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[PMID]:28404534
[Au] Autor:Parvez R; Sugunan AP; Vijayachari P; Burma SP; Mandal A; Saha MK; Shah WA
[Ad] Endereço:Regional Medical Research Centre (ICMR), Post Bag No. 13, Dollygunj, Port Blair, Andaman and Nicobar Islands 744101, India. Electronic address: drrehnumaparvez@rediffmail.com.
[Ti] Título:Prevalence of female genital tuberculosis, its risk factors and associated clinical features among the women of Andaman Islands, India: a community-based study.
[So] Source:Public Health;148:56-62, 2017 Jul.
[Is] ISSN:1476-5616
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: There is scarcity of information on the prevalence of female genital tuberculosis (FGTB) in the community. The present study was carried out to estimate the prevalence of FGTB, its risk factors and associated clinical features. STUDY DESIGN: Community-based cross-sectional survey. METHODS: This study was carried during October 2011 and May 2014 in the Andaman Islands. A total of 13,300 women aged 20-59 years were primarily screened using a structured questionnaire. About 721 (5.4%) were found initially eligible for screening for genital tuberculosis by clinical examination and specimen collection for laboratory tests but only 460 (63.8%) expressed their willingness. Endometrial specimens were collected from 405 (88%) subjects. The association of the potential risk factors with genital tuberculosis was tested by Chi-squared test. A similar analysis was performed to identify clinical features associated with genital tuberculosis. RESULTS: The estimated prevalence of FGTB was 45.1 cases per 100,000 women (95% confidence interval [CI]: 16.6-98.1). Infertility and oligomenorrhoea were identified as clinical features associated with FGTB. Past history of tuberculosis and history of close contact with tuberculosis cases were identified as risk factors. CONCLUSIONS: This study shows the prevalence of FGTB among the female population of the Andaman Islands. Though the estimated prevalence was close to the expected prevalence, but as only 63.8% of the eligible women could be adequately screened, a much higher prevalence of FGTB could not be ruled out. Infertility, oligomenorrhoea, past history of tuberculosis and contact with tuberculosis case were identified as factors associated with genital tuberculosis.
[Mh] Termos MeSH primário: Tuberculose dos Genitais Femininos/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Estudos Transversais
Feminino
Seres Humanos
Índia/epidemiologia
Infertilidade Feminina/epidemiologia
Meia-Idade
Oligomenorreia/epidemiologia
Prevalência
Fatores de Risco
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE


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[PMID]:28323926
[Au] Autor:Karjula S; Morin-Papunen L; Auvinen J; Ruokonen A; Puukka K; Franks S; Järvelin MR; Tapanainen JS; Jokelainen J; Miettunen J; Piltonen TT
[Ad] Endereço:Department of Obstetrics and Gynecology, University Hospital of Oulu, University of Oulu, FI-90014 Oulu, Finland.
[Ti] Título:Psychological Distress Is More Prevalent in Fertile Age and Premenopausal Women With PCOS Symptoms: 15-Year Follow-Up.
[So] Source:J Clin Endocrinol Metab;102(6):1861-1869, 2017 Jun 01.
