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[PMID]:26480010
[Au] Autor:Fantinato E; Binanti D
[Ti] Título:Pathology in Practice. Acute to subacute multifocal to coalescing necrosis of the myocardium.
[So] Source:J Am Vet Med Assoc;247(9):1023-5, 2015 Nov 01.
[Is] ISSN:1943-569X
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Camelus
Cardiopatias/veterinária
Necrose/veterinária
Doença do Músculo Branco/patologia
[Mh] Termos MeSH secundário: Animais
Evolução Fatal
Feminino
Cardiopatias/patologia
Necrose/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1608
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151020
[St] Status:MEDLINE
[do] DOI:10.2460/javma.247.9.1023


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[PMID]:25946682
[Au] Autor:Lee HK; Laug D; Zhu W; Patel JM; Ung K; Arenkiel BR; Fancy SP; Mohila C; Deneen B
[Ad] Endereço:Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas.
[Ti] Título:Apcdd1 stimulates oligodendrocyte differentiation after white matter injury.
[So] Source:Glia;63(10):1840-9, 2015 Oct.
[Is] ISSN:1098-1136
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Wnt signaling plays an essential role in developmental and regenerative myelination of the CNS, therefore it is critical to understand how the factors associated with the various regulatory layers of this complex pathway contribute to these processes. Recently, Apcdd1 was identified as a negative regulator of proximal Wnt signaling, however its role in oligodendrocyte (OL) differentiation and reymelination in the CNS remain undefined. Analysis of Apcdd1 expression revealed dynamic expression during OL development, where its expression is upregulated during differentiation. Functional studies using ex vivo and in vitro OL systems revealed that Apcdd1 promotes OL differentiation, suppresses Wnt signaling, and associates with ß-catenin. Application of these findings to white matter injury (WMI) models revealed that Apcdd1 similarly promotes OL differentiation after gliotoxic injury in vivo and acute hypoxia ex vivo. Examination of Apcdd1 expression in white matter lesions from neonatal WMI and adult multiple sclerosis revealed its expression in subsets of oligodendrocyte (OL) precursors. These studies describe, for the first time, the role of Apcdd1 in OLs after WMI and reveal that negative regulators of the proximal Wnt pathway can influence regenerative myelination, suggesting a new therapeutic strategy for modulating Wnt signaling and stimulating repair after WMI.
[Mh] Termos MeSH primário: Diferenciação Celular/fisiologia
Peptídeos e Proteínas de Sinalização Intracelular/metabolismo
Proteínas de Membrana/metabolismo
Oligodendroglia/fisiologia
Doença do Músculo Branco/patologia
[Mh] Termos MeSH secundário: Fatores Etários
Animais
Modelos Animais de Doenças
Regulação da Expressão Gênica no Desenvolvimento/efeitos dos fármacos
Regulação da Expressão Gênica no Desenvolvimento/fisiologia
Proteínas de Fluorescência Verde/genética
Proteínas de Fluorescência Verde/metabolismo
Seres Humanos
Hipóxia/complicações
Técnicas In Vitro
Peptídeos e Proteínas de Sinalização Intracelular/genética
Lisofosfatidilcolinas/toxicidade
Proteínas de Membrana/genética
Camundongos
Técnicas de Cultura de Órgãos
Medula Espinal/patologia
Células-Tronco/metabolismo
Células-Tronco/fisiologia
Doença do Músculo Branco/induzido quimicamente
Proteínas Wnt/metabolismo
Via de Sinalização Wnt/efeitos dos fármacos
Via de Sinalização Wnt/fisiologia
beta Catenina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (APCDD1 protein, human); 0 (Intracellular Signaling Peptides and Proteins); 0 (Lysophosphatidylcholines); 0 (Membrane Proteins); 0 (Wnt Proteins); 0 (beta Catenin); 147336-22-9 (Green Fluorescent Proteins)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:161202
[Lr] Data última revisão:
161202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150507
[St] Status:MEDLINE
[do] DOI:10.1002/glia.22848


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[PMID]:24470325
[Au] Autor:Lassmann H
[Ad] Endereço:Center for Brain Research, Medical University of Vienna, Austria.
