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[PMID]:28463157
[Au] Autor:Schaefer IM; Hornick JL; Barysauskas CM; Raut CP; Patel SA; Royce TJ; Fletcher CDM; Baldini EH
[Ad] Endereço:Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
[Ti] Título:Histologic Appearance After Preoperative Radiation Therapy for Soft Tissue Sarcoma: Assessment of the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group Response Score.
[So] Source:Int J Radiat Oncol Biol Phys;98(2):375-383, 2017 06 01.
[Is] ISSN:1879-355X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To critically assess the prognostic value of the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (EORTC-STBSG) response score and define histologic appearance after preoperative radiation therapy (RT) for soft tissue sarcoma (STS). METHODS AND MATERIALS: For a cohort of 100 patients with STS of the extremity/trunk treated at our institution with preoperative RT followed by resection, 2 expert sarcoma pathologists evaluated the resected specimens for percent residual viable cells, necrosis, hyalinization/fibrosis, and infarction. The EORTC response score and other predictors of recurrence-free survival (RFS) and overall survival (OS) were assessed by Kaplan-Meier and proportional hazard models. RESULTS: Median tumor size was 7.5 cm; 92% were intermediate or high grade. Most common histologies were unclassified sarcoma (34%) and myxofibrosarcoma (25%). Median follow-up was 60 months. The 5-year local recurrence rate was 5%, 5-year RFS was 68%, and 5-year OS was 75%. Distribution of cases according to EORTC response score tiers was as follows: no residual viable tumor for 9 cases (9% pathologic complete response); <1% viable tumor for 0, ≥1% to <10% for 9, ≥10% to <50% for 44, and ≥50% for 38. There was no association between EORTC-STBSG response score and RFS or OS. Conversely, hyalinization/fibrosis was a significant independent favorable predictor for RFS (hazard ratio 0.49, P=.007) and OS (hazard ratio 0.36, P=.02). CONCLUSION: Histologic evaluation after preoperative RT for STS showed a 9% pathologic complete response rate. The EORTC-STBSG response score and percent viable cells were not prognostic. Hyalinization/fibrosis was associated with favorable outcome, and if validated, may become a valid endpoint for neoadjuvant trials.
[Mh] Termos MeSH primário: Sarcoma/patologia
Sarcoma/radioterapia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Sobrevivência Celular
Intervalo Livre de Doença
Feminino
Fibrossarcoma/mortalidade
Fibrossarcoma/patologia
Fibrossarcoma/radioterapia
Fibrossarcoma/cirurgia
Fibrose/patologia
Seguimentos
Seres Humanos
Infarto/patologia
Estimativa de Kaplan-Meier
Leiomiossarcoma/mortalidade
Leiomiossarcoma/patologia
Leiomiossarcoma/radioterapia
Leiomiossarcoma/cirurgia
Lipossarcoma/mortalidade
Lipossarcoma/patologia
Lipossarcoma/radioterapia
Lipossarcoma/cirurgia
Masculino
Meia-Idade
Necrose/patologia
Neoplasia Residual
Modelos de Riscos Proporcionais
Sarcoma/mortalidade
Sarcoma/cirurgia
Fatores de Tempo
Resultado do Tratamento
Carga Tumoral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:28747159
[Au] Autor:Spaltenstein M; Humbert F; Vu DL; Uçkay I; John G
[Ad] Endereço:Division of Internal Medicine, Hôpital Neuchâtelois, La Chaux-de-Fonds, Switzerland.
[Ti] Título:A case report of CT-diagnosed renal infarct secondary to syphilitic aortitis.
[So] Source:BMC Infect Dis;17(1):520, 2017 07 26.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Even though reported cases of syphilis have been increasing, cases of tertiary syphilis remain extremely rare. The majority of our knowledge with regard to complications of syphilis such as aortitis was acquired before the advent of relatively modern technologies such as CT, MRI and PET. This case report presents a rare case of syphilitic aortitis associated with a renal infarct caused by a peripheral arterial embolism diagnosed by CT. CASE PRESENTATION: We present a young man with sudden abdominal pain and flank tenderness without fever. Blood tests showed acute kidney failure. Computed tomography showed a right renal infarct and a non-circular thickening of the descending thoracic aortic wall with intra-luminal thrombus. Serology confirmed the diagnosis of syphilis. Treatment with anticoagulant and penicillin resulted in a good outcome. Follow-up PET-MRI showed resolution of the thrombus with a metabolically inactive atheromatous plaque. CONCLUSION: Technologies, such as CT, PET-CT and PET-MRI, that were not present during the pre-antibiotic era, can provide new insights into rare presentations of tertiary syphilis such as aortitis. These imaging modalities show promise for early radiological diagnosis of aortitis in syphilis and may be useful for determining the response to treatment in specific cases.
