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[PMID]:29373585
[Au] Autor:Espitia O; Chatelais M; Steenman M; Charrier C; Maurel B; Georges S; Houlgatte R; Verrecchia F; Ory B; Lamoureux F; Heymann D; Gouëffic Y; Quillard T
[Ad] Endereço:INSERM, UMR 1238, Nantes, France; Université de Nantes, Nantes Atlantique Universités, Laboratoire « Sarcome osseux et remodelage des tissus osseux calcifiés ¼, Faculté de Médecine, Nantes, France.
[Ti] Título:Implication of molecular vascular smooth muscle cell heterogeneity among arterial beds in arterial calcification.
[So] Source:PLoS One;13(1):e0191976, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vascular calcification is a strong and independent predictive factor for cardiovascular complications and mortality. Our previous work identified important discrepancies in plaque composition and calcification types between carotid and femoral arteries. The objective of this study is to further characterize and understand the heterogeneity in vascular calcification among vascular beds, and to identify molecular mechanisms underlying this process. We established ECLAGEN biocollection that encompasses human atherosclerotic lesions and healthy arteries from different locations (abdominal, thoracic aorta, carotid, femoral, and infrapopliteal arteries) for histological, cell isolation, and transcriptomic analysis. Our results show that lesion composition differs between these locations. Femoral arteries are the most calcified arteries overall. They develop denser calcifications (sheet-like, nodule), and are highly susceptible to osteoid metaplasia. These discrepancies may derive from intrinsic differences between SMCs originating from these locations, as microarray analysis showed specific transcriptomic profiles between primary SMCs isolated from each arterial bed. These molecular differences translated into functional disparities. SMC from femoral arteries showed the highest propensity to mineralize due to an increase in basal TGFß signaling. Our results suggest that biological heterogeneity of resident vascular cells between arterial beds, reflected by our transcriptomic analysis, is critical in understanding plaque biology and calcification, and may have strong implications in vascular therapeutic approaches.
[Mh] Termos MeSH primário: Artérias/patologia
Calcinose/patologia
Músculo Liso Vascular/patologia
[Mh] Termos MeSH secundário: Diferenciação Celular
Células Cultivadas
Seres Humanos
Placa Aterosclerótica/patologia
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191976


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[PMID]:28468787
[Au] Autor:Chandran S; Watkins J; Abdul-Aziz A; Shafat M; Calvert PA; Bowles KM; Flather MD; Rushworth SA; Ryding AD
[Ad] Endereço:Norfolk and Norwich University Hospital, Norwich, United Kingdom.
[Ti] Título:Inflammatory Differences in Plaque Erosion and Rupture in Patients With ST-Segment Elevation Myocardial Infarction.
[So] Source:J Am Heart Assoc;6(5), 2017 May 03.
[Is] ISSN:2047-9980
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Plaque erosion causes 30% of ST-segment elevation myocardial infarctions, but the underlying cause is unknown. Inflammatory infiltrates are less abundant in erosion compared with rupture in autopsy studies. We hypothesized that erosion and rupture are associated with significant differences in intracoronary cytokines in vivo. METHODS AND RESULTS: Forty ST-segment elevation myocardial infarction patients with <6 hours of chest pain were classified as ruptured fibrous cap (RFC) or intact fibrous cap (IFC) using optical coherence tomography. Plasma samples from the infarct-related artery and a peripheral artery were analyzed for expression of 102 cytokines using arrays; results were confirmed with ELISA. Thrombectomy samples were analyzed for differential mRNA expression using quantitative real-time polymerase chain reaction. Twenty-three lesions were classified as RFC (58%), 15 as IFC (38%), and 2 were undefined (4%). In addition, 12% (12 of 102) of cytokines were differentially expressed in both coronary and peripheral plasma. I-TAC was preferentially expressed in RFC (significance analysis of microarrays adjusted <0.001; ELISA IFC 10.2 versus RFC 10.8 log pg/mL; =0.042). IFC was associated with preferential expression of epidermal growth factor (significance analysis of microarrays adjusted <0.001; ELISA IFC 7.42 versus RFC 6.63 log pg/mL, =0.036) and thrombospondin 1 (significance analysis of microarrays adjusted =0.03; ELISA IFC 10.4 versus RFC 8.65 log ng/mL, =0.0041). Thrombectomy mRNA showed elevated I-TAC in RFC ( =0.0007) epidermal growth factor expression in IFC ( =0.0264) but no differences in expression of thrombospondin 1. CONCLUSIONS: These results demonstrate differential intracoronary cytokine expression in RFC and IFC. Elevated thrombospondin 1 and epidermal growth factor may play an etiological role in erosion.