[Ti] Título:Mechanisms of white matter damage in multiple sclerosis.
[So] Source:Glia;62(11):1816-30, 2014 Nov.
[Is] ISSN:1098-1136
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Glia cells are mediators as well as targets of the chronic inflammatory process in the central nervous system of multiple sclerosis (MS) patients. They are involved in the control of autoimmunity, in the propagation and termination of the inflammatory reaction, in the induction of demyelination and neurodegeneration, and in remyelination and scaring. Demyelination, as well as neuronal and GLIA cell damage are induced by different immunological mechanisms including components of the adaptive and innate immune system. Oxidative injury resulting in mitochondrial dysfunction is one important mechanism of tissue injury. It is in part driven by the inflammatory response and the production of oxygen radicals mainly in microglia and macrophages. With increasing age of the patients and disease progression, oxidative injury is further amplified by additional mechanisms including central nervous system damage related microglia activation, progressive mitochondrial damage, and age-dependent iron accumulation within the human central nervous system. The inflammatory mechanisms associated with lesion formation in MS are to a large extent reflected in experimental models of inflammatory demyelination, such as autoimmune encephalomyelitis. This is not the case for the amplification mechanisms of oxidative injury, which mainly operate in the progressive stage of the disease.
[Mh] Termos MeSH primário: Esclerose Múltipla/complicações
Proteínas da Mielina/metabolismo
Neuroglia/patologia
Doença do Músculo Branco
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Esclerose Múltipla/patologia
Neuroglia/metabolismo
Doença do Músculo Branco/etiologia
Doença do Músculo Branco/metabolismo
Doença do Músculo Branco/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Myelin Proteins)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:140912
[Lr] Data última revisão:
140912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140129
[St] Status:MEDLINE
[do] DOI:10.1002/glia.22597


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[PMID]:23715914
[Au] Autor:Verdelho A; Madureira S; Moleiro C; Ferro JM; O'Brien JT; Poggesi A; Pantoni L; Fazekas F; Scheltens P; Waldemar G; Wallin A; Erkinjuntti T; Inzitari D; LADIS Study
[Ad] Endereço:Department of Neurociences, University of Lisbon, Santa Maria Hospital, , Lisbon, Portugal.
[Ti] Título:Depressive symptoms predict cognitive decline and dementia in older people independently of cerebral white matter changes: the LADIS study.
[So] Source:J Neurol Neurosurg Psychiatry;84(11):1250-4, 2013 Nov.
[Is] ISSN:1468-330X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Depressive symptoms (DS) have been associated with increased risk of cognitive decline. Our aim was to evaluate the longitudinal influence of DS on cognition in independent older people, accounting for the severity of white matter changes (WMC). METHODS: The LADIS (Leukoaraiosis And DISability in the elderly) prospective study evaluated the impact of WMC on the transition of independent older subjects into disability. Subjects were evaluated annually over a 3 year period with a comprehensive clinical and neuropsychological evaluation. Previous episodes of depression and current DS were assessed during each interview. Severity of DS was assessed using the self-rated 15 item Geriatric Depression Scale. A neuropsychological battery and clinical criteria for cognitive impairments were applied in all clinical visits, and cognitive compound measures were made based on neuropsychological results. MRI was performed at baseline and at year 3. RESULTS: 639 subjects were included (74.1 ± 5 years old, 55% women, 9.6 ± 3.8 years of schooling). Dementia was diagnosed in 90 patients and cognitive impairment not dementia in 147 patients at the last clinical evaluation. DS were an independent predictor of cognitive impairment (dementia and not dementia) during follow-up, independent of the effect of the severity of WMC, medial temporal lobe atrophy, age, education or global cognitive function at baseline. CONCLUSIONS: DS are associated with an increase risk of cognitive decline, independent of the effect of WMC, probably due to an additive or synergistic effect. In this context, DS probably represent a subtle ongoing organic dysfunction.
