do Leite/administração & dosagem
Hipersensibilidade a Noz/diagnóstico
Preparações de Plantas/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Culinária
Corylus/efeitos adversos
Corylus/imunologia
Método Duplo-Cego
Hipersensibilidade a Ovo/imunologia
Proteínas do Ovo/efeitos adversos
Proteínas do Ovo/imunologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Hipersensibilidade a Leite/imunologia
Proteínas do Leite/efeitos adversos
Proteínas do Leite/imunologia
Hipersensibilidade a Noz/imunologia
Satisfação do Paciente
Preparações de Plantas/efeitos adversos
Preparações de Plantas/imunologia
Valor Preditivo dos Testes
Reprodutibilidade dos Testes
Sensação
Espanha
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Egg Proteins); 0 (Milk Proteins); 0 (Plant Preparations)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE
[do] DOI:10.18176/jiaci.0084


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[PMID]:28110058
[Au] Autor:Blankestijn MA; Remington BC; Houben GF; Baumert JL; Knulst AC; Blom WM; Klemans RJ; Taylor SL
[Ad] Endereço:Department of Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: m.a.blankestijn@umcutrecht.nl.
[Ti] Título:Threshold Dose Distribution in Walnut Allergy.
[So] Source:J Allergy Clin Immunol Pract;5(2):376-380, 2017 Mar - Apr.
[Is] ISSN:2213-2201
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In food allergy, eliciting doses (EDs) of foods on a population level can improve risk management and labeling strategies for the food industry and regulatory authorities. Previously, data available for walnut were unsuitable to determine EDs. OBJECTIVE: The objective of this study was to determine EDs for walnut allergic adults and to compare with previously established threshold data for peanut and tree nuts. METHODS: Prospectively, adult subjects with a suspected walnut allergy underwent a low-dose double-blind, placebo-controlled food challenge. Individual no observed and lowest observed adverse effect levels were determined and log-normal, log-logistic, and Weibull models were fit to the data. Estimated ED values were calculated for the ED ED , and ED , the dose respectively predicted to provoke an allergic reaction in 5%, 10%, and 50% of the walnut allergic population. RESULTS: Fifty-seven subjects were challenged and 33 subjects were confirmed to be walnut allergic. Objective symptoms occurred in 20 of the positive challenges (61%). The cumulative EDs in the distribution models ranged from 3.1 to 4.1 mg for the ED , from 10.6 to 14.6 mg walnut protein for the ED , and from 590 to 625 mg of walnut protein for the ED . CONCLUSIONS: Our data indicate that population EDs for walnut are slightly higher compared with those for peanut and hazelnut allergy. Currently available data indicate that the ED values for hazelnut could be used as a conservative temporary placeholder when implementing risk management strategies for other tree nuts where little or no food challenge data are available.
[Mh] Termos MeSH primário: Alérgenos/imunologia
Juglans/imunologia
Hipersensibilidade a Noz/dietoterapia
Hipersensibilidade a Noz/diagnóstico
[Mh] Termos MeSH secundário: Administração Oral
Adulto
Feminino
Rotulagem de Alimentos
Seres Humanos
Imunização
Masculino
Estudos Prospectivos
Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170123
[St] Status:MEDLINE


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[PMID]:27966914
[Au] Autor:Mattison CP; Grimm CC; Li Y; Chial HJ; McCaslin DR; Chung SY; Bren-Mattison Y; Wasserman RL
[Ad] Endereço:Southern Regional Research Center, FPSQ, ARS, U.S. Department of Agriculture , 1100 Robert E. Lee Boulevard, New Orleans, Louisiana 70124, United States.
[Ti] Título:Identification and Characterization of Ana o 3 Modifications on Arginine-111 Residue in Heated Cashew Nuts.
[So] Source:J Agric Food Chem;65(2):411-420, 2017 Jan 18.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Raw and roasted cashew nut extracts were evaluated for protein modifications by mass spectrometry. Independent modifications on the Arg-111 residue of Ana o 3 were observed in roasted but not raw cashew nuts. The mass changes of 72.0064 or 53.9529 Da are consistent with the formation of carboxyethyl and hydroimidazolone modifications at the Arg-111 residue. These same modifications were observed in Ana o 3 purified from roasted but not raw cashew nuts, albeit at a relatively low occurrence. Circular dichroism indicated that Ana o 3 purified from raw and roasted cashew nuts had similar secondary structure, and dynamic light scattering analysis indicated there was no observable difference in particle size. The stability of Ana o 3 purified from raw and roasted cashew nuts to trypsin was similar in the absence of or following treatment with a reducing agent. Only minor differences in IgE binding to Ana o 3 were observed by ELISA among a cohort of cashew-allergic patient sera.
[Mh] Termos MeSH primário: Anacardium/química
Antígenos de Plantas/química
Arginina/química
Manipulação de Alimentos/métodos
Proteínas de Plantas/química
[Mh] Termos MeSH secundário: Antígenos de Plantas/isolamento & purificação
Antígenos de Plantas/metabolismo
Dicroísmo Circular
Difusão Dinâmica da Luz
Ensaio de Imunoadsorção Enzimática
Calefação
Seres Humanos
Imidazóis/química
Soros Imunes
Imunoglobulina E/metabolismo
Hipersensibilidade a Noz/imunologia
Nozes/química
Tamanho da Partícula
Proteínas de Plantas/isolamento & purificação
Proteínas de Plantas/metabolismo
Conformação Proteica
Tripsina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ana o 3 protein, Anacardium occidentale); 0 (Antigens, Plant); 0 (Imidazoles); 0 (Immune Sera); 0 (Plant Proteins); 0 (imidazolone); 37341-29-0 (Immunoglobulin E); 94ZLA3W45F (Arginine); EC 3.4.21.4 (Trypsin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170502
[Lr] Data última revisão:
170502
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161215
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b04134


