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  1 / 1946 MEDLINE  
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[PMID]:29366780
[Au] Autor:Lin YC; Wang FS; Yang YL; Chuang YT; Huang YH
[Ad] Endereço:Department of Pediatrics, Chiayi Chang Gung Memorial Hospital, Taiwan.
[Ti] Título:MicroRNA-29a mitigation of toll-like receptor 2 and 4 signaling and alleviation of obstructive jaundice-induced fibrosis in mice.
[So] Source:Biochem Biophys Res Commun;496(3):880-886, 2018 02 12.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cholestasis and hepatitis can cause continuous liver damage that may ultimately result in liver fibrosis. In a previous study, we demonstrated that microRNA-29a (miR-29a) protects against liver fibrosis. Toll-like receptor 2 (TLR2) and TLR4 are pattern recognition receptors of bacterial lipoprotein and lipopolysaccharide, both of which participate in activating hepatic stellate cells and liver fibrosis. The purpose of this study is to characterize the biological influence of miR-29a on TLR2 and TLR4 signaling in livers injured with bile duct ligation (BDL). We performed BDL on both miR-29a transgenic mice (miR-29aTg) and wild-type mice to induce cholestatic liver injury. Primary HSCs were transfected with a miR-29a mimic and inhibitor. In the wild-type mice, the BDL demonstrated significant α-smooth muscle actin fibrotic matrix formation and hepatic high mobility group box-1 expression. However, in the miR-29aTg mice, these factors were significantly reduced. Furthermore, miR-29a overexpression reduced the BDL exaggeration of TLR2, TLR4, MyD88, bromodomain-containing protein 4 (BRD4), phospho-p65 as well as proinflammatory cytokines, IL-1ß, MCP-1, TGF-ß, and TNF-α. In vitro, miR-29a mimic transfection reduced α-SMA, BRD4,TLR2, and TLR4 expressions in HSCs. This study provides new molecular insight into the ability of miR-29a to inhibit TLR2 and TLR4 signaling, which thus slows the progression of cholestatic liver deterioration.
[Mh] Termos MeSH primário: Icterícia Obstrutiva/metabolismo
Cirrose Hepática Biliar/metabolismo
MicroRNAs/metabolismo
Receptor 2 Toll-Like/metabolismo
Receptor 4 Toll-Like/metabolismo
[Mh] Termos MeSH secundário: Animais
Citocinas/metabolismo
Icterícia Obstrutiva/complicações
Icterícia Obstrutiva/patologia
Cirrose Hepática Biliar/complicações
Cirrose Hepática Biliar/patologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cytokines); 0 (MIRN29 microRNA, mouse); 0 (MicroRNAs); 0 (Tlr2 protein, mouse); 0 (Tlr4 protein, mouse); 0 (Toll-Like Receptor 2); 0 (Toll-Like Receptor 4)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE


  2 / 1946 MEDLINE  
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[PMID]:29275776
[Au] Autor:Al-Zahir MZ; AlAmeel T
[Ad] Endereço:Department of Medicine, King Fahad Specialist Hospital-Dammam, Dammam, Saudi Arabia.
[Ti] Título:Extrahepatic cholangiocarcinoma with prolonged survival: a case report.
[So] Source:J Med Case Rep;11(1):357, 2017 Dec 25.
[Is] ISSN:1752-1947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cholangiocarcinoma has poor prognosis and short term-survival. Here, we report the case of a patient with unusually prolonged survival. CASE PRESENTATION: Our patient was a 56-year-old Arab man with a 6-month history of obstructive jaundice. A computed tomography scan of his abdomen revealed a mass at the confluence of the hepatic ducts with suspected malignant strictures on endoscopy. A positive tissue diagnosis was achieved more than 18 months after commencement of his symptoms. He remained functional throughout this period despite recurrent episodes of cholangitis. CONCLUSIONS: Cholangiocarcinoma is a presumably fatal disease, especially because patients tend to present late with unresectable disease. Many patient-related and disease-related factors may alter survival.