[Is] ISSN:1945-7197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Context: Polycystic ovary syndrome (PCOS) is associated with increased psychological distress, obesity and hyperandrogenism being suggested as key promoters. Objectives: To investigate the prevalence of anxiety/depression and their coexistence in women with PCOS/PCOS-related symptoms at ages 31 and 46. The roles of obesity, hyperandrogenism, and awareness of PCOS on psychological distress were also assessed. Design: Population-based follow-up. Setting: Northern Finland Birth Cohort 1966 with 15-year follow-up. Participants: At age 31, a questionnaire-based screening for oligoamenorrhea (OA) and hirsutism (H): 2188 asymptomatic (controls), 331 OA, 323 H, and 125 OA plus H (PCOS). Follow-up at age 46: 1576 controls, 239 OA, 231 H, and 85 PCOS. Interventions: Questionnaire-based screening for anxiety and depression symptoms (Hopkins Symptom Checklist-25) and previously diagnosed/treated depression at ages 31 and 46. Body mass index (BMI), serum testosterone/free androgen index, and awareness of polycystic ovaries/PCOS on psychological distress were also assessed. Main Outcomes: Population-based prevalence of anxiety and/or depression in women with PCOS/PCOS-related symptoms at ages 31 and 46. Results: Anxiety and/or depression symptoms, their coexistence, and rate of depression were increased at ages 31 and 46 in women with PCOS or isolated H compared with controls. High BMI or hyperandrogenism did not associate with increased anxiety or depression symptoms. The awareness of PCOS was associated with increased anxiety. Conclusions: Women with PCOS or isolated H present more often with anxiety and/or depression symptoms and their coexistence compared with controls. High BMI or hyperandrogenism did not provoke psychological distress in PCOS. The awareness of PCOS increased anxiety but did not associate with severe anxiety or depression.
[Mh] Termos MeSH primário: Ansiedade/epidemiologia
Depressão/epidemiologia
Hirsutismo/epidemiologia
Hiperandrogenismo/epidemiologia
Obesidade/epidemiologia
Oligomenorreia/epidemiologia
Síndrome do Ovário Policístico/epidemiologia
Estresse Psicológico/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Ansiedade/psicologia
Depressão/psicologia
Feminino
Finlândia/epidemiologia
Hirsutismo/psicologia
Seres Humanos
Hiperandrogenismo/psicologia
Meia-Idade
Obesidade/psicologia
Oligomenorreia/psicologia
Síndrome do Ovário Policístico/psicologia
Pré-Menopausa
Prevalência
Estresse Psicológico/psicologia
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1210/jc.2016-3863


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[PMID]:28297591
[Au] Autor:Baskaran C; Cunningham B; Plessow F; Singhal V; Woolley R; Ackerman KE; Slattery M; Lee H; Lawson EA; Eddy K; Misra M
[Ad] Endereço:Pediatric Endocrinology, Massachusetts General Hospital for Children, 101 Merrimac, Ste 615, Boston, MA 02114. cbaskaran@mgh.harvard.edu.
[Ti] Título:Estrogen Replacement Improves Verbal Memory and Executive Control in Oligomenorrheic/Amenorrheic Athletes in a Randomized Controlled Trial.
[So] Source:J Clin Psychiatry;78(5):e490-e497, 2017 May.
[Is] ISSN:1555-2101
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Both estrogen and exercise may have cognition enhancing benefits; however, young oligomenorrheic/amenorrheic athletes (OA) with estrogen deficiency have not been evaluated for cognitive deficits. Our objective was to determine whether 6 months of estrogen replacement will impact cognitive domains in OA. We hypothesized that estrogen replacement would improve verbal memory and executive control in OA. METHODS: We performed cognitive assessments at baseline and after 6 months in 48 OA (14-25 years) randomized to estrogen (EST+) (oral 30 µg ethinyl estradiol [n = 16] or transdermal 100 µg 17-ß-estradiol patch [n = 13]) or no estrogen (EST-) (n = 19) in an ongoing clinical trial. Neurocognitive testing included California Verbal Learning Test-Second Edition (CVLT-II) (for verbal memory) and Delis-Kaplan Executive Function System Color-Word Interference Test (D-KEFS-CWIT) (executive control). RESULTS: On average, subjects (mean ± SEM age: 19.9 ± 3.1 years, body mass index: 20.6 ± 2.3 kg/m²) participated in 10.3 ± 5.9 hours per week of weight-bearing activities of their lower limbs. The EST+ group performed better for CVLT-II verbal memory scores for immediate recall over 6 months of therapy compared to EST- (P < .05) even after controlling for baseline scores and age. Changes in D-KEFS-CWIT scores over 6 months did not differ between the groups. However, the EST+ group had greater improvements in inhibition-switching completion time over 6 months compared with the EST- group after controlling for baseline scores and age (P = .01). CONCLUSIONS: OA show improvements in verbal memory and executive control following 6 months of estrogen replacement. These findings in athletes, who are in their prime of neurocognitive development, underscore the need for future studies exploring cognition in OA. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00946192.
