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[PMID]:29208252
[Au] Autor:Khalaf M; Brock AS; Castell D
[Ad] Endereço:Division of Gastroenterology & Hepatology, Medical University of South Carolina, Charleston, South Carolina. Electronic address: khalaf@musc.edu.
[Ti] Título:Sporadic Fundic Gland Polyps and Gastric Acid Suppression Level.
[So] Source:Am J Med Sci;354(6):561-564, 2017 12.
[Is] ISSN:1538-2990
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Fundic gland polyps (FGPs) are a common endoscopic finding and are known to be associated with proton pump inhibitors (PPIs) use. It is not known if their prevalence is affected by gastric acidity levels. This study aimed to assess whether there is a correlation between FGPs and gastric acidity levels as identified on 24-hour ambulatory impedance-pH studies in patients on PPI therapy. METHODS: We performed a review of 402 consecutive patients who take at least once daily PPI and underwent esophagogastroduodenoscopy with combined impedance-pH studies in the same setting (time and place) between January 2010 and December 2014. Patients were classified into 2 groups based on the presence or absence of biopsy-confirmed FGPs during endoscopy. RESULTS: Of the 402 patients, 30 (7%) had FGPs. One of these polyps was found with low-grade dysplasia. There was no significant difference of the distributions of the [H ] in the FGPs versus the nonpolyp groups (P = 0.741). There was no significant difference between the 2 groups regarding PPI dose frequency regimens (once and twice) (P = 0.074). However, we found weak ordinal association with PPI duration (P = 0.01) (Spearman = 0.1). CONCLUSIONS: FGPs are common endoscopic lesions. Incidence of dysplasia in FGPs is not only rare, but also of unknown clinical significance. Although they seem to be associated with PPIs, the mechanism remains unclear, as we found no correlation between the presence of FGPs and gastric acid control or PPI dose. Future studies would be useful to elucidate an alternate mechanism.
[Mh] Termos MeSH primário: Ácido Gástrico/secreção
Pólipos/fisiopatologia
Neoplasias Gástricas/fisiopatologia
[Mh] Termos MeSH secundário: Idoso
Endoscopia do Sistema Digestório
Feminino
Determinação da Acidez Gástrica
Seres Humanos
Concentração de Íons de Hidrogênio
Masculino
Meia-Idade
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


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[PMID]:28450390
[Au] Autor:East JE; Atkin WS; Bateman AC; Clark SK; Dolwani S; Ket SN; Leedham SJ; Phull PS; Rutter MD; Shepherd NA; Tomlinson I; Rees CJ
[Ad] Endereço:Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
[Ti] Título:British Society of Gastroenterology position statement on serrated polyps in the colon and rectum.
[So] Source:Gut;66(7):1181-1196, 2017 07.
[Is] ISSN:1468-3288
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Serrated polyps have been recognised in the last decade as important premalignant lesions accounting for between 15% and 30% of colorectal cancers. There is therefore a clinical need for guidance on how to manage these lesions; however, the evidence base is limited. A working group was commission by the British Society of Gastroenterology (BSG) Endoscopy section to review the available evidence and develop a position statement to provide clinical guidance until the evidence becomes available to support a formal guideline. The scope of the position statement was wide-ranging and included: evidence that serrated lesions have premalignant potential; detection and resection of serrated lesions; surveillance strategies after detection of serrated lesions; special situations-serrated polyposis syndrome (including surgery) and serrated lesions in colitis; education, audit and benchmarks and research questions. Statements on these issues were proposed where the evidence was deemed sufficient, and re-evaluated modified via a Delphi process until >80% agreement was reached. The Grading of Recommendations, Assessment, Development and Evaluations (GRADE) tool was used to assess the strength of evidence and strength of recommendation for finalised statements. : we suggest that until further evidence on the efficacy or otherwise of surveillance are published, patients with sessile serrated lesions (SSLs) that appear associated with a higher risk of future neoplasia or colorectal cancer (SSLs ≥10 mm or serrated lesions harbouring dysplasia including traditional serrated adenomas) should be offered a one-off colonoscopic surveillance examination at 3 years ( ).
