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  1 / 17203 MEDLINE  
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[PMID]:29295990
[Au] Autor:Bell CG; Gao F; Yuan W; Roos L; Acton RJ; Xia Y; Bell J; Ward K; Mangino M; Hysi PG; Wang J; Spector TD
[Ad] Endereço:Department of Twin Research & Genetic Epidemiology, King's College London, London, SE1 7EH, UK. cgb@mrc.soton.ac.uk.
[Ti] Título:Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci.
[So] Source:Nat Commun;9(1):8, 2018 01 02.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Integrating epigenetic data with genome-wide association study (GWAS) results can reveal disease mechanisms. The genome sequence itself also shapes the epigenome, with CpG density and transcription factor binding sites (TFBSs) strongly encoding the DNA methylome. Therefore, genetic polymorphism impacts on the observed epigenome. Furthermore, large genetic variants alter epigenetic signal dosage. Here, we identify DNA methylation variability between GWAS-SNP risk and non-risk haplotypes. In three subsets comprising 3128 MeDIP-seq peripheral-blood DNA methylomes, we find 7173 consistent and functionally enriched Differentially Methylated Regions. 36.8% can be attributed to common non-SNP genetic variants. CpG-SNPs, as well as facilitative TFBS-motifs, are also enriched. Highlighting their functional potential, CpG-SNPs strongly associate with allele-specific DNase-I hypersensitivity sites. Our results demonstrate strong DNA methylation allelic differences driven by obligatory or facilitative genetic effects, with potential direct or regional disease-related repercussions. These allelic variations require disentangling from pure tissue-specific modifications, may influence array studies, and imply underestimated population variability in current reference epigenomes.
[Mh] Termos MeSH primário: Metilação de DNA
Doença/genética
Variação Genética
Estudo de Associação Genômica Ampla/métodos
[Mh] Termos MeSH secundário: Alelos
Ilhas de CpG/genética
Epigênese Genética
Predisposição Genética para Doença/genética
Genoma Humano/genética
Haplótipos
Sequenciamento de Nucleotídeos em Larga Escala/métodos
Seres Humanos
Polimorfismo de Nucleotídeo Único
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-01586-1


  2 / 17203 MEDLINE  
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[PMID]:29335400
[Au] Autor:Zhu Z; Zheng Z; Zhang F; Wu Y; Trzaskowski M; Maier R; Robinson MR; McGrath JJ; Visscher PM; Wray NR; Yang J
[Ad] Endereço:Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.
[Ti] Título:Causal associations between risk factors and common diseases inferred from GWAS summary data.
[So] Source:Nat Commun;9(1):224, 2018 01 15.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Health risk factors such as body mass index (BMI) and serum cholesterol are associated with many common diseases. It often remains unclear whether the risk factors are cause or consequence of disease, or whether the associations are the result of confounding. We develop and apply a method (called GSMR) that performs a multi-SNP Mendelian randomization analysis using summary-level data from genome-wide association studies to test the causal associations of BMI, waist-to-hip ratio, serum cholesterols, blood pressures, height, and years of schooling (EduYears) with common diseases (sample sizes of up to 405,072). We identify a number of causal associations including a protective effect of LDL-cholesterol against type-2 diabetes (T2D) that might explain the side effects of statins on T2D, a protective effect of EduYears against Alzheimer's disease, and bidirectional associations with opposite effects (e.g., higher BMI increases the risk of T2D but the effect of T2D on BMI is negative).
[Mh] Termos MeSH primário: Índice de Massa Corporal
Colesterol/sangue
Doença/genética
Estudo de Associação Genômica Ampla/métodos
[Mh] Termos MeSH secundário: Doença de Alzheimer/sangue
Doença de Alzheimer/genética
LDL-Colesterol/sangue
Diabetes Mellitus Tipo 2/sangue
Diabetes Mellitus Tipo 2/genética
Doença/etiologia
Seres Humanos
Análise da Randomização Mendeliana
Polimorfismo de Nucleotídeo Único
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cholesterol, LDL); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180117
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02317-2


