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Pesquisa : C23.550.210.190 [Categoria DeCS]
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  1 / 4016 MEDLINE  
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[PMID]:29368494
[Au] Autor:Stegniy VN; Pishchelko AO; Sibataev AK; Abylkassymova G
[Ti] Título:[Spatial and temporal variations of the chromosomal inversion frequencies across the range of malaria mosquito Anopheles messeae Fall. (Culicidae) during the 40-year monitoring period].
[So] Source:Genetika;52(6):664-71, 2016 Jun.
[Is] ISSN:0016-6758
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The analysis of personal and published data on the frequency dynamics of chromosomal inversions within the range of Anopheles messeae obtained during the period from 1974 through 2014 is presented. The results showed that, in general, across the species range, during the 40 years of genetic monitoring, there was a steady (stationary) clinal distribution of inversions in the first decade (1974­1985). Then, over the period of five years (1986­1990), there was a considerable change in the inversion frequencies in favor of southwestern chromosomal variants (particularly strongly fixed in the Tomsk population), and from 1992 to the present time, these changes remained and were relatively stably reproduced in most parts of the range. It was noted that the jump in warming during the winter of 1981­1982 led to a correlated jump of the southwestern chromosomes in the Tomsk population. In connection with the general tendency toward the increase in average winter temperatures, a sharp decrease in the 2R1 chromosome frequency in the Siberian region and Syktyvkar in the period from 1992 to the present time was observed. There is reason to assume that, over the past decade, the northern boundary of the An. messeae range moved northward to the tundra zone.
[Mh] Termos MeSH primário: Anopheles/genética
Inversão Cromossômica
Cromossomos Politênicos/genética
[Mh] Termos MeSH secundário: Animais
Sibéria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


  2 / 4016 MEDLINE  
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[PMID]:28965848
[Au] Autor:Demaerel W; Hestand MS; Vergaelen E; Swillen A; López-Sánchez M; Pérez-Jurado LA; McDonald-McGinn DM; Zackai E; Emanuel BS; Morrow BE; Breckpot J; Devriendt K; Vermeesch JR; International 22q11.2 Brain and Behavior Consortium
[Ad] Endereço:Department of Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium.
[Ti] Título:Nested Inversion Polymorphisms Predispose Chromosome 22q11.2 to Meiotic Rearrangements.
[So] Source:Am J Hum Genet;101(4):616-622, 2017 Oct 05.
[Is] ISSN:1537-6605
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Inversion polymorphisms between low-copy repeats (LCRs) might predispose chromosomes to meiotic non-allelic homologous recombination (NAHR) events and thus lead to genomic disorders. However, for the 22q11.2 deletion syndrome (22q11.2DS), the most common genomic disorder, no such inversions have been uncovered as of yet. Using fiber-FISH, we demonstrate that parents transmitting the de novo 3 Mb LCR22A-D 22q11.2 deletion, the reciprocal duplication, and the smaller 1.5 Mb LCR22A-B 22q11.2 deletion carry inversions of LCR22B-D or LCR22C-D. Hence, the inversions predispose chromosome 22q11.2 to meiotic rearrangements and increase the individual risk for transmitting rearrangements. Interestingly, the inversions are nested or flanking rather than coinciding with the deletion or duplication sizes. This finding raises the possibility that inversions are a prerequisite not only for 22q11.2 rearrangements but also for all NAHR-mediated genomic disorders.
[Mh] Termos MeSH primário: Inversão Cromossômica
Síndrome de DiGeorge/genética
Predisposição Genética para Doença
Meiose
Polimorfismo de Nucleotídeo Único
[Mh] Termos MeSH secundário: Deleção Cromossômica
Variações do Número de Cópias de DNA
Síndrome de DiGeorge/patologia
Recombinação Homóloga
Seres Humanos
Hibridização in Situ Fluorescente/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE


  3 / 4016 MEDLINE  
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[PMID]:28628615
[Au] Autor:Cossu M; Badel C; Catchpole R; Gadelle D; Marguet E; Barbe V; Forterre P; Oberto J
[Ad] Endereço:Institute for Integrative Biology of the Cell (I2BC), Microbiology Department, CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette, France.
[Ti] Título:Flipping chromosomes in deep-sea archaea.
[So] Source:PLoS Genet;13(6):e1006847, 2017 Jun.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:One of the major mechanisms driving the evolution of all organisms is genomic rearrangement. In hyperthermophilic Archaea of the order Thermococcales, large chromosomal inversions occur so frequently that even closely related genomes are difficult to align. Clearly not resulting from the native homologous recombination machinery, the causative agent of these inversions has remained elusive. We present a model in which genomic inversions are catalyzed by the integrase enzyme encoded by a family of mobile genetic elements. We characterized the integrase from Thermococcus nautili plasmid pTN3 and showed that besides canonical site-specific reactions, it catalyzes low sequence specificity recombination reactions with the same outcome as homologous recombination events on DNA segments as short as 104bp both in vitro and in vivo, in contrast to other known tyrosine recombinases. Through serial culturing, we showed that the integrase-mediated divergence of T. nautili strains occurs at an astonishing rate, with at least four large-scale genomic inversions appearing within 60 generations. Our results and the ubiquitous distribution of pTN3-like integrated elements suggest that a major mechanism of evolution of an entire order of Archaea results from the activity of a selfish mobile genetic element.
[Mh] Termos MeSH primário: Inversão Cromossômica/genética
Evolução Molecular
Integrases/genética
Thermococcales/genética
[Mh] Termos MeSH secundário: Genoma Arqueal
Sequências Repetitivas Dispersas/genética
Plasmídeos/genética
Recombinação Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.7.- (Integrases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1006847


  4 / 4016 MEDLINE  
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[PMID]:28610135
[Au] Autor:Thapa S; Adler PH; Chhetri S; Varma R; Henry W
[Ad] Endereço:P.G. Department of Zoology, Darjeeling Government College, Darjeeling 734101, West Bengal, India.. search4sachin@gmail.com.
[Ti] Título:Chromosomal evidence for a new cryptic species of black fly in the Simulium praelargum complex (Diptera: Simuliidae) from West Bengal, India.
[So] Source:Zootaxa;4244(1):137-144, 2017 Mar 17.
[Is] ISSN:1175-5334
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Analyses of polytene chromosomes revealed a new cryptic species of black fly, Simulium praelargum "IL", in the Simulium (Nevermania) feuerborni group from Darjeeling, West Bengal, India. This new species occurred sympatrically with two other previously recognized species in the S. praelargum complex: Simulium praelargum Datta sensu stricto and Simulium praelargum "IIIL-1.2". Chromosome arms IS, IIS, IIL, and IIIS of the new species showed no differences in banding patterns, compared with the sequences in Simulium praelargum s. s. and Simulium praelargum "IIIL-1.2". Chromosome arm IIIL of the new species was identical to that of S. praelargum s. s., but differed from that of S. praelargum "IIIL-1.2" by two fixed inversions. Chromosome arm IL of the new species differed from that of both species by four fixed inversions: IL-1, IL-2, IL-3, and IL-4. The new species and S. praelargum s. s. lacked a chromocenter, which was present in S. praelargum "IIIL-1.2". Sex chromosomes of the new species were cytologically undifferentiated (X0X0, X0Y0) and all specimens were monomorphic for autosomal inversion polymorphisms. Speciation in the S. feuerborni group, unlike in many other simuliid taxa, did not involve cytological differentiation of sex chromosomes.
[Mh] Termos MeSH primário: Simuliidae
[Mh] Termos MeSH secundário: Animais
Inversão Cromossômica
Índia
Cromossomos Politênicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.11646/zootaxa.4244.1.8