[Mh] Termos MeSH primário: Doença de Alzheimer/diagnóstico
Disfunção Cognitiva/diagnóstico
Transtorno Depressivo/diagnóstico
Doença do Músculo Branco/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Doença de Alzheimer/epidemiologia
Doença de Alzheimer/psicologia
Animais
Encéfalo/patologia
Disfunção Cognitiva/epidemiologia
Disfunção Cognitiva/psicologia
Transtorno Depressivo/epidemiologia
Transtorno Depressivo/psicologia
Progressão da Doença
Feminino
Seres Humanos
Estudos Longitudinais
Imagem por Ressonância Magnética
Masculino
Testes Neuropsicológicos/estatística & dados numéricos
Psicometria
Medição de Risco
Doença do Músculo Branco/epidemiologia
Doença do Músculo Branco/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1311
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130530
[St] Status:MEDLINE
[do] DOI:10.1136/jnnp-2012-304191


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[PMID]:23499473
[Au] Autor:Drury PP; Gunn AJ; Bennet L; Ganeshalingham A; Finucane K; Buckley D; Beca J
[Ad] Endereço:Fetal Physiology and Neuroscience Group, Department of Physiology, University of Auckland, Auckland, New Zealand.
[Ti] Título:Deep hypothermic circulatory arrest during the arterial switch operation is associated with reduction in cerebral oxygen extraction but no increase in white matter injury.
[So] Source:J Thorac Cardiovasc Surg;146(6):1327-33, 2013 Dec.
[Is] ISSN:1097-685X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Deep hypothermic circulatory arrest may be associated with increased neural injury. We investigated whether short periods of deep hypothermic circulatory arrest are associated with altered neurophysiologic recovery or greater risk of injury. METHODS: Eighteen term infants with transposition of the great arteries undergoing the arterial switch operation were enrolled. Deep hypothermic circulatory arrest was used in 11, and bypass alone in 7. Near-infrared spectroscopy and amplitude-integrated electroencephalography were recorded with standard monitoring during and from 4 to 16 h after surgery. Fractional tissue oxygen extraction was determined from arterial oxygen saturation and venous weighted intracerebral oxygenation. Magnetic resonance imaging was performed before and 5 to 7 days after surgery. RESULTS: There were no significant differences between patients requiring deep hypothermic circulatory arrest (median, 5 min; range, 3-6 min) or cardiopulmonary bypass only at the beginning of surgery. At the end of surgery, amplitude-integrated electroencephalography minimum amplitude was significantly lower in the deep hypothermic circulatory arrest group (P < .05), and fractional tissue oxygen extraction tended to be lower (P = .068). After surgery, deep hypothermic circulatory arrest was associated with significantly higher tissue oxygenation index, lower fractional tissue oxygen extraction, and lower core temperature (P < .05). Magnetic resonance imaging-defined white matter injuries before and after surgery were similar between groups. CONCLUSIONS: In this prospective, observational study, brief deep hypothermic circulatory arrest during arterial switch was associated with reduced cerebral oxygen uptake during recovery, with transient electroencephalographic suppression but no increase in risk of white matter injury.
[Mh] Termos MeSH primário: Encéfalo/irrigação sanguínea
Procedimentos Cirúrgicos Cardíacos/efeitos adversos
Circulação Cerebrovascular
Parada Circulatória Induzida por Hipotermia Profunda/efeitos adversos
Consumo de Oxigênio
Transposição dos Grandes Vasos/cirurgia
Doença do Músculo Branco/etiologia
[Mh] Termos MeSH secundário: Análise de Variância
Animais
Regulação da Temperatura Corporal
Encéfalo/metabolismo
Encéfalo/patologia
Ponte Cardiopulmonar/efeitos adversos
Imagem de Difusão por Ressonância Magnética
Eletroencefalografia
Feminino
Seres Humanos
Recém-Nascido
Masculino
Monitorização Intraoperatória/métodos
Valor Preditivo dos Testes
Estudos Prospectivos
Fatores de Risco
Espectroscopia de Luz Próxima ao Infravermelho
Fatores de Tempo
Transposição dos Grandes Vasos/diagnóstico
Transposição dos Grandes Vasos/fisiopatologia
Resultado do Tratamento
Doença do Músculo Branco/diagnóstico
Doença do Músculo Branco/metabolismo
Doença do Músculo Branco/fisiopatologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; OBSERVATIONAL STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1401
[Cu] Atualização por classe:131115
[Lr] Data última revisão:
131115
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:130319
[St] Status:MEDLINE


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[PMID]:23409147
[Au] Autor:Ataollahi F; Mohri M; Seifi HA; Pingguan-Murphy B; Wan Abas WA; Osman NA
[Ad] Endereço:Department of Clinical Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran. forough_at@yahoo.com
[Ti] Título:Evaluation of copper concentration in subclinical cases of white muscle disease and its relationship with cardiac troponin I.