[Mh] Termos MeSH primário: Pólipos do Colo/diagnóstico
Pólipos do Colo/cirurgia
Pólipos/diagnóstico
Pólipos/cirurgia
Doenças Retais/diagnóstico
Doenças Retais/cirurgia
[Mh] Termos MeSH secundário: Adenoma/diagnóstico
Adenoma/genética
Adenoma/cirurgia
Polipose Adenomatosa do Colo/diagnóstico
Benchmarking
Biomarcadores/análise
Transformação Celular Neoplásica
Colite/complicações
Pólipos do Colo/genética
Colonoscopia
Ilhas de CpG/genética
DNA/isolamento & purificação
Metilação de DNA
Fezes/química
Seres Humanos
Parassimpatolíticos/uso terapêutico
Pólipos/genética
Lesões Pré-Cancerosas/diagnóstico
Lesões Pré-Cancerosas/cirurgia
Doenças Retais/genética
Terminologia como Assunto
Conduta Expectante
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRACTICE GUIDELINE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Parasympatholytics); 9007-49-2 (DNA)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1136/gutjnl-2017-314005


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[PMID]:29188462
[Au] Autor:Kim JH; Chang YS; Lee DW; Kim CG; Kim JW
[Ad] Endereço:Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, #156 Youngdeungpo-dong 4ga, Youngdeungpo-gu, Seoul, 150-034, South Korea. kimoph@gmail.com.
[Ti] Título:Quantification of retinal changes after resolution of submacular hemorrhage secondary to polypoidal choroidal vasculopathy.
[So] Source:Jpn J Ophthalmol;62(1):54-62, 2018 Jan.
[Is] ISSN:1613-2246
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate changes in the thickness of retinal layers after resolution of submacular hemorrhage secondary to polypoidal choroidal vasculopathy (PCV). STUDY DESIGN: Retrospective, observational study. METHODS: This study included 21 patients (21 eyes) who had been diagnosed with submacular hemorrhage secondary to PCV and treated using anti-vascular endothelial growth factor monotherapy. After the hemorrhage had resolved, the thicknesses of the retinal layers were measured on horizontal- and vertical-crosshair optical coherence tomography scan images. The thickness of each layer in the region affected by the hemorrhage was compared with the thickness of the layer in the corresponding region in the fellow eye, as well as between an unaffected region in the eye with the hemorrhage and the corresponding region in the fellow eye. RESULTS: Optical coherence tomography (OCT) was performed 5.5±2.8 months after diagnosis. In the horizontal OCT images, the outer plexiform layer (OPL) and outer nuclear layer (ONL) + photoreceptor layer (PRL) were significantly thinner in the affected region than in the corresponding region (P = 0.019 and P <0.001, respectively). In the vertical OCT image, the ONL+PRL was significantly thinner in the affected region than in the corresponding region (P <0.001). The thickness of the retinal layer in the unaffected region did not differ from that in the corresponding region of the fellow eye. CONCLUSIONS: The significant thinning of the outer retinal layers in the regions affected by submacular hemorrhage suggests that the hemorrhage induces marked damage in the outer retinal layers, explaining the poor visual prognosis of submacular hemorrhage.
