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[PMID]:29414690
[Au] Autor:Li X; Lin Z; Zhan X; Gao J; Sun L; Cao Y; Qiu H
[Ad] Endereço:Department of Endocrinology, First Affiliated Hospital Harbin Medical University, Harbin, Heilongjiang, PR China; Department of Pharmacology, The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical Un
[Ti] Título:RNA-seq analysis of the transcriptome of the liver of cynomolgus monkeys with type 2 diabetes.
[So] Source:Gene;651:118-125, 2018 Apr 20.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Genetic and environmental factors such as high-fat diet are involved in the development of type 2 diabetes mellitus (T2DM). Cynomolgus monkey shares similar genetic makeup, tissue structures, physiology and metabolic function to human. This study aimed to establish T2DM model in cynomolgus monkey and compare expression profiles of hepatic genes and their associated pathways in normal cynomolgus monkeys and those with T2DM. We employed RNA-seq technique and identified 1451 differentially expressed genes (DEGs) with a false discovery rate (FDR) of 0.1% between normal and T2DM animals. KEGG pathway analysis revealed that DEGs were associated with 12 KEGG pathways (P < 0.05). Two of these pathways were associated with metabolism and five were related to immunity. Unexpected, we found ECM-receptor interaction pathway. In conclusion, our data suggest that three major pathways may be implicated in the development of T2DM, including steroid biosynthesis, immune response and ECM. Further characterization of these pathways may provide new targets for the prevention and therapy of T2DM.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/veterinária
Fígado/metabolismo
Macaca fascicularis/genética
Doenças dos Macacos/genética
Transcriptoma
[Mh] Termos MeSH secundário: Animais
Diabetes Mellitus Experimental/genética
Diabetes Mellitus Tipo 2/genética
Diabetes Mellitus Tipo 2/imunologia
Diabetes Mellitus Tipo 2/metabolismo
Modelos Animais de Doenças
Ontologia Genética
Masculino
Redes e Vias Metabólicas
Doenças dos Macacos/imunologia
Doenças dos Macacos/metabolismo
Análise de Sequência de RNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE


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[PMID]:29239481
[Au] Autor:Torben W; Molehin AJ; Blair RV; Kenway C; Shiro F; Roslyn D; Chala B; Gutu D; Kebede MA; Ahmad G; Zhang W; Aye P; Mohan M; Lackner A; Siddiqui AA
[Ad] Endereço:Tulane National Primate Research Center, TNPRC, Comparative Pathology/Immunology, Tulane University Health Sciences Center, Covington, Louisiana.
[Ti] Título:The self-curing phenomenon of schistosome infection in rhesus macaques: insight from in vitro studies.
[So] Source:Ann N Y Acad Sci;1408(1):79-89, 2017 Nov.
[Is] ISSN:1749-6632
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A reduction in the burden of schistosomiasis is potentially achievable by integrating a schistosomiasis vaccine with current control measures. Here, we determine parasite-specific in vitro responses of B, T, and NK cells from naive uninfected rhesus macaques to Schistosoma mansoni (Sm) egg (SmEA) and worm antigen (SmWA) preparations isolated from infected baboons. Pronounced B cell responses to SmEA and NK cell responses to both SmEA and SmWA were observed. High levels of IL-2 and IL-21 responses against Sm antigens were observed in T and non-T cells of lymph nodes (LNs) and gut lamina propria-derived lymphocytes (LPLs). Data analysis showed multifunctionality of LN-derived CD4 , CD8 , and CD4 CD8 double positive T cells against either SmWA or SmWA+SmEA antigen preparations. Distinct SmEA-specific multifunctional responses were observed in gut LPLs, suggesting simultaneous responses against egg antigens. These data provide insight into the immune effectors involved in schistosome responses by rhesus macaques.