[So] Source:PLoS One;8(2):e56163, 2013.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present study aims to evaluate the serum level of copper (Cu) in lambs suffering from subclinical forms of white muscle disease (WMD) and its relationship with cardiac troponin I (cTn-I) as a novel biomarker of cardiovascular disorders. Ten milliliters of jugular blood were taken from 200 lambs less than one year old to measure serum concentrations of Cu, selenium (Se), and cTn-I. The subjects were divided into 2 groups, namely, the deficient group which included 36 lambs, and the control group which included 164 lambs according to the reference serum Se concentration (50 ng/mL). Serum Se levels in the deficient group were lower than 50 ng/mL. By contrast, the control group showed Se levels higher than 50 ng/mL. Differences among the serum Cu and cTn-I levels were determined in both groups. The mean ±SD and median of serum Cu and cTn-I levels in the deficient group were lower and higher than those in the control group, respectively. A significant positive correlation was observed between serum Cu and Se levels, and also serum Cu and Se levels showed a negative correlation with serum cTn-I concentrations. Stepwise linear regression analysis showed that serum Cu levels were correlated positively with serum Se levels (p<0.05). Receiver operating characteristic (ROC) curve analysis indicated that the area under curve (AUC) of Cu was significantly higher than that of cTn-I based on the reference diagonal line. It is important to keep in mind that the value of AUC for the ROC curve is between 0.5 and 1.00, in which the lowest accuracy is related to the reference diagonal line with AUC of 0.5. A cut-off was determined to indicate which Cu level can discriminate between affected and healthy lambs. The cut-off level, sensitivity, and specificity of Cu in this study were 144.5 ng/mL, 74%, and 61%, respectively.
[Mh] Termos MeSH primário: Cobre/sangue
Miocárdio/metabolismo
Troponina I/sangue
Doença do Músculo Branco/sangue
[Mh] Termos MeSH secundário: Animais
Área Sob a Curva
Prognóstico
Curva ROC
Selênio/sangue
Ovinos
Doença do Músculo Branco/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Troponin I); 789U1901C5 (Copper); H6241UJ22B (Selenium)
[Em] Mês de entrada:1307
[Cu] Atualização por classe:150219
[Lr] Data última revisão:
150219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130215
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0056163


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[PMID]:19345593
[Au] Autor:Gunes V; Ozcan K; Citil M; Onmaz AC; Erdogan HM
[Ad] Endereço:Department of Veterinary Internal Medicine, Faculty of Veterinary Medicine, University of Erciyes, Kayseri, Turkey. gunesvehbi@hotmail.com
[Ti] Título:Detection of myocardial degeneration with point-of-care cardiac troponin assays and histopathology in lambs with white muscle disease.
[So] Source:Vet J;184(3):376-8, 2010 Jun.
[Is] ISSN:1532-2971
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to evaluate the use of human cardiac troponin-I (cTn-I) and cardiac troponin-T (cTn-T) kits for the determination of myocardial degeneration in lambs suffering from white muscle disease (WMD). Cardiac troponin (cTn) analyses and necropsy were performed on 12 lambs with acute WMD. Only cTn analyses were tested in six healthy lambs. cTn-I and cTn-T tests were positive for all lambs with WMD, but negative in healthy lambs. Necropsy revealed that the cardiac and skeletal muscles of lambs with WMD had chalky white lesions, which appeared as necrosis and calcification in histopathology. The histopathological findings of the heart muscle and increased cTn in lambs with WMD suggested that marked myocardial degeneration may be detected by point-of-care cTn assays in lambs.
