Base de dados : MEDLINE
Pesquisa : C23.550.291.890 [Categoria DeCS]
Referências encontradas : 1165 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 117 ir para página                         

  1 / 1165 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29225048
[Au] Autor:Gao JF; Gao Y; Qiu JH; Chang QC; Zhang Y; Fang M; Wang CR
[Ad] Endereço:College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province 163319, PR China; Department of Parasitology, Heilongjiang Institute of Veterinary Science, Qiqihar, Heilongjiang Province, PR China.
[Ti] Título:De novo assembly and functional annotations of the transcriptome of Metorchis orientalis (trematoda: Opisthorchiidae).
[So] Source:Exp Parasitol;184:90-96, 2018 Jan.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Metorchis orientalis is a neglected zoonotic parasite, living in the gallbladder and bile duct of poultry and some mammals as well as humans. In spite of its economic and medical importance, the information known about the transcriptome and genome of M. orientalis is limited. In this study, we performed de novo sequencing, transcriptome assembly and functional annotations of the adult M. orientalis, obtained about 77.4 million high-quality clean reads, among which the length of the transcript contigs ranged from 100 to 11,249 nt with mean length of 373 nt and N50 length of 919 nt. We then assembled 31,943 unigenes, of which 20,009 (62.6%) were annotated by BLASTn and BLASTx searches against the available database. Among these unigenes, 19,795 (62.0%), 3407 (10.7%), 10,620 (33.2%) of them had significant similarity in the NR, NT and Swiss-Prot databases, respectively; 5744 (18.0%) and 4678 (14.6%) unigenes were assigned to GO and COG, respectively; and 9099 (28.5%) unigenes were identified and mapped onto 256 pathways in the KEGG Pathway database. Furthermore, we found that 98 (1.08%) unigenes were related to bile secretion and 5 (0.05%) to primary bile acid biosynthesis pathways category. The characterization of these transcriptomic data has implications for the better understanding of the biology of M. orientalis, and will facilitate the development of intervention agents for this and other pathogenic flukes of human and animal health significance.
[Mh] Termos MeSH primário: Doenças Negligenciadas/parasitologia
Opisthorchidae/fisiologia
Transcriptoma
Infecções por Trematódeos/parasitologia
Zoonoses/parasitologia
[Mh] Termos MeSH secundário: Animais
Ductos Biliares/parasitologia
Biologia Computacional
DNA Complementar/biossíntese
Patos/parasitologia
Doenças dos Peixes/parasitologia
Doenças dos Peixes/transmissão
Peixes
Vesícula Biliar/parasitologia
Sequenciamento de Nucleotídeos em Larga Escala
Seres Humanos
Opisthorchidae/genética
Doenças das Aves Domésticas/parasitologia
RNA de Helmintos/genética
RNA de Helmintos/isolamento & purificação
RNA Mensageiro/genética
RNA Mensageiro/isolamento & purificação
Sequenciamento Completo do Exoma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Complementary); 0 (RNA, Helminth); 0 (RNA, Messenger)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


  2 / 1165 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
[PMID]:29186255
[Au] Autor:Andrade TCPC; Martins TY; Vieira BC; Santiago TM; Soares CT; Barreto JA
[Ad] Endereço:Department of Dermatology at Instituto Lauro de Souza Lima (ILSL) - Bauru (SP), Brazil.
[Ti] Título:Lepromatous leprosy simulating rheumatoid arthritis - Report of a neglected disease.
[So] Source:An Bras Dermatol;92(3):389-391, 2017 May-Jun.
[Is] ISSN:1806-4841
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Brazil has the second largest number of leprosy cases in the world; nevertheless, late diagnosis is common. We report the case of a male patient with pain and numbness in both hands and feet for six years with positive rheumatoid factor and anticardiolipin under rheumatoid arthritis treatment for five years. Examination revealed diffuse cutaneous infiltration and leonine facies, characteristic features of lepromatous leprosy. Autoantibodies such as rheumatoid factor and anticardiolipin are markers of rheumatic autoimmune diseases, but their presence is also described in leprosy. We report the present case in order to alert health professionals to remember leprosy, even in areas where the disease is considered eliminated as a public health problem, avoiding misinterpretations of serologic findings and misdiagnosis.
[Mh] Termos MeSH primário: Artrite Reumatoide/diagnóstico
Hanseníase Virchowiana/diagnóstico
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Seres Humanos
Hanseníase Virchowiana/tratamento farmacológico
Hanseníase Virchowiana/patologia
Masculino
Meia-Idade
Doenças Negligenciadas/diagnóstico
Doenças Negligenciadas/tratamento farmacológico
Doenças Negligenciadas/patologia
[Pt] Tipo de publicação:CASE REPORTS
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE


  3 / 1165 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29324858
[Au] Autor:Deribe K; Beng AA; Cano J; Njouendo AJ; Fru-Cho J; Awah AR; Eyong ME; Chounna Ndongmo PW; Giorgi E; Pigott DM; Golding N; Pullan RL; Noor AM; Enquselassie F; Murray CJL; Brooker SJ; Hay SI; Enyong P; Newport MJ; Wanji S; Davey G
[Ad] Endereço:Wellcome Trust Brighton and Sussex Centre for Global Health Research, Brighton and Sussex Medical School, Brighton, United Kingdom.
[Ti] Título:Mapping the geographical distribution of podoconiosis in Cameroon using parasitological, serological, and clinical evidence to exclude other causes of lymphedema.
[So] Source:PLoS Negl Trop Dis;12(1):e0006126, 2018 01.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Podoconiosis is a non-filarial elephantiasis, which causes massive swelling of the lower legs. It was identified as a neglected tropical disease by WHO in 2011. Understanding of the geographical distribution of the disease is incomplete. As part of a global mapping of podoconiosis, this study was conducted in Cameroon to map the distribution of the disease. This mapping work will help to generate data on the geographical distribution of podoconiosis in Cameroon and contribute to the global atlas of podoconiosis. METHODS: We used a multi-stage sampling design with stratification of the country by environmental risk of podoconiosis. We sampled 76 villages from 40 health districts from the ten Regions of Cameroon. All individuals of 15-years old or older in the village were surveyed house-to-house and screened for lymphedema. A clinical algorithm was used to reliably diagnose podoconiosis, excluding filarial-associated lymphedema. Individuals with lymphoedema were tested for circulating Wuchereria bancrofti antigen and specific IgG4 using the Alere Filariasis Test Strips (FTS) test and the Standard Diagnostics (SD) BIOLINE lymphatic filariasis IgG4 test (Wb123) respectively, in addition to thick blood films. Presence of DNA specific to W. bancrofti was checked on night blood using a qPCR technique. PRINCIPAL FINDINGS: Overall, 10,178 individuals from 4,603 households participated in the study. In total, 83 individuals with lymphedema were identified. Of the 83 individuals with lymphedema, two were found to be FTS positive and all were negative using the Wb123 test. No microfilaria of W. bancrofti were found in the night blood of any individual with clinical lymphedema. None were found to be positive for W. bancrofti using qPCR. Of the two FTS positive cases, one was positive for Mansonella perstans DNA, while the other harbored Loa loa microfilaria. Overall, 52 people with podoconiosis were identified after applying the clinical algorithm. The overall prevalence of podoconiosis was found to be 0.5% (95% [confidence interval] CI; 0.4-0.7). At least one case of podoconiosis was found in every region of Cameroon except the two surveyed villages in Adamawa. Of the 40 health districts surveyed, 17 districts had no cases of podoconiosis; in 15 districts, mean prevalence was between 0.2% and 1.0%; and in the remaining eight, mean prevalence was between 1.2% and 2.7%. CONCLUSIONS: Our investigation has demonstrated low prevalence but almost nationwide distribution of podoconiosis in Cameroon. Designing a podoconiosis control program is a vital next step. A health system response to the burden of podoconiosis is important, through case surveillance and morbidity management services.
[Mh] Termos MeSH primário: Anticorpos Antiprotozoários/sangue
Antígenos de Helmintos/imunologia
Elefantíase/epidemiologia
Linfedema/epidemiologia
Doenças Negligenciadas/epidemiologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Antiprotozoários/imunologia
Camarões/epidemiologia
Elefantíase/diagnóstico
Geografia
Seres Humanos
Imunoglobulina G/sangue
Imunoglobulina G/imunologia
Linfedema/diagnóstico
Linfedema/parasitologia
Mansonella/isolamento & purificação
Doenças Negligenciadas/diagnóstico
Wuchereria bancrofti/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Protozoan); 0 (Antigens, Helminth); 0 (Immunoglobulin G); 0 (Wuchereria antigen)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006126


  4 / 1165 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29342389
[Au] Autor:Bloom BR
[Ad] Endereço:From the Departments of Immunology and Infectious Diseases and Global Health and Population, Harvard T.H. Chan School of Public Health, Boston.
[Ti] Título:A Neglected Epidemic.
[So] Source:N Engl J Med;378(3):291-293, 2018 01 18.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Epidemias
Doenças Negligenciadas/epidemiologia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:EDITORIAL; COMMENT
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMe1714609