[Mh] Termos MeSH primário: Antígenos de Helmintos/imunologia
Doenças dos Macacos/imunologia
Schistosoma mansoni/imunologia
Esquistossomose mansoni/imunologia
Esquistossomose mansoni/veterinária
[Mh] Termos MeSH secundário: Animais
Linfócitos B/imunologia
Linfócitos T CD4-Positivos/imunologia
Linfócitos T CD8-Positivos/imunologia
Interleucina-2/imunologia
Interleucina-2/metabolismo
Interleucinas/imunologia
Interleucinas/metabolismo
Células Matadoras Naturais/imunologia
Linfonodos/imunologia
Macaca mulatta
Doenças dos Macacos/parasitologia
Papio
Remissão Espontânea
Schistosoma mansoni/fisiologia
Esquistossomose mansoni/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Helminth); 0 (Interleukin-2); 0 (Interleukins); 0 (interleukin-21)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1111/nyas.13565


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[PMID]:28968395
[Au] Autor:Chua TH; Manin BO; Daim S; Vythilingam I; Drakeley C
[Ad] Endereço:Department of Pathobiology and Medical Diagnostics, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia.
[Ti] Título:Phylogenetic analysis of simian Plasmodium spp. infecting Anopheles balabacensis Baisas in Sabah, Malaysia.
[So] Source:PLoS Negl Trop Dis;11(10):e0005991, 2017 Oct.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Anopheles balabacensis of the Leucospyrus group has been confirmed as the primary knowlesi malaria vector in Sabah, Malaysian Borneo for some time now. Presently, knowlesi malaria is the only zoonotic simian malaria in Malaysia with a high prevalence recorded in the states of Sabah and Sarawak. METHODOLOGY/PRINCIPAL FINDINGS: Anopheles spp. were sampled using human landing catch (HLC) method at Paradason village in Kudat district of Sabah. The collected Anopheles were identified morphologically and then subjected to total DNA extraction and polymerase chain reaction (PCR) to detect Plasmodium parasites in the mosquitoes. Identification of Plasmodium spp. was confirmed by sequencing the SSU rRNA gene with species specific primers. MEGA4 software was then used to analyse the SSU rRNA sequences and bulid the phylogenetic tree for inferring the relationship between simian malaria parasites in Sabah. PCR results showed that only 1.61% (23/1,425) of the screened An. balabacensis were infected with one or two of the five simian Plasmodium spp. found in Sabah, viz. Plasmodium coatneyi, P. inui, P. fieldi, P. cynomolgi and P. knowlesi. Sequence analysis of SSU rRNA of Plasmodium isolates showed high percentage of identity within the same Plasmodium sp. group. The phylogenetic tree based on the consensus sequences of P. knowlesi showed 99.7%-100.0% nucleotide identity among the isolates from An. balabacensis, human patients and a long-tailed macaque from the same locality. CONCLUSIONS/SIGNIFICANCE: This is the first study showing high molecular identity between the P. knowlesi isolates from An. balabacensis, human patients and a long-tailed macaque in Sabah. The other common simian Plasmodium spp. found in long-tailed macaques and also detected in An. balabacensis were P. coatneyi, P. inui, P. fieldi and P. cynomolgi. The high percentage identity of nucleotide sequences between the P. knowlesi isolates from the long-tailed macaque, An. balabacensis and human patients suggests a close genetic relationship between the parasites from these hosts.
[Mh] Termos MeSH primário: Anopheles/parasitologia
Doenças dos Macacos/parasitologia
Plasmodium knowlesi/classificação
Plasmodium knowlesi/genética
[Mh] Termos MeSH secundário: Animais
DNA de Protozoário/genética
Genes de RNAr
Macaca fascicularis/parasitologia
Malária/epidemiologia
Malária/parasitologia
Malária/transmissão
Malária/veterinária
Malásia/epidemiologia
Filogenia
Reação em Cadeia da Polimerase
RNA de Protozoário/genética
RNA Ribossômico/genética
Zoonoses/epidemiologia
Zoonoses/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Protozoan); 0 (RNA, Protozoan); 0 (RNA, Ribosomal)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005991


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[PMID]:28902879
[Au] Autor:Erkenswick GA; Watsa M; Pacheco MA; Escalante AA; Parker PG
[Ad] Endereço:Department of Biology and Whitney R. Harris World Ecology Center, University of Missouri-St. Louis, Saint Louis, Missouri, United States of America.