[Mh] Termos MeSH primário: Amenorreia/tratamento farmacológico
Amenorreia/psicologia
Atletas
Terapia de Reposição de Estrogênios
Função Executiva/efeitos dos fármacos
Rememoração Mental/efeitos dos fármacos
Oligomenorreia/tratamento farmacológico
Oligomenorreia/psicologia
Aprendizagem Verbal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Cutânea
Administração Oral
Adolescente
Feminino
Seguimentos
Seres Humanos
Testes Neuropsicológicos
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170616
[Lr] Data última revisão:
170616
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE


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[PMID]:27908842
[Au] Autor:Özler S; Öztas E; Tokmak A; Ergin M; Kuru Pekcan M; Gümüs Güler B; Yakut HI; Yilmaz N
[Ad] Endereço:Zekai Tahir Burak Women's Health Training and Research Hospital, Clinic of Perinatology, Ankara, Turkey Phone: +90 312 306 50 00 E-mail: sibel2ozler@gmail.com.
[Ti] Título:Role of Versican and ADAMTS-1 in Polycystic Ovary Syndrome.
[So] Source:J Clin Res Pediatr Endocrinol;9(1):24-30, 2017 Mar 01.
[Is] ISSN:1308-5735
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: ADAMTS-1 is a matrix metalloproteinase which cleaves versican in the cumulus oocyte complex under the effect of luteinizing hormone surge in the periovulatory period. Altered levels may have a role in the pathogenesis of polycystic ovary syndrome (PCOS). We aimed to determine the serum versican and ADAMTS-1 (a disintegrin and metalloproteinase with thrombospondin motif-1) levels in PCOS patients and compare the results with healthy controls. METHODS: Thirty-eight patients with PCOS and forty healthy controls aged between 15 and 22 years were included in the study. They were sampled according to their basal hormone, serum versican, and ADAMTS-1 levels. Serum versican and ADAMTS-1 levels were measured by enzyme-linked immunosorbent assay. A multivariate logistic regression model was used to identify the independent risk factors of PCOS. RESULTS: Serum versican levels were significantly decreased in the PCOS group when compared with the controls. The best versican cut-off value for PCOS was calculated to be 33.65 with 76.74% sensitivity and 52.94% specificity. Serum versican levels, homeostasis model assessment of insulin resistance index, a Ferriman-Gallwey score higher than 8, and oligomenorrhea were the strongest predictors of PCOS. Serum versican levels were significantly decreased in PCOS patients. Besides, serum ADAMTS-1 and versican levels were significantly and positively correlated with each other. CONCLUSION: Serum versican levels were significantly decreased in patients with PCOS. This suggests a possible role of versican in ovulatory dysfunction and in the pathogenesis of PCOS.
[Mh] Termos MeSH primário: Proteína ADAMTS1/sangue
Síndrome do Ovário Policístico/sangue
Medição de Risco/métodos
Versicanas/sangue
[Mh] Termos MeSH secundário: Adolescente
Índice de Massa Corporal
Ensaio de Imunoadsorção Enzimática
Feminino
Seres Humanos
Resistência à Insulina
Modelos Logísticos
Análise Multivariada
Oligomenorreia/sangue
Oligomenorreia/diagnóstico
Síndrome do Ovário Policístico/diagnóstico
Curva ROC
Valores de Referência
Medição de Risco/estatística & dados numéricos
Fatores de Risco
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (VCAN protein, human); 126968-45-4 (Versicans); EC 3.4.24.- (ADAMTS1 Protein); EC 3.4.24.- (ADAMTS1 protein, human)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE
[do] DOI:10.4274/jcrpe.3414


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[PMID]:27827529
[Au] Autor:Martin LA; Porter AG; Pelligrini VA; Schnatz PF; Jiang X; Kleinstreuer N; Hall JE; Verbiest S; Olmstead J; Fair R; Falorni A; Persani L; Rajkovic A; Mehta K; Nelson LM; Rachel's Well Primary Ovarian Insufficiency Community of Practice Group
[Ad] Endereço:ConoverSystems, Ashburn, VA, USA.