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[PMID]:27936684
[Au] Autor:Zhang YZ; Du WX; Fan Y; Yi J; Lyu SC; Nadeau KC; Thomas AL; McHugh T
[Ad] Endereço:Western Regional Research Center, Pacific West Area, Agricultural Research Service, U.S. Department of Agriculture , 800 Buchanan Street, Albany, California 94710, United States.
[Ti] Título:Purification and Characterization of a Black Walnut (Juglans nigra) Allergen, Jug n 4.
[So] Source:J Agric Food Chem;65(2):454-462, 2017 Jan 18.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tree nuts as a group cause a significant number of fatal anaphylactic reactions to foods. Walnuts (Juglans spp.) are one of the leading causes of allergic reactions to tree nuts in the U.S. and Japan. The purpose of this study was to purify and characterize potential food allergens from black walnut. Here, we report the isolation of the black walnuts allergen Jug n 4 (an 11S globulin) by ammonium sulfate precipitation, hydrophobic interaction, and size exclusion chromatography. Reducing SDS-PAGE analysis indicated that purified Jug n 4 consists of three major bands. N-Terminal sequencing data of these bands indicated that they were the results of a post-transcriptional protease cleavage of the mature protein at a site that consists of a known conserved protease recognition motif, NGXEET. Western blot experiments revealed that 32% of the sera from 25 patients with double-blind, placebo-controlled clinical walnut allergy contained IgE antibodies that recognized Jug n 4, indicating that it is a walnut allergen. Identifying this and additional allergens may facilitate the understanding of the allergenicity of seed storage proteins in tree nuts and their cross-reactivity.
[Mh] Termos MeSH primário: Alérgenos/isolamento & purificação
Antígenos de Plantas/isolamento & purificação
Juglans/química
Hipersensibilidade a Noz/imunologia
Proteínas de Plantas/isolamento & purificação
[Mh] Termos MeSH secundário: Adolescente
Alérgenos/genética
Alérgenos/imunologia
Motivos de Aminoácidos
Antígenos de Plantas/genética
Antígenos de Plantas/imunologia
Precipitação Química
Criança
Cromatografia em Gel
Dicroísmo Circular
Eletroforese em Gel de Poliacrilamida
Seres Humanos
Soros Imunes
Juglans/imunologia
Proteínas de Plantas/genética
Proteínas de Plantas/imunologia
Processamento Pós-Transcricional do RNA
Adulto Jovem
[Pt] Tipo de publicação:CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Antigens, Plant); 0 (Immune Sera); 0 (Jug n 4 allergen, Juglans nigra); 0 (Plant Proteins); 0 (legumin protein, plant)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170502
[Lr] Data última revisão:
170502
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b04387


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[PMID]:27859359
[Au] Autor:Kleine-Tebbe J; Hamilton RG
[Ad] Endereço:Allergy & Asthma Center Westend, Outpatient Clinic Hanf, Ackermann & Kleine-Tebbe, Berlin, Germany.
[Ti] Título:Cashew allergy, 2S albumins, and risk predictions based on IgE antibody levels.
[So] Source:Allergy;72(4):515-518, 2017 04.
[Is] ISSN:1398-9995
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Mh] Termos MeSH primário: Albuminas
Anacardium/imunologia
[Mh] Termos MeSH secundário: Albuminas 2S de Plantas/imunologia
Alérgenos/imunologia
Antígenos de Plantas/imunologia
Seres Humanos
Imunoglobulina E/imunologia
Hipersensibilidade a Noz/imunologia
Proteínas de Plantas/imunologia
[Pt] Tipo de publicação:EDITORIAL; COMMENT
[Nm] Nome de substância:
0 (2S Albumins, Plant); 0 (Albumins); 0 (Allergens); 0 (Antigens, Plant); 0 (Plant Proteins); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE
[do] DOI:10.1111/all.13084