  5 / 4016 MEDLINE  
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[PMID]:28501862
[Au] Autor:Degrandi TM; Del Valle Garnero A; O'Brien PCM; Ferguson-Smith MA; Kretschmer R; de Oliveira EHC; Gunski RJ
[Ad] Endereço:Programa de Pós Graduação em Genética, Laboratório de Citogenética e Genética da Conservação Animal, Universidade Federal do Paraná, Curitiba, Brazil.
[Ti] Título:Chromosome Painting in Trogon s. surrucura (Aves, Trogoniformes) Reveals a Karyotype Derived by Chromosomal Fissions, Fusions, and Inversions.
[So] Source:Cytogenet Genome Res;151(4):208-215, 2017.
[Is] ISSN:1424-859X
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Trogons are forest birds with a wide distribution, being found in Africa, Asia, and America, and are included in the order Trogoniformes, family Trogonidae. Phylogenetic studies using molecular data have not been able to determine the phylogenetic relationship among the different genera of trogons. So far, no cytogenetic data for these birds exist. Hence, the aim of this study was to characterize the karyotype of Trogon surrucura surrucura by means of classical and molecular cytogenetics. We found a diploid chromosome number of 2n = 82, similar to most birds, with several derived features compared to chicken and the putative ancestral avian karyotype. T. s. surrucura showed 3 pairs of microchromosomes bearing 18S rDNA clusters. The Z and W sex chromosomes were of similar size but could readily be identified by morphological differences. Using chromosome painting with whole chromosome probes from Gallus gallus and Leucopternis albicollis, we found that the chromosomes homologous to chicken chromosomes 2 and 5 correspond to 2 different pairs in T. s. surrucura and L. albicollis, due to the occurrence of centric fissions. Paracentric inversions were detected in the segment homologous to chicken chromosome 1q, and we confirmed the recurrence of breakpoints when our results were compared to other species of birds already analyzed by FISH or by in silico genome assembly.
[Mh] Termos MeSH primário: Aves/genética
Inversão Cromossômica/genética
Rearranjo Gênico/genética
[Mh] Termos MeSH secundário: Animais
Coloração Cromossômica/métodos
Diploide
Evolução Molecular
Cariótipo
Cariotipagem/métodos
Filogenia
Cromossomos Sexuais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170515
[St] Status:MEDLINE
[do] DOI:10.1159/000471782


  6 / 4016 MEDLINE  
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[PMID]:28416820
[Au] Autor:Yue JX; Li J; Aigrain L; Hallin J; Persson K; Oliver K; Bergström A; Coupland P; Warringer J; Lagomarsino MC; Fischer G; Durbin R; Liti G
[Ad] Endereço:Université Côte d'Azur, CNRS, INSERM, IRCAN, Nice, France.
[Ti] Título:Contrasting evolutionary genome dynamics between domesticated and wild yeasts.
[So] Source:Nat Genet;49(6):913-924, 2017 Jun.
[Is] ISSN:1546-1718
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Structural rearrangements have long been recognized as an important source of genetic variation, with implications in phenotypic diversity and disease, yet their detailed evolutionary dynamics remain elusive. Here we use long-read sequencing to generate end-to-end genome assemblies for 12 strains representing major subpopulations of the partially domesticated yeast Saccharomyces cerevisiae and its wild relative Saccharomyces paradoxus. These population-level high-quality genomes with comprehensive annotation enable precise definition of chromosomal boundaries between cores and subtelomeres and a high-resolution view of evolutionary genome dynamics. In chromosomal cores, S. paradoxus shows faster accumulation of balanced rearrangements (inversions, reciprocal translocations and transpositions), whereas S. cerevisiae accumulates unbalanced rearrangements (novel insertions, deletions and duplications) more rapidly. In subtelomeres, both species show extensive interchromosomal reshuffling, with a higher tempo in S. cerevisiae. Such striking contrasts between wild and domesticated yeasts are likely to reflect the influence of human activities on structural genome evolution.
[Mh] Termos MeSH primário: Cromossomos Fúngicos
Evolução Molecular
Genoma Fúngico
Saccharomyces/genética
[Mh] Termos MeSH secundário: Evolução Biológica
Inversão Cromossômica
Genoma Mitocondrial/genética
Genômica/métodos
Saccharomyces cerevisiae/genética
Telômero/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1038/ng.3847


