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[PMID]:29269693
[Au] Autor:Yasuda K; Murase N; Ohtani R; Oka N; Nakamura M
[Ad] Endereço:Department of Neurology, National Hospital Organization Kyoto Medical Center.
[Ti] Título:[A case of chronic inflammatory demyelinating polyradiculoneuropathy, showing radicular pain due to tuberous hypertrophy of the spinal roots and plexuses after 20 years interval without relapsing sensorimotor symptoms].
[So] Source:Rinsho Shinkeigaku;58(1):21-24, 2018 Jan 26.
[Is] ISSN:1882-0654
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A 40-year-old man visited our department because of chest and back pain. He had a history of diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) 20 years ago. He received immunosuppressive therapy and had no relapses after that. On Admission, MRI showed tuberous hypertrophy of the spinal roots, intercostal nerves, and brachial and lumbar plexuses. The genetic analysis showed no mutations in any of Charcot-Marie-Tooth related genes. He was finally diagnosed with CIDP and administration of high dose intravenous methylprednisolone relieved his chest and back pain within a few days. We present a rare case of CIDP in which showed marked enlarged spinal roots in long clinical course and have a relapse with radicular pain without sensorimotor symptoms.
[Mh] Termos MeSH primário: Dor nas Costas/etiologia
Plexo Braquial/patologia
Dor no Peito/etiologia
Polirradiculoneuropatia Desmielinizante Inflamatória Crônica/complicações
Raízes Nervosas Espinhais/patologia
[Mh] Termos MeSH secundário: Adulto
Dor nas Costas/tratamento farmacológico
Plexo Braquial/diagnóstico por imagem
Dor no Peito/tratamento farmacológico
Seres Humanos
Hipertrofia
Infusões Intravenosas
Imagem por Ressonância Magnética
Masculino
Metilprednisolona/administração & dosagem
Polirradiculoneuropatia Desmielinizante Inflamatória Crônica/diagnóstico por imagem
Polirradiculoneuropatia Desmielinizante Inflamatória Crônica/tratamento farmacológico
Polirradiculoneuropatia Desmielinizante Inflamatória Crônica/patologia
Pulsoterapia
Raízes Nervosas Espinhais/diagnóstico por imagem
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
X4W7ZR7023 (Methylprednisolone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171223
[St] Status:MEDLINE
[do] DOI:10.5692/clinicalneurol.cn-001073


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[PMID]:29249634
[Au] Autor:Hirose M; Takano H; Hasegawa H; Tadokoro H; Hashimoto N; Takemura G; Kobayashi Y
[Ad] Endereço:Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
[Ti] Título:The effects of dipeptidyl peptidase-4 on cardiac fibrosis in pressure overload-induced heart failure.
[So] Source:J Pharmacol Sci;135(4):164-173, 2017 Dec.
[Is] ISSN:1347-8648
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Dipeptidyl peptidase-4 (DPP-4) inhibitors are hypoglycemic agents. DPP-4 inhibitor has cardioprotective effects after transverse aortic constriction (TAC), but role of DPP-4 on cardiac fibrosis after TAC is not well known. Our aim was to determine the effects of DPP-4 on cardiac fibrosis in murine TAC model. Wild-type mice and DPP-4 knockout mice were subjected to TAC. Wild-type mice were then treated with vehicle or DPP-4 inhibitor. DPP-4 activities in serum and heart tissue were significantly increased at 2 weeks after TAC, but they were significantly decreased by DPP-4 inhibitor treatment. The inhibition of DPP-4 did not affect left ventricular hypertrophy, but improved cardiac function and decreased myocardial and perivascular fibrosis after TAC. The inhibition of DPP-4 decreased the collagen type III/I ratio in myocardium. These results suggest that DPP-4 inhibition ameliorates the progression of heart failure after TAC by changing the quality and quantity of cardiac fibrosis.