[Ti] Título:Chronic Plasmodium brasilianum infections in wild Peruvian tamarins.
[So] Source:PLoS One;12(9):e0184504, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There is an increased interest in potential zoonotic malarias. To date, Plasmodium malariae that infects humans remains indistinguishable from Plasmodium brasilianum, which is widespread among New World primates. Distributed throughout tropical Central and South America, the Callitrichidae are small arboreal primates in which detection of natural Plasmodium infection has been extremely rare. Most prior screening efforts have been limited to small samples, the use of low-probability detection methods, or both. Rarely have screening efforts implemented a longitudinal sampling design. Through an annual mark-recapture program of two sympatric callitrichids, the emperor (Saguinus imperator) and saddleback (Saguinus fuscicollis) tamarins, whole blood samples were screened for Plasmodium by microscopy and nested PCR of the cytochrome b gene across four consecutive years (2012-2015). Following the first field season, approximately 50% of the samples collected each subsequent year were from recaptured individuals. In particular, out of 245 samples from 129 individuals, 11 samples from 6 individuals were positive for Plasmodium, and all but one of these infections was found in S. imperator. Importantly, the cytochrome b sequences were 100% identical to former isolates of P. malariae from humans and P. brasilianum from Saimiri sp. Chronic infections were detected as evidenced by repeated infections (7) from two individuals across the 4-year study period. Furthermore, 4 of the 5 infected emperor tamarins were part of a single group spanning the entire study period. Overall, the low prevalence reported here is consistent with previous findings. This study identifies two new natural hosts for P. brasilianum and provides evidence in support of chronic infections in wildlife populations. Given that callitrichids are often found in mixed-species associations with other primates and can be resilient to human-disturbed environments, they could contribute to the maintenance of P. malariae populations if future work provides entomological and epidemiological evidence indicating human zoonotic infections.
[Mh] Termos MeSH primário: Malária/epidemiologia
Malária/veterinária
Doenças dos Macacos/epidemiologia
Saguinus/parasitologia
[Mh] Termos MeSH secundário: Animais
Animais Selvagens
Doença Crônica
DNA de Protozoário/genética
Feminino
Incidência
Malária/parasitologia
Masculino
Doenças dos Macacos/parasitologia
Peru/epidemiologia
Filogenia
Plasmodium/genética
Plasmodium/isolamento & purificação
Reação em Cadeia da Polimerase/veterinária
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Protozoan)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170914
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184504


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Pissinatti, Alcides
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[PMID]:28863180
[Au] Autor:Muniz CP; Zheng H; Jia H; Cavalcante LTF; Augusto AM; Fedullo LP; Pissinatti A; Soares MA; Switzer WM; Santos AF
[Ad] Endereço:Departamento de Genética, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
[Ti] Título:A non-invasive specimen collection method and a novel simian foamy virus (SFV) DNA quantification assay in New World primates reveal aspects of tissue tropism and improved SFV detection.
[So] Source:PLoS One;12(9):e0184251, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Simian foamy viruses (SFVs) co-evolved with a wide range of Old World and New World primates (OWPs and NWPs, respectively) and occasionally transmit to humans. Previous studies of OWPs showed that the predominant site of SFV replication is the oral mucosa. However, very little is known about SFV viral loads (VLs) in the oral mucosa or blood of NWPs. NWPs have smaller body sizes, limiting collection of sufficient whole blood volumes to molecularly detect and quantify SFV. Our study evaluated the use of noninvasively collected buccal swabs to detect NWP SFV compared with detection in blood using a new NWP SFV quantitative PCR (qPCR) assay. Buccal and blood samples were collected from 107 captive NWPs in Brazil comprising eleven distinct genera at the Primate Center of Rio de Janeiro (n = 58) and at Fundação Jardim Zoológico da Cidade do Rio Janeiro (n = 49). NWP SFV western blot (WB) testing was performed on a subset of animals for comparison with PCR results. The qPCR assay was validated using distinct SFV polymerase sequences from seven NWP genera (Callithrix, Sapajus, Saimiri, Ateles, Alouatta, Cacajao and Pithecia). Assay sensitivity was 20 copies/106 cells, detectable in 90% of replicates. SFV DNA VLs were higher in buccal swabs (5 log copies/106 cells) compared to peripheral blood mononuclear cells (PBMCs) (3 log copies/106 cells). The qPCR assay was also more sensitive than nested PCR for detection of NWP SFV infection and identified an additional 27 SFV-infected monkeys of which 18 (90%) were WB-positive and three that were WB-negative. We show the utility of using both blood and buccal swabs and our new qPCR assay for detection and quantification of diverse NWP SFV, which will assist a better understanding of the epidemiology of SFV in NWPs and any potential zoonotic infection risk for humans exposed to NWPs.