  3 / 17203 MEDLINE  
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[PMID]:28746974
[Au] Autor:Sheinberger J; Shav-Tal Y
[Ad] Endereço:The Mina & Everard Goodman Faculty of Life Sciences, Institute of Nanotechnology, Bar-Ilan University, Ramat Gan, Israel.
[Ti] Título:mRNPs meet stress granules.
[So] Source:FEBS Lett;591(17):2534-2542, 2017 09.
[Is] ISSN:1873-3468
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Stress granules are cytoplasmic structures that form in response to a variety of cellular stresses. They contain mRNAs and many proteins including numerous types of RNA-binding proteins, and have been studied in connection to major cellular events such as protein synthesis as well as disease. Despite the well-known fact that stress granules encapsulate mRNPs (mRNA-protein complexes), much of the research has naturally focused on the protein components of stress granules. The specific details of mRNP entry into and exit from stress granules and the functional reasons for these dynamics are not fully understood. Here, we review studies that have concentrated on the aspects of mRNP accumulation in stress granules and produced quantitative data concerning mRNP/stress granule interactions.
[Mh] Termos MeSH primário: Grânulos Citoplasmáticos/metabolismo
Ribonucleoproteínas/metabolismo
[Mh] Termos MeSH secundário: Animais
Doença/genética
Seres Humanos
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RNA, Messenger); 0 (Ribonucleoproteins); 0 (messenger ribonucleoprotein)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1002/1873-3468.12765


  4 / 17203 MEDLINE  
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[PMID]:29428128
[Au] Autor:Tia N; Singh AK; Pandey P; Azad CS; Chaudhary P; Gambhir IS
[Ad] Endereço:Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
[Ti] Título:Role of Forkhead Box O (FOXO) transcription factor in aging and diseases.
[So] Source:Gene;648:97-105, 2018 Mar 30.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Fork head box O (FOXO) transcription factor is a key player in an evolutionarily conserved pathway. The mammalian FOXO family consists of FOXO1, 3, 4 and 6, are highly similar in their structure, function and regulation. To maintain optimum body function, the organisms have developed complex mechanisms for homeostasis. Importantly, it is well known that when these mechanisms dysregulate it results in the development of age-related disease. FOXO proteins are involved in a diverse cellular function and also have clinical significance including cell cycle arrest, cell differentiation, tumour suppression, DNA repair, longevity, diabetic complications, immunity, wound healing, regulation of metabolism and thus treatment of several types of diseases. By the combinations of post-translational modifications FOXO's serve as a 'molecular code' to sense external stimuli and recruit it as to specific regions of the genome and provide an integrated cellular response to changing physiological conditions. Akt/Protein kinase B a signaling pathway as a main regulator of FOXO to perform a diverse function in organisms. The present review summarizes the molecular and clinical aspects of FOXO transcription factor. And also elaborate the interaction of FOXO with the nucleosome remodelling complex to target genes, which is essential to cellular homeostasis.
[Mh] Termos MeSH primário: Envelhecimento/genética
Doença/genética
Fatores de Transcrição Forkhead/genética
Regulação da Expressão Gênica
[Mh] Termos MeSH secundário: Envelhecimento/metabolismo
Animais
Fenômenos Fisiológicos Celulares/genética
Fatores de Transcrição Forkhead/metabolismo
Seres Humanos
Longevidade/genética
Isoformas de Proteínas/genética
Isoformas de Proteínas/metabolismo
Transdução de Sinais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Forkhead Transcription Factors); 0 (Protein Isoforms)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180212
[St] Status:MEDLINE