[Mh] Termos MeSH primário: Doença da Artéria Coronariana/complicações
Citocinas/sangue
Mediadores da Inflamação/sangue
Placa Aterosclerótica
Infarto do Miocárdio com Supradesnível do Segmento ST/etiologia
[Mh] Termos MeSH secundário: Idoso
Biomarcadores/sangue
Angiografia Coronária
Doença da Artéria Coronariana/sangue
Doença da Artéria Coronariana/diagnóstico por imagem
Doença da Artéria Coronariana/terapia
Citocinas/genética
Ensaio de Imunoadsorção Enzimática
Fator de Crescimento Epidérmico/sangue
Feminino
Fibrose
Perfilação da Expressão Gênica/métodos
Seres Humanos
Masculino
Meia-Idade
Análise de Sequência com Séries de Oligonucleotídeos
Intervenção Coronária Percutânea
Estudos Prospectivos
Reação em Cadeia da Polimerase em Tempo Real
Fatores de Risco
Ruptura Espontânea
Infarto do Miocárdio com Supradesnível do Segmento ST/sangue
Infarto do Miocárdio com Supradesnível do Segmento ST/diagnóstico por imagem
Infarto do Miocárdio com Supradesnível do Segmento ST/terapia
Trombectomia
Trombospondina 1/sangue
Tomografia de Coerência Óptica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Cytokines); 0 (Inflammation Mediators); 0 (Thrombospondin 1); 0 (thrombospondin-1, human); 62229-50-9 (Epidermal Growth Factor)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE


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[PMID]:29406041
[Au] Autor:Mamudu HM; Jones A; Paul T; Subedi P; Wang L; Alamian A; Alamin AE; Blackwell G; Budoff M
[Ad] Endereço:Department of Health Services Management and Policy, College of Public Health, East Tennessee State University, Johnson City, Tennessee. Electronic address: mamudu@etsu.edu.
[Ti] Título:Geographic and Individual Correlates of Subclinical Atherosclerosis in an Asymptomatic Rural Appalachian Population.
[So] Source:Am J Med Sci;355(2):140-148, 2018 02.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study aimed to examine the association between subclinical atherosclerosis (ascertained as coronary artery calcium [CAC]) in asymptomatic individuals in the Central Appalachian region of the United States and individual- and geographic-level factors. MATERIALS AND METHODS: Data were obtained from participants in CAC screening between 2012 and 2016. CAC score was assessed as CAC = 0 (no plaque), 1 ≤ CAC ≤ 99 (mild plaque), 100 ≤ CAC ≤ 399 (moderate plaque) and CAC ≥ 400 (severe plaque). Additionally, data on demographics (age, sex and race), medical conditions, lifestyle factors and family history of coronary artery disease were obtained. Further, zip codes of place of residence for participants were used to generate geographic-level data. Descriptive statistics were used to estimate the prevalence of CAC, and multinomial logistic regression models were used to delineate significant factors. RESULTS: Of 1,512 participants, 57.6% had CAC > 0. The prevalence of mild, moderate and severe plaques was 31.6%, 16.3% and 9.7%, respectively. Demographics (age and sex), medical conditions, lifestyle factors and family history of coronary artery disease were associated with increased risk for subclinical atherosclerosis. Further, the proportion of minority residents significantly increased the risk for severe plaque (relative risk ratio = 1.06, P = 0.04) and the proportion of residents on government assistance significantly decreased the risk for mild plaque (relative risk ratio = 0.93, P = 0.03). CONCLUSIONS: The results imply that the proportion of minority residents in a geographic area is associated with increased relative risk for subclinical atherosclerosis, while the proportion of residents on government assistance decreased such risk. However, future geographic or neighborhood-level studies with a larger sample size are needed to delineate further the consistency of these results in the Central Appalachian population.