[Mh] Termos MeSH primário: Aortite/diagnóstico por imagem
Aortite/microbiologia
Infarto/diagnóstico por imagem
Sífilis Cardiovascular/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Antibacterianos/uso terapêutico
Aortite/tratamento farmacológico
Seres Humanos
Infarto/tratamento farmacológico
Infarto/microbiologia
Rim/irrigação sanguínea
Rim/diagnóstico por imagem
Imagem por Ressonância Magnética
Masculino
Penicilinas/uso terapêutico
Tomografia por Emissão de Pósitrons
Sífilis/diagnóstico por imagem
Sífilis/tratamento farmacológico
Sífilis Cardiovascular/tratamento farmacológico
Sífilis Cardiovascular/patologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Penicillins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180120
[Lr] Data última revisão:
180120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2624-1


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[PMID]:29310334
[Au] Autor:Sun N; Lu G; Zhang L; Wang X; Gao C; Bi J; Wang X
[Ti] Título:Clinical efficacy of spleen-preserving distal pancreatectomy with or without splenic vessel preservation: A Meta-analysis.
[So] Source:Medicine (Baltimore);96(48):e8600, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The meta-analysis was performed to investigate the clinical efficacy of spleen-preserving distal pancreatectomy with splenic vessel preservation (SPDP-SVP) and spleen-preserving distal pancreatectomy with splenic vessel resection (SPDP-SVR). METHODS: Potential articles were searched on the databases of Pubmed, Embase, and Chinese National Knowledge Infrastructure (CNKI) from January 1988 until March 2017. Weight mean difference (WMD) with 95% confidence interval (CI) was applied to compare the efficacy of SPDP-SVP and SPDP-SVR. Odds ratio (OR) with 95% CI was calculated to figure out the risks for complications. P< .05 or I>50% indicated significant heterogeneity. The random-effects model is used to pool data if significant heterogeneity exists; otherwise, the fixed-effects model is used. Publication bias was evaluated by Begg's funnel plot. RESULTS: Thirteen eligible articles were obtained in the meta-analysis. SPDP-SVP seemed to relate with reduced operative time and blood loss, prolonged hospital stay, and less complications; however, the effects were not statistically significant. Meanwhile, we found that SPDP-SVP was closely related with the reduced rate of splenic infarction and gastric varices (OR = 0.16, 95% CI = 0.09-0.29; OR = 0.08, 95% CI = 0.02-0.35). No publication bias was observed in the analysis (P = .636). CONCLUSIONS: SPDP-SVP seems to show superiority than SPDP-SVR in reducing the rate of splenic infarction and gastric varices.
[Mh] Termos MeSH primário: Pancreatectomia/métodos
Baço/irrigação sanguínea
Baço/cirurgia
[Mh] Termos MeSH secundário: Perda Sanguínea Cirúrgica/estatística & dados numéricos
Seres Humanos
Infarto/epidemiologia
Tempo de Internação/estatística & dados numéricos
Duração da Cirurgia
Complicações Pós-Operatórias/epidemiologia
Varizes/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008600


  4 / 6302 MEDLINE  
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[PMID]:28810043
[Au] Autor:Garrity ST; Holz EJ; Sarraf D
[Ti] Título:Amalric Triangular Syndrome Associated With Outer Nuclear Layer Infarction.
[So] Source:Ophthalmic Surg Lasers Imaging Retina;48(8):668-670, 2017 Aug 01.
