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Pesquisa : C23.550.414.838 [Categoria DeCS]
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  1 / 19603 MEDLINE  
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[PMID]:29441969
[Au] Autor:Lin S; Wu J; Guo W; Zhu Y
[Ti] Título:Effects of leonurine on intracerebral haemorrhage by attenuation of perihematomal edema and neuroinflammation the JNK pathway.
[So] Source:Pharmazie;71(11):644-650, 2016 11 02.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Perihematomal edema plays a critical role in secondary brain injury in intracerebral hemorrhage (ICH), which is associated with inflammation, hematoma toxicity and oxidative stress. In this work, we investigated the protective effects of leonurine, an alkaloid of Herbal Leonuri, and possible mechanisms to provide a basis for a new therapeutic approach for ICH treatment. In in vivo studies, we demonstrated for the first time that leonurine treatment substantially decreased perihematomal edema, ameliorated neurobehavioral function deficits, reduced apoptosis and protected injured cerebral tissue after ICH. These benefits appear to be ascribed to leonurine effectively attenuating bloodbrain barrier (BBB) breakdown in vivo, by inhibiting degradation of hemoglobin and alleviating inflammatory mediator release. In this study, BV-2 cells were exposed in vitro to oxyhemoglobin (OxyHb) at a concentration of 10 µM to mimic neuroinflammation after ICH. Consistent with the results of the in vivo study, leonurine significantly inhibited OxyHbinduced inflammatory proteins expression in BV-2 cells, mainly through inhibiting the c-Jun N-terminal kinase (JNK) signaling pathway. This is the first time that leonurine is proved to be capable to protect the injured cerebral tissue after ICH, based on alleviating neuroinflammation and attenuating BBB breakdown to ameliorate perihematomal edema.
[Mh] Termos MeSH primário: Edema Encefálico/tratamento farmacológico
Hemorragia Cerebral/tratamento farmacológico
Encefalite/tratamento farmacológico
Ácido Gálico/análogos & derivados
Hematoma/tratamento farmacológico
Proteínas Proto-Oncogênicas c-jun/efeitos dos fármacos
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/efeitos dos fármacos
Barreira Hematoencefálica/efeitos dos fármacos
Água Corporal/metabolismo
Edema Encefálico/patologia
Edema Encefálico/psicologia
Hemorragia Cerebral/psicologia
Encefalite/psicologia
Ácido Gálico/farmacologia
Hematoma/patologia
Hematoma/psicologia
Mediadores da Inflamação/metabolismo
Masculino
Metaloproteinase 9 da Matriz/metabolismo
Oxiemoglobinas/metabolismo
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Inflammation Mediators); 0 (Oxyhemoglobins); 0 (Proto-Oncogene Proteins c-jun); 09Q5W34QDA (leonurine); 632XD903SP (Gallic Acid); EC 3.4.24.35 (Matrix Metalloproteinase 9); EC 3.4.24.35 (Mmp9 protein, rat)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.6692


  2 / 19603 MEDLINE  
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[PMID]:29252755
[Au] Autor:Wiske CP; Itoga NK; Ullery BW; Hunt KJ; Chandra V
[Ad] Endereço:Warren Alpert Medical School, Brown University, Providence, Rhode Island.
[Ti] Título:Ruptured Pseudoaneurysm of the Dorsalis Pedis Artery Following Ankle Arthroscopy: A Case Report.
[So] Source:JBJS Case Connect;6(4):e102, 2016 Oct-Dec.
[Is] ISSN:2160-3251
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CASE: We describe the case of a pseudoaneurysm of the dorsalis pedis artery that developed following a repeat ankle arthroscopy for persistent osseous impingement. The patient underwent attempted fluid aspiration for a presumed effusion, and ultimately experienced rupture of the pseudoaneurysm with substantial blood loss, which required emergency vascular repair. CONCLUSION: Anterior tibial artery and dorsalis pedis artery pseudoaneurysms are relatively rare, but they are well-documented complications of ankle arthroscopy; however, their clinical importance is poorly understood. To our knowledge, this is the first reported case of a ruptured pseudoaneurysm of the dorsalis pedis artery following ankle surgery, and it highlights the need for timely diagnosis.
