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[PMID]:27477514
[Au] Autor:Stamatiades EG; Tremblay ME; Bohm M; Crozet L; Bisht K; Kao D; Coelho C; Fan X; Yewdell WT; Davidson A; Heeger PS; Diebold S; Nimmerjahn F; Geissmann F
[Ad] Endereço:Immunology Program and Ludwig Center, Memorial Sloan Kettering Cancer Center, 417 East 68th Street, New York, NY 10065, USA.
[Ti] Título:Immune Monitoring of Trans-endothelial Transport by Kidney-Resident Macrophages.
[So] Source:Cell;166(4):991-1003, 2016 Aug 11.
[Is] ISSN:1097-4172
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Small immune complexes cause type III hypersensitivity reactions that frequently result in tissue injury. The responsible mechanisms, however, remain unclear and differ depending on target organs. Here, we identify a kidney-specific anatomical and functional unit, formed by resident macrophages and peritubular capillary endothelial cells, which monitors the transport of proteins and particles ranging from 20 to 700 kDa or 10 to 200 nm into the kidney interstitium. Kidney-resident macrophages detect and scavenge circulating immune complexes "pumped" into the interstitium via trans-endothelial transport and trigger a FcγRIV-dependent inflammatory response and the recruitment of monocytes and neutrophils. In addition, FcγRIV and TLR pathways synergistically "super-activate" kidney macrophages when immune complexes contain a nucleic acid. These data identify a physiological function of tissue-resident kidney macrophages and a basic mechanism by which they initiate the inflammatory response to small immune complexes in the kidney.
[Mh] Termos MeSH primário: Doenças do Complexo Imune/imunologia
Rim/citologia
Rim/imunologia
Macrófagos/imunologia
[Mh] Termos MeSH secundário: Animais
Complexo Antígeno-Anticorpo
Células Endoteliais
Macrófagos/citologia
Camundongos Endogâmicos C57BL
Microscopia Imunoeletrônica
Monócitos/citologia
Monócitos/imunologia
Neutrófilos/citologia
Neutrófilos/imunologia
Receptores de IgG/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antigen-Antibody Complex); 0 (Fcgr4 protein, mouse); 0 (Receptors, IgG)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160802
[St] Status:MEDLINE


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[PMID]:27130149
[Au] Autor:Motiram Kakalij R; Tejaswini G; Patil MA; Dinesh Kumar B; Diwan PV
[Ad] Endereço:Department of Pharmacology and Toxicology, School of Pharmacy, Anurag Group of Institutions, Hyderabad, Andhra Pradesh, 500 088, India.
[Ti] Título:Vanillic Acid Ameliorates Cationic Bovine Serum Albumin Induced Immune Complex Glomerulonephritis in BALB/c Mice.
[So] Source:Drug Dev Res;77(4):171-9, 2016 Jun.
[Is] ISSN:1098-2299
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Preclinical Research Vanillic acid (VA) is a dihydroxybenzoic acid derivative widely used as a flavoring agent. It has chemopreventive effects on experimentally-induced carcinogenesis and in ulcerative colitis. The object of the present study was to investigate the effects of VA, alone and in combination with methylprednisolone (MP), on cationic bovine serum albumin (cBSA induced immune-complex glomerulonephritis in female BALB/c mice. Pre-immunization was carried out with cBSA in BALB/c mice and repeated (cBSA, 13 mg/kg, 3 times/week, i.v.) for 6 weeks to induce glomerulonephritis which was confirmed by the presence of severe proteinuria. The effect of VA (50, 100, and 200 mg/kg, p.o.) and its combination with MP (12.5 mg/kg, p.o.) was assessed in the nephrotic disease model. Treatment with VA decreased inflammatory nephrotic injury as evidenced by decreased proteinuria, serum creatinine, blood urea nitrogen, serum IgG1 and TNF-α levels. Co-administration of VA with MP showed an improvement in the immunohistochemistry of glomerular nephrin and podocin. The present results indicate that VA has a nephroprotective effect in the management of autoimmune nephritis. Drug Dev Res 77 : 171-179, 2016. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Glomerulonefrite/tratamento farmacológico
Doenças do Complexo Imune/tratamento farmacológico
Metilprednisolona/farmacologia
Ácido Vanílico/farmacologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Quimioterapia Combinada
Feminino
Glomerulonefrite/fisiopatologia
Doenças do Complexo Imune/fisiopatologia
Imuno-Histoquímica
Peptídeos e Proteínas de Sinalização Intracelular/metabolismo
Proteínas de Membrana/metabolismo
Metilprednisolona/administração & dosagem
Camundongos
Camundongos Endogâmicos BALB C
Soroalbumina Bovina/administração & dosagem
Resultado do Tratamento
Ácido Vanílico/administração & dosagem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Intracellular Signaling Peptides and Proteins); 0 (Membrane Proteins); 0 (NPHS2 protein); 0 (nephrin); 27432CM55Q (Serum Albumin, Bovine); GM8Q3JM2Y8 (Vanillic Acid); X4W7ZR7023 (Methylprednisolone)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160501
[St] Status:MEDLINE
[do] DOI:10.1002/ddr.21304


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[PMID]:27118389
[Au] Autor:Lopalco G; Rigante D; Venerito V; Emmi G; Anelli MG; Lapadula G; Iannone F; Cantarini L
[Ad] Endereço:Interdisciplinary Department of Medicine, Rheumatology Unit, University of Bari, Bari, Italy.