[Is] ISSN:2325-8179
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An 85-year-old man presented with temporal headache and bilateral paracentral scotomas. Clinical examination, laboratory testing, and temporal artery biopsy confirmed the diagnosis of giant cell arteritis. Fluorescein angiography illustrated Amalric triangular choroidal infarction of the left eye. Spectral-domain optical coherence tomography of the left eye demonstrated outer nuclear layer abnormalities adjacent to the choroidal infarct. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:668-670.].
[Mh] Termos MeSH primário: Doenças da Coroide/complicações
Corioide/irrigação sanguínea
Infarto/complicações
Escotoma/etiologia
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Doenças da Coroide/diagnóstico
Angiofluoresceinografia/métodos
Seguimentos
Fundo de Olho
Seres Humanos
Infarto/diagnóstico
Masculino
Escotoma/diagnóstico
Síndrome
Tomografia de Coerência Óptica/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE
[do] DOI:10.3928/23258160-20170802-10


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[PMID]:28784056
[Au] Autor:Vitiello GA; Blumberg SN; Sadek M
[Ad] Endereço:1 Division of Vascular and Endovascular Surgery, New York University Langone Medical Center, NY, USA.
[Ti] Título:Endovascular Treatment of Spontaneous Renal Artery Dissection After Failure of Medical Management.
[So] Source:Vasc Endovascular Surg;51(7):509-512, 2017 Oct.
[Is] ISSN:1938-9116
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Spontaneous renal artery dissection (SRAD) is a rare disease with approximately 200 cases reported in the literature. The severity of renal compromise, the anatomic location of the dissection, and the presence of uncontrollable hypertension are used to guide the initial management of SRAD. However, there are no reported guidelines for managing the progression of SRAD after acute failure of medical management. In this case, a 40-year-old man with a recently diagnosed SRAD was managed appropriately with therapeutic anticoagulation, yet presented with progression of his dissection and a new acute renal infarct. A covered endovascular stent was used to successfully control dissection progression and prevent further renal compromise.
[Mh] Termos MeSH primário: Aneurisma Dissecante/terapia
Anticoagulantes/uso terapêutico
Procedimentos Endovasculares
Infarto/terapia
Artéria Renal
[Mh] Termos MeSH secundário: Adulto
Aneurisma Dissecante/diagnóstico por imagem
Angiografia por Tomografia Computadorizada
Progressão da Doença
Seres Humanos
Infarto/diagnóstico por imagem
Masculino
Artéria Renal/diagnóstico por imagem
Tomografia Computadorizada Espiral
Falha de Tratamento
Ultrassonografia Doppler em Cores
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticoagulants)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE
[do] DOI:10.1177/1538574417723155


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[PMID]:28692549
[Au] Autor:Ciraci S; Ozcan A; Ozdemir MM; Chiang SCC; Tesi B; Ozdemir AM; Karakukcu M; Patiroglu T; Acipayam C; Doganay S; Gumus H; Unal E
[Ad] Endereço:Departments of *Radiology, Division of Pediatric Radiology †Pediatrics, Division of Pediatric Hematology Oncology ∥Pediatrics, Division of Pediatric Neurology, Faculty of Medicine, Erciyes University, Kayseri §Department of Pediatrics, Division of Pediatric Hematology & Oncology, Sutcu Imam University, Kahramanmaras, Turkey ‡Department of Medicine, Karolinska Institutet, Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.
[Ti] Título:A Case of Familial Hemophagocytic Lymphohistiocytosis Type 4 With Involvement of the Central Nervous System Complicated With Infarct.
[So] Source:J Pediatr Hematol Oncol;39(6):e321-e324, 2017 Aug.