[Mh] Termos MeSH primário: Falso Aneurisma/etiologia
Aneurisma Roto/etiologia
Articulação do Tornozelo/cirurgia
Artroscopia/efeitos adversos
Complicações Pós-Operatórias/etiologia
[Mh] Termos MeSH secundário: Falso Aneurisma/cirurgia
Aneurisma Roto/cirurgia
Articulação do Tornozelo/irrigação sanguínea
Articulação do Tornozelo/diagnóstico por imagem
Hematoma/etiologia
Hematoma/cirurgia
Seres Humanos
Masculino
Meia-Idade
Complicações Pós-Operatórias/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.2106/JBJS.CC.16.00069


  3 / 19603 MEDLINE  
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[PMID]:29252645
[Au] Autor:Slaughter JB; Pulos N; Lim DP; Bozentka DJ
[Ad] Endereço:Departments of Orthopaedic Surgery (J.B.S., N.P., D.P.L., and D.J.B.) and Hand Surgery (D.J.B.), University of Pennsylvania, Philadelphia, Pennsylvania.
[Ti] Título:Hematoma of the Flexor Tendon Sheath Mimicking Acute Septic Tenosynovitis: A Case Report.
[So] Source:JBJS Case Connect;6(3):e68, 2016 Jul-Sep.
[Is] ISSN:2160-3251
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CASE: We report a case of a 65-year-old woman receiving chronic anticoagulation who presented with acute onset of severe long finger pain and was supratherapeutic on Coumadin. Her examination was consistent with early septic flexor tenosynovitis. She was treated with antibiotics and tendon sheath incision and drainage. Intraoperatively, she was found to have a hematoma in the flexor tendon sheath with no purulence. Her symptoms resolved with decompression. After 2 months, she had regained full range of motion with no deficits. CONCLUSION: Flexor tendon sheath hematoma warrants consideration in the differential diagnosis of patients presenting with the signs and symptoms of acute septic flexor tenosynovitis.
[Mh] Termos MeSH primário: Traumatismos da Mão/diagnóstico
Hematoma/diagnóstico
Tenossinovite/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Diagnóstico Diferencial
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.2106/JBJS.CC.15.00257


  4 / 19603 MEDLINE  
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[PMID]:29419699
[Au] Autor:Peng CH; Hsu CH; Wang NL; Lee HC; Lin SP; Chan WT; Yeung CY; Jiang CB
[Ad] Endereço:Department of Pediatric Gastroenterology, Hepatology and Nutrition.
[Ti] Título:Spontaneous retroperitoneal hemorrhage in Menkes disease: A rare case report.
[So] Source:Medicine (Baltimore);97(6):e9869, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Menkes disease (MD), also known as Menkes kinky hair disease, is a fatal neurodegenerative disease caused by a defect in copper metabolism. The symptoms involve multiple organ systems, such as the brain, lung, gastrointestinal tract, urinary tract, connective tissue, and skin. There is currently no cure for this disease entity, and patients with the classic form of MD usually die from complications between 6 months and 3 years of age. Intracranial hemorrhage secondary to tortuous intracranial arteries is a well-known complication of MD, but spontaneous retroperitoneal hemorrhage, to the best of our knowledge, has never been reported in a patient with MD. Herein, we describe the first case of retroperitoneal hematoma as a complication of MD in a 4-year-old boy. PATIENT CONCERNS: A 4-year-old Taiwanese male patient with MD was referred to the hospital and presented with a palpable epigastric mass. DIAGNOSES: On the basis of the findings of ultrasonography and enhanced computed tomography, the diagnosis was retroperitoneal hematoma. INTERVENTIONS: Interventions included laparotomy with evacuation of the hematoma, manual compression, and suture of the bleeding vessels. OUTCOMES: There were no postoperative complications. LESSONS: This case emphasizes that bleeding in patients with MD is possible at any site in the body owing to the unstable structure of the connective tissues. Timely diagnosis with proper imaging studies can lead to prompt and appropriate management and save patients from this life-threatening condition.