  7 / 4016 MEDLINE  
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[PMID]:28375434
[Au] Autor:Rogers HJ; Hsi ED; Tang G; Wang SA; Bueso-Ramos CE; Lubin D; Morrissette JJ; Bagg A; Cherukuri DP; George TI; Peterson L; Liu YC; Mathew S; Orazi A; Hasserjian RP
[Ad] Endereço:From the Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH.
[Ti] Título:Most Myeloid Neoplasms With Deletion of Chromosome 16q Are Distinct From Acute Myeloid Leukemia With Inv(16)(p13.1q22): A Bone Marrow Pathology Group Multicenter Study.
[So] Source:Am J Clin Pathol;147(4):411-419, 2017 Apr 01.
[Is] ISSN:1943-7722
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objectives: Isolated deletion of the long arm of chromosome 16 (del(16q)) is rare in myeloid neoplasms (MNs) and was historically considered a variant of inv(16)(p13.1q22) (inv(16)), a subtype of acute myeloid leukemia (AML) associated with CBFB-MYH11 rearrangement and favorable prognosis. This study aims to determine clinicopathologic characteristics of patients with isolated del(16q) in MNs in comparison to AMLs with isolated inv(16). Methods: Clinicopathologic features were retrospectively reviewed in 18 MNs with del(16q) and 34 AMLs with inv(16) patients from seven institutions. Results: MNs with del(16q) occurred in elderly patients, often as secondary MNs. Blood monocytes and marrow eosinophils were lower in del(16q) than inv(16). Deletion of CBFB but not CBFB-MYH11 rearrangement was confirmed by fluorescence in situ hybridization or reverse transcription polymerase chain reaction in 14 of 14 del(16q) patients. The median overall survival was shorter in del(16q) than in inv(16) patients (12 vs 94 months, log rank P = .0002). Conclusions: Myeloid neoplasms with isolated del(16q) with deletion of the CBFB but lacking CBFB-MYH11 rearrangement should not be considered a variant of the AML-defining inv(16).
[Mh] Termos MeSH primário: Medula Óssea/patologia
Deleção Cromossômica
Inversão Cromossômica
Cromossomos Humanos Par 16
Leucemia Mieloide Aguda/genética
Leucemia Mieloide/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Feminino
Seres Humanos
Leucemia Mieloide/mortalidade
Leucemia Mieloide/patologia
Leucemia Mieloide Aguda/mortalidade
Leucemia Mieloide Aguda/patologia
Masculino
Meia-Idade
Proteínas de Fusão Oncogênicas/genética
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (CBFbeta-MYH11 fusion protein); 0 (Oncogene Proteins, Fusion)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170411
[Lr] Data última revisão:
170411
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE
[do] DOI:10.1093/ajcp/aqx020


  8 / 4016 MEDLINE  
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[PMID]:28360394
[Au] Autor:Banerjee P; Singh BN
[Ad] Endereço:Genetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India. bashisthsingh2004@rediffmail.com.
[Ti] Título:The Drosophila bipectinata species complex: phylogenetic relationship among different members based on chromosomal variations.
[So] Source:J Genet;96(1):97-107, 2017 Mar.
[Is] ISSN:0973-7731
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Making interspecific hybridizations, where possible remains an unparalleled option for studying the intricacies of speciation. In the Drosophila bipectinata species complex comprising of four species, namely D. bipectinata, D. parabipectinata, D. malerkotliana and D. pseudoananassae, interspecific hybrids can be obtained in the laboratory, thus bequeathing an ideal opportunity for studying speciation and phylogeny. With the view of investigating the degree of divergence between each species pair, we planned to study the polytene chromosomes of the F hybrids, as it would mirror the level of compatibility between the genomes of the parental species. Two sets of crosses were made, one involving homozygous strains of all four species from India and the other including homozygous strains from different places across the globe. Polytene chromosomes of F larvae from both sets of crosses had similar configurations. In F larvae from crosses involving D. bipectinata, D. parabipectinata and D. malerkotliana, complex configurations (depicting overlapping inversions) could be detected in different arms. However, they were fairly synapsed, indicating that the differences are only at the level of gene arrangements. The polytene chromosomes of larvae obtained by crossing D. pseudoananassae with the other three species were very thin with gross asynapsis in all the arms, demonstrating that the genome of D. pseudoananassae is widely diverged from rest of the species. The overlapping inversions (reflected in complex configuration), are inferred in the light of earlier chromosomal studies performed in this complex.
[Mh] Termos MeSH primário: Cromossomos de Insetos
Drosophila/classificação
Drosophila/genética
Variação Genética
Filogenia
[Mh] Termos MeSH secundário: Animais
Inversão Cromossômica
Cruzamentos Genéticos
Hibridização Genética
Cromossomos Politênicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE


  9 / 4016 MEDLINE  
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[PMID]:28306537
[Au] Autor:Chen X; Wang X; Dong G; Fu J; Wu W; Jiang Y
[Ad] Endereço:Department of Endocrinology, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, P.R.
[Ti] Título:Clinical features of girls with short stature among inv (9), Turner (45, X) and control individuals.
[So] Source:J Pediatr Endocrinol Metab;30(4):431-436, 2017 Apr 01.
[Is] ISSN:2191-0251
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The clinical significance of pericentric inversion of chromosome 9 [inv (9)] remains unclear. METHODS: This case control study assessed girls with short stature. According to karyotypes, the subjects were divided into inv (9) [46,XX,inv (9)(p12q13) and 46,XX,inv (9)(p11q13)], Turner syndrome (45, X) and control (normal 46, XX) groups, respectively. Detailed clinical features were compared. RESULTS: Height standard deviation score (SDS) values at diagnosis were -2.51±0.58, -3.71±2.12 and -2.5±1.24 for inv (9), (45, X) and control groups, respectively (p=0.022). The inv (9) group showed lower body mass index (BMI) values compared with the (45, X) and control groups (F=5.097, p=0.008). Similar growth hormone deficiency (GHD) incidences were found in all groups. Interestingly, height SDS was positively correlated with mother height and patient BMI SDS (r=0.51, p=0.036; r=0.576, p=0.023, respectively) in the inv (9) group. In the (45, X) group, height SDS was positively correlated with birth weight (r=0.392, p=0.039). CONCLUSIONS: Short stature in inv (9) girls was correlated with low birth weight (LBW) and mother height.
[Mh] Termos MeSH primário: Estatura/genética
Inversão Cromossômica/genética
Nanismo Hipofisário/patologia
Transtornos do Crescimento/patologia
Hormônio do Crescimento Humano/deficiência
Síndrome de Turner/patologia
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Criança
Análise Citogenética
Nanismo Hipofisário/genética
Feminino
Seguimentos
Transtornos do Crescimento/genética
Seres Humanos
Síndrome de Turner/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
12629-01-5 (Human Growth Hormone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE


  10 / 4016 MEDLINE  
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[PMID]:28296677
[Au] Autor:Argani P; Zhang L; Reuter VE; Tickoo SK; Antonescu CR
[Ad] Endereço:Departments of *Pathology †Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD ‡Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY.
[Ti] Título:RBM10-TFE3 Renal Cell Carcinoma: A Potential Diagnostic Pitfall Due to Cryptic Intrachromosomal Xp11.2 Inversion Resulting in False-negative TFE3 FISH.
[So] Source:Am J Surg Pathol;41(5):655-662, 2017 May.
[Is] ISSN:1532-0979
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Xp11 translocation renal cell carcinoma (RCC) are defined by chromosome translocations involving the Xp11 breakpoint which results in one of a variety of TFE3 gene fusions. TFE3 break-apart florescence in situ hybridization (FISH) assays are generally preferred to TFE3 immunohistochemistry (IHC) as a means of confirming the diagnosis in archival material, as FISH is less sensitive to the variable fixation which can result in false positive or false negative IHC. Prompted by a case report in the cytogenetics literature, we identify 3 cases of Xp11 translocation RCC characterized by a subtle chromosomal inversion involving the short arm of the X chromosome, resulting in an RBM10-TFE3 gene fusion. TFE3 rearrangement was not detected by conventional TFE3 break-apart FISH, but was suggested by strong diffuse TFE3 immunoreactivity in a clean background. We then developed novel fosmid probes to detect the RBM10-TFE3 gene fusion in archival material. These cases validate RBM10-TFE3 as a recurrent gene fusion in Xp11 translocation RCC, illustrate a source of false-negative TFE3 break-apart FISH, and highlight the complementary role of TFE3 IHC and TFE3 FISH.
[Mh] Termos MeSH primário: Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos/genética
Biomarcadores Tumorais/genética
Carcinoma de Células Renais/genética
Inversão Cromossômica
Cromossomos Humanos X
Fusão Gênica
Hibridização in Situ Fluorescente
Neoplasias Renais/genética
Proteínas de Ligação a RNA/genética
[Mh] Termos MeSH secundário: Baltimore
Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos/análise
Biomarcadores Tumorais/análise
Carcinoma de Células Renais/química
Carcinoma de Células Renais/patologia
Carcinoma de Células Renais/cirurgia
Catepsina K/análise
Reações Falso-Negativas
Feminino
Predisposição Genética para Doença
Seres Humanos
Imuno-Histoquímica
Neoplasias Renais/química
Neoplasias Renais/patologia
Neoplasias Renais/cirurgia
Masculino
Meia-Idade
Nefrectomia
Cidade de Nova Iorque
Valor Preditivo dos Testes
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors); 0 (Biomarkers, Tumor); 0 (RBM10 protein, human); 0 (RNA-Binding Proteins); 0 (TFE3 protein, human); EC 3.4.22.38 (CTSK protein, human); EC 3.4.22.38 (Cathepsin K)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.1097/PAS.0000000000000835



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