  5 / 17203 MEDLINE  
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Texto completo SciELO Colômbia
Texto completo SciELO Saúde Pública
[PMID]:28453059
[Au] Autor:Santoro-Lamelas V
[Ad] Endereço:Universidad de Barcelona, Barcelona, España, vsantorol@ub.edu.
[Ti] Título:[Public health in the health-disease continuum: an analysis from a professional perspective].
[Ti] Título:La salud pública en el continuo salud-enfermedad: un análisis desde la mirada profesional..
[So] Source:Rev Salud Publica (Bogota);18(4):530-542, 2016 Aug.
[Is] ISSN:0124-0064
[Cp] País de publicação:Colombia
[La] Idioma:spa
[Ab] Resumo:Objective To explore the components that health professionals use to build and define the concept of Public Health as a specific area of knowledge and intervention within public health policies. Method A qualitative analysis of content was performed based on 20 semi-structured interviews with health professionals participating in the demonstration project conducted by the Public Health Agency of Garrotxa in Catalonia, Spain (2009-2012). Results Health professionals use the health-disease continuum to provide guidance to all State policies on health: public health is usually related to health and care regarding disease. Also, professionals contrast public health against health care to define and delineate each intervention area based on the approach, the objectives, the demand, the timing, the invisibility and the consistency. Discussion The continuum health-disease is a relevant element to guide public health policies. It is necessary to develop the concept of wellbeing to act under a positive view of health. Moreover, recognizing the multiplicity of elements that affect public health makes it permeable to the initiatives of other institutions, while they turn to Public Health in other areas of intervention.
[Mh] Termos MeSH primário: Doença
Pessoal de Saúde
Serviços de Saúde
Saúde Pública
[Mh] Termos MeSH secundário: Assistência à Saúde
Política de Saúde
Seres Humanos
Pesquisa Qualitativa
Espanha
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  6 / 17203 MEDLINE  
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[PMID]:29300785
[Au] Autor:Ayele AA; Mekuria AB; Tegegn HG; Gebresillassie BM; Mekonnen AB; Erku DA
[Ad] Endereço:Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
[Ti] Título:Management of minor ailments in a community pharmacy setting: Findings from simulated visits and qualitative study in Gondar town, Ethiopia.
[So] Source:PLoS One;13(1):e0190583, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Community pharmacy professionals are being widely accepted as sources of treatment and advice for managing minor ailments, largely owing to their location at the heart of the community. The aim of the present study was, therefore, to document the involvement of community pharmacy professionals in the management of minor ailments and perceived barriers that limit their provision of such services. Simulated patient (SP) visits combined with a qualitative study using in-depth interviews was conducted among community pharmacy professionals in Gondar town, Northwest Ethiopia. Scenarios of three different minor ailments (uncomplicated upper respiratory tract infection, back pain and acute diarrhea) were selected and results were reported as percentages. Pharmacy professionals were also interviewed about the barriers in the management of minor ailments. Out of 66 simulated visits, 61 cases (92.4%) provided one or more medications to the SPs. Pharmacy professionals in 16 visits asked SPs information on details of symptoms and past medical and medication history. Ibuprofen alone or in combination with paracetamol was the most commonly dispensed analgesics for back pain. Oral rehydration fluid (ORS) with zinc was the most frequently dispensed medication (33.3%) for the management of acute diarrhea followed by mebendazole (23.9%). Moreover, amoxicillin-clavulanic acid capsule (35%) followed by Amoxicillin (25%) were the most commonly dispensed antibiotics for uncomplicated upper respiratory tract infection. Lack of clinical training and poor community awareness towards the role of community pharmacists in the management of minor ailments were the main barriers for the provision of minor ailment management by community pharmacy professionals. Overall, community pharmacists provided inadequate therapy for the simulated minor ailments. Lack of access to clinical training and poor community awareness were the most commonly cited barriers for providing such services. So as to improve community pharmacists' involvement in managing minor ailments and optimize the contribution of pharmacists, interventions should focus on overcoming the identified barriers.
[Mh] Termos MeSH primário: Serviços Comunitários de Farmácia/organização & administração
[Mh] Termos MeSH secundário: Doença/classificação
Tratamento Farmacológico
Etiópia
Pesquisa Qualitativa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190583


  7 / 17203 MEDLINE  
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[PMID]:28743674
[Au] Autor:da Costa PJ; Menezes J; Romão L
[Ad] Endereço:Department of Human Genetics, Instituto Nacional de Saúde Doutor Ricardo Jorge, Lisbon, Portugal; Biosystems & Integrative Sciences Institute (BioISI), Faculdade de Ciências, Universidade de Lisboa, Lisbon, Portugal.
[Ti] Título:The role of alternative splicing coupled to nonsense-mediated mRNA decay in human disease.
[So] Source:Int J Biochem Cell Biol;91(Pt B):168-175, 2017 10.
[Is] ISSN:1878-5875
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Alternative pre-mRNA splicing (AS) affects gene expression as it generates proteome diversity. Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and selectively degrades mRNAs carrying premature translation-termination codons (PTCs), preventing the production of truncated proteins that could result in disease. Several studies have also implicated NMD in the regulation of steady-state levels of physiological mRNAs. In addition, it is known that several regulated AS events do not lead to generation of protein products, as they lead to transcripts that carry PTCs and thus, they are committed to NMD. Indeed, an estimated one-third of naturally occurring, alternatively spliced mRNAs is targeted for NMD, being AS coupled to NMD (AS-NMD) an efficient strategy to regulate gene expression. In this review, we will focus on how AS mechanism operates and how can be coupled to NMD to fine-tune gene expression levels. Furthermore, we will demonstrate the physiological significance of the interplay among AS and NMD in human disease, such as cancer and neurological disorders. The understanding of how AS-NMD orchestrates expression of vital genes is of utmost importance for the advance in diagnosis, prognosis and treatment of many human disorders.
[Mh] Termos MeSH primário: Processamento Alternativo
Doença/genética
Degradação do RNAm Mediada por Códon sem Sentido
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