[Mh] Termos MeSH primário: Hematoma
Hemostasia Cirúrgica/métodos
Síndrome dos Cabelos Torcidos/complicações
Espaço Retroperitoneal/diagnóstico por imagem
[Mh] Termos MeSH secundário: Pré-Escolar
Hematoma/diagnóstico
Hematoma/etiologia
Seres Humanos
Laparotomia/métodos
Masculino
Tomografia Computadorizada por Raios X/métodos
Resultado do Tratamento
Ultrassonografia/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009869


  5 / 19603 MEDLINE  
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[PMID]:29320623
[Au] Autor:Kulic A; Cvetkovic Z; Libek V
[Ti] Título:Primary hyperfibrinolysis as the presenting sign of prostate cancer: A case report.
[So] Source:Vojnosanit Pregl;73(9):877-80, 2016 Sep.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Introduction: A bleeding syndrome in the setting of primary hyperfibrinolysis in a prostate cancer patient is only 0.40­ 1.65% of cases. The laboratory diagnosis of primary hyperfibrinolysis is based on the increase of biomarkers like D-dimer, fibrinogen split products, plasminogen, and euglobulin lysis test. These tests are not specific for primary hyperfibrinolysis. We reported a rare case of hemorrhagic syndrome caused by primary hyperfibrinolysis as the first clinical symptom of metastatic prostate cancer. Case report: A 64-year-old male was admitted to our hospital with large hematomas in the right pectoral and axillary areas (20 x 7 cm), right hemiabdomen (30 x 30 cm) and the left lumbal area, (25 x 5 cm). The patient had no subjective symptoms nor used any medication. Initial coagulation testing, prothrombin time (PT), and activated partial thromboplastin time (APTT) were within the normal range, while fibrinogen level was extremely low (1.068 g/L) (normal range 2.0­5.0) and the D-dimer assay result was high 1.122 mg/L (normal range < 0.23). The results obtained by rotation thrombelastometry pointed to primary fibrinolysis. Further clinical and laboratory examination indicated progressive malignant prostate disease. First line treatment for the patient was a combined administration of tranexamic acid (3 x 500 mg iv) and transfusion of ten units of cryoprecipitate (400 mL). Next day, fibrinolytic function measurements by rotation thrombelastometry were within the normal ranges. Fibrinogen level was normalized within two days (2.4 g/L). There were no newly developed hematomas. Conclusion: This case report shows primary hyperfibrinolysis with bleeding symptoms, which is an uncommon paraneoplastic phenomenon within expanded prostate malignancy. Rotation thrombelastometry in this severe complication helped to achieve the prompt and proper diagnosis and treatment.
[Mh] Termos MeSH primário: Adenocarcinoma/complicações
Transtornos da Coagulação Sanguínea/etiologia
Fibrinólise
Síndromes Paraneoplásicas/etiologia
Neoplasias da Próstata/complicações
[Mh] Termos MeSH secundário: Adenocarcinoma/sangue
Adenocarcinoma/secundário
Adenocarcinoma/terapia
Antifibrinolíticos/uso terapêutico
Biomarcadores/sangue
Transtornos da Coagulação Sanguínea/sangue
Transtornos da Coagulação Sanguínea/diagnóstico
Transtornos da Coagulação Sanguínea/tratamento farmacológico
Testes de Coagulação Sanguínea
Neoplasias Ósseas/secundário
Fator VIII/uso terapêutico
Fibrinogênio/uso terapêutico
Fibrinólise/efeitos dos fármacos
Hematoma/etiologia
Hemorragia/etiologia
Seres Humanos
Masculino
Meia-Idade
Síndromes Paraneoplásicas/sangue
Síndromes Paraneoplásicas/diagnóstico
Síndromes Paraneoplásicas/tratamento farmacológico
Neoplasias da Próstata/sangue
Neoplasias da Próstata/patologia
Neoplasias da Próstata/terapia
Ácido Tranexâmico/uso terapêutico
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifibrinolytic Agents); 0 (Biomarkers); 0 (cryoprecipitate coagulum); 6T84R30KC1 (Tranexamic Acid); 9001-27-8 (Factor VIII); 9001-32-5 (Fibrinogen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150525076K


  6 / 19603 MEDLINE  
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[PMID]:29172343
[Au] Autor:Malamos D; Scully C
[Ti] Título:Clinical Challenges Q&A 29. Black eye.
[So] Source:Dent Update;44(3):264, 2017 Mar.
[Is] ISSN:0305-5000
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Pálpebras/lesões
Hematoma/etiologia
Maus-Tratos Conjugais
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Maus-Tratos Conjugais/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  7 / 19603 MEDLINE  
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[PMID]:28449426
[Au] Autor:Ryu DG; Choi CW; Kang DH; Kim HW; Jeong DI; Kim WC; Shin JG; Lim TW
[Ad] Endereço:Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
[Ti] Título:[A Case of Intramural Hematoma of the Esophagus Mimicking Acute Coronary Syndrome].
[So] Source:Korean J Gastroenterol;69(4):239-242, 2017 Apr 25.
[Is] ISSN:2233-6869
[Cp] País de publicação:Korea (South)
[La] Idioma:kor
[Ab] Resumo:Intramural hematoma of the esophagus is a rare condition that can be spontaneous or secondary to trauma, toxic ingestion, or intervention. If it is the spontaneous type, it usually presents initially with epigastric pain, hematemesis or dysphagia. We present a case of intramural hematoma of the esophagus mimicking acute coronary syndrome. A 63-year-old man presented with severe acute chest pain. He has four coronary stents that were inserted five years ago, from a different hospital, and is on dual antiplatelet agents. Coronary angiography was performed immediately under the suspicion of acute coronary syndrome, and we found that there was no obvious clogging of the coronary arteries. Next, chest computed tomography was performed due to suspected aortic dissection, and the result was also negative. Four days later, endoscopy was performed and intramural hematoma covered with large ulcers was diagnosed.
[Mh] Termos MeSH primário: Doenças do Esôfago/diagnóstico
Hematoma/diagnóstico
[Mh] Termos MeSH secundário: Síndrome Coronariana Aguda/diagnóstico
Diagnóstico Diferencial
Endoscopia Gastrointestinal
Doenças do Esôfago/tratamento farmacológico
Esôfago/patologia
Hematoma/tratamento farmacológico
Seres Humanos
Masculino
Meia-Idade
Inibidores da Agregação de Plaquetas/uso terapêutico
Ticlopidina/análogos & derivados
Ticlopidina/uso terapêutico
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS
[Nm] Nome de substância:
0 (Platelet Aggregation Inhibitors); A74586SNO7 (clopidogrel); OM90ZUW7M1 (Ticlopidine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.4166/kjg.2017.69.4.239


  8 / 19603 MEDLINE  
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[PMID]:29172372
[Au] Autor:Calderon-Miranda W; Villa-Mejia E; Moscote-Salazar LR; Escobar N
[Ti] Título:Síndrome de Wünderlich Secundario a Fistula Arteriovenosa Postraumática: Reporte de caso..
[So] Source:Bol Asoc Med P R;108(2):85-7, 2016.