[Mh] Termos MeSH primário: Neovascularização de Coroide/fisiopatologia
Pólipos/fisiopatologia
Hemorragia Retiniana/fisiopatologia
Neurônios Retinianos/patologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Inibidores da Angiogênese/uso terapêutico
Neovascularização de Coroide/complicações
Neovascularização de Coroide/tratamento farmacológico
Corantes/administração & dosagem
Feminino
Angiofluoresceinografia
Seres Humanos
Verde de Indocianina/administração & dosagem
Injeções Intravítreas
Masculino
Meia-Idade
Pólipos/complicações
Pólipos/tratamento farmacológico
Ranibizumab/uso terapêutico
Receptores de Fatores de Crescimento do Endotélio Vascular/uso terapêutico
Proteínas Recombinantes de Fusão/uso terapêutico
Hemorragia Retiniana/tratamento farmacológico
Hemorragia Retiniana/etiologia
Estudos Retrospectivos
Tomografia de Coerência Óptica
Fator A de Crescimento do Endotélio Vascular/antagonistas & inibidores
Acuidade Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (Coloring Agents); 0 (Recombinant Fusion Proteins); 0 (VEGFA protein, human); 0 (Vascular Endothelial Growth Factor A); 15C2VL427D (aflibercept); EC 2.7.10.1 (Receptors, Vascular Endothelial Growth Factor); IX6J1063HV (Indocyanine Green); ZL1R02VT79 (Ranibizumab)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1007/s10384-017-0549-2


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[PMID]:29245215
[Au] Autor:Zou BC; Wang FF; Zhao G; Lu XL; Zhang L; Zhao P; Shi HT; Qin B; Guo XD; Zhang J
[Ad] Endereço:aDepartment of Gastroenterology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinabDepartment of Gastroenterology, Xi'an Children's Hospital, Xi'an, Shaanxi, China.
[Ti] Título:A giant and extensive solitary Peutz-Jeghers-type polyp in the antrum of stomach: Case report.
[So] Source:Medicine (Baltimore);96(49):e8466, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: A solitary Peutz-Jeghers-type polyp is a hamartomatous polyp which without either mucocutaneous pigmentation or a family history of Peutz-Jeghers syndrome (PJS). It can occur in all of the gastrointestinal tract, but it is extremely rare in the stomach. PATIENT CONCERNS: A 53-year-old man was admitted to the local hospital with left upper abdominal pain lasting 2 weeks. A gastroscopy showed a giant and extensive bulging lesion on the greater curvature and posterior and anterior walls of the gastric antrum, involving three-quarters of the gastric wall. Endoscopic ultrasonography showed a muscularis mucosa lesion. DIAGNOSES: A solitary Peutz-Jeghers-type polyp in the antrum of stomach. INTERVENTIONS: The patient underwent an endoscopic submucosal dissection (ESD). OUTCOMES: The patient recovered quickly, without any complications. LESSONS: This is the second largest gastric solitary Peutz-Jeghers-polyp reported until now, and the largest gastric solitary Peutz-Jeghers type-polyp treated by endoscope.
[Mh] Termos MeSH primário: Hamartoma/diagnóstico por imagem
Síndrome de Peutz-Jeghers/diagnóstico por imagem
Pólipos/diagnóstico por imagem
Neoplasias Gástricas/diagnóstico por imagem
[Mh] Termos MeSH secundário: Hamartoma/patologia
Seres Humanos
Masculino
Meia-Idade
Síndrome de Peutz-Jeghers/patologia
Pólipos/patologia
Antro Pilórico/diagnóstico por imagem
Neoplasias Gástricas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008466


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[PMID]:29173260
[Au] Autor:Caycedo-Marulanda A; Jiang HY; Kohtakangas EL
[Ad] Endereço:From the Department of Surgery, Health Sciences North, Sudbury, Ont. (Caycedo-Marulanda, Jiang, Kohtakangas); and the Faculty of Medicine, Northern Ontario School of Medicine, Sudbury, Ont. (Caycedo-Marulanda, Jiang, Kohtakangas).
[Ti] Título:Transanal minimally invasive surgery for benign large rectal polyps and early malignant rectal cancers: experience and outcomes from the first Canadian centre to adopt the technique.
[So] Source:Can J Surg;60(6):416-423, 2017 Dec.