[Mh] Termos MeSH primário: Cardiotônicos
Dipeptidil Peptidase 4/fisiologia
Inibidores da Dipeptidil Peptidase IV/farmacologia
Inibidores da Dipeptidil Peptidase IV/uso terapêutico
Insuficiência Cardíaca/tratamento farmacológico
Insuficiência Cardíaca/etiologia
Miocárdio/patologia
[Mh] Termos MeSH secundário: Animais
Aorta
Estenose da Valva Aórtica/complicações
Colágeno Tipo I/metabolismo
Colágeno Tipo III/metabolismo
Constrição Patológica
Dipeptidil Peptidase 4/metabolismo
Modelos Animais de Doenças
Fibrose
Insuficiência Cardíaca/patologia
Hipertensão/complicações
Hipertrofia
Masculino
Camundongos Endogâmicos C57BL
Miocárdio/metabolismo
Pressão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardiotonic Agents); 0 (Collagen Type I); 0 (Collagen Type III); 0 (Dipeptidyl-Peptidase IV Inhibitors); EC 3.4.14.5 (Dipeptidyl Peptidase 4)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


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[PMID]:29345464
[Au] Autor:Saande CJ; Jones SK; Rowling MJ; Schalinske KL
[Ad] Endereço:Interdepartmental Graduate Program in Nutritional Sciences and Department of Food Science and Human Nutrition, Iowa State University , Ames, Iowa 50011, United States.
[Ti] Título:Whole Egg Consumption Exerts a Nephroprotective Effect in an Acute Rodent Model of Type 1 Diabetes.
[So] Source:J Agric Food Chem;66(4):866-870, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nephropathy is a well-characterized complication of type 1 diabetes (T1D), resulting in proteinuria and urinary loss of micronutrients. We previously found that a whole egg-based diet maintained vitamin D balance in type 2 diabetic rats despite excessive urinary losses due to nephropathy. The goal of this study was to investigate the impact of whole egg consumption in T1D rats. Sprague-Dawley rats were randomly assigned to T1D or nondiabetic control groups and fed a casein or whole egg-based diet for 32 days. On day 26, two-thirds of the rats received a streptozotocin injection to induce T1D. Whole egg consumption attenuated polyuria, proteinuria, and renal hypertrophy in T1D rats. These data suggest that dietary intervention with whole egg may offer renal protection in T1D.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/complicações
Diabetes Mellitus Tipo 1/complicações
Nefropatias Diabéticas/prevenção & controle
Dieta
Ovos
[Mh] Termos MeSH secundário: Animais
Hipertrofia/prevenção & controle
Rim/patologia
Masculino
Poliúria/prevenção & controle
Proteinúria/prevenção & controle
Ratos
Ratos Sprague-Dawley
Vitamina D/sangue
Deficiência de Vitamina D/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
1406-16-2 (Vitamin D)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04774


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[PMID]:29262449
[Au] Autor:Ge CX; Tai MZ; Chen T; Li KL; Qin ZP
[Ad] Endereço:Special Department of Hemangiomas, Linyi Tumor Hospital, Linyi 276001, Shandong Province, China.
[Ti] Título:[Treatment analyses of 143 patients with maxillofacial and cervical venous malformations involved in isthmus faucium area].
[So] Source:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;52(12):909-914, 2017 Dec 07.
[Is] ISSN:1673-0860
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To analyze the clinical data and summarize therapeutic experiences of cervicofacial venous malformations involving isthmus faucium area. Clinical records from 143 patients with venous malformations involving isthmus faucium area treated at our hospital between January 2012 and January 2016 were reviewed. There were 70 males and 73 females. Age ranged from 1 to 52 years old, with a median age of 14.5 years. There were 19 cases with lesions involving in only 1 subanatomic area above and 124 cases with lesions involving in more than 1 subanatomic areas, including 63 cases with lesions involving in more than 2 areas. There were 50 patients presenting with additional maxillofacial and cervical lesions. Clinical symptoms included snoring ( =98), indistinct phonation ( =49), and tonsil hypertrophy more than degree â…¡ ( =19). Tracheotomy was performed in 3 patients prior to hospitalization, contigency tracheotomy during hospitalization in 10 patients, and oral trachea cannula in other patients. All therapeutic procedures, including single chemical ablation with ethanol injection ( =94), single lesion resection ( =9) and both of them ( =40), were performed under general anesthesia. Treatment remedies included mesh suture, macroglossia reduction and excision of maxillofacial and cervical lesions for patients presenting with extensive malformations extending to maxillofacial and cervical area. Tonsil resection were done in patients