[Is] ISSN:1536-3678
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Familial hemophagocytic lymphohistiocytosis (HLH) is a fatal disease affecting infants and very young children. Central nervous system involvement of HLH can cause catastrophic results. METHOD: We present a case with cranial involvement of familial HLH type 4 who showed diffuse infiltration of white matter complicated with intracranial thrombosis. A 5-year-old girl from a consanguineous couple presented with fever and pancytopenia, and was referred to our hematology unit. Examination revealed fever, lymphadenopathy, and hepatosplenomegaly. Ultrasound examination revealed hepatosplenomegaly and free intra-abdominal fluid. HLH was revealed on bone marrow aspiration biopsy. Defective natural killer and T lymphocyte cytotoxicity using degranulation tests was determined. In the genetic analysis, syntaxin gene mutation was found. On T2-weighted and T2-fluid-attenuated inversion recovery magnetic resonance imaging (MRI), diffuse hyperintense signal changes of cerebral white matter, indicating white matter demyelination, were observed. A second brain MRI showed an acute infarct involving the left temporooccipital region. Immunosuppressive therapy according to the HLH 2004 protocol was started. The infarct resolved but white matter lesions were stable on the brain MRI that was performed 1 month later. Brain MRI taken 4 months after the first examination showed stable cerebral white matter lesions, but hyperintense signal changes appeared in the cerebellar white matter and were regarded as progression. The patient died because of infection despite immunosuppressive therapy. CONCLUSIONS: Physicians managing patients with HLH must be vigilant about the possibility of central nervous system involvement including stroke.
[Mh] Termos MeSH primário: Doenças do Sistema Nervoso Central/complicações
Infarto/etiologia
Linfo-Histiocitose Hemofagocítica/patologia
[Mh] Termos MeSH secundário: Pré-Escolar
Progressão da Doença
Evolução Fatal
Feminino
Seres Humanos
Trombose Intracraniana/etiologia
Leucoencefalopatias/etiologia
Leucoencefalopatias/patologia
Linfo-Histiocitose Hemofagocítica/complicações
Imagem por Ressonância Magnética/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170711
[St] Status:MEDLINE
[do] DOI:10.1097/MPH.0000000000000886


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[PMID]:28670166
[Au] Autor:Park SE; Choi DS; Shin HS; Baek HJ; Choi HC; Kim JE; Choi HY; Park MJ
[Ad] Endereço:Department of Radiology, Gyeongsang National University School of Medicine, Jinju 52727, Korea.
[Ti] Título:Splenial Lesions of the Corpus Callosum: Disease Spectrum and MRI Findings.
[So] Source:Korean J Radiol;18(4):710-721, 2017 Jul-Aug.
[Is] ISSN:2005-8330
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:The corpus callosum (CC) is the largest white matter structure in the brain, consisting of more than 200-250 million axons that provide a large connection mainly between homologous cerebral cortical areas in mirror image sites. The posterior end of the CC is the thickest part, which is called the splenium. Various diseases including congenital to acquired lesions including congenital anomalies, traumatic lesions, ischemic diseases, tumors, metabolic, toxic, degenerative, and demyelinating diseases, can involve the splenium of the CC and their clinical symptoms and signs are also variable. Therefore, knowledge of the disease entities and the imaging findings of lesions involving the splenium is valuable in clinical practice. MR imaging is useful for the detection and differential diagnosis of splenial lesions of the CC. In this study, we classify the disease entities and describe imaging findings of lesions involving the splenium of the CC based on our experiences and a review of the literature.
[Mh] Termos MeSH primário: Corpo Caloso/diagnóstico por imagem
Imagem por Ressonância Magnética
[Mh] Termos MeSH secundário: Encefalopatias/diagnóstico por imagem
Confusão/diagnóstico por imagem
Confusão/patologia
Corpo Caloso/anatomia & histologia
Seres Humanos
Infarto/diagnóstico por imagem
Infarto/patologia
Lipoma/diagnóstico por imagem
Lipoma/patologia
Doenças Neurodegenerativas/diagnóstico por imagem
Doenças Neurodegenerativas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE
[do] DOI:10.3348/kjr.2017.18.4.710


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[PMID]:28655811
[Au] Autor:Gialdini G; Parikh NS; Chatterjee A; Lerario MP; Kamel H; Schneider DB; Navi BB; Murthy SB; Iadecola C; Merkler AE
[Ad] Endereço:From the Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute (G.G., N.S.P., A.C., H.K., B.B.N., S.B.M., C.I., A.E.M.), Department of Neurology (N.S.P., M.P.L., H.K., B.B.N., S.B.M., C.I., A.E.M.), and Department of Vascular and Endovascular Surgery (D.B.S.), W
[Ti] Título:Rates of Spinal Cord Infarction After Repair of Aortic Aneurysm or Dissection.
[So] Source:Stroke;48(8):2073-2077, 2017 Aug.