[Is] ISSN:1488-2310
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Transanal minimally invasive surgery (TAMIS) has emerged as a relatively new technique in treating early cancer and benign lesion of the rectum. The technique is likely to be widely adopted, surpassing other comparable techniques owing to its simple setup and cost-effectiveness. We assessed the outcomes of TAMIS at our centre. METHODS: We retrospectively reviewed prospectively collected data on 50 patients who underwent TAMIS for benign, malignant T1 or T2 cancers that were unfit for radical surgery over a 4-year period. Outcomes, including 30-day complications and recurrence, as well as our ability to implement and integrate this technique at our centre were assessed. RESULTS: All 50 TAMIS procedures were successful. The average lesion was 7 cm from the anal verge, the average tumour size was 2.5 cm, the average duration of surgery was 73 minutes, the average length of stay was 1.1 days, and the margin negativity was 84%. Major indications in our series included 25 lesions that were too large for endoscopic resection, 14 early cancers or high-grade dysplasia, 10 margin checks postpolypectomy, 6 cases of recurrent polyposis, and 4 medically unfit patients. There were no deaths. The rate of short-term complications, including rectal bleeding, reoperation and urinary retention, was 16%. The rate of long-term complications, including anal incontinence and stenosis, was 4%. Benign and malignant recurrence rates were 2% and 6%, respectively. Overall long-term requirement for invasive procedures, low anterior resection or abdominoperineal resection, was 12%. CONCLUSION: To our knowledge, this is the first Canadian study showing TAMIS to be an efficient and safe procedure for the treatment of well-selected patients with rectal lesions. Outcomes from our centre are comparable with those found in the literature.
[Mh] Termos MeSH primário: Pólipos/cirurgia
Doenças Retais/cirurgia
Neoplasias Retais/cirurgia
Cirurgia Endoscópica Transanal
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
Estadiamento de Neoplasias
Neoplasias Retais/patologia
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:29068974
[Au] Autor:Ioanidis KE; MacNeil SD; Tay KY; Wehrli B
[Ad] Endereço:aDepartment of Otolaryngology-Head and Neck Surgery bDepartment of Medical Imaging cDepartment of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
[Ti] Título:An atypical lipomatous tumor mimicking a giant fibrovascular polyp of the hypopharynx: A case report.
[So] Source:Medicine (Baltimore);96(43):e6927, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Giant fibrovascular polyps (GFVPs) found in the hypopharynx are exceedingly rare. These are benign tumors which are identified by CT or MRI and usually treated based on symptoms. Even more rarely, pathology may identify one of these masses as an atypical lipomatous tumor (ALT). This paper will present a case of an ALT of the hypopharynx that was originally classified as a GFVP, highlighting the difficulty in distinguishing between them and the importance of making the correct diagnosis. PATIENT CONCERNS: An 84-year-old man presented to the emergency department with a 6-month history of a pedunculated hypopharyngeal growth, dysphagia, and intermittent dyspnea. DIAGNOSES: The mass was characterized as a GFVP by barium swallow and MRI. INTERVENTIONS: The hypopharyngeal mass was resected for obstructive symptoms and to confirm the diagnosis. Final pathology found the mass to be more consistent with an atypical lipomatous tumor (ALT). OUTCOMES: The patient's dysphagia and dyspnea resolved. He was free of recurrence at 22 months postoperative. LESSONS: Both GFVPs and ALTs are very rarely found in the hypopharynx but can be easily misclassified as one another. Imaging is useful to initially characterize the mass, but to definitively differentiate between them, pathological analysis is necessary. Although they are rare, it is important to consider both possibilities on the differential for hypopharyngeal masses. Further, accurate analysis is essential to distinguish between them because their definitive management and follow-up is different.
[Mh] Termos MeSH primário: Neoplasias Hipofaríngeas/patologia
Lipoma/patologia
Pólipos/patologia
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Transtornos de Deglutição/etiologia
Diagnóstico Diferencial
Dispneia/etiologia
Seres Humanos
Neoplasias Hipofaríngeas/classificação
Neoplasias Hipofaríngeas/complicações
Neoplasias Hipofaríngeas/cirurgia
Lipoma/classificação
Lipoma/complicações
Lipoma/cirurgia
Imagem por Ressonância Magnética
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006927


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[PMID]:29049725
[Au] Autor:Subhi Y; Krogh Nielsen M; Molbech CR; Oishi A; Singh A; Nissen MH; Sørensen TL
[Ad] Endereço:Clinical Eye Research Division, Department of Ophthalmology, Zealand University Hospital, Roskilde, Denmark.
[Ti] Título:CD11b and CD200 on Circulating Monocytes Differentiate Two Angiographic Subtypes of Polypoidal Choroidal Vasculopathy.