[Ti] Título:A design thinking approach to primary ovarian insufficiency.
[So] Source:Panminerva Med;59(1):15-32, 2017 Mar.
[Is] ISSN:1827-1898
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Most clinicians are not prepared to provide integrated personal care to address all the clinical needs of women with primary ovarian insufficiency. Design thinking is an engineering methodology used to develop and evaluate novel concepts for systems operation. Here we articulate the need for a seamlessly integrated mobile health system to support genomic research as well as patient care. We also review the pathophysiology and management of primary ovarian insufficiency. Molecular understanding regarding the pathogenesis is essential to developing strategies for prevention, earlier diagnosis, and appropriate management of the disorder. The syndrome is a chronic disorder characterized by oligo/amenorrhea and hypergonadotropic hypogonadism before age 40 years. There may be significant morbidity due to: 1) depression and anxiety related to the loss of reproductive hormones and infertility; 2) associated autoimmune adrenal insufficiency or hypothyroidism; and 3) reduced bone mineral density and increased risk of cardiovascular disease related to estrogen deficiency. Approximately 5% to 10% of women with primary ovarian insufficiency conceive and have a child. Women who develop primary ovarian insufficiency related to a premutation in FMR1 are at risk of having a child with fragile X syndrome, the most common cause of inherited intellectual disability. In most cases of spontaneous primary ovarian insufficiency no environmental exposure or genetic mechanism can be identified. As a rare disease, the diagnosis of primary ovarian insufficiency presents special challenges. Connecting patients and community health providers in real time with investigators who have the requisite knowledge and expertise would help solve this dilemma.
[Mh] Termos MeSH primário: Ovário/fisiopatologia
Insuficiência Ovariana Primária/diagnóstico
Insuficiência Ovariana Primária/terapia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Animais
Doença Crônica
Feminino
Fertilidade
Ginecologia/métodos
Ginecologia/tendências
Seres Humanos
Camundongos
Meia-Idade
Oligomenorreia/fisiopatologia
Gravidez
Insuficiência Ovariana Primária/psicologia
Teoria de Sistemas
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161110
[St] Status:MEDLINE
[do] DOI:10.23736/S0031-0808.16.03259-6


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[PMID]:27808591
[Au] Autor:Kjær MM; Madsbad S; Hougaard DM; Cohen AS; Nilas L
[Ad] Endereço:a Department of Obstetrics and Gynecology , Hvidovre University Hospital , Denmark.
[Ti] Título:The impact of gastric bypass surgery on sex hormones and menstrual cycles in premenopausal women.
[So] Source:Gynecol Endocrinol;33(2):160-163, 2017 Feb.
[Is] ISSN:1473-0766
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Obesity has adverse effects on ovulation, menstrual cyclicity and oocyte development leading to clinical symptoms such as infertility and menstrual disorders. The Roux-en-Y gastric bypass (RYGB) leads to weight loss, improved insulin sensitivity and may improve ovarian function. In 31 premenopausal women, 18 eu- and 13 oligo-/amenorrhoic, we followed the changes in follicular phase sex hormones 3, 6 and 12 month after RYGB. The average weight loss during the first postoperative year was 39.6 kg. The insulin sensitivity and serum insulin improved markedly especially within the first three postoperative months. SHBG increased progressively and was doubled after 12 months. In contrast, total and free androgens and DHEA declined about 50% during the first three postoperative months and remained fairly constant hereafter. One year after surgery, 85% (11/13) of the women with oligo-/amenorrhea gained regular menstrual cycles. Our results indicate that some of the endocrine changes related to regulation of ovarian function occur very early after bariatric surgery.