  8 / 17203 MEDLINE  
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[PMID]:29281665
[Au] Autor:Bergmeir C; Bilgrami I; Bain C; Webb GI; Orosz J; Pilcher D
[Ad] Endereço:Faculty of Information Technology, Monash University, Clayton, Australia.
[Ti] Título:Designing a more efficient, effective and safe Medical Emergency Team (MET) service using data analysis.
[So] Source:PLoS One;12(12):e0188688, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Hospitals have seen a rise in Medical Emergency Team (MET) reviews. We hypothesised that the commonest MET calls result in similar treatments. Our aim was to design a pre-emptive management algorithm that allowed direct institution of treatment to patients without having to wait for attendance of the MET team and to model its potential impact on MET call incidence and patient outcomes. METHODS: Data was extracted for all MET calls from the hospital database. Association rule data mining techniques were used to identify the most common combinations of MET call causes, outcomes and therapies. RESULTS: There were 13,656 MET calls during the 34-month study period in 7936 patients. The most common MET call was for hypotension [31%, (2459/7936)]. These MET calls were strongly associated with the immediate administration of intra-venous fluid (70% [1714/2459] v 13% [739/5477] p<0.001), unless the patient was located on a respiratory ward (adjusted OR 0.41 [95%CI 0.25-0.67] p<0.001), had a cardiac cause for admission (adjusted OR 0.61 [95%CI 0.50-0.75] p<0.001) or was under the care of the heart failure team (adjusted OR 0.29 [95%CI 0.19-0.42] p<0.001). Modelling the effect of a pre-emptive management algorithm for immediate fluid administration without MET activation on data from a test period of 24 months following the study period, suggested it would lead to a 68.7% (2541/3697) reduction in MET calls for hypotension and a 19.6% (2541/12938) reduction in total METs without adverse effects on patients. CONCLUSION: Routinely collected data and analytic techniques can be used to develop a pre-emptive management algorithm to administer intravenous fluid therapy to a specific group of hypotensive patients without the need to initiate a MET call. This could both lead to earlier treatment for the patient and less total MET calls.
[Mh] Termos MeSH primário: Eficiência Organizacional
Serviço Hospitalar de Emergência/organização & administração
Equipe de Respostas Rápidas de Hospitais/organização & administração
Segurança do Paciente
[Mh] Termos MeSH secundário: Algoritmos
Interpretação Estatística de Dados
Doença/classificação
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188688