[Mh] Termos MeSH primário: Neoplasias dos Ductos Biliares/diagnóstico por imagem
Ductos Biliares Extra-Hepáticos/diagnóstico por imagem
Tumor de Klatskin/diagnóstico por imagem
[Mh] Termos MeSH secundário: Neoplasias dos Ductos Biliares/complicações
Neoplasias dos Ductos Biliares/patologia
Ductos Biliares Extra-Hepáticos/patologia
Colangiocarcinoma/complicações
Colangiocarcinoma/diagnóstico por imagem
Colangiocarcinoma/patologia
Colangiopancreatografia Retrógrada Endoscópica
Colangite/etiologia
Seres Humanos
Icterícia Obstrutiva/etiologia
Tumor de Klatskin/complicações
Tumor de Klatskin/patologia
Masculino
Meia-Idade
Taxa de Sobrevida
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171226
[St] Status:MEDLINE
[do] DOI:10.1186/s13256-017-1519-5


  3 / 1946 MEDLINE  
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[PMID]:29245333
[Au] Autor:Ji H; Yue F; Song J; Zhou X
[Ad] Endereço:aDepartment of Pharmacy, Affiliated Yancheng Hospital of Southeast University Medical CollegebDepartment of Pharmacy, Sir Runrun Hospital, Nanjing Medical UniversitycDepartment of Hepatobiliary Surgery, Affiliated Yancheng Hospital of Southeast University Medical College, Jiangsu, China.
[Ti] Título:A rare case of methimazole-induced cholestatic jaundice in an elderly man of Asian ethnicity with hyperthyroidism: A case report.
[So] Source:Medicine (Baltimore);96(49):e9093, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Methimazole is an antithyroid drug that is widely used for the treatment of hyperthyroidism. As an inhibitor of the enzyme thyroperoxidase, methimazole is generally well-tolerated. However, there have been increasing reports of methimazole-induced liver damage, although this effect of methimazole has been limited by the absence of objective diagnosis of the liver condition or the inappropriate use of the Naranjo scale. We present the case of an elderly man with hyperthyroidism, gastritis, and epilepsy who developed liver damage after administration of multiple drugs. KEY POINTS FROM THE CASE: Considering the low sensitivity of the Naranjo scale in detecting rare reactions associated with liver damage, we used the Roussel-Uclaf Causality Assessment Method scale, with a finding of cholestatic jaundice hepatitis induced by methimazole. The patient's liver enzyme levels improved after discontinuation of methimazole. MAIN LESSONS LEARNED: Our case underlines the possible hepatoxicity associated with the use of methimazole. A review of the literature confirmed a selective hepatoxicity risk in individuals of Asian ethnicity, which has not been identified in Caucasian or Black populations. Physicians should be aware of the risk of hepatoxicity when prescribing oral methimazole to patients of Asian ethnicity.
[Mh] Termos MeSH primário: Antitireóideos/efeitos adversos
Doença Hepática Induzida por Substâncias e Drogas/etiologia
Icterícia Obstrutiva/induzido quimicamente
Metimazol/efeitos adversos
[Mh] Termos MeSH secundário: Idoso
Antitireóideos/uso terapêutico
Grupo com Ancestrais do Continente Asiático
Seres Humanos
Hipertireoidismo/tratamento farmacológico
Testes de Função Hepática
Masculino
Metimazol/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antithyroid Agents); 554Z48XN5E (Methimazole)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009093


  4 / 1946 MEDLINE  
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[PMID]:29224663
[Au] Autor:O'Connell W; Shah J; Mitchell J; Prologo JD; Martin L; Miller MJ; Martin JG
[Ad] Endereço:Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA. Electronic address: william.o'connell@emoryhealthcare.org.
[Ti] Título:Obstruction of the Biliary and Urinary System.
[So] Source:Tech Vasc Interv Radiol;20(4):288-293, 2017 Dec.
[Is] ISSN:1557-9808
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Biliary and urinary obstructions can be managed endoscopically or cystoscopically, surgically or by percutansous intervention or drainage. If the obtructed system is infected, emergent decompression is needed. Early recognition and treatment is paramount in both conditions. Acute cholangitis can present many different ways, from mild symptoms to fulminant sepsis. It is usually a result of ascending bacterial colonization and biliary obstruction resulting in bacterial overgrowth. Therefore, those patients with recent biliary instrumentation or previous biliary modification are at higher risk. Charcot's triad of fever, right upper quadrant abdominal pain, and jaundice is only seen in 50%-70% of patients. Fever is seen in over 90% of cases, pain is seen in 70% of cases, and jaundice is seen in 60% of cases. Altered mental status and hypotension are associated with severe cases. All 5 symptoms of fever, right upper quadrant abdominal pain, jaundice, altered mental status, and hypotension are referred to as Reynold's Pentad. Acute pyonephrosis can also present many different ways, from minimal symptoms to fulminant sepsis. Fever, chills, and flank pain are the classic symptoms, although some patients may be relatively asymptomatic. Pyonephrosis may present with a classic triad of fever, flank pain, and hydronephrosis, or simply hydronephrosis and sepsis. Pyonephrosis usually occurs as a result of urinary obstruction with either an ascending infection of the urinary tract or hematogenous spread of a bacterial pathogen as the culprit. Up to 75% of cases are related to urinary stone disease. Patients are at increased risk for pyonephrosis when they haven anatomic urinary tract obstruction, certain chronic diseases (diabetes meliitus and AIDS), or are immunosuppressed due to immunodeficiency or medications, (chronic steroid therapy).
[Mh] Termos MeSH primário: Colangite/terapia
Colestase/terapia
Drenagem/métodos
Procedimentos Endovasculares/métodos
Icterícia Obstrutiva/terapia
Cálculos Renais/terapia
Nefrostomia Percutânea/métodos
Radiografia Intervencionista
Obstrução Ureteral/terapia
[Mh] Termos MeSH secundário: Adolescente
Idoso de 80 Anos ou mais
Angiografia
Colangite/diagnóstico por imagem
Colangite/etiologia
Colangite/fisiopatologia
Colestase/diagnóstico por imagem
Colestase/etiologia
Colestase/fisiopatologia
Drenagem/efeitos adversos
Procedimentos Endovasculares/efeitos adversos
Feminino
Seres Humanos
Icterícia Obstrutiva/diagnóstico por imagem
Icterícia Obstrutiva/etiologia
Icterícia Obstrutiva/fisiopatologia
Cálculos Renais/diagnóstico por imagem
Cálculos Renais/etiologia
Cálculos Renais/fisiopatologia
Masculino
Nefrostomia Percutânea/efeitos adversos
Fatores de Risco
Resultado do Tratamento
Ultrassonografia
Obstrução Ureteral/diagnóstico por imagem
Obstrução Ureteral/etiologia
Obstrução Ureteral/fisiopatologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


  5 / 1946 MEDLINE  
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[PMID]:29258066
[Au] Autor:Imai H; Takenaka M; Omoto S; Kamata K; Miyata T; Minaga K; Yamao K; Sakurai T; Nishida N; Watanabe T; Kitano M; Kudo M
[Ad] Endereço:Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.
[Ti] Título:Utility of Endoscopic Ultrasound-Guided Hepaticogastrostomy with Antegrade Stenting for Malignant Biliary Obstruction after Failed Endoscopic Retrograde Cholangiopancreatography.
[So] Source:Oncology;93 Suppl 1:69-75, 2017.
[Is] ISSN:1423-0232
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Endoscopic ultrasound (EUS)-guided biliary drainage (BD) is a well-recognized alternative BD method after unsuccessful endoscopic transpapillary drainage. EUS-guided hepaticogastrostomy (HGS) with antegrade stenting (AGS) was recently applied to the treatment of malignant obstructive jaundice. OBJECTIVE: To assess the efficacy and safety of HGS combined with AGS for treatment of malignant biliary stricture-induced obstructive jaundice. DESIGN: Retrospective cohort study. SETTING: Single academic tertiary care center. PATIENTS: From January 2006 to December 2014, endoscopic retrograde cholangiopancreatography was attempted in patients with obstructive jaundice; it was successful in 641 patients and impossible in 154 patients (postsurgically altered anatomy or duodenal stenosis, n = 101; difficult cannulation, n = 53). In total, 145 patients underwent EUS-guided BD; HGS and HGS with AGS were attempted in 42 patients (Group A, January 2006-August 2011) and 37 patients (Group B, September 2011-December 2014), respectively. INTERVENTIONS: Under EUS and fluoroscopy guidance, HGS and HGS with AGS were performed via needle puncture, guidewire insertion, puncture-hole dilation, and stent placement. MAIN OUTCOME MEASUREMENTS: Groups A and B were compared in terms of technical success, functional success, adverse event rates, re-intervention rates, patient survival time, and time to stent dysfunction or patient death. The two groups were also compared in a subgroup analysis of only 28 patients who underwent chemotherapy. RESULTS: The technical success rate was significantly higher in Group A than B (97.6 vs. 83.8%, p = 0.03). The functional success rate was comparable between the two groups (90.2 vs. 90.3%), although the rate of adverse events was significantly higher in Group A than B (26.1 vs. 10.8%, p = 0.03). The re-intervention rate tended to be higher in Group A than B (16.7 vs. 8.1%, p = 0.25). Groups A and B did not differ significantly in terms of median overall patient survival (75 vs. 61 days, p = 0.70) or median time to stent dysfunction or patient death (68 vs. 63 days, p = 0.08). Among patients who underwent chemotherapy, there was no difference in overall patient survival time between the two groups (121 vs. 157 days, p = 0.08), although time to stent dysfunction or patient death was significantly shorter in Group A than B (71 vs. 95 days, p = 0.02). CONCLUSION: Although the technical success rate of HGS with AGS was lower than that of HGS, HGS with AGS was superior to HGS in terms of adverse event rate and stent patency in patients receiving chemotherapy.
[Mh] Termos MeSH primário: Neoplasias dos Ductos Biliares/cirurgia
Colestase/cirurgia
Icterícia Obstrutiva/cirurgia
Stents
[Mh] Termos MeSH secundário: Idoso
Neoplasias dos Ductos Biliares/patologia
Colangiopancreatografia Retrógrada Endoscópica
Colestase/patologia
Estudos de Coortes
Drenagem/métodos
Feminino
Seres Humanos
Icterícia Obstrutiva/patologia
Masculino
Estudos Retrospectivos
Ultrassonografia de Intervenção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171221
[Lr] Data última revisão:
171221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.1159/000481233


  6 / 1946 MEDLINE  
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[PMID]:29191277
[Au] Autor:Iskandar ME; Wayne MG; Steele JG; Cooperman AM
[Ad] Endereço:Department of Surgery, Mount Sinai Beth Israel, 10 Union Square East, Suite 2M, New York, NY 10003, USA. Electronic address: mazenelia.iskandar@mountsinai.org.
[Ti] Título:A Tale of 2 Techniques: Preoperative Biliary Drainage and Routine Surgical Drainage with Pancreaticoduodenectomy.
[So] Source:Surg Clin North Am;98(1):49-55, 2018 Feb.
[Is] ISSN:1558-3171
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Preoperative drainage of an obstructed biliary tree before pancreaticoduodenal resection (PDR) and placement of intraabdominal drains following pancreatic resection have been suggested to be both unnecessary and associated with a higher complication rate. The evidence for and against that practice is presented and analyzed to highlight its risks and benefits. A selective approach on an individual basis for preoperative biliary decompression is advocated, based on multiple factors. Additionally, the evidence for routine use of surgical drains after PDR is critically reviewed and the rationale for routine drainage is made.
[Mh] Termos MeSH primário: Ducto Colédoco/cirurgia
Drenagem/métodos
Icterícia Obstrutiva
Neoplasias Pancreáticas
Pancreaticoduodenectomia/métodos
Cuidados Pré-Operatórios/métodos
Stents
[Mh] Termos MeSH secundário: Colangiopancreatografia Retrógrada Endoscópica
Ducto Colédoco/diagnóstico por imagem
Seres Humanos
Icterícia Obstrutiva/diagnóstico
Icterícia Obstrutiva/etiologia
Icterícia Obstrutiva/cirurgia
Neoplasias Pancreáticas/complicações
Neoplasias Pancreáticas/diagnóstico
Neoplasias Pancreáticas/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE


  7 / 1946 MEDLINE  
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[PMID]:29191276
[Au] Autor:Gholami S; Brennan MF
[Ad] Endereço:Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, C-1272, New York, NY 10065, USA.
[Ti] Título:Preoperative Stenting for Benign and Malignant Periampullary Diseases: Unnecessary if Not Harmful.
[So] Source:Surg Clin North Am;98(1):37-47, 2018 Feb.
[Is] ISSN:1558-3171
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Preoperative biliary drainage (PBD) is often performed in patients with jaundice with the presumption that it will decrease the risk of postoperative complications. PBD carries its own risk of complications and, therefore, has been controversial. Multiple randomized controlled trials and metaanalyses have shown that PBD has significantly increased overall complications compared with surgery alone. As such, the routine application of PBD should be avoided except in a subset of clinical situations. This is discussed in detail in this article.
[Mh] Termos MeSH primário: Colangiopancreatografia Retrógrada Endoscópica/métodos
Neoplasias do Ducto Colédoco
Icterícia Obstrutiva/cirurgia
Pancreaticoduodenectomia
Cuidados Pré-Operatórios/métodos
Stents
Procedimentos Desnecessários
[Mh] Termos MeSH secundário: Ducto Colédoco/diagnóstico por imagem
Ducto Colédoco/cirurgia
Neoplasias do Ducto Colédoco/complicações
Neoplasias do Ducto Colédoco/diagnóstico
Neoplasias do Ducto Colédoco/cirurgia
Drenagem/métodos
Seres Humanos
Icterícia Obstrutiva/diagnóstico
Icterícia Obstrutiva/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE


  8 / 1946 MEDLINE  
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[PMID]:28739769
[Au] Autor:Tang K; Sui LL; Xu G; Zhang T; Liu Q; Liu XF
[Ad] Endereço:Department of Hepatobiliary Surgery, Affiliated Yantai Yuhuangding Hospital, Qingdao University Medical College, Yantai, P.R. China.
[Ti] Título:Effects of Different Palliative Jaundice Reducing Methods on Immunologic Functions in Patients with Advanced Malignant Obstructive Jaundice.
[So] Source:Anticancer Res;37(8):4665-4670, 2017 08.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: This study aimed to investigate the effects of three treatment methods on the immunological function of patients with advanced malignant obstructive jaundice (MOJ). PATIENTS AND METHODS: Patients with advanced MOJ were randomly divided into three groups according to biliary drainage methods. Detection of levels of multi-indices were investigated in different time periods. RESULTS: After drainage, the levels of complement 3 (C3) and complement 4 (C4) were increased. Forteen days post-operation, the levels of immunoglobulin G (IgG), immunoglobulin A (IgA) and immunoglobulin M (IgM) in the group undergoing palliative surgery decreased significantly compared to those in both percutaneous transhepatic cholangio drainage (PTCD) and endoscopic retrograde biliary drainage (ERBD) groups. The level of serum endotoxin in the group undergoing palliative surgery decreased gradually. CONCLUSION: Palliative surgery for reducing jaundice is superior to PTCD and ERBD in improving immune function of patients with MOJ.
[Mh] Termos MeSH primário: Imunidade
Icterícia Obstrutiva/etiologia
Icterícia Obstrutiva/terapia
Neoplasias/complicações
Cuidados Paliativos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Bilirrubina/sangue
Complemento C3/imunologia
Complemento C4/imunologia
Drenagem/métodos
Endotoxinas/sangue
Feminino
Seres Humanos
Isotipos de Imunoglobulinas/sangue
Isotipos de Imunoglobulinas/imunologia
Icterícia Obstrutiva/diagnóstico
Masculino
Meia-Idade
Imagem Multimodal
Neoplasias/diagnóstico
Cuidados Paliativos/métodos
Estudos Retrospectivos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Complement C3); 0 (Complement C4); 0 (Endotoxins); 0 (Immunoglobulin Isotypes); RFM9X3LJ49 (Bilirubin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


  9 / 1946 MEDLINE  
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[PMID]:28739766
[Au] Autor:Wang T; Liu S; Zheng YB; Song XP; Sun BL; Jiang WJ; Wang LG
[Ad] Endereço:Department of Interventional Therapy, Yuhuangding Hospital, Yantai, P.R. China.
[Ti] Título:Clinical Study on Using I Seeds Articles Combined with Biliary Stent Implantation in the Treatment of Malignant Obstructive Jaundice.
[So] Source:Anticancer Res;37(8):4649-4653, 2017 08.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Mh] Termos MeSH primário: Braquiterapia
Radioisótopos do Iodo
Icterícia Obstrutiva/etiologia
Icterícia Obstrutiva/terapia
Stents
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Procedimentos Cirúrgicos do Sistema Biliar
Biomarcadores Tumorais
Terapia Combinada
Feminino
Seguimentos
Seres Humanos
Icterícia Obstrutiva/mortalidade
Estimativa de Kaplan-Meier
Masculino
Meia-Idade
Cuidados Pós-Operatórios
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Iodine Radioisotopes)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


  10 / 1946 MEDLINE  
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[PMID]:28628014
[Au] Autor:Bykov M; Sepiashvili R; Shchava V; Gobayeva S; Bykov I; Basov A
[Ad] Endereço:1Kuban state medical university, Krasnodar, Russia; 2Scientific research institute of the Ochapovsky regional clinic of the ministry of Public health of Russia, Krasnodar, Russia; 3Peopels Friendship University of Russia,(RUDN University), Moscow, Russia.
[Ti] Título:[SELECTION OF MINI-INVASIVE PALLIATIVE DECOMPRESSION METHOD IN PATIENTS WITH MALIGNANT OBSTRUCTION OF BILIARY DUCTS BASED ON THE STUDY OF BIOCHEMICAL BILE INDEXES].
[So] Source:Georgian Med News;(266):47-54, 2017 May.
[Is] ISSN:1512-0112
[Cp] País de publicação:Georgia (Republic)
[La] Idioma:rus
[Ab] Resumo:The article gives our own experience in the determination and study of additional laboratory criteria (total lipids, cholesterol, maximum and area chemiluminescence, antioxidant activity) at the local level (in bile) in patients with bile duct obstruction of malignant etiology. Constellation of metabolic disorders allowed to propose an original method for determining the lithogenicity of bile (integral indicator of lithogenicity). The obtained data made it possible to justify the need to assess the degree of metabolic disturbances in bile, on the basis of which it is possible to predict the risk of lithogenesis and the duration of stent operation, which in turn helped optimize the algorithm for choosing the method of bile ducts decompression aimed at preventing early obturation of endoprostheses.
[Mh] Termos MeSH primário: Neoplasias do Sistema Biliar/complicações
Colestase/cirurgia
Descompressão Cirúrgica
Neoplasias Pancreáticas/complicações
Stents
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Colestase/etiologia
Seres Humanos
Icterícia Obstrutiva/etiologia
Icterícia Obstrutiva/cirurgia
Procedimentos Cirúrgicos Minimamente Invasivos
Cuidados Paliativos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE



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