[Ti] Título:Management of Small Vessel Vasculitides.
[So] Source:Curr Rheumatol Rep;18(6):36, 2016 Jun.
[Is] ISSN:1534-6307
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Inflammation mediated by cells of the immune system and necrosis are the most striking features observed at the histologic level in patients with vasculitides, clinical entities classified according to pathologic findings involving different organs, to etiology, or to size of vessels involved. Small vessel vasculitides (SVV) are a peculiar group of systemic disorders electively involving small intraparenchymal arteries, arterioles, capillaries, or venules and leading to different levels of vascular obstruction, tissue ischemia and risk of infarction; they can be divided into anti-neutrophil cytoplasmic antibody-associated vasculitides and immune complex vasculitides. Despite the significant advances in understanding the whole disease process and pathophysiology of SVV, strong efforts are still needed to draft, share and spread guidelines in the therapeutic management of these protean disorders. After an accurate evaluation of different open or double-blind trials and cohort studies in this review, we analyze the actual medical tools suggested for treating granulomatosis with polyangiitis, microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis, Henoch-Schönlein purpura, cryoglobulinemic vasculitis, anti-glomerular basement membrane disease and hypocomplementemic urticarial vasculitis.
[Mh] Termos MeSH primário: Doenças do Complexo Imune/tratamento farmacológico
Vasculite Sistêmica/tratamento farmacológico
[Mh] Termos MeSH secundário: Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos/tratamento farmacológico
Produtos Biológicos/uso terapêutico
Seres Humanos
Imunossupressores/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biological Products); 0 (Immunosuppressive Agents)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160428
[St] Status:MEDLINE
[do] DOI:10.1007/s11926-016-0580-1


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[PMID]:26996341
[Au] Autor:Dalvin LA; Fervenza FC; Sethi S; Pulido JS
[Ad] Endereço:Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota.
[Ti] Título:Manifestations of Complement-Mediated and Immune Complex-Mediated Membranoproliferative Glomerulonephritis: A Comparative Consecutive Series.
[So] Source:Ophthalmology;123(7):1588-94, 2016 Jul.
[Is] ISSN:1549-4713
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Membranoproliferative glomerulonephritis (MPGN) recently was reclassified to reflect the underlying cause as a complement-mediated and immune complex-mediated disease. This classification is based on renal biopsy immunofluorescence examination, making the former electron-microscopy classification obsolete. In this report, we describe related eye findings in patients with MPGN based on the new classification. DESIGN: Retrospective case series. PARTICIPANTS: All Mayo Clinic Rochester patients with pathology-confirmed complement- and immune complex-mediated MPGN who had available ophthalmology records from 1997 through 2014 were included in this study. METHODS: The medical and pathologic records of patients with MPGN and eye examination results were reviewed from years 1997 through 2014. MAIN OUTCOME MEASURES: The number of patients and the number of eyes with MPGN-related pathologic features were examined. Visual acuity also was considered. RESULTS: There were 23 patients with complement-mediated MPGN and available eye examination results. Of these, 9 patients (39%) and 17 eyes (37%) had retinal pathologic features that likely were related to the same underlying pathophysiologic process as their renal disease. Five patients (22%) and 6 eyes (13%) had significant vision loss. There were 23 patients with immune complex-mediated MPGN and available eye examination results. Only 2 (9%) of these patients (4 eyes) had retinal pathologic features that potentially could be related to the same underlying pathophysiologic process as their renal disease, and neither had vision loss. CONCLUSIONS: Retinal abnormalities are more prominent among patients with complement-mediated MPGN when compared with patients with immune complex-mediated MPGN. It is critical for ophthalmologists to recognize the updated MPGN classification system, and all patients with complement-mediated MPGN require screening eye examinations.