[Mh] Termos MeSH primário: Amenorreia/sangue
Fase Folicular/sangue
Derivação Gástrica
Hormônios Esteroides Gonadais/sangue
Obesidade
Oligomenorreia/sangue
Avaliação de Resultados (Cuidados de Saúde)
Pré-Menopausa/sangue
Globulina de Ligação a Hormônio Sexual/metabolismo
[Mh] Termos MeSH secundário: Adulto
Amenorreia/etiologia
Feminino
Seguimentos
Seres Humanos
Meia-Idade
Obesidade/sangue
Obesidade/complicações
Obesidade/cirurgia
Oligomenorreia/etiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gonadal Steroid Hormones); 0 (Sex Hormone-Binding Globulin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161104
[St] Status:MEDLINE
[do] DOI:10.1080/09513590.2016.1236243


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[PMID]:27553698
[Au] Autor:Singha A; Biswas D; Patil M
[Ad] Endereço:Dept. of Endocrinology & Metabolism, Institute of Post Graduate Medical Education & Research/SSKM Hospital, Kolkata 700020, West Bengal, India. Electronic address: drarijits@gmail.com.
[Ti] Título:A young woman with oligomenorrohea and dysphagia.
[So] Source:Eur J Intern Med;37:e7-e8, 2017 Jan.
[Is] ISSN:1879-0828
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A 35-year-old house wife attended our clinic with oligomenorrhea for the last three months. She also complained of diffuse body ache, joint pain and decreased bowel movements. Very often she experienced choking sensation in the throat and had difficulty in swallowing solid food. On examination, goitre was absent but a globular pink colour mass was detected at the base of the tongue.
[Mh] Termos MeSH primário: Transtornos de Deglutição/etiologia
Tireoide Lingual/complicações
Oligomenorreia/etiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Terapia de Reposição Hormonal
Seres Humanos
Tireoide Lingual/diagnóstico por imagem
Tireoide Lingual/tratamento farmacológico
Tomografia por Emissão de Pósitrons
Tiroxina/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
Q51BO43MG4 (Thyroxine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160825
[St] Status:MEDLINE


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[PMID]:27318183
[Au] Autor:Comim FV; Marchesan LQ; Copes RM; de Vieira AR; Moresco RN; Compston JE; Premaor MO
[Ad] Endereço:Department of Clinical Medicine, Health Science Center, Federal University of Santa Maria, Santa Maria, Brazil. Electronic address: fabio.comim@ufsm.br.
[Ti] Título:Increased risk of humerus and lower leg fractures in postmenopausal women with self-reported premenopausal hirsutism and/or oligomenorrhea.
[So] Source:Eur J Obstet Gynecol Reprod Biol;203:162-6, 2016 Aug.
[Is] ISSN:1872-7654
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this study was to investigate the prevalence of fracture in women aged >55 years with self-reported premenopausal hirsutism and/or oligomenorrhea. STUDY DESIGN: A cross-sectional study including 1057 post-menopausal women aged >55 years who were treated in a primary care facility in Santa Maria, South Brazil, from March 2013 through August 2013. Data were collected using a standardized questionnaire for characteristics including fracture history, medication use, and reproductive history (oligomenorrhea, hirsutism, miscarriage, the diagnosis or treatment of hypothyroidism, hyperprolactinemia, or infertility). RESULTS: A non-significant trend towards an increased prevalence of all fragility fractures was observed in women with premenopausal hirsutism and/or oligomenorrhea when compared to those without (20.4% vs. 15.7%). After correction for age, falls, and comorbidities, fracture prevalence was significantly higher in the lower leg (OR 3.1 [CI 1.1-8.6]; P=0.029), and humerus (OR 2.6 [CI 1.2-5.4]; P=0.015) in the women with hirsutism and/or oligomenorrhea. CONCLUSION: This is a hypothesis-generating study which evaluated the association between hirsutism and/or oligomenorrhea and fractures in postmenopausal women. Our results suggest that premenopausal hirsutism and/or oligomenorrhea may be associated with an increased risk of fracture postmenopause, particularly in the humerus and lower leg.