having tonsil venous malformations or tonsil hypertrophy more than degree II. Achauer's 4-grade criterion was applied to evaluate the treatment outcomes. SPSS 18.0 software was used to analyze the data. Trachea cannula were not extubated untill 24 to 48 hours after treatment. Emergency tracheotomy was done in 2 cases after extubations because of dyspnea, and successful extubations were obtained in other cases. There were no advents of pulmonary vascular spasm or pulmonary embolism. There was significant difference between before and after operation (snore: χ(2)=105.431, ambiguous pronunciation: χ(2)=59.698, tonsil hypertrophy more than degree â…¡: χ(2)=33.530, all <0.01). The patients were followed-up for 1-4 years, and there were 123 cases at grade â…£ (complete disappear of lesions in 62 cases without recurrence), 17 at grade â…¢ , 3 at grade â…¡, and no case at gradeâ… . Chemical ablation with ethanol injection for venous malformations involving isthmus faucium area is recommended, wheras combined remedies including injection, mesh suture, macroglossia reduction, and excision of cervicofacial lesions are suggested in treatment of extensive lesions extending to maxillofacial and cervical area. Tonsil resection should be done in patients having tonsil venous malformations or tonsil hypertrophy more than degree â…¡, which is safe and highly effective, with good reservation of function, in the treatment of maxillofacial and cervical venous malformations involving isthmus faucium area.
[Mh] Termos MeSH primário: Etanol/administração & dosagem
Orofaringe/irrigação sanguínea
Malformações Vasculares/terapia
Veias/anormalidades
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Terapia Combinada/métodos
Feminino
Seres Humanos
Hipertrofia/cirurgia
Lactente
Injeções
Masculino
Meia-Idade
Pescoço/irrigação sanguínea
Tonsila Palatina/irrigação sanguínea
Tonsila Palatina/patologia
Tonsila Palatina/cirurgia
Recidiva
Traqueotomia
Resultado do Tratamento
Malformações Vasculares/complicações
Malformações Vasculares/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
3K9958V90M (Ethanol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1673-0860.2017.12.007


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[PMID]:28468136
[Au] Autor:Ant A; Kemaloglu YK; Yilmaz M; Dilci A
[Ad] Endereço:*Department of Otorhinolaryngology, Faculty of Medicine, Gazi University †Department of Otorhinolaryngology, Ankara Oncology Education and Research Hospital, Ankara ‡Department of Otorhinolaryngology, Eskisehir Yunus Emre State Hospital, Eskisehir, Turkey.
[Ti] Título:Craniofacial Deviations in the Children With Nasal Obstruction.
[So] Source:J Craniofac Surg;28(3):625-628, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nasal obstruction mainly caused by adenoid hypertrophy in children affects the craniofacial growth and development process, and the craniofacial deviations and/or differences reported in the children are very similar to those in the adults with obstructive sleep apnea syndrome (OSAS). The authors aimed to look for relationships of the linear craniofacial dimensions in the children suffering from nasal obstruction with age, degree of clinical nasal obstruction score (CNOS), and relative size of the adenoid mass within the nasopharynx in their study.Fifty-five children suffering from nasal obstruction were retrospectively enrolled, and clinical data was used to calculate CNOS. On the lateral cephalometric radiographies, 9 linear variables were measured and adenoidal-nasopharyngeal ratio (ANR) was calculated.The data presented that, not CNOS, but ANR shown decrease by age, while many skeletal variables with exception of the nasopharyngeal and adenoidal postero-anterior dimensions were increased by age. Further, it was found that while CNOS were negatively correlated with the anterior cranial base length, anterior-superior facial height, and maxillary depth, ANR disclosed significant correlation only with the anteriorsuperior facial height. The authors' results support that nasal obstruction in the children was related not only to the adenoidal hypertrophy. Although relative size of the adenoidal mass in relation to the nasopharynx decreased by age, nasal obstruction was still present. Further, these results support that craniofacial deviations and/or differences in the children with nasal obstruction is similar to the adult OSAS patients. Smaller dimensions related to the naso-maxillary complex in the children with more severe nasal obstruction appear to be continuous by age. Hence, it could be said that narrow naso-maxillary complex could contribute to proceed nasal obstruction by age, which may contribute to OSAS in the adults.