[Mh] Termos MeSH primário: Leucócitos Mononucleares/virologia
Primatas/virologia
Infecções por Retroviridae/diagnóstico
Vírus Espumoso dos Símios/genética
Manejo de Espécimes/métodos
[Mh] Termos MeSH secundário: Animais
Brasil
DNA Viral/genética
Seres Humanos
Doenças dos Macacos/diagnóstico
Doenças dos Macacos/virologia
Mucosa Bucal/virologia
Filogenia
Plasmídeos/metabolismo
Reação em Cadeia da Polimerase
Reação em Cadeia da Polimerase em Tempo Real
Infecções por Retroviridae/veterinária
Sensibilidade e Especificidade
Especificidade da Espécie
Tropismo Viral
Zoonoses/virologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184251


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Bonaldo, Myrna C
Castro, Marcia Gonçalves de
Texto completo SciELO Brasil
[PMID]:28591405
[Au] Autor:Bonaldo MC; Gómez MM; Dos Santos AA; Abreu FVS; Ferreira-de-Brito A; Miranda RM; Castro MG; Lourenço-de-Oliveira R
[Ad] Endereço:Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Biologia Molecular de Flavivírus, Rio de Janeiro, RJ, Brasil.
[Ti] Título:Genome analysis of yellow fever virus of the ongoing outbreak in Brazil reveals polymorphisms.
[So] Source:Mem Inst Oswaldo Cruz;112(6):447-451, 2017 Jun.
[Is] ISSN:1678-8060
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The current yellow fever outbreak in Brazil is the most severe one in the country in recent times. It has rapidly spread to areas where YF virus (YFV) activity has not been observed for more than 70 years and vaccine coverage is almost null. Here, we sequenced the whole YFV genome of two naturally infected howler-monkeys (Alouatta clamitans) obtained from the Municipality of Domingos Martins, state of Espírito Santo, Brazil. These two ongoing-outbreak genome sequences are identical. They clustered in the 1E sub-clade (South America genotype I) along with the Brazilian and Venezuelan strains recently characterised from infections in humans and non-human primates that have been described in the last 20 years. However, we detected eight unique amino acid changes in the viral proteins, including the structural capsid protein (one change), and the components of the viral replicase complex, the NS3 (two changes) and NS5 (five changes) proteins, that could impact the capacity of viral infection in vertebrate and/or invertebrate hosts and spreading of the ongoing outbreak.
[Mh] Termos MeSH primário: Alouatta/virologia
Genoma Viral/genética
Doenças dos Macacos/virologia
Polimorfismo Genético/genética
Febre Amarela/veterinária
Vírus da Febre Amarela/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Brasil/epidemiologia
Surtos de Doenças
Genótipo
Doenças dos Macacos/epidemiologia
Filogenia
Alinhamento de Sequência
Febre Amarela/epidemiologia
Febre Amarela/virologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE


  7 / 4389 MEDLINE  
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[PMID]:28569200
[Au] Autor:Yamazaki Y; Kawarai S; Morita H; Kikusui T; Iriki A
[Ad] Endereço:Advanced Research Centres, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. yumyam@a5.keio.jp.
[Ti] Título:Faecal transplantation for the treatment of Clostridium difficile infection in a marmoset.
[So] Source:BMC Vet Res;13(1):150, 2017 May 31.