[Mh] Termos MeSH primário: Aterosclerose/epidemiologia
Placa Aterosclerótica/epidemiologia
População Rural
[Mh] Termos MeSH secundário: Região dos Apalaches/epidemiologia
Aterosclerose/fisiopatologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Placa Aterosclerótica/fisiopatologia
Prevalência
Fatores de Risco
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:27771154
[Au] Autor:Barbieri M; Marfella R; Esposito A; Rizzo MR; Angellotti E; Mauro C; Siniscalchi M; Chirico F; Caiazzo P; Furbatto F; Bellis A; D'Onofrio N; Vitiello M; Ferraraccio F; Paolisso G; Balestrieri ML
[Ad] Endereço:Department of Medical, Surgical, Neurological, Aging and Metabolic Sciences, Second University of Naples, Piazza Miraglia 2, 80138, Naples, Italy. Electronic address: michelangela.barbieri@unina2.it.
[Ti] Título:Incretin treatment and atherosclerotic plaque stability: Role of adiponectin/APPL1 signaling pathway.
[So] Source:J Diabetes Complications;31(2):295-303, 2017 Feb.
[Is] ISSN:1873-460X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AIMS: Glucagon like peptide 1 (GLP-1) analogues and dipeptidyl peptidase IV (DPP-4) inhibitors reduce atherosclerosis progression in type 2 diabetes mellitus (T2DM) patients and are associated with morphological and compositional characteristics of stable plaque phenotype. GLP-1 promotes the secretion of adiponectin which exerts anti-inflammatory effects through the adaptor protein PH domain and leucine zipper containing 1 (APPL1). The potential role of APPL1 expression in the evolution of atherosclerotic plaque in TDM2 patients has not previously evaluated. METHODS: The effect of incretin therapy in the regulation of adiponectin/APPL1 signaling was evaluated both on carotid plaques of asymptomatic diabetic (n=71) and non-diabetic patients (n=52), and through in vitro experiments on endothelial cell (EC). RESULTS: Atherosclerotic plaques of T2DM patients showed lower adiponectin and APPL1 levels compared with non-diabetic patients, along with higher oxidative stress, tumor necrosis factor-α (TNF-α), vimentin, and matrix metalloproteinase-9 (MMP-9) levels. Among T2DM subjects, current incretin-users presented higher APPL1 and adiponectin content compared with never incretin-users. Similarly, in vitro observations on endothelial cells co-treated with high-glucose (25mM) and GLP-1 (100nM) showed a greater APPL1 protein expression compared with high-glucose treatment alone. CONCLUSIONS: Our findings suggest a potential role of adiponectin/APPL1 signaling in mediating the effect of incretin in the prevention of atherosclerosis progression or plaque vulnerability in T2DM.
[Mh] Termos MeSH primário: Proteínas Adaptadoras de Transdução de Sinal/agonistas
Adiponectina/metabolismo
Diabetes Mellitus Tipo 2/tratamento farmacológico
Angiopatias Diabéticas/prevenção & controle
Incretinas/uso terapêutico
Placa Aterosclerótica/prevenção & controle
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Proteínas Adaptadoras de Transdução de Sinal/metabolismo
Idoso
Anti-Inflamatórios não Esteroides/farmacologia
Anti-Inflamatórios não Esteroides/uso terapêutico
Antioxidantes/farmacologia
Antioxidantes/uso terapêutico
Estenose das Carótidas/complicações
Estenose das Carótidas/epidemiologia
Estenose das Carótidas/prevenção & controle
Estenose das Carótidas/cirurgia
Células Cultivadas
Diabetes Mellitus Tipo 2/complicações
Diabetes Mellitus Tipo 2/metabolismo
Diabetes Mellitus Tipo 2/patologia
Angiopatias Diabéticas/epidemiologia
Angiopatias Diabéticas/patologia
Angiopatias Diabéticas/cirurgia
Endarterectomia das Carótidas
Endotélio Vascular/efeitos dos fármacos
Endotélio Vascular/imunologia
Endotélio Vascular/metabolismo
Endotélio Vascular/patologia
Feminino
Peptídeo 1 Semelhante ao Glucagon/metabolismo
Seres Humanos
Incretinas/farmacologia
Itália/epidemiologia
Masculino
Estresse Oxidativo/efeitos dos fármacos
Placa Aterosclerótica/complicações
Placa Aterosclerótica/epidemiologia
Placa Aterosclerótica/patologia
Fatores de Risco
Prevenção Secundária
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ADIPOQ protein, human); 0 (APPL1 protein, human); 0 (Adaptor Proteins, Signal Transducing); 0 (Adiponectin); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Antioxidants); 0 (Incretins); 89750-14-1 (Glucagon-Like Peptide 1)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29443790
[Au] Autor:Si D; Liu G; Tong Y; He Y
[Ad] Endereço:Department of Cardiology, China-Japan Union Hospital of Jilin University, Jilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular Disease, Jilin Provincial Cardiovascular Research Institute, Changchun, Jilin, China.