[Mh] Termos MeSH primário: Tonsila Faríngea/patologia
Obstrução Nasal/etiologia
Crânio/patologia
[Mh] Termos MeSH secundário: Tonsila Faríngea/diagnóstico por imagem
Fatores Etários
Cefalometria
Criança
Pré-Escolar
Feminino
Seguimentos
Seres Humanos
Hipertrofia/complicações
Hipertrofia/diagnóstico por imagem
Masculino
Obstrução Nasal/diagnóstico por imagem
Obstrução Nasal/patologia
Radiografia
Estudos Retrospectivos
Crânio/diagnóstico por imagem
Crânio/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003409


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[PMID]:29277098
[Au] Autor:Pham TA; Berkowitz RG
[Ad] Endereço:1 Department of Otolaryngology, Royal Children's Hospital, Melbourne, VIC, Australia.
[Ti] Título:Targeted Tonsillar Biopsy for Unilateral Tonsillar Enlargement.
[So] Source:Ann Otol Rhinol Laryngol;127(2):113-117, 2018 Feb.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Unilateral tonsillar enlargement (UTE) is not an uncommon incidental finding. Lymphoma is the most common malignancy of the tonsils in children and presents with tonsillar enlargement. METHODS: This is a retrospective case series of all cases of histopathological analysis of tonsillectomy specimens at a single pediatric tertiary hospital between 1996 and 2015. Patients either had a preoperative indication (n = 53) for pathological testing or indications based on intraoperative findings (n = 88). Of the preoperative group, 17 patients had tonsillectomy for UTE alone. In 72% of cases, the side of perceived unilateral enlargement was confirmed at histopathological assessment. RESULTS: Zero cases of suspected malignancy were identified on testing. CONCLUSION: There is a very low prevalence of unsuspected and suspected malignancy in routine and targeted examination of tonsillar specimens. It is reasonable to test based on other clinical findings and risk factors such as immunosuppression.
[Mh] Termos MeSH primário: Biópsia/métodos
Tonsila Palatina/patologia
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Diagnóstico Diferencial
Feminino
Seres Humanos
Hipertrofia/patologia
Hipertrofia/cirurgia
Achados Incidentais
Lactente
Linfoma/patologia
Masculino
Estudos Retrospectivos
Neoplasias Tonsilares/patologia
Tonsilectomia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417749252


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[PMID]:27770257
[Au] Autor:Saha A; Rolfe R; Carroll S; Kelly DJ; Murphy P
[Ad] Endereço:Department of Zoology, School of Natural Sciences, Trinity College, Dublin, Ireland.
[Ti] Título:Chondrogenesis of embryonic limb bud cells in micromass culture progresses rapidly to hypertrophy and is modulated by hydrostatic pressure.
[So] Source:Cell Tissue Res;368(1):47-59, 2017 04.
[Is] ISSN:1432-0878
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Chondrogenesis in vivo is precisely controlled in time and space. The entire limb skeleton forms from cells at the core of the early limb bud that condense and undergo chondrogenic differentiation. Whether they form stable cartilage at the articular surface of the joint or transient cartilage that progresses to hypertrophy as endochondral bone, replacing the cartilage template of the skeletal rudiment, is spatially controlled over several days in the embryo. Here, we follow the differentiation of cells taken from the early limb bud (embryonic day 11.5), grown in high-density micromass culture and show that a self-organising pattern of evenly spaced cartilage nodules occurs spontaneously in growth medium. Although chondrogenesis is enhanced by addition of BMP6 to the medium, the spatial pattern of nodule formation is disrupted. We show rapid progression of the entire nodule to hypertrophy in culture and therefore loss of the local signals required to direct formation of stable cartilage. Dynamic hydrostatic pressure, which we have previously predicted to be a feature of the forming embryonic joint region, had a stabilising effect on chondrogenesis, reducing expression of hypertrophic marker genes. This demonstrates the use of micromass culture as a relatively simple assay to compare the effect of both biophysical and molecular signals on spatial and temporal control of chondrogenesis that could be used to examine the response of different types of progenitor cell, both adult- and embryo-derived.