[Is] ISSN:1746-6148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The common marmoset has been used as an experimental animal for various purposes. Because its average weight ranges from 250 to 500 g, weight loss quickly becomes critical for sick animals. Therefore, effective and non-stressful treatment for chronic diseases, including diarrhoea, is essential. CASE PRESENTATION: We report a case in which faecal microbiota transplantation (FMT) led to immediate recovery from chronic and recurrent diarrhoea caused by Clostridium difficile infection. A male common marmoset experienced chronic diarrhoea after antibiotic treatments. The animal experienced severe weight loss, and a faecal sample was confirmed to be C. difficile-positive but was negative for protozoa. Metronidazole was partially effective at the first administration but not after the recurrence of the clinical signs. Then, oral FMT was administered to the subject by feeding fresh faeces from healthy individuals mixed with the marmoset's usual food. We monitored the faeces by categorization into four groups: normal, loose, diarrhoea, and watery. After the first day of FMT treatment, the marmoset underwent a remarkable recovery from diarrhoea, and after the fourth day of treatment, a test for C. difficile was negative. The clinical signs did not recur. The marmoset recovered from sinusitis and bilateral dacryocystitis, which also did not recur, as a by-product of the improvement in its general health caused by the cessation of diarrhoea after the FMT. CONCLUSION: This is the first reported case of successful treatment of a marmoset using oral FMT. As seen in human patients, FMT was effective for the treatment of recurrent C. difficile infection in a captive marmoset.
[Mh] Termos MeSH primário: Callithrix/microbiologia
Infecções por Clostridium/veterinária
Clostridium difficile
Transplante de Microbiota Fecal/veterinária
Doenças dos Macacos/microbiologia
[Mh] Termos MeSH secundário: Animais
Infecções por Clostridium/terapia
Masculino
Doenças dos Macacos/terapia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.1186/s12917-017-1070-z


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[PMID]:28535867
[Au] Autor:Chinnadurai SK; Johnson JG; Langan JN
[Ad] Endereço:Chicago Zoological Society, Brookfield Zoo, Brookfield, Illinois;, Email: Sathya.chinnadurai@czs.org.
[Ti] Título:Comparison of 3 Methods for Preventing Perianesthetic Hypothermia in Callimicos ( ).
[So] Source:J Am Assoc Lab Anim Sci;56(3):318-321, 2017 05 01.
[Is] ISSN:1559-6109
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Perianesthetic hypothermia is one of the most common complications in veterinary anesthesia, especially in small patients with a large body surface area to mass ratio. During anesthesia, body heat can be lost through 4 mechanisms-radiation, convection, conduction, and evaporation-but anesthetists frequently address only one mechanism at a time. Here we sought to evaluate 3 methods of preventing perianesthetic hypothermia in callimicos (Callimico goeldii). In our experience, these small NHP routinely become hypothermic under even brief inhalant anesthesia. To address multiple routes of heat loss, animals received 1 of 3 treatments: 1) placement of a reflective blanket over the patient to limit radiative heat loss to the surrounding environment; 2) placement of a reflective blanket and use of a heated anesthetic circuit, which warmed the inspired air to 104 °F (40 °C), and 3) placement under the patient of a forced-air warming blanket set at 109.4 °F (43 °C). Sources of radiative heat loss were assessed by using infrared thermography. Each animal was anesthetized with isoflurane and maintained in sternal recumbency in a temperature-controlled room (65 °F; 18.3 °C); esophageal core body temperature was monitored every 5 min for a total of 30 min. The rate of heat loss did not differ between the use of a reflective blanket with or without a heated anesthetic circuit. Animals provided the forced-air warming blanket experienced a slight increase in average body temperature. According to these findings, an underbody warm-air blanket provided the best protection against hypothermia for callimicos in sternal recumbency.
[Mh] Termos MeSH primário: Temperatura Corporal
Callimico
Hipotermia/veterinária
Doenças dos Macacos/prevenção & controle
[Mh] Termos MeSH secundário: Anestésicos Inalatórios/efeitos adversos
Animais
Roupas de Cama, Mesa e Banho
Feminino
Hipotermia/prevenção & controle
Isoflurano/efeitos adversos
Masculino
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Inhalation); CYS9AKD70P (Isoflurane)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170525
[St] Status:MEDLINE


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[PMID]:28494342
[Au] Autor:Eberle R; Maxwell LK; Nicholson S; Black D; Jones-Engel L
[Ad] Endereço:Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, USA. Electronic address: r.eberle@okstate.edu.