[Mh] Termos MeSH primário: Glomerulonefrite Membranoproliferativa/complicações
Doenças do Complexo Imune/complicações
Doenças Retinianas/patologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Glomerulonefrite Membranoproliferativa/classificação
Glomerulonefrite Membranoproliferativa/patologia
Seres Humanos
Masculino
Meia-Idade
Doenças Retinianas/fisiopatologia
Drusas Retinianas/patologia
Epitélio Pigmentado da Retina/patologia
Estudos Retrospectivos
Tomografia de Coerência Óptica
Acuidade Visual/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170623
[Lr] Data última revisão:
170623
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160322
[St] Status:MEDLINE


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[PMID]:26846787
[Au] Autor:Kawasaki Y; Kanno S; Ono A; Suzuki Y; Ohara S; Sato M; Suyama K; Hashimoto K; Hosoya M
[Ad] Endereço:Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima City, Fukushima, 960-1295, Japan. kyuki@fmu.ac.jp.
[Ti] Título:Differences in clinical findings, pathology, and outcomes between C3 glomerulonephritis and membranoproliferative glomerulonephritis.
[So] Source:Pediatr Nephrol;31(7):1091-9, 2016 07.
[Is] ISSN:1432-198X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To clarify the clinical manifestations of pediatric complement component C3 glomerulonephritis (C3GN), we retrospectively evaluated differences in the clinicopathological findings and prognosis between C3GN and immune-complex-mediated membranoproliferative glomerulonephritis (IC-MPGN). METHODS: Thirty-seven patients diagnosed with "idiopathic MPGN" were enrolled in this retrospective study. The patients were divided into two groups, with Group 1 consisting of 19 patients diagnosed with IC-MPGN and Group 2 consisting of 18 patients diagnosed with C3GN. The clinical findings and the prognosis were investigated for both groups. RESULTS: Thirteen patients in Group 2 were identified by mandatory annual school screening for urinary abnormalities. The incidence of macro-hematuria and the frequency of low serum C4 values were lower in Group 2 patients than in Group 1 patients. At the time of the second renal biopsy, urinary protein excretion, incidence of hematuria, frequency of low serum C3 values, and scores for mesangial proliferation, glomerular sclerosis, and interstitial fibrosis were higher in Group 2 patients than in Group 1 patients. At the most recent follow-up examination, the number of patients categorized as non-responding or with end-stage renal disease was higher in Group 2 patients than in Group 1 patients. CONCLUSIONS: Our results suggest that the treatment response and prognosis of patients with C3GN are worse than those of patients with IC-mediated MPGN. Therefore, in the clinical context regarding treatment options and prognosis, it may be useful to classify idiopathic MPGN as C3GN or IC-MPGN. In addition, long-term follow-up of C3GN is necessary.
[Mh] Termos MeSH primário: Complemento C3
Glomerulonefrite Membranoproliferativa/patologia
Doenças do Complexo Imune/patologia
[Mh] Termos MeSH secundário: Criança
Feminino
Glomerulonefrite Membranoproliferativa/epidemiologia
Glomerulonefrite Membranoproliferativa/imunologia
Seres Humanos
Doenças do Complexo Imune/epidemiologia
Doenças do Complexo Imune/imunologia
Imuno-Histoquímica
Incidência
Masculino
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Complement C3)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160206
[St] Status:MEDLINE
[do] DOI:10.1007/s00467-015-3307-z


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[PMID]:26802238
[Au] Autor:Li JL; Lim CH; Tay FW; Goh CC; Devi S; Malleret B; Lee B; Bakocevic N; Chong SZ; Evrard M; Tanizaki H; Lim HY; Russell B; Renia L; Zolezzi F; Poidinger M; Angeli V; St John AL; Harris JE; Tey HL; Tan SM; Kabashima K; Weninger W; Larbi A; Ng LG
[Ad] Endereço:Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore.
[Ti] Título:Neutrophils Self-Regulate Immune Complex-Mediated Cutaneous Inflammation through CXCL2.