[Is] ISSN:0004-4849
[Cp] País de publicação:Puerto Rico
[La] Idioma:spa
[Mh] Termos MeSH primário: Fístula Arteriovenosa/complicações
Hematoma/diagnóstico por imagem
Hemorragia/diagnóstico por imagem
Nefropatias/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Fístula Arteriovenosa/etiologia
Hematoma/etiologia
Hemorragia/etiologia
Seres Humanos
Nefropatias/etiologia
Masculino
Síndrome
Ferimentos e Lesões/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171214
[Lr] Data última revisão:
171214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  9 / 19603 MEDLINE  
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[PMID]:27772672
[Au] Autor:Lewandowski A; Dorsey S
[Ad] Endereço:Case Western Reserve University, MetroHealth Medical Center, and the Cleveland Clinic Emergency Medicine Residency Program, Cleveland, OH.
[Ti] Título:Young Man With Severe Abdominal Pain.
[So] Source:Ann Emerg Med;68(5):544-552, 2016 Nov.
[Is] ISSN:1097-6760
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Dor Abdominal/etiologia
Hematoma/complicações
Hematoma/diagnóstico por imagem
Nefropatias/complicações
Nefropatias/diagnóstico por imagem
[Mh] Termos MeSH secundário: Dor Abdominal/diagnóstico por imagem
Adulto
Hematoma/terapia
Seres Humanos
Nefropatias/terapia
Masculino
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  10 / 19603 MEDLINE  
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[PMID]:29069046
[Au] Autor:Cai Q; Zhang H; Zhao D; Yang Z; Hu K; Wang L; Zhang W; Chen Z; Chen Q
[Ad] Endereço:aDepartment of Neurosurgery, Renmin Hospital of Wuhan University, Hubei Province bDepartments of Neurosurgery, PLA General Hospital, Beijing cDepartments of Neurosurgery, the Second Clinical Medical College, Yangtze University, Hubei Province dDepartment of Radiology, Renmin Hospital of Wuhan University, Hubei province eDepartment of Neurosurgery, Central Hospital of Xiangyang City, Hubei Province, China.
[Ti] Título:Analysis of three surgical treatments for spontaneous supratentorial intracerebral hemorrhage.
[So] Source:Medicine (Baltimore);96(43):e8435, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This retrospective study aimed to evaluate the effectiveness and safety of 3 surgical procedures for Spontaneous Supratentorial Intracerebral Hemorrhage (SICH).A total of 63 patients with SICH were randomized into 3 groups. Group A (n = 21) underwent craniotomy surgery, group B (n = 22) underwent burr hole, urokinase infusion and catheter drainage, and group C (n = 20) underwent neuroendoscopic surgery. The hematoma evacuation rate of the operation was analyzed by 3D Slice software and the average surgery time, visualization during operation, decompressive effect, mortality, Glasgow Coma Scale (GCS) improvement, complications include rebleeding, pneumonia, intracranial infection were also compared among 3 groups.All procedures were successfully completed and the hematoma evacuation rate was significant differences among 3 groups which were 79.8%, 43.1%, 89.3% respectively (P < .01), and group C was the highest group. Group B was smallest traumatic one and shared the shortest operation time, but for the lack of hemostasis, it also the highest rebleeding group (P = .03). Although there were different in complications, but there was no significant in pneumonia, intracranial infection, GCS improvement and mortality rate.All these 3 methods had its own advantages and shortcomings, and every approach had its indications for SICH. Although for neuroendoscopic technical's minimal invasive, direct vision, effectively hematoma evacuation rate, and the relatively optimistic result, it might be a more promising approach for SICH.
[Mh] Termos MeSH primário: Hemorragia Cerebral/cirurgia
Craniotomia/métodos
Drenagem/métodos
Hematoma/cirurgia
Neuroendoscopia/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Hemorragia Cerebral/mortalidade
Craniotomia/efeitos adversos
Drenagem/efeitos adversos
Feminino
Escala de Coma de Glasgow
Hematoma/mortalidade
Seres Humanos
Masculino
Meia-Idade
Neuroendoscopia/efeitos adversos
Duração da Cirurgia
Distribuição Aleatória
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008435



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