[Mh] Termos MeSH primário: Hirsutismo/fisiopatologia
Fraturas do Úmero/etiologia
Oligomenorreia/fisiopatologia
Osteoporose Pós-Menopausa/fisiopatologia
Fraturas por Osteoporose/etiologia
Fraturas da Tíbia/etiologia
[Mh] Termos MeSH secundário: Idoso
Brasil/epidemiologia
Comorbidade
Estudos Transversais
Feminino
Fíbula
Inquéritos Epidemiológicos
Hirsutismo/epidemiologia
Seres Humanos
Fraturas do Úmero/epidemiologia
Meia-Idade
Oligomenorreia/epidemiologia
Osteoporose Pós-Menopausa/epidemiologia
Fraturas por Osteoporose/epidemiologia
Pré-Menopausa
Prevalência
Atenção Primária à Saúde
Risco
Autorrelato
Fraturas da Tíbia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170413
[Lr] Data última revisão:
170413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160619
[St] Status:MEDLINE


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[PMID]:27173790
[Au] Autor:Savas-Erdeve S; Keskin M; Sagsak E; Cenesiz F; Cetinkaya S; Aycan Z
[Ad] Endereço:Department of Pediatric Endocrinology, Dr. Sami Ulus Obstetrics and Gynecology, Children's Health and Disease Training and Research Hospital, Ankara, Turkey.
[Ti] Título:Do the Anti-Müllerian Hormone Levels of Adolescents with Polycystic Ovary Syndrome, Those Who Are at Risk for Developing Polycystic Ovary Syndrome, and Those Who Exhibit Isolated Oligomenorrhea Differ from Those of Adolescents with Normal Menstrual Cycles?
[So] Source:Horm Res Paediatr;85(6):406-11, 2016.
[Is] ISSN:1663-2826
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIMS: We aimed to investigate whether the anti-Müllerian hormone (AMH) levels in adolescents with polycystic ovary syndrome (PCOS), PCOS risk, and isolated oligomenorrhea (OM) were different than in adolescents with a normal/regular menstrual cycle (NMC). METHODS: The diagnosis of PCOS was based on the 2012 Amsterdam [European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine (ESHRE/ASRM)] criteria. The PCOS group consisted of cases meeting 3 diagnostic criteria (n = 21), and the PCOS risk group was the 'at risk' group meeting 2 diagnostic criteria (n = 20). Cases with isolated OM that did not satisfy other PCOS diagnostic criteria made up the OM group (n = 21). Thirty adolescent girls with NMCs (21-45 days) were recruited in this study. RESULTS: The AMH levels in the PCOS group were similar to those in the PCOS risk group but significantly higher than those in the OM and NMC groups. The AMH levels in the PCOS risk group were similar to those in the OM group and significantly higher than those in the NMC group. They were also significantly higher in the OM group compared to the NMC group. The specificity for PCOS and PCOS risk with a cutoff value of 7.25 ng/ml for AMH was 72.5% and the sensitivity was 58%. CONCLUSION: An AMH cutoff value of 7.25 ng/ml can be used for the diagnosis of PCOS in the adolescent period.
[Mh] Termos MeSH primário: Hormônio Antimülleriano/sangue
Ciclo Menstrual/sangue
Oligomenorreia
Síndrome do Ovário Policístico
[Mh] Termos MeSH secundário: Adolescente
Feminino
Seres Humanos
Oligomenorreia/sangue
Oligomenorreia/diagnóstico
Síndrome do Ovário Policístico/sangue
Síndrome do Ovário Policístico/diagnóstico
Valor Preditivo dos Testes
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
80497-65-0 (Anti-Mullerian Hormone)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170406
[Lr] Data última revisão:
170406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160514
[St] Status:MEDLINE
[do] DOI:10.1159/000446111


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[PMID]:27089404
[Au] Autor:Nezi M; Christopoulos P; Paltoglou G; Gryparis A; Bakoulas V; Deligeoroglou E; Creatsas G; Mastorakos G
[Ti] Título:Focus on BMI and subclinical hypothyroidism in adolescent girls first examined for amenorrhea or oligomenorrhea. The emerging role of polycystic ovary syndrome.