[So] Source:J Invest Dermatol;136(2):416-24, 2016 Feb.
[Is] ISSN:1523-1747
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Deposition of immune complexes (ICs) in tissues triggers acute inflammatory pathology characterized by massive neutrophil influx leading to edema and hemorrhage, and is especially associated with vasculitis of the skin, but the mechanisms that regulate this type III hypersensitivity process remain poorly understood. Here, using a combination of multiphoton intravital microscopy and genomic approaches, we re-examined the cutaneous reverse passive Arthus reaction and observed that IC-activated neutrophils underwent transmigration, triggered further IC formation, and transported these ICs into the interstitium, whereas neutrophil depletion drastically reduced IC formation and ameliorated vascular leakage in vivo. Thereafter, we show that these neutrophils expressed high levels of CXCL2, which further amplified neutrophil recruitment and activation in an autocrine and/or paracrine manner. Notably, CXCL1 expression was restricted to tissue-resident cell types, but IC-activated neutrophils may also indirectly, via soluble factors, modulate macrophage CXCL1 expression. Consistent with their distinct cellular origins and localization, only neutralization of CXCL2 but not CXCL1 in the interstitium effectively reduced neutrophil recruitment. In summary, our study establishes that neutrophils are able to self-regulate their own recruitment and responses during IC-mediated inflammation through a CXCL2-driven feed forward loop.
[Mh] Termos MeSH primário: Complexo Antígeno-Anticorpo/imunologia
Quimiocina CXCL2/metabolismo
Dermatite/imunologia
Doenças do Complexo Imune/imunologia
Neutrófilos/imunologia
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Quimiocina CXCL2/imunologia
Dermatite/metabolismo
Modelos Animais de Doenças
Ensaio de Imunoadsorção Enzimática
Feminino
Doenças do Complexo Imune/fisiopatologia
Mediadores da Inflamação/metabolismo
Macrófagos/imunologia
Masculino
Mastócitos/imunologia
Camundongos
Camundongos Endogâmicos C57BL
Infiltração de Neutrófilos/imunologia
Neutrófilos/metabolismo
RNA Mensageiro/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antigen-Antibody Complex); 0 (CXCL2 protein, human); 0 (Chemokine CXCL2); 0 (Inflammation Mediators); 0 (RNA, Messenger)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160124
[Lr] Data última revisão:
160124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160124
[St] Status:MEDLINE


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[PMID]:26782673
[Au] Autor:Baqir M; Garrity JA; Vassallo R; Witzig TE; Ryu JH
[Ad] Endereço:Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address: baqir.misbah@mayo.edu.
[Ti] Título:Asthma and orbital immunoglobulin G4-related disease.
[So] Source:Ann Allergy Asthma Immunol;116(4):313-6, 2016 Apr.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: An association has been suggested between asthma and orbital immunoglobulin G4-related disease (IgG4-RD). OBJECTIVE: To explore this association, including asthma characteristics and risk factors. METHODS: A retrospective, computer-assisted search identified patients with orbital IgG4-RD seen at Mayo Clinic in Rochester, Minnesota from 1997 to 2014. Asthma prevalence and its related clinical and radiologic characteristics were studied. RESULTS: Thirty-one patients (17 men) with biopsy-proven orbital IgG4-RD were identified. Mean age at diagnosis was 54.3 years (SD 11.0 years). Median duration from onset of orbital symptoms to IgG4-RD diagnosis was 1.96 years (range 0.1-31.8 years). Twenty-two patients (71%) were not smokers, 6 (19%) were former smokers, and 3 (10%) were current smokers. Sixteen patients (52%) had asthma. Three patients had childhood asthma onset, and median age at asthma onset in the 7 patients with data available was 56 years (range 15-62 years). In this cohort, the most common findings at chest computed tomography were mediastinal and hilar lymphadenopathy (44%), linear scarring (20%), and nodules and bronchial wall thickening (16%). Bronchial wall thickening correlated with presence of asthma. Chronic sinusitis (94%) was most commonly associated with asthma. Serum IgG4 was markedly increased in patients with asthma (median 195.0 mg/dL, range 31.8-1,790.0 mg/dL) vs patients without asthma (median 78.9 mg/dL, range 7.7-166.0 mg/dL; P = .02). Treatment was commonly prednisone and then rituximab; rituximab helped control asthma in most cases. Two deaths were reported (median follow-up 4.2 years). CONCLUSION: Asthma is commonly associated with orbital IgG4-RD and generally manifests as adult-onset bronchial wall thickening seen at computed tomography, increased serum IgG4 levels, and good rituximab response.