[Is] ISSN:1524-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: The rate of spinal cord infarction (SCI) after surgical or endovascular repair of an aortic aneurysm or dissection is unclear. METHODS: Using administrative claims data, we identified adult patients discharged from nonfederal acute care hospitals in California, New York, and Florida who underwent surgical or endovascular repair of an aortic aneurysm or dissection between 2005 and 2013. Patients with SCI diagnosed before the aortic repair were excluded. Our primary outcome was an SCI during the index hospitalization for aortic repair. Descriptive statistics were used to estimate crude rates of SCI. Analyses were stratified by whether the aneurysm or dissection had ruptured and by type of repair (surgical versus endovascular). RESULTS: We identified 91 212 patients who had repair of an aortic aneurysm or dissection. SCI occurred in 235 cases (0.26%; 95% confidence interval [CI], 0.22%-0.29%). In patients with ruptured aneurysm or dissection, the rate of SCI was 0.74% (95% CI, 0.60%-0.88%) compared with 0.16% (95% CI, 0.13%-0.19%) with unruptured aneurysm. In secondary analyses, rates of SCI were similar after endovascular repair (0.91%; 95% CI, 0.62%-1.19%) compared with surgical repair (0.68%; 95% CI, 0.53%-0.83%; =0.147) of ruptured aortic aneurysm or dissection; however, rates of SCI were higher after surgical repair (0.20%; 95% CI, 0.15%-0.25%) versus endovascular repair (0.11%; 95% CI, 0.08%-0.14%; <0.001) of unruptured aneurysm. CONCLUSIONS: SCI occurs in ≈1 in 130 patients undergoing aortic dissection or ruptured aortic aneurysm repair and in 1 in 600 patients undergoing unruptured aortic aneurysm repair.
[Mh] Termos MeSH primário: Aneurisma Dissecante/epidemiologia
Aneurisma Dissecante/cirurgia
Aneurisma Aórtico/epidemiologia
Aneurisma Aórtico/cirurgia
Complicações Pós-Operatórias/epidemiologia
Isquemia do Cordão Espinal/epidemiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
California/epidemiologia
Estudos de Coortes
Feminino
Florida/epidemiologia
Seres Humanos
Infarto/diagnóstico
Infarto/epidemiologia
Masculino
Meia-Idade
New York/epidemiologia
Complicações Pós-Operatórias/diagnóstico
Estudos Retrospectivos
Isquemia do Cordão Espinal/diagnóstico
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170924
[Lr] Data última revisão:
170924
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE
[do] DOI:10.1161/STROKEAHA.117.017071


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[PMID]:28573223
[Au] Autor:Wang Y; Wang W; Peng W; Liu W; Cai W; Xia Z; Zhang H; Xing AZ
[Ad] Endereço:Institute of Integrated Medicine, Xiangya Hospital, Central South University, Changsha 410008, P.R. China.
[Ti] Título:CARDIOPROTECTIVE ROLES OF THE CHINESE MEDICINAL FORMULA BAO-XIN-TANG ON ACUTE MYOCARDIAL INFARCTION IN RATS.