[Ti] Título:Genome sequence variation among isolates of monkey B virus (Macacine alphaherpesvirus 1) from captive macaques.
[So] Source:Virology;508:26-35, 2017 Aug.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Complete genome sequences of 19 strains of monkey B virus (Macacine alphaherpesvirus 1; BV) isolated from several macaque species were determined. A low level of sequence variation was present among BV isolates from rhesus macaques. Most variation among BV strains isolated from rhesus macaques was located in regions of repetitive or quasi-repetitive sequence. Variation in coding sequences (polypeptides and miRNAs) was minor compared to regions of non-coding sequences. Non-coding sequences in the long and short repeat regions of the genome did however exhibit islands of conserved sequence. Oral and genital isolates from a single monkey were identical in sequence and varied only in the number of iterations of repeat units in several areas of repeats. Sequence variation between BV isolates from different macaque species (different BV genotypes) was much greater and was spread across the entire genome, confirming the existence of different genotypes of BV in different macaque species.
[Mh] Termos MeSH primário: Variação Genética
Genoma Viral
Herpes Simples/veterinária
Macaca mulatta/virologia
Doenças dos Macacos/virologia
Simplexvirus/genética
Simplexvirus/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Genótipo
Herpes Simples/virologia
Filogenia
Simplexvirus/classificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE


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[PMID]:28478775
[Au] Autor:Olarinmoye AO; Olugasa BO; Niphuis H; Herwijnen RV; Verschoor E; Boug A; Ishola OO; Buitendijk H; Fagrouch Z; Al-Hezaimi K
[Ad] Endereço:Engineer Abdullah Bugshan Research Chair for Growth Factors and Bone Regeneration (GFBR),King Saud University,Riyadh,Saudi Arabia.
[Ti] Título:Serological evidence of coronavirus infections in native hamadryas baboons (Papio hamadryas hamadryas) of the Kingdom of Saudi Arabia.
[So] Source:Epidemiol Infect;145(10):2030-2037, 2017 07.
[Is] ISSN:1469-4409
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The hamadryas baboon (Papio hamadryas hamadryas) is the only indigenous species of non-human primates (NHP) found in the Kingdom of Saudi Arabia (KSA). There are no peer-reviewed publications on viral infections of the baboons of KSA. Apart from camels, other animals are likely sources of the novel Middle East Respiratory Syndrome coronavirus (MERSCoV) for humans. We investigated evidence of highly pathogenic coronavirus infections including MERSCoV in a large group of commensal baboons accompanied by feral dogs, on the outskirts of Ta'if city, KSA, in February 2013. Fifty baboons (16 juveniles and 34 adults) were screened for serum antibodies to human coronaviruses (HCoV-043/-NL63/-229) and canine coronaviruses (CCoV-1-3) using direct Enzyme-linked Immunosorbent Assay (ELISA) technique and for MERSCoV antibodies using Serum Neutralization Test (SNT). Of the 50 sampled baboons, 22% (n = 11) were seropositive to HCoVs, 10% (n = 5) were seropositive to CCoVs, while none had detectable MERSCoV antibodies. These findings bear potentially significant implications for public health, canine health and baboon conservation efforts, necessitating follow-up investigations and preventive measures at locations where baboons frequent human habitations, or are regarded as tourist attractions, in KSA.
[Mh] Termos MeSH primário: Infecções por Coronavirus/veterinária
Coronavirus/isolamento & purificação
Doenças dos Macacos/epidemiologia
Papio hamadryas
[Mh] Termos MeSH secundário: Animais
Infecções por Coronavirus/epidemiologia
Infecções por Coronavirus/virologia
Feminino
Masculino
Coronavírus da Síndrome Respiratória do Oriente Médio/isolamento & purificação
Doenças dos Macacos/virologia
Prevalência
Arábia Saudita/epidemiologia
Estudos Soroepidemiológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.1017/S0950268817000905



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