[So] Source:Invest Ophthalmol Vis Sci;58(12):5242-5250, 2017 Oct 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To investigate surface expression of CD11b and CD200 on circulating monocytes in patients with polypoidal choroidal vasculopathy (PCV). Methods: This was a prospective case-control study of patients with PCV (n = 27), age-matched healthy controls (n = 27), and patients with neovascular AMD (n = 49). All participants underwent a comprehensive ocular examination. Fluorescein and indocyanine green angiography were performed in patients suspected of neovascular AMD or PCV. Polypoidal choroidal vasculopathy was angiographically categorized into those with a strong presence of a branching vascular network (BVN) (type 1) or with a faint/no clear presence of a BVN (type 2). Fresh venous blood was stained with fluorescent antibodies for flow cytometric analyses. We compared the percentages of CD11b+, CD200+, and CD11b+CD200+ monocytes between groups of diagnosis and between different angiographic subtypes of PCV. Results: Overall, CD11b+ monocytes were both increased in patients with PCV and neovascular AMD. CD200+ and CD11b+CD200+ monocytes were increased in patients with neovascular AMD. An age-related increase in CD11b+CD200+ monocytes was absent in patients with PCV and neovascular AMD. Patients with PCV type 1 had significantly higher CD11b+, CD200+, and CD11b+CD200+ monocytes, whereas patients with PCV type 2 had levels similar to that in healthy controls. Conclusions: We found that PCV is immunologically heterogeneous with significant differences between angiographic subtypes. Increased CD11b+ and CD200+ monocytes in those with a strong presence of BVN indicate that BVN development may be associated with retinal injury and a VEGF-mediated process that is either reflected or propelled by systemic changes in monocytes.
[Mh] Termos MeSH primário: Antígenos CD/metabolismo
Biomarcadores/metabolismo
Antígeno CD11b/metabolismo
Neovascularização de Coroide/sangue
Monócitos/metabolismo
Pólipos/sangue
[Mh] Termos MeSH secundário: Idoso
Estudos de Casos e Controles
Neovascularização de Coroide/diagnóstico
Corantes/administração & dosagem
Feminino
Citometria de Fluxo
Angiofluoresceinografia
Seres Humanos
Verde de Indocianina/administração & dosagem
Degeneração Macular/sangue
Degeneração Macular/diagnóstico
Masculino
Pólipos/diagnóstico
Estudos Prospectivos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD); 0 (Biomarkers); 0 (CD11b Antigen); 0 (Coloring Agents); 0 (ITGAM protein, human); 0 (antigens, CD200); IX6J1063HV (Indocyanine Green)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22479


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[PMID]:28935332
[Au] Autor:Cockbain AJ; England R; Dexter SPL; Sarela AI
[Ad] Endereço:Department of Upper Gastrointestinal Surgery, St. James's University Hospital, Leeds, United Kingdom; Department of Radiology, St. James's University Hospital, Leeds, United Kingdom. Electronic address: andycockbain@hotmail.com.
[Ti] Título:Surveillance Is Important After Surgical Excision of Giant Fibrovascular Polyps of the Esophagus.
[So] Source:Ann Thorac Surg;104(4):e341-e343, 2017 Oct.
[Is] ISSN:1552-6259
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Giant fibrovascular polyps of the esophagus are rare benign tumors arising from the cervical esophagus or hypopharynx. Radiologic and endoscopic investigation may struggle to identify a stalk or to delineate the tumor as luminal or submucosal in origin. Excision is advised, although the diagnosis, and therefore the optimal operative approach, may not be apparent until the time of operation. Individual case reports describe the technical success of surgical excision but rarely include follow-up. Our case series highlights the range of approaches for surgical excision and also the importance of long-term follow-up because of the risk of recurrence and potential for airway obstruction.