[Mh] Termos MeSH primário: Asma/epidemiologia
Doenças do Complexo Imune/epidemiologia
Imunoglobulina G/metabolismo
Doenças Orbitárias/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Asma/tratamento farmacológico
Asma/mortalidade
Feminino
Seguimentos
Seres Humanos
Doenças do Complexo Imune/tratamento farmacológico
Doenças do Complexo Imune/mortalidade
Masculino
Meia-Idade
Doenças Orbitárias/tratamento farmacológico
Doenças Orbitárias/mortalidade
Prevalência
Estudos Retrospectivos
Rituximab/uso terapêutico
Análise de Sobrevida
Estados Unidos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G); 4F4X42SYQ6 (Rituximab)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160408
[Lr] Data última revisão:
160408
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160120
[St] Status:MEDLINE


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[PMID]:26754737
[Au] Autor:Alasfar S; Carter-Monroe N; Rosenberg AZ; Montgomery RA; Alachkar N
[Ad] Endereço:Department of Medicine, The Johns Hopkins University School of Medicine, 600 Wolfe Street. Brady 502, 21287, Baltimore, MD, USA. salasfa1@jhmi.edu.
[Ti] Título:Membranoproliferative glomerulonephritis recurrence after kidney transplantation: using the new classification.
[So] Source:BMC Nephrol;17:7, 2016 Jan 11.
[Is] ISSN:1471-2369
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Membranoproliferative glomerulonephritis (MPGN) is an uncommon glomerular disorder that may lead to end stage renal disease (ESRD). With new understanding of the disease pathogenesis, the classical classification as MPGN types I, II, III has changed. Data on post-transplant MPGN, in particular with the newly refined classification, is limited. We present our center's experience of MPGN after kidney transplantation using the new classification. METHODS: This is a retrospective study of 34 patients with ESRD due to MPGN who received 40 kidney transplants between 1994 and 2014. We reviewed the available biopsies' data using the new classification. We assessed post transplantation recurrence rate, risk factors of recurrence, the response to therapy and allografts' survival. RESULTS: Median time of follow up was 5.3 years (range 0.5-14 years). Using the new classification, we found that pre-transplant MPGN disease was due to immune complex-mediated glomerulonephritis (ICGN) in 89 % of cases and complement-mediated glomerulonephritis (CGN) in 11 %. Recurrence was detected in 18 transplants (45 %). Living related allografts (P = 0.045), preemptive transplantations (P = 0.018), low complement level (P = 0.006), and the presence of monoclonal gammopathy (P = 0.010) were associated with higher recurrence rate in ICGN cases. Half of the patients with recurrence lost their allografts. The use of ACEi/ARB was associated with a trend toward less allograft loss. CONCLUSIONS: MPGN recurs at a high rate after kidney transplantation. The risk of MPGN recurrence increases with preemptive transplantation, living related donation, low complement level, and the presence of monoclonal gammopathy. Recurrence of MPGN leads to allograft failure in half of the cases.
[Mh] Termos MeSH primário: Glomerulonefrite Membranoproliferativa/classificação
Glomerulonefrite Membranoproliferativa/cirurgia
Falência Renal Crônica/cirurgia
Transplante de Rim
[Mh] Termos MeSH secundário: Adolescente
Adulto
Antagonistas de Receptores de Angiotensina/uso terapêutico
Inibidores da Enzima Conversora de Angiotensina/uso terapêutico
Proteínas do Sistema Complemento/metabolismo
Feminino
Seguimentos
Glomerulonefrite Membranoproliferativa/etiologia
Glomerulonefrite Membranoproliferativa/terapia
Sobrevivência de Enxerto
Seres Humanos
Doenças do Complexo Imune/complicações
Falência Renal Crônica/etiologia
Doadores Vivos
Masculino
Meia-Idade
Paraproteinemias/complicações
Recidiva
Estudos Retrospectivos
Fatores de Risco
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiotensin Receptor Antagonists); 0 (Angiotensin-Converting Enzyme Inhibitors); 9007-36-7 (Complement System Proteins)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160113
[St] Status:MEDLINE
[do] DOI:10.1186/s12882-015-0219-x


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[PMID]:26683153
[Au] Autor:Rosetti F; Mayadas TN
[Ad] Endereço:Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
[Ti] Título:The many faces of Mac-1 in autoimmune disease.