[Mh] Termos MeSH primário: Miocárdio/patologia
Doenças dos Ovinos/sangue
Troponina I/sangue
Troponina T/sangue
Doença do Músculo Branco/sangue
[Mh] Termos MeSH secundário: Animais
Biomarcadores/sangue
Feminino
Imuno-Histoquímica/veterinária
Masculino
Ovinos
Doenças dos Ovinos/diagnóstico
Doença do Músculo Branco/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Troponin I); 0 (Troponin T)
[Em] Mês de entrada:1006
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090407
[St] Status:MEDLINE
[do] DOI:10.1016/j.tvjl.2009.03.001


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[PMID]:19649021
[Au] Autor:Pourliotis K; Giadinis ND; Sofianidis G; Brellou GD; Psychas V; Roubies N; Karatzias H
[Ad] Endereço:Clinic of Farm Animals, School of Veterinary Medicine, Aristotle University of Thessaloniki, 11 St Voutyra Street, 546 27 Thessalonski, Greece.
[Ti] Título:Congenital nutritional myodegeneration (white muscle disease) in a red deer (Cervus elaphus) calf.
[So] Source:N Z Vet J;57(4):244-7, 2009 Aug.
[Is] ISSN:0048-0169
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CASE HISTORY: A 5-day-old red deer calf was submitted with tachypnoea and dyspnoea, and was reluctant to move. CLINICAL FINDINGS: Muscular damage was established via elevated creatinine phosphokinase (CPK) activities (5,000 U/L), while concentrations of Se in whole blood were low (24.8 nmol/L). The animal died despite treatment with penicillin and streptomycin and 0.1 mg/kg Se/vitamin E administered by S/C injection. DIAGNOSIS: Necropsy and histological examination of cardiac and skeletal muscle confirmed the presumptive diagnosis of congenital white muscle disease (WMD). Prophylactic administration of a Se/vitamin E commercial preparation (as above) to another calf born in the same herd one month later was associated with good health and apparently normal growth and development. CLINICAL RELEVANCE: Congenital WMD due to Se deficiency can be fatal in red deer calves. However, prophylactic administration of Se and vitamin E to neonatal calves may be beneficial for neonatal red deer calves.
[Mh] Termos MeSH primário: Cervos
Desnutrição/veterinária
Selênio/deficiência
Doença do Músculo Branco/congênito
Doença do Músculo Branco/patologia
[Mh] Termos MeSH secundário: Animais
Animais Lactentes
Evolução Fatal
Feminino
Grécia
Desnutrição/complicações
Desnutrição/tratamento farmacológico
Desnutrição/patologia
Selênio/administração & dosagem
Doença do Músculo Branco/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
H6241UJ22B (Selenium)
[Em] Mês de entrada:0911
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090804
[St] Status:MEDLINE
[do] DOI:10.1080/00480169.2009.36910


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[PMID]:18432100
[Au] Autor:Besselmann D; Schaub D; Wenker C; Völlm J; Robert N; Schelling C; Steinmetz H; Clauss M
[Ad] Endereço:Division of Zoo Animals and Exotic Pets, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, CH-8057 Zurich, Switzerland.
[Ti] Título:Juvenile mortality in captive lesser kudu (Tragelaphus imberbis) at Basle Zoo and its relation to nutrition and husbandry.
[So] Source:J Zoo Wildl Med;39(1):86-91, 2008 Mar.