  9 / 17203 MEDLINE  
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[PMID]:29267319
[Au] Autor:Pinichka C; Makka N; Sukkumnoed D; Chariyalertsak S; Inchai P; Bundhamcharoen K
[Ad] Endereço:International Health Policy Program, Ministry of Public Health, Nonthaburi, Thailand.
[Ti] Título:Burden of disease attributed to ambient air pollution in Thailand: A GIS-based approach.
[So] Source:PLoS One;12(12):e0189909, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Growing urbanisation and population requiring enhanced electricity generation as well as the increasing numbers of fossil fuel in Thailand pose important challenges to air quality management which impacts on the health of the population. Mortality attributed to ambient air pollution is one of the sustainable development goals (SDGs). We estimated the spatial pattern of mortality burden attributable to selected ambient air pollution in 2009 based on the empirical evidence in Thailand. METHODS: We estimated the burden of disease attributable to ambient air pollution based on the comparative risk assessment (CRA) framework developed by the World Health Organization (WHO) and the Global Burden of Disease study (GBD). We integrated geographical information systems (GIS)-based exposure assessments into spatial interpolation models to estimate ambient air pollutant concentrations, the population distribution of exposure and the concentration-response (CR) relationship to quantify ambient air pollution exposure and associated mortality. We obtained air quality data from the Pollution Control Department (PCD) of Thailand surface air pollution monitoring network sources and estimated the CR relationship between relative risk (RR) and concentration of air pollutants from the epidemiological literature. RESULTS: We estimated 650-38,410 ambient air pollution-related fatalities and 160-5,982 fatalities that could have been avoided with a 20 reduction in ambient air pollutant concentrations. The summation of population-attributable fraction (PAF) of the disease burden for all-causes mortality in adults due to NO2 and PM2.5 were the highest among all air pollutants at 10% and 7.5%, respectively. The PAF summation of PM2.5 for lung cancer and cardiovascular disease were 16.8% and 14.6% respectively and the PAF summations of mortality attributable to PM10 was 3.4% for all-causes mortality, 1.7% for respiratory and 3.8% for cardiovascular mortality, while the PAF summation of mortality attributable to NO2 was 7.8% for respiratory mortality in Thailand. CONCLUSION: Mortality due to ambient air pollution in Thailand varies across the country. Geographical distribution estimates can identify high exposure areas for planners and policy-makers. Our results suggest that the benefits of a 20% reduction in ambient air pollution concentration could prevent up to 25% of avoidable fatalities each year in all-causes, respiratory and cardiovascular categories. Furthermore, our findings can provide guidelines for future epidemiological investigations and policy decisions to achieve the SDGs.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/toxicidade
Exposição Ambiental
Sistemas de Informação Geográfica
[Mh] Termos MeSH secundário: Doença
Seres Humanos
Medição de Risco
Tailândia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Air Pollutants)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189909


  10 / 17203 MEDLINE  
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[PMID]:29236741
[Au] Autor:Abera SF; Gebru AA; Biesalski HK; Ejeta G; Wienke A; Scherbaum V; Kantelhardt EJ
[Ad] Endereço:Institute of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany.
[Ti] Título:Social determinants of adult mortality from non-communicable diseases in northern Ethiopia, 2009-2015: Evidence from health and demographic surveillance site.
[So] Source:PLoS One;12(12):e0188968, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: In developing countries, mortality and disability from non-communicable diseases (NCDs) is rising considerably. The effect of social determinants of NCDs-attributed mortality, from the context of developing countries, is poorly understood. This study examines the burden and socio-economic determinants of adult mortality attributed to NCDs in eastern Tigray, Ethiopia. METHODS: We followed 45,982 adults implementing a community based dynamic cohort design recording mortality events from September 2009 to April 2015. A physician review based Verbal autopsy was used to identify the most probable causes of death. Multivariable Cox proportional hazards regression was performed to identify social determinants of NCD mortality. RESULTS: Across the 193,758.7 person-years, we recorded 1,091 adult deaths. Compared to communicable diseases, NCDs accounted for a slightly higher proportion of adult deaths; 33% vs 34.5% respectively. The incidence density rate (IDR) of NCD attributed mortality was 194.1 deaths (IDR = 194.1; 95% CI = 175.4, 214.7) per 100,000 person-years. One hundred fifty-seven (41.8%), 68 (18.1%) and 34 (9%) of the 376 NCD deaths were due to cardiovascular disease, cancer and renal failure, respectively. In the multivariable analysis, age per 5-year increase (HR = 1.35; 95% CI: 1.30, 1.41), and extended family and non-family household members (HR = 2.86; 95% CI: 2.05, 3.98) compared to household heads were associated with a significantly increased hazard of NCD mortality. Although the difference was not statistically significant, compared to poor adults, those who were wealthy had a 15% (HR = 0.85; 95% CI: 0.65, 1.11) lower hazard of mortality from NCDs. On the other hand, literate adults (HR = 0.35; 95% CI: 0.13, 0.9) had a significantly decreased hazard of NCD attributed mortality compared to those adults who were unable to read and write. The effect of literacy was modified by age and its effect reduced by 18% for every 5-year increase of age among literate adults. CONCLUSION: In summary, the study indicates that double mortality burden from both NCDs and communicable diseases was evident in northern rural Ethiopia. Public health intervention measures that prioritise disadvantaged NCD patients such as those who are unable to read and write, the elders, the extended family and non-family household co-residents could significantly reduce NCD mortality among the adult population.
[Mh] Termos MeSH primário: Mortalidade
Vigilância da População
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Estudos de Coortes
Demografia
Doença/classificação
Etiópia/epidemiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188968



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