[Mh] Termos MeSH primário: Neoplasias Esofágicas/patologia
Neoplasias Esofágicas/cirurgia
Monitorização Fisiológica/métodos
Pólipos/patologia
Pólipos/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Neoplasias Esofágicas/diagnóstico por imagem
Estenose Esofágica/diagnóstico
Estenose Esofágica/etiologia
Esofagoscopia/métodos
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Pólipos/diagnóstico por imagem
Doenças Raras
Estudos Retrospectivos
Medição de Risco
Amostragem
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE


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[PMID]:28853590
[Au] Autor:Mehdorn AS; Schmidt F; Steinestel K; Wardelmann E; Greulich B; Palmes D; Senninger N
[Ad] Endereço:University of Münster , Germany.
[Ti] Título:Pedunculated, well differentiated liposarcoma of the oesophagus mimicking giant fibrovascular polyp.
[So] Source:Ann R Coll Surg Engl;99(7):e209-e212, 2017 Sep.
[Is] ISSN:1478-7083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We present a rare case of a big oesophageal liposarcoma causing dysphagia and weight loss in a 75-year-old patient. Endoscopically, a pedunculated lesion with subtotal obstruction of the oesophageal lumen had been detected and thoracoabdominal oesophageal resection with gastric sleeve reconstruction was performed. Surprisingly, a liposarcoma of the oesophagus was revealed on histopathological analysis, showing MDM2 overexpression. Oncological follow-up has been uneventful and the patient remains in good clinical shape at 15 months after surgery.
[Mh] Termos MeSH primário: Neoplasias Esofágicas/diagnóstico
Lipossarcoma/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Diagnóstico Diferencial
Neoplasias Esofágicas/diagnóstico por imagem
Neoplasias Esofágicas/patologia
Neoplasias Esofágicas/cirurgia
Esofagectomia
Esôfago/diagnóstico por imagem
Esôfago/patologia
Esôfago/cirurgia
Seres Humanos
Lipossarcoma/diagnóstico por imagem
Lipossarcoma/patologia
Lipossarcoma/cirurgia
Pólipos/diagnóstico
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1308/rcsann.2017.0117


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[PMID]:28828909
[Au] Autor:Song BH; Merchant M; Schloegel L
[Ad] Endereço:1 Department of Head and Neck Surgery, Kaiser Permanente Oakland Medical Center, Oakland, California, USA.
[Ti] Título:Voice Outcomes of Adults Diagnosed with Pediatric Vocal Fold Nodules and Impact of Speech Therapy.
[So] Source:Otolaryngol Head Neck Surg;157(5):824-829, 2017 Nov.
[Is] ISSN:1097-6817
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objective To evaluate the voice outcomes of adults diagnosed with vocal fold nodules (VFNs) as children and to assess the impact of speech therapy on long-term voice outcomes. Study Design Prospective cohort study. Setting Large health care system. Subjects and Methods Subjects diagnosed with VFNs as children between the years 1996 and 2008 were identified within a medical record database of a large health care system. Included subjects were 3 to 12 years old at the time of diagnosis, had a documented laryngeal examination within 90 days of diagnosis, and were ≥18 years as of December 31, 2014. Qualified subjects were contacted by telephone and administered the Vocal Handicap Index-10 (VHI-10) and a 15-item questionnaire inquiring for confounding factors. Results A total of 155 subjects were included, with a mean age of 21.4 years (range, 18-29). The male:female ratio was 2.3:1. Mean VHI-10 score for the entire cohort was 5.4. Mean VHI-10 scores did not differ between those who received speech therapy (6.1) and those who did not (4.5; P = .08). Both groups were similar with respect to confounding risk factors that can contribute to dysphonia, although the no-therapy group had a disproportionately higher number of subjects who consumed >10 alcoholic drinks per week ( P = .01). Conclusion The majority of adults with VFNs as children will achieve a close-to-normal voice quality when they reach adulthood. In our cohort, speech therapy did not appear to have an impact on the long-term voice outcomes.
[Mh] Termos MeSH primário: Pólipos/patologia
Fonoterapia
Prega Vocal/patologia
Distúrbios da Voz/etiologia
Distúrbios da Voz/reabilitação
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Avaliação da Deficiência
Feminino
Seres Humanos
Masculino
Estudos Prospectivos
Recuperação de Função Fisiológica
Fatores de Risco
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.1177/0194599817726285



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