  5 / 1165 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29303718
[Au] Autor:Savioli L; Daumerie D
[Ad] Endereço:Former Director, Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland. Electronic address: docsavioli@gmail.com.
[Ti] Título:WHO leadership is essential for the elimination of NTDs.
[So] Source:Lancet;390(10114):2765, 2018 12 23.
[Is] ISSN:1474-547X
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Liderança
Doenças Negligenciadas/prevenção & controle
Organização Mundial da Saúde
[Mh] Termos MeSH secundário: Erradicação de Doenças
Dracunculíase/prevenção & controle
Infecções por Uncinaria/prevenção & controle
Seres Humanos
Cooperação Internacional
Esquistossomose Urinária/prevenção & controle
Medicina Tropical
[Pt] Tipo de publicação:LETTER
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180117
[Lr] Data última revisão:
180117
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE


  6 / 1165 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29267282
[Au] Autor:Hotez PJ
[Ad] Endereço:Texas Children's Center for Vaccine Development, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America.
[Ti] Título:Ten failings in global neglected tropical diseases control.
[So] Source:PLoS Negl Trop Dis;11(12):e0005896, 2017 12.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Saúde Global
Doenças Negligenciadas/prevenção & controle
Medicina Tropical
[Mh] Termos MeSH secundário: Doença de Chagas/tratamento farmacológico
Mudança Climática
Seres Humanos
Hanseníase/prevenção & controle
Esquistossomose Urinária/tratamento farmacológico
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180111
[Lr] Data última revisão:
180111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005896


  7 / 1165 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29232692
[Au] Autor:Cox JT; Mkocha H; Munoz B; West SK
[Ad] Endereço:Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, Maryland, United States of America.
[Ti] Título:Trachomatous scarring among children in a formerly hyper-endemic district of Tanzania.
[So] Source:PLoS Negl Trop Dis;11(12):e0006085, 2017 12.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Associations between repeated ocular infections with Chlamydia trachomatis in childhood and conjunctival scarring in adulthood are well established. Trachomatous scarring (TS) in children has also been observed in hyper-endemic areas, but data are scant regarding childhood scarring in areas where trachoma has been reduced to hypo-endemic levels. METHODS/PRINCIPLE FINDINGS: In this cross-sectional study, a random sample of children, ages 1-9 years, were selected from 38 communities in the formerly hyper-endemic district of Kongwa, Tanzania. Each participant received an ocular examination and eye-swab test for C. trachomatis infection. Conjunctival photographs were taken and analyzed at 5x magnification to determine scarring presence and severity. Community-level case clustering was assessed using intra-class correlation coefficients, and associations between TS presence and demographic/clinical factors were assessed using contingency table analyses. 1,496 children (78% of eligible) participated in this study. The mean age was 5.5 years and 51% were female. Scarring prevalence was 2.1% (95% CI: 1.5%- 3.0%). The prevalence of follicular trachoma and ocular C. trachomatis infection were 3.2% and 6.5%, respectively. Most TS cases (68.7%) fell into the mildest category, grade S1. 18.7% were grade S2; 12.6% were grade S3. No significant associations were seen between TS presence and age, sex, follicular trachoma, or active ocular C. trachomatis infection (p-values: 0.14, 0.48, 0.27, 0.15, respectively). Thirty communities (78.9%) had 0-1 TS cases, and the most seen in any single community was four cases. Three years ago, follicular trachoma prevalence averaged 4.9% in communities with 0-1 TS cases, but 7.6% in communities with 2-4 TS cases (p-value: 0.08). CONCLUSIONS: In this formerly hyper-endemic district of Tanzania, TS was rare in 1-9 year-olds and usually mild when present. Communities with higher rates of follicular trachoma in the past were more likely to have ≥2 cases of scarring, but the association was not statistically significant.
[Mh] Termos MeSH primário: Cicatriz/epidemiologia
Doenças Negligenciadas/epidemiologia
Tracoma
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Estudos Transversais
Feminino
Seres Humanos
Lactente
Masculino
Prevalência
Tanzânia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180111
[Lr] Data última revisão:
180111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006085