[Ti] Título:Rotational atherectomy ablation for an unexpandable stent under the guide of IVUS: A case report.
[So] Source:Medicine (Baltimore);97(7):e9978, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Inadequate stent expansion due to rigid calcified may result in restenosis lesions, but the available options are limited. PATIENT CONCERNS: We report a case via the trans-radial approach of the severely underexpanded freshly deployed stent due to heavily calcified plaques DIAGNOSES:: Coronary angiography revealed that there was no adequate expansion of the freshly deployed stent. INTERVENTIONS: Under the guide of intravascular ultrasound (IVUS), rotational atherectomy (RA) successfully ablated the stent layers and the protruding calcified plaque. Followed by balloon angioplasty, the ablated segment was scaffolded with another stent, well expanded and documented by IVUS. OUTCOMES: The patient was uneventful during the procedure and remained angina free at the point of one year of clinical follow-up. LESSONS: This case indicated that RA via the trans-radial approach could be a useful remedy in the situation of under-expansion of implanted stents, and the debulking should be performed under IVUS-guidance.
[Mh] Termos MeSH primário: Aterectomia Coronária/métodos
Placa Aterosclerótica/diagnóstico por imagem
Placa Aterosclerótica/cirurgia
Stents
Ultrassonografia de Intervenção
[Mh] Termos MeSH secundário: Idoso
Aterectomia Coronária/instrumentação
Angiografia Coronária
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009978


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[PMID]:29366786
[Au] Autor:Wei L; Zhao S; Wang G; Zhang S; Luo W; Qin Z; Bi X; Tan Y; Meng M; Qin J; Qin H; Tian D; Zhang A
[Ad] Endereço:Department of Pathology and Pathophysiology, Faculty of Basic Medical Sciences, School of Medicine, Guangxi University of Science and Technology, Liuzhou, Guangxi, China. Electronic address: lily206.student@sina.com.
[Ti] Título:SMAD7 methylation as a novel marker in atherosclerosis.
[So] Source:Biochem Biophys Res Commun;496(2):700-705, 2018 02 05.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Atherosclerosis is a complicated process comprising inflammation, accumulation of collagen matrix and aberrant DNA methylation. SMAD7 is known to play an important role in fibrosis and inflammation. In recent years, increasing research has concentrated on the connection between DNA methylation and atherosclerosis. The current study was designed to investigate methylation status of some specific gene with a focus on SMAD7 in atherosclerosis and elucidate their relationship. We found that SMAD7 expression was decreased and its promoter region was markedly methylated in atherosclerotic plaques when compared with normal artery walls. Using MALDI-TOF MS, increased DNA methylation levels of SMAD7 promoter at CpG unit 5.8.15.16 were found in peripheral blood of atherosclerosis patients relative to matched normal controls, respectively. Correlation analysis revealed that mean DNA methylation levels of SMAD7 promoter of CpG unit 5.8.15.16 were positively associated with homocysteine levels (r = 0.724, p < .001) and carotid plaque scores(r = 0.790, p < .001). SMAD7 promoter is hyper-methylated both in human atherosclerotic plaques and atherosclerosis patients, which is positively associated with homocysteine levels and carotid plaque scores. Thus, methylated SMAD7 may be a novel predicted marker and therapeutics target for atherosclerosis.