[So] Source:Immunol Rev;269(1):175-93, 2016 Jan.
[Is] ISSN:1600-065X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mac-1 (CD11b/CD18) is a ß2 integrin classically regarded as a pro-inflammatory molecule because of its ability to promote phagocyte cytotoxic functions and enhance the function of several effector molecules such as FcγR, uPAR, and CD14. Nevertheless, recent reports have revealed that Mac-1 also plays significant immunoregulatory roles, and genetic variants in ITGAM, the gene that encodes CD11b, confer risk for the autoimmune disease systemic lupus erythematosus (SLE). This has renewed interest in the physiological roles of this integrin and raised new questions on how its seemingly opposing biological functions may be regulated. Here, we provide an overview of the CD18 integrins and how their activation may be regulated as this may shed light on how the opposing roles of Mac-1 may be elicited. We then discuss studies that exemplify Mac-1's pro-inflammatory versus regulatory roles particularly in the context of IgG immune complex-mediated inflammation. This includes a detailed examination of molecular mechanisms that could explain the risk-conferring effect of rs1143679, a single nucleotide non-synonymous Mac-1 polymorphism associated with SLE.
[Mh] Termos MeSH primário: Antígeno CD11b/metabolismo
Doenças do Complexo Imune/imunologia
Lúpus Eritematoso Sistêmico/imunologia
[Mh] Termos MeSH secundário: Animais
Antígeno CD11b/genética
Predisposição Genética para Doença
Seres Humanos
Imunomodulação
Fagocitose
Polimorfismo Genético
Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (CD11b Antigen); 0 (ITGAM protein, human)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151220
[St] Status:MEDLINE
[do] DOI:10.1111/imr.12373


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[PMID]:26616334
[Au] Autor:Hoorn EJ; Taams NE; Hurskainen T; Salih M; Weening JJ; Jonkman MF; Pas HH; Schreurs MW
[Ad] Endereço:Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands. Electronic address: e.j.hoorn@erasmusmc.nl.
[Ti] Título:Bullous Pemphigoid With a Dual Pattern of Glomerular Immune Complex Disease.
[So] Source:Am J Kidney Dis;67(2):302-6, 2016 Feb.
[Is] ISSN:1523-6838
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A 75-year-old man presented with a blistering skin disease and nephrotic syndrome. Bullous pemphigoid was diagnosed by linear immunoglobulin G (IgG) and C3 staining along the basement membrane zone of a skin biopsy specimen and by the presence of circulating IgG recognizing the 180-kDa bullous pemphigoid antigen (BP180; type XVII collagen). A kidney biopsy specimen showed endocapillary inflammation without crescents. Direct immunofluorescence showed strong IgG and C3 staining in a combined granular and linear pattern along the glomerular basement membrane. Electron microscopy showed subepithelial deposits. In serum, no antibodies against the Goodpasture antigen (type IV collagen) or phospholipase A2 receptor were detected. Indirect immunofluorescence studies using the patient's serum showed a strikingly linear but not granular IgG pattern along the epithelial basement membranes of monkey esophagus and kidney. Although type XVII collagen was recently identified in the glomerulus, the patient's serum did not produce a 180-kDa band on immunoblot of kidney tissue and still stained glomeruli of BP180 knockout mice by indirect immunofluorescence. The patient was treated with prednisone and azathioprine, which resulted in complete remission of skin and kidney manifestations. Although bullous pemphigoid has been reported previously in association with anti-glomerular basement membrane disease or membranous nephropathy, this case demonstrates both elements in 1 patient. This concurrence and the linear pattern on indirect immunofluorescence support the possibility of cross-reactive or parallel autoantibodies to basement membranes with a secondary membranous component.
[Mh] Termos MeSH primário: Glomerulonefrite/diagnóstico
Doenças do Complexo Imune/diagnóstico
Penfigoide Bolhoso/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Animais
Glomerulonefrite/complicações
Seres Humanos
Doenças do Complexo Imune/complicações
Masculino
Camundongos
Camundongos Knockout
Penfigoide Bolhoso/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1605
[Cu] Atualização por classe:160124
[Lr] Data última revisão:
160124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151201
[St] Status:MEDLINE



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