[PMID]: | 28056319 |
[Au] Autor: | Xu B; Yang CZ; Wu SB; Zhang D; Wang LN; Xiao L; Chen Y; Wang CR; Tong A; Zhou XF; Li XH; Guan XH |
[Ad] Endereço: | Department of Endocrinology, Air Force General Hospital of PLA, Beijing 100142, China. |
[Ti] Título: | [Risk factors for lower extremity amputation in patients with diabetic foot]. |
[So] Source: | Zhonghua Nei Ke Za Zhi;56(1):24-28, 2017 Jan 01. |
[Is] ISSN: | 0578-1426 |
[Cp] País de publicação: | China |
[La] Idioma: | chi |
[Ab] Resumo: | To explore the risk factors for lower extremity amputation in patients with diabetic foot. The clinical data of 1 771 patients with diabetic foot at the Air Force General Hospital of PLA from November 2001 to April 2015 were retrospectively analyzed. The patients were divided into the non-amputation and amputation groups. Within the amputation group, subjects were further divided into the minor and major amputation subgroups. Binary logistic regression analyses were used to assess the association between risk factors and lower extremity amputation. Among 1 771 patients with diabetic foot, 323 of them (18.24%) were in the amputation group (major amputation: 41; minor amputation: 282) and 1 448 (81.76%) in the non-amputation group. Compared with non-amputation patients, those in the amputation group had a longer hospital stay and higher estimated glomerular filtration rate(eGFR)levels. Fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), C-reaction protein (CRP), ESR, ferritin, fibrinogen and WBC levels of the amputation group were higher, while hemoglobin albumin, transferrin, TC, TG, HDL-C and LDL-C were lower than those of the non-amputation group (all <0.05). The proportion of hypertension(52.48% vs 59.98%), peripheral vascular disease (PAD)(68.11% vs 25.04%), and coronary heart disease(21.33% vs 28.71%)were different between the amputation and non-amputation groups (all <0.05). Multivariable logistic regression analyses showed that Wagner's grade, PAD and CRP were the independent risk factors associated with lower extremity amputation in hospitalized patients with diabetic foot. Wagner's grade, ischemia of lower limbs and infection are closely associated with amputation of diabetic foot patients. |
[Mh] Termos MeSH primário: |
Amputação/estatística & dados numéricos Diabetes Mellitus Tipo 1/complicações Diabetes Mellitus Tipo 2/complicações Pé Diabético/cirurgia Pé/cirurgia
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[Mh] Termos MeSH secundário: |
Idoso China/epidemiologia Doença da Artéria Coronariana/complicações Diabetes Mellitus Tipo 2/sangue Pé Diabético/sangue Pé Diabético/epidemiologia Feminino Gangrena/complicações Hemoglobina A Glicada/metabolismo Seres Humanos Incidência Masculino Meia-Idade Receptor do Fator de Crescimento Epidérmico/sangue Estudos Retrospectivos Medição de Risco Fatores de Risco
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Glycated Hemoglobin A); EC 2.7.10.1 (EGFR protein, human); EC 2.7.10.1 (Receptor, Epidermal Growth Factor) |
[Em] Mês de entrada: | 1706 |
[Cu] Atualização por classe: | 171116 |
[Lr] Data última revisão:
| 171116 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 170106 |
[St] Status: | MEDLINE |
[do] DOI: | 10.3760/cma.j.issn.0578-1426.2017.01.007 |
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