[Mh] Termos MeSH primário: Aterosclerose/diagnóstico
Aterosclerose/genética
Metilação de DNA
Proteína Smad7/genética
[Mh] Termos MeSH secundário: Idoso
Aterosclerose/patologia
Sequência de Bases
Ilhas de CpG
Feminino
Marcadores Genéticos/genética
Seres Humanos
Masculino
Placa Aterosclerótica/diagnóstico
Placa Aterosclerótica/genética
Placa Aterosclerótica/patologia
Prognóstico
Regiões Promotoras Genéticas
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Genetic Markers); 0 (SMAD7 protein, human); 0 (Smad7 Protein)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


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[PMID]:29374937
[Au] Autor:Liu ZJ; Shi B; Deng CC; Xu GX; Zhao RZ; Shen CY; Wang ZL; Liu HL
[Ad] Endereço:Department of Cardiology, First Affiliated Hospital, Zunyi Medical College, Zunyi 563003, China.
[Ti] Título:[Optical coherence tomographic analysis of in-stent neoatherosclerosis in lesions with restenosis after drug-eluting stent implantation].
[So] Source:Zhonghua Xin Xue Guan Bing Za Zhi;46(1):44-49, 2018 Jan 24.
[Is] ISSN:0253-3758
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To explore the imaging characteristics and related influencing factors of in-stent neoatherosclerosis (ISNA) in patients with restenosis after drug-eluting stent(DES) implantation with optical coherence tomography(OCT). A total of 25 cases of coronary heart disease patients(DES placement time ≥8 months) with coronary artery angiography showing DES in-stent restenosis (ISR) in Zunyi medical college affiliated hospital from July 2013 to December 2015 were included in this study and patient's data were retrospectively analyzed.In these patients with ISR, OCT images were acquired before percutaneous coronary intervention. Patients were divided into the ISNA group (12 patients and 12 lesions) and non-ISNA group(13 patients and 13 lesions) according to the result of OCT. ISNA on OCT was defined as neointima formation with the presence of lipids or calcification. (1) The incidence of chronic kidney disease and increased low-density lipoprotein cholesterol level in ISNA group were significant higher than that in non-ISNA group(all 0.05). The stent implantation time in ISNA group was longer than that in the non-ISNA group(53.0(14.0, 81.0) months vs. 15.0(8.5, 32.5) months, 0.01). In addition, clinical manifestation of acute coronary syndrome was present in 8 out of 12 patientsin ISNA group, and stable angina pectoris was found in 10 out of 13 casesin non-ISNA group( 0.01). (2) Quantitative analysis of OCT showed that the lumen area was less in ISNA group than in non-ISNA group((3.45±1.82)mm(2) vs. (4.17±1.68)mm(2), 0.01), and neointimal area(3.89(2.26, 5.52)mm(2) vs. 2.96(1.99, 4.22)mm(2), 0.01), neointimal load (53.15(40.18, 67.30)% vs. 41.54(32.08, 56.91)%, 0.01), neointimal thickness(0.98(0.63, 1.36)µm vs. 0.72(0.51, 1.03)µm, 0.01) were higher in ISNA group than in non-ISNA group.(3)Qualitative analysis of OCT showed that the prevalence of homogeneous intima was less in the ISNA group than in the non-ISNA group ((41.42±22.56)% vs.(72.06±18.68)%, 0.05), on the contrary, the heterogeneous intima was more common in the ISNA group ((58.57±22.56)% vs. (27.94±18.68)%, 0.05). There was no significant difference between two groups in the peri-stentmicrovessels (9/12 vs. 5/13, 0.05), and prevalence of intraintimalmicrovessels was higher in the ISNA group than in non-ISNA group (7/12 vs. 2/13, 0.05). In addition, thin cap fibrous plaque(7/12 vs. 0, 0.01), disrupted intima with visible cavity (7/12 vs. 1/13, 0.05),andintraluminal red thrombus(7/12 vs. 1/13, 0.05) were significantly higher in ISNA group than in non-ISNA group. Results of OCT show that ISNA occurs frequently in patients with ISR after DES implantation. The stent implantation time, incidence of chronic kidney disease and higher low-density lipoprotein cholesterol level are associated with the formation of ISNA in these patients.