[So] Source:J Pediatr Endocrinol Metab;29(6):693-702, 2016 Jun 01.
[Is] ISSN:2191-0251
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Primary amenorrhea, oligomenorrhea and secondary amenorrhea are diagnosed commonly during adolescence. Weight aberrations are associated with menstrual disorders. Autoimmune thyroiditis is frequent during adolescence. In this study, the commonest clinical and hormonal characteristics of amenorrhea or oligomenorrhea during adolescence were investigated. METHODS: In this cross-sectional study, one hundred and thirty-eight consecutive young patients presenting with amenorrhea or oligomenorrhea referred to an adolescent endocrinology and gynecology university clinic were studied. Clinical examination and an abdominal ultrasound were performed. Testosterone, free-testosterone, estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), dehydroepiandrosterone sulfate (DHEA-S), 17-OH progesterone, sex hormone binding globulin (SHBG), Δ4-androstenedione (Δ4A), free androgen index (FAI), insulin, glucose, thyroid stimulating hormone (TSH), total thyroxine (T4) (TT4), free T4 (FT4), total triiodothyronine (T3) (TT3) and free T3 (FT3). Concentrations were measured in blood samples. RESULTS: Patients with primary and secondary amenorrhea presented more often with body mass index (BMI) <18.5 and BMI >25 kg/m2, respectively. BMI values correlated positively with insulin (r=0.742) and glucose (r=0.552) concentrations and negatively with glucose/insulin ratio values (r=-0.54); BMI values and insulin concentrations correlated positively with FAI values (r=0.629 and r=0.399, respectively). In all patients, BMI values correlated positively and negatively with free testosterone (r=0.249) and SHBG (r=-0.24) concentrations, respectively. In patients with secondary amenorrhea insulin concentrations correlated negatively with SHBG concentrations (r=-0.75). In patients with oligomenorrhea BMI values correlated positively with insulin (r=0.490) and TSH (r=0.325) concentrations, and negatively with SHBG (r=-0.33) concentrations. Seventy-two percent, 21% and 7% of patients presented with TSH concentrations <2.5 µIU/mL, between 2.5 µIU/mL, 4.5 µIU/mL and >4.5 µIU/mL (subclinical hypothyroidism), respectively. Following the definition of polycystic ovary syndrome (PCOS) according to either the National Institutes of Health (NIH) criteria or those proposed in the literature by Carmina and his team, patients presented mainly with oligomenorrhea or secondary amenorrhea. There was good agreement between patients with amenorrhea or oligomenorrhea fulfilling both of the PCOS definition criteria employed. CONCLUSIONS: Among adolescent patients presenting with amenorrhea or oligomenorrhea for the first time those with low and high BMI present more often with primary and secondary amenorrhea, respectively. Obesity is involved in the development of hyperandrogenemia and hyperinsulinemia, particularly in PCOS patients. In these patients, subclinical hypothyroidism may be concealed and it should be investigated. These patients should be treated for abnormally increased or decreased BMI and be investigated for autoimmune thyroiditis.
[Mh] Termos MeSH primário: Amenorreia/etiologia
Índice de Massa Corporal
Hipotireoidismo/complicações
Oligomenorreia/etiologia
Síndrome do Ovário Policístico/complicações
[Mh] Termos MeSH secundário: Adolescente
Adulto
Amenorreia/sangue
Estudos Transversais
Feminino
Seres Humanos
Insulina/sangue
Oligomenorreia/sangue
Globulina de Ligação a Hormônio Sexual/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insulin); 0 (Sex Hormone-Binding Globulin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160419
[St] Status:MEDLINE



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