[Mh] Termos MeSH primário: Técnicas de Cultura de Células/métodos
Condrogênese
Pressão Hidrostática
Botões de Extremidades/citologia
Botões de Extremidades/embriologia
[Mh] Termos MeSH secundário: Animais
Diferenciação Celular/genética
Células Cultivadas
Condrogênese/genética
Regulação da Expressão Gênica no Desenvolvimento
Hipertrofia
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1705
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE
[do] DOI:10.1007/s00441-016-2512-9


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[PMID]:29280868
[Au] Autor:Turini T; Weck Roxo AC; Serra-Guimarães F; Abreu ML; de Castro CC; Aboudib JH; Nahas FX
[Ad] Endereço:Rio de Janeiro and São Paulo, Brazil From the Division of Plastic and Reconstructive Surgery, Pedro Ernesto University Hospital, Rio de Janeiro State University; and the Division of Plastic Surgery, Federal University of São Paulo.
[Ti] Título:The Impact of Labiaplasty on Sexuality.
[So] Source:Plast Reconstr Surg;141(1):87-92, 2018 01.
[Is] ISSN:1529-4242
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Labiaplasty is one of the aesthetic procedures that has shown the greatest increase in the number of operations in recent years, although the absolute number of these procedures is still very low. Labia minora hypertrophy causes not only functional discomfort and sexual difficulties, but also embarrassment and aesthetic concern. The aim of this study was to assess the impact of labiaplasty on the patient's quality of life, self-esteem, and sexual function. METHODS: Twenty-four consecutive sexually active patients, who expressed the desire to undergo labiaplasty, were divided into two groups of 12 patients each: the intervention group that underwent labiaplasty immediately after responding the first questionnaires, and the control group that received no intervention during the study period. All patients were assessed for health-related quality of life, self-esteem, and sexual function using the Brazilian Portuguese versions of the Medical Outcomes Study 36-Item Short Form Health Survey, the Brazilian version of the Rosenberg Self-Esteem scale, and the Female Sexual Function Questionnaire, respectively. The questionnaires were administered at inclusion and at 3 and 6 months later in both groups. Comparisons within and between groups were performed. Statistical analysis was performed at a significance level of p < 0.05. RESULTS: No significant differences in Rosenberg Self-Esteem scale or Medical Outcomes Study 36-Item Short Form Health Survey score were found in either group during the study period. However, a significant improvement was found in the Female Sexual Function Questionnaire total score in the pain and enjoyment domains. CONCLUSION: Labiaplasty had a positive impact on sexual functioning of the study population.
[Mh] Termos MeSH primário: Técnicas Cosméticas/psicologia
Qualidade de Vida
Autoimagem
Disfunções Sexuais Fisiológicas/etiologia
Disfunções Sexuais Psicogênicas/etiologia
Sexualidade
Vulva/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seguimentos
Seres Humanos
Hipertrofia/complicações
Hipertrofia/psicologia
Hipertrofia/cirurgia
Meia-Idade
Estudos Prospectivos
Disfunções Sexuais Fisiológicas/diagnóstico
Disfunções Sexuais Fisiológicas/cirurgia
Disfunções Sexuais Psicogênicas/diagnóstico
Disfunções Sexuais Psicogênicas/cirurgia
Resultado do Tratamento
Vulva/patologia
Adulto Jovem
[Pt] Tipo de publicação:CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1097/PRS.0000000000003921


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[PMID]:29224765
[Au] Autor:Lai D; Qin G; Pu J; Liu L; Yang Y
[Ad] Endereço:Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China. Electronic address: lz_ld@126.com.
[Ti] Título:Pre- and post-operative application of acoustic rhinometry in children with otitis media with effusion and with or without adenoid hypertrophy-a retrospective analysis.