[Mh] Termos MeSH primário: Reestenose Coronária/terapia
Stents Farmacológicos
Tomografia de Coerência Óptica
[Mh] Termos MeSH secundário: Constrição Patológica
Angiografia Coronária
Vasos Coronários
Doenças das Valvas Cardíacas
Seres Humanos
Neointima
Intervenção Coronária Percutânea
Placa Aterosclerótica
Estudos Retrospectivos
Stents
Fatores de Tempo
Túnica Íntima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180129
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0253-3758.2018.01.008


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[PMID]:29233836
[Au] Autor:Kolossváry M; Karády J; Szilveszter B; Kitslaar P; Hoffmann U; Merkely B; Maurovich-Horvat P
[Ad] Endereço:From the MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary (M.K., J.K., B.S., B.M., P.M.-H.); Department of Radiology, Leiden University Medical Center, The Netherlands (P.K.); Medis Medical Imaging Systems B.V., Leiden, The Netherlands
[Ti] Título:Radiomic Features Are Superior to Conventional Quantitative Computed Tomographic Metrics to Identify Coronary Plaques With Napkin-Ring Sign.
[So] Source:Circ Cardiovasc Imaging;10(12), 2017 Dec.
[Is] ISSN:1942-0080
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Napkin-ring sign (NRS) is an independent prognostic imaging marker of major adverse cardiac events. However, identification of NRS is challenging because of its qualitative nature. Radiomics is the process of extracting thousands of quantitative parameters from medical images to create big-data data sets that can identify distinct patterns in radiological images. Therefore, we sought to determine whether radiomic analysis improves the identification of NRS plaques. METHODS AND RESULTS: From 2674 patients referred to coronary computed tomographic angiography caused by stable chest pain, expert readers identified 30 patients with NRS plaques and matched these with 30 non-NRS plaques with similar degree of calcification, luminal obstruction, localization, and imaging parameters. All plaques were segmented manually, and image data information was analyzed using Radiomics Image Analysis package for the presence of 8 conventional and 4440 radiomic parameters. We used the permutation test of symmetry to assess differences between NRS and non-NRS plaques, whereas we calculated receiver-operating characteristics' area under the curve values to evaluate diagnostic accuracy. Bonferroni-corrected <0.0012 was considered significant. None of the conventional quantitative parameters but 20.6% (916/4440) of radiomic features were significantly different between NRS and non-NRS plaques. Almost half of these (418/916) reached an area under the curve value >0.80. Short- and long-run low gray-level emphasis and surface ratio of high attenuation voxels to total surface had the highest area under the curve values (0.918; 0.894 and 0.890, respectively). CONCLUSIONS: A large number of radiomic features are different between NRS and non-NRS plaques and exhibit excellent discriminatory value.
[Mh] Termos MeSH primário: Angiografia por Tomografia Computadorizada
Doença da Artéria Coronariana/diagnóstico por imagem
Mineração de Dados/métodos
Técnicas de Apoio para a Decisão
Placa Aterosclerótica/diagnóstico por imagem
Interpretação de Imagem Radiográfica Assistida por Computador/métodos
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Modelagem Computacional Específica para o Paciente
Medicina de Precisão
Valor Preditivo dos Testes
Prognóstico
Estudos Retrospectivos
Software
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE


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[PMID]:29279527
[Au] Autor:Ishikawa Y; Itoh T; Satoh M; Fusazaki T; Sugawara S; Nakajima S; Nakamura M; Morino Y
[Ad] Endereço:Division of Cardiology, Department of Internal Medicine, Iwate Medical University.
[Ti] Título:Impact of Water- and Lipid-Soluble Statins on Nonculprit Lesions in Patients with Acute Coronary Syndrome.
[So] Source:Int Heart J;59(1):27-34, 2018 Jan 27.
[Is] ISSN:1349-3299
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Statins can be differentiated into two types, based on their solubility, which have potentially differing effects on the coronary artery wall. However, suspected differences in statins' effects on plaque composition have not been systemically investigated.Sixty-seven patients with acute coronary syndrome (ACS) were randomly assigned to either atorvastatin (10 mg/day) or rosuvastatin (2.5 mg/day). Intravascular ultrasound (IVUS) and integrated backscatter (IB)-IVUS, an established tool to quantify each plaque's components, were performed immediately after emergent percutaneous coronary intervention (PCI). Follow-up IVUS was performed between 6 and 12 months after PCI. Serial changes in serum lipid profiles and plaque composition volumes were compared between the two groups.Thirty-five patients were eligible for serial IB-IVUS analyses. The mean low-density lipoprotein-cholesterol level significantly decreased in the atorvastatin and rosuvastatin groups (P < 0.001); plaque volumes were also significantly reduced from 82.0 ± 46.2 to 74.9 ± 41.3 mm (P = 0.01) and from 74.7 ± 35.3 to 67.7 ± 27.0 mm (P = 0.02), respectively. IB-IVUS revealed a significant reduction in fibrous volume from 33.8 ± 20.0 to 27.5 ± 14.9 mm (P < 0.01) and from 29.6 ± 13.6 to 24.8 ± 7.6 mm (P < 0.05), respectively; however, significant changes were not noted in the volume of the lipid pool for the atorvastatin group and the rosuvastatin group, respectively.Water- and lipid-soluble statins may be similarly effective in reducing coronary plaques in patients with ACS as judged qualitatively and quantitatively. Further study is needed to determine whether differences between water- and lipid-soluble statins affect plaque components.