[Is] ISSN:1042-7260
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Since 1956, when the Basle Zoo (Switzerland) initiated the breeding of lesser kudu (Tragelaphus imberbis), 43% of the lesser kudu juveniles died before reaching an age of 6 mo. In this study, the objective was to obtain the pathological findings, nutritional history, and family tree information in order to evaluate the influence of husbandry on juvenile mortality in these animals. The main cause of death was white muscle disease (WMD), diagnosed in 14 cases (26%) of the deceased juveniles. Although enclosure size had remained constant and animal accessibility to the public was constantly high, both herd size and juvenile mortality had increased from 1956-2004. The diet consumed by the whole group in 2004 had deficient levels of vitamin E and selenium. The increasing linear trend of the mortality rate since the 1960s was significant, and there was a significant correlation between herd size and overall juvenile mortality. In contrast, there was no correlation between herd size and the occurrence of juvenile mortality associated specifically with WMD. Other investigated factors (sex, inbreeding, and season) had no significant effect on overall mortality up to 6 mo of age or on mortality associated with WMD. These results characterize both a dietary and a husbandry problem, and are supported by a lack of similar juvenile mortality in another facility where the diet was supplemented with vitamin E, animal numbers were kept low, and the enclosure structure offered more retreat options for the animals.
[Mh] Termos MeSH primário: Criação de Animais Domésticos/métodos
Antílopes
Selênio/deficiência
Deficiência de Vitamina E/veterinária
Doença do Músculo Branco/mortalidade
[Mh] Termos MeSH secundário: Fatores Etários
Fenômenos Fisiológicos da Nutrição Animal/fisiologia
Animais
Animais Recém-Nascidos
Animais de Zoológico
Causas de Morte
Feminino
Seres Humanos
Masculino
Mortalidade
Estado Nutricional
Densidade Demográfica
Suíça/epidemiologia
Deficiência de Vitamina E/mortalidade
Doença do Músculo Branco/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
H6241UJ22B (Selenium)
[Em] Mês de entrada:0806
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080425
[St] Status:MEDLINE


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[PMID]:18185998
[Au] Autor:Deger Y; Mert H; Mert N; Yur F; Kozat S; Yörük IH; Sel T
[Ad] Endereço:Department of Biochemistry, Faculty of Veterinary Medicine, University of Yuzuncu Yil, 65080, Van, Turkey. ydeger65@hotmail.com
[Ti] Título:Serum selenium, vitamin E, and sialic acids concentrations in lambs with white muscle disease.
[So] Source:Biol Trace Elem Res;121(1):39-43, 2008 Jan.
[Is] ISSN:0163-4984
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to determine the serum concentrations of selenium, vitamin E, and total- and lipid-bound sialic acid (LBSA) in lambs with white muscle disease (WMD) before and after treatment with a commercial preparation containing selenite and vitamin E. Fifteen lambs with WMD and ten control animals were used as research materials. Blood samples were collected from both groups before- and 1 month after treatment for Se analysis by fluorimetry, whereas vitamin E and sialic acid were measured by HPLC and spectrophotometry, respectively. Compared to controls, in the diseased animals, there was a significant increase of serum total sialic acid (TSA) and LBSA, together with significant decreases of serum Se and vitamin E concentrations (p < 0.001). One month after treatment, a reversal of trend was observed with decreases of TSA and LBSA and increases of Se and vitamin E concentrations. The TSA and LBSA levels, however, remained significantly higher than those of the controls, p < 0.05 and 0.001, respectively. The Se and vitamin E concentrations of the treated animals were the same as those of controls. This is the first study on total and LBSA concentrations in lambs with WMD, showing that these markers can be used in the prognosis of the disease.
[Mh] Termos MeSH primário: Selênio/sangue
Doenças dos Ovinos/sangue
Ácidos Siálicos/sangue
Vitamina E/sangue
Doença do Músculo Branco/sangue
[Mh] Termos MeSH secundário: Animais
Lipídeos/sangue
Ovinos
Selenito de Sódio/uso terapêutico
Vitamina E/uso terapêutico
Doença do Músculo Branco/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lipids); 0 (Sialic Acids); 1406-18-4 (Vitamin E); H6241UJ22B (Selenium); HIW548RQ3W (Sodium Selenite)
[Em] Mês de entrada:0804
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080111
[St] Status:MEDLINE
[do] DOI:10.1007/s12011-007-0063-3



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