[So] Source:Int J Pediatr Otorhinolaryngol;103:51-54, 2017 Dec.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There is no standardized scheme for preoperative evaluation of adenoid hypertrophy or a consensus on surgical indications for adenoidectomy in children with otitis media with effusion (OME), especially for young children intolerant to nasal endoscopic assessment. The aim of this study was to evaluate the efficacy and reliability of acoustic rhinometry (AR) in evaluating benefits from adenoidectomy in children with OME. METHOD: Children with OME who were scheduled for surgical intervention were reviewed and AR tests performed preoperatively and postoperatively. The patients were divided into two groups based on the surgical strategy (Group I: tympanostomy tube placement alone; Group II: tympanostomy tube placement plus adenoidectomy). Correlation and regression analyses were performed to assess the relationship between findings of AR and nasal endoscopy. AR parameters including minimal nasal cross-sectional area (MCA), and nasopharyngeal volume (NPV), as well as scores of subjective symptoms were obtained to evaluate the utility of AR pre- and post-surgery. RESULTS: Sixty-five children aged 4-10 years who met the inclusion criteria were included. No significant differences in gender or age distribution were observed between Group I and Group II. MCA, as well as NPV significantly decreased in Group II when compared with Group I (p = 0.000). A significant inverse correlation was observed between NPV and choanal obstruction ratio in both groups I (r = -0.625, p < 0.001) and II (r = -0.570, p < 0.001). A significant difference between preoperative and postoperative NPV and subjective symptom scores was observed in group II after adenoidectomy (p = 0.000). CONCLUSION: AR parameters showed a good clinical correlation with findings of nasal endoscopy and thus may be useful for evaluating candidacy for surgical adenoidectomy among children with OME, especially in whom preoperative nasal endoscopic examination is not feasible. Additionally, AR can reveal the changes occurring within the nasopharyngeal passage before and after adenoidectomy.
[Mh] Termos MeSH primário: Adenoidectomia/métodos
Tonsila Faríngea/patologia
Ventilação da Orelha Média/métodos
Otite Média com Derrame/fisiopatologia
Rinometria Acústica/métodos
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Endoscopia
Feminino
Seres Humanos
Hipertrofia/cirurgia
Masculino
Cavidade Nasal/fisiopatologia
Otite Média com Derrame/cirurgia
Reprodutibilidade dos Testes
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


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[PMID]:28986442
[Au] Autor:Nuzzi LC; Firriolo JM; Pike CM; Cerrato FE; Webb ML; Faulkner HR; DiVasta AD; Labow BI
[Ad] Endereço:Adolescent Breast Clinic.
[Ti] Título:The Effect of Reduction Mammaplasty on Quality of Life in Adolescents With Macromastia.
[So] Source:Pediatrics;140(5), 2017 Nov.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To measure changes in health-related quality of life and breast-related symptoms after reduction mammaplasty in adolescents. METHODS: In this longitudinal cohort study, we administered the Short-Form 36v2 (SF-36), Rosenberg Self-Esteem Scale (RSES), Breast-Related Symptoms Questionnaire (BRSQ), and Eating Attitudes Test-26 to 102 adolescents with macromastia and 84 female controls, aged 12 to 21 years. Patients with macromastia completed surveys preoperatively and after reduction mammaplasty at 6 months and 1, 3, and 5 years. Controls completed baseline and follow-up surveys at the same intervals. RESULTS: Patients with macromastia demonstrated significant score improvements postoperatively from baseline on the RSES, BRSQ, and in 7 out of 8 SF-36 domains: physical functioning, role-physical, bodily pain, vitality, social functioning, role-emotional, mental health ( < .001, all). By the 6-month follow-up visit, postoperative subjects scored similarly to or more favorably than controls on the RSES, BRSQ, Eating Attitudes Test-26 , and SF-36; these benefits persisted for at least 5 years and were not significantly affected by BMI category or age. CONCLUSIONS: Reduction mammaplasty was significantly associated with improvements in health-related quality of life and breast-related symptoms of adolescent patients, with measureable improvements in physical and psychosocial well-being evident by 6 months postoperatively and still demonstrable after 5-years. These results largely do not vary by BMI category or age. Patients and providers should be aware of the potential positive impact that reduction mammaplasty can provide adolescents with symptomatic macromastia. Historic concerns regarding age and BMI category at the time of surgery should be reconsidered.
[Mh] Termos MeSH primário: Mama/anormalidades
Hipertrofia/psicologia
Hipertrofia/cirurgia
Mamoplastia/psicologia
Satisfação do Paciente
Qualidade de Vida/psicologia
Autoimagem
[Mh] Termos MeSH secundário: Adolescente
Mama/cirurgia
Criança
Estudos de Coortes
Feminino
Seguimentos
Seres Humanos
Estudos Longitudinais
Mamoplastia/tendências
Estudos Prospectivos
Inquéritos e Questionários
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171008
[St] Status:MEDLINE



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