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[PMID]:27793601
[Au] Autor:Eigenmann PA; Lack G; Mazon A; Nieto A; Haddad D; Brough HA; Caubet JC
[Ad] Endereço:Pediatric Allergy Unit, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland. Electronic address: Philippe.Eigenmann@hcuge.ch.
[Ti] Título:Managing Nut Allergy: A Remaining Clinical Challenge.
[So] Source:J Allergy Clin Immunol Pract;5(2):296-300, 2017 Mar - Apr.
[Is] ISSN:2213-2201
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Peanut and tree nut allergies have become a public health problem over the last 2 decades. The diagnostic procedure relies on a suggestive history, as well as on evidence of sensitization (skin prick testing and/or specific IgE blood testing), followed in selected cases by a food challenge. Standard IgE tests may be positive to more than 1 nut, due to cross-reactivity (allergens common to several nuts) or cosensitivity (frequently associated positive test results without cross-reactivity). Thus, many patients with a peanut or a tree nut allergy avoid all nuts, relying on positive test results without clinical evidence of reactivity. In addition, coexisting pollen sensitivity may add to diagnostic uncertainty due to potential cross-reactivity between pollens and nuts. In this article, we discuss challenges in diagnosis and clinical management of peanut and tree nut allergy related to cross-reactivity and cosensitization, as well as the avoidance of nuts tested positive to reduce the risk of reactions by cross-contamination. Studies to provide more accurate characterization of genuine clinically relevant cross-reactivity or cosensitivity to multiple nuts are needed.
[Mh] Termos MeSH primário: Alérgenos/imunologia
Arachis/imunologia
Hipersensibilidade a Noz/dietoterapia
Hipersensibilidade a Noz/diagnóstico
Nozes/imunologia
Hipersensibilidade a Amendoim/dietoterapia
Hipersensibilidade a Amendoim/diagnóstico
[Mh] Termos MeSH secundário: Administração Oral
Adulto
Criança
Reações Cruzadas
Gerenciamento Clínico
Seres Humanos
Imunização
Imunoglobulina E/sangue
Anamnese
Testes Cutâneos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE


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[PMID]:27726958
[Au] Autor:Kim MN; Lee KE; Hong JY; Kim KW; Kim KE; Sohn MH; Park JW
[Ad] Endereço:Department of Pediatrics, Severance Hospital, Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.
[Ti] Título:IgE cross-reactivity of peanut with walnut and soybean in children with food allergy.
[So] Source:Allergol Immunopathol (Madr);44(6):524-530, 2016 Nov - Dec.
[Is] ISSN:1578-1267
[Cp] País de publicação:Spain
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Peanut allergies are common and can be life-threating for sensitised individuals. Peanut allergens share significant amino acid homology with those of other legumes and tree nuts, but their cross-reactivity still remains unclear. OBJECTIVE: We sought to determine the clinical significance of the cross-reactivity of peanut allergens with those of walnut and soybean. METHODS: Pooled sera from eight subjects with both peanut and walnut specific IgE were investigated in an inhibition test. After the sera were incubated with either peanut or walnut protein extracts, the quantity of IgE antibodies against the peanut and walnut was measured using an immunoCAP test. Likewise, pooled sera from 18 subjects with both peanut and soybean specific IgE antibodies were incubated with either peanut or soybean protein extracts and evaluated with a peanut and soybean immunoCAP test. SDS-PAGE and immunoblotting were also performed with peanut, walnut and soybean protein extracts and relevant sera. RESULTS: Peanut specific IgE was inhibited up to 20% and 26% by walnut and soybean protein extracts, respectively. In reverse, walnut and soybean specific IgE were inhibited up to 21% and 23% by peanut protein extracts, respectively. In the immunoblot analysis, pooled serum from the subjects with peanut specific IgE antibodies reacted with walnut protein extracts significantly. CONCLUSION: Although the clinical significance of the cross-reactivity of peanut specific IgE with walnut and soybean protein extracts has not been established, we believe that individuals who are allergic to peanuts need to be cautious about consuming walnuts and soybeans.
[Mh] Termos MeSH primário: Reações Cruzadas
Hipersensibilidade a Noz/imunologia
[Mh] Termos MeSH secundário: Antígenos de Plantas/imunologia
Arachis/imunologia
Ligação Competitiva
Criança
Pré-Escolar
Feminino
Seres Humanos
Imunoglobulina E/sangue
Lactente
Recém-Nascido
Juglans/imunologia
Masculino
Feijão de Soja/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Plant); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161012
[St] Status:MEDLINE



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