[Mh] Termos MeSH primário: Síndrome Coronariana Aguda/tratamento farmacológico
Atorvastatina Cálcica/administração & dosagem
Vasos Coronários/diagnóstico por imagem
Lipídeos/sangue
Placa Aterosclerótica/tratamento farmacológico
Rosuvastatina Cálcica/administração & dosagem
[Mh] Termos MeSH secundário: Síndrome Coronariana Aguda/sangue
Síndrome Coronariana Aguda/diagnóstico por imagem
Idoso
Biomarcadores/sangue
Relação Dose-Resposta a Droga
Feminino
Seguimentos
Seres Humanos
Inibidores de Hidroximetilglutaril-CoA Redutases/administração & dosagem
Masculino
Meia-Idade
Placa Aterosclerótica/sangue
Placa Aterosclerótica/diagnóstico por imagem
Estudos Prospectivos
Índice de Gravidade de Doença
Fatores de Tempo
Resultado do Tratamento
Ultrassonografia de Intervenção
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Biomarkers); 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors); 0 (Lipids); 48A5M73Z4Q (Atorvastatin Calcium); 83MVU38M7Q (Rosuvastatin Calcium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1536/ihj.16-587


  10 / 5895 MEDLINE  
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[PMID]:29368910
[Au] Autor:Sinyov VV; Chicheva MM; Barinova VA; Ryzhkova AI; Zilinyi RI; Karagodin VP; Postnov AY; Sobenin IA; Orekhov AN; Sazonova MA
[Ti] Título:[The heteroplasmy level of some mutations in gene MT-CYB among women with asymptomatic atherosclerosis].
[So] Source:Genetika;52(8):951-7, 2016 Aug.
[Is] ISSN:0016-6758
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Atherosclerosis is a polygenic socially significant disease whose risk factors include coronary heart disease, diabetes, hypertension, and myocardial infarction. According to the literature, mutations m.14846G>A (G34S), m.15762G>A (G339Q), m.15084G>A (W113Ter), and m.15059G>A (G190Ter) of cytochrome B gene (MT-CYB) are associated with mitochondrial myopathies, myoglobinuria, and exercise intolerance. Preliminary studies carried out by the authors made it possible to discover an association of certain mitochondrial genome mutations with atherosclerotic lesions of aortic intima in people who died as a result of an accident or sudden death. The most interesting seemed to be the data on the association of mutations m.14846G>A and m.15059G>A of the cytochrome B gene with lipofibrous aortic plaques, because these mutations affect the mitochondrial respiratory chain enzyme. Defects in the given chain may be the reason for the launch of pathogenic mechanisms in the human body. Owing to the fact that mutations in the mitochondrial genome are inherited by the maternal type, it was decided to analyze cytochrome B gene mutations in a sample of female volunteers from Moscow oblast. According to the findings, mutations m.14846G>A and m.15059G>A are highly significantly associated with atherosclerotic lesions of the carotid arteries: m.14846G>A is antiatherogenic and m.15059G>A is proatherogenic.
[Mh] Termos MeSH primário: Aterosclerose/genética
Doenças das Artérias Carótidas/genética
Citocromos b/genética
Mutação
Placa Aterosclerótica/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Aterosclerose/enzimologia
Doenças das Artérias Carótidas/enzimologia
Feminino
Seres Humanos
Meia-Idade
Placa Aterosclerótica/enzimologia
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
9035-37-4 (Cytochromes b)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE



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