  8 / 1165 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29211746
[Au] Autor:Krentel A; Gyapong M; Mallya S; Boadu NY; Amuyunzu-Nyamongo M; Stephens M; McFarland DA
[Ad] Endereço:Bruyere Research Institute, Ottawa Canada.
[Ti] Título:Review of the factors influencing the motivation of community drug distributors towards the control and elimination of neglected tropical diseases (NTDs).
[So] Source:PLoS Negl Trop Dis;11(12):e0006065, 2017 Dec.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Community drug distributors or neglected tropical disease (NTD) volunteers have played a crucial role in ensuring the success of mass drug administration (MDA) programs using preventive chemotherapy (PC) for lymphatic filariasis, onchocerciasis, schistosomiasis, trachoma and soil transmitted helminths. In recent years however, a noticeable decline in motivation of some of these volunteers has been perceived, potentially negatively impacting the success of these programs. Potential hypotheses for this change in motivation include the long duration of many MDA programs, the change in sociocultural environments as well as the changes to the programs over time. This literature review identifies factors that affect NTD volunteer performance and motivation, which may be used to influence and improve future programming. METHODOLOGY/PRINCIPAL FINDINGS: A systematic search was conducted to identify studies published between January 1995 and September 2016 that investigate factors pertaining to volunteer motivation and performance in NTD drug distribution programs. Searches from several databases and grey literature yielded 400 records, of which 28 articles from 10 countries met the inclusion criteria. Quality assessment of studies was performed using the Critical Appraisal Skills Programme(CASP) checklist. Data pertaining to motivation, performance, retention and satisfaction was extracted and examined for themes. Recurring themes in the literature included monetary and material incentives, intrinsic motivation, gender, cost to participate, and health systems and community support. Of these, community support and the health system were found to be particularly impactful. Very few studies were found to explicitly look at novel incentives for volunteers and very few studies have considered the out of pocket and opportunity costs that NTD volunteers bear carrying out their tasks. CONCLUSIONS/SIGNIFICANCE: There is currently great interest in incorporating more attractive incentive schemes for NTD volunteers. However, our results show that the important challenges that volunteers face (cultural, health systems, financial and community related) may have less to do with financial incentives and may actually have a larger impact on their motivation than has previously been understood. Further integration of NTD programs into existing health systems is expected to improve the NTD volunteer working environment. Relevant community engagement related to the MDA program should also provide the supportive environment needed in the community to support NTD volunteers. Programs need to consider these issues to improve working conditions for NTD volunteers.
[Mh] Termos MeSH primário: Assistência à Saúde
Erradicação de Doenças/organização & administração
Motivação
Doenças Negligenciadas/prevenção & controle
Voluntários/psicologia
[Mh] Termos MeSH secundário: Assistência à Saúde/economia
Assistência à Saúde/recursos humanos
Assistência à Saúde/tendências
Erradicação de Doenças/economia
Erradicação de Doenças/métodos
Erradicação de Doenças/estatística & dados numéricos
Esquema de Medicação
Filariose Linfática/prevenção & controle
Seres Humanos
Esquistossomose/prevenção & controle
Tracoma/prevenção & controle
Medicina Tropical
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006065


  9 / 1165 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28470412
[Au] Autor:Zammarchi L; Vellere I; Stella L; Bartalesi F; Strohmeyer M; Bartoloni A
[Ad] Endereço:Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Largo Brambilla 3, 50134, Florence, Italy.
[Ti] Título:The diagnosis of neglected tropical diseases (NTDs) in Italy: reply.
[So] Source:Intern Emerg Med;12(5):725-726, 2017 08.
[Is] ISSN:1970-9366
[Cp] País de publicação:Italy
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças Negligenciadas
[Mh] Termos MeSH secundário: Seres Humanos
Itália
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1007/s11739-017-1672-2


  10 / 1165 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28448487
[Au] Autor:Hotez PJ; Damania A; Barua A; Stanaway J
[Ad] Endereço:Texas Children's Hospital Center for Vaccine Development, National School of Tropical Medicine at Baylor College of Medicine, Houston, Texas, United States of America.
[Ti] Título:The first "London Declaration": The Commonwealth and its neglected tropical diseases.
[So] Source:PLoS Negl Trop Dis;11(4):e0005321, 2017 Apr.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Saúde Global
Doenças Negligenciadas/epidemiologia
Doenças Negligenciadas/prevenção & controle
Medicina Tropical
[Mh] Termos MeSH secundário: Seres Humanos
Doenças Parasitárias/epidemiologia
Doenças Parasitárias/prevenção & controle
Tracoma/epidemiologia
Tracoma/prevenção & controle
Reino Unido
Viroses/epidemiologia
Viroses/prevenção & controle
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005321



página 1 de 117 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde