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  1 / 3155 MEDLINE  
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[PMID]:29367530
[Au] Autor:Nariai R; Kobayashi T; Masuda H; Ono H; Imadome KI; Kubota M; Ito S; Ishiguro A
[Ad] Endereço:National Center for Child Health and Development, Department of Postgraduate Education and Training.
[Ti] Título:[Transient detection of lupus anticoagulant in acute phase of Kawasaki disease].
[So] Source:Nihon Rinsho Meneki Gakkai Kaishi;40(6):456-459, 2017.
[Is] ISSN:1349-7413
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:  In Kawasaki disease (KD), endothelial damage and an elevation in coagulant factors provoke thrombosis. Lupus anticoagulant (LA) is strongly associated with the risk of thrombosis in patients with antiphospholipid syndrome; however, there has been no report of positive LA in KD patients. A previously healthy, 2-year-old boy was admitted due to fever, bilateral conjunctivitis, redness of the lips, and unilateral cervical lymphadenopathy. Typical Kawasaki disease was diagnosed on day 5 of illness. Adenovirus antigens were detected in his stool. After the KD symptoms were successfully treated with intravenous immunoglobulin, his activated partial thromboplastin time (APTT) increased to 88 seconds at eight days of illness. The cross-mixing test showed an inhibition pattern, and the presence of LA was proved using diluted Russell's viper venom time. APPT elongation improved due to continued low dose aspirin therapy without thromboembolisms. The possibility of contamination by LA was low because six other patients treated with the same immunoglobulin lot showed no APTT elongation. We speculated that KD-related infections led to the presence of LA, which may have triggered the thrombosis. Further accumulation of data is warranted to elucidate the role of LA in KD patients.
[Mh] Termos MeSH primário: Reação de Fase Aguda/sangue
Reação de Fase Aguda/diagnóstico
Inibidor de Coagulação do Lúpus/sangue
Síndrome de Linfonodos Mucocutâneos/sangue
Síndrome de Linfonodos Mucocutâneos/diagnóstico
[Mh] Termos MeSH secundário: Reação de Fase Aguda/tratamento farmacológico
Aspirina/administração & dosagem
Pré-Escolar
Seres Humanos
Imunoglobulinas Intravenosas/administração & dosagem
Masculino
Síndrome de Linfonodos Mucocutâneos/complicações
Síndrome de Linfonodos Mucocutâneos/tratamento farmacológico
Tempo de Tromboplastina Parcial
Trombose/etiologia
Trombose/prevenção & controle
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulins, Intravenous); 0 (Lupus Coagulation Inhibitor); R16CO5Y76E (Aspirin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.2177/jsci.40.456


  2 / 3155 MEDLINE  
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[PMID]:29254303
[Au] Autor:Abbasi MH; Fatima S; Khawar MB; Naz N; Mujeeb KA; Akhtar T; Sheikh N
[Ad] Endereço:Department of Zoology, Government College of Science, Lahore, Pakistan.
[Ti] Título:Dose-dependent acute phase response of aqueous leaf decoction of Nerium oleander in Wistar rats.
[So] Source:J Biol Regul Homeost Agents;31(4):985-989, 2017 Oct-Dec.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Many studies have been carried out in order to determine the toxicity of medicinal plants. The objective of this study was to compare and analyze the hepatic response against two doses of Nerium oleander, (N. oleander) “kaner” leaf decoction. Aqueous leaf decoction was injected intramuscularly into both hind limbs of male rats (200∓10g), assigned into three categories (n=4): control group with no treatment; group I, injected with 5 ml/ kg; and group II injected with 10 ml/ kg of leaf decoction, respectively. Animals were sacrificed 6 h after administration and hepato-histological changes were then observed. The decoction induced an acute phase reaction reflected by a more significant recruitment of inflammatory cells in group II than in group I and controls, as observed by histological studies. These results indicated that both doses can induce an acute-phase condition. Hence, traditional practice of medicinal plants without preliminary dose assessment must not be administered.
[Mh] Termos MeSH primário: Reação de Fase Aguda/induzido quimicamente
Fígado/efeitos dos fármacos
Nerium/química
Extratos Vegetais/efeitos adversos
Folhas de Planta/química
[Mh] Termos MeSH secundário: Reação de Fase Aguda/imunologia
Reação de Fase Aguda/patologia
Animais
Biomarcadores/metabolismo
Relação Dose-Resposta Imunológica
Ectodisplasinas/imunologia
Ectodisplasinas/metabolismo
Imuno-Histoquímica
Injeções Intramusculares
Fígado/imunologia
Fígado/patologia
Masculino
Plantas Medicinais
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Ectodysplasins); 0 (Plant Extracts)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


  3 / 3155 MEDLINE  
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[PMID]:29183523
[Au] Autor:Kim S; McClave SA; Martindale RG; Miller KR; Hurt RT
[Ti] Título:Hypoalbuminemia and Clinical Outcomes: What is the Mechanism behind the Relationship?
[So] Source:Am Surg;83(11):1220-1227, 2017 Nov 01.
[Is] ISSN:1555-9823
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Albumin has a number of important physiologic functions, which include maintaining oncotic pressure, transporting various agents (fatty acids, bile acids, cholesterol, metal ions, and drugs), scavenging free oxygen radicals, acting as an antioxidant, and exerting an antiplatelet effect. Hypoalbuminemia in adults, defined by an intravascular albumin level of <3.5 g/dL, is associated with poor postoperative outcomes in patients undergoing surgical intervention. Although the relationship of hypoalbuminemia and poor surgical outcome has been known for many years, the pathophysiology behind the relationship is unclear. Three theoretical constructs might explain this relationship. First, albumin might serve as a nutritional marker, such that hypoalbuminemia represents poor nutritional status in patients who go on to experience poor postoperative outcomes. Second, albumin has its own pharmacologic characteristics as an antioxidant or transporter, and therefore, the lack of albumin might result in a deficiency of those functions, resulting in poor postoperative outcomes. Or third, albumin is known to be a negative acute phase protein, and as such hypoalbuminemia might represent an increased inflammatory status of the patient, potentially leading to poor outcomes. A thorough review of the literature reveals the fallacy of these arguments and fails to show a direct cause and effect between low albumin levels per se and adverse outcomes. Interventions designed solely to correct preoperative hypoalbuminemia, in particular intravenous albumin infusion, do little to change the patient's course of hospitalization. While surgeons may use albumin levels on admission for their prognostic value, they should avoid therapeutic strategies whose main endpoint is correction of this abnormality.
[Mh] Termos MeSH primário: Hipoalbuminemia/etiologia
Complicações Pós-Operatórias/etiologia
Albumina Sérica/administração & dosagem
[Mh] Termos MeSH secundário: Reação de Fase Aguda/diagnóstico
Reação de Fase Aguda/etiologia
Biomarcadores/análise
Seres Humanos
Inflamação/diagnóstico
Infusões Intravenosas
Desnutrição/etiologia
Estado Nutricional
Albumina Sérica/análise
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Serum Albumin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171204
[Lr] Data última revisão:
171204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE


  4 / 3155 MEDLINE  
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[PMID]:28615263
[Au] Autor:Merrill RD; Burke RM; Northrop-Clewes CA; Rayco-Solon P; Flores-Ayala R; Namaste SM; Serdula MK; Suchdev PS
[Ad] Endereço:Nutrition Branch, CDC, Atlanta, GA; rdaymerrill@cdc.gov psuchde@emory.edu.
[Ti] Título:Factors associated with inflammation in preschool children and women of reproductive age: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project.
[So] Source:Am J Clin Nutr;106(Suppl 1):348S-358S, 2017 Jul.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In many settings, populations experience recurrent exposure to inflammatory agents that catalyze fluctuations in the concentrations of acute-phase proteins and certain micronutrient biomarkers such as C-reactive protein (CRP), α-1-acid glycoprotein (AGP), ferritin, and retinol. Few data are available on the prevalence and predictors of inflammation in diverse settings. We aimed to assess the relation between inflammation (CRP concentration >5 mg/L or AGP concentration >1 g/L) and covariates, such as demographics, reported illness, and anthropometric status, in preschool children (PSC) (age range: 6-59 mo) and women of reproductive age (WRA) (age range: 15-49 y). Cross-sectional data from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project from 29,765 PSC in 16 surveys and 25,731 WRA in 10 surveys were used to model bivariable and multivariable relations. The inflammation prevalence was 6.0-40.2% in PSC and 7.9-29.5% in WRA (elevated CRP) and 21.2-64.3% in PSC and 7.1-26.7% in WRA (elevated AGP). In PSC, inflammation was consistently positively associated with recent fever and malaria but not with other recent illnesses. In multivariable models that were adjusted for age, sex, urban or rural residence, and socioeconomic status, elevated AGP was positively associated with stunting (height-for-age score <-2) in 7 of 10 surveys. In WRA, elevated CRP was positively associated with obesity [body mass index (in kg/m ) ≥30] in 7 of 9 surveys. Other covariates showed inconsistent patterns of association with inflammation. In a pooled analysis of surveys that measured malaria, stunting was associated with elevated AGP but not CRP in PSC, and obesity was associated with both elevated CRP and AGP in WRA. Recent morbidity and abnormal anthropometric status are consistently associated with inflammation across a range of environments, whereas more commonly collected demographic covariates were not. Because of the challenge of defining a general demographic population or environmental profile that is more likely to experience inflammation, inflammatory markers should be measured in surveys to account for their effects.
[Mh] Termos MeSH primário: Anemia/diagnóstico
Biomarcadores/análise
Inflamação/diagnóstico
[Mh] Termos MeSH secundário: Reação de Fase Aguda
Adolescente
Adulto
Anemia Ferropriva/diagnóstico
Proteína C-Reativa/análise
Pré-Escolar
Estudos Transversais
Feminino
Ferritinas/análise
Seres Humanos
Lactente
Inflamação/epidemiologia
Meia-Idade
Estado Nutricional
Obesidade
Orosomucoide/análise
Vitamina A/análise
Deficiência de Vitamina A/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Orosomucoid); 11103-57-4 (Vitamin A); 9007-41-4 (C-Reactive Protein); 9007-73-2 (Ferritins)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.142315


  5 / 3155 MEDLINE  
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[PMID]:28570647
[Au] Autor:Bengtson S; Knudsen KB; Kyjovska ZO; Berthing T; Skaug V; Levin M; Koponen IK; Shivayogimath A; Booth TJ; Alonso B; Pesquera A; Zurutuza A; Thomsen BL; Troelsen JT; Jacobsen NR; Vogel U
[Ad] Endereço:National Research Centre for the Working Environment, Copenhagen Ø, Denmark.
[Ti] Título:Differences in inflammation and acute phase response but similar genotoxicity in mice following pulmonary exposure to graphene oxide and reduced graphene oxide.
[So] Source:PLoS One;12(6):e0178355, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We investigated toxicity of 2-3 layered >1 µm sized graphene oxide (GO) and reduced graphene oxide (rGO) in mice following single intratracheal exposure with respect to pulmonary inflammation, acute phase response (biomarker for risk of cardiovascular disease) and genotoxicity. In addition, we assessed exposure levels of particulate matter emitted during production of graphene in a clean room and in a normal industrial environment using chemical vapour deposition. Toxicity was evaluated at day 1, 3, 28 and 90 days (18, 54 and 162 µg/mouse), except for GO exposed mice at day 28 and 90 where only the lowest dose was evaluated. GO induced a strong acute inflammatory response together with a pulmonary (Serum-Amyloid A, Saa3) and hepatic (Saa1) acute phase response. rGO induced less acute, but a constant and prolonged inflammation up to day 90. Lung histopathology showed particle agglomerates at day 90 without signs of fibrosis. In addition, DNA damage in BAL cells was observed across time points and doses for both GO and rGO. In conclusion, pulmonary exposure to GO and rGO induced inflammation, acute phase response and genotoxicity but no fibrosis.
[Mh] Termos MeSH primário: Reação de Fase Aguda
Grafite/toxicidade
Inflamação/patologia
Pulmão/efeitos dos fármacos
Mutagênicos/toxicidade
[Mh] Termos MeSH secundário: Animais
Líquido da Lavagem Broncoalveolar
Feminino
Grafite/química
Camundongos
Camundongos Endogâmicos C57BL
Oxirredução
Óxidos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mutagens); 0 (Oxides); 7782-42-5 (Graphite)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178355


  6 / 3155 MEDLINE  
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[PMID]:28552869
[Au] Autor:Tokida H; Shiga Y; Shimoe Y; Yamori S; Tanaka A; Kuriyama M
[Ad] Endereço:Department of Rehabilitation, Brain Attack Center Ota Memorial Hospital.
[Ti] Título:Foreign accent syndrome caused by the left precentral infarction-a case report.
[So] Source:Rinsho Shinkeigaku;57(6):293-297, 2017 06 28.
[Is] ISSN:1882-0654
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A 57-year-old right-handed man was admitted to our hospital because of right facial paresis and acute-onset dysarthria. He presented with non-fluent aphasia. His aphasia gradually improved, but he started speaking with a strange accent and intonation from the fifth hospital day. He was diagnosed with foreign accent syndrome (FAS), which lasted for 2 months. MRI revealed ischemic infarction with edema in the superior, middle, and inferior parts of the left precentral gyrus. One year later, MRI revealed old, small infarct lesions in the left precentral gyrus, middle frontal gyrus, and postcentral gyrus. We suspected that FAS developed because of disturbance of prosody in the speaking network on improving his aphasia. His meticulous character was probably influenced on developing FAS. The responsible lesions possibly were those in the reversible parts of the left precentral gyrus with edema on acute stage.
[Mh] Termos MeSH primário: Transtornos da Articulação/etiologia
Infarto Cerebral/complicações
[Mh] Termos MeSH secundário: Reação de Fase Aguda
Afasia/etiologia
Infarto Cerebral/diagnóstico por imagem
Infarto Cerebral/patologia
Imagem de Difusão por Ressonância Magnética
Disartria/etiologia
Edema
Paralisia Facial/etiologia
Lobo Frontal/diagnóstico por imagem
Lobo Frontal/patologia
Seres Humanos
Masculino
Meia-Idade
Personalidade/fisiologia
Síndrome
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170530
[St] Status:MEDLINE
[do] DOI:10.5692/clinicalneurol.cn-000988


  7 / 3155 MEDLINE  
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[PMID]:28552256
[Au] Autor:Jouneau S; Dres M; Guerder A; Bele N; Bellocq A; Bernady A; Berne G; Bourdin A; Brinchault G; Burgel PR; Carlier N; Chabot F; Chavaillon JM; Cittee J; Claessens YE; Delclaux B; Deslée G; Ferré A; Gacouin A; Girault C; Ghasarossian C; Gouilly P; Gut-Gobert C; Gonzalez-Bermejo J; Jebrak G; Le Guillou F; Léveiller G; Lorenzo A; Mal H; Molinari N; Morel H; Morel V; Noel F; Pégliasco H; Perotin JM; Piquet J; Pontier S; Rabbat A; Revest M; Reychler G; Stelianides S; Surpas P; Tattevin P; Roche N
[Ad] Endereço:Groupe de travail des recommandations de la SPLF sur la prise en charge des exacerbations de BPCO, Société de pneumologie de langue française, 75006 Paris, France; IRSET UMR 1085, service de pneumologie, hôpital Pontchaillou, université de Rennes 1, CHU de Rennes, 35033 Rennes, France. Electronic ad
[Ti] Título:Management of acute exacerbations of chronic obstructive pulmonary disease (COPD). Guidelines from the Société de pneumologie de langue française (summary).
[So] Source:Rev Mal Respir;34(4):282-322, 2017 Apr.
[Is] ISSN:1776-2588
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Chronic obstructive pulmonary disease (COPD) is the chronic respiratory disease with the most important burden on public health in terms of morbidity, mortality and health costs. For patients, COPD is a major source of disability because of dyspnea, restriction in daily activities, exacerbation, risk of chronic respiratory failure and extra-respiratory systemic organ disorders. The previous French Language Respiratory Society (SPLF) guidelines on COPD exacerbations were published in 2003. Using the GRADE methodology, the present document reviews the current knowledge on COPD exacerbation through 4 specific outlines: (1) epidemiology, (2) clinical evaluation, (3) therapeutic management and (4) prevention. Specific aspects of outpatients and inpatients care are discussed, especially regarding assessment of exacerbation severity and pharmacological approach.
[Mh] Termos MeSH primário: Doença Pulmonar Obstrutiva Crônica/terapia
[Mh] Termos MeSH secundário: Reação de Fase Aguda
Progressão da Doença
França
Seres Humanos
Linguagem
Doença Pulmonar Obstrutiva Crônica/epidemiologia
Doença Pulmonar Obstrutiva Crônica/patologia
Qualidade de Vida
Índice de Gravidade de Doença
Sociedades Médicas/normas
Análise de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRACTICE GUIDELINE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170530
[St] Status:MEDLINE


  8 / 3155 MEDLINE  
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[PMID]:28506765
[Au] Autor:Dayoub R; Buerger L; Ibrahim S; Melter M; Weiss TS
[Ad] Endereço:University Children's Hospital Regensburg (KUNO), University Hospital Regensburg, Germany; Department of Biochemistry and Microbiology, Faculty of Pharmacy, Damascus University, Damascus, Syria. Electronic address: rania.dayoub@ukr.de.
[Ti] Título:Augmenter of liver regeneration (ALR) exhibits a dual signaling impact on hepatic acute-phase response.
[So] Source:Exp Mol Pathol;102(3):428-433, 2017 Jun.
[Is] ISSN:1096-0945
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The acute-phase response (APR) is an inflammatory process triggered mainly by IL-6 in response to neoplasm, tissue injury, infection or inflammation. Signaling of IL-6 is transduced by activating STAT3 which rapidly results in production of acute-phase proteins (APPs) such as fibrinogen ß (FGB) and haptoglobin (HP). Augmenter of liver regeneration (ALR), a hepatotrophic factor supporting liver regeneration, was reported to be upregulated after liver damage. In this study we analyzed the role of ALR for IL-6 signaling and APR. Thus, we investigated the expression and release of APPs in human liver cells under conditions of increased exogenous or endogenous ALR. HepG2 cells and ALR-reexpressing HepG2 cells were treated with IL-6 in the presence or absence of exogenous ALR for different time points. The mRNA expression and release of both FGB and HP were measured by RT-PCR and ELISA. We found that exogenously applied ALR attenuated the IL-6-induced mRNA expression and protein secretion of both FGB and HP. In contrast, IL-6 stimulation in HepG2 cells which re-express ALR, revealed elevated APR shown by increased mRNA expression and secretion of FGB and HP. Furthermore, we found that ALR-mediated regulation of IL-6-induced APP production is accompanied by altered STAT3 activity. While exogenous ALR reduced the IL-6-induced phosphorylation of STAT3, endogenous ALR enhanced STAT3 activity in liver cells. In conclusion, ALR, dependent on its localization, changes APR at least in part, by modifying STAT3 activation. This study shows a dual signaling of ALR and suggests that ALR is pivotal for the regulation of APR, a crucial event in liver injury and regeneration.
[Mh] Termos MeSH primário: Reação de Fase Aguda/genética
Redutases do Citocromo/metabolismo
Hepatócitos/metabolismo
Fator de Transcrição STAT3/metabolismo
[Mh] Termos MeSH secundário: Reação de Fase Aguda/patologia
Redutases do Citocromo/genética
Fibrinogênio/genética
Fibrinogênio/metabolismo
Haptoglobinas/genética
Haptoglobinas/metabolismo
Células Hep G2
Seres Humanos
Interleucina-6/farmacologia
Fígado/metabolismo
Regeneração Hepática
Chaperonas Moleculares/genética
Chaperonas Moleculares/metabolismo
Fosforilação
Proteínas Inibidoras de STAT Ativados/genética
Proteínas Inibidoras de STAT Ativados/metabolismo
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Fator de Transcrição STAT3/genética
Transdução de Sinais
Proteína 3 Supressora da Sinalização de Citocinas/genética
Proteína 3 Supressora da Sinalização de Citocinas/metabolismo
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Haptoglobins); 0 (Interleukin-6); 0 (Molecular Chaperones); 0 (PIAS3 protein, human); 0 (Protein Inhibitors of Activated STAT); 0 (RNA, Messenger); 0 (SOCS3 protein, human); 0 (STAT3 Transcription Factor); 0 (STAT3 protein, human); 0 (Suppressor of Cytokine Signaling 3 Protein); 9001-32-5 (Fibrinogen); EC 1.6.2.- (Cytochrome Reductases); EC 1.6.2.- (GFER protein, human)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE


  9 / 3155 MEDLINE  
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[PMID]:28502961
[Au] Autor:Koami H; Sakamoto Y; Miyasho T; Noguchi R; Sato N; Kai K; Chris Yamada K; Inoue S
[Ad] Endereço:Department of Emergency and Critical Care Medicine, Faculty of Medicine, Saga University.
[Ti] Título:Haptoglobin Reduces Inflammatory Cytokine INF-γ and Facilitates Clot Formation in Acute Severe Burn Rat Model.
[So] Source:J Nippon Med Sch;84(2):64-72, 2017.
[Is] ISSN:1347-3409
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Haptoglobin exerts renal protective function by scavenging free hemoglobin from the urine and blood stream in patients with hemolytic disorders. Recent studies elucidate the relationships between haptoglobin and inflammation. In addition, coagulopathy is often induced by systemic inflammation characterized by the presence of vascular endothelial damage. We hypothesize that haptoglobin might have an anti-inflammatory effect and affect hypercoagulability using rat burn model. Thirty anesthetized rats of six-weeks of age received over 30% full-thickness scald burn on the dorsal skin surface. All rats were injected with either haptoglobin (Hpt) or normal saline (NS) intraperitoneally. The rats were divided into three groups: 1) control group (NS 20 mL/kg); 2) low concentration of Hpt group, L-Hpt, (Hpt 4 mL (80 U) /kg+NS 16 mL/kg); and 3) high concentration of Hpt group, H-Hpt, (Hpt 20 mL (400 U) /kg). While under anesthesia, all rats were euthanized by exsanguination at 6 hours (N=5) and 24 hours (N=5). Inflammatory and anti-inflammatory cytokines were measured and whole-blood viscoelastic tests were performed by thromboelastometry (ROTEM). Haptoglobin significantly reduced free hemoglobin 24 hours after the injury. Improvement of hematuria was confirmed in the H-Hpt group. There were no differences in thrombin-antithrombin complex and plasmin-α2 plasmin inhibitor complex. The haptoglobin tended to decrease interferon-gamma (IFN-γ) in H-Hpt group. ROTEM findings of the L-Hpt group showed significantly higher clot firmness and shorter time to maximum clot formation velocity than the control group. Haptoglobin reduced INF-γ, and accelerated speed of clot formation in acute phase of severe burn.
[Mh] Termos MeSH primário: Reação de Fase Aguda/sangue
Reação de Fase Aguda/metabolismo
Anti-Inflamatórios
Coagulação Sanguínea
Queimaduras/sangue
Queimaduras/metabolismo
Haptoglobinas/farmacologia
Mediadores da Inflamação/sangue
Interferon gama/sangue
[Mh] Termos MeSH secundário: Animais
Coagulação Sanguínea/efeitos dos fármacos
Modelos Animais de Doenças
Haptoglobinas/uso terapêutico
Hematúria/tratamento farmacológico
Hemoglobinas/metabolismo
Masculino
Ratos Sprague-Dawley
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Haptoglobins); 0 (Hemoglobins); 0 (Inflammation Mediators); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE
[do] DOI:10.1272/jnms.84.64


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[PMID]:28433610
[Au] Autor:Camps J; Iftimie S; García-Heredia A; Castro A; Joven J
[Ad] Endereço:Unitat de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, C. Sant Joan, s/n, 43201 Reus, Catalonia, Spain. Electronic address: jcamps@grupsagessa.com.
[Ti] Título:Paraoxonases and infectious diseases.
[So] Source:Clin Biochem;50(13-14):804-811, 2017 Sep.
[Is] ISSN:1873-2933
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The paraoxonases (PON1, PON2 and PON3) are an enzyme family with a high structural homology. All of them have lactonase activity and degrade lipid peroxides in lipoproteins and cells. As such, they play a role in protection against oxidation and inflammation. Infectious diseases are often associated with oxidative stress and an inflammatory response. Infection and inflammation trigger a cascade of reactions in the host, known as the acute-phase response. This response is associated with dramatic changes in serum proteins and lipoproteins, including a decrease in serum PON1 activity. These alterations have clinical consequences for the infected patient, including an increased risk for cardiovascular diseases, and an impaired protection against the formation of antibiotic-resistant bacterial biofilms. Several studies have investigated the value of serum PON1 measurement as a biomarker of the infection process. Low serum PON1 activities are associated with poor survival in patients with severe sepsis. In addition, preliminary studies suggest that serum PON1 concentration and/or enzyme activity may be useful as markers of acute concomitant infection in patients with an indwelling central venous catheter. Investigating the associations between paraoxonases and infectious diseases is a recent, and productive, line of research.
[Mh] Termos MeSH primário: Arildialquilfosfatase/metabolismo
Doenças Transmissíveis/enzimologia
Imunidade Inata
Modelos Biológicos
Estresse Oxidativo
[Mh] Termos MeSH secundário: Reação de Fase Aguda/sangue
Reação de Fase Aguda/enzimologia
Reação de Fase Aguda/imunologia
Reação de Fase Aguda/microbiologia
Animais
Arildialquilfosfatase/sangue
Arildialquilfosfatase/química
Arildialquilfosfatase/genética
Biomarcadores/sangue
Cateteres de Demora/efeitos adversos
Cateteres de Demora/microbiologia
Cateteres Venosos Centrais/efeitos adversos
Cateteres Venosos Centrais/microbiologia
Doenças Transmissíveis/sangue
Doenças Transmissíveis/imunologia
Doenças Transmissíveis/microbiologia
Infecção Hospitalar/sangue
Infecção Hospitalar/enzimologia
Infecção Hospitalar/imunologia
Infecção Hospitalar/microbiologia
Seres Humanos
Polimorfismo Genético
Regiões Promotoras Genéticas
Sepse/sangue
Sepse/enzimologia
Sepse/imunologia
Sepse/microbiologia
Homologia Estrutural de Proteína
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); EC 3.1.8.1 (Aryldialkylphosphatase); EC 3.1.8.1 (PON1 protein, human); EC 3.1.8.1 (PON2 protein, human); EC 3.1.8.1 (PON3 protein, human)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170424
[St] Status:MEDLINE



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