[So] Source:Afr J Tradit Complement Altern Med;14(2):65-74, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Bao-Xin-Tang (BXT) is a traditional Chinese medicinal formula used for the treatment of coronary heart disease and known to have favorable therapeutic benefits. The current study was designed to determine whether BXT has a cardioprotective role for acute myocardial infarction. The underlying mechanisms were also explored. MATERIALS AND METHODS: The Sprague-Dawley rat model of acute myocardial infarction was established by occluding the left anterior descending branch of the coronary artery. After a 3-h ischemic period, we determined the myocardial infarction size, inflammatory components, and antioxidant activities. RESULTS: The data showed that BXT could reduce the infarction size and lower the levels of C-reactive protein, interleukin-6, and myeloperoxidase, and increase the activities of superoxide dismutase and the anti-inflammatory cytokine, interleukin-10. These results indicate that administration of BXT, following acute myocardial infarction, could reduce infarct size. CONCLUSION: The effects of BXT may be related to its anti-inflammatory and anti-oxidative properties.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Antioxidantes/uso terapêutico
Cardiotônicos/uso terapêutico
Medicamentos de Ervas Chinesas/uso terapêutico
Infarto do Miocárdio/tratamento farmacológico
Fitoterapia
[Mh] Termos MeSH secundário: Doença Aguda
Animais
Anti-Inflamatórios/farmacologia
Antioxidantes/metabolismo
Antioxidantes/farmacologia
Proteína C-Reativa/metabolismo
Cardiotônicos/farmacologia
Vasos Coronários
Medicamentos de Ervas Chinesas/farmacologia
Infarto/prevenção & controle
Inflamação/sangue
Inflamação/prevenção & controle
Interleucina-10/metabolismo
Interleucina-6/metabolismo
Masculino
Infarto do Miocárdio/etiologia
Infarto do Miocárdio/metabolismo
Infarto do Miocárdio/patologia
Miocárdio/metabolismo
Miocárdio/patologia
Estresse Oxidativo/efeitos dos fármacos
Peroxidase/sangue
Ratos Sprague-Dawley
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Cardiotonic Agents); 0 (Drugs, Chinese Herbal); 0 (Interleukin-6); 130068-27-8 (Interleukin-10); 9007-41-4 (C-Reactive Protein); EC 1.11.1.7 (Peroxidase); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i2.8


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[PMID]:28501119
[Au] Autor:Hong J; Gilder E; Blenkiron C; Jiang Y; Evennett NJ; Petrov MS; Phillips ARJ; Windsor JA; Gillham M
[Ad] Endereço:School of Biological Sciences, Faculty of Science, University of Auckland, Auckland, New Zealand; Department of Surgery, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand. Electronic address: j.hong@auckland.ac.nz.
[Ti] Título:Nonocclusive mesenteric infarction after cardiac surgery: potential biomarkers.
[So] Source:J Surg Res;211:21-29, 2017 May 01.
[Is] ISSN:1095-8673
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Nonocclusive mesenteric ischemia can cause intestinal infarction but the diagnosis is challenging. This prospective study evaluated three plasma biomarkers of intestinal infarction after cardiac surgery. MATERIALS AND METHODS: Patients were recruited after cardiac surgery if they required laparotomy (with or without intestinal resection) for suspected nonocclusive mesenteric ischemia. Plasma levels of D-lactate, intestinal fatty acid-binding protein (i-FABP), and smooth muscle actin (SMA) before laparotomy were measured. RESULTS: Twenty patients were recruited (68 ± 9 y, EuroSCORE: 8.7 ± 2.8, mortality 70%). A positive laparotomy (n = 13) was associated with no change in D-lactate (P = 0.95), decreased i-FABP (P = 0.007), and increased SMA (P = 0.01). All patients with high SMA had a positive laparotomy. A subgroup analysis was undertaken in the eight patients who required multiple laparotomies. D-lactate increased between the two laparotomies in nonsurvivors (n = 4). Plasma i-FABP (P = 0.008) and SMA (P = 0.036) significantly decreased after the bowel resection, regardless of survival outcome. CONCLUSIONS: None of the biomarkers were accurate enough to reliably diagnose intestinal infarction. However, all patients with high values of SMA developed intestinal infarction, thus warranting further investigation. An increasing D-lactate after intestinal resection suggests impending death.
[Mh] Termos MeSH primário: Actinas/sangue
Procedimentos Cirúrgicos Cardíacos
Proteínas de Ligação a Ácido Graxo/sangue
Infarto/diagnóstico
Ácido Láctico/sangue
Isquemia Mesentérica/diagnóstico
Complicações Pós-Operatórias/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Biomarcadores/sangue
Feminino
Seres Humanos
Infarto/sangue
Infarto/etiologia
Infarto/cirurgia
Intestinos/irrigação sanguínea
Laparotomia
Masculino
Isquemia Mesentérica/sangue
Isquemia Mesentérica/etiologia
Isquemia Mesentérica/cirurgia
Meia-Idade
Projetos Piloto
Complicações Pós-Operatórias/sangue
Complicações Pós-Operatórias/cirurgia
Estudos Prospectivos
Curva ROC
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Actins); 0 (Biomarkers); 0 (Fatty Acid-Binding Proteins); 33X04XA5AT (Lactic Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170515
[St] Status:MEDLINE



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